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<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3X9</accession>
    <name>A0A370P3X9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_114110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3X9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="60230" checksum="194A13097186384C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P458</accession>
    <name>A0A370P458_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_280318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P458"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="306"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="629" mass="71780" checksum="5A8FEFD8B6C995B4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P497</accession>
    <name>A0A370P497_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_112943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P497"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="133" mass="15364" checksum="2C8887F323FAFC88" modified="2018-11-07" version="1">MFYNALIRTHHITSRKKVSALKRAADIHNCFVLLRSGGCPGIMYVEAKDQGAVESWVTVVRKLRYKDFQLATRPGPLHDENQTELRDQQQLPQTKMRDIRAGVSEVETVKEFGSLMEQRGVWKWWRKGMGYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4G2</accession>
    <name>A0A370P4G2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">M752DRAFT_298833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4G2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="229" mass="25709" checksum="BF079B578FB9BA3C" modified="2018-11-07" version="1">MDDSLDIDESLIPVRDLKPASQSTISFDGMLSNPLLLQEDLKEGCGGQLWPAGMVLSKYLLRQHHSSFLGKTIVELGAGGGLVGLALARGCHPEMPRIYITDQAPMLPLMKTNIKLNNLSSTVEATVLNWGDSLPDCIPKHPAIILAADCVYFEPAFPLLISTLNDLLGPESVCYFCFKRRRRADLRFMKHARKMFDVDEIRDDPEAETYRRENIFLYQIRLKSSKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5C0</accession>
    <name>A0A370P5C0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_322062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5C0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="46807" checksum="8FF3E6FB754AF305" modified="2018-11-07" version="1">MFTNSSHANGASQKPVDGLIRQVAQAADSFHNSHDEADRLAALQAAQKLVEAFQKPQDAVYNLAYSPTHVMCVRIAMDLGIFSTLSERNGPVTLEDLAATKGADLVLTERVLRILAGIGYVAEHDVRVYTPTTMTRQMTDRLSGAVVRFIFDIGMPTLAKVPEFLRMTNFQNPSGAVKGALQYAEKTEMSLWDWVPTKPGFLDACNTFMEADRGSRPSWLEWFPVKERIIDGFHQGESNVLLVDVAGGRGHDLVAFESKFSEVQGRLILEDLPHVVAEATQHPKIEHVSFDLFQAQPIQGARTYYMKFILHDWSDEESRQILSHLAAAMKMGYSKLIIEEFVLADKDCAMLPAMWDWEMLIFCNSMERTASQWTKVLDSAGFRVVKFWAPPGDGQSIIEAELKEPAEPESSRLALSSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5H5</accession>
    <name>A0A370P5H5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_298533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5H5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="610" mass="67036" checksum="1D4A14D81780B114" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5P0</accession>
    <name>A0A370P5P0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_321998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5P0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="36815" checksum="8CA30B4276AA17A3" modified="2018-11-07" version="1">MKPIFILNLRDSITIITTTTTKVPVKSRHASGASLGGPQENPTRHGVVLWLSLPADHLGALYRVTEERPSNMPLRSIRSSACRNKAVSRGAYAFEKVGKGWTAERSNPDTRPALTRPAARISTASVWRSNPGKFDSFTITSEVLDPLSEPCSGPTQSTPQLVLYLMEGCYELAGPGTTRDTHDDLPVGRKGVNNLGTSRLGFHLSGNIEHLRSLFSGGSVSSIPLVIRYPFYFLLCTKDAVDQLRREGQARPTPPGTVAGNQEPLPRNPGPYTSKRRQPSQARKWKRKSLLISAGAHRPDNFGTLAVCIDPGRRRPMSTITVLVPLGIDLDPRGRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6G0</accession>
    <name>A0A370P6G0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_224245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6G0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="601" mass="68160" checksum="F5CBFB4B953088ED" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6G7</accession>
    <name>A0A370P6G7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_330484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6G7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="41279" checksum="8C8F2047031B9830" modified="2018-11-07" version="1">MADNQPSPDYSRPQFPAHNEPRVWVITAGDSPIGISVTRQILMHGDYALVGLAHSSLDRDECRRDMFDAFLAEIESNEGWGKRFKALPLDIRMVGECQAIVAQAVASFGRVDVLLCCTSQALIGTVEELSASQQTLNLVRDQFESNYFGPLNIIKAALPHMRRQKAGHITILSGITAHIGTPGLGMYCAAGWALEGFCDSLAYEIAPFNIKLTIFQCSIEIGILTNLVTSVPPIGPVYSSAANHAPLFRGIMNRLVSRLSSNTQSSAGSSNGSNQGNSIEDGPFSASEVISTYPPLSSAHMEVLVSETVYAITAIAGHENPPSRHIVGQEGVASVKEKLKTVSEELEDFIQASFAVDYAADEAGRSSKEEGMIMGMGTGHEGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Z2</accession>
    <name>A0A370P6Z2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_204972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Z2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="55" mass="5766" checksum="98E3390C31390640" modified="2018-11-07" version="1" fragment="single">LLIQGVDVNCADGWGRTALHYAVRAAHVDIVTQLLAAGAEIGARDHHGQSPLHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P728</accession>
    <name>A0A370P728_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_308629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P728"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016563337" evidence="1">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="27"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="528" mass="57355" checksum="0A9B146D0CFB8285" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P770</accession>
    <name>A0A370P770_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M752DRAFT_258386</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Fatty acid synthase is composed of alpha and beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 17">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 17 21" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="23">
        <location>
            <begin position="1016"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1628"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1632"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="18">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="1676"/>
            <end position="1678"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1676"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1678"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1702"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1712"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="1721"/>
            <end position="1737"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="1745"/>
            <end position="1747"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="1774"/>
            <end position="1776"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1775"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1776"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="21">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RDK37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1795" mass="194384" checksum="3FF89AEE5EDCD379" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P778</accession>
    <name>A0A370P778_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_258428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
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    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
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    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
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        <property type="protein sequence ID" value="RDK37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370P778"/>
    <dbReference type="SMR" id="A0A370P778"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
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    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
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    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
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    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="865" mass="93629" checksum="48C414A2A454F303" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N1</accession>
    <name>A0A370P7N1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_339142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7N1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="179"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="299" mass="32515" checksum="F92BD6C7E36AEC90" modified="2018-11-07" version="1">MGPISSLLVSPAELHHLLKAASTAFRIVPVAAGNHSTLPSFESRHVPNSVFFNMDAVKDTNSPYPMMLPSSAQFATYMAERGIRPDDVLVIYDTFETGLRLSPRVAWTCQHFGHKNVHVLINFANYVKEGFPVASGQMRTPVSSTTSEMDEATSIDPDPEADNVITFEHLRCMIKDPSQKGKFQIIDARPNDLFSGRAATNGASASVRLGHMPSAINVPFDSVLGLDKTFLPPAELRDQFVKSGVREDVPAVLTCNSGVTAAVVDLALRVAGLNVKTSLYDGSWSEWADRVDEDGLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7U8</accession>
    <name>A0A370P7U8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_279180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7U8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="61872" checksum="70CC58980C3D3536" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P882</accession>
    <name>A0A370P882_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_307699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P882"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="248" mass="26752" checksum="D4860BB5D5DBE082" modified="2018-11-07" version="1">MSATEQLDVANLAVYALFSLPAMYCLVVHGKHGLLGWAYVLAMCGLRIAGSAMSLNAIHRNEINTTAAILNGIGLSPLLMAAMSLLHEANHSIHRFLPPFLNLWGFFITHMVVAGGIGLAAASSGNETLLRVGMIVFATGWTLVAVLIWFSYGANAHSRRLGEERQKQLLSAITVAMPLIGVRIVYAIVTAFTSSNLEGGSLAVRVIFGTIPEYLVMLIYVGVGIVTRNLVRSRVEYTQPMNQSQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P968</accession>
    <name>A0A370P968_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_329676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P968"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="359" mass="40136" checksum="08F81F32D3651636" modified="2018-11-07" version="1">MGSTSSPGYDSSATRVPIIIGVCVPMVVLAILATALRIWARVMTNVKLWWDDWLCIVGLPFAILPSIFDFVQINNGFGRPMATVPADKLVTYSLFLYILMLFYNLGLAFFKLSCLALYIRMFGIHRWIRYMSYVIGVMVIAWVLANELVLAFRCHPIDLAWKGTAEQQAKFCVTQTNIFIAQSGPTIFFDLLILIMPIRVVWGLHLQSAQKLGAILVFSLGLLVTVISMIRLADTLHSTDTDLTYGYVELGMWSAVEPVTGLICCSLMTYGPFIKKLRQAGKGYIRGKSSHHRQSHSSNSFATQNKLTGHRSAEYDQSDLELTFCSFSNEAPVVGKADTFGKIHDGAINITHEFQVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9C3</accession>
    <name>A0A370P9C3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_306772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9C3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016893767" description="laccase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="67"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="406"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK38761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="62167" checksum="96B4AA8684E6B1AB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9M8</accession>
    <name>A0A370P9M8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_278766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9M8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="86"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="388" mass="43869" checksum="40B63CE83C1EB776" modified="2018-11-07" version="1">MALTQQQPASIPLDVFPDGLKTTGQHPPLYEHIHPFDKFPKEITGPTVWKPEDYSNNPEKWTHRFTAEEIEELSAAADAFLDAKIPMTGISKSNFPLPNLAARLHELRADLLDGKGFILFKGFPVEKWGNHKSAVAYMGLGTYLGYFVSQNSRGHVLGHVKDLGEDPTRIDSVRIYRTNARQFFHADDSDIVGLLCIHRAREGGESDLCSSHNVYNVLAKERPDVLKTLTEPIWYFDRKGETSTGQEEYIKTSVVYLERGENPRVYTKWDPYYVRSLTRFSDAGIIPPLSAAQVEALEVLEETCNRVKLHMILEVGDIQFLANSHVLHARTAYVDHAPPTPRRHLMRLWLATPESEGGWKLPFWDSNEKKRGGIQVDDQAPVAPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA07</accession>
    <name>A0A370PA07_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIP transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_338391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="34904" checksum="AC2B8EA75DAE3A02" modified="2018-11-07" version="1">MVVTYLPEYESDETHPQHHGLEPAIPPFAGRMGGNQDFVVDRTDPKNSKVLERVPDAAPCMTLKEIFDLRGFLSVDLWKFAVLECIASMMNVFITCWVTTHPLSATTSPKGQAGVYGTVTFFSPTFGGLTNLLLTPLLIYTFSPSSGGHISPTITLATFFARIITFPRMILYLAGQTLGGALAGFAMHSAYGTREFTVGGCHIDTTMVSAEDGLVIEFFACLILIFLAFGVALDPRQAKVFGHAVSPWLVGVVLGIVTWGTAFTREGYIGASVNPARCFGAYVASDFPTYHWIHWVGPLAAAVAHGLVYFVDPLWKDPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB48</accession>
    <name>A0A370PB48_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_338280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="472" mass="50563" checksum="A1AC2FEEDE6E73E6" modified="2018-11-07" version="1">MSYINEAKDLKVAPAPDASDDIRVASSSEVKVDDDSHEVFKQADGKVNFRTVSWIRASAIFLKMLFATGILSIPSVMYDLGAFPGAVNLVGWCVINAYGAIILGNFRTLYPQCHSVADMAQLIGGPMLRELVGFMFIVTYVITAASGIIGVSAAFNALSLHSLCTVWFSFIATIIIAGFASVRKFSHIGWLTWVGFVSILAAVLIVVIGVTTRSRPAIAPQTGPYDLGYHAIGSPSFAAGITASATIFVSSAATSAFLPVISEMRKPKDYPKAVYLCMSFVTSSYLAFALVIYAWCGKWIASPALGSAGTTIKRVAYGIALPGLIVSGSLYVHVAAKYLFVRILRHSRHLQANTVIHWGTWLGCTIGLAAIAFILACAIPIFTYVLALVGSLGFAPLALCLPGWLWVYSHGEYWKSGGVMKRVVYLLHILLILLGAFMTVGGTYGVIVQIMDAYRDGEIDGVFSCADNSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBA7</accession>
    <name>A0A370PBA7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b560 subunit of succinate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_255962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20140" checksum="08B6066396C60E53" modified="2018-11-07" version="1">MLSQKVAQQSLRRLAVQQPYALRWSLMNSVSPAAVALGRTVQTRHAATSSNSSDPTKLLAQQRLNRPVSPHLSIYRPQITWIGSSIHRITGIALSGSLYLYASAYLASPMLGWDLGSASAAAAFAALPVVAKVALKTTMALPFTYHCMNGVRHLIWDTGAGLTNPQVIKSGWTVVGLSTLSALILAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCG9</accession>
    <name>A0A370PCG9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_277825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="164" mass="16733" checksum="A7B088722DF21ED3" modified="2018-11-07" version="1">MVSEFCPSYGPFFGVLGCTSAIVFTSFGAAYGTAKAGVGVCSSGVLRPDLIVKNIVPIVMAGILGIYGLVVSVLIANNLAQEMTLYTSLLQLGAGLAVGLCGLAAGFAIGIVGDAGVRGTAQQSRLYVGMILILIFAEVLGLYGLIVALLMNSRASVIDFKCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCY5</accession>
    <name>A0A370PCY5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_320484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02670">
        <property type="entry name" value="Peptidase_C19N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="764" mass="85675" checksum="5FB05AF056949B69" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCY6</accession>
    <name>A0A370PCY6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_285420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCY6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="897" mass="100011" checksum="3B87F1A8C71A06E0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD72</accession>
    <name>A0A370PD72_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_238039</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="18">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="17">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK40117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="54571" checksum="66662D7F155A672F" modified="2018-11-07" version="1">MAVAVAKEEMDYSIKPEASASKIDTSEWPLLLKNYDKLLVRTGHFTPIPAGSTPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDENSGMVTLHDVLDAQWMYDNQRDESYLRKVIKPLETLLTTYKRIVVKDSAVNAVCYGAKLMVPGLLRFEAGIEVNEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEATPAKWKNDYKDYSAPEEEGAQAVAQPVAQEETATPAEQTETPSSPNKMDVDDDDDEKKKRKRHEGETPEERAERKRKKKEKKEKKERRKSKQEKEESDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDM9</accession>
    <name>A0A370PDM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="223" mass="24512" checksum="4A65EBBB9394AD24" modified="2018-11-07" version="1">MSAKLILPALSLFTLYAIWYYADANGLLELARESIERKTLPGSDAPLRTVYTGFPQLDHLLTTLTTFFWPTTDGSHPALTLHTLGFAGTFGSAWILITLESWRQGNAWTLAAFPLIFGLSAQTLTFAFAAPLYCALQLTTSITATSPTATNIYIPKTILTTLPLIFTLSYILPSSLMVLPLSSTITTDLKQLFIALWQPFPAYISILLTLSHTLFSPFTGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEI7</accession>
    <name>A0A370PEI7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_218462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="570" mass="61797" checksum="01B546FB8DC52173" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEW2</accession>
    <name>A0A370PEW2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_337217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="77867" checksum="314A380FAFD19343" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF43</accession>
    <name>A0A370PF43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_303530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016918134" description="Aspergillopepsin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29873" checksum="BE3C894BDC38BA60" modified="2018-11-07" version="1">MKFTNYLLTTATLASSVLTAPAPRTGLEDRLRARSLQRQSHPLAPIPLDTSTKENSRLLEADENTTHVTYSSNWAGAVREQPPPQGTYSAVSATFRVPEPTAQGGSGTQAGSAWVGIDGDTYSNAILQTGVDFYVENGQTYNDAWYEWYPDYAYDFDLDVSTGDTIVAKVEAISPSQGVATIENISTGKKATQTIRAPAATATLAGQNADWIVEDFQSGDSMVDLAGFGEISFWGVQAQGGGSTWGVDDATIVELKQGNEVLTDVEVQSDSAFTVKYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFN3</accession>
    <name>A0A370PFN3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_294664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26450" checksum="442EABF213475873" modified="2018-11-07" version="1">MLVFNIWTVAPRSRREGFIEKPIDYWLPGFESGIVYEKRQFYSAHSDYAGVGPEVDAKWYNLTRGAMGISRQQLTALNNHPDLAVRIENSGPEQEYMATFDVLHQLHCVDLLRKGIHMDYYKDRDEHFVNQTDERIFFHLDHCVDILRQTLMCHDDLSLVTYNWVKGLDVPYPNFNTYHTCKNWDTFLALNQKLDVSARWEDGKVVELYSIPRKPEHVDGMWPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFN9</accession>
    <name>A0A370PFN9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_319811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF2">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="6">
        <location>
            <begin position="547"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="803"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="845"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="893"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="935"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123597" checksum="59A88F0CE7ADAC17" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFQ7</accession>
    <name>A0A370PFQ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endoglucanase A eglA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_267810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFQ7"/>
    <dbReference type="SMR" id="A0A370PFQ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000004">
        <property type="entry name" value="Endoglucanase A eglA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016728352" evidence="5">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="25873" checksum="DEB79616A3F9C412" modified="2018-11-07" version="1">MKLPVTLAMLAATAMGQTMCSQYDSASSPPYSVNQNLWGEYQGTGSQCVYVDKLSSSGASWHTEWTWSGGEGTVKSYSNSGVTFNKKLVSDVSSIPTSVEWKQDNTNVNADVAYDLFTAANVDHATSSGDYELMIWLARYGNIQPIGKQIATATVGGKSWEVWYGSTTQAGAEQRTYSFVSESPINSYSGDINAFFSYLTQNQGFPASSQYLINLQFGTEAFTGGPATFTVDNWTASVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG61</accession>
    <name>A0A370PG61_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_302980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG61"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71633" checksum="51144D3C678E37B3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG87</accession>
    <name>A0A370PG87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_267503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="247" mass="27297" checksum="1F3D5FC8BC82EB51" modified="2018-11-07" version="1">MAISRYPLRGCGVSIRPSIEGLAQALFERLVFFFCSLVPDVCRYPFEGVVYLSRYRVSLREFDGLLVLVPALFEGLVALSQPLSPSGVRFILADIGEYTCLFASIMPCQHTDDNISVSLREFDGLLNLVNLANMDPSQFSERIWSSTSCSSSLRESGLQPLAVSPRESGLLLVCSCTETTASFCLRLSTSVNVRHVSTRDRRPIPLAVTEARIPLFAGLPPEYLVSEGRQPTTLPADIRNRQNGDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ2</accession>
    <name>A0A370PGJ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mis12-Mtw1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_25500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="65279" checksum="BE96DCE9B741047E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ3</accession>
    <name>A0A370PGJ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanamide hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000038">
        <property type="entry name" value="Cyanamide hydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF8">
        <property type="entry name" value="HYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="26937" checksum="6F023F4C604D3B1F" modified="2018-11-07" version="1">MCHDKIPLNGWTSTPANAGAIFPDKPFIHPPTPISITEIPFPSTDPLVAKTLEYVQSLLPRETVNHSMRVYYYGMILLTQQFPSHHLSPTTWALTCLLHDIGTAPSLLTSTNMSFDLYGGIKAHSVLTSFDCPADVADAVAEAIIRHQDLGVDGNITFLGQLIQLATIYDNVGEHPHVKDFGGLIHEDARREVNERWRREGWCGVFADVVKLEVGRKPWCHSTHIVGFEGKVRGNTLFGDLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGN0</accession>
    <name>A0A370PGN0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mismatched base pair and cruciform DNA recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_235579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGN0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16612" checksum="4EA1AAA68E25B671" modified="2018-11-07" version="1">MVQRAAGSLTGDSSAQSTGTATQAQGEAEHNASHNNFTKLGPVTADPATGAAATDHPQRSNGSWDQTVGSAKESLGNLIGNEGLRKAGQEQNAAGKQAEAEGQMRDWKEGVEGRAKGAVGKVAAAATGDEEEERKWRDVHDEGKVRQRGVESEVQKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGX5</accession>
    <name>A0A370PGX5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_217072</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGX5"/>
    <dbReference type="SMR" id="A0A370PGX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579728" description="alpha-amylase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="38"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="60942" checksum="F355F77E74F76C79" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH99</accession>
    <name>A0A370PH99_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_302044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF12">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="742"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2245"/>
            <end position="2321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2882" mass="318090" checksum="2BE427819E9DB10A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHG6</accession>
    <name>A0A370PHG6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_25833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="16093" checksum="E5A13DEE539306B1" modified="2018-11-07" version="1">MDSDGVITNFQCLCCASRYSFLCCLNECSLETYEVVVDTIFVPLLLTQPAFHRLPSHGNLRKHHLSHHAFSDVSPASIPSFVICEDRWSEFFSKWTRADQPSGHVESFSPRIRNDFLTRHWFVVTRQKYNTLPPASQLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI43</accession>
    <name>A0A370PI43_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_336701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="31946" checksum="A8AC6BCC01A468A2" modified="2018-11-07" version="1">MASHYLSTSPGTNIHFTITEAQSPSSPTPLLLFLHYWGGSSATWHKQTSPTSPHTLSNIYNTVTIDLRGWGQSTGPADSGASSKDYSITPMASDIVSILSHLQSTTSLLDNGVILVGHSMGAKVTLATLSKLSDNQLSLVKGLMLVAPAPPTPLVLPAEMSEQQRKAYDNEGSVRWTVQNVLSSVQNISGYDMELVIKDSLAGSSLARDGWILHGMQEDITSALDEVSTRLEGRKIKVGVLAGADDIVENKDRVEKEVAGALTKRGFEVQFEVLGGVKHLIPLESPESVARAIRSTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIF1</accession>
    <name>A0A370PIF1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_235210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIF1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="665" mass="74887" checksum="865B8C6B57897D1D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIK0</accession>
    <name>A0A370PIK0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_23628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="97"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="392" mass="42442" checksum="728D6D4AB564BBB7" modified="2018-11-07" version="1">MATEARDAAIRDAKRYVREIVRNDWVFEPSSEPGVPSFSSPPTPGQDVLHWRQREYDSSGSELEPQPSPAISPVGGQQQHNASELASPLGTPLSDDSERRRKRRRQMEEEMQWNKGLRTWVERRDAWSGALSRDEIRAREAKTQQAATPTTSSSELPQNASVPTAATPPLSASSANSQNDLALRTEASLSIAENDGALPRPPSRGEEPSTAAEQPPPPPPAGDDEKQGEESSSSADTGLTQSDSTHQQPSSEDPFIPVVSSLISNDNPIRASITPAMYPSIYSKVVIQGLTPTVPINLADVTKAMVQGWKSDGQWPPKPSSIVLQDTATVRPKPEEPADKPPSSPESKRRSGVASAVRKVFHFSGFHPHHPFHRRGSSSQQNEGGAEGGVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIK7</accession>
    <name>A0A370PIK7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_276714</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIK7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="111"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="410"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="58584" checksum="25992C14C5563638" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIY7</accession>
    <name>A0A370PIY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_301622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000004">
        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="283" mass="30293" checksum="8C37B70FAA14FAF6" modified="2018-11-07" version="1">MTSSITSPVVSITGKTRLQASLERATARQGPSMGQWLEFPGYSLARTVAHLGADWVLLDCEHGNIDDKAMYLQVGAISSAGVSPIVRIPASEPWMMKRALDCGAHAIMVPMCETKEQAEAIVRGCKYPSSQWPQGMRGAGAMFAPAAFNQSGREYLTHANDNVMIIVQIESRTAVENCAAIAAVPGIDMLFVGPNDLASSMGYFALDHAKIPEVQEATTHVLRVAKDAGKYAGHFALSADVAAAKYHQGFDFVNSGADIVALTSWMTAEMTKLRQLTDASAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ59</accession>
    <name>A0A370PJ59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_326862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480232" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="60284" checksum="F1DEA04F6088CE5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJK9</accession>
    <name>A0A370PJK9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_276302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="16697" checksum="27704DDCC8D122B3" modified="2018-11-07" version="1">MVVKGSCNCGRIRITMDNPTPSGGGVMICYCLNCRKQSGAAGTYVVVVENKDMVLTGRPKKFLDTNTACGRPLDRYFCYNCGCPIMYQSETVLPGKSLLMFGLFDDIPKPVAEVWTKRRPEWMVEVPDVLQYVTDIPDDVSGEEAKKLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJW0</accession>
    <name>A0A370PJW0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-glucanase/mutanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016828617" description="Alpha-1,3-glucanase/mutanase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111368" checksum="204FD0DDD548F1E5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK06</accession>
    <name>A0A370PK06_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_327050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="854"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
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            <end position="265"/>
        </location>
    </feature>
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        <location>
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            <end position="788"/>
        </location>
    </feature>
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            <end position="816"/>
        </location>
    </feature>
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        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="952" mass="103489" checksum="53AF14095E267E54" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK24</accession>
    <name>A0A370PK24_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK24"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34928" checksum="A9F466AB8F695E14" modified="2018-11-07" version="1">METLRGAIYGFPRPPPRIRTKPLQVICVGLPRSGTESLSRALTQLGFKTYHGWDIVFDEPPYAQGWAQLSERKYSGTQGAGTAPISRAEFDALLGHCDAVVDTAAAMFSVEMIQAYPEAKVILNTRQDVDAWHRSAMKTLVAEGEDQWMVWFLHIFTADMYWLWRLYYTFGYPGMFRGRTTKEGLTKHGKRVYQEHGLMIRGLVPEERLLEWDVEDGWGPLCEFLGKDIPDEPFPNTNNPAAFRKHIEDLVHPRAKRSLYNFACCATSAGVLVTAIVLGVKKRQLWQMLISEIPVVMGQCLESLSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK65</accession>
    <name>A0A370PK65_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">M752DRAFT_17937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="22213" checksum="339566373F5ABE42" modified="2018-11-07" version="1">MGGLGGIFNDPQMYQKLASNPKTSPLLADADFMAKLQRIQQNPNSVGQEIQDPRFLQVMSVLLGIDMSFGAPPEGASSAGAAPEAEEDVPMPDARPAAAEKKKEPEPAPEPEPEDEEAIAKKKAQEAADAEKKIGNDFYKKKQFDEAIEHYNKAWELHKDITYLNNLGAAKFEKGDLQGAIETCQKAIEEGRELRADFKALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK81</accession>
    <name>A0A370PK81_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="519" mass="56017" checksum="14C029E26E51399D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKC9</accession>
    <name>A0A370PKC9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_215636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="40097" checksum="3941C03490C77DD3" modified="2018-11-07" version="1">MPAFHRAVAAISRQAVFRGVQSQHVVARSISASALKSAIAHPITTHGPPPKAPSPTPANAELLQKDASSHQKSEKSPLPGKSSVLKKRFWKNVDVKRKSDGDYQVLLDTRPIRTPSKDVLSIPSTKPYLAHAIALEWDVMTTAQQALKNHLIPLTSLTARAADIAAEDARGETTTRDQIVKTAMRYLETDTLLCWVPEQNVYAADEVDADGKKPESLREAQIRVAKDTIAFLSTKVWPGVDIQPILDTDSILPASQPQATKDIILQWISGLQAYDLAGLERGVLAAKSLLIAVRLVAEWSETFREVQRPGRERFGIEEAAEASSLEVRWQTDMWGEVEDTHDVDKEDLKRQLGSVIVLVSGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKN1</accession>
    <name>A0A370PKN1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_335509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016614283" description="3-phytase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="61086" checksum="237D9E39794A9F0B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKX7</accession>
    <name>A0A370PKX7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="42973" checksum="A65C70DB1F10DFC1" modified="2018-11-07" version="1">MARYIMPLKDEQRLPEGAPAIAASFAEFQYQFEAFTHDWSSLVVAGSAALIPLLPIREDVSPTVSAAVERPEEYYYDSLSAYQEHRDVYCPEMAVSSYSAYEMRLFKYRKQNFEVFWESFDRSRVDMDYFKELREDRDLHPKNVKGLGRLILAEMVVSGRRPYTDYLTSRALKKLGDAQDPEFTGPTVYTRLEIPYTKRFTADRVRQFVARHSSIPFLFGTLNEILKGSGSAKPEEKELPGRLGFMKDNPGRQMIGSFYPLDEQGWAEAAYEVMDHLSDCEELSSGSEGTEYRRSEEEDSEEEDSEEEEIEKKDSEEEDSEEEDSEEQEIEEEDSEEEDSEKQDSKGPENREATDSSVVEHSNNTDVHRREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL84</accession>
    <name>A0A370PL84_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_250968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="498"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="589" mass="64970" checksum="79BEBF9A52688F57" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLA9</accession>
    <name>A0A370PLA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_251015</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLA9"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="71"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="414"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="608" mass="64653" checksum="1A69FFB5CED60D0F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLQ6</accession>
    <name>A0A370PLQ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_276200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="21720" checksum="7EAD9E2A79F617BD" modified="2018-11-07" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKMDLRHDPKTIEELHKTSQKPVTPEQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLTKTHKSKKKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM40</accession>
    <name>A0A370PM40_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_154614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="116" mass="12646" checksum="FD79A27C82986779" modified="2018-11-07" version="1">MVITTTITITTKEGGEGMKHNKRTSRTGKSLWTGRRDTVVRKKSHVAVIGFIWQAGHQSVSLSSSNPSTSGSAALVVLRSIRTPRLPIPVSLSILPSSVHFMTFYNILSFCLIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMF5</accession>
    <name>A0A370PMF5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_275603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="70" mass="7856" checksum="E7406862F6EC5296" modified="2018-11-07" version="1">MSDQVQELLNVPREFLREGVQFVNRSQKPDKREFIKISQAVGTGFLIMGFIGYIVKLIHIPVNNVLVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMN6</accession>
    <name>A0A370PMN6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_318748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="616" mass="68373" checksum="230D0C45DC77F349" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP1</accession>
    <name>A0A370PMP1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_157536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="33543" checksum="3A8659C19D4D8595" modified="2018-11-07" version="1">MAGIGGGSNYGPGGDSEFTTQNPWGSERTTTAEYYPGETTRTTTQQWTPITTSESSSQPTTTTATTTHSSSTSSSTSTTAVKSTSSTSSSSNNTKTIAIAVPVAVVGAAIIAALLFFILRRRRQQRTRSIIPQTNNDNPPVSMGAVPRQVRSPPQQRRPQLAANGATWEFAPTNSHDIPFTGPIPGRPVSGETEHIIPTNNQPRDFSPPTTNNHNFHTAATAAAAAGAGTAAAAAAEVPNRDNNSYERSPQPTMPAAWPSPEARLDRPISPFDHPLDDAVSEISRRSYTHARDMDDVSSVSSFEDDERRPAMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW7</accession>
    <name>A0A370PMW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54383" checksum="BE763403121BF859" modified="2018-11-07" version="1">MMAPPLHRRSWRQSRASALIFAAAFFSAGFILFFYSRPSYVAPIPDLETSPSLASPDDTNPCFVDLDLLRQYSSTATVQYARLEIAVTSTENFTGYTDTLSTRFPKFHTVRLDTEAPREDLSPEKCTATVTIEGPQPSAPPDASHIIFGLSTSTDRLIDSLDAFAHWAAGTNARILAVVDSGGRKKEAERRAQALGIRLTILQEDNERLDRYFYLVQYLYKHKDKSTQWVVMMDDDTFFPSMTRLVDRLATYDASMPQYVGAVTEDLQQMYSSGYMAYGGAGIFLTIPLLEQLQPWFDECYVFKGGGDHMLSQCIYKHTNTKLSWERDLFQLDLRGDASGFYEAGRAQPLSVHHWKSWFQADMVALSKASSICGEECLLHRWLLQDEWYLVNGFSVIKYSTVSDDPLAMEQTWNASQYTGPNPFTYSLGPLRRKDEKKISFRMRDVVQEKERVRQIYVHEVTPEELEVLEVVWNHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNA2</accession>
    <name>A0A370PNA2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM5</name>
        <name evidence="15" type="ORF">M752DRAFT_282648</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="196"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="14">
        <location>
            <begin position="1416"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="849"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1508"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="1546"/>
            <end position="1547"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="1574"/>
            <end position="1575"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1632"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK43669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1895" mass="213709" checksum="B66E511DDB75D450" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV6</accession>
    <name>A0A370PNV6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="763" mass="87482" checksum="71FE4BB3EAFE5609" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPR2</accession>
    <name>A0A370PPR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_136116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000125">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486422" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="61210" checksum="CCF4EE718DA109F7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPS5</accession>
    <name>A0A370PPS5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016746866" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="57" mass="6153" checksum="1148422EEF2AD3ED" modified="2018-11-07" version="1">MLAALGFPACAGSTFLFLTLFEFALNDSLFSVASPDCHCYPTFICPHFLSSSTTDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ48</accession>
    <name>A0A370PQ48_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_138246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="498" mass="56018" checksum="440E46562B5C6226" modified="2018-11-07" version="1">MSLKDVYQRFLANPNSAPLASDASLIYITTTTKLDGASAVVSHLTKQQRVVKTRSENVLDVIESANSLCLDIETTLEFVSGGGAYLPSLDDNFLADHVATFPTIHIVRFNSQNQIQNVRIYWDQASLLKQVEVIGSRSRSWPIREPKDQIRLIKSAISSNPGDDGPATSFPATTESSEERSKKGSPGKRHIKDPHAAESLFELLSPEKDRSDPVRAPRAPASAKPPPRDPKEIFHEDADVPDTPSRSRIAPKAGASKNFQRQRIFDDDETVAAEGGHEQIAYRANPKRFEHFELGGDNSEREIKEKPSRPVSRQAPHWDFDDFVTPEKPKRPLRGEQIRHFGWSDDEPDLTSPPAHPPVHRPRRDAETHFVLTDDPEEDKNAPRIISSFQNKGLSLYKNHLFQDEEEAADENAPLSVVNNGPNRKKDYETHWNITAESPQNSKVSSENMKPVPGDRQKALKNMQSSWDDPEQSPEKAAPPQRRAMRHLNQRSWDMGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ98</accession>
    <name>A0A370PQ98_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_291515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ98"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="122"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="47418" checksum="F9D8431D6AA5ADA6" modified="2018-11-07" version="1">MSFPSLDGNEPLPVRPRTASTTRASRGDSRRKSISFNIGGSESLPPSRSASVSDRRRSPSQVPAEREARPVVGAAVRGPSPPPPKTYERGVSFDTFDNPDAADFSLTLNYKHKGYQSTRRSRTFLCGTDQNDYSDFALEWLIDELVDDGDEIVCLRAVEKDSSIASDAAVEAGKYRKEAEKLFEQVIQKNTQNEKAISLVLELAVGKVQDIIQRMIRIYEPAILIVGTRGRNLGGMQGLLPGSVSKYCLQQSPIPVIVVRPTTKREKKKKKRLADPARRNYNHILEMSERRGSHIFDRSSSRDSSVSKLPDEEAAVAAALGLPSTYTHSRSSLSTSERSSVSHDESPSPLGSPDAASPSPLGGSVENSEIDTGSDDEPTVSHVEDRSDVTLSPKQTSETQEVPGLTEADAGAFTSSMNVPLIVTEDSSPDGTGKQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR18</accession>
    <name>A0A370PR18_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_212101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="656" mass="70915" checksum="5BED5BED3A994D17" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR76</accession>
    <name>A0A370PR76_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_291816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="26563" checksum="E230E8A61BA9C243" modified="2018-11-07" version="1">MSSSSSFTDKVYTITGLSGIGLAVARQLHAQGARLSLADISESALQHARAQLPNATDENVLTRVVDVGSCSSVEDWIDATVRHFGRLDGAANMAGMIGSKHGTGSLLEQDDAEWDMLLRVNLSGVMYCMRAQIRAIQGTSKTGSIVNAASIQGLRGFALHAAYSATKHGVVGLTRSVAKEVGPEIRVNSVAPGSIQTPLLDRATAIQGGFTPTPTVMPRVGTPDEVAHSVLFLLSDASSYTTGTALNVDGGWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRI8</accession>
    <name>A0A370PRI8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRI8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="14062" checksum="21BD227E4964FE4E" modified="2018-11-07" version="1">MISTAIQSLCETLSYYLIPSPEWSPFWDSLYDGLGTCMIVWIQLYFFGMSNNITIQLTGFIAMHLVTFPIVAWHAYYGDGWTEEAVDRCLGIVPVLVLDVVTVWFLYWRRGEKTDYNGPFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRS2</accession>
    <name>A0A370PRS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_142477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="186"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="780" mass="90290" checksum="E9244B3484A910B6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRW1</accession>
    <name>A0A370PRW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_274191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21698" checksum="5F360AD1BC65F03D" modified="2018-11-07" version="1">MTKFTFANSSEKVPGDGILPAQFSIRAAPSTDAWSKPPSTDTFTAPILYRSVPLKSFKRVRVAFNAVWQQNYDQGGLILVLNGAGGTRKWVKTGIELTRGRPHLSTVTKDNWADWSLQPVPSGGGAATLELVRESDNSLWIYLVEGIQKSPLREVTWVFEESDVQDFWVGLYAARPSKEGEDLVVNFGHLILDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRX4</accession>
    <name>A0A370PRX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_312741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="492" mass="54238" checksum="89E05EEA68381A11" modified="2018-11-07" version="1">MSNRTGDGVENLDVKADISELEYVKVNAPGNAGQTFSIEDENRVYRKLDWNLMPLIFVLYSLSVLDRSNLGNAKIAGMEDDIDLSGRRYDWLATAFYIAYILSQWTTIGWKAFPPHRWVAVTVFLWGFISTIQSACTNWAGLMICRVFLGIIEAMYGPGVPLYLSYFYPREKLGLRTGIFLSGAALANAYGSALAYGISQAKGSIGPWRILFIVEGVPSCLLAMVAWFCLPDSPKTAKFLDEREQEIAVALSLRQPGDRETHGLQLKQVLGSLLDYTSYPPALMYFGCNVCFASLPLFVPTIISEMGAFTTIQSNGLSAPPYVLCWIAIVVCAFLSDRVNLRGPFIVGGALIAAIGYIVLATQTTVAVRYFGLFLATQVFVSVALILTWVGNTHATDSKRAGAFAILATGGQCGPILGTNVFPDSDKPYYRKGMWISCGACLIVVIMGCWQMYLLWRANRHLDREYEQDGGDLSGNQSEGKNEADKPFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSB6</accession>
    <name>A0A370PSB6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_333731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="27014" checksum="E8A7DB417BB5CEB6" modified="2018-11-07" version="1">MASPNPKTKTIPLPGHFPNTTSDAQRVFDVLQLGGIAIVPTEIGYGLLASSVEAIERAFSAKRRQPGHAHGLIGSYELHHELHVLEPERFEMTRVLTHDLDMGLGIVAPYKADHPVLAKFTPKTLANVVKDDTIAMFVGGGSLLREICRLNYEAGQVMVGSSANLSGRGQKFLVEDIEEEIIEVADLIVDYGLQRYHVYGRASIVMDFGKMKVLRMGSCYELFRERMGRFWGVELPEDPVYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSF6</accession>
    <name>A0A370PSF6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_333978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11030">
        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="410" mass="45950" checksum="7E4E3CF7132CD5CF" modified="2018-11-07" version="1">MSQANTSDLPMYPFARPPKSYDPPAELAELRHQGPTERVQLFDGRPAWIVTRDKEVREMLSSDKFSNDRYNRDGYPEIHSGTKKDGVRPTFVHMDDPKHARHRAMTESFFTQEATEAVKPQVQEVVDSLIDSIKERGCNNGPIDLVKELATVVNPKVILLSILKVSEKEANELIQSSSALGGTSGSASESGHTDLHEYISQLIDARTEKPRRPQDDLLSKLVVDEYRQANLDRDDLVNLVYMIFVAGNSAIQSSIVLGVITLLQHQDQLEELKENPELAGRVVEEILRYHTPSALNSRRVTTTDLTLGGKKIKSGSGVIGSVRSANRDERVYPDADKFSIHRQVDPHQNLAFGHGPHNCQGQWLSRMELQAIFSSLFRKLPNLRLAIEPSELEYTSPTQNVGVLRLPVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSR1</accession>
    <name>A0A370PSR1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_291282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSR1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="529" mass="57931" checksum="EAC68E1CB5E59A31" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTU2</accession>
    <name>A0A370PTU2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_317570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTU2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="390" mass="43480" checksum="D98AE777FBCF189C" modified="2018-11-07" version="1">MAPRRKHKKSRLGCLECKRRRIKCDERRPVCSQCTISERTCEFAELPARCIRPARSRRQTPSMPASLTGETTDSTSTVAESDPPIEPAANMLHAELLYQLLTETIDSLNEQNSPEIVVSPAELIRCSLRASYLLNELLALAATHLSIIRSEQHVYYRTHATHLQNHALRFFHAMDNADDPEACVSRFFFSSILGLHTLCETLIFRDGDFNIFLDSFVHYLRLHQGVRAVIGDNWSMLSQTTSLGPTLGSAGRQLQTDGSLGPECSHLLALIRQSNLGPSITETYRQAIEALQAAMHSISPNRPGGACITGVFAWPASVPSEYIDLLALRSPDALAVLAHYGVVLHAYRQCWFLGDGGRYLIESINDYLGPAWSEWLAYPRQVLCAGSHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU88</accession>
    <name>A0A370PU88_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_273899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU88"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="496" mass="55238" checksum="E6BEDDB656FE6D6D" modified="2018-11-07" version="1">MEYPGEQKPDYRSPTQFGGSMDEGDSNDSALSLLDEKREKHLIRKIDLHIIPFVVLLYLFSFLDRVNIGNARLYGMEEDLGLVGDQYQVAVSILFVTYCLFEVPSNLVIKKLRPSRYIATISVLWGIIATLTGITQNYGGLIACRILLGVVEAGLFPGMVTYLTIFYSKREIALRTGYLFSSAAAAGAFGGLLAYGIGFMDGVAGLRGWRWIMIIEGIPTVILGVLSWFFLADDLDTAYYLDDEEKALVVRLRRRDVGQTSSAQKFHWADVKEGALDWRIYAFCIAQFGVDTMLYGYSTFLPTIIQGMGSWSTPEVQALTIPCYAVGAISYLIIAWASDRTQRRGVFTCIFAAISVVGYGILISDSSSGVHYFGALLIALGLYVAVGLPLAWLPTTLPRYGKRTFATGLQLTFGNVSGVMSPFLYKTNEAPRYVRGNAVTLSLVGFAGIVYGLMWWYYYGKNKRREQGLEDEKIVGMSEEEIEEMGDRNPRFRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUJ2</accession>
    <name>A0A370PUJ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_246978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="717" mass="81367" checksum="4154C3316310BC87" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUY2</accession>
    <name>A0A370PUY2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_95943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016845859" evidence="2">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="112" mass="11917" checksum="A20258DCEC5B1DB5" modified="2018-11-07" version="1">MQFLLLLAATLSLGAGTLASPAPVPNSLDSRAYHWHGCGAGIECHSASDCYASEDCLKLALGSTDNIHCGQDSYPTACWAVSQIFLVAFFLFIFCSLIVAVECKKHCSDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVH9</accession>
    <name>A0A370PVH9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_332810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="58857" checksum="98801E17755C94A4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVV8</accession>
    <name>A0A370PVV8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="130" mass="14751" checksum="54B43ED2A9C54732" modified="2018-11-07" version="1">MPGAVSIPYRQNTGKRDTTWNTTLHLDQSILHETQLPRCIQPQLNRSSALPQGPYGRSRGDQALFSPGLLKGGNSSEKKTNLEYCPDELTNGQQQDCLRTLNRLQNLKAWHLFFQKFLPDPKTKESGQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWD3</accession>
    <name>A0A370PWD3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_246378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="56770" checksum="077C7D3D7017FC7F" modified="2018-11-07" version="1">MGASYSKPDPRNYNSEEKRSHREWVEDADSCSLPLYTKESAQAPPPYHVRERASSLSLHHVQDWNETLLGNAKNRLAISSLASQPYTEVLANRPALQSDLHIFNIKVPIEGSPITNQRSSGRCWLFASTNVYRVPLMKAYNLKDFELSQAYLFYWDKLEKANWFFEQIITTADEDLSGRLVQKLLEDPVSDGGQWDMVVNLIEKYGLVPHDLYPDAYHAQNSSKMNWLLTAKLREQALVLRRLVRSGDAAGLADAKERFLKEIHSMVTLLLGPPPSPDEQFVWQYYDAEGKSKEIRLTPREFGRQATSLGAVRKGSVAPARLFSLVNDPRNEYNRLLTVERLGNVLEGRPLTYANVEMKILKQAVISMLKAGHPVFFGCDVGKFSNSTLGIMDLDIMDLTLGFNISLGMSKAQRLVSGESAMTHAMVITGVHIEDGKPVRWRVENSWGEAAGDKGWFVMTDRWMDEYTLQAVVDSDFVSSEVRAILDQSPKVLPRWDPMGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWH1</accession>
    <name>A0A370PWH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_281623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="462" mass="49511" checksum="80AA9699D3A54941" modified="2018-11-07" version="1">MNEKNDKEGCTLFSSPTEEVQQGATVTDDAVFGVISEEGPNYRNLGWMGTSILMMKTQIGLGVLSIPSAFDALGLIPGVICLIIIAVTMSWSGYMVGVFKLNHREVYGIDDATGLIFGPIGREILGIGLSLFLVFCGASGILGLSIALNAVSNHGACTAVFVAVAAIVVLGLASIRTLDRISVLAWVGLACMWTSILIVTIAVGIQNRPDAAPPGPWVSDYKIVNAPSFTDGISAISQFIFAYAGTPFFFPIVSEMRDPRHYTKSLTVCQTVVTVTYITIGTVVYYFCGSYVSSPALGSAGKSIKRIAYGISLPGLFVTSTISTHMASKYIFLRFMRGSKHLTVNTFVHWATWLACVFAVIVVAYIIASGIPIFGSLISLVGALLGTVQCFQPAGCMWLYDNWSKRKEQRPLRWIFMVCYSIFMIVIGTFLTVGGTYGAVVGIIASLKADGTSGPWTCADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWH6</accession>
    <name>A0A370PWH6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_209079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWH6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000968">
        <property type="entry name" value="Helicase and polymerase-containing protein TEBICHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="150"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="407"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="932" mass="102589" checksum="08163710D595CFA4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM8</accession>
    <name>A0A370PWM8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_273593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="32488" checksum="9554586201A0E556" modified="2018-11-07" version="1">MAPQLAWLGLGNMGRGMAKNLAAKGSLATPLIIYNRNITRAQEFQAATPNTTIANTVSEAVTKSDIIFTCVGDDAAIQSIIDASIASGSPLTDKLFVDCSTVHPDTTTSISEKLQAKGARFVASPVFGAPPMAAAGQVIPVLAGPREAVEQVKPYTTGVIAKAVVDFSDQPPAKASQLKILGNTFVLGMVESIAEGLVVADKCGLGTDALHQFFEAVFPGPYVAYSARMRSGDYHERKEPLFAVDLARKDARHAMDLAGKVGARMKGIELADDYMAKVKEHMGERGDVAGMYGAVRQEAGLKFENAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX87</accession>
    <name>A0A370PX87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_316878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000748">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="848" mass="92975" checksum="B28DBD7533FF5357" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXC5</accession>
    <name>A0A370PXC5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="196" mass="22588" checksum="CC204653A2561F0D" modified="2018-11-07" version="1">MICTLTPINLYNPSEYATLQHQRRICGWDYSDESILAWREKQDADLKTFFWIILPSKSGDEPIRAGHISLDAYTSPPDPGLAQADHSVLTIQSFFILPEYRAGGVGRRAMQLVEEMAVNDPRCSTVTVNALSKEYLENEEKRAFLKSMNAVPEFAAVLWYERLGYVRWKTEPRYPYQLPQGGDGMYEADFLRKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL2</accession>
    <name>A0A370PXL2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_66840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXL2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="127"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="523" mass="57175" checksum="8F52333280DA62AA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYC9</accession>
    <name>A0A370PYC9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_228278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="222"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="676" mass="76155" checksum="A91ED9BF12B5BA84" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYK6</accession>
    <name>A0A370PYK6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehyrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_323672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYK6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="31815" checksum="E4856B87A26AE0FD" modified="2018-11-07" version="1">MSKLFNAVTLLGAGTQGSRLAYMYRKQWSRQGRPVYLVDQSPAQLNLALATIQRLRASNPAGKEGKITSLTVDDLDPALRDSWLAIECVPEDLEYKRSVMLELDSRSHSQTIIASNSSSYSITDICNGLSLKADDRFVNLHSFWPPETTAIEIMGSSQTRPDIIPLLMKETQDHGFQPFHVRKSSTGYTFNRIWAAIKRETLLVLEEGIATPEEVDQIYKCVLKTPRGPCELMDIAGLDVILAVEEHYAKVRMGIPNAPRKYLREMIDRGDLGVKSGNGFFSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYK7</accession>
    <name>A0A370PYK7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_71976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYK7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF4">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="444" mass="46766" checksum="0B5C5C2D04125BFC" modified="2018-11-07" version="1">MGSILPPTNPPTYKTPWTPTPLIESTTLSRAAGCRIFLKLENIQPSGSFKSRAMGNQILSHLLKPENYHRPVHFYASSGGNAGLAAVCAARSLGYPCTVVVPVSTKPLMVQKLRNAGAADVIQYGETFSEAGQYMKDVVMNNKDNNDAESDDDVVKIALHPFDNEPIWQGNSTIIDELVDQVPPPVGEEEEKVHAGRALPVDAIVCSVGGGGLLNGLVMGIERHRAKAKVADDGAAKPVHLVAVETKGTDSLATALESNELVSLPKITSQATSLGAIKVSERTFQYAVKPPPGVKVHSAVFSDAEAARGVLRLVDDERLLVELACGVCVEAAVGGSSCASSSSSSSKMVAAGQKRKRGMDVGYVSKDEGYGDDRLSAGENEDDGPVPSLSLSASAGGMQSKLKELVPDLNADSRVVIIVCGGSNVTIDMAAEWRKMLADGWASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYL4</accession>
    <name>A0A370PYL4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_273016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYL4"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="595" mass="64987" checksum="F3FE4D730CBAFD53" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYP5</accession>
    <name>A0A370PYP5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SnRNP assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_245614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="231"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="617" mass="68937" checksum="329C50644A11D17C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0E0</accession>
    <name>A0A370Q0E0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_7710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0E0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712076" evidence="1">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="176"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="339" mass="34453" checksum="4BC7FB925D940960" modified="2018-11-07" version="1">MRYSLALGALCAAGALANNVDKRSYVTDWTIVTLTTTITEYPTPTVYENVAAQEASAAASSSSAAAVAAAAESSSSAAAAAAAAASASAEASSSAAAAAAAAAEASTSSVVTPVVETTAAATTAAAATTAAAEEVATSWTSAWTSAWTSSWSSAAAPTTTLATSTSSSASSTATNAYQSAVLYNHNVHRSNHSASSLEWSSDLESSAYTLAAKCVYEHDTSIDGGGYGQNIGYGVESSEIGVMITNLMYNDEMGYYTDLYGEADPDMTYFDNWGHFSQIVWAATTHVGCATVTCDSLGNVDASEALPFTVCNYSPAGNYEGEYGTNVKRPLGQAVYVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q153</accession>
    <name>A0A370Q153_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q153"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="61999" checksum="742719E4515F0913" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q170</accession>
    <name>A0A370Q170_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_244377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q170"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="264" mass="30545" checksum="6D4592858A5675B0" modified="2018-11-07" version="1">MEDFNSETDSDYTSYWRDWFISSRGNEYFCEIDEDYLTDRFNLTGLNTEVAYYQYALDLVTDVFDLDADDDLREQIEKSARHLYGLVHARYIVTTRGLAKMVEKYKRCDFGKCPRVMCDGHPLLPMGQHDVANQSTVRLYCPKCEDIYNPKSSRHASIDGAYFGTSFHSMLFQVYPALLPEKSIRRYEPRVFGFKVHAMAALARWQDIFREETKASLREAGVEAKYIEDDSEEEELDDDDEPISETKEERVAGDAASGRMDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3W4</accession>
    <name>A0A370P3W4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_311127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3W4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="270" mass="30445" checksum="53B1AE89FD44E832" modified="2018-11-07" version="1">MANYSAPVEGIAGGYTGNSLAVQAVLASLLACALYSSIELIILVFLTFHVYGGLYFWSLLVSTGLGIIPQAIGLLLKYFQLAPLWIPVTLSTFGWAVMVTGQSVVLYSRLHLILSNRTILRFVLYMIIFDAIILQIPQIILSYGAVYGGVRFAYVYNIWAKVQLTGFFVQEVIISTIFILQTFRLLYLYPHRSKRRTNIMEQLLAINTAIILMDISLLTLEYLDLFILQTSLKTFFYTVKLKLEFAVLSRLVSFVHYDPELESSTFTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Z9</accession>
    <name>A0A370P3Z9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_299129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Z9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="41665" checksum="0B969E9EAE756A07" modified="2018-11-07" version="1">MPLVHLPPELVPIIAGHLKSEIDLNCFAQTSQCLYRWVNPCLYQCAVRTMGESLLHWAASKGQLQTLLKLLAFGAKLPANNQNTTTDSHPISTAATYGCVNIIDVLLDLGTDIEYPAGVHGDTPLMIAVREGHLPVVRRLLERGANPTLPNKLDHSPLEVAIIAGSLAVTERLISHVKDLPHTAEVDSLGRALCAAARSRQVDIVKMLLCNGAPVNYIHHQQLETALINATRTGDNEITRLLLDHGADPMIGFETWDSPALACAAWRNHQSIVEMLVKKDPRVGRHFADAMVEAANLGLEDMASYFLLKGANPDHLRSGYRTPLSCAAQHGHVGVVRVLLTAGADPEANDNHGRTPNWYASWLGCPEVLALLREHITPGACQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4A2</accession>
    <name>A0A370P4A2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_331052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4A2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="53857" checksum="AB01AB9E37D8C85C" modified="2018-11-07" version="1">MDTDLDVVIVGAGISGINAAYRIQSQFPNYRYTILEARDALGGTWDFFKYPGIRSDSDLFSFGFSWFPWDGNSPIAEAPSIVSYLHRATRKHGIDKKIRYQHRLLGADWSSSDQLWSLTVDHDGQSRALTARFVIFGTGYYDYRQPLEADIPNLSRFTGEVIHPQFWPESLDYSNKNIVVVGSGATAITLIPKLAEKAARVTMLQRSPTYILSLPNSNRSWYSYILPAALSRRIQRITWFISGHLFFLFCRTFPTIARFLLRLSVSGQLPAHVPHSPHFKPRYNPWDQRLCICPDGDFFRALHTGHADVKTDTISTVTESGVELSSGGSLSADIIVTATGLRLLMAGGASVTVDGEPIHIPSKFLWHGMMMQDLPNAAFVIGYTNASWTLGADATALFVCRLLKQLETAGAKVAIPRLQPGEAGSLKERPLLNLNSTYITRASGALPKAADRGPWVSRGNYLRDVWFAEHGNLDGLVFEGGKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4E0</accession>
    <name>A0A370P4E0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_112160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4E0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000020">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="189" mass="21159" checksum="1E03359A2F8C0A95" modified="2018-11-07" version="1">MSLDTPASSLSASDPHARLLGASCLDFLLIELVPMAERLAKELASEEKLPDDEEIRETTFFRLESLGYRVGQGLAERFSRDRPRFADNLDIIKFLCKDLWTILFKKQVDNLKTNHRGVYVLTDNSFRPFARMSTSVRSEAVSMAQAYLWFPCGVIRGALSNLGITTTVQAESTELPGATFQIKTVNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Z7</accession>
    <name>A0A370P4Z7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_298807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Z7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="32489" checksum="9D5F7D5046424F1E" modified="2018-11-07" version="1">MSLPFQVVEEANQPFLKSCRHGDLAQVKEHRKAKALDQEVLTLGLREAAQGDHIETMRYLLNAGAKPQSPTVVDEVHSAEAVKALLDNGLTFETQLHPLGTVPLVHIVKKNDQRLVHWCLEQGADPTFGCPNALSLNDLEKPDQSPTKGSGAVLGMASRRSIPEIVDLLLDHGANIHNSNVLHYAACRRRGLAIPMMEHLIQRGADVNEFGYPAFLHFGGTPLHAASYQGNLLAVKWLLEHGANPGVEDAQGSKPLDLAALEEEDEICDVLYEWSRLDDAGKGENGSSDQPKANSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P539</accession>
    <name>A0A370P539_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_242318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P539"/>
    <dbReference type="SMR" id="A0A370P539"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="137" mass="15337" checksum="FEE2B636D9BEE4DF" modified="2018-11-07" version="1">MPLQGIRTVTAARNGVGAFILQCKRLDFHYCDWAGSSRGMVAYLKHHLPAFAKANPQIEIRVSPRPHKHPVIKGHYINGREKAVCVRNLEPEQIGKKADLLKQASGEKLKRTKKPVTSINESVRGIWSPYHGGYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P562</accession>
    <name>A0A370P562_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_259443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P562"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="164"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="303"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="585" mass="63851" checksum="55A9F0F088DAA687" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5L1</accession>
    <name>A0A370P5L1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_330671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5L1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="476"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="82389" checksum="6CB8060464EE6061" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5X8</accession>
    <name>A0A370P5X8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_309379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="594" mass="67261" checksum="201FFE963100082F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6D4</accession>
    <name>A0A370P6D4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_91672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6D4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="39210" checksum="CEEB7ED6A3A4A79B" modified="2018-11-07" version="1">MPALAGLSALERLPVEIIQEIFLHCLEVNLPRASIHISRALSNTVLYTWVTRYVFSSTNESSRQDFFTPDFLPWPLDVFALSPNERRDLQNVILSCRWCTLPLIRKCQREYIEHTIRRKCLQLDLSPGDRQVLINIGEQFDKDLPLMPDETPHAHRGKGDLILKAKIPKSDVDCKVAVWFNAGAVQIRPSSEIYQETDIFRLPCFAANLPVRVPDKLLFPPWTESKLDFLELLSMDGYLDEDPEHPRAKRILRQTIRDRDLATFKRLLSMRIRVPWYKYPIRWPVLPNHFYVALKYADEVEDPFVRLLVSQRWEDIPSDDFQLKDQLMAKLGTGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6P3</accession>
    <name>A0A370P6P3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_339591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6P3"/>
    <dbReference type="SMR" id="A0A370P6P3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="292" mass="32274" checksum="9B4B3A68283489D8" modified="2018-11-07" version="1">MPNSAQNLPRVRACLFDMDGLLIDSEDKYTDITNAILQEYGKPLLPWSIKAQLQGRPQPDASRIFHHWAQLPISPEEYAAKQSALQEKFFPQSQPLPGVRDLLAKLVSTQTTDQPVHLALATSSHSRNFKLKASHLGDLFSAFPKSQQVLGDDPRIGKGRGKPLPDIYLLALETINTNLREKGETEIKPEECLVFEDAVPGVEAGRRAGMRVVWVPHPGLLESYKGREDEVLAGLTGEHKEAEKTEPEREADEIVAGRLKSAGKPGEIGDGLGELLPSLENFPYERYGIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6P8</accession>
    <name>A0A370P6P8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_258555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6P8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="94"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="390"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="843" mass="91919" checksum="D7D10E73233F13C7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6V6</accession>
    <name>A0A370P6V6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_308994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6V6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000061">
        <property type="entry name" value="Aspergillus niger contig An11c0010, genomic contig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="426" mass="46543" checksum="14A883A35F7B073A" modified="2018-11-07" version="1">MPNGQSSVEDRLQRLMPSLSVYSEGTHYQDCLELYNHALRKKPLVCTRPRTEEEVSRLVQFCAEQKIPFAVRSGGHDFFGRYVIHNGILIDMRDMDTVSVASDRASARVGGGVIAGHLQETLHSHGLFTPTGQAKTVGYVSWACGGGYGFYVGTYGFGVDQILGARVVLAGGGVVDTNEDSELLWALRGAGAGTFGIVVELRVKVYPVPKLYAGFLAFPLADAATVMGRIERLLDDDFPDEFSGDAIVQMMQAGRVLGNTVTETTPAAYGLGDSSSETFFRSRNVDRIHQKVGTILARHPPPYPLSAVIFHNNHGKGVRHQVADPVGAAFPNRYQHVILGLHGGTRPGGVDEQELATAARWVIQLEEAIDQNGLSLRGGFPAFWPPDQVDIERFFGQENALRLRQLKARLDPNNLFHRALPGLYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7U0</accession>
    <name>A0A370P7U0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_279190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7U0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="57326" checksum="0AB9E173EF9A3A39" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7V0</accession>
    <name>A0A370P7V0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_308117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7V0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016580404" description="DUF7029 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="821" mass="88749" checksum="D33AA231DAD90F89" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8R4</accession>
    <name>A0A370P8R4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_329748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8R4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="56372" checksum="709C2759CE9EA429" modified="2018-11-07" version="1">MQRPAQPSASAAGKIQKIVNSMGDSKMPNDNSAPQACIACKKRKGKCDRAFPSCSYCKRRSQPCYYHAVGFGSLFPSHTACFPPAYFLDHDHLETLAPKLPPVSLEVPPWVWSEIGDIQQQKEIASQFFSTIHLWMPIVSKKLFMDYLLYPLPFDRADMAVLCLAMKLAIWIPSANSPDPQTTTYIVTRQLLFGNVISRALTLPALQASVLIAVYEVGHAIYPAAHLSITTCANYAMTLGLGWKNSCWEECTQSWIKAEERRRVWWAIVILERYISLGWQACPIISEGPGIDEVLPIYDAAWDEGVMVSGHSMTTSTPCNVNMGRFARLAQGTYLLDRVLRHTHDRTMSAKSREEEAIQLDKTLRALVVFTASETERRDMKICSQTALCQSALAILHAPYLSPSSGASKYRRSLARNAMNQLSHEFLGESKRILHGAGLHFEATSPLSFHWGYMASAHFALLSQADPQSDASSAQETVHSALKMGNARWRAAGAYLGILDARQAMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8T2</accession>
    <name>A0A370P8T2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_307180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8T2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="832" mass="90135" checksum="FAA491781B1CF932" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P995</accession>
    <name>A0A370P995_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_306756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="9">
        <location>
            <begin position="426"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="950"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1173"/>
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        </location>
    </feature>
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            <begin position="1244"/>
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        </location>
    </feature>
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        <location>
            <begin position="1286"/>
            <end position="1327"/>
        </location>
    </feature>
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            <begin position="16"/>
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        </location>
    </feature>
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            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
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            <begin position="45"/>
            <end position="62"/>
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    </feature>
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        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1460" mass="165826" checksum="9F1E2886D2B68C3C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9F5</accession>
    <name>A0A370P9F5_ASPPH</name>
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        <submittedName>
            <fullName evidence="3">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_269395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="213" mass="22326" checksum="FB4A3121B9B6678F" modified="2018-11-07" version="1">MQLFRLLPPVALGSALATADIVTYSPPTEPGLSYSVTIPNTTTAAGSGPIYLQISAPTTLQWVSLGEGAQMASANLFILWAASPTDVTLSPRSSLDGGQSEPQYNSLANVTLLPGSGIDNGVMIANIRCDNCLSAWPTPAAPLSDPSSTYTLDPEGASTPWFWASYTGPPLNNPDPSADLAMHDDLGSMQLDLSRAQFSVFGAMADPSYNPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9J7</accession>
    <name>A0A370P9J7_ASPPH</name>
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        <submittedName>
            <fullName evidence="5">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_286032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000055">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000125">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="130"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="451"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="815" mass="92554" checksum="EF9E214772DE3928" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9V8</accession>
    <name>A0A370P9V8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9V8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="99" mass="10152" checksum="20D2F90AA6933036" modified="2018-11-07" version="1">MSEHTTRKYGDLESRGAEATGRQAISTGLFNSRTGAAGGDVNGGDGGKISIAKEHNFVETANINVSGGNAHQTGYHARGFHHVQTSGNVKGGNGGTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9V9</accession>
    <name>A0A370P9V9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_307048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9V9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016978239" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="39201" checksum="15B2AA233C06CFB5" modified="2018-11-07" version="1">MIIKSFLTLAIFASASGLAINKRFDNGDFPTGDTDPNVTSALTTTVSSTKAVSTVSSSLLSTTTAAPASGTTTGAGSPSPTQSGLSSSCDAFYYVEAGDSCWAIVNSYGNFTLNQFYSWNPAVKSDCSGLQPDYYVCIGVAGSTTVASQTTLPATTTALAATSTGSYLPEQTGIAPNCNRYYYVQHGDTCSDIATNQDISLNDFYSWNPAVGTTCSDLEADYWVCVGVSGGATATTTTSTSTSISTVGSTTPTSNAPSPTQSGLVGDCSTYYEAKSGDSCWSIVNDKYTYLTTSLFEEWNPAVGSDCGNLQPGYYYCVATQKQAPMPDTIHTCKKWHLVSDGDNCWLIEQDAGVTASQFNTWNPITPNVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAU9</accession>
    <name>A0A370PAU9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_305582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAU9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="519"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111963" checksum="663369907421E0D0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW7</accession>
    <name>A0A370PAW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_238639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK39333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
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        <location>
            <begin position="95"/>
            <end position="560"/>
        </location>
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        <location>
            <position position="328"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63221" checksum="A78680BB2D229A82" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW8</accession>
    <name>A0A370PAW8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_296375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017083696" description="Arylsulfotransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72627" checksum="D14798190B585EE7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB87</accession>
    <name>A0A370PB87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="31802" checksum="D7A9FEEF5DDA76D1" modified="2018-11-07" version="1">MSANPSTDDNPSAAGSPPQVPETREPQQQQQHEESPTAEETTPGPETKEREETEPTSEREPGEEPEAAAATESDSAPPLPDEVPPPLPNEAPPGDNKDDGWEPVWDPTAQAYYFYNRFTGVSQWENPRVPDATAKADDNTAAEDADAAGPSSSAAAAATTAVVGGYNPAIHGDYDPTAPYAQQYEQHNQDTAGGGALDPEKAYEAVGAFNRFTGRWQAESQNTEYHNDENKSHRQMYAFFDVDAAANSHDGRSLRAERSAKKLTKKELKMFKEKRREKKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBJ6</accession>
    <name>A0A370PBJ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_338169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33447" checksum="D1651D2CD2565A16" modified="2018-11-07" version="1">MRPRTLLLTIDAFNTIFHPRHPVPEQYISAFNSFKLQPSQAHELTPSILQPAFKSAYKAQSRRRPNYGRADAIRGQYGGPRQWWEELIRATFQQVLADQSTKLPDELIQGLLDRFASSQGYALYDDAGVLFERLRQIKTTGQKLGVFERVVVGVLSNSDDRVPAVLQSLGLSVGKGRADQEIESLKLPGFEDPSSISTDAYGEKVDDIDLVITSYQAGEEKPSPVIFDVAERQARRLVGAGEEEVDWVRVHVGDDYDKDYRAAVDAGWNGVYVPRDEGGGREGVVIRSLVDLVPMLEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBX0</accession>
    <name>A0A370PBX0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_304883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBX0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="147"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="637" mass="72551" checksum="35A300344484207F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC37</accession>
    <name>A0A370PC37_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_52232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC37"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="371"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="548"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="836" mass="95239" checksum="AFD1BCE11FB46828" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC42</accession>
    <name>A0A370PC42_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="147" mass="16725" checksum="089E1CEB0425B064" modified="2018-11-07" version="1">MSLLPHHPRPVPSLLRAFTDLDNYLTSTSTAADSLFPNSPRFDLRETKDAYILDGDLPGVKKEDVTIEFSDPSTMNVRGRSVRSTEGEDGNWWFSERAMGEFRRSFSFPAKVDREHVDAKLTDGVLSIQVPKVEEEPEEERKIVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC47</accession>
    <name>A0A370PC47_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_320666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="51774" checksum="03816E30322B4B91" modified="2018-11-07" version="1">MSVPNITTISPITNRPILNRTGANPEDIVGIAESAQEAYRSFSESTTLKQRQDIVTRALDKLEKRKDDLARQITEQMGRPISYTGVEVATAIKRSHYLNRISDSVLGEAGIVPGEEEQGFKRYIKRKPVGVVLIIFAWNYPYLVLVNSLIPAILAGNAVILKPSPQTPTIAEEVANAFEEAGLPENVIQYVHSGSPTLLESLVRSSCVNHICFTGSVEGGLATQKAASDRIVNLGLELGGKDPAYVRDDVDIPWAAAEIVDGAIFNSGQSCCAIERVYVHQNIYDQFVAEVKMVLSNYVVGDPFDKKTQIGPVISKRAKEEIEAHIADAVEKGAKDETPANETFENPPPEGNYVKPTLLTGVTHEMRVMTEETFGPVIPVMKVEGDDEAVKWMNSSEFGLTASVWTKDVAAAEELVERVEAGTVFINRSDYPSPDLAWTGWKNSGRGVTLSRFGFEQFVKLKSYHIKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCX9</accession>
    <name>A0A370PCX9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenosine kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_255017</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCX9"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="38290" checksum="40357E9FF1A6DB06" modified="2018-11-07" version="1">MAAPQGYPLLCLENPLLDIQAVGDAALLQKYGLKDNDAILAEDQHMGLYDELFAKNDVKLIAGGAAQNTARGAQYALPANSVCYIGCVGRDKYAEILKEACEQAGVHTEYRVDDAQPTGKCGVIITGHNRSMCTHLAAANEYKIEHLKQPHVWSLVEKAQFYYVGGFHLTVCVPAIQALGEEAAAKNKVFMLNLSAPFIAQFFKDQLDSVLPYTDYTFCNETEARAFSESHSWGTDDVVEIAKKLAQLPKKNTNRPRVAIVTQGTLPTVAATVKPNGEVEVKEIPVREIPKSSINDTNGAGDAFCGGFCAGIVQGKSLEDSIDMGQWLASLSIQELGASFPFPKQAYTPINRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD17</accession>
    <name>A0A370PD17_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_219523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="851" mass="94132" checksum="010A725EFD368B9A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD63</accession>
    <name>A0A370PD63_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="62925" checksum="7D61CAACD8AB8A8A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD67</accession>
    <name>A0A370PD67_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rheb small monomeric GTPase RhbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_328742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD67"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20927" checksum="DBD9B9A2E7180B49" modified="2018-11-07" version="1">MPSAPKQRKIAIVGSRSVGKSSLTVRFVEHHFVESYYPTIENTFSRIIKYNGQDYATEIVDTAGQDEYSILNSKHFIGIHGYIIVYSVASRQSFDMVRVIRDKILNHLGADHVPLVLVGNKSDLKSEQRQVSLDEGRQLCEEFHCAFTEASARLDYNVAKAFDLMIGEIEKSQNPSQPAGGNKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDJ6</accession>
    <name>A0A370PDJ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TOK2 potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_303789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="59606" checksum="B0F4934B6354A6D0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE38</accession>
    <name>A0A370PE38_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-galactose dehydrogenase (L-GalDH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_277734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="50540" checksum="DF640A59D64B5695" modified="2018-11-07" version="1">MPRPSTPLSAALPPLIMGTATFNNQYNHDPFALPTTELVQRAFTSGIRAFDTSPYYGPAEELLGRALATDYVRTHHPRSSYHILTKVGRIASSSFDYSPAWVRQSVRRSLQRLHTDYLDVVYCHDVEFVSRQEALTAIRELRRIRDTEGTIKYVGISGFPIDVLAEIAELVLRETGEPLDIVQSYANYTLQNTRLLSRGLPRFVSAGVDVVTNASPLGMGLLRRQGVPIGSMGDFHPAPDGLRNKIREVSEWVDGQGEKLEVVAIRFALESWLREGKQVGALGAPLVRVGDADPGFISVAGMGTGERLGVSVMGVSNFEELDETLRVWHSIVDGLEIKDDDDDVEPKSSELQPPSAVPSAAQAPAILTPSEGIITDRAWSKDRRGRISSLAQHIRTILGPEWADYAWDSPSPDFVNSLSAEHLAARDKDDAAAASDEPMITPPLEAVDADEKIPTGAAPDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF00</accession>
    <name>A0A370PF00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_236816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF71">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G02650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="521" mass="57361" checksum="3B509739F7ACE493" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF01</accession>
    <name>A0A370PF01_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF01"/>
    <dbReference type="SMR" id="A0A370PF01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12587" checksum="00DD1BF6E38334AD" modified="2018-11-07" version="1">MTYTITVVFPNETDAQYDIDYYTNVHMRLIEKHWSKYGLKSWSVTKFGPSLDGTAPVYAVGSRVHWESEEGMKRAFESPEVPEIMGDVVHFSNKQPIFLFGETVQPSPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFF1</accession>
    <name>A0A370PFF1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_327730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFF1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="104"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="32565" checksum="1262281E846DB583" modified="2018-11-07" version="1">MASARSLMRLGSGRSLATAVRSSRTFTTTALKATQASTAPISEDVPNMRQAQRPPPGPLRAPIVNPADKYQDKADSLHKYGQYIMSCLPKHVQQFSVWKDELCIYVPPSGLIPTMTFLKYHTAAEYTQISDITGVDFPTRDQRFEVVYNMLSVRYNSRIRVKTYADEASPVPSVTGLFEGALWYEREVYDMFGVFFTGHPDLRRIMTDYGFDGHPLRKDFPLTGYTELRYCEEKKRIVIEPLELTQAFRNFEGGTAAWEPVSAGTDRTPESFKLPTPKPEPKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG95</accession>
    <name>A0A370PG95_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_253384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG95"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="59293" checksum="65E77C6FE4835E1B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGG1</accession>
    <name>A0A370PGG1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_217611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGG1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="219" mass="24525" checksum="7DF69C53E976B03D" modified="2018-11-07" version="1">MSLARAGRFACLRAGRLATPVNARFVSTGTGRGDPSRTSSTSDAPTVPHTESTLIRKESPSEAMTRHQPDYDATIDHGTSQFSPVPKRVMDGSEPGATVAAAVLSGAPTDLQARTVRIYRQAKPATQSGTWHGHHWRMDWDILQRGHRWENPLMGWQSSADCMQGTHLNFKSKEDAILFAQKQGYEYFVQEPNERRFVPKAYANNFVHEPKKLKYIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGT0</accession>
    <name>A0A370PGT0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_252746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="423" mass="45584" checksum="24550480E07738E6" modified="2018-11-07" version="1">MSTGVPISPVIIEEAQGTCLYDTNDRRILDFTSGQMSSLLGHSHPEIVSTIQQYAAKLDHLLSNMITHPVVDLAERLARYLPLPLEKSFFVNTGSESIEAAIKMAKAYTGKFEIVAFSASYHGLTQGSGSATYSTGRKCGGPCMPGQLAFPAPYAYRSPFRKADGTYDWETELMFGWSMIDRQSVGSLAAFVMEPILSTGGILELPDAYLQRMALECKKRGMLLIMDEAQTGVGRTGQMFAFEQAGIIPDILALSKTLGCGLPLASVSTSADIAQGCADAGFLWLTTHLNDPLTAAVGNKVLEIVERDNICQRATERGTQLREGLLKLQEKYWCIGDVRGRGLLQGIEIISDRDTQAPGPELGQAVSDRAMACGLSCNVVNLPGMGGVFRLAPPVTVSAQEIEEGLRILDEAFAYVLGKSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGV0</accession>
    <name>A0A370PGV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_276890</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGV0"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK41425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="252" mass="27253" checksum="7E970374F3811864" modified="2018-11-07" version="1">MSPPAIIAPSILSADFGTLGSECSTKIAQGSDWLHVDIMDGHFVPNMTFGAPVVTKIRSHVARPTEPNGKGTFDCHMMIQEPHKWVKDFKDAGCDLYCFHYEAAISSTAATSPADNTTTTKTSPKDLIRYIHDEGMQAGIAIKPDTPVDVLWDILANENEKERPDMVLVMTVHPGFGGQKFMASELPKVKALREKYPNLNIEVDGGLGLGTIDQAAEAGANVIVAGSAVFGAQDPADVIAKLRETVNKYRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHG8</accession>
    <name>A0A370PHG8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_327664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHG8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="55583" checksum="187BE1CA887D9C9F" modified="2018-11-07" version="1">MGSAEKKQLILNAFAMQSPSHLNPGLHRYPKDQGHNYTSLQNWIRVAQKLEAAKFHAIFFADVLGGYDVYKGPANLDPTIPAGAQFPINDPLYSIPAMAAATETIAFGVTASTTYDAPYAMARRFSTVDHLSNGRVGWNIVTSYLESAARNFGLNTQIEHDERYRIADEYLDVTYKLWEGSWRDGAVYKGADRDGVKGYADPKAVRQIHHKGKYFNVPGPHLCEPSPQRTPFLLQAGTSSAGKAFAAKHAEAIFLNGQTPELVRPSVDSVREQAKALGRDPAGIKIVAGVLVIVAETDEAAHAKFEEYAKYGDREGALALFGGWSGYDLSTYSDDQDFRFVEQPAVRSMVNHWASTVPGMEGKKWNKKTIANYLIMGGNGCKIIGGPKTVADELERWVEVADVDGFNLSYASIPETFDDIIQYLVPELQARGIFHKEYAVKGGTMRENMTEQKGQTRLPESHPGAKYFWREGEEVPKYAEVISRNITIPVAVKSQPYDSSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHK0</accession>
    <name>A0A370PHK0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_284415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="834" mass="93915" checksum="34C5223873B5AB6D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHU9</accession>
    <name>A0A370PHU9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_319370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHU9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="509" mass="57908" checksum="EBD46AF7B6696219" modified="2018-11-07" version="1">MLPRNIRTASFSAGDDLDCPTTGERSSHSHPQGFPQNKTSGHISKNVSGLPLSITENSLIVSNSESTPHRKEDGIRQNTVKDAKFLPKKRKWGPHIPPVGNIDMAEAYIAQKECYEQQKLIAADRLKVQRLRATMWEQREEETALRDSIRSHLSNITCCNCQSTAELIEKDYAALRSIAHYYLDLEYQYNQSEDDLKELEHELTRSAARLSRLFHPVDDRKPQGVRTDRGAARPSFHSRSFDSQSVPLTTSERKDSQQQPQPVTSQVQESILFDDAEKDSDSFSQRSMRSVSPDHSSRRDWDKTEARPRYDIADFESDLDEIAQSAPGSPRDAARSFGVRSHSAPDLVKDPFKLELYEKSSPFEQNDFDSPESPFQRRKFIDNWILHQVRTSSLESARLRSQPEWETLRAQGLTDEEISQLALECWHSHDPGAVVSSGSTIKPSRKSEQASTVIWRGTCRSFNHRKRTNSMAFGARPQLRRMSRYDPAWRGFGPDDEGSQSGDVAKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHX3</accession>
    <name>A0A370PHX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_293790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="53767" checksum="C1B1E8EA272E2173" modified="2018-11-07" version="1">MSPPPEKMIPSETDQESGEYPTLVEFDGPDDPLLPFNWSITRRVWVTSVVAILNLIGTVASSIFETGNETFMQDFNISHEVAVLGTSLFLVGYIFGFLTFGPLSERFGRKWPMLLGITLSSLFDLMPALGHNLPTVLLGRFFGGLFGVAPVAIFGGVISDCWPMAHRGIAMALAVSLVFSGPTFGPVSGGFIMSSSTLDWRWNMWVVIIVGLGASLLCAFVYPETYAPVILRKKGQALKRKTGNLDIKTAADKEGISLQEIARAYLIRPFWLFTTQPILALLTLYQSFIYGVLFLFYQTYPVVFGEDRGWPTALKYLPLLAIICGVFAGAFGIIIHNQVYFRHHCHAPDGVTFIPEARLPPMIVGGILVPIGMFWFAGTATPATIPWPSAICASFLIGAGMYLLFIQGFNYIVDNYTSMANSAMGVNGSMRSIFGAAFPLFANQMVDGLGVQRATIVLAAICVALVPVPVCFWYWGDRIRAWSSAKVPDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI87</accession>
    <name>A0A370PI87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_276606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="124" mass="13781" checksum="944E5F745E817D29" modified="2018-11-07" version="1">MAAPAVSYKDRQFLAVIGDEDSVTGLLLAGVGHVTDGADAQRNFLVVDSKTETATIEKAFQNFTQERKDIAIVLINQHIAERIRHSVDSYAEAFPAVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIP0</accession>
    <name>A0A370PIP0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_294044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIP0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="33129" checksum="B1010956B2F834D5" modified="2018-11-07" version="1">MTDQDQSYRPRSPDFSTFQSVPLSPTFNNHNLNHNAHYQHPHHSPVYQFGNPFAHRASYDASPFFTPQYQPPPLPQQPPSLPHHPVPQTRVPQQSSSYFPPDPDMARRSSRIAQAAEVAPHPPVSKYVDPVDPVDEEDYVPSPPPQPQPQPQPQEEPVAIIEEEEPPKPAPAPVNVEVKTKFPVARIKRIMQADEDVGKVAQVTPIAVSKALELFMISLVTKAAREAKDRNSKRVTASHLKQAVVKDEVLDFLADIIAKVPDQPASRKHDDDNSDQNEQQPKRKRGGRRPKEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIX7</accession>
    <name>A0A370PIX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIX7"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="20573" checksum="E8197ABCBFAB9AD5" modified="2018-11-07" version="1">MSPSLHPLLDNGITKGDPNFPGGNLYCKCSSDKVVVKLASNVAHNHACGCSKCWKPAGSLFSIVGVVPRDAVSVTEHAEKLSIVDASAAIQRYACKSCGVHMFGRIEKDHPFKGLDFVHAELSDQKGWQEPQFAGFVSSIIEQGFHPKGMEEVRSKFHSLGLETYDALSPALMDLIATFTAQRAGVLSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ42</accession>
    <name>A0A370PJ42_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_251264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="58244" checksum="FE1E4474A74E8D5E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJA7</accession>
    <name>A0A370PJA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_15006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="16798" checksum="086D59BC8FBC2143" modified="2018-11-07" version="1">MHTHPLPWHAVYPTPRSAAIGIRREEVLHWFRSGRQAGRDFILVDLRRADFEGGTIRGSINLPAQTLYPMIPTIYSLLSQSPVKEVVWYCGSSKGRGVRAASWFADYIELQGETRLRSLVLEGGIKGWATAGKEYTDLMDEYDASAWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJZ3</accession>
    <name>A0A370PJZ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_300803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="57417" checksum="D48A5D7149135C3F" modified="2018-11-07" version="1">MYTLLLPLLVVICVSVRAIYRIYFHPLSKIPGSKLAAATHLHEFYHDVIRGGKFIWEIEKMHRIYVEGPIVRINPREVHIADSSMYDEIYAGCGRKREKDPCMVSAYASSYAALATVDHDLHRARRAPMNRFFSKKAVIELSGVVQQKVSFLAWHLERVNAEQAVLVLSTAFTALTGDIITHYLYGKDNGYLRERDLVKRNIVWDILAKGTSACHLFRFFPFISTLTKALPIQLMRLVRPELPNVYDMQEQIARQSDKALASERGAKRRTIYHALSDPSVPASERSVARLRDESFIVLLGGTESTAATLTFATYHLLRNKDMYFKLRQELQQVIPEPTSEANWAQLERLPYLTALINEALRLGAAALRPARVAPTETLYYKRYEIPPGTPVSTISYFVHRNPAIFPDPESFNPERWIQAADRRDNLTRYLVPFTRGSRICIGINLAYAELYMTLAAIVRRFDLELCETHPKDMEFTREMVVQRPEKGVWTLKIRVVGINET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKN0</accession>
    <name>A0A370PKN0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKN0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55014" checksum="501875D7EE27C855" modified="2018-11-07" version="1">MPALSVLPADILLHVISFLDHSGDVYSFSLLSPSLFTLVHSNDLVNKTRYRCIRINCTPDLKNAYAILLDILHDCNLASYVRHIEMDLPVRSPLNYKPREYDRPVDAGDMQRLRAAATRAGFIGAEQERLLNMAMQETDYTKDWQYLTYYNTQEDAYHGKSTFIGQALTVLLIASSPNLTSLAISPPFWEYTSSRFNDPSDNHHFAAKIEKYPLAKFLKHANSSHLIEKGEGKIPYLANVKHFQILTTEASSFHIARSRACTPQDLCLCIELVRTLPSIESLRMQAIQGFGNASSAALDGLLPPFSANISRLDLRGCDFKSDLLCKVICSMKCLKELRYSVVQGGCYAGFAEFFDRYSLIDAILRHRATLEVLDLEFDDQLSQFVAVKRESGVQDDAENKSVLKEFMSLRSLSLGVSCLWYIATGMGELRDIVLVDHLPLQLEYLRIRGYEKGHTKALDNMLTGMESARDKHSALCTVQGVNEYIPVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKR7</accession>
    <name>A0A370PKR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_318947</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="192"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="50707" checksum="EAF4906ED1369F0E" modified="2018-11-07" version="1">MDRRVTIASQVAIAAVAGYCIYKAFNARQQQKSLKDAVPKSSAAPLTPEQIKIIKATVPVLQEYGTKITTAFYKNMLTAHPELNAVFNTANQVNGHQARALAGALFAYASHIDDLGALGPAVELICNKHASLYIQADEYKIVGKYLLEAMKEVLGDACTDDILDAWGAAYWALANIMINREAALYKQSQGWTNWRQFRISKKVPESDEITSFYLEPVDGKPLPPFRPGQYISVSVQVPELKYPQARQYSLSDTPRSDYYRISVKKETGLDPRAPGAKRHPGYVSNVLHDIIKEGDLIDVSHPYGDFFLSTAEATHPIVLLSAGVGMTPMVSILNTITKKKQRKIHFIHGSRTTDARAFKNHVQKLENEIPNTQVTYFLSRPGDSDQLGVDYHHAGRIDLQKLDGPSHLYLDNPSTEYYICGPDTFMTQMEEALKAYGVSDNRIKMELFGTGGVPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL49</accession>
    <name>A0A370PL49_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_163760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27561" checksum="F335B1D331B82010" modified="2018-11-07" version="1">METNKHQKDLDRLARIRENQRNSRARKQQHTRELEQKLTALQEQARRKDVDHRMAVQKLEAENRKLKYLLTRSGLTSELIEHYLQIDEPALTEKVAIPKLRSTKTPCKSQANPVCLPKARNAATSALQSNELGIPSPGQSCDLATMPSSETVPPGAPDLEVPVRDQSVCGCGPGEAVESWPSNGDVLNTTLCAIADELINQYNTRGVELSEIRRKLWAGFSKGLTTEEGCRVQNHILFQVLDEISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLD8</accession>
    <name>A0A370PLD8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_214290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="54520" checksum="5913C53AF7FD7EFE" modified="2018-11-07" version="1">MAQVELGDQETSLSTGTEEHERQNDYEVCWEEDDPANPHAMASKRKWVIVSLVCTMTVCVCVTSSLYTTTYNQIMAEFHCSRTVATLGLSFYIAGLGWGPLVMSPLSEFYGRRPIYLVSLPLYVVFLIPCAAAHNIQTMLVARFLDGLAGAAFTSVAGATVGDMYIKSTLHTPMLLYTASPFTGASIGPILGGLINTWALWRWSFYFLLIWSSIQSILVIIFVPETYAPVLLRNRARKLRQETGDDRWIAAIEKLERSVFKTVLHSLYRPFMLLFLEPMCLNLCLLSSIALGVQYLFFGAFGVVYGNAYNFGSWQSGLAFTGLLVGMIMAVLIDPWCCKLYPYFSRGHKEEGNNGSNEPETRLPPAVIGAPLMTIGLFWFGWTALPSVHWIVPIIGSAVFGAGMIFVFQGVFTFFVDAYPLYAASAFGANSFTRSTFAAAFPLFGVAMYHKLGDQWATSLLAFLSLSMAPFPYIFFRYGKRIRSRSRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLL3</accession>
    <name>A0A370PLL3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_326792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLL3"/>
    <dbReference type="SMR" id="A0A370PLL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="137" mass="14981" checksum="950572AF92BB21C6" modified="2018-11-07" version="1">MFRSAVVRSLRASVPRAVKTPAPFQIRSSPVARPAQFAPRFAYQGVRLYSAPAGLNKDEVEGRIVNLLKNFDKVSDASKINGASHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKEADSIHSVDKAVEYILGQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLP2</accession>
    <name>A0A370PLP2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_167118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLP2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="55844" checksum="442E418C3F07B9BC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT1</accession>
    <name>A0A370PLT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_314269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="373"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="644"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="949"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1552" mass="175336" checksum="45A8F880C02CD0D4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLW1</accession>
    <name>A0A370PLW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_282989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="3 4">ATCC 13157</strain>
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            <end position="554"/>
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            <end position="609"/>
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            <end position="641"/>
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            <dbReference type="PROSITE" id="PS50076"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PME5</accession>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
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    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="55"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="8492" checksum="7025E97BC62A3453" modified="2018-11-07" version="1">MAPGAESSKSQKGNPRIEDDSQTTNKEKSVHNVYKEEPQSSSTPGSGSGSRQQTPNSPVASTLKNFDYLQGRPSVLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="638" mass="68350" checksum="A4B3D44CEF3C4C88" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW0</accession>
    <name>A0A370PMW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_314740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="220"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="53772" checksum="CB4B502319811E9F" modified="2018-11-07" version="1">MPPFIPPSEDFPSILKGKRILLTTESLGPVNGVSRTTGKLIEYLRRNGVELAVVAPQFTSSPSQQQDTIDTTIRLPGYPLPYNPDLTLVYPYNLTTTIYPQTFSPDLIYIASPASLGFQLLLQLRQLHSPPPTLLNYQTDLSSYSSIIFPKPLSTFAVWLLSLVEGYLFRTPCIHTIFYPCSDVLSYLKSTNTPMHKTHRLGRGVDTSLFNSSRRSQSLRDTLAPNGEAILLTVCRIAPEKGFEFLAEAVTHLLSSTKFPFKLVIVGGNANPAVTARIQSLFHHISSHIIFLGFQSGEELASIYASADIFLHCSITETFGLVVLEAMASGLPVIARDQGGPSDIVRNQETGYLVSVGEGEVGVFSGLVGEVLRDGRLRGRLGKGARLFAEDMTWERINRRVVGRMADAIVERGNGEVDEERALLGGNRGEVSFGERVRLGGAVAVVYLMWMVAVVPLIVHGSRIVPRMVRRVPLLGRWVGRSSSVAAVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN32</accession>
    <name>A0A370PN32_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_159286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="408" mass="46159" checksum="AE6EB0CC6A6AA295" modified="2018-11-07" version="1">MCGRYALGVRMSFIRRRLQDQGLQVDDAPPDEDVRETYNFAPGNSGAVYLADTHMYPSSHQHDEPASQPDTEKETTEGEKGTAEVEETGGEKKSNATKYKLHSMRWGLIPFWTKRNPDYGSIMRTINCRDDSLIEDRGLWTSMKRRKRCVVVCQGFYEWLKKGPGGKEKVPHFVKRKDGDLMYFAGLWDSVKYEDSDDFLYTYTIITTSSNSYLKFLHDRMPVILDPNSEQMKTWLDPSRTEWSKELQSILKPYEGELECYPVPKEVGKVGNNSPDFIVPVSSKENKSNIANFFANAKKGAAVKVEEGVKDERPTKDAEWSEDNAPKPASGVKREHSPDVETEDTKLQKTEPSVASSPKKSPEKSSPSKPETPAGKKMRSATHNKPMKKSPQKQPPAGTQRITNFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNB8</accession>
    <name>A0A370PNB8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_313541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNB8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="777" mass="89268" checksum="0458605E4B859F95" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE5</accession>
    <name>A0A370PNE5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome assembly protein Noc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="789" mass="89332" checksum="BE03CB7E1B349318" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNL1</accession>
    <name>A0A370PNL1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_313676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNL1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="869" mass="97322" checksum="27A077B610515E03" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ26</accession>
    <name>A0A370PQ26_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_264902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="767"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="851"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1263" mass="143002" checksum="2B1CA61512D7C289" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ83</accession>
    <name>A0A370PQ83_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_248374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="314"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="549" mass="62192" checksum="77B4E6E16F2827E1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQU0</accession>
    <name>A0A370PQU0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_325505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQU0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="420" mass="46514" checksum="CF413F6E003993F5" modified="2018-11-07" version="1">MPATKKAIIIGAGPAGLAAALQLHRNNNIAITVYELRPEPTTLGGAIGLFPNGMRLVHRLGLHEEVVARGFSVTDMEIHSLPNGDIAKVDISGWANRQTGFEYLRIRRKDLQGVLLDAVAKDQIPVHYNKRIVSVSESPTDVTVTFSDGSTDTADILLGCDGLHSSVRRLHVDPSIVPEYSGIAGTQSIIDCTGLPEELSTHANAFLTRTGILAMMPCSPSGDELFWFFSRETPIPHSESGNARDGWEERRQKEVAEYKDTILNIIGEGKGKWPEALTEMVNRTDAVGFYPIFRLPLGGKWYTSRTVLLGDAAHAMQPHAGQGVSMALEDVFLLSRLLKDDQRSLEDAFAKYEEIRKPRITEIYNLAAKNGKMRKDVSPWGLRMKEYMAWAAYGLYNRLGLESWGIGQKHLVYDIDEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR06</accession>
    <name>A0A370PR06_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_264512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="434"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="918" mass="98909" checksum="84FBDB09CF1B40CB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR96</accession>
    <name>A0A370PR96_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_126231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR96"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016843511" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="58" mass="6428" checksum="B8437DA91755F0FB" modified="2018-11-07" version="1">MGPARLALILQLALLVLACVDLSGRGSSNSRRRLMCTTMLEYYSQCQAILTFSHLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB9</accession>
    <name>A0A370PRB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_313274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="547" mass="59931" checksum="621D6F0C1A95813A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSG3</accession>
    <name>A0A370PSG3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_247896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSG3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="25724" checksum="0F9918DB7CCDE2E9" modified="2018-11-07" version="1">MKAALIIVDMQEDFCPPNGSLAVQEARALAPTINTLLSNPGFALRIASQDSHPPNHISFAPNHPPPNNLPFEHFIDMRNPAAGKETETKPQRLWPVHCVEGTKGAEIIPEIDTKNIDLYVRKGMDARVEMYSAFADAFGNLDAEVNRSSVDVHLKGALEENGITDVFCVGVAGDYCVKFTAIDAARAGLRSYFVEDAVRCVDPGEGWEEAKRELREAGVVVVRSDGPEIRGLVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT21</accession>
    <name>A0A370PT21_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_291331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753103" description="UDENN FLCN/SMCR8-type domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="3">
        <location>
            <begin position="211"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="52596" checksum="92740E4A6C417EF8" modified="2018-11-07" version="1">MSHRGHAFGLLCAGLGLFFLPRTAQCAHNDRLSLTHFCEVHGPTSIICSQVLPFPCSQCYPDKSDSSPDETPATSHDTVSSHGLQSRANTKSTPNKLSEKNIDSSDRSPRIEDHPYFLKGQATPADTQQRPNFLGGADGDTCASCSLTLPEDVSKQLPPGAPGTARSDGKGRNGSPVLRSREVVYSCGTSHADHDDTTHDPHAHASYPDSLHSASVTSDASCHTHILTYLSLRGPPNPADYALLRRSSIRTLSCELLPRGLSSGPLCFGDSTAGYTIAYIFRLPDPMARGKRRSYALVALAGKDAGRAFRACPVIWRAFGRIATGIVNSAEKYQEEEKRRDEQNNASNRRGSKQYTPVSSFLTGRALDPDGQLRRPGQVRARNLSEIVGNQYIFAEIHAHFVALLQQLGTMFGASPISEERFVCSTVREEDATASRKSSLVPGGKEKPQDKLSRQYEDSDLGMSTLDISSGPKPIPIAPRRPVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT64</accession>
    <name>A0A370PT64_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_229449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="8710" checksum="E063E4BE4E40DE02" modified="2018-11-07" version="1">MLIKVRTLTGKEIELDIEPDYKVSRIKERVEEKEGIPPVQQRLIFGGKQMADDKTASEYNLEGGATLHLVLALRGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU40</accession>
    <name>A0A370PU40_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_290498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12652" checksum="A0693966EF92A3D8" modified="2018-11-07" version="1">MNQSATAAPWAQGAEKYRGKHCFPLAIDYFAHQEPERIFACIPISSDVADGFRNVTEQDMAAAVLAYIGPSDLRCAILLMAAIMCGTKILFMSPRNTLEQNNALLEIAKVDLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUB3</accession>
    <name>A0A370PUB3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_333499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="55007" checksum="D0AAD3A9794202D9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUC6</accession>
    <name>A0A370PUC6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 allantoate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_324608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72231" checksum="1B067607DA934CCC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUI2</accession>
    <name>A0A370PUI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1688-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="47678" checksum="FD2EC8909569E24A" modified="2018-11-07" version="1">MDSSTRHLLRLEAVRERANIVFRLAEQGKLHHYDYHPERLDATVDYVAGIIQRDFGPDRYDQIPPHGRWQHFDVGGVPRIQKLIERWDASGYDDKEKVRSLLDLFFVSVLLDAGAGDTWRYVEKETGAMFNRSEGIAVASLYMFLNGDFANKNSERKDVVHGEALRTLSVDKLLRGFQVDDSSNPLLGASARVQILQKLGESLRNLPEIFGPSGRPGQIADYLLATSKGSLDYSVLWDVLQKTLIPIWPSDRTRVNGYPIGDAWPLAVLAEHSPSSPTDGIQPFHKLTQWLAYSLKVPFERLLSLKWQNADLGTGLPEYRNGGLFIDMGVLTLKPEAQERGLRTSGGSLPCFAVGDGEIVEWRAMTVALLDKLHERILQSGKFGDIQLSLPQMLEAGSWKAGRELAAKNRPETKSSPILNSGDGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUY7</accession>
    <name>A0A370PUY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_332650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="42480" checksum="6F1D8E49ED61BE1B" modified="2018-11-07" version="1">MLDFEDDASKREKCYTTIGQLPAFIDPKQPPTKRSPCSAILGHPFVHTVEVILPKDIFSHVQPQLQKLRYARVFMSLSSLLEGEFFNTYIKTGNILMISEGHSGSDSVFTLKDGILKLELSKEIFERTGLTGKPVRSGGRKHAKERFIVEINLRLPSMLHGKKGFERIVWAFKNVLNQSVAWLFFDLTTSSGGVSEDDPSLKGNQPQIINCQPILTEHSNILVPPLPGAEITDESRGAAELEDHCNELSEWLAMVSLESPRVSAHDDVDPYLCRYSVPDLDNAKSTSLVSLKWQGLVPSRWIIELLVALLKETAPKSLAPYAWFALSASALGREAVEARDGYTVMVLPAHVPKQDVLGVQADSPSKGNGRHFICWEYVGASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV02</accession>
    <name>A0A370PV02_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endosomal peripheral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_209459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1655"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1731" mass="190908" checksum="AFAD45FF3269D9C9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV26</accession>
    <name>A0A370PV26_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_273159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="250"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="561"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="635" mass="72139" checksum="6B596AAF69610926" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVC5</accession>
    <name>A0A370PVC5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_208937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134648" checksum="191567F77211CCAE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVJ7</accession>
    <name>A0A370PVJ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="70" mass="7668" checksum="4A380BA5346CCFAF" modified="2018-11-07" version="1">MGSPHPSPTLPPLLPLQPPTSYYPNRRKVTLCMQEEKKNHTSLIHGRRTKAERVQAPVSPASAAVSIALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVP1</accession>
    <name>A0A370PVP1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_273364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="438" mass="48439" checksum="E90692CA1C2EB149" modified="2018-11-07" version="1">MPAKSRFTRLDAFAKTVEDARVRTTSGGVITIASLLVILWLVWGEWADYRRVVVMPELVVDKSRGEKMEIHLNVTFPRLPCELLTLDVMDVSGEQQTGVVHGINKVRLTSAAEGGRVIDVKALELHSKDESAKHLDPDYCGECYGATAPAGASKPGCCNTCDEVREAYAQQQWAFGKGENVEQCELEGYAERIDAQRREGCRLEGVLRVNKVVGNFHIAPGRSFTSGNMHVHDLANFFDADLPDAEKHTMTHEIHQLRFGPQLPDELSDRWQWTDHHHTNPLDGTKQETNEPGYNYMYFVKVVSTSYLPLGWDPLFSSSIHSAYDQAPLGSHGIAYGAEGSIETHQYSVTSHKRSLMGGDASDEGHKERLHAANGIPGVFVNYDISPMKVINREARPKTFTGFLTGVCAIIGGTLTVAAALDRGLYEGVSRMKKLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWD2</accession>
    <name>A0A370PWD2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_333062</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000004">
        <property type="entry name" value="Alpha,alpha-trehalose glucohydrolase TreA/Ath1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976891" description="alpha,alpha-trehalase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="13">
        <location>
            <begin position="75"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="12">
        <location>
            <begin position="435"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116183" checksum="A8672482FCFB30FD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWR7</accession>
    <name>A0A370PWR7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_281666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="157"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="617" mass="66010" checksum="A07CC3C4AA48DD4E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYE5</accession>
    <name>A0A370PYE5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_289319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="39738" checksum="13BD125E24F92967" modified="2018-11-07" version="1">MAISPNGARLMVWEIVFAVVTTLMMGLRLWAIRIRRSSIQMHDYFVFIAYLSTCCMEGVCFWAIANGLGAHTDTLTSYEIGVQYQLFISTYVTWTTGTVCCKFSMLALYTSLFPSKRFRYAVWVMYGAVFVYYVFFLSFFMTQCHPISYGWNPVPGGYCKSVMLEEILSIALNMGLDTVIALLPMPLLWKVQMPFRNKLTISVMFAMGLFVVGVMAWRMAITLMPSTQTDFVHGLYLVGLVSFMELWFSMIIVSLPTVAPLFRRYVEPFYKTLTGRSNSNTNPRRLKEAQHTIGSEPGQAKRSKSWQLEDGYLELDDTESGSKGHAEAWSGMSRASLIDASENTPSHAITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYQ8</accession>
    <name>A0A370PYQ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_207878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYQ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000100">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000103">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF2">
        <property type="entry name" value="HISTIDINE KINASE M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="553"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="763"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="959" mass="105563" checksum="D024C04FCF5FD147" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYY0</accession>
    <name>A0A370PYY0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_287881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYY0"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="129" mass="14826" checksum="812ED2368603E962" modified="2018-11-07" version="1">MALPIQENYMPHEEGEPLPLGSIAATLEFAKRQEKARNESRSDWRVLDDDDSNEFRGKVLNVSLTLSTDIKQKLPPEGVRWLYLRTECKKIMNGQMDMQVLIFNERMDLIAISRQVAVLVPAKSKIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZI2</accession>
    <name>A0A370PZI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_299504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017011104" evidence="1">
        <location>
            <begin position="19"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="718"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="817" mass="87956" checksum="A21702498061466D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZR2</accession>
    <name>A0A370PZR2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_331466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF71">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G02650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="59155" checksum="FC9E2B878D9A05AD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZX3</accession>
    <name>A0A370PZX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="73"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="324" mass="36726" checksum="DC0F614DC83E6A57" modified="2018-11-07" version="1">MTSQTPETLSRWSLTGMRLRQHRKLVERHYPLPVGAPPHSKGVISVNAREGQRQIVVYKYCGVEIAGAAPVIIHLSGRGFCVKSHGIDDDFLHCVARDNSTFLVLDVEYRLAPEYPFPAALEDVEDVLRYLRGHPDKYDLTHLAICGFGAGGNLALAMAISSPPDTFETAVVFYPITDMWISEKRKIQLMDPRIRDRMRRGTGGVMPLWVMDTILKCYLRGHPRNIVMDVRVSPGRQQDMTRFPRRCFFITCEGDPWALEARTLATGLMGARRGTPAFTTVRVMEIPGVGHAWDKYRKLDTHGMQLKNMAYNEAARFLRREVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0A5</accession>
    <name>A0A370Q0A5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_7215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0A5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="80"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115687" checksum="5CF683F2A0C59B1E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0M0</accession>
    <name>A0A370Q0M0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0M0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="301" mass="33863" checksum="1E58902C2610B3E6" modified="2018-11-07" version="1">MLSSTPADEKRQRKKLQNRANQRARRLRLKNEQGKGQTARPYSVHRWRVSEYETPSSSTSPTNNHSHTLSQAQNLSQTQTQTDPEPSLTSSSSSSSSSSPSPPSLPTSSTPNISSDHLLHLITHNVFRALYTNKLLLYELSTALIPGPTPQSSIHLIHEGLTFPIYATTIPNSYPSPIPASLFPTPSQRNLIHCSWIDLLPFPRMRENLIKWEACFDHGEFVRDLVGAYVMQEWVLRSGESVEGEIEGRVVVEVEGDGDDEVTGNNRNGWIVWGEPHCKESWEVTPGFLRKWGWVVEGIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1N0</accession>
    <name>A0A370Q1N0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_323194</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1N0"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="374" mass="40601" checksum="F79DFF5A051208B6" modified="2018-11-07" version="1">MSFSNLVSDLAFRDAQDDRSSQISHARSQATARSYTSTAATSVSISGDISSQLHSGYSHPLSRSWQAEKQLTKEMLIYPLFITDNPDEETPIPSLPNQYRRGLNRLVPFLRPLVQKGLRSVILFGVPLHPSAKDALGTAADDPTGPVVQAIRLLRSRFPQLYIVTDVCLCEYTSHGHCGILREDGTLDNAQSVDRISDVALAYAAAGAHCVAPSDMNDGRVRAIKLKLIEAGIAHRVLLMSYSAKFSGCLYGPFRDAAGSCPSFGDRRCYQLPPGGRGLARRAIQRDIGEGADIIMVKPASSYLDIIRDAKELAKDMPVAAYQVSGEYAMIHAGAKAGVFDLKSMAFESTEGILRAGAGIIVSYFVPDFLDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3K2</accession>
    <name>A0A370P3K2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851882">
        <property type="protein sequence ID" value="RDK36443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3K2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56872" checksum="902D4CB97068DF74" modified="2018-11-07" version="1">MSHLAADDWDAINAFMVERIKIPACKGPAGHTGLDGSRWYGMIGAWDIQGFVICEACYLDLVTWNQLRTYFTATPTIKSEERIWTCDAAVPLIKEGLLRAITSRNRWDDLHPIFRRRMQYPSCVEMTKLQASSTHWYASKAVPDLVVCTACYLDHFFLDHASSWELLDLTAEQQQQQLVCAMQTVPIYAAWAGCKRVSMTENTDEYDGFEHLARLILESHPCSTDDMRNATWYAPENCTFDAFAICRRCLLAFMVIPDFAKGFKEFNFRRDGKWLCDFNPASPRFSKYLPKYEDAVNQGNFSIFSKYVSEHGPLPDCPRDQAYKNRKWFGKGLFTACELCYKDVIHGTSLASYLDCAVVPNEARCQMYSRRMRTLWQQACENNDLDSFLVLAKERMDAFLLMELEKQRQLAEMMMRSQRRNNLLLVSGMNSGTDGIISAMGVDNGTRYGNADIGFNWHTSLGAEGHQQFNQAMGMDVVQASADFAQLSPLIQRWATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3V4</accession>
    <name>A0A370P3V4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_331081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3V4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="213"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41285" checksum="B5220D46C6E54758" modified="2018-11-07" version="1">MAAPQNAPIPEAGKKVMSTVTLAPALGFVPIAVHFDLFGCLQEIGKPATAQDVCSFHHTKYGDTDLSVPLANDTLFLMGGLGFLDLLPDDVYQANAVTRFLVDTPSAQHGAMHFTSEGLLASAFLMRRLMDTKFEYPFQECDTPFQYAHKLMGNDHLAREHVYSVMHETGRLDSFNTFMTGKFGRWGTMPDRVRKLGYDLDGLLQSTAPEKIRVVDIGGGRGELLLEMQATYPHLLKKENLILQEYNADIGVVPEVTEMGWNYKEDASEQPVKGALLYSMAHVLHNLSDIESIKLLTKVARVMAPFSRLLIQEFTKNAASSTTHAAMILMHAGRERTSAEWRDLAAFAGLEITFEAYPPNGECVVEMRKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3W9</accession>
    <name>A0A370P3W9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_340385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3W9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017018212" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="17679" checksum="F637642E3D7508FA" modified="2018-11-07" version="1">MQSLLFILTAVAALVAPGLSWSFPGTFPIVRRESIEPGSPLYECHANCGGVILISQDSDDYCSNSTYKSELSACLKCALTYNIWQYYGDDVKSAAEACGDSATPSASSATGAAATATSASNRSATNTGNMATITSTATRSSSASSATSTSGANTSLGFNALVLMLAAAAGVGALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P491</accession>
    <name>A0A370P491_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_330967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
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        <property type="protein sequence ID" value="RDK36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="586"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1377" mass="153703" checksum="5696FE4DC499D70A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4U2</accession>
    <name>A0A370P4U2_ASPPH</name>
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        <recommendedName>
            <fullName evidence="6">Allergen Asp f 7</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">M752DRAFT_340227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Barwin-like endoglucanases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="28943" checksum="7DA8D6DEF16EDB1A" modified="2018-11-07" version="1">MAPLSKSLALAGTLFAAFGSAAPVEKRSTEVVYQTVTSVVWTTVDVTTTIYGAAPTESAAATPTPESQYQLPGNSQPEQSVSYQPSSSTTSTTTAWGAAWTPEPQSWTTSTSTSEWEPAWTPATTSSSSTSQWEPVWTPSTTTQEPAWTPSTTTTVPAAATSSASSSSGGSSSGYSGSCSSGSPCTGDLTYYVAGLGSCGITSNGNTDMVVALPHGIMQDSDCGKTVKITYNGVTDYGTVWDKCMGCDDVSIDLSEKLFKKFGTESEGRLTGAEWYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Y9</accession>
    <name>A0A370P4Y9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_340142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Y9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22481" checksum="0ADC7BD1679377AC" modified="2018-11-07" version="1">MLSVCSITSCNTLFIITYLTVTMPDFYPALRNRRSNELARLAEEHLQHDLRAEDRDALTTATQKVAWWTTIGSAVGLGLGLYAAFRLRSSRKAFFEVFRAREKPTHVVFAGGRSEPIPDITPLLKPTTLGDFATYFFASAGGFFLGGELGFLGGAGSGSRCITADPDRRQRIETAFRKFRAEVLRKEADELDRGLDVSDQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5B7</accession>
    <name>A0A370P5B7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aguA</name>
        <name evidence="16" type="ORF">M752DRAFT_310474</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5B7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000096">
        <property type="entry name" value="Xylan alpha-1,2-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10 12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486419" description="Alpha-glucuronidase" evidence="10 12">
        <location>
            <begin position="21"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="147"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="470"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="841" mass="93760" checksum="0C697A2E9B7B1505" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5J4</accession>
    <name>A0A370P5J4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMEM14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_242087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5J4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11515" checksum="B906F032881A56D7" modified="2018-11-07" version="1">MAEHPSFTLACLLPVGGIAGYMRTRSAPSLIAGVGLGLSYAYAGYLIKENKDYGTELALGNSVVLLVSGVMRSIKTRARAPIPLALGATGLLASFYYQKKVREFRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5K2</accession>
    <name>A0A370P5K2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_225174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5K2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000228">
        <property type="entry name" value="Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="43"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="762"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="804" mass="90343" checksum="AE8E146C1BE2B91B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P680</accession>
    <name>A0A370P680_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F1F0 ATP synthase assembly protein Atp11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_279640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P680"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="36984" checksum="94DF035F0A1708A6" modified="2018-11-07" version="1">MAYFRSSAFKSLLRTRASSLCPQQRRWAQVHDVRFLATHHDPNQVLDRYRSKLKQKAQAEGHGDIDSLKEAYKEKIEEYRHKATTPLTPEPPKSSPSPSKTGPSPPPPPPTPQARAASSATSTGIRPLDSFIDVEKVRSLPPKEIEAIWRLRFANNSHSVCAAIPVETYQRIVSAARKNPQFVLPLPRTQSEAQTAEENAEAAKGGADIHFLQWGFHPPASPTASSAASANDHTSTIIFTALASYQLHGSYAQPHTTITHYLDLADEKGLVLMNGQVMPDSGVSATDATWLVSCVQRFYDFGGQANGRKGELLQAFTRGDVQNFKVEDLMAEAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6B2</accession>
    <name>A0A370P6B2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_224253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6B2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="8">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="124"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="497" mass="54908" checksum="05B27876854DAC8A" modified="2018-11-07" version="1">MSSATPPYEVTLENVAHVLQHDTRVKLAGVDVDGMLRGKLVSKKKFLSIVADGFGFCSVIFGWDMHDRTYFKELTISNKENGYRDLVAVPDLSSFRRIPWENNVPFFLVSFLDPDTSEPVCACPRGLLKSALGKAEAAGYRAMAGAEYEFYQFRAPGTHSNPERNASATATFLKENPVESLPPLTEGMFGYSLTRPIHNQDYYYGVFDACEQFNCEIEGWHTESGPGVYEAALQFGEAKEMADKAGLFKYVVKSIGTKHGITPTFMAKPREGLPGNSGHMHISLVSSDGKNAFIRDTPDPNPPYPDVAYLSDLGRHFLAGVLTGLPDIMPMFAPTVNSYKRLVENFWAPVTVSWGLEHRAASIRLITPPTASAKATRLEVRVPGADANPHFVLAAVVALGWRGVEKKLEIPVPPLSKGEDMGGASDKGVRLAKSLREATTAFMRKDSVAREVFGDAFVEHFGGTREHEVRLWEEAVTDCDMMILTISREVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6B5</accession>
    <name>A0A370P6B5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_298284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6B5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="29800" checksum="9D4B747C46124300" modified="2018-11-07" version="1">MASAPRGRLQGKNAIITGAAGGIGLETSILFAREGANILMADISAPALEKALAKVKEVVPTAPRVETIKCDVSKESDVQAMVESQDSWGGTDVIFNNAGIMHADDADAVDTPEKIWDMTQNINVKGVWFGCKHAVLSLRRHKKTKGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGFRFNALCPAPLNTPLLQDWLGDDKPKRFRREVHFPTGRFGEAIEQAHAVVFLASDESSFVNGSDFVVDGGMSKAYVTPEGPATVAPQNLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P724</accession>
    <name>A0A370P724_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_308615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P724"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477379" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="56462" checksum="4A8E3A2E07FF2EDC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P771</accession>
    <name>A0A370P771_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_88944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P771"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="484" mass="53134" checksum="F031F2C947D06BC8" modified="2018-11-07" version="1">MAGGKRPDVHPVIDLEKDMVGWDGEDDPTNPRNFPVSQKWFLMILVSTITFISPFASSVFSPGVVYAEEEFDVTSTILGTLSVTGYLIGYVTGPLFFSPLSEMYGRRIVLSAANTFFVAFQIGCALAPNISALIVFRFLTGVGGSACLTTGGGVVADLFVAEQRGIAMAVYTTGILIGPVLGPLLGGFIAQRAGWHWVFWVLVIAGGTLSALVMVFNRETNHVVIIRRKTERLRKELNRPELYSCYEPDGADAKGSYTGTLGKRLIMPFYLLVRSPIVFPVATYLATLYGCLYLLFTTVTDVFKKSYGWSTEISGLAYLGLGVGFISGQIVFALVSDRLITRLKLRNNNVFEPEMRLSITMIFAFFIPVSFFWYGWSAQEKTHWIVPIIGLAPFAFGMVGIYNTLQTYVIDCYPRYAASGTAAMVVTRSLMGALLPLAGPRMYSTLGYGWGNSLLGFVTLGMIPVPMLFYKYGGSVRKSSQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7J8</accession>
    <name>A0A370P7J8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_257558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7J8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="46315" checksum="91E79051449B6702" modified="2018-11-07" version="1">MMAPPEPKLSTTVLVVGAGSTGLALAQGLKKAGIPTIVVEKHDSLDAHNRDWNMGLHWGAGPLQALLPEEQWSRIQSVQVDPNEPTAEQDALNFLNGQSGEAMASIPARLFYRLRRRKLRGLMEPGLDIRYGQKLQDIQCSADGEHATAMFEDGSSISASIIVGADGARSTTRHVLLGPNRGEVRRLPYCATFIQAQYSAERARYLRQFHPLYIAGINPAGYFSFFGLHDATDRERPDTWTFFFYISWHSSLQEQRETAGWSNAQRLEQVKKFAKTYTDPWKSAFEWLPDDQQVWHMGLSDFDPREKSHRWDNRGGRVTLAGDAAHAMTYQRGQGLNHSITDAANLVEAVRRFVSGEATRADAIREYEDEMISRAGSEVGLSTVNTAMLHDWHKVLQSPVMTSGMKRSTEIIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7K8</accession>
    <name>A0A370P7K8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_339114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7K8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="170" mass="19666" checksum="10291A068A652F7D" modified="2018-11-07" version="1">MASPTAPASLWSRKRDLIYFSFFAIHVPIIFLVDAAPILPTALQSNLSHTLRQFYIDTYHDKFFEEPPAPWFYFFILMELFYHVPVSVWALGGLKRDDPLVPVHLLIFGLQAFLTSTVCLVEVWSWADRTVAQKQNISMLYGPYVALGAFMALDMFFRLRTRLLVKSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N4</accession>
    <name>A0A370P7N4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_297577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7N4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="109" mass="12386" checksum="7A91A572C7CF2B27" modified="2018-11-07" version="1">MSLRKEDISITSSLTALGLNSLVSVEIRRWWRQNLGLEISVLQITSLDSVQQLGVLAIDSLREKHLGGEGQVPAAKKYMTFTKMHFSTHNPGSVQRMIYSFRFWYVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7P8</accession>
    <name>A0A370P7P8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall protein DAN4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_339159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7P8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016638421" description="Cell wall protein DAN4" evidence="3">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30743" checksum="925B47BC6BBB5603" modified="2018-11-07" version="1">MQLRYLLALSALSSTVFAHAEPAAGVFSLSPQTEAPVAEPTSIMDNYLKPKRYNRSLNFQKRATTTDDTTTTTDAATTTADSTTSDSTSTTEATTTTTSDTSTTSATTTATTATSTTSSSSSTSSSSSSQSTTSATSTTQSTTTTSTTTSTTTSATSTISAAQKEYNHRGEIAAIVTFSILIFIFVALTFFLCFREKSKVNRLAKKADAGADYSMVPLAEGRPQSEAKFDRASMMFASNSQLNLDQMSRRPTSMAASETLSVPMNRTAPGTPSDEHRANMHDITERVAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P865</accession>
    <name>A0A370P865_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_257142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P865"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="310" mass="34043" checksum="C42CCC02FD3D9F35" modified="2018-11-07" version="1">MSKIITVFGATGQQGGSVIRTILNDPELSKQFKIRGITRDASKPEAQALAKQGVEIKIADMNSKDSIRTALEGSHSVFLVTTPAWGAAGSDAELVHGKNVADVAKELDVQHLIFSSLLNVTETTAGRLKNVPHFDHKAKVEQYIRSLEVPATFVLPGYFMTNYTAVGLLRKGENGVWTVAYPVGKEAKFPLIDIAADMGKYVAASLKNRSETLGAQILVAEDYYTPTRILEEFEQVTGQKTQFVQVDSETYKSFMPGPMGLEMLENHLFIGNPGYFNGRSLNESKDLVAKAGYKLTSWKEFLQQNKASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8B7</accession>
    <name>A0A370P8B7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_78774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8B7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="55" mass="6218" checksum="A707B0738EAE8DEA" modified="2018-11-07" version="1">MSYLLYTHQCSWMARMLLEWYVNSRTITLLCLSFSPSLAAGLLALVGGRYGSLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y2</accession>
    <name>A0A370P9Y2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826798" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50235" checksum="0BCF22566B0A4B7B" modified="2018-11-07" version="1">MFSSKTAAFAGLMALSALSGVAAKYNYAVADPYGLPEPVMIDFDDDGVVGGLYRPNTTGPLSRIGVYVMHAEQDYLNFSACHELPRRGFTTFCANNDASKSGYMTDINFEDMMTNVGQGMSYLRNLTEIDKVVIFGHSGGGAMMTAYQNIAENGVKACNGPERIYPCSDAMADLPAADGLILIDANYGLSTMSLLSLNPAIIDEHSGAKIDQSLNLYNPVNGFSESGANYTQSFKKAFEKGVVARNNRILKHAESRLAAINNGSGIFSDDEPFYIVDSMYVGFNNKFFAQDTRWIHHTTYPWPLLHRNGSITTQIVPSVRVPANFESFADNFEGGAIKTTIKRYLSTLAIRVTDDFEYKVDGFEGIVWNSSQTAPLGNIGGVTVPLLNMGNTGHYEYLNAEKLHLAAGSKDAEIAFVEGAQHTIVTCTECETYPGEYGNTLYTAYNYMAEWLSKEGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA79</accession>
    <name>A0A370PA79_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_59433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1392"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1420"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1042"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1431" mass="155476" checksum="7604A25A02F9945A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAH8</accession>
    <name>A0A370PAH8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_61731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016960971" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="97" mass="10443" checksum="068CD689C68949AD" modified="2018-11-07" version="1">MYSFKVISLLSTLLLAGVGSAKLTTTIGLETDEGSHTVHIPFDDCTQVGQFEVRGVFLSKTCRLFTGVGCTGRNTLLQPGEHTSSEPVYVDSVLCYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAI3</accession>
    <name>A0A370PAI3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="21662" checksum="B2DCDDD32C26BDB1" modified="2018-11-07" version="1">MTTPLSTDDLQSRREADYERFKTAAAYTFLIASPVLIALPPRKLDNLTVLLTSAFCVSANHLTREHTGRSIVDRIEARISRNPIAALSDLPSQRAQEIQAKLKAARDAQIRDGSAVGEELERLKARQAQEKPALEKIWMGGETEGWKERRIREEQKALEEGKGYGDLIKEHIWDVWNWGQKEEGKEPKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAZ6</accession>
    <name>A0A370PAZ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAZ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="65511" checksum="0E2C9CB90CC2F526" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB45</accession>
    <name>A0A370PB45_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="529" mass="56732" checksum="80E02E02D339E7B4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBP6</accession>
    <name>A0A370PBP6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_304724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF222">
        <property type="entry name" value="ADAM FAMILY OF METALLOPROTEASE ADM-A (AFU_ORTHOLOGUE AFUA_6G14420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017075498" evidence="3">
        <location>
            <begin position="23"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="5">
        <location>
            <begin position="192"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="58897" checksum="F0FCA6A3212F1962" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD87</accession>
    <name>A0A370PD87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_278024</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="424"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK40135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="553" mass="61789" checksum="9B07BFEE73C71764" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD91</accession>
    <name>A0A370PD91_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_285271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD91"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:riboflavin biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="DapA-like"/>
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        <property type="entry name" value="GTP_CH_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="402"/>
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    </feature>
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            <begin position="1"/>
            <end position="32"/>
        </location>
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            <begin position="1"/>
            <end position="18"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="786" mass="84730" checksum="6F6EFA0216E3BA61" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE04</accession>
    <name>A0A370PE04_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">M752DRAFT_328447</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <begin position="23"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50365" checksum="1D17A9A70611B14D" modified="2018-11-07" version="1">MSAPTKQFHGLSITGDMPTTRSQPEKEPHTDDSDSSELLRSESEESHAEEGDSAASSSVRGKSGITYDLARLDSDTEARALVGLTSQFKVVSCCTTRTGFDFQFIEQPRVHLGPEGYTCTCSTFSGRPNVACQHIFLHGCFIPQPPPSDILLSSDGRLPNFGRVEQLLDGKLETIADQLSWQYVRSEAEGGMSRQDIVRDILSAFSTVILPEEFRLDLLDDAGQSRTPEQCVVQGDFEATMFRLAVHDDGVYSSLCKAMPIAACAVIFFDKVHQRLRKLLADFDRYCLMAQASNTAGGMDVETVILEIQENVERVRENIIARAPHGMEGAAKTLVTLLEDICGRNKDALEGNESGRVTFHGEDEDQRNLFHQLIGKADETGEFFILDALEHVPAMALHQFVGRLKAILHRIEVDRAPKAYILRLDALIRAAESPIANAGQKRPSSSTSRGYSKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE26</accession>
    <name>A0A370PE26_ASPPH</name>
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        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_237408</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="312"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="67783" checksum="51BC67E747921B9D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ7</accession>
    <name>A0A370PEJ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_295046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36943" checksum="C6E89E723928B895" modified="2018-11-07" version="1">MASAPNPGQTLPRMPVVVPAMVPPSNGAEASTGGASNTDPSPDAWDSEMQLVSSLAKLQKMEAMIHQLRTLLPERLLEPLAPIVNPKAAAGRPVPKSPQMLYEQLAQAARAGVSELQEFQSMWRSPEMKAVWDRIDAQIKENGGVMLQPTGKWERDYDTILADLREEEQTQNEQQQKANEEMERSKIQATEGGWRAIVEGFAQKNVPGVRVLASQSEAAVTVVLVKAGMVFRVEAIAGQDGNGVPDWRVFTRTPGGQTPSKVETAVAQCLNSRPRQWDLLYLLDMISSYSTIKQTPCAKCTKMTDSTATLPTIRKPSSTPQEQGSQTWEAYHQGCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PES3</accession>
    <name>A0A370PES3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_277386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PES3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="563"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="722" mass="77494" checksum="86341AF8FC3518FD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PES5</accession>
    <name>A0A370PES5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_320069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PES5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="51446" checksum="CDBA40333D44F0F2" modified="2018-11-07" version="1">MSILSTSRAFLCHPGRLRPVSLPRILSLNTPQCRRLTQTLRLGDSTPIYYPRPISYAFDPAAPANQSGTTLQAFSFLHSSNLAQTSEYQHSIPLNPQDLKVPWPTSLPCALQSQYWREAEDAASDFLQTLFASNNNPKGDKYLTAVTDAVVSYAINLIPLCDLARIKLLSRTFVLAFLHDDAVDAGNVSDKNVLIPIERNSPTPHKAFDILSEEILAADPINGAILVEDILSWGSTSWNHQQGPTHFKSLDEYIAHGLEDFGATLILRCVEFSITTPCSSSSPTDLQSVSYLKSLCAKHLLLTNDLYSYAKEVASGDAGLNAVRVVQDLMGVSDSSAKMMIRFMLRDLERQMDEEYTRLLTSSSMNVNDVQLKHARAMIIAVAGNMFFSATCDRHYTLQLSMTIPSHTDVTGRDSRQRQIYDNIKNYQILGLSSSCLMYARSDFSMQAKSGIKPQPRQVPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF06</accession>
    <name>A0A370PF06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_303500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="610" mass="66720" checksum="FE441F5CE41ACC70" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF52</accession>
    <name>A0A370PF52_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_236897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="557" mass="62965" checksum="05BF7C9B005BC816" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFD6</accession>
    <name>A0A370PFD6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_277548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08620">
        <property type="entry name" value="PI-PLCXDc_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52649" checksum="1B4EE15B4416DC2C" modified="2018-11-07" version="1">MPSKGITVYSYIGVPGYEVGFAVPQQEVLHDVTHNFTSRQLEIDSSHIQGLGNFTGRFEWTVFRYGERVAGAHNDVSSLTGKIEGGTMVATQDFHPVVTEDAIITYGFYAAGHGEVGLTDRHQCYVTICSRENREWMGSVAPPGSPAAQQPFSRFVLAAPHDNGMNGMTACEAIFQHLDSDMLAAVRRLVPQLEHVNHVPDHFLMKKLPHIVYGLSITQKKTVSTMLAMGARYFEFRPAKLLPMFQKVSALRDTFYFQHACIPGLAFDEFLREQVAFLDENQTEIVTVHIRWDNVVADCQRPTEDEISNLLNEACARAVRGPITWGTRECFEQPIEELRRTGTRLIVVIEADKYDSWTAEAYATLSADPIIDRFESMTTEGQADSDLTILQCQATSQSIKEVLVYSVFSAAAASSCLTSTKGMLDMQTLPWIRENALDRLRAERTIVLMNDFIDGATVDTSIMLSRQRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFV7</accession>
    <name>A0A370PFV7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_294745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="49692" checksum="EFFF115F054B6612" modified="2018-11-07" version="1">MIFAIGCQCSRAVSGRADGDYDDLVYLNRARKLALGDTVIFEHANLQQIQLDFLIALFFLSKRHINRAFTFSSMAFRSAVLLGINLRFMDDRTQYPAKEARIRLWWLIFLLEHLLTAITGRVSGTDESPSATPLPIPFEEESFGRSDVSPLLQESSLRMNRLKPTLLQTDEEARASISWQGSCEPSPSLFIHCIVDLVAIGQNLINKVYIVQGIRDGASQVEQRIRKYDSILDIWLSKVPEAYRFTSIDGDPVDIPGENNTPWRREHISLAMSYYSIRIMLCRLCLTHRRPPLGRQTPDPAVPQSSRPNSRCNFGCRTQLHIMWLATTAPWWCILHYIMQATTAILLHLYSWPSELSEHPAHNVAFDLQIMTCVIKKALRWLHHMAYKYAVSQRAFRQCNSIVRRIAPVLRIDLSGLSDSEDLPSDGDSPHLGGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGK4</accession>
    <name>A0A370PGK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_235514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="562" mass="63742" checksum="91A6E22F2929468D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGQ5</accession>
    <name>A0A370PGQ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_319634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="809"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="987" mass="110413" checksum="1856C2CD2852F63C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGZ8</accession>
    <name>A0A370PGZ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_27182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="29988" checksum="E46E195A31A55293" modified="2018-11-07" version="1">MESTRLVSRLQRIYSRVGIYTSPRSGAQPSSRASLPLPSQRVSFSPPRQAACFSTTKPPACANTDSDRFTSALHQNKDWAAQISKEDPSLFPTLANGQQPEILWIGCSDSRCPETTLLGLKPGDVFVHRNIANVLHAGDLSSSAVIEYAVRYLRVNHVVLCGHTSCGGVAAALGNKQLGILDPWLLPLRQLRAKNLDLLNSLPADQANLKLVELNVLEGVKLLKEKSVVLEAIQERGLQVHGLIYDVGSGVLRELDTDESEEAIKARLTSFKTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH86</accession>
    <name>A0A370PH86_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_302000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="7"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="971"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2470"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2548" mass="278617" checksum="3D428057AE9EF4AA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHB1</accession>
    <name>A0A370PHB1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Beta subunit of fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_235821</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 16" id="KW-0520">NAD</keyword>
    <keyword evidence="5 16" id="KW-0521">NADP</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="18">
        <location>
            <begin position="1689"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="17">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="17">
        <location>
            <position position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2093" mass="232658" checksum="FF34AC5EF5E3CF76" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHI6</accession>
    <name>A0A370PHI6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microcystin LR degradation protein MlrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_28648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microcystin LR degradation protein MlrC N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Microcystin LR degradation protein MlrC C-terminal" evidence="1">
        <location>
            <begin position="305"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="506" mass="55399" checksum="95A458671602C2FF" modified="2018-11-07" version="1">MSPRPVIAIAGLACETSMFTRARTLAPAFHPRRAHEIIEEYPFLQPGTELGDAADWRGALTGHALPGGIVVRESFEDLANEIINRLSDIVASTQLDGLWFDIHGAMCVEGLDDAEYELLRRIRRVIGPDVIVSASMDLHGNVSRDLAHQTDLITCYRMAPHEDETETKERACRNLVDLLARQKEAGLIYRPLKAWIPLPILLPGEQTSTRVEPAKSLYELVPKVESLPGIIDAAIWVGYAWADEPRNCAVVMVTGTCEEAVAAGAERLARKFWEVHAEFHFVGPTGSYGECIDVALKSPKRPFFISDSGDNPTAGGSGDVTWGLTQLLARPEFRKESGPTVIYASLPGPQAIQTIVKAGVGATVTVTAGAEVDYTHAGPLTMTGRVHAIKHGDKDAVVEAVLQVGSVFAILTQLRKPYHHEHDFTDLNLNPRSADLVIVKIGYLEPELFDMAADWLLALTPGGVDQDLERLGHHRISRPMWPFDKVFSTPPDISARMIPPSNELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHK3</accession>
    <name>A0A370PHK3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_327693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHK3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="36015" checksum="1C1EFD759FC00F2A" modified="2018-11-07" version="1">MSRLTVVVIGATGSQGGPVARELLKNPHLYYVRALTRDPTKPAAQELARLGAEVQAFDLNAGIDSLLRAFTGADAVFAMTDFWATRSAQKETIQGRSIVDAAARTSTIRHFIWSSLPDPEKVSGGILRNIHHWKSKSVVADYIQQQYPQLWGKTTVVLFPNYFENCLSHPERYLSQPDAQGVYHMYLPHSPSTAMPNGSIRDTGKLVRVILEAEATYFTKTVAFYSEAISEAEKQAMIGKKYGLQTMYHVISPDEHRKKLESQGLSPEIALDYTEQLLMFEKFGNVCEASEFIQAREIPGLHLQSWAEFLEENDILGSMRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHW4</accession>
    <name>A0A370PHW4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_251992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="251" mass="27612" checksum="4F6AE200A63F2844" modified="2018-11-07" version="1">MASLPAGSCCYQGVKHEGEAKGSFSQLNDFEIYTSSPADKSTENGVLVITDVIGHRFINAQLIADQFAANGYFVMMPDLFDNDAIPLNRPEGFDLMAWKGGAYHKDKKPHTPEVVDPIIEACIKEMRTKYGCKKIGAVGYCFGGKYVVRHLRPGQIDAGYTAHPSFVESEELKAIKGPLAIAAAETDAIFPAEKRHESEEILKALGLPYQLNLYSGVAHGFAVRGDPANRTVQYAKENAFLQAVQWFKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIB4</accession>
    <name>A0A370PIB4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_266595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="192" mass="21165" checksum="7C0717CF493E8A77" modified="2018-11-07" version="1">MPEEEPSLNIPSLLTLAVVSFFVLRWFLNRDGGEAGPGSSRSRARGTVDPAQVEQISQMFPQLSAREIMWDLQRNGGSVAATTERILTGRGLEVPPPSFQPQIAIPTTAPVQSQPTQTATSKADAQDLISRYNLRAKLEAENSTAESAPSQASSTTGWSQSKEERQRLLQKRRDEMILAARRKMMQKDQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIM0</accession>
    <name>A0A370PIM0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_284119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="340"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="698"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1170"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1442"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1445"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1517"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1579"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1661" mass="181304" checksum="FAFBD7C026B24510" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIS4</accession>
    <name>A0A370PIS4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIS4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="45198" checksum="B6476FD25408EA26" modified="2018-11-07" version="1">MAVDQSKVLSLVETIKQTALQDQGACQSAQSHFQLLGLIDELRLAVETPTETVLRLIYQPPQNAALRTVMDLGIFPLLVEHSKRGLSATELAAQTGAERGLIVRLMRVMTALGLCANHESEVYTANDKTVALTQPIGRDGIPCIYDLTLPTLAKLPDYFREHRYTSPKEYSRSPMQWAVGKSQFEWLAQHKHRQALFNSYMSSRRHGKPTWFDVYPVERLTNDAMDHRDAAFLVDVGGNQGHDLVKFHDRHPEVPGRLILQDLPKVVSRCPGGRVEGMGYSFLDPQPIKGARAYYFRAIFHDWPDHICRKILVNTISAMDPEYSRIIIVDFVLPDTSAPLLQSSLDIQMMSIGSGVERSERQWRELLDEVGLEITGIWNNNPGMESVIEAVPKQEQRCPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJG4</accession>
    <name>A0A370PJG4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_266152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="22675" checksum="6D598F81B625E466" modified="2018-11-07" version="1">MWNFSFTGRVLDIDGKKLKVWEQLTEFLDFELGQRRVLTRVINMENNLQSLLRICYELDPEDFDFDDSAEAGFAEELAEEHYCHEVQLTAILDDVQDELTDRQLESIRTELAHILETMRQNGYKLVQQHAGYLNYEAQTNKLYLVNLNCLAFSDPNSSTSFPIDEESPYVEAFNIWRAPYNRTLLIADHGLWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJG5</accession>
    <name>A0A370PJG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_319211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="649" mass="73974" checksum="2F81B4597935CAA6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJR8</accession>
    <name>A0A370PJR8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_266237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="137" mass="15929" checksum="1ABAFF24A615707C" modified="2018-11-07" version="1">MFVQEDERALFVGGCRKKNKKNDRDVTRTRNHCHIHYRKAARYHCATRPLLMKMGKSFCNICHNNLYDLWKIEHSMFLTIVVYLLSKSVQIYYGCCAEKCVGSKIQCRHCATASTRCEIVVPFPQRLTLSSPNAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJT4</accession>
    <name>A0A370PJT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sterigmatocystin biosynthesis P450 monooxygenase stcS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_251577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="63108" checksum="92FAD62511F2517C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK08</accession>
    <name>A0A370PK08_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK08"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="525"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="625" mass="67714" checksum="1F5D40CE98F047BE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK79</accession>
    <name>A0A370PK79_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="133" mass="15252" checksum="035470478F526FC4" modified="2018-11-07" version="1">MADAPVTLRTRKFIRNPLLARKQMVVDVLHPNRANVSKDELRDKLADLYKSNKDQVSVFGFRTQYGGGKSTGFALIYDSQEALKKFEPLYRLVRIGAGTKVEKPSRQQRKQRKNRSKKFRGTAKTKGPKKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKD1</accession>
    <name>A0A370PKD1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKD1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744649" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="17586" checksum="A5AFA6444DC8CE20" modified="2018-11-07" version="1">MYISKVLLVTCAAFAPFASAAVQAKPTDTPVPVSSTHVASSPLAPTPTPVSPSPLHTASSSVIISSSSSSSVRFHPSSSASPSHMASSSRRISSSAISSSAIASSSASFTRSYITKASARPTTTTSTDADSKSNSNSGSDSESATAAAASATHSGAAAPAVQLSGGMAAGVLAAAGFIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL75</accession>
    <name>A0A370PL75_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_164075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF82">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="204"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="622" mass="69013" checksum="61FB28B719033262" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL76</accession>
    <name>A0A370PL76_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prefoldin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_214256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="805" mass="88691" checksum="FE3AA66CAFF88C7A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLB7</accession>
    <name>A0A370PLB7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor SipA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_233915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000079">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000349">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="305"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="926"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1392" mass="156241" checksum="FECBA251E10DFD3B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY9</accession>
    <name>A0A370PLY9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI anchored transmidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_275466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY9"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027834227" description="GPI anchored transmidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45221" checksum="36AF22B7C6CDFC21" modified="2018-11-07" version="1">MLTLYSGLLRVLPLLLLAFTITVSSEHTSNWAVLVSTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNADRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRLDEDVPRSKRLGSDAGSNVLVYMTGHGGDQFLKFQDSEEIGAWDLADAFGQMWEKKRYHELLFMIDTCQANTMYTHFYSPNIIATGSSELDQSSYSHHADNDVGVAVIDRWTYYVLEFLETQVTSANSKLTLGDLFDSYDESKIHSQPGVRWDLFPGGEQEGRLRTVADFFGNVQNVEVENINATEPGSLKEDLIEIARLVDKWRARDQDYFVRQNESSVSKDASAHEESSPHYTVRSKVGPAKMSEESTWQKRLVGISVLGACAAVWLTGSILGGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMB3</accession>
    <name>A0A370PMB3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_335155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="940"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131428" checksum="536794A33691D06E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMJ5</accession>
    <name>A0A370PMJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_276217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016909967" evidence="7">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="213"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="43621" checksum="C2F044958B1C8536" modified="2018-11-07" version="1">MKSPISLLAAVGVASAASPQTLLSLASTASDIIDASPFLSFHRDIVQIPSISGNETAVGTFVAEFLESHNFTVIKQPVPSSSNGDPNRFNIFAYPSTSPSQDRPDILLTSHIDTVPPFIPYGLHDDANNNSNILISGRGTVDAKASVAAQIFAVLDTLESNPTASLGLLFVVDEEVGGLGMRTFSDNSTLNPSPSPYHTVIFGEPTEQALVAGHKGMLEFPIIATGQAAHSGYPWLGSSAISALLPALSRVDRLGKIPEAEGGLPASEKYGETTVNIGRVDAGVAANVVPSSAIAEVAIRLAAGTPDEAREIVARAVRNATGGDEHVYCDFAAYAGGYAPQDLDTDVPGFEVTTVNYGTDVPNLKVSEGVKRYLYGPGSIHVAHGDNEAITVGQLEEAVRGYKQLIEAAVQRARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMV1</accession>
    <name>A0A370PMV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="39275" checksum="1364D71F76417ED5" modified="2018-11-07" version="1">MAWPNKNKDMLYRRVGNSGLHVSALGLGGWLTFGGHVDNEITFNCMKQAYDLGINFFDTAESYAGGQSEIVMGQAIKKFGWKRSDLVISTKLNWGLANGEILINNHGLSRKHIVEGTRASLERLQLEYVDIIYAHRPDRLTPMEETVRAFNHVIEKGWAFYWGTSEWSADEISEACGIARALGLIAPIVEQPLYNMLDRQRVEGHFQRLYSRCGIGLTTFSPLKMGLLSGKYNDATTQPPPGSRFAESNDKFASSVRKDWENEQWAGNIKKIVGLKEIADKMGVKLSQLALAWCLKNENVSAVITGASRPEQVVDNVESLKLLPRLTPEIMAEIDEYLQNKPEQDPARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN24</accession>
    <name>A0A370PN24_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="29327" checksum="69DC2573B7AC6365" modified="2018-11-07" version="1">MSISNSALRISRSLMASLNNYPLRQRRFAPLLPSSSSSSSAPPLRGIVFDVDGTLCLPQNHMFSEMRQALNISPKVDILHHISRLPTPESRLEATNKIKAIERTAMESQQPQPGLVELMDFLEERGVKRALCTRNFEAPVLNLLNNHLPAHVFLPIVTRETPGLLPKPDPAGILHIAREWGVQDEGGMAGGLIMVGDSLDDMTAGHTAGAATVLLLNDHNGHLRDHAHTDLCIERLDELIRILDEGFVGHRGGEKVPTSTDNAMENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNL9</accession>
    <name>A0A370PNL9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNL9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="51" mass="5343" checksum="13B8D366EE0CE7A9" modified="2018-11-07" version="1">MGLESQMSIGVGGSDDYQLNLALRPATIDLLVRLFCAVVACLGQSKSAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNR7</accession>
    <name>A0A370PNR7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_145854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNR7"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="204" mass="22937" checksum="A8BF755728AD0BA9" modified="2018-11-07" version="1">MPSRLILRRPSPTTVSFTVSNASRRTSTPAKALFYLQVLLRAVTFLCVLLLDAAKFRRAVFMEDGSWIRWTTIWSSSLGISVCRIADAYSSVVVMLASAVVFYGVFRKGYTEESLLVIRGLGIQTSTSSQTYLSKASTRFIPTTQIQDIVIHEAFKGFEVRFYLAVIVEGESEVVVVFPKLLPNRQILEEVWRGSRSCLYDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNU8</accession>
    <name>A0A370PNU8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_249237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1764"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1792"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1822"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1869"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1881"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1922"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2019"/>
            <end position="2032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2032" mass="229116" checksum="D14C2053916029DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV1</accession>
    <name>A0A370PNV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="428" mass="48077" checksum="E0CA725B4CBC30B5" modified="2018-11-07" version="1">MRTFLRGFFCFRQHSAPAPRLSSPQRRNMVKATSAASTSAALYSLAVVLSPASEGPEDVKEKAHHLKNGFQNPWDSWKSPSVGDALHMWGGIITGKIKFPDVTPPTVPVQQPKFLPDRETSSLRATWLGHACYYVEFPNGLRVLFDPVFEDRCSPFSFMGPKRYTEMPCRIEDIPFIDAVVISHNHYDHLSHPTVKEISRLHPNCHFFAPLGNKAWFSSIGIDKMTELDWWEERDVVLSPSHEPVTEAGAAGESQNSNRSDITARISCLPSQHTSNRGVFDRSKTLWASWGIEAGGRKLWFAGDTGYRHVPELPAGADDHAPEYTFPSCPAFKQIGRFRGPFDLGLIPIGAYSPRWFMSPMHADPDDAVQIFRDTNCKRAMAIHWGTWVLTDEDVLEPPKKLKEALTKYGFPEVGAFDVCDIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPV8</accession>
    <name>A0A370PPV8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="11598" checksum="9F5DEFF9D1414B79" modified="2018-11-07" version="1">MLSRHFTPLLRSHISLTQRASLSTSTARWSQDSSSSAYREGMARYKLFVSPFAKVFLGAIFTYQVIHWTWLKLEMDESKADKNKEVEALEKKAKELTGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ60</accession>
    <name>A0A370PQ60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_137899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="61"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="49964" checksum="DAECFCE3F6899548" modified="2018-11-07" version="1">MRSSEIYPAPPTAADQELWEEKEVSTKQSSLEIGENKDFALHQTQDAFGNEEFAEVKYKVLKWWQCGLLMVAETVSLGVLSLPAAVAGLGLVPSVIILVCLGALATYTGYVIGQFKWRYPHICSMADAGEVLAGRFGRELLGFAQIIFLVFIMASHLLTFTIAMNDLTNHGTCSIVFGVVGLAISFVCTLPRTLEKMSWLSLISFISILSSVFITMIGVGISHPGKVIEATVKTDLIHGFTAVANIVFAFSGHAAFFSLAAELKNPADYPKALMLLQSVDITLYLVAAIVIYCYGGSTVTSPALGSASTVVSKVAYGIALPTIIIAGVINGHVSAKSVYVRIFRGTDHMHKRSWIAVGSWTAIVLALWVLAWIIAEAIPVFNKLLSLVTALFASWFTFGLSAIFWFYMNHGQWFSSPKKVALSAVNLLALGVGCCLCGLGLYVSGKAIHDDPHHASFTCMSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQD1</accession>
    <name>A0A370PQD1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_325383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQD1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="58220" checksum="BD54182E3F1B521D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQD2</accession>
    <name>A0A370PQD2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_264306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="498" mass="56797" checksum="020EBEA4D67B5507" modified="2018-11-07" version="1">MFVYAWLGIGLLAYYVFHSVYLLYFHPLHKIPGPKLAAITYGYEFYYNVIKGGKFVWEIERLHKIYGPVIRINPDEVHINDPDYYEEIYTSRARRREKDPVQIAQFDLDGAVFSSITPETHRQRRSHLDKFFSKQAISNIEYLIHDSLDKIIKTYKEAYQSNNVVNLDAGFAGLTADVIYQYAFGFNPGNLDAEGFNESVRDASNAFFRGIHILNFFPFIKVIMGLMPLGLLRLEREDLYARSVAALERNQTSVQQDEKVSNSRGAILDAIAGPHMPAHMRTPVRLMNEGLALAIAGTETTARSLSVGTYHLLTRDDIRLKLREELKTVMPTPDTRMGRTELEKLPYLSGVINESMRLSTGVSSRMPRVAPTEALVYKEHVIPPGSLFSSSHVFILMDANIFPNPHDFDPERWIRAAEKGERLDRYLVNFSKGSRICLGMQLAYAELFIVIATLMRMFDMELADTPRETIEFARDFGTPYPEKGNLCVKARITGLVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQE3</accession>
    <name>A0A370PQE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_274756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="33682" checksum="B2C5DE36C9B461FB" modified="2018-11-07" version="1">MSQPIDPFAFDPIQLATEPESRGMHRLDDGSEIQRPDVVDDLCQNLLLQARIDRIVHGYEDEGQSPATLVIFGFRFHGLNEERRFKQAIITLTFQDEQKRGGSYDPVVTALWPNGSFTLGEPTIIDMESKKEGEVGADMTAGAVIQGGTHSVVRWEKTKAFQRSDRSTLTGSIFLDPTVRHTGRSNAARLTISENNAAASGIVTDFRVSVLLKRRNDHDTFMASVKLKAKADFRYNLFRGIRRISGFSPPNGPVRFKPGVQYLRPPTLGDEMEARLAEAIEANKLNAARLDKLAGILSTTVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQS0</accession>
    <name>A0A370PQS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_211757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQS0"/>
    <dbReference type="SMR" id="A0A370PQS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="257"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="476" mass="54744" checksum="AF9CF7960FCE4198" modified="2018-11-07" version="1">MSYEERANAHPNLGDESDVEEEALVNDYREQVNFDDGMSELDRTTSLGGGSQTQDLQAQLAAAATPLEYQATLETKFASYDNYCSLFHYILNSDGPVELEVPSYYWAWDVIDEFIYQFESFCRYRNRVARSGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRGEDPLAFAGEYGSRPLYKMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKGGNSYDAIAKKNDQMYALIAICVALHPTRLDDTIHSALREKYGEQLNRLQHGGPEALPLFEELFRSACPKFISPTPPDFENPALNVDPVDHHTAIFMDEVKNTLYNPTIRSYLKLYTTMDLKKLAGFLEVEPEKLRSWLLINKQRSRQVRWVEGGLLEGEPVNANDLDYALENDLIHVSETKAGRRLVDWYLRNLARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQY0</accession>
    <name>A0A370PQY0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_334469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQY0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="38173" checksum="2EC5A0A53D534BBF" modified="2018-11-07" version="1">MADQRVNVHIPSHPPVLDSVRLRNIELPLPAAPDPWHRPGKSQPCTASLKLSYSSAVAAAIADDVSLSLDYGKLYRRLEEDIRNLGKHPENPGHRMISVDGSRRDEMLASDVGQDVRLTAGIVAHCGLGLLDETAAGVRRMSHVHNTQRRSSASAGSQSQALAAIFNSASTSPIDGVFGQCEVSLHLPKALLRAEEGLKYRSVTVWGYRQANEAITDDVGESERCPVVLEEEFRIDGIRCYCILGVNSHERVEKQAVIVSLEFKGPGQLPWGSTVVNSYQAMTRAVAERVETTSFQTVEALATFVARIVTVEFGNERVTVRVEKPSALAFVEGSGVEITRSQAFFEGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRH7</accession>
    <name>A0A370PRH7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_317763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="432" mass="47904" checksum="C629ADF4E11AA782" modified="2018-11-07" version="1">MSSHRKDNIGELIEFARSHSPFYQRVLEHVPAGAKSVTDLPLIDPDEYWRANASNPNGVMTRPLIDGTVMRSGGSTGTPKQVVMTKQELSTHGKVTANAMAHGCGFLPGDRVANMSFHGSLYGSFMLLNTALLELPIPIVHLPISGNESIDMMAHYMKTFEATVLIANVSTTRRLAEYFTSINETLPSLRLILYTGECFTKELRPVYRAAFPNATIYVREYGGIDFGHVGIPAQPFKNEDDDIKPVYKVLAPLVIFEILDENGDPITTSGVKGNVVITSLLKRQQPLLRYPVGDIASWVDYDAETFYVHGRDAVSIKIATTHLPVAYLRELIVRVLGQGKASGSQFIVRLLKETHEQALVLRIVAPEPENTSDLVTAFEEILCEESPTWKKNRKVKNIAPLQIEWIEGKDLITNAGSGKLRDIVDERFSNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRS5</accession>
    <name>A0A370PRS5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulator of differentiation 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_211275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="415"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="506"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="833" mass="88202" checksum="EA2CFD22D45D0CE2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS86</accession>
    <name>A0A370PS86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase D</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Beta-D-glucoside glucohydrolase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cellobiase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_211173</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000021">
        <property type="entry name" value="Probable beta-glucosidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016868185" description="Probable beta-glucosidase D" evidence="20">
        <location>
            <begin position="19"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="21">
        <location>
            <begin position="672"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="756" mass="80836" checksum="4703C8F91CA124FE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSM5</accession>
    <name>A0A370PSM5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_325138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="6"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110987" checksum="5552862E464E5E9C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTB2</accession>
    <name>A0A370PTB2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL Lipase/Acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000019">
        <property type="entry name" value="GDSL Lipase/Acylhydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="29012" checksum="0C1253F248396FC9" modified="2018-11-07" version="1">MSNTVAAAEEEGAYTPYDQFFLFGDSITEYSNAQDMGFGFSAALQNAYARRLDVVNRGLAGYNTLHAIKVFPKCFPTPERANVRLMTIWFGANDASLPGFEQHVPIETYKQNLRNIIQHPLTKAQNPRIMIITPPPINEYQLAGFDAMKGNPHPTRTNAHARKYGQAAREVAAEFGLPVADVWSAFMSTVGWKEGQPLVGSRDLPEDGKFASLFTDGLHLAANGYRIVFEEVMKTIQENWPDQVPEKLPYVFPSWALAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTD3</accession>
    <name>A0A370PTD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 14-3-3 family protein ArtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_291253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="28972" checksum="6ED454A21A9B27E0" modified="2018-11-07" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKVVASADVELTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNESQVSLIKEYRQKIEAELAKICDDILEVLDKHLIPSAQSGESKVFYHKMKGDYHRYLAEFAVGDRRKGAADASLEAYKAATEVAQTDLAPTHPIRLGLALNFSVFYYEILNSPDQACHLAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEPAAEASAPAEKKEEAPAEGEKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTU1</accession>
    <name>A0A370PTU1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_263230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13112" checksum="F07BE5202838A939" modified="2018-11-07" version="1">MKDFNSRDVILHFDASALPMCRNEQIARWALEQVLSSADGGWGNGAGVSCSRSKPEIVRIWNAHSNPKHATLLKQILIVFAHIIPSDDTRSPIMLHHDLHADNIFIRMDMILLSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUG7</accession>
    <name>A0A370PUG7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_311700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUG7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="301" mass="33762" checksum="64FBBB597279F36C" modified="2018-11-07" version="1">MAERVVPVISLNDFERRKDEITQQLVHAAETAGFLTLVDHGITVEEIEQQFAISKSFFDLPSDVKGKTPHSNAQLRPSTGMYDEKESLWLQRGSDWPSDEDVPGFRDTTAHFMAKCATISEQLFICFATALGFPSDYFCVANDVTKPDCLTQLRLIHYPPTVDAAGTWRAGSHTDIGCLTLLFQRDGEDGLEICPGRESHTSFAMGDVFSPLPAKTGQIVVNIGDMLMAWSDDRLKSTFHRVRATDVGESPSRYSIAYFNQGRRDYIMQGPQKKYPPKSVGEWFKESVDRNFAYQKSVIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUK6</accession>
    <name>A0A370PUK6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_312085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUK6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="37882" checksum="D235320C770155C7" modified="2018-11-07" version="1">MQDKANILLIGCGGIGTIAALNLELGGKAIVTAVLRSNYEHVKAHGFSIRSIDHGEVKGFRPSILRNTIPDVEKENLPPYRYIVVTTKNYADVPPTVAEIIRPAVTRGYTRIALVQNGLNIEKPLIAAFPENIILSGVSFCGSHQVSIGEIAHEDDDELYVGAFRNPNLNPDEEDAAAKEYCEIYGAGGKCNPQFNPNVGFSRWRKLLYNACLNTICAVTDLDTGRIQLADGAIENLVRPAMEEIRAGAKACGHDLPPELVDFMITMDPITMYNPPSMQVDIRNGRFCEYENIVGEAIKEGKARGVPMPTLTVLYGLLKAIQWRTKERKGLVKIPEPEDHTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUM4</accession>
    <name>A0A370PUM4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_124678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="30979" checksum="60E036D50952BA8A" modified="2018-11-07" version="1">MSLNIAKWELPGDSPSQQAPALNMPLVLLLAVALLGLLLAVYSHAYVFATLIATQTPNPRLNSPLSRQHFRGLSIFVFHRLSKICVISMFPMKDFSPLKYGFLSLTADLLLSYPRVANVLTILNQHSGTLPYPRCIPTCSVWSKAIASILLQSTASSICFYFPTYLIQLAGALEERIEVSETVQFISLLGTIIVLYFGMVVPAYAIFLRVTASAQRGESMTIRGAWQGFPWSSQVHFFKLLGEVLVLEASVTIVIFVSVLALCHPNLHDGVFQFCVKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW1</accession>
    <name>A0A370PUW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_95833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="431"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="848" mass="95717" checksum="6A33C5B731614446" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVF0</accession>
    <name>A0A370PVF0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_312088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="32458" checksum="9B6CB85B07CEE778" modified="2018-11-07" version="1">MSSTTTTITAKKEEPPQPTESNITGKSAIQAISQGATLPSIPSFTSADKKRRWMLEHMAGAFRVFARKGFSEGMSGHISLRDPEHPDCFWTNPLGLHFGLVKVSDLILLNHAGEPVGGNRSRPANAAGFQIHGVLHKMYPHVNAACHAHSKYGKAWSTFAKPLDMINQDVTMFYGDAQAVYPEFGGVVLEEEESLRLGRHLGDKGKLLILRNHGLLTVGQTVDEAAYLFTLAERSCEIQLQVDAAAAQGLEKKLIEPDAADFTFKMTSDPEALYHEFQPDYEMERALCNDQFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVM7</accession>
    <name>A0A370PVM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_228935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calpain_III"/>
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        <property type="entry name" value="PalB/RIM13"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="calpain_III"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="118"/>
            <end position="441"/>
        </location>
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        <location>
            <position position="200"/>
        </location>
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        <location>
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        </location>
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        <location>
            <position position="388"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="857" mass="95667" checksum="FFB59F704AB93607" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVU6</accession>
    <name>A0A370PVU6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_332921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_eL20_dom"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="21534" checksum="2277571D89EE7C01" modified="2018-11-07" version="1">MKSSQRTDDLHNRRLTEYQVIGRHLPTEANPTPKLYRMRIFAPNTVVAKSRFWYFLTQLRKVKKANGEIVSINVISEKRPTKVKNFGIWLRYDSRSGTHNMYKEFREMSRTEAVEALYQDMAARHRARFGSIHILKVVEIENADSIRRPYIKQLLSKNLKFPLPHRAAHGKKLFAYSRPTTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWP9</accession>
    <name>A0A370PWP9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_324249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="54324" checksum="961B8328E9D7B7EC" modified="2018-11-07" version="1">MSLDHQERTKSEAVLAHPLLYEATTPDVLVDFNGPDDPYRSINWPFRKKAITTILYGMTTCWITFASAIYSAGMQPIAHEFGVSKEVSTLGISLLVFGLGLGPLLWAPLSEVYGRKMVTILPYFIAGIFSFGTATAKDIQTLMITRFFSGFFGSSSVAITGGAMADIWKPEHRGVAIVVYSVTLVGGPCLGPIIGGAFVSNSSLGWRWTEYLTGILMVVQSVLDFLVLDESYAPALLVQKARRLRLEGKNWALHAKHEEWDVSISEMSQKYLIRPFQILNTPIGLFMSIYGSFVYAILYVNLESFPIEFQEKRGWGHVTGGLPFVALLVGIFVAALANVYNNRYYFRKLRENNGKPVPEARLPPMMVGGVAFTGGLFLFAWTSSPHINYWPSLVGIAFTGFGFTTIFQSSINYLVDTFLRFSASAVAATTLLRSILAGAFPLFVQPMFQGIGVNWGITVFGCVAAVLIPVPFLFFAFGKRIRAKSQWSTSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWQ6</accession>
    <name>A0A370PWQ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_104540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="7340" checksum="FAA79EB3E9AF7914" modified="2018-11-07" version="1">MHLKDIQWSILQERRTFSLHRHCSSGLYTGFTYIVILASLSNWYVLLVTCSIFCPSMIMGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWX1</accession>
    <name>A0A370PWX1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_316822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08951">
        <property type="entry name" value="DR_C-13_KR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016986364" evidence="4">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="385" mass="41874" checksum="507C8F4811EA9B35" modified="2018-11-07" version="1">MPGLVLVFPMLPMIVRLLGHIPSADRIDAIYPFGLAVKMSTVSDSTQDRSGVSGLHFRAVSAPRPSNAASTAPGIARQQTHSPVRLYINFCTLIPAAVFIRVRRPPAVTVHHSKLVYSSSSIRKMARILITGSVDGLGLEAARQLVHRGHTVYLHARNQQRAMDAKSACPGAAGVLTADLSSVAETQKLCHDVNAIGNFDAVILNAGLMQGGFRKTPDTGAPALVSVNLISPYVMSCLLRPPKRLIFISSNLHRQANMASMDDMFWFKRGETRYQDYPAYCDSKLHVMLLANAVARRFKNTSVTSVHPGWVATKLGGQGAPDKLEDGVETYVMLAEGDYDEQNLSGAYFEPKRKIGQPIPAARDEDLQEKVVQACEEVTGLRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXH9</accession>
    <name>A0A370PXH9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_289013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49283" checksum="F444A89A2EA88153" modified="2018-11-07" version="1">MDRIRGLIARRPTYEAIEQPVDADDESIRSTREEEQHPRFSKYEYAVFFLLGVSMLWAWNMFLAAAPYFYHRFHTDDWAATHYQPSILTVSTVTNLGSSFILAKLQKGASYPKRVTISLLINIVVFTLLAFSTILMKDVAVSTYFSFLMIMVFGASLATGINQNGVYAYVSGFGREEYTQAIMGGQGVAGVLPCIVQILSVVSVPSKKEGQKAPQESSKSAFAYFITATAVSSFALLAFLSLVKRRASSTLLDPTDDHSDPDVLENKSVSLWTLFKKLRFMASAIFLCFTITMTFPVFTAEIESVHDTPGRSRLFDQAVFVPLAFFFWNAGDLMGRMLVLFPRLSLVNRPFVLFLFSIARAAFIPLYLLCNIRGRGAVVESDFFYLFIVQLLFGISNGYLGSNCMMGAGQWVSPDEREPAGGFMGLMLVGGLTAGSLMSFLVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXS6</accession>
    <name>A0A370PXS6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamide riboside kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_227950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXS6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="38160" checksum="D215C91B80E17742" modified="2018-11-07" version="1">MPPPPERQKTTIIAISGPSSSGKTTLARLLQRIFSKLTPQATNTTTNLRTFIVHEDDFYHPDDKIPLIPHPRDPTTQIQNWDTLSALDIPFLSASLSYIHAHGHLPPRLRSKEDFNDVAESGVSEEVVSRMREVVRGRVPSYFLEDNTNSVSGDGVRTIVFLEGFLLFAPPKEEDPRHGLRDVQEKMDVRLFLPARYDNVKERREGRSGYVTIGPAPVQQGGGGGTELPQRGSVEVDLEEEDDRPPQSFWEDPPGYVDDIVWPNYVQDHAWLLLPEGEEGSTQTAWKDADTQELVRLVGQGVNLRLDTGVTVAPGQGKASMTDILEWAVEEVLKHIAETEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXZ2</accession>
    <name>A0A370PXZ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_63698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXZ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="198" mass="22185" checksum="33C8703809F618E6" modified="2018-11-07" version="1">MGEIRAKDEPCGRPRSSIIPYYKTCCHITSSEVQKTRYVNARINRRKKKKNEAEHLPCFPSTLLDLSNLCPPVQSFTSYFAYHASTFATFIHEGRCSWNVLFLFSVICSVTCPLPHGTLGEEDISPPMSSPVHQTSDHLFRCFNRVWYLSGDCHVGEAGCLPSRCRHPTLDKGLREKAPSVVPFVSSLKPGHGSLPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYL1</accession>
    <name>A0A370PYL1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_272770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYL1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="82" mass="9430" checksum="AE32E06564434A2E" modified="2018-11-07" version="1">MGVPFEALLPFGIIIGSFTVGGAGLWAIRRWDNEGKMPRWNKDKWDRRDLRITGTKRGQSSNPEAPKGFELSNPWKIEKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYZ6</accession>
    <name>A0A370PYZ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYZ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="413" mass="46393" checksum="9EB12103956A0069" modified="2018-11-07" version="1">MPGPDLAPYQDEVKRIGYAISYERQTVLLTGSTGSLGGCILYKLAVQLPTRKIFVLIRGSSELAVKKWKKTMPDHTQAILNSNRVHYIVGDIRKSNFGIEDVMLNRLREEVTLVIHAAARIKLDASISEALENNCLPALELAAMVSRFRRLRLFIQISTAYVNSFLPDGYVGERLYPISDDDPEDELATIQATGHSPYTDCFSSSYTHAKHLMERLTFKRYPTLPVLFVRPTIFGPAVRHPYPLYGPEDSTPLTKFSTLYFSDQGGTQIWHAAEGYTSGRNILDEIPVDFVANACLLHAAAGTQGIVHIGSQLYVSHTFDEILAICRENAPEEIRHELPKIIFVQDRSIPQHILAELVKVGTRNWVFDCGRSYWLKQLGGPLSLAICQLDSERLASARTKEAYEKVLRRMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZG5</accession>
    <name>A0A370PZG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-xylulose reductase</fullName>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_299476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZG5"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="41"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="387" mass="41899" checksum="FBCD7CD986ABF41A" modified="2018-11-07" version="1">MAKRMRPHTERVVRLGSNRGAGCPLSINGGDGETNRSFVLHAIKDVVFEDRPVPALKDPWDVRVHIAQTGICGSDVHYWQRGRIGDFILKSPIVLGHESSGTVVEVGSAVKNVKVGERVAIEPGVPCRHGSYNLCPDTIFAATPPHDGTLSKYYTTQADYCYPLPENMDLEEGALVEPVAVAVQITKVGKVKPNQTVVVFGCGPIGLLCQAVSKAYSAKKVIGVDISQSRADFAHNFGADHVFVPPARPEGKDDTVWNEEVANLMKEKFNLGEGPDVVLEATGAQACIQTGIYLTKRGGTYVQAGMGSENVVFPITTACIRDLHIRGSIRYTASCYPTALDLIASGKIDVKQLITNRFKFEDAEEAFELVRQGKQSVIKVIIQGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZX8</accession>
    <name>A0A370PZX8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_243949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZX8"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="285" mass="31507" checksum="C4148FD24D0FED0A" modified="2018-11-07" version="1">MLYLVGLGLADETDITVRGLEIVKKAERVYLEAYTAILLVDKEKLEAFYGRPVIEADREKVESGSDEILADADKVDVAFLVVGDPFGATTHTDLVLRARELGIESKVIPNASIMSGIGCTGLQLYNFGQTVSMVFFTENWKPSSYYDRVKENVQLGLHTLVLLDIKVKEPSLENMARGRLVYEPPRFMTVAQCASQMLETEEERQEGVWGPDSLAVGAARVGAADQKLVAGTLKELAEVEMGRPLHSLVLIGKRAHDLEKDYIREFAVDQATFDASWQKGGYGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q141</accession>
    <name>A0A370Q141_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Chromodomain helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_206572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="263"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="363"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="461"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="763"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1300"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1357"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1516" mass="172353" checksum="05BB1CA1B97380BF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3F1</accession>
    <name>A0A370P3F1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_260691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3F1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016936654" evidence="2">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="3">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="28381" checksum="C2359E64CCFFD608" modified="2018-11-07" version="1">MMRLARTVYLVLSLLSAALADIEFIDPAAGTVIRAGDEFTAHWRDSGTLPRLASLVQYDLYLCAGGDTVGSHEDIALLAKNALFAKGNSVTFKIDSEVGGNDANAYFLRIAASGPDASVVNYSDRFTLTNMTGSFSPTVINGIPSAMYPTDSFPPAHMDESHEELRKRQVAGPFTIPYQLQTGPTRYAPMAKKPGSTIPVGTPTPQYPTSAYSVATTYLPQATVQMTLSASETYSVISIENTASPAPHAGDTKMKRFLERWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3F8</accession>
    <name>A0A370P3F8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_260701</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3F8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="119"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="397" mass="44905" checksum="5A1899ACE79B7722" modified="2018-11-07" version="1">MASKTLEARLERLSVKDENDSGHNGGSYPKPKSSLSTAMSLSGLGAAGQYSGSNRSNLLKLALQNTNDNKVNAMNVAQSPTKGSQNTLPSRNLDENGEQRHPNPLYDQPAPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGSQDNYYNEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMSVPSFVSPEARDLIKRLLVLDPEKRISLDEIQRHPWILKHCVKDERTMKRSSGSASSKDAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3S9</accession>
    <name>A0A370P3S9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_115408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3S9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="126" mass="14220" checksum="467D004E5DC55F23" modified="2018-11-07" version="1">MKLITVNFLACAVKGCKTAAASYPLHFRDAELELQELEFQPEFILNIIPRIDWEGLRVMANELGFPKIPDTKPEGDALNDEQLLKELHKLLLETQVVEGRLCCGNCGHEYMIKEGIANFLLPSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4A1</accession>
    <name>A0A370P4A1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_242976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="12">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1925"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2024"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1942"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2029"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2067"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2076" mass="230990" checksum="14338DCB65B010B8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P523</accession>
    <name>A0A370P523_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PP2C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_225179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P523"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="139"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="566" mass="60702" checksum="F14E553E04952AEA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P610</accession>
    <name>A0A370P610_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoskeleton assembly control protein Sla2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_279805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P610"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="800"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="302"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118384" checksum="CFD280E660040ADD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6H6</accession>
    <name>A0A370P6H6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_279725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6H6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="72" mass="8286" checksum="D41C22D3D5D6F903" modified="2018-11-07" version="1">MHIAVLSAVERKQGLLINATLVENNIDRPTVLLRKETRLHDQPIPFVEHVDLVISWLGQHSPYVQRACYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6U6</accession>
    <name>A0A370P6U6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_309024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6U6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="56017" checksum="E4C11463B9D942E9" modified="2018-11-07" version="1">MTAPMSATAAARADWRAIAICLFITIAAFQFGFDSSYYSGILVMEPFIKAYGHYDNATGGYVLSSSIQSLTTSIINVGELVGAVSSYLVDDRIGRRGGLFVSSTFVVLGVIFQVSADKLALLIVGRLLLGYAVGLISCLVPLYVADCAPARFRGALVSLYQFDVGLGLLLGVIVDNATKNRNDSGAYRIPMAVQLVFPVILVPGLILFAPESPRWLLKKGKTEQARAALRRLHGNRPDVIESEVLYISGTIEEERRAEGSWRELLHWHQDGRKAYLGMALQAWQQASGINFITSYGIVFFSAIGMTNSFLIQMGLYLVPMPAVWLNQYCVERFGRRPMLLLSCVLVAIVLLIVGGAGTASHKTTTLDRLIVAMVYIYMIVYNLSLGPAVWVVTSEISAGPNRSKLMATSTGVNWFCSWMVTFTFPYLFDSDAANLSARVGFIYGSLMVAAAVWIYFLLPETSGRTLEEIQILFRNGVSAWNFKSYEIPEMPGDSVIDEKKEAHATEVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P704</accession>
    <name>A0A370P704_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_330239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P704"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="585" mass="66219" checksum="CBBBDFF64090369D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P781</accession>
    <name>A0A370P781_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_330282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P781"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="489" mass="52543" checksum="B82254AA2EFFC511" modified="2018-11-07" version="1">MSQSIPQHPGQRENIETRLFINGEFVPSLSGSKFDLYNPATEELSASVYEAGPEDVDRAVAAAKAAFPAWSETGALQRAQLLEKWADRLEACADEMAYLDAICMGKPAYSDNFGRIMPLFVRVYAAKALDITGESSLNTPGFVNVSLRQPFGVCGAIVPWNGPVVTMIFKAAAALVTGNTIVIKSSEKAPLSCLVAARCAQEAGIPPGVFNMLSGFGRPCGEAIARHMEIRKISFTGSTATGRAIQKMAAESNLKSVTLELGGKSPLVIWDDADLSKAVPAAAMSILTNSGQVCVASSRVYVHEAIAPQFLEQLKTTMTEMGKSGHPLNPGTTRGPQADAAQFARVQGYLDLAKQEGVSVYLGGEREGDKGYFVQPTILKDVPEESRLMKEEIFGPVVAVNTFTDEEDVMAHANDSEYGLYASVYTRDISRALRAAKKFEAGTVGVNCTSPTMAFDMPFGGWKGSGEGRELSRYATNYWTELKSVLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7D8</accession>
    <name>A0A370P7D8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_81280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7D8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14903" checksum="CFD689A532E7E675" modified="2018-11-07" version="1">MVDPIGIVGTLMGIVQVCGKLMSVCYEYRMGVRDAPKDISRILDEVVSIGSIAQQLVKVIESDGAPSLPSLQAMGGNDGTLRRCLVELQDLKASLKLGRASSSRRALAWPLPRADVEKRLQVLATIKSTLQLALAADNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7S4</accession>
    <name>A0A370P7S4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_240548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7S4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="250" mass="27301" checksum="54BB3CAFD8DB3F0C" modified="2018-11-07" version="1">MASYLVTGSTRGIGFELVRQLSEKSPSEVSTIIATSRSVNASLQDLADRHPGRVVLVPLDVTVPESIQKAAQTVESIMGDKGLDVLINNAGIVGWGQIKDMADLEDTFRVNVTGPHIITQNFLPVLRKGSMKKIVNISSSVGSIAKQSVYRELPAPSYKITKAALNMMTVLYSQELEIEGFTVFCVSPGWLKTDEANAHADLPVGTGVERVLEMIRDRGVEVNGRFLNIHVPGWENNPGLNQYDGKELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P848</accession>
    <name>A0A370P848_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_257188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P848"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="273" mass="30119" checksum="E6F2595C3AD2139A" modified="2018-11-07" version="1">MESYLKRRTAVITGASMGIGEAIAMTLAEKGMDVALLARSGDKLEAVKARIESKCPDVNVRAYSVDIQSHAEVNAVVKLIVSALGDIEVLINNAGLALGAPGRFWELPIEMVEQMNGTNITGVMYMTHSVLNQSMWPRKRGTIINVSSVTGLECPPFDGEAVYHANKACLEAFTNSLRMETAGSNIRVSVLRPGCVVSHFHLQRVKYDQNAMDEFFYGYEPLVPEDLADAVWYMVSCPERTTIKALDCVPTAQRALTRFDREWNARKDGENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8N9</accession>
    <name>A0A370P8N9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_76200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8N9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31938" checksum="B5896964431EAF24" modified="2018-11-07" version="1">MSDSQVDPDQFTRAGCITQKYYRDVYSTIDPSRPELSQKDRVTIVTGAGKGIGRAIARAHAQSGVKGLVLMTQSAQSAEKTKAVLQAEFPSVEVLALPTDITDEKAVAQTFDTIKNHFGVAHTLINNAGVFSSIAPVAQSDSNTWWKDFEVNVRGTYLVTAAYLRLIASESADFRPTVVNLISTISLTPPGLSSYFISKLAVAKFTEFITAENPRVATYSLSPGIVHTSMTLDSFKPFAKDTAELPGAVTVYLAVKRPQYLNGRHLSSNWDLAELEAKETELSSSDTLKLGQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9C5</accession>
    <name>A0A370P9C5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_306809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9C5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39298" checksum="158528267F9DB009" modified="2018-11-07" version="1">MSTTATITTTTTTTTTAEHPKGQNRMLLDGKPTNYGDFRDALNRDGYAVIKGAIPLDRANGYADAFYSYMEGFNLGFNRNDPSTVRRAKLPVLNEKGMILDYGVTHEQWVWDIRGEEGVVDAFKKVYDDEDLIVSFDVVNVGFANREDLPENKPWPHQDQDPSKPGFRCLQGLVNLLPNGPNDGGLIVCKGGHALSAQFHAEMAHEERIPAWTPEWFGFTDAGMKWLADHGLKWEKVCAEPGDLIVWDSRTPHYNVAPTGGVDRLAVYTCYMPVAEVEKEDLVRKKGAFERRLGTTHWPHAKHVSKTNIAMRDGKPCPVARERPVQEPVLSERVFKLTGIPYLERMEGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9C7</accession>
    <name>A0A370P9C7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_320989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="82"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1716" mass="194183" checksum="0E629681222C2C3A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9C9</accession>
    <name>A0A370P9C9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_306811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9C9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="411" mass="45303" checksum="E3F79FF7A2249D2A" modified="2018-11-07" version="1">MTFNIIIVGGGIAGLAAAIALRSDRHTITVLEQSSQSREIGATISLQPNASKIVEQRWGLADRLREQGSMADSAFEVYNLRGELQTRIPLVTSKYGADRMMYHRVDLHQVLKHRATSDEYPGRAATLRVSSRVKGCNCEDGVVELEDGEILKGDLIIGADGIKSVIRGAVLGREVPGQTTGLSAYRMMVDTDELVAEKGFVDVIDPRVARTTMVVGPDRRLIMGPARNASVYSIVALVPDEKRDEESTSWMTAGDKGKMLATFADFPEWATTPLRLAARKEEDIGLWQLRDLDPLETWCRGRAILIGDAAHAMLPTQGQGGSQAVEDAEALGAFFEGFEGGEAREEVERVCREVFECRYKRASTIQAYSRQAGRPVEEDVRVAMNPAEFMDYNCLYEGAMAWRRQQEAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9N2</accession>
    <name>A0A370P9N2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_307409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9N2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="487" mass="53975" checksum="F30B1E9B8C213CE6" modified="2018-11-07" version="1">MAARDPKSSVGTVQKIADEDNYPHRSLGHVRLRHHETNEVILVPTPSDDPNDPLRWSTSYKIYIAVLVSLAMVMCNFMSAGPTVAMVDVAADFNSSVSRAAYFFNNSALLQGVSNLIWVPLLNKYGRRPIYISAYLLYFFMILGAGLAKTYAGELTTRTILGVGAGAGECLAPVTIADVFYLHQRGYGMAIYNSALSAGVSFGIIISGLVTINHSWRVIYWVGCALVGALWIVVVFFFPETAFRRTDNVDDLYNTQKHAEHVESRGEETLSRKQSYLQSLRFWSGQTYTDESLWRMFIRPFGLILLPPIFWATIVMSVTIGFLVAVTSNFATAFSETYGFAAWQSGLCFIAGMLGCFFGTFAGGPFSDWVADYLTKRNGGIREPEMRLPAILPSVIAAPLALLLYGFGIDRAWHWIVPTIGLGLCRLFTTEIMTIHIANASLQCPLPSVRERMSRSCIVSTPTDRWLEKSPLLSLLLNVGPIFFVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9X4</accession>
    <name>A0A370P9X4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_278814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9X4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="39210" checksum="0F47762143BDC4A3" modified="2018-11-07" version="1">MISIGLESSANKLGVGIMVHPDDGKPPQVLANVRHTYVTPPGEGFLPKDTARHHRAWVVKLVKKALREARISPKDVDCICFTKGPGMGAPLQSAAIAARMLSLLWGKELVGVNHCVGHIEMGRLITGATNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLRISNDPAPGYNIEQLAKKGRKLVDLPYTVKGMDISMSGILAAIDGLAVQYGLDGDWNDDEDVANNASTSDDLENAKPTRADLCFSLQETVYSMLVEITERAMAHVGSKDVLIVGGVGCNERLQEMMGIMARDRGGTIHATDERFCIDNGIMIAQAGLLAYKSGSTTPLKDSTCTQRFRTDDVFVKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y5</accession>
    <name>A0A370P9Y5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_220800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="251"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="47544" checksum="C0A1CB1C3FDD48E0" modified="2018-11-07" version="1">MTNTLHNPSTVDISVASSPSNLDDVPKLLREIKEDVERLSTDSDDIRKDALFKCRKLFQALSTPREIMADHCWGQIGAMMAVGFGVESGLWVLMARNGDKPQKVPDLASSLDIEPKLLSRLLRHLSAMGLLNEVGEDEFQPTNYTKALSLPQIGNGYLGLTACTSGGCLRFHEFSRKRRWTNPTNPEDTSLMYAYGTDKDLFAWVNDLGYGKHLNDYLGGYNLGRRWWTHPDVYPVNERLISGSNPSSDAPFLVDIGGNVGHDLARFRAAYPDAPGKLILQDLPMMIRQIKDLDPAIMRMEYDFREEQPVKGARAYYIHSTLHNWCDDVCEILLKRVKNAMKPGYSRLLINEFVVPETRAHWEITGLDMMMLALFSSEQRTRAAWYDLVERRAGLRIVQVWSAGAGVESVIECEVADNEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAI6</accession>
    <name>A0A370PAI6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore biosynthesis acetylase AceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_239242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000080">
        <property type="entry name" value="Siderophore biosynthesis acetylase AceI, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF6">
        <property type="entry name" value="BIOSYNTHESIS ACETYLASE ACEI, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="446" mass="50731" checksum="8C19D0C06FB3D40B" modified="2018-11-07" version="1">MSPDTTASSQYPLVKLPHPFLTAYRVHTVAEAETSPAKLSLTLHDQPPAGRSPPQPLHLDSLSWLELAPPPSTNCPPPSNNTAWARARRAPRTTFQWTDTTPTLGQIWNVVHAIYLAHPTHEYFSLALSGAGQDVLRTELLATGLGIEHPKATRPDDRAVQPSTDLLILRSSFWQGAASPMGPRPIWVVGEGTDGSLREPLSQYPPMPENYHFTQKFPEEPIYARHPIRRPKPAPGSIAYSRYIPELDEHFSLEVVNWQDPAHLQLFNTWQNDPRVAKGWNETGTLDEHREYLRKLHFDPHVLCLFGRFNETRFSYYELYWSKEDHYGAHYDAHDYDRGRHSLVGDASFRGAKRVNAWYSSCIHYCFLDEPRTVNVVGEPRATGATILSYENAQGLTIGKYVDLGHKRSVHSICSREKWFQLCPIFWDGRERPLESADRAAWNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW2</accession>
    <name>A0A370PAW2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin spn3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_54396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="44894" checksum="CFB53DAA3D2D45E6" modified="2018-11-07" version="1">MSFNALRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKKVLEGKDCDDPANAHIEEGVRIKPVTVGKSPEHGPPAYTPLMRSRKELELDDEGTRISLTIVDTPGFGDQIDNEASFGEIVGYLERQYDDILAEESRIKRNPRFRDNRVHVLLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLIMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDFVEIDGKKVRARQYPWGVVDVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVDGATPTQDSSMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREIAEKRQELLARESQLREIEARMAREASQSQIDSISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBC9</accession>
    <name>A0A370PBC9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_57966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBC9"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="9">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="326" mass="35933" checksum="8C93734652D1A8BD" modified="2018-11-07" version="1">MANPRIMNWDPTQFFRTEEGLPPSPYALLILNHPINERAYDVLRKHALTTVCADGGANHFYEMMKARGREDVDHPTTIIGDLDSIHPDIKSHYQSHGVNVIYHHDDYSTDFTKALRYIRANTSEILSSSAASSTPDHDQANNTHQQYNQDDSLSILILGGLGGRVDQAFSQIHHLYSNSTIPSSSPPSTSSSTEEGRKRGEGALYLVSEESITFILHPGKNVIRTPGVKRGDIPSSSSSSSSDSGGIKEREEGYYLLEENVGIIPLSGMERITTKGFQWDVESWETEIGGQISTSNHIRAEEVEVTAGGAVLFTVELAGRFKRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBI2</accession>
    <name>A0A370PBI2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_328775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="17">
        <location>
            <begin position="80"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="45636" checksum="69CC1040C031165F" modified="2018-11-07" version="1">MSTRRPTMELGTVLVVGGCGFVGWHIVDQLLNFPSETDPSAALPKPQNDPRFIYPKLGDRYPRCIAKVAVVDLRTTHNRLPGAEYYDGDITSEESMLAVFRAVKPDVVIHTATPNVLEGNKPLLRKVNVDGTKVLVEVAGGARGDWGGKCKAFVYTSSSSVVHDTQSDLINVTEEWPLIRGPLQQEYYSETKADAEELVLKYNRASPTSMVTCALRPAGIYGEKDTTFTFKVLEHSAKASPTVLRMQLGENNNLFDFTYVGNIAYAHTLAAYRLLATYSRYESGQGAPLDHERVDGEAFNVTNDSPVYFWDMTRAAWALTGKVVEPHQVWELPEGVLGPIGGIAETVLGLLGKTPRLTRRTVRYSCMTRYYSCDKAKFRLGYRPVVPVYEGLARAVGYVVEQERVAGEKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBU3</accession>
    <name>A0A370PBU3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_51359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662134" description="AA9 family lytic polysaccharide monooxygenase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="340" mass="36358" checksum="08723AE116A8B658" modified="2018-11-07" version="1">MKYLPLVVAATASLAPTASAHYIFSKLVLNGEASADWQYIRETTRSVVYEPTKYTSTFDNLTPNDNDFRCNLGSFSNAAKTEVAEVAAGDTIGMKLFYDTSIAHPGPGQVYMSKAPTGNVQEYEGDGEWFKIWEKTLCDENADLTKDAWCTWGMSQFEFQIPAETPAGEYLVRAEHVGLHGAQANEAEFFYSCAQVKVTGSGTGSPSLTYKIPGLYNDNMTLFNGLNLWVDSAEKIETDILETPIGDDVWSGHGSGSSSAASPSVSSASVASPGTTTAVAHAYVQTPASSSTSSTAASSGNLVSHWGQCGGLNYAGPTECESPCTCVERNPWYHQCVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBU9</accession>
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">ATCC 13157</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="815" mass="90186" checksum="ECC4F4B008F86EF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD37</accession>
    <name>A0A370PD37_ASPPH</name>
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        <submittedName>
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        </submittedName>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40090.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="807" mass="90261" checksum="99586D735255D164" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD56</accession>
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        <submittedName>
            <fullName evidence="4">Cell wall assembly and cell proliferation coordinating protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">M752DRAFT_48946</name>
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    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
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        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
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        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="324"/>
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            <begin position="226"/>
            <end position="249"/>
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    </feature>
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            <begin position="94"/>
            <end position="104"/>
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            <begin position="227"/>
            <end position="248"/>
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            <begin position="415"/>
            <end position="427"/>
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        <location>
            <begin position="453"/>
            <end position="465"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="57745" checksum="9A1C9D5CEC0A5085" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEB5</accession>
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        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 40</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">M752DRAFT_277280</name>
    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="994" mass="109693" checksum="6F37C51449D65027" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEC2</accession>
    <name>A0A370PEC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_337078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Timeless"/>
    </dbReference>
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        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1169" mass="134490" checksum="824CB79E91FE2208" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PED0</accession>
    <name>A0A370PED0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_33840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PED0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="479" mass="52724" checksum="68983ECCF94E7F17" modified="2018-11-07" version="1">MSQDPDSQLSQGPLAPPAEITGPATPMQRASLSASPDLSVGAGIPVSHSDQSKSVSPSLPSSDMTPPPSSQIPGAPRQRSRSTSSSLLASPPDIQKTLCVAYGASENLPTADDIDTADESKLRAMAKDLLSVAQEARMSALHFKLQNSLLSFTSNEAIKRAEVEHQLARREVEIIQSSEYRSRHCQPEVKAVQQISNVELELALKRNQELGRVNATLDRRLRRAKKLIEQEKERSDLLEEENKLLKERIRDNRKHFSQMIEHGPMSPSPQREIQASHRRPVPHYVEHDGRQVNGSDSHDPFAQLLAADRVLNRGSPSVISTPHRSRTYKQHNDGQMRGNHTLPSVPMTPSRARMAPGGNQYSTPGKESHDSHRDRDSTISASDIEEAETEEDIPASEAGALASNMLRSHAFSNRRESRGITNAPKSSTLLQTKLFGQVRKSGVERPSIGLKRKASFDGATSKKMKAEERVGLGIDTWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEU6</accession>
    <name>A0A370PEU6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_36126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEU6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001584">
        <property type="entry name" value="Ras-like GTP-binding protein RYL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="31905" checksum="21F70881CC78EA63" modified="2018-11-07" version="1">MSSSLEAKIVVLGAQGVGKTSLVDRYVKNDFNPSATASTVGASFVTKRVLDSSSDTIVRLQIWDTAGQERFRSISRLYYRGANACLLCYDITDEQSFQEMTGWLAELKKNLVEDDPIVIHVVGTKTDIVTLDPSRRRVPFERTIAYVAEQLYPTQASTPPATAGLGGHSSSSLAGVDSKRSSAFWGQDIGWDCCHEISAKDGEGIEEVFRVITRKLVEQRNKREAGTSSSQRSSTVFDGTTSSLTPGNIDGNGSFRLGYGDKRRSWLGFPPSSVGDELEDIVEGPKRKGGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEV4</accession>
    <name>A0A370PEV4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_36670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEV4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="7137" checksum="43281AFC719D8EAC" modified="2018-11-07" version="1">MHQALSPILQGCCSKRITHQCDTTISQGWKMVAKSRLRSAGAFRYNNIDRPNFRAGCQTRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF73</accession>
    <name>A0A370PF73_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_303590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="17600" checksum="F41A3E5788F7F3F9" modified="2018-11-07" version="1">MSPTPITKSSLIGAWTLVSYIAEPPHPQDDDSPTHYPMGPDARGTLVYTPDGQVTVSVLPKVTKKVWENSNDGVMYAGRYWIEYSNGSECDDDGSERQQPGGVPVVHHEVDMAYSAEFAGSQKREAIISPEGRLRLSGLKLFEVGMREGKDELAAGSQSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFA9</accession>
    <name>A0A370PFA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_277527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFA9"/>
    <dbReference type="SMR" id="A0A370PFA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="197" mass="22250" checksum="ED41386462784E34" modified="2018-11-07" version="1">MFLRSVTRAAARSSAVPTTGLRSYRTVSGPMACLNARPQTEKKSIAPQQTRAASEHAISNPTLAGIEKRWEAMPPQEQAELWMQLRDRMKVDWHQMTLQEKKAAYWISFGPHGPRSVPPKGENLKIFFKVAQLTLVSFGIFYVIHLFAKPQPKTMTKEWQEASNEYAKQEKINPIYGISAEGYEGKGFVQSPPAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFD3</accession>
    <name>A0A370PFD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_39341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="89" mass="9723" checksum="02BBA389435FDF03" modified="2018-11-07" version="1">MNPRFSCPRLIYFASTAAGHESGGLVVVENHGRERVVTPAGRADRQTLITIDFMTVPYGKPSLCAFYGMQLGDEASGIGVDNCEWLRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFM1</accession>
    <name>A0A370PFM1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053161">
        <property type="entry name" value="Ulvan_degrading_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848">
        <property type="entry name" value="DNA-BINDING PROTEIN (PUTATIVE SECRETED PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848:SF2">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17132">
        <property type="entry name" value="Glyco_hydro_106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703464" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="108945" checksum="CF8D8E808AEF2279" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFY7</accession>
    <name>A0A370PFY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_277138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="11984" checksum="3A51A33BFEC703CA" modified="2018-11-07" version="1">MSRHVTLMLRVGPNMTPIAVQEDIPYQDLLAVVGEYVGSGEDAYKQSLTGFSVLWERTTSTSPFPERTLVDQENLQPTLELIALRQGKDILEADRRFEHTSSSGAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG65</accession>
    <name>A0A370PG65_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase C/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_217578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016571822" evidence="8">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="34973" checksum="3C6DEC918126C37A" modified="2018-11-07" version="1">MQAILFLFTFFALASQPVIAWGDVGHRAIAYLAEKYLTNAGSNLVNELLVNDKGFDISDAATWADTIKWKRPLTRPLHYINPDDEPPNSCFVSYPHDCPPKGCIISQMANMTRQINDRHANMTQQKEALMFLIHLFGDLHQPLHVTGVARGGNDIHVCFDGKDHCNNDTKRWNLHSVWDTAIPHKINGIKHNLKHNPERLASAKWADRLHEENKLRPADTECANTQEPLECIMQWATESNQLNCDFVMKKGLQWLEKTDLGGKYYEVAAPIVDDQIFKAAVRLAAWISALAEDREEADNSRGVHLQGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGC7</accession>
    <name>A0A370PGC7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_336993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35485" checksum="9E880D511FDE6D56" modified="2018-11-07" version="1">MQLFHHALMVTAPSIANDDRELQLWQMDIPRIAITHAFVMDGLLAVAALHLAYIHPEQQTHWTSVSLTYQIAATTGFREDLAAGLNDGMEAKFAGSALILILTTAYPVIRSNAVVGQERAEKQGYTLDTVQSIRSALEGCAIMAAHIYQDQDQSSFDCWLRSGRSTPETVHQQRLNKSTETPLLHSELRARLHHLRNEIERGEIESSSRDEFQRVCDINLRILNLWPEHHVTIVWPLWVSKAFLALCRQGNWIAYILLMYYGLTLHLDSHAWFISGAGKQLILDVLSRMGVEGEIPREWAETIRWVRQVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHV3</accession>
    <name>A0A370PHV3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF13">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="32638" checksum="815DD37E525C0E56" modified="2018-11-07" version="1">MSKSGDRFVTETPETRLRTEGGVWTEQEAKEMAEEFPYTWSISNNTITLLTPPTATASTRTAILLPTLQALASHGILRGWRNETFPLYGPDGTIILEIERAASALFGIVTYGVQMLCYTQPRDTNTPLLWIAKRSSLKQTYPGMLDTTAAGGLSTGLPPREAIMREASEEAGIPGDLMRGEMRFVDRISYFHVNMEGGMELLQPEVEYLYELRLEAGVVPRPSDSEVEDFRLWGVQEVKEALGEGRFKPNSAVVVVDFLLRGGLLDGEDGERIRERLHRDLPLPVVDHEAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHZ5</accession>
    <name>A0A370PHZ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_336221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="306"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="531" mass="59238" checksum="85F84583D2EEB175" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI36</accession>
    <name>A0A370PI36_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_327228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017059677" evidence="2">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="228" mass="25310" checksum="DA8BD66B6C8825A6" modified="2018-11-07" version="1">MQFNILCVLTLLVAFVASAAVPEAAPDVTSTYGTWFDVEDFDVTNFKLATRDEEDAIVVAALTLIAAILINARWAPAWGLEGGLKCDTCILVDRGSYLSDLHVTTTATYVRTRQDPLLHWVPQALPRIGCKQGASWEKDHDNGSDRLDEDGSVSFGLPGYAIRESPHSDDENDDGDDVCPIAEVMKDKSSQDFIHEVIILKFTEVIDETMKYIHWALAQLYRTCIPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI38</accession>
    <name>A0A370PI38_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_293851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="188" mass="21047" checksum="1B07B29E450B4266" modified="2018-11-07" version="1">MSIPTSITQILKAGPIHFGPFIVTTQVFHLTPHTYALVNLKPILPGHVLISPRRVVPRVTDLTPTETSDLFLTVRRVARMIERVYGASSLNIAIQDGADAGQSVPHVHAHVIPRKRGDLDDKGGMDAVYEMLDGEEGDLRDVFSKDGDEGRRRRFPRVDNDERKPRSAEEMEGEAWRLAGEMEKELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI55</accession>
    <name>A0A370PI55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_21208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="433" mass="45794" checksum="77327DA01C1E1B5E" modified="2018-11-07" version="1">MPICIECSYPVSHLYSTYSRADDRSLGKGVRLTQCPRCQRFADKYVEHDFVVIFIDLVLIKPQVYRHLLFNRLGGDDNQFDRSIVRLGILLLLFDVYLTWARIEKSPSLATTFLSRAPIIVQYLFFLSLNALATLAHHLTIRLLASILAPTPRGYTGSSQHGNATEAPIFSNPSTPILPSFPSQTNNSQTQLSPTPASTLSPPKLTPQGSSNDVSTVASASGSDIHHLPPTTPQGSFTTLPPPLRRASTAPAQSIRPLPPPSPASPTAISTALLVSSCAKLFPILLVIWGPDGSGNASNVSGSNNTLLSAGSQTTVMQQTLDGSGLAPAATLTTAHPTATGTSSLPGSSSLLESLLRIMPESVPTSYLASFIDLLGPLLSLGAADTHLVLLSNIEALYILLGCGYLRAVALAVAGLAARWTVQRVILGAVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PII2</accession>
    <name>A0A370PII2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_23377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PII2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="91" mass="10009" checksum="E15534E2465A63FA" modified="2018-11-07" version="1">MAVRWAGPEFQKYHVQPVLAGDSPGGTRDHVCAAEGGPLGGVNRYSVWLRVREEVTVATAPAIWRMILAGPWRAAQHDHWAWLLGQLSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ64</accession>
    <name>A0A370PJ64_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_293362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="45"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="473" mass="50320" checksum="53FF422E9213D8E3" modified="2018-11-07" version="1">MAASITARSAASEDEINLSSTMPRLTTMSVTEDHLAQNSTWKSAIIVAASFVIIFTCCGLNFAWGVYQALYESLARKPGTPFNGASPAEIDLIGTISVSLMTIGGPFAVAWAKRFSPRMVSFAGGFVFGLSLILASFGTALWHFELTQGLLNGIGTCLCYMIPVTIAPTWFTHNRGLAMGIILSGTGVGGLVWAPALNACVNALGFRNTLRLTGGLSFALVAIASGAMAWEPASQRRIAIENASRTSRADGILKVPLVDWRVARTRRFMAQALGAIFQAAAYYTPVFFYASYAQSLGYSNTASSNFIALSNACNAVGKIVIGHVADRLGRLNALLLTTCLSAIATVAFWLPSTLTGQTTQSQGLFITFTILYGTFASAYVSLFPTSLVELFGVQNFASVNGVLYMVRGMATMVGTPVGGVLVRSAANALTPKAYENMSVLVSALLFAATAAIVWVRLEAMIGPDGHLLWKWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ87</accession>
    <name>A0A370PJ87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="44064" checksum="7E5E7924A823CA34" modified="2018-11-07" version="1">MPKKQSTSSKMETIAKNDAPASHQSTSGRKENREPRARTRSSSPVRSEKTESTTLLPGVKPVSKIVEQTQDPEKETLTLPEKGPTPQITVEDFNNKYVERSFNFYDLHSTRAIDYEQTYPRRWPEEIQHAFGMALDWARNYAERKHANLSVEQKRDLVSSLDGYCIQNDFDTIVSSLPRSLHNMCLTQLVYLLLVKECISRFFTNPFWYLVPDPERGGDADDKGKLPTNAPVFGAQIFSLYERMRESDPAAAQLWRLWTTRFSHPDHKFGYDMIAHRDSVADRICEEILGQEPVKSLLRSTDKSVLDRARIDLQKFFRSTAELSIDLAEDYGGATKEPCFDGRRILFLEFPAMYLCGDSRDPLYRDVQQKAVVYVQDVVRNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJF6</accession>
    <name>A0A370PJF6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_327369</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="19">
        <location>
            <begin position="556"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="1127"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="878"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="987"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1055"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1115"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1269" mass="136572" checksum="BDFEF7C912A12A5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJG0</accession>
    <name>A0A370PJG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_283729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="140"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="63782" checksum="A21508CF7E622472" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJP0</accession>
    <name>A0A370PJP0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_276309</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJP0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016959663" description="alpha-amylase" evidence="16">
        <location>
            <begin position="30"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="42"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="59"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="61109" checksum="5C1222503B1F9C04" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKI7</accession>
    <name>A0A370PKI7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_250564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF567">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="48"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="468" mass="51270" checksum="3EAD72C2B5C7B6C2" modified="2018-11-07" version="1">MTAPIYRKEKLEQAPTDVAELASDESTSNEIWNALVTEDHQHEIQLRTMSWQKAAWLLAGDQVCLAIMAQSWSLSVLGWVPGIITMVVSGALFWVTSLTMHKYIMKHPQIRNICDFGYYVFGKSQTAYIFSGFMLLANNILLIGFHILTGAKVLDTLSDHSLCTVTFSAIVMVMGIVLSAPRTLRHVSFMSMFSAACMGLAILLFLIFAGIETAPLDFPTDGPVRTYAFPLPGTSWVDCMNAVLNITFLWVPQILFPTFIAEMEHPEDFPKSLAVLAIISTVLFIVPPAIGFRYLGQYATAPAFGSLGLVKYRKASFGFVIVPTLIIGAIYANVTAKFIYSHLLGTSRHAHSNTVVGWGVWALVMIGIWVVGFIFSEVVPSMGDFLSLLGAAFDSFFGFIFFAVAYWHLYRGKLFVGLGRTSMTLLHAFVMACGLFLLGPGLYAAVEAIITDYSGSVSPAFSCASLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKK9</accession>
    <name>A0A370PKK9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_160836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="251" mass="29116" checksum="793049431A7A55AE" modified="2018-11-07" version="1">MTKSQFEVREIHTKEEYARLVDVLWSANFNPYNPVFTAVHPVSGHTAEDRVKDKALDTEIRWAAHEKNPASHLIYVIDTETGRVAGGCEWLIFHKNPFPNGPQPLSCTWYPEGSERAEYASRMLSQAFFPRMCWLQRPHAGVNAMGVHPDYRRRGVGRLLMQWGHERIDPLGYESWIEGSPIGRWLYEESGYKRVISLNIDFAKKNPSDEWNRLVHECQPPAILLLWRPPRGEWNDKVPPGPWAVTEDTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL93</accession>
    <name>A0A370PL93_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL93"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="13267" checksum="74895B578A259193" modified="2018-11-07" version="1">MSDYDKVRIAYDAEKDLNSYQAKQGLGPKSDSTLESGVNEMVDRKFETGIRTGREAGASGSDRKPIPEEEGGIRDDRGRLAKAGQFTGPGGPEDKVKLESERRPGDQDTLGIQDLKREGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN2</accession>
    <name>A0A370PLN2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_276182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000201">
        <property type="entry name" value="Importin beta-3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121203" checksum="83775CB9EC99AF15" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM54</accession>
    <name>A0A370PM54_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein slp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_275528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="336"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="658" mass="71302" checksum="92730C9DE7A41E90" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM99</accession>
    <name>A0A370PM99_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM99"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="406"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="58062" checksum="0DF8EF11BC95B8BE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNM5</accession>
    <name>A0A370PNM5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_334661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="93" mass="10648" checksum="1224A33C7DDF1C7D" modified="2018-11-07" version="1">MTAAESVKSAVGLADNTAASRQEMSDARLPLQYRDSCAGLLIPLNRCRQQEYYLPWKCEDERHSYEKCQYEEFKKRVAKMEELRAAKGGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNZ8</accession>
    <name>A0A370PNZ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">M752DRAFT_213499</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="385"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03372"/>
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        <source>
            <dbReference type="EMBL" id="RDK43644.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="749" mass="84371" checksum="F945EF6913E96711" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPG9</accession>
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        </submittedName>
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        <name evidence="4" type="ORF">M752DRAFT_232457</name>
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    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="294"/>
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            <end position="516"/>
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            <end position="79"/>
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            <dbReference type="EMBL" id="RDK44078.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="564" mass="64826" checksum="8252363C374D77CC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
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                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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            <end position="40"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="74"/>
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        </location>
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            <dbReference type="EMBL" id="RDK44128.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="604" mass="68319" checksum="51AC131793405606" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPQ7</accession>
    <name>A0A370PPQ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_274556</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
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                <person name="Makela M.R."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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            <end position="79"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="16402" checksum="AEC50A326A31848A" modified="2018-11-07" version="1">MASLSRDLAGPSFPDSDLHQSELRTESLKTLQQYTMSPPSGNLIDYDWDQLQEEYIASMEKHENAEKELRNRVTKLLEIFMAWSETTIMRDEIRALKRFKTQMKHVQTSEDDLELKRKHYVDVVKAFESALALLNDRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQD5</accession>
    <name>A0A370PQD5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_325376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQD5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016960316" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="11567" checksum="E0A3427F23758A36" modified="2018-11-07" version="1">MQFTTFLSLAIAAVVPALAADNAAQENIEGSVYPLEFFHGPPTFNDGDASCFTSVTGEIHSVRQAHGITCHIYFDHNCGGDSIPVTVDIPDVIHDHHKPALSARCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQE1</accession>
    <name>A0A370PQE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_313245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016678788" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30196" checksum="C946BBDA6D1DA249" modified="2018-11-07" version="1">MKKNTGTFWALIPSYISLVAASSCYAPDGSQVASSIYQPCVSISGVHSMCCKLNDADPDTCDPSGLCLTSGGAYYREFCTDQSWNSTNCLPKDICGNQNGGNSDWTYQLTNCGDGSWCCGSTTACCNTYETFTLDTTLVKFPSNSDSDLNSNSNSNHNSGSTSGSGSGSNSESDSYASATSAATTGTGTPLGDDSSGISSEQDQSDPDKMKKIAIGVGVGIPLACIAVAMLGAGYVWGRRSMKKEMQPKFQHRILSLPLEKPKGEIGCPRSADDASSVSHCLEMVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQL8</accession>
    <name>A0A370PQL8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_291639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="776" mass="86227" checksum="592B9E35777A138D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQS2</accession>
    <name>A0A370PQS2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58978" checksum="1BAA6CF5C30C95B6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQU2</accession>
    <name>A0A370PQU2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_248254</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="545"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="768"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="1396"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2932" mass="328958" checksum="017439161CEA63E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQZ3</accession>
    <name>A0A370PQZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_231669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23492" checksum="0AEDB4FBF8CAE852" modified="2018-11-07" version="1">MPPRRRAPRAGSRTDLPPLKIVRKILLLQVAYYVTATALILFTTVVYGTPFSLDLVFSWNALRGDTTIGWMLGLVWLLTSGIGVIFLLLLVARSKLIPDFALTLHFLHLIATTLYTHSVPANWLWWGLQGASAAFMTFLGIWACRWRELQPISFGGIGGGSSSGGGISAGASGGGEAQSGAGGEESFSLSRGRGRGRGLRDSSSGGDEYEMVEMKGDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR79</accession>
    <name>A0A370PR79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion mating protein FIG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_143335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="265" mass="28252" checksum="B2A0C81023A93D6E" modified="2018-11-07" version="1">MPGITAKLPRVLQLVGYHHVLMIIIAVAIILLSLLLAGCSSSSPQIPDIFLISMYYERYKPTFNLAQVDPGVVTATANIVGGAEMEVRVGYFGICVQPDAGSYICNSNATALAEIVTVDQDPLNLIWVASTFKDAVVFPYLLILAVILAFFCFVILATFPGWHDELDPSGSEIEARPIPSRPVSQAALALTFVASVFVLVSVLWQHTASVAASTIVQDLGNGSVKSGVGTSAMVLGWFGFGLLVVVTIGLLVMILSVKLIQQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB1</accession>
    <name>A0A370PRB1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_274067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRB1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="30349" checksum="3E45419D3925E0F1" modified="2018-11-07" version="1">MVSSEEAHHVLSSEKGWRENFPDGDLWVFGYGSLIWKPPPHFDQRVPGYINGYVRRFWQDSNDHRGTPENPGRVLTVIDREFWETLDDPLAHHETSATATVWGVAYHIPASHANEVRHYLDIREINGYSDHYTPFHPVLTSKGAESTDTSEYPATPITCMVYIGQPSNPQFLRDPAQREQQAVAEVISRSEGKSGKNAEYLFMLEKALEGLGFGNAEMHVTDLVKRVKALQNEEEVREEEEQAERDLEESLHPSAREAHERFPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRS8</accession>
    <name>A0A370PRS8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_129119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="375" mass="40245" checksum="99DA8A22C425D934" modified="2018-11-07" version="1">MGGLVSCHADEVVARFIVPESPGSSSPILPDIDEKTMAAFPTGKPREEDHLETVICKTCKRPVLKQNAVEHIRGCIRAKQEKARKKKEARDAANRAKEKGDKDGDEDVGAGEKGEGAGDDSMKGQKSAKKSAVKGMAEDGTKKGKKRKTEAGEDDKDKEPKKKKKKEEPKPKVPKPKGPVDVEKQCGVTLPNGAQCARSLTCKSHSMGAKRAVPGRSLPYDMLLQAYQKKNQARQQKAAIDANAPLQDDLDNNGPVDSDEEKDTVMAAISRSHPYPMVTHTLISTKKKYQYVRIKEMLSHALGGSRGGGLFSTGDTLSSPFPDGGSLFTPVEEVSVPEPMAVDEPKPVETQENATDAGAKTPAPEAKKVPVAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRT4</accession>
    <name>A0A370PRT4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_274926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="51682" checksum="2099600465547D0C" modified="2018-11-07" version="1">MADGEPSYIDYEAFLDPEFSPASFANTLVVATNNATDTPLDLSTPLSRVLFDLQEIDTHIHALTTKSALPLLTHTRDQTAAAGRILKEAEEQIASVTQGYERLEREVLRKWEAADEARVAAEKSLATVRLARAVARCLSLGRQLESQLAEIGGLDATAPAKDDYRTLERAASTIVSLRRMFSETAVGEEGHGLDRVKVIRTLRSELVIPAENMVKTRAQQAIGRFTMSTIASAGSGSQSQMSYKQARDARARLVSAVNILYLLSPVPKNVTSAATFQPDLLLSTLQGYMQTAISSSLSNLTRALSMLPTLERTLSDLSARCQDIFALEAILSNLRPPSHPLFPPTAPAAAAGTRNGEQPEPQVQATGKNNLLQPLLNALDTSSLPSYFWRSLASYLAARVQEIINRGGVSARTLRSNRDRIKKEVKDCVLRGSQLPSSILGTEKRLGVDSGLERSWEREAAVMVSSIANVLDRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRV4</accession>
    <name>A0A370PRV4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_230399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRV4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="125" mass="13462" checksum="8C09FA1152C359A2" modified="2018-11-07" version="1">MSETSAAWPLADEALTQNLLDLVQQAGHYRQLKKGANEATKTLNRGTSELVILAADTSPLAILLHIPLLAEDKNTPYVFVPSKLALGRATGVSRPVIAASITTNEASDLQGQIKTIKDKVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS14</accession>
    <name>A0A370PS14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_230472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="588" mass="65932" checksum="D3730A9EEC0FDD43" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS67</accession>
    <name>A0A370PS67_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS67"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="440" mass="50405" checksum="725E61942AB850F5" modified="2018-11-07" version="1">MAVPRPYMPLRRSLCQFSSRTCRTPRNLSAPFRRYSSEQKPPSEPKPFTVWRPYLRLAIGVPFIGALVYSMMTEEVTELDSPSLVELDETLKKQATISEQSPMRLRMEKLIKDHQQKIIEELSRIDGKQFKTDTWSRPNGGGGISCVLQDGNVFEKAGVNVSIVYGELPRPAIEKMRADHKSFVGADVDSLSFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPLNGDKNWWFGGGTDLTPTYLFPEDARHFHQTIKDACDRHDATYYPKFKAWCDKYFYIPHRRECRGVGGIFFDDLDASFLQSSSTSSQNPQETLFSFVSDGLASFLPSYVPIIERRKDMPFTPEQKEWQQLRRGRYVEFNLVYDRGTSFGLRTPNARIESILMSLPRTASWAYMDPVSGTRTEDSVDGDEALLGEGKEREKEIMDVLKHPRQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS77</accession>
    <name>A0A370PS77_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_230608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="794" mass="91045" checksum="E577E4F7281E2174" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PST0</accession>
    <name>A0A370PST0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_264059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PST0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="897" mass="100110" checksum="4585079C6076579D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PST3</accession>
    <name>A0A370PST3_ASPPH</name>
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        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_210505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PST3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="314"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="711" mass="76906" checksum="8DDB311DD7ADA6F4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT86</accession>
    <name>A0A370PT86_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_317510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="445" mass="49799" checksum="78CF8AF9AF370EE4" modified="2018-11-07" version="1" fragment="single">MVDTVVNMEGAAALIRALPSSYALIGLAAIVLYCLYQATMVTDIPRIKGLPEIPGAVPIFGHLRKLGDDHASVCERWWRQYGHSVFQIKLGNTRAVVFNSFEDCRTVLLGHQNAIIDRPKLYTFHGVISSTQGFTIGSSPWDDSCKRKRKAAGTALGRPALRNYHPMFDLESYCIVRDLFRDSKNGQVELNIRPYIQRYALNTTLTLCYGIRMDEVYDDLLREILHVGSAISLLRSASENLQDYIPILRYAPNNEKTARSKELRERRDAYLNLLLNKVRDMIKKGTDKPCISAAILKDEETKLSGVEVSSICLSLVSGGFETIPGTLTSVIGSLSTPEGQIWQDRAYEDIKRYYADPGDAWLSSIHEEKVPYVNAIVKEAGRYYTVSSMSLPRKTATEVNWNGAIIPPKTMILINAQAGNHDVDHFGPDAGKFDPERWLKSVDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTD8</accession>
    <name>A0A370PTD8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_333312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="850"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1136" mass="129014" checksum="9E22C28E3FF24B46" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTU4</accession>
    <name>A0A370PTU4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_120346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTU4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="65"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="252"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="374" mass="42157" checksum="DEF0EB5A3220B95F" modified="2018-11-07" version="1">MYEVMADGSLPAVDFSDGRGSIPDSERKSLTNIHPKGFFIRHPPAPHKLDEDLTPESKLFQTIHMGAAVVDASRWTLIVDGLVERPFSINIEQLRQMPSQTVTSFHECYGSPINPPTKNVWRIGNVQWTGVPLRYLLSIARPDLERGLFVWSDGLDSGTFAGVTTDRYQKDLPIEKALSCEVLVAYEMNGQSLTKERGGPVRLVVPGWFGTNSTKWLGRLSVQTTRSMGPFTTVFYNELDPSDSEGIRRRPVWRVEPNSMIVRPRPDEVVLGPGYVEGWGRAWGEDEISRVEISLDGNTWKEANVALRKQFEWQLFTFRVQVDRSGRYHIQARATDISGAQQPLTGRRNHVPTVQIWVESDSPKKSIPRGNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUE4</accession>
    <name>A0A370PUE4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">flavin prenyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_200573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="186" mass="20222" checksum="988FEE684FE826CD" modified="2018-11-07" version="1" fragment="single">STPPQPNLRHNRLILALTGATGSIYGIRTLTTLHQLNIQTHLILSKWALPTLRYEAPQNTVPYLTSLATHAYSPRDLAAPISSGSYPVDGMIIAPCSMKTLAAIRMGYGEDLISRAADVCIKEGRKLVLMVRETPLSVIHLENMAALARLGVVIFPPVPGFYTRPKGIDELVGHSVARMLDVMGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUL5</accession>
    <name>A0A370PUL5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,6 mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUL5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41147" checksum="7C283B5683CCDA3C" modified="2018-11-07" version="1">MLPSTLKSSRYGRFVILTIPLLVFSCLLFLTWDPLPGRLARQQSTSQSDPLSQVPQAVEPPKEEPSQPKTPVSTSKPSSSKPTADIAGGDAIFGITDKLWQSAKDPHLSDDQDEWISSWLEKNPSFRYELLTDTSAATFVRTHYASRPDIIEVFETLPIPILRADLLRYLLVLAEGGVWSDLDVTCDKPVADWVPTEYKNAKIEMIVGLEFDFEWRGEGTEIASQFCNWVFAAPRSSRVLQVVVDAVVDKLKEIAAMNNVQVKDLTLEMLPIDVVNVTGPKIMTMAILDSLKQLLGRTVDDRDFHGIKKPKLIGDVLIMPGVAFAASQNGYPQDQGDALVTHHYAGSWKQADAEAKEKKKQKQNGRDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUZ3</accession>
    <name>A0A370PUZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_228640</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000247">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="18">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="19">
        <location>
            <begin position="519"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK46008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116143" checksum="A2C3CCDE70D666EF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVU8</accession>
    <name>A0A370PVU8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVU8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="36089" checksum="05F7871F9E2A9995" modified="2018-11-07" version="1">MLSQQQQPQQQQGLHRPSPRVLSTKRLHSHHPDSISSRYRAGKAKPRSREQSVVASRRLHRSRHTPDTPPDGSNSSLSQGVITLTIGPTKRLFAAHKDILCVSPYFAALCNPPNNDVSSSSPSSSPSSSPNPTKSMRQIDLPDEQPEIFSCVLEYLYRGDYYPRLRHDKTTNTWDLETTPSSSTNTRTTTNNKDTTDPNAIIFHPAVGAEILRDTAVYCAAEKYSLEHLKRLALKKQGLHSNIPCHIILSSARYAYMHTPDTESKLRAHYLALIIRSRGTFKRSGTMQMEMERGGKLFFDLFVAMCNHMDDLEEAARGEGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW18</accession>
    <name>A0A370PW18_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="237" mass="26705" checksum="C910B076B66E948A" modified="2018-11-07" version="1">MDLYNTCEGNWEQIATKTGVGIPLLDKFSDYAARFLSNIGNHFKFTPDISGEALNSLASVSSSASKILEQIKPDDIAYNMYLQLGVDGLRGLENYDPTTKIWGQAHSRAHYAIFQHLLRYSGGLYTVTNDVEMNGLTVKVDQSRVISRGKSSLGRMLLKLFIYRCNADVSNCRRFYENLSIVDDEALKWRDILVSKEDPPLVFSQANTYLVGDDVKINEYEPTAQGVVQNWAERSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXB4</accession>
    <name>A0A370PXB4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="43550" checksum="D5B0B370690346B7" modified="2018-11-07" version="1">MTWFTGARDTSDKGWHFDAVSLLAVIGESIIERQKHIIVASSFSVLPRLLPAPQAILNMGSTTQLPLLKNVSVIGVHSGAMYDELGYVAQRIHQTDKLQPYECRVYEICRSESYEPDADIRELEECHESRRIRIRLKQFCVMNILTLASVLLTVGLAVWSILIHDGIGLLAITTMSISSSLACLSQRSNPETGEGRTDLDKMPGDVVIRTKNGAFVVVHCSETIAQELYAKRESYFYARKPESSVFKMLMGTSTILLMVSVLLFSNCGWTMQTAIAVTYILLNLCYWAVPVLFDEKSFWDLSAIYKITLLKHTYKKNLTRALWEAISSTHQVKWVRKSRILPDTEAWKAWLQEAKERLSSNLDWDPEMARDRLMAKVSLPPRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXC9</accession>
    <name>A0A370PXC9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_306154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXC9"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31846" checksum="9BDC5B749BFB1AAA" modified="2018-11-07" version="1">MTQPLNFHIFGGSNIRASLSPTIHNAAFTHHHLPHTYTTAECTSLSEISHLITSPSFGGASITMPHKIAAFDHCTEVSDSARAIGAINTLVTTRSPQANSKVVVKGDNTDWSGLYTLIIDHLSKEGVHAAKPTGKVGLVIGAGGAARAGVYALLQAQFSTIIIWNRTVEKAEKIIQDFDTLKSEGIEMRAVGDVTGIGPVDVVIGTIPGDVKAEEDFEGLFQGSKMGLCVEMAYKPKVTPLMRVAERRGWVVKDGLEVLLRQGFEQYRLWTGLEAPELVMREAIEERDGVRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXJ2</accession>
    <name>A0A370PXJ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_272693</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXJ2"/>
    <dbReference type="SMR" id="A0A370PXJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000037">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016587707" description="alpha-amylase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="29"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="256"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="54676" checksum="658084F3848BBA30" modified="2018-11-07" version="1">MTIFLFLAIFVATALAATPAEWRSQSIYFLLTDRFARTDNSTTASCDLSARQYCGGSWQGIINQLDYIQGMGFTAIWITPVTAQIPQDTGYGQAYHGYWQQDAYALNSHYGTADDLKALASALHSRGMYLMVDVVANHMGHNGTGSSVDYSVYRPFNSQKYFHNLCWISDYNNQTNVEDCWLGDNTVALPDLDTTSTEVKNMWYDWVESLVSNYSVDGLRVDTVKNVQKNFWPGYNNASGVYCIGEVFDGDASYTCPYQEDLDGVLNYPMYYPLLRAFESTNGSISDLYNMINTVKSTCRDSTLLGTFVENHDNPRFANYTSDMSLAKNAATFTILADGIPIIYAGQEQHYSGGNDPYNREATWLSGYKTTSELYTHIAASNKIRTHAIKQDTGYLTYKNYPIYQDTSTLAMRKGYNGTQTITVLSNLGASGSSYTLSLPGTGYTAGQKITEIYTCTNLTVNSNGSVPVPMKSGLPRILYPADKLVNGSSFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXP3</accession>
    <name>A0A370PXP3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXP3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029327">
        <property type="entry name" value="HAUS4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14735">
        <property type="entry name" value="HAUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39277" checksum="AB93848DD7FD39CB" modified="2018-11-07" version="1">MIPPCDPVILENNPQFKRLYTHLTTTLLNPDGSTRAQDAQPARQAVVEEVKACRIRDAKKQIKKQALRRLAFDPDSGLPDDCRDPVAIITLYLESSPDLLKLDDDPSDAATDAQLLLAPDIDEFYSNLPLLATPLSNVLSQTLNDIRTIANAGSSDSSDSGSTSRPNEPPRTTRARNRQAMLRSIAQVSLASQLGDRIRALRQIQLTELPAARTRMAATAAEVLATRAAVLERTVMLLERAKHGAMARAAKAKADHLVAVAQGIEGKLNVTKLEILATIHTPEVVDALRRYYQHLRETRERLEERRAMALDELKSYEDSIDGAGRGPMKELARQYGSLIREVEDVRMEIERLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXQ9</accession>
    <name>A0A370PXQ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_272749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXQ9"/>
    <dbReference type="SMR" id="A0A370PXQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="224" mass="25617" checksum="E7DD5C4E045EEBF0" modified="2018-11-07" version="1">MSNPLDTDAGSELFSSYETELKLVQADLNQKLDQIAESSGEQRKSAIRQAERALDEATELLDQMRMEKQNIPSAARSKINTRVRNYATDIDEAKRKLRSLSDDRKALFGDRYTDDPQDEHLEQRQQLLSGTERLERSSARLQESQRIALETEDIGRNTLADLNQQRETIMNARGRLLESEGYVDTSIKTLRGMARRMATNRLITIAIITVLILLIFAVIYSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXX9</accession>
    <name>A0A370PXX9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_306373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXX9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000002">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="32567" checksum="1B1BD89A186F14FC" modified="2018-11-07" version="1">MAPGGGRDFNCTWEHCNKSFNRKSDLCRHYRIHTNERPYHCTVKDCNKSFIQRSALTVHSRTHTGEKPHVCDHRGCHKAFSDSSSLARHRRIHTGKRPYICQEPTCERAFCRKTTLTKHQHRSHPPGSMTRLPSEDAVSEHSYQGPVAVPVPNEQYLLAQQPYYPHTPTPTHEFYPHQSLHITPVPIQEQPPIVTQHIPVTSPVDVQRAQQHYMQLVQQQQQQQQRYDPGRQGYLPPEFQQPYHALPTADGPPLMVTSTQSDYKPPARILNQPEGTDWGFLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY94</accession>
    <name>A0A370PY94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="331" mass="36917" checksum="53FFB70B6667CF1E" modified="2018-11-07" version="1">MPEIAGKEVGPIGFGLMGLTWRATPPSQEQAFDAMHTAIQKGCTCWNGGENYGPLEYNSLVLLEQYLERYPEDADKIVLNIKGGVNPETHQIDASPENTRRSLDNCIAQLKGRKKIDMFEFARRDPAVPMHETFALIEKEYVQTGKIEGIALSEVRAETIHEAVKYTKVLAVEAELSLFTTDILENGVAAACAQYGIPIIAYSPIGRGMLTGQFKKFDDLPQDSLLRSFDFPRFQRENFEKNMQLVQKIEDIAKRKNCTPAQLAINWTRALSRRPGVPTIIPIPGATTAERVEENSTQIDITDEEMLEIDEVLAKFTPAGERYPGAIPVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYJ1</accession>
    <name>A0A370PYJ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_71821</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="83"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="50144" checksum="71C03B539FA8A634" modified="2018-11-07" version="1">MVMAPTACVPAEVCTPKYYQEKHDYNLNWDHGQFSNHGGDDLSQSRLAAKELVLDILKKRAAEVNVDSCAPGEEDPFYVADMGEVYRQHLRWKMNLSRVRPFYAVKCNPDPEILRLMAKLGNGFDCASKAEIDMALETGVDPSRIIYAQPCKTKSYLRYAAQVGVKQMTFDNADELYKIKANYPDAELYLRILTDDSNSLCQFSMKFGASLDVARQLLELAHQLELKVVGVSFHVGSGAEDPKAFLKAVQDARLVFDQAAEIGHELHTLDVGGGFSQDTFEKFAGVLSEALETYFPPNIRVIAEPGRYYVANAFTLAANIIARREVRDPEDPANDAYMLYLNDGVYGNFSNIIFDHQHPVAQVLTCASAANSPYAATSGGVTYSIWGPTCDGIDVISKRIELPALLEVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGASALLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYJ7</accession>
    <name>A0A370PYJ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="80" mass="9204" checksum="AB5DC2AF059000FE" modified="2018-11-07" version="1">MPQEISDIKQFIEVCRRKDASSARIKRNPKDQQIKFKVRCSRFVYTLVLKDSDKADKLKQSLPPALKVVDVSKGDKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYS8</accession>
    <name>A0A370PYS8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_245677</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYS8"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="202"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="404" mass="43436" checksum="A7CBC13A4E4CF216" modified="2018-11-07" version="1">MAASADSQVFRATTTAPVNIAVIKYWGKRDAVLNLPTNSSLSVTLSQRSLRTLTTASCAPFYPAKDELTLNGKPQDIQSSKRTLACLASLRAHRRELEDANPSLPKLSSFPLRIVSENNFPTAAGLASSAAGFAALVRAVADLYQLPQSPRDLSRIARQGSGSACRSLMGGYVAWRAGSLEDGSDSLAEEVAPQSHWPEMRALILVVSAAKKDVPSTEGMQTTVATSNLFATRASTVVPERMAAIETAIQNRDFPAFAEITMRDSNSFHATCLDSWPPIFYMNDVSRAAVRLVHDINRAIGRTVCAYTYDAGPNAVIYYLEKDTELVAGTVKAILGEKTEGWEGPFYTPLKDVTTPGVSLDEIDPRTVESLKDGVSRVILTGVGEGPISVDQHLVSEKGDILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZS8</accession>
    <name>A0A370PZS8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_3973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="57906" checksum="55833CF7AC83AAC7" modified="2018-11-07" version="1">MGILSDLTLPDSTHHEPISSLLAYIACLSLLSVISYVLYIRYYSSLAKVPGPFWASLSRWWLVLFSDKGNMHRLYPRLHEEYGKLVRVGPNEVSVADLNAIQLIYGAGNKFAKSDWYSVWQGRRKFDLFAERNETIHGAQRRLVNNIYSMSSLKDFEHGVDAVVERLMECMQRQGSDATVDLGKWVQLFAFDVIGEITFSKSFGFLENGTDGGAFGQIENALRSASWVGQVPWVYWLHDYMTPIIGSRLGIAARHGTIRQIAAREIMARREGKHVEEAKEEQDILSKLFDVQKKKENQLSDDDVLSMATSNVFAGSDTTAISIRSIIYHLLKNPTCLKKLRDEIEDLKRQGRFSDPVTLDQANDMPYLQACMWEGLRLHPAVGMSLPRVVPKGGIMIDGCFLPEGTTVGVNAWVVHRDASIFGDDVEAFRPERWLGEKTGDMRRYFFAFGGGSRLCIGKNISWMEMSKMIPTLLNRFDIQLANPDEPWQETCWWFVKQEGLLVKLSPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q018</accession>
    <name>A0A370Q018_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_271832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q018"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="292" mass="33192" checksum="E87AE101E226A90B" modified="2018-11-07" version="1">MSHLQQQLKSFNAGVMDYAARMPQQRRFVHNTNSASSSQLPSSTSTPTPSDDARRKRHDADIVYSQPANTGTGKDIMTQVVFAIEHMKSKGVPLKFADIVSYLSLQHRANDQGYVQALRSILQMHEKVQYDPSGANGEGTFSFRPPHNIRTAEQLLQKLQSQSTGAGMSVRELREGWPNVEDTINKLEKEGKLLVTRNKKDDHAKMVWANDPSLIQHFDPEFRQIWEKIKVPDQQAVKEELERAGITPTNKNKVVKARPKIENKKVKKPRRSGKTTNTHMMGVLRDYSHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q028</accession>
    <name>A0A370Q028_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small nuclear ribonucleo protein complex protein Nhp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_331554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q028"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="233" mass="25105" checksum="3956834C74361AFB" modified="2018-11-07" version="1">MAKERTEKKDKREKKEKRAEKDGVSKTSKKEKKEKKDKVALADAVEKELTTKVLDGIDQAATEAPVNGAEAEHMDVDSRPVGAIVPFASPLVEDKSAKKVLKSVKKAAVNKCLKRGVKEVVKALRKSPIPAANASIGVPNGVVILAADISPMDVISHIPVLCEDHGIPYVFVTSRAELGNSAATKRPTSVVMVVPKSASKGKKKDGEDDGEDFTEVFEELAKLAQKEAKKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0S0</accession>
    <name>A0A370Q0S0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_9408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0S0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="47434" checksum="9D897C9A29B9089C" modified="2018-11-07" version="1">MHSENRKPLRHIPLSYNHADSHASALRLILTLNPHWEGSDNKIEFVRFTDGITNTLLKIINRKPGLTEEQIDQEAVLMRAYGNHTEILIDRERETSSHALLASHGLAPPLLARFNNGLLYRFLRGRPASPEDLATPCIWRGVARRLAQWHAVLPIKGAAAPLMPAEDVSLMQHVDVATAHCQKLKHEDISVITPKQPGPSMWSVLQKWILALPTTTEEQRQRRLSLQKELERVVSELDDGKGLGDGGLVFSHCDLLCANVIVLPESASSEDETAVVNFIDYEYATPSPAAFDIVNHFAEWGGYDCDYNMLPTRSVRREFLTEYVKSYSHHKGIPESSQAEIVDRLYEDVDRFRGIPGLYWGVWSLIQAQISQIDFDYASYAEVRLGEYYAWRREVDGSRIQANEEMPLREQRWAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3L2</accession>
    <name>A0A370P3L2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_271636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3L2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="462" mass="50948" checksum="097CD32BB0715E84" modified="2018-11-07" version="1">MELMIPYPDLPYQQPPHAPNLELAETPAAGFLRVWTNEHGLFNPSSIEYVQRAVDMRSMKELTWSEADSSGLSQALLARARSLTSEHSTLSAHLAEVFDAKLAKRVGELAPIASTLKEWEHANSSISELLSLLDDPETDAELRSLAVEDLESSKIALPAIADNLKKALIPRHPFADLPCLLEIRPGAGGDEAGLFAFEVLRMYIAFCSRRGFRYSIIKQDVADGPAQDRLSEAVLEVDADGAYDILRTESGVHRVQRVPATEAKGRTHTSAVSVMILPSFPDSGSGLDSSLNFEDPNSDYYVDPQEVRTEKMRAGGAGGQHVNKTESAIRLTHIPTGTVVSMQDSRSQHANRKKAWQVLRARLAEARREAREQELVNLRRGAMGGVARMGRGDKIRTYNYGQNRCTDHRSGLTIHNLDSVLDGGEGLETVMDSVRTWLVEREIEAMAAEESVQDKEGLRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3L7</accession>
    <name>A0A370P3L7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_116058</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3L7"/>
    <dbReference type="SMR" id="A0A370P3L7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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            <end position="505"/>
        </location>
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            <begin position="47"/>
            <end position="75"/>
        </location>
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        <location>
            <begin position="466"/>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51192"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK36461.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="505" mass="56685" checksum="5904C5042555736F" modified="2018-11-07" version="1">MTDALASQLNNTTLGDASSDAKWKEQLNVPAKDARPQTEDVTATKGLEFEDFYIKRELMMGIFEAGFEKPSPIQEETIPVALTGRDILARAKNGTGKTAAFVIPTLERINPKSTKTQALILVPTRELALQTSHVCKTLGKHLGINVMVTTGGTGLMDDIIRLNDAVHILVGTPGRVLDLASKGVADLSECPTFVMDEADKLLSPEFTPVIEQLLSFHPKDRQVMLFSATFPLIVKSFKDKHMRNPYEINLMDELTLRGITQYYAFVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHARMLQQHRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHLGLAINLINWEDRFNLYKIEQELGTEIQPIPQNIDKKLYVYDSPDTIPRPIANPSQPQITAQAANANIGERRHNHHMNGGQYQYGRGRGSYRGGRGQGQRRNMQNETKFGTQGQSSGKSHPTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3X8</accession>
    <name>A0A370P3X8_ASPPH</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_226126</name>
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    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370P3X8"/>
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    <dbReference type="GO" id="GO:0000785">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VerF-like"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
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            <end position="150"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="760" mass="84568" checksum="62547A7B93C11AD7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4V2</accession>
    <name>A0A370P4V2_ASPPH</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4V2"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="58952" checksum="498A5003CD9B4035" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5F7</accession>
    <name>A0A370P5F7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_287248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5F7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="210"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="694" mass="75984" checksum="E336D2D498EA2D83" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5J3</accession>
    <name>A0A370P5J3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_259188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="481" mass="52636" checksum="9210C21876582582" modified="2018-11-07" version="1">MAASEYTPLLEPSTRPQDRSSRWRVLALICFIVLIQDFAEYLSQAPQTEIWLEVVTRKFCPVGQDGPECQMDRVQREVALLQGWKDTLEQVPGILFAVPYGVLADRIGRRPVLLLCAVGFTLSDTWTKAVGWFSDQLPLRLIWLGPIAQVLGGGTQVATSIMYVILADLFSDEEQITAFLYVAATVLVSEILATPLSALLMTKNIWLPYLLSPAFNAAGGLLLFFLPETLPQTPPSQPSSSEQASQRQTFRGRIRAGVDELSRSIAVIWRHRPVQLFLVVFFIAYLGMQVMKLLLLFAADRFHWTIAQASFLIPVRGFTRLLLLLVILPGISRWLIERRRMSPFTKNTRLALTSSACMGVGCLLIALSSHPAGAVLGLVVYALGSAMHLFARRIITSLVDAHHMGTLYTAIAVMQGIGVLVAGPMMATAYGWGLAQGGVWTGAPFLLVGGLYGAAGLAILLGSWEGCKDDLEDGRCSETIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P621</accession>
    <name>A0A370P621_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_321917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P621"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000050">
        <property type="entry name" value="Exosome complex component rrp4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="11">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="10">
        <location>
            <begin position="459"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK37323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="739" mass="80500" checksum="06FAE54AE9EA9F12" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P652</accession>
    <name>A0A370P652_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_279837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P652"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000594">
        <property type="entry name" value="RNA binding protein Rnp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001044">
        <property type="entry name" value="RNA binding protein Rnp24, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="73"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="371" mass="41164" checksum="9286306C251AD851" modified="2018-11-07" version="1">MAGVGEENHKKRKLPDVPEIEIDVSAPEPPSKKALRKLKKKAAEGPSDTTTEKKTEETPVDNDKAATQKRSDFGIWIGNLPFFATKDDVRKFFTTNCSFTDTTITRIHMPKSGDKHGKAQNKGFAYVDFSTQKACQEAMGLSEQLLTGRRVLIKDAKNFSGRPEKPQGEGQNANSGAASGNPPSKRIFVGNLGFDATKELIEEHFSQCGTIANVHVATFQDSGKCKGYAWVVFEDLAAAEAAVKGYVLVKEDDEEDEESDTESRKKSKKPRQKRVWVNNLLGRRMRMEFAEDATTRYKKRFGKDGEGKKNNTSDISEVEPAENNSAGEQSRQSRPGKARQGKPDYTRYDQDTVQKLSGAIVEAQGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6K7</accession>
    <name>A0A370P6K7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_89291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6K7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="113" mass="12662" checksum="139596AEACA8B434" modified="2018-11-07" version="1">MAETCERLWGPSSLFSFRYLPMPLKTSRSTQRGLRCCLSTMLRLGEGLLSATYSENNKVASSGDYTEERRWNSGCVSFLAPEAMKTKHLSDRRGVMATGAHSSRESAYVDQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6R1</accession>
    <name>A0A370P6R1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_308944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6R1"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="316"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK37565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="488" mass="54639" checksum="6CA4A95210406453" modified="2018-11-07" version="1">MPSTSDLADPKEYQKIFHWAETQKDGTIPSFATRRNDPYEYQAGFGNSFASEAVTGTLPQGQNSPRNVRFGLYAEQMTATAFIAPRHCNKKAWLYRARPAVAHQGFTDLPDNKDTESNFLPLNPRVHVSPTQLAWYPFDIPTNGEVDFVSGLKTVAGSGEPTLREGLATHVYVANTSMTKKAFVNSDGEMAIVPQQGALDIQTEFGPLFVQPGEIVIIQRGIRFRVELPDGPSRGYILEIWGSQFELPELGPLGANGLANARDFLYPTAKYEISKEPWEVVYKLGGKFFKSTQNHSPFDVVAWHGNYVPYKYDMTKFVNVGSISVDHIDPSIFCVLTAKSRDPTAPLADLLIFSPRWDVASHTYRPPYYHRNAASELMGLIYGDYGGRSDAFQPGSVSFECGMVPHGVAYEEFKAATEVDPPAMRISEASMAFMFESSRPFTITDYAWTSNKRHEHEPKMWDNLVDNFSKHEKEVEELLAKKAQGMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6U4</accession>
    <name>A0A370P6U4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_339625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6U4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="341" mass="38358" checksum="C3D9B8DEA365ECA9" modified="2018-11-07" version="1">MARPDVGQVVAWYICTVAACIFLVFRLIIRWRLLKKLYLDDFFVVAAALCLIGDLGIQHYMFTQGMSEIAKTTTAEKINMQKLIIPGSTLYVTSLWLIKASMVLFYKRLADRTKYQTIYNITLGVLAAAWLVLFFDIVFKCYPPDRQWKSFENPDLTCSEKQSTINYWLTILFNIFSDVFIICLPISQVARLKMPRKQKLGVISVFLLGVIVVITSIIRAIYSHLGEQMITCTVSMIETAIAIIASCLPVLRTLVFGSHSRTGTYSGRRGYELSNSGAAGLASKQHTTVSVSRGGPDELSRHDSEDELVKENMSAEDPTAGISVTREYFVHEGAMERQSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P734</accession>
    <name>A0A370P734_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_321714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P734"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="92"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="411" mass="47311" checksum="D765269BE63EA485" modified="2018-11-07" version="1">MEPRRHFYRLYKHCHLSFARPDSSSIARISSKVAYPRRCAHTITPAQKPRVFPGSGWENIDLSVLIEEESIPTYRPEKFYPVRIGETFNHQYQVVGKLGYGSTATVWLCRDLLGHCYVALRVYITSTSISQELQIYNHLKSIRSDHAGQSCLRPLIETFQILNPDGHRIHTCLVHPPLGISLDQLTPLLPGKVMSSSMVRTTMRNILAALDFLHTEAQVIHTAPVPRKSLSDRTIYVSRPLPISFGTPVLCDLGEGRLGSDNQQGDIMPDIYRAPEVMLSMNWDKKVDIWNVGMVIWDLFEHRHLFKARNDEGKLDDGQHLAEMQAVLERPPAQFLARSERSPQFWDADGQWKGAVPIPEYDLETLEERLEDGEKEDFLRFLRRMLCWLPEERASAKELLFDPWLMHGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7L6</accession>
    <name>A0A370P7L6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2 type zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_307994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7L6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="95345" checksum="15318C1776CC66DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P883</accession>
    <name>A0A370P883_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane Pth11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_78371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P883"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="39094" checksum="A6E01AFBD732456F" modified="2018-11-07" version="1">MAVSPLDVPNRGPEFVKVTAVLTCIAFVLVVCRLTWKGYVQGRFAVDDGIIAFSMGMQIVNTVMGDLACHYAFGRHKADIVRTGGNVVLALKYFWLFQIFYKLVLCLNKLSFLTFYLRVFPNRIFRIICWITIALVLASTFGFVIATIFQCLPVRASWYKHIPKKCVQNAPFRWSWAGYNTAMDIWVCLMPLPVLAQLQLDRIRKIGVILVFCMGLFVCVTSIIRMWAMEKSTTTTDQTWGSFDALLWSAIEASTGIICACLPFLKHPIQKVLPGLFGSLSTGSRKSRSRTRPSYRMSRLGSRSGNGTRDVDADIGGDGDDTESIGSQGPIAKNQIIVKTGISMHSEAAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8B1</accession>
    <name>A0A370P8B1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_222304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8B1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="128"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="331" mass="37566" checksum="B4BC7258359E140C" modified="2018-11-07" version="1">MGPADELLDPRRRDLIARLSRFMENPETDSIGWACLWFADLSTMEDLIKACEQNPPTVSRHISAALKKNDQRAQAIRAWASARSSEDSGEPSADKESDTEEPPTKKRRLTSDPCRAKELCEERDDEKCVLTGFTVPVEVVHIIPRSLGKGEEGLSDFWEALECYWSSEKVSAWKEQVLDPDGVETCSNLMCLVNVARRLWELAVFALKPLSLSEDKRQLEVQFYWLPMNRYQQTMPVTAIPSPFPHNLSSTNAEYTTVLCNIVTDSTIRSGDIFTFKTDDPVGHPLPSMQLLNMQWILTRVLALSGAAWVTEEEPFPDRDNEIEVEEEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Z2</accession>
    <name>A0A370P8Z2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_307350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Z2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017050651" evidence="15">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="114"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK38660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="426" mass="47262" checksum="069F9592E0E3E201" modified="2018-11-07" version="1">MKIHQCLITILAALTVSVFAASSNGTEFPECAVSCLHQESPNCTITDASCVCTGDASKSSLVTCALSNCSALDYYITRHMYELECDQPIKKGPPLVDPSTLAPAILATIFFFIRIAAKLANLAGGWGLDDLTVTIAWILGVALFVVNTYMIKYGFGMNTWDILPFHHVTLVFQYFEGLAMMYKIQISLCKISVLLFLLRIFQSRVFRVCAYILIAINAAIGITFSLVDLLRCVPVHLDWDSWTGEYEGVGTCINFIAAVLVHCLVNIFVDVVIVLLPIYEVTKLQLPWMKKINVALMFMMGLILTIIAIIRVIVFWENRWTNNLTAGLQPLIHWSVIESQIAIMTTCLPAARAFINQYVPGLPGSTQRRTYGRTNSLYNNGGASSGVTNSKISKSVNISVDYTTRSERDSTSAVHLVDMDGRYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P929</accession>
    <name>A0A370P929_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P929"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="71593" checksum="70391C5E22B54EE7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9E4</accession>
    <name>A0A370P9E4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_306841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9E4"/>
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    </dbReference>
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        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="637" mass="69288" checksum="AD870357CC08E9C1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9S9</accession>
    <name>A0A370P9S9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_269521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9S9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="253" mass="29606" checksum="3DEDDA0525E614EA" modified="2018-11-07" version="1">MSPRWFGQDEVSPGIVIELENRWRVLSHEEEVVMQAGERNTATQCRPYACILLKVRQVGSRPPVYGNMRIYKQIPTEETVGDRPEVRAKRARVWVPLELKAYRQLMLKDSTFTPRLLDSLEEKQDADSLVPGGFMVWVVSEEVSGIRLGDEESDDIFWSMERNVRQQIRDSFKENYLKMVSWEWIPFYCHCEDLIWVPGTSTLFFVNWFMPDEVVAPDDWEDRFFYASGLLRPPASSTFPIQIWNNSVEGWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9X1</accession>
    <name>A0A370P9X1_ASPPH</name>
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        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_338371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9X1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="193"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="39905" checksum="5477A41816F2638C" modified="2018-11-07" version="1">MGSLGEPTVCHGASVPDITTKGSEFESIASWRERVGINTDAQIRLVKLSHMRYQHPDLDQITVFLKDFGMQIVKQTDDQIWYRGYGPDPYVYYARRGPKQFLGATFEVESYQDLEKALQLPNASGIKELLDHPGGGHFVTFTDPEGYPVNLIHGQAPRETGDYPERLIVNYEADKPRLRKFHRFNVGPAPVHKLGHFGYCVQDFPTMLDFYTRNFNLVPSDFLYVEKDGQKVNVAVFAHIDRGSDPVDHHSFFMSTNETSHVHHCSFEVHDFDTQQLGHYWLAGKGYKSVWGVGRHILGSQIFDYWWDTTGNMVEHYADGDLVTDETPIGYGPAGDESLAVWGPDVPATFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW9</accession>
    <name>A0A370PAW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="542" mass="59950" checksum="951759409B5E0A9D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB39</accession>
    <name>A0A370PB39_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_285896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="691"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117165" checksum="6F9D8235FC13E086" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBM7</accession>
    <name>A0A370PBM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_54161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="209" mass="23332" checksum="7E80A2B3D47003B2" modified="2018-11-07" version="1">MDFHLVPRGEDRNYTGFLTKTIVYTASLIVFLASFGLTVASIVVPKWVTFTDSDPRWRYTYGLHRRCSHVTGLCESFPQKDDCHGDDRYFCSMWRSVGFLMSFAIVLEGMSVVAYLIVLSGGKRLRESGWKIVSLLIILSAAVQAASMSLVAYLVDNEDRFASGWVLDESWIFCTVSWCVSLFVAGVLILAGNTLPSEGGYELIPDQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBM9</accession>
    <name>A0A370PBM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_50603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="170" mass="19140" checksum="2269E73E45183191" modified="2018-11-07" version="1">MKPILRQPKLSHLCSGGLRARPVNTQKAPYTLLSSDRCHNITQRMARLNGGSPGLCKGQRNGQEDLVECEHPIRHPYALSLLNRAISQCDGCCYCTSLIGYRGLDSNQAMQSRSFWGVFLRYDLSPPALLETPLGRPEIDSNLFFRLNPVRQFLVTWMATSQDAVFRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC73</accession>
    <name>A0A370PC73_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="163" mass="17798" checksum="75E53E185362FF52" modified="2018-11-07" version="1">MPKTHPNDGLVFLYMCILNSDLTTIDWKALGEATNLKLGAARMRYHRLKKNMDAVIKDGKFDLSTTSASTPAKKQSLDMITATDKESSVEPNSPVVGTSAGVVSIAALLNKSPTKRKMADDDDSEAETIIDPSFRDLPVYPPYMHTGGPLAFKPTAKKVKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC87</accession>
    <name>A0A370PC87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_278193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35703" checksum="D32DA22CACA11A78" modified="2018-11-07" version="1">MEKLPTQSKADTSGYVDLSESSVARPISTRRDRVVTRLAACLGLITIAFLALSWTPISISGFKPFSCHRWRGQHDVSFPPDLGREEAPLMNGPPHELSTLDGSRLASSNRIPLEAHVMSKCPDARDCLQQLVIPAMEQISDKVDFKLSFIAAVSNKSSEIQCMHGPTECIGDMLILCAANLPFPPESGAMCSKHARTPTIRSLGFANCLISSYPDIPKRDLVQGCALEHGIDFEALNKCASREYDDLDDDDDSDEKTPLSGIALLRQSALHSDKLNVRTSCTLRLNESTWCVRDGGVWRDCAQEGEGSKVSVLVDEVKKLWDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCC6</accession>
    <name>A0A370PCC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_285644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="391"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="484"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="632" mass="71095" checksum="B3B5E0A7DD5247E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCG4</accession>
    <name>A0A370PCG4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Beta subunit of fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_304273</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 16" id="KW-0520">NAD</keyword>
    <keyword evidence="5 16" id="KW-0521">NADP</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="18">
        <location>
            <begin position="1695"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="17">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="17">
        <location>
            <position position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2096" mass="232918" checksum="5FE83A27594C2841" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCX4</accession>
    <name>A0A370PCX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="95" mass="10728" checksum="B17CDC74C79DDFDB" modified="2018-11-07" version="1">MFKATARSLYQLIGKTRLGDLPPEWQAPVGQVLDAEEKSDPRFKNAEIRGSKPHASHDDPTDPKDVVSVRIKDDGLKTFRRLHIHQDGSVKRIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD20</accession>
    <name>A0A370PD20_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_268521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD20"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="35391" checksum="05EA9ECD7CF22841" modified="2018-11-07" version="1">MSNQPERPWTEEEKVGLPILAPLPSQSPVLSADGGRSLNSCQIAFCNMLQHVQISVTHSLGSIPPQPHEPSVPATVPLESSSVLRKRPLIPSDRTIRAPRAIQPRPATSTASYSSESGASALLSPSSESVTARGEPPRKRGRPSKAESERRKAAAEARGETYPPPRRSGSHKLKVSSTPTSPSGVAPGLPSFSPQASSSRPQDLPRHEMHYVPPPGRPIPLMGPSSDERPRDMPNQDMSSSMRELPRPEIRQTLPSPGTLQLGHRETPLIRREPGVSFEPLPPDRHPFSQSNRRSLIHPTSRYPDEPPTPASDLPIARPPDHRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD71</accession>
    <name>A0A370PD71_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_328261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="262"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="12">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="470"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="452"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114702" checksum="F61493EFE11F78C1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDD2</accession>
    <name>A0A370PDD2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dihydropyrimidinase</fullName>
            <ecNumber evidence="7">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_218736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="73"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="56217" checksum="5636F4C908C6254E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF2</accession>
    <name>A0A370PEF2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001493">
        <property type="entry name" value="Mitochondrial ATPase (Afg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="558" mass="62185" checksum="8CABC0997B79F70F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF95</accession>
    <name>A0A370PF95_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_217963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF95"/>
    <dbReference type="SMR" id="A0A370PF95"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="837" mass="93455" checksum="9B0457AD9A1FE7FC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFS2</accession>
    <name>A0A370PFS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_284538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="20614" checksum="2C1D795E5BADB9D9" modified="2018-11-07" version="1">MSRPAERPATPSVPSSPLQGSHPGILTDSSRSESDPLLSTSECPGCRLPSVPELSTLAAAIPQLDLNTSAMLEERFLKTSAIHSTVGPTVRAAAVGPQDRRAAGHYVLIDLLCHGIFSTVRHQGGIQNFSLSWLEATVARDSVVVATATALYDAASLGLEEGEQMPPDKLFTDFGDFCLVPWPLRSTVPSHVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH6</accession>
    <name>A0A370PGH6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial F1F0 ATP synthase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_217697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15236" checksum="AB9120DF3F2C7B57" modified="2018-11-07" version="1" fragment="single">KAIGAAKDAARMDRVVNFYARLPRGAAPEVKPTGIIGRYQARYFGKNPSAAPLAHAIGTILILGYSMEYYFHLRTSPTFFWCIVQQDLPFHRSPQEPPPLSNSLFGFWEREILCIYHTLYNEDDVEESNLYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH8</accession>
    <name>A0A370PGH8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="288" mass="31861" checksum="B7F232F88FEBAE33" modified="2018-11-07" version="1">MSKPLAHASIVARRSSERGYAEHGGWLKSFHTFSFANYYDHRFNNFGSLRVLNEDRVAARNGFPTHPHRDAEIFSYILNGELTHRDSMIKKGAEGAQGKQFYRMKRGDVQFTTGGTGIAHSEQNESNKPVHFLQIWALPWKHGLKPQYHTRTFDEAAKRKAFVPILSPLAAGPEATPADEEAAIPKIPDTIPIHADFVMGAGIIEPGQKFQWTVGAGEDVVSRKKKRNVYVHLPMTKNGQAKIRLDHRDEAVFSEGDGAFITGVNAGDVLSVESVGDAEAEVVVLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH25</accession>
    <name>A0A370PH25_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_27705</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH25"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="18">
        <location>
            <begin position="179"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK41493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="500" mass="55910" checksum="2E12A3E3FE041CD0" modified="2018-11-07" version="1">MGFFDHLQKGGAFSLQPKKPQIRKVVQTRTAPASRSTSQTPGPSSRTPPAQLKAQHSASRSVSRDRDPPSAKRRHGTPAQSRKRQTPELRLSSDDDASDTDSSFEVRKRARTGDSAEPDPARRVRSLKAFSEDSVRSLPMIHAADITSRQKAGNFKPAFGAAKPLPELLLQYPSTSAPERYNLVVPRDHDDFKPIDDIVQVLDIVSQNYIPDEAADEFNNESTGIKRRLRRALAHSSEADFRSVVNEYNEAIVRLRRDGSIAKKLDSTSRLNLPHVERILNQIYSRTVSPRVESLRQYENGTDNVYGELLPRFISTIFKETGLKSGQVFVDLGSGVGNVVLQAALEIGCESWGCEMMDNACDLADLQQAEFRSRCRLWGIAPGKTHLVRGDFLKEQPIIDVLKRADVILINNQAFTPQLNNELINHFLDMKEGCQIVSLKSFVPAGHKIQSRNLNSPINLLKVKQRNYWSNSVSWTDVGGTYFIATKDSSRLKAFVDSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH64</accession>
    <name>A0A370PH64_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnogalacturonan acetyl esterase rgaeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH64"/>
    <dbReference type="SMR" id="A0A370PH64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629632" evidence="3">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="27601" checksum="F803FE74A5A11723" modified="2018-11-07" version="1" fragment="single">MKVSSLPILAFLPTSLATTIYLAGDSTMATGGGGSDTAGWGDYVAQYLSNSSGITVSNQAVAGRSARSYTREGRFDDIASTLEAGDYVIIEFGHNDGGTLSSTSDNGRTDCSGTGSEVCYSEYDGVNETILTFPAYLENAANTFQKIGATVIISSQTPDNPWETGTFVDDPPRFVEYAEIAADTADTSYVNHFAYVDQVYEALGADTVDAFYPIDHTHTSPAGADVVAKAFLRGVVCGKLSLADELVTDDLELDEYECLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHU7</accession>
    <name>A0A370PHU7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="29780" checksum="7D8D43CAB9D8528C" modified="2018-11-07" version="1">MPNLSQIPREIFDLIAASLSPNTAGQWNFETDSTTKKLADALLFSESQENILWRAIFKSDGWIDKAFELGACPALVGPELHEIGRPSYKGSHRHHVLLSTNDYAGDLQYSQDLLFESLREGYRYEPTRFRIVLPEITFVSPNKREMKIPEIALYVHDAIGPQETLVLSRRTIRKLFEKSAVRTQYSFASQKKICTVQSPAIYGVGGSISKPEQLLPICGMHLVCRGKEWLTVLTAPKCPPVSPVTNDGHRRRGRIIGWEKRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHY6</accession>
    <name>A0A370PHY6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_283975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHY6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="55374" checksum="913AE3A02C6926C9" modified="2018-11-07" version="1">MDSVTIIRQHQSSIRVLQPILRAYALGYLSSTVPRVITCLRRIRGHGLSFGEQLKELSATLTSTLRLDAFPAFCAILVGGSTVFPLILFRCLAHLIRRLGLKPGRLNALIHMRLARFVSALLSAWFSFNILNQRPIRLQRNCDDCQGGTDSKNAAEQRKLRPEPHSRPQLAGRTMDLTLFSLTRAVDLVVYMGWANWRRWRKSRGQWTLVERVAPQLTDAGVFATSAAIVMWAWFYMPERLPRSYGKWIGEVAKVDGRLIEALRRARQGVFVYGKDTGQAPLLQSMCKDYNWPVEWGDPSKTIPIPCEMVHMGSGHSCEKHALSRFTRTFKFACATYIPLQIIFRLRSVKSLSSLKQPITAALRSSAFLASFVSLFYYSVCLARTRLGPKIFHRGIVTPMMWDSGLCVGAGCLMCGWSILVESARKRQEISLFVAPRAAATVLPRYYEKQYQHRERIAFSISAAILLTCLQERPDMVRGVFGRIGRSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI80</accession>
    <name>A0A370PI80_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_216380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50028" checksum="121746032C7C98F0" modified="2018-11-07" version="1">MPRLVRRRPLTERIKSYLNPLDFLLWLSEEIDTHDWDQFEKNWALPLGIALNVVFLIARANSQSYGSQAIDDVFGDDGSTPWLSWFSSFIVHLLTTFTAFNAFYTFYRKRHYRMFEASIDQAPATPSAHRVRVNSTPVTASPLKYLADTIARSAQSRAHPDAQRDVWELAVWDPLPICIRLFCLFSPGHVLVYWVFLPTQLSDPRPSVTIVTTIFIAALLSVQMTFLSSSYTQQAKDSMVVHKEVLREYDTKYVHPRTQPLMRDVATQFSESDSDVKQNKVDTFTPTVVLHRGFKTSPNPNYVSHVDPEGRSSVRQSFAATPTGVSHRAAALQTPSHLRDASPIVRSSISAIRQPQFRQTPTTTGDGGSLGIYSHANSPLKKSTPANLERRLQSNGDFFYKERGTSAMRRPSSPLKRSNVPAGSPLTPGPRRSQVDARRDSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ07</accession>
    <name>A0A370PJ07_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_234153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ07"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="622" mass="69501" checksum="D7D3976FCB5667EE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJJ9</accession>
    <name>A0A370PJJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_335958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="333" mass="36285" checksum="79EE494C1C315A6E" modified="2018-11-07" version="1">MASTADVLIIGGGPAGLATALALSRKLHSVLLFDSQEYRNRQTSHMHNVLGFDHVEPARFRSAIHDTLLHRYTTNTIINKKITQARKLPHDGVGTRFEITDEDGTAYRGSKLVLATGIRDIMPAIEGYAENWGQLIFHCLFCHGYEERGAQNAGLLVAESSQLHANPSVGLILGQMVRRFAEKLTLFTHGNEETTVALQQAGAEARGFTIESRPICSFERVVSAAEDSRDILRVWLGQPDGSENPNSYVDMGFLTHMPDTVVKNDWSSQLGLELDESGIYKQKDVTMETTVPGVFVAGDHASVAKDVPNAASNATFVASAVAVQLTVEHSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJU7</accession>
    <name>A0A370PJU7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_276338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="148" mass="17043" checksum="E9FBBF00D866ADA7" modified="2018-11-07" version="1">MSSLLGLDGTQLLKPVVALAGWTFVQETWMYATRIPAIYKYNVSFDEDKVKHDKYTKIPLKVQRMADNYNNLHEQPQVFYVIAVVLTLLGDHNDFTYRLAWSYTGMRIVHSLWHNLVNEPNTRFALFSISSVMLLGLTARAASLLFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK35</accession>
    <name>A0A370PK35_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="57" mass="6057" checksum="E27D8D1734760B57" modified="2018-11-07" version="1">MRKDGDLGTISTAHCTTLYITFITISGPELVYARVLMVSSSNLRRKGVVATGISAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKJ5</accession>
    <name>A0A370PKJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_315071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="472" mass="51631" checksum="B790F8E26FAA2B68" modified="2018-11-07" version="1">MASTRMSAQSTIADLRVPDYPSNCLQFTQQLTASTTQTLPQRDASVRLNIILAGAGLGGLATAIALAQAGHAVKIYEQTPVLGEVGAGIQIPSNSTRILFSLGLQSYLEPYVTAPESISFRRWQNGKVIGLTKLIPNFVNNFKAPYYVIHRADFHSALCQKALDVGVEIELGAKVVDYNPIVGSITLADGTKHSADLIVAADGIKSVARNVVLQGDEMRFQGPGFAAYRAVVDVGKMRRDPDLSWILEKPALNIWIGDSRHVMTYTIGAGKAFNMVLSHPEMTDPGTWKPETALEDMKAEFQGWDPILSKIIGMVEKTVKWPLLTGTLLQNWTVGKLVILGDAAHAMVPYMSQGAAMAVEDGIALSRSLSHMTSKDQLQKALSIFQEVRKKRAGHMQEASLLNGKLWHFPDGSLQQARDEAMAPEVQGIPFSHSPNQWSDPATQMWCYGYDAEEAIDIAWMESLEARVDCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL06</accession>
    <name>A0A370PL06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="473" mass="51689" checksum="17DBE85D054CA757" modified="2018-11-07" version="1">MAAAALDQLRSIFPDDSTDKVVINESTDKYQAAVTCPWSQTCWTPAAAYVYLSTVQELTKALAIVQETGTKFAVRTTGHNPNAGFSSAGEAAVVLDIRQLRSKELLSDQGIARFGSGNTWGEVYAWLEERGLSAIGGRDSQVGLGGFLLGGGMGALPNLYGLGADGVKNFEILLADGRLVNANRNENSDLYRALKGGGSNFGIVTRFDLETHPLIKVQYTINLYNPEDYVAINQATFEVQQTMEEDPRIGLFTNFNNGFVAVGLLYGDHPAESEARETFKPFHNLKSLMTTVLPSTNGTLLSLAQAMGHAQTSLKRAICTVTTRNSTALYDEVYKAWVEVRKTLPADTVLHYTIQPFGKAAVQAGKERGENIMGHESVPQCWWVFTCEWPKDGDDAAAQSAVDIMSEKVQYLAKDKGLLLEFKCMSFATASQRVLGSYGVDNIKRMQEVAAKYDPEGVFQKLQNGGFLLRDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL38</accession>
    <name>A0A370PL38_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="84" mass="9394" checksum="7211BE0B496B5014" modified="2018-11-07" version="1">MADKLRTIQNLEAMQARYIGTGHADTTKYEWVSNIVRDSYASYIGHPPMLSYMALGMGESKEKVRAAMIEKMVRGAGNPPETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLE2</accession>
    <name>A0A370PLE2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_293184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLE2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="100"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="35026" checksum="7BDA382A15D3D34B" modified="2018-11-07" version="1">MPRLHPTTILLFPLRVLTIPFTTLIARIPILRSRHRRTRTLTMLLPLLVLLLILLTLLPLYIIYRPPHALIRSLANKYPDTLWEIPLPTTKDTKGKRTEKVIALTIDDAPSTYTLDILHLLQQHDARATFFLIGSQIPGREGILHTLVKSGMELGNHAMHDEPSVSIGEEVLEREMLEVDGVIDRVYEESGVKRPRYEDGAVKKWFRPGSGFFNGWMRGLVQRLGYKIVLGSVYPHDAQIGWAGVNAWHVRSMVREGSIVVMHDRRSWTVEGLRRVLPVLKERGYRVVSLGEAMEIANAASTDGGKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLU2</accession>
    <name>A0A370PLU2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLU2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="560" mass="61658" checksum="CBAC0E22366CAC6F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY5</accession>
    <name>A0A370PLY5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_213881</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="358"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK43207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="579" mass="64883" checksum="C34938D3E92537E8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMF8</accession>
    <name>A0A370PMF8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="217" mass="24131" checksum="90BABAF23DACB643" modified="2018-11-07" version="1">MNTTPITINKKEVEISPHLLSKYPFLLSPLSSLPTTHYPTYTDFGVGAYIFTTKPQLQQNNSNPTSKPLLLLLHRSPTDSYPLHWESTGGGADPSLDDTLLSALCRETVEETGLQVTKVVDLVAVDEWRKALPGGQGEKKVIKWGFLVEVEETNSVKLNPEEHCAFRWADEDEVRAAVTGSATDGEGGMKFIGDQGRNLLRAFEVYRDWYTPSEDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMF9</accession>
    <name>A0A370PMF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="283" mass="31439" checksum="43D79FFD71B7F977" modified="2018-11-07" version="1">MSYILTLSCPDRPGIVHAVTAYLVQQNLNIIDSSQYGDPTSQRFFMRVHFKDESSPAKSLDDLRTAFQPTAESLTMTFQLVPASSKPRVLIMVSKIGHCLNDLLFRASTGQLPIEIPLIVSNHPDFATLAATYNIPFLHLPVTADTKPQQEGRILELIREHNIDLVVLARYMQVLSPMLCEAMSGKIINIHHSFLPSFKGAKPYHQAFDRGVKIVGATAHFVTSDLDEGPIIEQNVVRVNHAMSPKELTHAGSNVESNVLATAVKYFAERRVLLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP7</accession>
    <name>A0A370PMP7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_157593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="314"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="678" mass="75967" checksum="E02532801B694BB3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP8</accession>
    <name>A0A370PMP8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_250212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="56265" checksum="59AA6178AB170139" modified="2018-11-07" version="1">MSPRISQDVERDFDKSHVDNVEIVTDGVANADKPNPKKEAPAYVASLSPEERERAEKALVRKIDLRLLPMIIIMYILNYLDRNNIAAAKLAGLVTDLNLQGVEYQTCVSILFVGYLLMQIPSNLLLNKFGKPALYLPGAMMLWGIISTCTAGAQNYAGLVVVRFFLGFVEAAYFPGCLYFLSAWYTRKELGFRTAALYSGSLISGAFSGLIAAGITENMDYKMGLRAWRWLFIIEGAITIVVAAISIFILPNFPRTTSWLTEEEKQLAAWRLEEDIGEDDWVDSEQQTFLHGVQLAFTDIKTWILMLLILCIVSSASVTNFFPTVVKTLNYGNIETLLLTAPPYVLAVICAFANAWHADRTGERYFHITLPLYISVVAFILAATTTSIAPRYVSMMLMVPSLYTGYVVALGWISSTLPRPASKRAAALAGINCVSNASSIYASYMYPDSDAPRFVTAMTVNCVTAFVAILSATALRFILVRLNKKLDRGEGLGDGGGVPGQASSRGFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN28</accession>
    <name>A0A370PN28_ASPPH</name>
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        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_159143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="238"/>
            <end position="537"/>
        </location>
    </feature>
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            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="60533" checksum="FC0BC13983831D25" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PND2</accession>
    <name>A0A370PND2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0047 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_248948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PND2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016835062" evidence="2">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="438" mass="49022" checksum="445134D3F6604D9D" modified="2018-11-07" version="1">MWLKSKYIVVALLAAPAAAVTPISNDEMTNFLSQGAVELATRYAPLWFLGQAVDQPPCYPTWAFGGSPNSSDIYDEAHKTPAAPQCEYPDVGCGCRKPGIVTGNPGPAFPIYYTFKQCNETEVRVVYNLFYEKDGAEVLDLIDTGHDYDWERVIIIHSRNANNTWQPSRALLSAHSGYHNLAWGSIHSTLTTEQINAGDARKPDGVKNNDHPKVYVSWSKHAHFDTVDTTWLDPLSQSLDNAFRSNDWWHFVDPKYYIRSDNSTAAGKAFNSTDWGSATSNPPYVQESQTSPNTMSWYQKSFTLPARSRGSYLITDHVLEQLPEIKNYKVGMLNLFVQHTSCALSLNENWDDDVRADMSDALDRIAPYDKKGNLYRHSAEGEDDMPAHIKSALIGASVTIPISNGRLATGTWQGIWYLEFRAMRHSRKVVATIQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE0</accession>
    <name>A0A370PNE0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_156927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="89"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40768" checksum="F49A105D6731942A" modified="2018-11-07" version="1">MSLSTVLTRRVVLGFAPSLIESMISMQKCSLRAAVGTLRLSCPPRTGLLESPRALFSTAHLKEERQLCKEGTTTLQPIPLKYRIPRGTWDTHMHVVEPERFPVSANAVYQPPEHTVDDAMNFESTLGIEKIVLVQPSIYGTDNSCLLEALKTLGPSRGRGVVVIDPTNIDTKTLEEWHLLGVRGVRVNLKSVGKVLSEHELTETLLQHAQIVRPFGWTIQVYVSLDMVPLLERVVPQLGVKLCIDHFGGPDLTAVQHDGESFNPYMLPGFSSLISLLRGGETYVKISAPYRLSKDEEYRDLEAMAQEFLEAAPDRVIYATDWPHTRFSGVDIEPFTETCLRICAKESGLAERVFRDNAEEMLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE2</accession>
    <name>A0A370PNE2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Aconitase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_248964</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1224" mass="133029" checksum="56980E2272FE3D23" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNN5</accession>
    <name>A0A370PNN5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNN5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="199" mass="22105" checksum="42F56FCE406888E2" modified="2018-11-07" version="1">MSATWFEQQKRSFADVKIDAANDNGISTTEFLEAAESLTTLFDVLGSKAFTPVKSDLTNNIKKVRERQLAAPAESETLQALVVNELKTKKHVASEGLLWLVRGLDFTAQALRHNLNNGSTELSDSFREAYGNTLKPHHSFVIKPIFSAAMSATPYRKDFYAKLGEDQAKVNASLDAEVVALEKNVAILKEFQGRKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPD8</accession>
    <name>A0A370PPD8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_264937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="38803" checksum="27B45ABBDD376362" modified="2018-11-07" version="1">MALTQPSTSERTIRKIDIAQVSLSLQDRLGLAKVKYQNGRLQALGPNHNGGIQVCLGSDRPSDSSSEVSHSRSETPLTPPPLPNSSYSKELPRSSRNRHAATFDSKAMQPMLSASRKRLRSDSITDRTIKAPRVSWKSSHHLPESSPGFNRQHLNRHLPIPFMSDIPEYSSPAYPPHSEDDNDPDLPVHSFQHVSSMAGSSPPRTPPPKHARLSRNDRQLRHADGADLLLYLANSPTPAKPQQARDFPPSTPPSQHAALPSLTPTPGGGGVFPNFGTPNQQFNFADFVNVTPSPAQPPWGGRTPGGPSRTPLANKERKRSNLDGLLPPSTDSPRNRGKGPAMVLQLGEELRPEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPR7</accession>
    <name>A0A370PPR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_264097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000007">
        <property type="entry name" value="Cytoplasmic protein required for cell viability"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="199" mass="21398" checksum="66DD427F7D372953" modified="2018-11-07" version="1">MESAMQNSNPTILNAADLPTRLRPSSRKAGTYRGGILASALPSPADPTDFSISESEESDEDVDLMEEPIDEQEIYDLVSTISDPEHPISLGALAVVSLPDISIKPTLPDVPSSLLRTVSVLITPTITHCSLATVIGLGVRVRLEQSLPPRFRVDVRIKEGTHSTADEVNKQLADKERVAAALENGTLMGVIAKMLETCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ24</accession>
    <name>A0A370PQ24_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_137974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="87" mass="10507" checksum="0DC79C29896712BC" modified="2018-11-07" version="1">MGMFPFSTFLILFEGLSHHFPVHVCFSEKKERFLFDFFFLFLFQTHSSPFSYLYGYLMQRERNIVYYSSSTIYLLYSFFSPSALCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQD3</accession>
    <name>A0A370PQD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_264309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="14783" checksum="F9E0D2D25A091140" modified="2018-11-07" version="1">MNEETFNFGSSRAIINMFEENTGTYDHRVWKIGLPVRSAVLKPHAESKVSGKWQENGRKMAGTWQEHGRNMAGTWQESVGKLLTSLNPEAPIAAIYCLLAYAMGQSAVIEWMVINELLVLENWRCEIGLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR57</accession>
    <name>A0A370PR57_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_264568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="36968" checksum="295C9D34A04A704D" modified="2018-11-07" version="1">MNVRRLDIFYEIRDKTLAGDIPLVFFREFDSNFGHEKLGWLKYFLAPMQDSEFFDHGSRHPLGRAVFVFEQGTEHFHGFPETDLNSSLFPGAKLPDFVSRLRGQIQIGNKQAEPGDEQLGAGDTQTDPGNIYKALENIFTWYLSDNKANKPLSIGLFQNIPDPHRKVNEDFRTALKGYDMNYFPIRRAILLQSMLERIFKFAKGKRIEMDTGVRNALLFTPTVLRGHRSLESILSMSKINAGNPIEVNDICKEDQRKLHVKDPRFEQYLNGKINPPNAERDEQHYAWIERKSGRAYKPRPVVKSDTTTTTPTVSSSASGSGSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRE1</accession>
    <name>A0A370PRE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_282044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="43"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110867" checksum="7030326172749B18" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSH7</accession>
    <name>A0A370PSH7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016728349" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38420" checksum="13D50B3217BB3D47" modified="2018-11-07" version="1">MWTFLVQFFSTVLQFRLSMTKPSETIVAYDLTSTALPCYVMEYAPLVWLYSKETYMPSDIGQQLVHTTPMVNYTAIKGAPSPLTLNNLAGLNKLGNTSVYLTSIEGIDATPEPAWFRGVKPDRNGKTKGAVSSTIITRDHGNGTVDAFYFYFYAYNMGNTVLGMQFGDHVGDWEHNMIRFDNGVPQALWYSQHAGGEAFTYDATEKQGKRPIAYSANGSHAVYAVHGTHDHAIPHLNLPFGFVMDYTDKGTLWDPIANAYAYSFDAASQTFQPYDRRYPVNWLEYNGQWGDDALPGGPELFGQAKYSAGPNGPKFKHLVRSTVCPDSPCVVLPFRIWDDEDGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSJ5</accession>
    <name>A0A370PSJ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_333964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="43506" checksum="DEACAE197A3DE2F3" modified="2018-11-07" version="1">MAEVATRKCMGVDCDKNAGTLQCPTCLKAGTDSFFCSQDCFKRSWSEHKTIHKKSNFLANLFTPKVVSEPDPATGLYNPFPAFQFAGNLRPVYPLSAPRTVPKTIPHPDYAKDGIPRSEQKFVGRNNIKILSKEEQEGMRKVCRLAREVLDIAARELKPGVTTDYIDEVVHKACLERESYPSPLNYYNFPKSVCTSINEIICHGIPDQRPLEDGDIVNIDVTLYHNGFHGDINETYYVGDKAKANPDAVRVVETARECLDKSIELVKPGMLFRDPGNVIEKHAKSRDCSVVKSYCGHGINQLFHCAPNVPHYAKNKAVGVAKPGMCFTIEPMINQGTHRDRTWPDDWTSSTADGGISAQFEHTLLVTEDGVEVLTARFPDSPGGPVPIPAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSK6</accession>
    <name>A0A370PSK6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSK6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="884"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116166" checksum="02B66F10F407AE38" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSM4</accession>
    <name>A0A370PSM4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_230407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="41933" checksum="4252C00BF500336C" modified="2018-11-07" version="1">MGNESSTLIDEKTPPSVLEARTIEAIAKYVKQKPVKRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPDPEAVFDISFFRQNPRPFYALARELAPGQFRPTIAHSFIKLLYDKGMLLKHFSQNIDCLERLAGVPGDKIVEAHGSFATQHCIDCKAEYPEDLMKKAITKGKVPYCTQCKGLVKPDIVFFGESLPADFFDNRDLPEQADLCIVMGTSLQVQPFASLPAFVSDGVPRVLINMERVGGLGSRPDDVLVLGDCDTGVRRLARALGWGEELEELWERTNPDPAARAAENASPQTREERLQDEVDRLTEEVDRTLGISQAYQQRVRQHLERQSGTHADAAGRKEKQAEEENDRIGGLAHVFPHLARMQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT44</accession>
    <name>A0A370PT44_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIIE, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_324325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="49916" checksum="23F28F52EE154F70" modified="2018-11-07" version="1">MDLANTLIRSVVRAFYETRHILVVDALFIHSVLHAEDLAFLLGMQQKDLRKLCAKLREDRLISVSTRAEIRDGSTRPVNREYYYIPLHPVVDAIKYKVSKLTSTIKAQYTPSQERKEYICLRCGSEWTELDVLSLYSEEGFECQNCGAILERTEDVKGAEGIDRTGHEKNSKLMNQLDTMLKLLKQIDSVEIPPNDFDTAWDHKIDVVRNQQTHPTRAAVIVPSKQQQEAVRGNTKTDATALEISLTSSEEKSAAEQAAEAARKAAVEKQNALPVWHTHSTVSTSAGNGPHVKSETDIDIKPEIKPEDEDRKPEINGLDDKVAAYYAEMEREKALQAQEDASSAEEDSDEFDEFEDVGVSASDAAASPAVNATPTPGGGPTSAPVQQTSTTSSVGIKRELDTDYSSVSTSQTAAATPATGGEEGPTAKKIKTEPEVKKEEESDEDDDEEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT63</accession>
    <name>A0A370PT63_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_273691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="29984" checksum="FE31A3CCD8DBA77A" modified="2018-11-07" version="1">MGCITVGVLALQGAFYEHIQLLKSAAADLPAKDRSSASQWDFIEVRTPQELERCDALVLPGGESTTMALVAARSNLLEPLRDFVKVHRRPTWGTCAGLILLAESANRTKKGGQDLIGGLDVRVNRNHFGRQTESFQAPLDLPFLGANQPAFPAVFIRAPVVEKILPHQEGEQVGEAQREETVIAPARQAEDEVARQAMADSVEVLAALPGRAARLACEGTPINADDETGDIIAVRQGNVFGTSFHPELTDDARIHAWWLRQVEESVKKRHAAHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTR3</accession>
    <name>A0A370PTR3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_311697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTR3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="449" mass="53654" checksum="94691B07DE6CF60D" modified="2018-11-07" version="1">MDRSPLGQLGKLPYEIRLEIYEKLFTIKNSPLKILRCSRAIYGEITDRLYDTLNIHLSPVFNDPWIEIHCKRLRLRWIIPNHSFPCQHRFARAPYYKMNLVVHIYAPDPRDPGQIALLWQKVQYLVYILERATISSIVIRLRVHQGRDWQKEGRVVESIPYPNKSRPDHHIVFLPFCRLSNVRAFRVVPDTRRMDRVTDWGLINYGRDFILNNGYRNYNDGPLSQDRQYRDIVREFDDIDALIRDTDFFLETHLDTLHGNTAAMLRLDRAAHWPLGAPVDYTFRLERSLLDIRQYPGSVNLHDPGLKQHCLRMWAFCDLYLIPYPMKDKRSWEEWCSLYPEGLRPHDHESIHDPLVEITDNPGYFGNFDTTQIDGEYEINIHNYWQRNWNGRPAFRRRRFEQAWCTDCRRIGYRTGCDQDCEKLNGSDYEEDWEFWSFNASDYSDPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTR7</accession>
    <name>A0A370PTR7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="42660" checksum="7CB5F7071449C60E" modified="2018-11-07" version="1">MSIYSNIATSKERHDQIQAELAAVESSPESLQSQESYLAELRRELTNTNRQLAQLHKVTKGNRELHEKYRDSTVRRLLYRARGKREEFEAKADQEMRDYYDALAKENRAQAQREMLEAQVADAVDHEKELQRACTTRERLHAELDTIYKRIFEGRTEEFPEEDAQEETTKQARREYGQRRERWSDLRQATQCLARAQLTLREVLLNLAETLRYCERDLWTFGSTLADWRQQDCLSRAQQKVTQTQMLVAQARRLDPRVQALPAMNLVQHDWVGELVFGTFLFHTSFLDMMQQSVLEVKRAEEVLAVQVRQAKSREDDMQAQVEEARVAFETAQQDLRQIRYELFMKTADPPPPYTEPMSPGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUU5</accession>
    <name>A0A370PUU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_289495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016612483" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16059" checksum="F59B445DC9C8D379" modified="2018-11-07" version="1">MRFTTFSVLLLSTLALAFPESGPAIEKRDDTTDSDMPNPLSNLANPTTTMPTLFPEVPTSIRSDLITEVPTSVISEMTNPTAWSSVASEWRDGIVPSWYSSLNGDVKSYFSTAFETASPSTSSSHGGAGPGAPKPTGMAGIMGAAGILGMAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUX3</accession>
    <name>A0A370PUX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_95856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="121" mass="13584" checksum="FB88E3C14001FA66" modified="2018-11-07" version="1">MSIPNEALQKLLQEIEVQAITSQQQIGITKAQITTKQRDIRMLELTSKEISSLPKDTRVYEGVGKMFVAVPMNTIDKRLSSESGDLKADITGLEKKLHYLEMTHKNSRENLEQILKSGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUX7</accession>
    <name>A0A370PUX7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000074">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="341"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="630"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="864" mass="96254" checksum="93CE6253A71C8A1D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUZ5</accession>
    <name>A0A370PUZ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_317200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="460" mass="50237" checksum="52915E7429D1A57B" modified="2018-11-07" version="1">MADDSDYKLKCDASLSEEIENVITSPFSPEEEKALVRKVDLTLLPTIWIMYLLSYMDRTNIGNAKISGMQADLDLTSGQYSIALVVFFIGYVVFEVPSNLVLSHTRPSLFLTGIMVIWGALTCVMGVIKDYKHLVVLRALIGCVEAGFAPGVLLVLSSWYKRTEQSKRFGVYISAAILSGAFGSLLAAGIIQGLEGVHGIRGWRWLFIVEGSATVGVAIICAFILPDFPATSKRLSERERYVAITRLATDNVTSLTEDSPELSHWHAVVESAKDWRTWGFVIGTLSYFYPTLVEGLFGDSSTERVNFLTVPIYAVAFVCTAITAYFSDRIPQWRGLVIAGWLSASLACSIAVCVVYNYTARYVLLVLMAAGLWATNGGTLAYASSAFANMHPQVRGVSLALVNALGNLAQIYGSYLFPSSDGPKYIMGFSVISAMLALGVIVFLVIHVWFRRRAAAIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVK1</accession>
    <name>A0A370PVK1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="727" mass="83415" checksum="9FC27B4431E2C80B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVP7</accession>
    <name>A0A370PVP7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_309486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVP7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="33011" checksum="846E6C2A8A05616E" modified="2018-11-07" version="1">MIQTHHRTATPKGLSSITTLLTTPGASLLIDHPFLLADAQSTIHWIKSLTPHAPTAIFLTHHHPDHFFSANPILAAFPDAKFYAAPYVCSRINAEYDQKAKYWPAVLGTDAVPAAPRKPDPYLSSFFLLDGSPVVLLGPVQGDCVDQTVFWVPESRTVVAGDVVFGRSVHVWVEELESPALVHSWLKTLDMIDHLHPQKIIPGHMEEGWELDVKADLDHTRRYLRLFAEKVTYASGSGGGKPSVQELYDTFREAFPECRENLEFFLGHMANRFGQGERYGRRIGMRMSGRGLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVT8</accession>
    <name>A0A370PVT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_209030</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="11">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVT8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="17">
        <location>
            <begin position="155"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="15">
        <location>
            <begin position="670"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="16">
        <location>
            <begin position="796"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK46299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="923" mass="102547" checksum="8D06B2220DE7B012" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXC6</accession>
    <name>A0A370PXC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_332148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753258" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="212" mass="23715" checksum="9F0695F23B2B4BAE" modified="2018-11-07" version="1">MVLGIAMMAAMVPTMIGLNQASQNMRDSEDSRKESSRKQRCHLLVNCSVSQGTTAQREQIHNAMVYVGPENRLYITKNPNPETMTPFNGGFFTHPQFPPDNTAGLVTITGETPPTLRWVFLDVTTHEVRWGGRAESEGQVCGPFDWTKDESRITLEGWEGWLAVRFPGVDEEGVWRLWFDRDDDGAGLKDLGEKGMEVQGLEVVLKRVSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXF9</accession>
    <name>A0A370PXF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_272656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="640" mass="71668" checksum="4225E9D1EDB186D9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL4</accession>
    <name>A0A370PXL4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_272705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951432" evidence="7">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="486" mass="54668" checksum="DF6A8962244B9112" modified="2018-11-07" version="1">MAAFRSHHRRRIALIILGLITVLTWTFAASRSQSANRVTSHEQFWSEFYPILMASEPYSNSPKRVSNAESVGFDPKNTDPLPDLLRLSREDVSAMRLSHSKFVDLIRHNPPSLHYQPHTRGLVSTAGGSYLPVLVISLRMLRRSGSTLPMEVFLASWDEYDGYVCQIVLPSLNAQCVVLSEILDSIADSRSIEKYQYKVFAMMFSSFEEILFLDADAFALEDPEILFISEPFASKGLVTWPDFWRPTTSPLYYEIVSQDETAGKNKEKQENPATIRQSTESGELLLSKRTHTRTLLLAAYYNFYGPSHYYPLLSQGAAGEGDKETFIAAATALNEPFYQVSEPIRAVGRGTPDGFAGSTMVQYNLIEDYALTKKGEWRIRGASVPPPHPFFVHVNFPKFNPATVFHDNGPVVDEKGRYTRAWTAPDDVVEAFGGKKTEKAYWREILWTACALEGKCISWKGRDDICSKTADYWSTVFEGGEGLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXU2</accession>
    <name>A0A370PXU2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXU2"/>
    <dbReference type="SMR" id="A0A370PXU2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="216" mass="24151" checksum="8B5240DA8AA9F64C" modified="2018-11-07" version="1">MNRLFGTKNTAPKPTLDGAITNVETRISSIDVKLAALNSELSTYQTKISKMRDGPGKTALRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKTLKKQYGQIDIDKIERLQDEMADLMDVGNEIQESISRAYDVPEDVDEAELDAELEALGEETMMESSMADSAMPSFLQDEVAPPQFIDEPPEQTKVKEPASGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY18</accession>
    <name>A0A370PY18_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_262021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="281" mass="31326" checksum="547754A52F3E5F59" modified="2018-11-07" version="1">MAPISIKAFQNTLRVAATQHRHNYTNIHSMTYFQNLLKTLNIPPAIEHIIRHSSPNPDIPFQQAFHDILDESQPKTKSDHNLLIFHYAGHGFIKNGQLTFAETATAEKTLNAGISTRAPIISNRVVEILAATSTQIPRNRILPENTFTAKLAEEIACRKRSGHKYVEIADVFQTLRSRGERDRLRPTHALLVGVESVVLPLDGSCAVDPVTVAPMCTALFSVSVAKEMTAEELRQLSSWMKNLPCFAGLEVDKGYSLIAEDVRAPIDLDNLSTGYEKYHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY80</accession>
    <name>A0A370PY80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_69930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000348">
        <property type="entry name" value="S-adenosyl-methionine-sterol-C-methyltransferas (AFU_orthologue AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="387" mass="43299" checksum="5614127430A0597F" modified="2018-11-07" version="1">MDTQTTVLASRQSGRSSESSSLDAVEKQKLANKELPQTRPDLHNSASPKRWKTFWKAFRYLNNLTPKQVDDFMASYVIYNLDWSDEKAMIETLGPDYQAKVGDCLKAYYGVLNHLCALGDVEKMYIPPFMSKKATVLENQLLYEESIAQDIGLSAGDHVLDLGCGRGRVAAHMTQYSGAKVTGLNIDPNQIGQAKTYNEKLGFTNNSFVVQDFNSLPLPFEDASFDAFYQIQALSLCKDLPSLFREIYRVVKPGAKISLLDWVSLPDYDPSNPEHAELMRRVKPLIGAVGTPTPESLEKALTDAGFSVVRSDNASVGGLQAPLIDKVDFYFRSMRQVILGLVKTHVLPRHFKTLINRLCLDGEAFIKMDTMRLVTTSYRIIAQKPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYB3</accession>
    <name>A0A370PYB3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_272687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="161" mass="17958" checksum="CDDBBDC24F463773" modified="2018-11-07" version="1">MLQPTNHIAPATSSCPSDAPVNQNTLQFHSAHQMTRARSRDRVLWIGSPRYGHPTRRQHARQQESRHGAHVMPVHLATRHAVLSFTTVLNLMHITLEEVKETRNESNGEDRVMTLVSELLRARMRNAGDGFKQGSGWCLNINSRVGMSIGPSVGEEYGVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN1</accession>
    <name>A0A370PYN1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_72215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37825" checksum="47669E6FCB69BD1F" modified="2018-11-07" version="1">MSDEPTILRPRPRRVFDLTPEEPSTPVEPANPDLLVPKDAGSTSVSRNASIMNLTSSTLYGIYSPTAFDSSRDDSSPWGTEAHTPQSGSPRIQSEAPAPGKLRRTRSRLSHGLFRGVILPQALKSAFLLGFGVVYGVITIHLHENHWITPVKLENTHYYGSWQYLAFWGVAGAVLGNILPWFDQFSDEIIGSPKQAKGSSDPETADRTLSWVSVVRSVGAFVGIAFAMRRLPWESTTQASLTLALVNPVLWYLIDRTRTGFVLSTVVGLAGMGIILGLKPDLIPSAETSAFAASKFDVTGWGYGLAVEMSQESIAVRTWVASVLFCACVCFGNIGRQLAIGVQRESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYX5</accession>
    <name>A0A370PYX5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M752DRAFT_271729</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYX5"/>
    <dbReference type="SMR" id="A0A370PYX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RDK47402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="151" mass="17169" checksum="89345B6BA251A556" modified="2018-11-07" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRKEYIKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ81</accession>
    <name>A0A370PZ81_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_271830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25083" checksum="8887F2D0071D55C7" modified="2018-11-07" version="1">MMRTKRTNTQPLEDASISPATFNDGLPLPKLIAFDLDYTLWPFWVDTHVSAPIKPRDNNSRCTDRWNESFAFYPAVSSIVYACKSKNIPLALASRTHTPDLARDMLKALHIIPTFSDNPAAKTKSVRALDYFDYVQIFPANKTQHFSRIQQASGVAYEEMLFFDDEARNRNVETELGVTFCLVKDGMTREEVDRGVWAWRKRNGIKQRKEGEAENGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF6</accession>
    <name>A0A370PZF6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_260923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="8">
        <location>
            <begin position="63"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="892" mass="100540" checksum="5C38E7A00EC3EB65" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZK0</accession>
    <name>A0A370PZK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General amidase gmdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_226690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="88"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="60680" checksum="8BA10A73740E7933" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZK1</accession>
    <name>A0A370PZK1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_271893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZK1"/>
    <dbReference type="SMR" id="A0A370PZK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="7"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="57103" checksum="24EC4AE583B69509" modified="2018-11-07" version="1">MDQRYYTLAEGCPYASNASSVQLRSGNGGLLLMQDTQLIETLSHFARERIPERVVHAKAAGAYGEFTCTHDCSDITSASFLSEIGKTTQLLLRISTVGPEAGSADTLRDVHGWAMKLYTDEGNLDWVFNNTPVFFIRDPLKFPSLNRSHKRNPQSHLPDPNMFWDFHAGNPEGFHQLLHLFSDRGTPASLRHINAYSGHTYKFTLKDGSFKYVKFHIKTTQGVKNLTKEESVRLAGENPDFLIQDLFEAIERKDYPTWNVYVQVMSPEQAENYRWNIFDMTKVWPHSDFPLRQIGTMKLNRNPRNYFTDIEQAAFSPSNLVPGVAPSADPMLQARMFSYPDAARYRVGTNYQQLPTNAAKTQVYCPYQRDGQMNFSDNYGADPNYVGSSLKPIKFYQDVKGQAPQAVSTLTEHEKWVGQVSNFQYGLYEDDFVQARGLWKVIGKEEGHQERFFGNVAVHLGQVWSGPLRERVYELFSRVDPGLGEGVKKATEEVVKKRESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZT7</accession>
    <name>A0A370PZT7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_226776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="624" mass="68260" checksum="955FAAE604633DB1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0A0</accession>
    <name>A0A370Q0A0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_331401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0A0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="762" mass="84115" checksum="1FE22FD15A4FE25B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Y9</accession>
    <name>A0A370Q0Y9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_272291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Y9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="388" mass="43984" checksum="974C56C9D075CF58" modified="2018-11-07" version="1">MSKSTKYLLVSFPTSITPSHHRDDALDAISTTVSSENGSVAPFPIPEFKIGTLDALVQQADELAKLEAGCQGVVAKVGDALKNILDGDEAQIDKMKTVNDKPVDQYLRTFSWNKVKYRADKPLGELIDLLQKEAASIDNDIRSKYTQYNQVKNTLATLQRKQTGNLSTKSLSSVVDPRTLVRDSEYIETHLVAVPAQQVKEFLKIYETVAPMVVPRSATLVASDDDFTLYAVTTFKKHSLEFVHKCRENKWIPRDFKYIEGGKEEERKEFERVGGDERKLWGETLRLGRTAWSEAVMVWIHVYVLRVFVETVLRYGLPLDFVCTLIRTPGTKQADKAKRNLDDKYSYLAGNAFGRDKKGRVKRDDPGEMHGEGGPEYTAYVYYEFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q193</accession>
    <name>A0A370Q193_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_280841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q193"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="504" mass="57686" checksum="F12260547E0FE727" modified="2018-11-07" version="1">MASLTLESLPVELVEEIVAWLDFHDHCALRLTGRSISVKSSNAAFRKYFLSKKLEIAEAPLEQFVSVTQPGRFGLWVQDLTLFASIALHAEVPPASPKVFELLAQAFQNIRNDSPHNEPLSITLKVFGDGYLKAAADTMFQVTMSALRRSGLPIRAFNAFAEGYSHTYGGRCSFPFSEIPDALFGGSTADLTRLATAFQPCKKIGLSLAHYIHNLDYIRPRESPLRPDNLFELPPSYEEARENTRSLPHLLNLCPTLEELHLVWEYDDFEETAGVREELYFFERVVASCQFQGLKKCTLSDIRMSEATLMTFFRQLTRLVHLDLTFIYLDGNFDGLFRLLSTAMPELNYLHLRSLYSSSGTVRFLHEPRNNIVRSPSCRPSRAQILIRRGADARRPVITRTRSDQEQFWNNTQITQNKLKVAQPMPTARLIAIYVEWEDLLPGKERLAVYRFGHNKRRENTETISLAHQSVPFWPQRYSVIHRSTSPHTRRNINEGSLQQRYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1M1</accession>
    <name>A0A370Q1M1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_13732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="16770" checksum="80EC41D64C36F166" modified="2018-11-07" version="1">MSEPLTKVDSAIAISPRDEKAPDKDAKKGHRRTSSHAEGVYNIKELEEKKIEITLPIETQKTGWKLNTSPSTIEDKDILKLHLINPPVKKIDLHFPLGLEVTARNMKGVTIKDALDAIYKQFKKKVSCSRRCSIRRLPSPPVILTSHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3I6</accession>
    <name>A0A370P3I6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_280473</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3I6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="13">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="239"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK36429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="667" mass="75393" checksum="1053B299669EEFF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3K0</accession>
    <name>A0A370P3K0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_187146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851882">
        <property type="protein sequence ID" value="RDK36446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3K0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="594" mass="68540" checksum="CCAABE893E7D6741" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3K7</accession>
    <name>A0A370P3K7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_226353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3K7"/>
    <dbReference type="SMR" id="A0A370P3K7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="76"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="404" mass="45818" checksum="17E0F71D4FF954C9" modified="2018-11-07" version="1">MNTVDIGRCSKRIVQYLWDPEPRNDEDPNSSIWCLGIEYHPDKDANTRETPDKNNTRENVMGTTNYRKPSEHAWPESFLLDFESRIWMTYRSNFPPIPRVEGDDKSASMTLGVRLRSQLVDTQGFTSDTGWGCMIRSGQSLLANALSMLVLGRDWRRGARFEEESQLLSLFADTPTAPFSVHRFVKHGAESCGKYPGEWFGPSATAKCIEALSSQCGNPTLKVYVSNDTSEVYQDKFMDIARNTSGAFQPTLILLGTRLGIDNITPVYWDGLKAALQFPQSVGIAGGRPSASHYFVGAQGSHLFYLDPHYTRPALPDRQEGELYSKEEVDTYHTRRLRRIHVRDMDPSMLIGFLIRNQEDWADWLKRIEAVKGRPIIHVLKQMNPDHDQEAGALDQVEALDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4N4</accession>
    <name>A0A370P4N4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_110643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4N4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="7103" checksum="70478687F4306621" modified="2018-11-07" version="1">MDSIKQNLENAKNKGKDYYNQMTGQQNSDASQYAEQAKTKANEGMDKTKQTAKDYMPNQAGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P547</accession>
    <name>A0A370P547_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_287425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P547"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="341" mass="37495" checksum="40EF00C403B99538" modified="2018-11-07" version="1">MADQASFGRPVVPGETVVSNEAVMPGTVSAAPSQFTIANSYMTTDILSMSYQGGEEQTLFAFSPVSPSLQGWSAKNDPQVFTNPGLERGLKNSHVRNGQPTPPPFDDKSVNGVDEVYSLSQYHQPYDGAAYANPTPRASFSQPAVSDAPQPAPKRRKANGTLDSSSPDSGDKLSEKAKREKFLERNRLAASKCRLKKKKQTETLRDQFKLLSERKDYLTRYIDALRSEILLYKNYLLEHAQCNDEAISMHLSTMVKNITQQDSLGASDLKTDLNALTPSSSSRTTRSQDLSFGFDSPIQMPSKMGSLEPTPRRDSEQTLASDASFSFSTPNNDAFEDLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5I9</accession>
    <name>A0A370P5I9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_279883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5I9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="464" mass="50268" checksum="2FE4DE7DFB133622" modified="2018-11-07" version="1">MGYGDEIAGMDNKSQNVMGGEKYDGDLVEKMSEGERNIYEAGIEKYNRLGWKRLTVVLIVEAIALGSLSIPGSFATLGMVAGVILTVGLGFVAIYTSYVVGQVKLKFPDVAHYPEAGRLMFGRVGYEIVYVMLGLQLLFLTGSHCLTGTIAFINITESGVCSVVFAVVSAIILLLFAIPPSFAEMAILGYVDFVSIIAAILITMIATGITASDSTAGLSGVNWSAWPKEGITFTDAFIAVTNIVFAYSFAMCQFSFMDEMHTPKDYVKSIWALGLIEIVIYTLTGALIYAFVGQDVQSPALLSAGSMVKRVAFGIALPVIFISGSINTVVLGRMIHGRIFKNSTIRFINTKMGWITWLALITVITWVAFVIAEVIPFFSDLLSISSSLFISGFTFYFPALMWFLLVREGKWNTPKNLMLGALNLCCLIIGLVTLGAGTYASVDDIILNYRNGSVRGVFTCAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5W4</accession>
    <name>A0A370P5W4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_279867</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5W4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753244" description="alpha-amylase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="35"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="567" mass="61459" checksum="1BE75A9E069145DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P666</accession>
    <name>A0A370P666_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_258660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P666"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="60812" checksum="3AB38AE75B21F1AE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6D9</accession>
    <name>A0A370P6D9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_279803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6D9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000034">
        <property type="entry name" value="Aldehyde dehydrogenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="499" mass="54041" checksum="D7ADDD44FE976015" modified="2018-11-07" version="1">MTETIPHVSNWVNGTHTTATTPRIPVINPATELPIATIDSTSKETVNQIVTESLKTFHNGSWSRADPSTRFTVLSTAARLLRSRLPEFIELETRQTGRPIREMRAQLARIPEWLEYFASVVRVHEGRVTPFKGPVVNTLTRLPLGVVALITPYNHPLLIAMKKIGAALAGGNVVIVKASELAPLSVLKLGALFQEAGLPNGVLQIISGYGYETGKYLCESPLLAKIDLTGGLATYKAIAPSASANLIPITAELGGKAPVCLFPGVGIEDAVKAALFASFIASGQTCVTGSRLLVHTDIYEEFTALLKKRVEKLRLGDPFDDMTQIGTVISKTAVERCAAFVERAVREGGKVLCGGRATTNPTSGKGYYFEPTIIETRPQTDLECNEVFGPVIALIRCQSEEDIIRIANASSLALGASVWTTDFYQAHRVAEQIEAGIVWINGHHLNDPSSAWGGFKQSGMGKENGMEAYESYTKVKSTVINYGVPPVWFDDEPVDARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Q1</accession>
    <name>A0A370P6Q1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_279593</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Q1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="52883" checksum="8413BC8AABC67E7C" modified="2018-11-07" version="1">MSAKSILEADGKAILNYHLTRAPVIKPTPLPPSSTHNPPPKLASLYFPEDVAVKDVLDQAEVRYPWLLTPGSKFVAKPDQLIKRRGKSGLLALNKTWAEAREWIEARAAKDVQVETVTGVLRQFLVEPFVPHPQETEYYINIHSVREGDWILFTHEGGVDVGDVDAKAEKLLIPVNLEQYPSNEEIAAALLSKVPKGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNADATSADVHFLDLAAKLDQTAEFECGTKWAIARSPANLGLPTLPSSDKVNIDAGPPMEFPAPFGRELSKEEKFISEMDAKTGASLKLTVLNANGRVWTLVAGGGASVVYADAIASAGFVSELANYGEYSGAPTETQTFNYARTILDLMLRSPIHPDGKVLFIGGGIANFTNVASTFKGVIRALREVAPVLNEHKVQIWVRRAGPNYQEGLKNIKAVGEELGLNMHVYGPEMHVSGIVPLALLGKQTDIKEFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7K0</accession>
    <name>A0A370P7K0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_222682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7K0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000296">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="59190" checksum="F3345D7FE8DCB63B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N9</accession>
    <name>A0A370P7N9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_308062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK38199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000228">
        <property type="entry name" value="FMN-dependent dehydrogenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="366" mass="40451" checksum="02B56C321E4CBBE4" modified="2018-11-07" version="1">MAHRGETFHKDVNCIADLKAMGSKKLPKMVRDYYNEGAMDLITLRDNEAAFDRYRIRPRVLVNVANIDTTTEILGTKVSLPFGFSPAAAHKLAHPEGELATSRAAAKFGICMGLSSYSTTSLEDVASQGCGNPYAMQMCVLKDRSITLQLLERAEKAGYKALFLSVDVPVLGKRLNEYRNNYQLPEDMQWPNILSDGKDTSDRTDYDASLDWDSAIPWLRKHTKLQIWLKGIYTPEDVELAIQHKVDGVIVSNHGGRQLDGAPATLDALRDCAPVAKGRIPIAIDGGIRRGSDIFKALALGADYCFMGRIPIWGLAYDGQQGVELAIRILRQELMITMALAGCRSISEIQRRHLSVLQADGVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7P7</accession>
    <name>A0A370P7P7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_339148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7P7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="333" mass="37855" checksum="860F0161AC162B78" modified="2018-11-07" version="1">MGTAPPIIDFEPFYTGDAEKKAELVRQVRHACERHGFFQLINHRVPLDIQEAMLQQARDLFSLPIEVKEKYSRELEPVNLGYESLRSQRFEKEGPGDLKESYYLSQDLPPGHPFIGRFSQGSNKYPDEIRDPGLFRNTVKDYHVVMSDLGLKIFQVLAQTLDLEENWFNGFCHDSANIIRLVRYPPQETDGQERGIGAHTDFGGLTILLQDDKGGLQVWDREAAEWADAEPVPGAFVVNLGNMLMRWTNDRYISNLHRVINRSGQERYSVPYFISGNLDYVVECIPSCKAETEKAKYPPITVEEWMLARYADTYGGGQKGAGELSQDAVRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7R1</accession>
    <name>A0A370P7R1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_329946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7R1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="215" mass="24348" checksum="C6D3E17007A28D18" modified="2018-11-07" version="1">MTLKLYGFVHSTCTRRVRTALAEKGLDVEIVPVDLAQGEQKTSSYLNDLQPFGKVPVLQDTETGIQIYESRAIAQYIATKYRGQGTDLAPPESDLKAFAYYQQALSIEQSYFDPLVSQIAYEKVFKARKGHGQTDEARVQSLFSQLELTLEGYERVLSKQPYLAGQQLTLADLAHLPYGVFIEQFGFTDVVSKFPHVQKWWEGLKARESWKKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7R6</accession>
    <name>A0A370P7R6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_297613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7R6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40672" checksum="3E402FA3BC3BF40F" modified="2018-11-07" version="1">MLLWIRAVDDNASQASVIVIPTIVTTVIAVVLTLLRLYVRKFVMRTLSWDDWFNLLATLTTLVAMALILAAVPYGLGRHYDTLDVDRAVYCVKLLRMCLFPLLFSTIFLKISISLLLMRLFLTTKMWKIFFWCFIAFNTVTSLLDAAIVLPQCGPVARTWDKRVDGTCWPKSAINGAAIAQGAIAAGTDIVLSILPIVFLWKVKIPIKVKAAICGLMALGFASAGFALARTQYVSTLTESSDPTWDYINLYMCAFLESSIGVIAAAAPSVRPLLRPGFWNKEYSRSRSRSFPLHTLTAKKSARPVWGDTLFDTRFDVEDRPINSRDSDSKLWPQLSMAIVKRTSIEVVTNSMTHSEVKAMGRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Y9</accession>
    <name>A0A370P7Y9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_81469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Y9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="56941" checksum="6E5DA0C6ECCEA9C6" modified="2018-11-07" version="1">MKNVRNDFLPADRKIATRDCRLCTKRRIKCDRTIPQCRKCTIRGHCCPGFDAVQLNWNHSMARRANQISSRSGFSHPQDRETKGYIVRHGTAILHTFVVEASPPIPNPLTDDGLSRRQSSTVLGERLINHFSCHVVSIFSWIDSHKNPWRKIVLPLAQGSISVRLSILNLAAAHLAATSTGTIALRMKQVNYSLRDIALRSLNQEIQRQLDCHAVKPPDQLCLTRILIAAITLCHAELVTRDSTDWTTHLHACRSIVSRYGVCARNQSLDPMTQFAIKEIRDVEVFNNVFSFSSSSKVATTAIEFQPWTFTDLINDITSMERHHYGYLSEGRQPPDVDFNIWQAKLEQASAQMSMSDITCLLAQGKTTRDGFEALIDTHYYATLIYLHQAFASPTSMMRTVSSTLPILLDRIQKVALASSDAFAQDLFFPLFIAGTECWGDEGKQQIVQQILLKLLVTTGLWCNHRALDFLRAFWSSSKHHGTGKWIQYGRDSKQQLGHFLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P879</accession>
    <name>A0A370P879_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_269882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P879"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="678" mass="75616" checksum="3C9B753493AAD684" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P946</accession>
    <name>A0A370P946_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_286291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P946"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:triglyceride catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="326"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="668" mass="74871" checksum="F82D8894130BBB09" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P953</accession>
    <name>A0A370P953_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_278931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P953"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="522" mass="56567" checksum="46CBEC84E87A58E1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P997</accession>
    <name>A0A370P997_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_296799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P997"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK38757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="56810" checksum="6AEF3922CE917977" modified="2018-11-07" version="1">MPTILAIVVISYIVYTACAAIWNIYLHPLRRIPGPKLWLAFPILRYISFMRGVLDRDMRTYHNHYGGAVRFSPNEVSFITTQAWKDIYGHGHRQLPKVPGSMSNPMDIISANDSDHTRFRKAISHAFSAKGLQAQEPFIMEYVDKLINKLHSMTKSQVAVDMAKWYNLTTFDLIGDLAFGESFGGLDSTEYHYWVSTIFEFIKAIAFAKFKDNYSMMFQVLERFLPKHLLEAKRRQDEYSWNTVQKRLHHQRDRGQADFMQSMLRHRGEKDGLTDEELAANASILVIAGSETTATLLSGLTYWLLQHPKEMEKVKFEVRSVMKTEEDIDVNNTTAKLPYMLACIDEAFRMYPPVSGGLQRYVPDTPTEISGYLLPPKTNVSVHQSAAYRSPLNFYRPEEFIPERWLPQSKNDPSSPFYHDNRDVLQPFSVGPRNCIGRNLAYAEMRVIFARVLWNFDIELCEESRDWHNQKSYNLWAKPPLMCRLKARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9H2</accession>
    <name>A0A370P9H2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_296848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9H2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF6">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="38190" checksum="C731B2D944BD355D" modified="2018-11-07" version="1">MGAMSLPSDEIPQTQTVALVRELGGSVEFREGYPVPTPGSNEVLAKVLYTGVCQSDLHTKNGTAAGADGNPITKIKLPHVGGHEGVGQIVALGPNCGADLKVGGLVGIRFASRICRRCEFCLAGTEQYCVKGTNHLHHEDGSFQEYIALDADNLTILPDDIDPKVIGPVLCAGVTAYKAVLNTNIRAGNWLVVVGAGGGLGHLAVQYAKAQGALVIGVDAADKRDFVLGLGATEFIDFTSTDPVQKVHEITGLGAHAVVVTAGSAKAFAHACDMLRVGGTLSCVGIPPGRPVLETPICTIVIKGLRVTGNLIGSLKECMEAVDLVRRGVVKPEIKVRTFKELPQVYEEMEKGDIAGRIVLQVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y7</accession>
    <name>A0A370P9Y7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_269384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="163" mass="18181" checksum="211E43B39E33681E" modified="2018-11-07" version="1">MFYRWGTLPNVIIDVAMLILPQPVVWKLQVPAQVKYGLAVTFLTGSIGMVTSICRCVAFFTNNPLTNGTWLSVTFLVWSVAEVGVYLIAACLPCYRPLLRLAINRGRMTSIRSRYVHQKPRRSSAGRITATPKPDVEMSPYIKAKADQCRESDEQVLVMKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA48</accession>
    <name>A0A370PA48_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-mandelate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_305646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="71"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38275" checksum="491958CE61931B06" modified="2018-11-07" version="1">MPKPRVLHIGDPIKYNHDVYARFASQFDIIRPSTEERARDAFKQALQERRWGDFDAIFRPFWNTGGEMGRWDEELISLLPSSVKIVASAGAGYDWADVDVFAKYGILYCNGAAASSESVADMALLLILSVFRNLRWSHSAAHSINATQFLDAHTNSPLTARNPSTQVLGIIGLGQIGYTIARKVHAAFGMKILYHDIIRKDRGVEEKVGAEYVGKLEEMLGKVDCVVVATPFAGRVLMDREMFGKMKQGSRFVNVARGGLVDEEALVEAVESGRLSGVGMDVHANEPYVHPRLAGNARVMMMSHNAGGTVDTHIGFEKLAMENIEGFLVKGRALTPVNAHLFKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAT0</accession>
    <name>A0A370PAT0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_296337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAT0"/>
    <dbReference type="SMR" id="A0A370PAT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="175"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="915" mass="104299" checksum="AA00890F10CC006D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB40</accession>
    <name>A0A370PB40_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_56374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="29240" checksum="66D18DAF46273276" modified="2018-11-07" version="1">MTSHRADASTFLDNRGYSGPLVRGVNPATLFEKAVRDRITDSYYWKEQCFGLNAATLCDRAVELTSIGGVYGVSEKPSPFLCLAFKLLQLNPERDIILEYLNFSDPANDEDSTGHEEREHDDGVVKARGDFKYLRALAAFYVRLTFEPVEVYKTLEPLLLDYRKLKRRVRDSFTLTYMDQFVDELLTKERVCGTSLWKLPARQVLEDLDLLEVRISPLQDELEEMERSDREEEDDDEKDDADEGSEEGERQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB53</accession>
    <name>A0A370PB53_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_269014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="255" mass="29109" checksum="D3CAE77641FE195B" modified="2018-11-07" version="1">MAERILMNEYKTLSQEPWVNIDRPPRHVSHRRPHSCHTENADRHPFQVDEQNLLHWTIGLIVLNPDSLYYGGYFKAIMKFPSNYPYSPPEFRFIRPLYHPNIYKDGKLCISILHAPGEDEMSGELASERWSPAQRVESVLISILSLLDDAEISSPANVDASVMLRKSPDEYKSIVKQHVEDSKNDIPEGFVMPTHESTTTVSKPVEKDDSDFWAESDVDDDVFGGSDSDEDLDVDDDDEDQDSGSDEEEDEHRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBG9</accession>
    <name>A0A370PBG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD-repeat protein Mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_53379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000194">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="7">
        <location>
            <begin position="179"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1450" mass="163441" checksum="E305F91C3858F238" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBT2</accession>
    <name>A0A370PBT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_54825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="12449" checksum="AB1393C880C75284" modified="2018-11-07" version="1">MNSQLNDDVSKARDKIERLLRNIEELQHTDSETQLQVRRAERELREEREKSLRLERELEGWRALRVERGSVLGRSHVGAFSDAGSRRGSSVYGGDIPQRMPSNTKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBU7</accession>
    <name>A0A370PBU7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="19785" checksum="BE965A3E43EFA3D5" modified="2018-11-07" version="1">MSFSNLISSALEQATSHSSGGGSGSGSYDPEFSSAQHHAQAHESSGDSSLFSSALGFLSDRKSQYSEQPDIDEEHLVQSHQQLYNGGGGYGEEQQHDSKSLGAGAAMQALKMFTSGGGGSSGGDKNEFIGMAMAQASKLWEEKSGSGNVSGDKQSAVNSAAEMAFKMYMKSQGSGSSGTGGPAALMSLASKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW2</accession>
    <name>A0A370PBW2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753095" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="83778" checksum="45E757CD3C3EF429" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCG5</accession>
    <name>A0A370PCG5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">3-oxoacyl-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_304268</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 13 15" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="17">
        <location>
            <begin position="1008"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="14">
        <location>
            <position position="1194"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="15">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK39882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1616" mass="177952" checksum="AFA0EFF7E8E12947" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCN5</accession>
    <name>A0A370PCN5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_268387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCN5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="128" mass="13646" checksum="56E6EEC710352FA9" modified="2018-11-07" version="1">MNCTGTIPISKPDLHQLFAEAVVTGLPGMVPGSELITGLAPIGMAQAETAFWAANPKFGLLVRDQTISLTVSRLGENGRSIAQVPVWIQLQDATSPQEVSTLIQDKNGRPMSGVVIAKNKVPDRDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD80</accession>
    <name>A0A370PD80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="19896" checksum="7D2434A86B30A529" modified="2018-11-07" version="1">MSQLARWVRAHPGNEVVVPMNVVRVVSLQEIFTIGTEGLGACSAIVIASSHGAIVAHIPPRPMASASDPYAGDNNVRRLMAEVTTLYMRYRDEYFASHTDTVIVCALYQGAIALPDQVQIMHSALRRLGPSVWTYDVPGNYTNPGQGTVLAIGSRGLASLGLLNDGRARIYIEDQQYVSRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD82</accession>
    <name>A0A370PD82_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_337651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="396" mass="42100" checksum="466539B28F71AFD2" modified="2018-11-07" version="1">MASQSMKALNYVGPFTVQVQEVERPKLEHPDDIIVKVTSAAICGSDLHMYEGRTAAEPGITFGHENLGLVEELGEGVTLLKKGDRVVMPFNVADGRCRNCEEGKTAFCTGVNPGFAGGAYGYVAMGPYRGGQAQYLRVPYADFNALKLPPGTEHEADFILLADIFPTGWHGIEISGFQPGDSVAVFGAGPVGLMAAYSAQLRGASRVFVVDRVPERLRAAERIGATPIDFTAGDAVDQIITLNGDMVDRSVDAVGYQAVGKDNSTEQPNIVLENMIRVTRACGGLGIPGLYVPSDPGAGDASAAKGMISLSFGKLFEKGLSLGTGQCNVKAYNRQLRDLIIAGKARPSFVVSHEIGIDEAETAYEKFDKRVEGYTKVIIHPNGGFPSKRPPAGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDT6</accession>
    <name>A0A370PDT6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_295540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDT6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="34906" checksum="7D3D050C382C9DC8" modified="2018-11-07" version="1">MSQEVGIDVHSGDFSSLTSKDPIQKYVISAFAAITFYNAIELVVLCFTTFQRYHGCYFWSLLVTSASLIPHCVGYLLFIFSTVSPYVPVSLIIPTWISIVTGHSLVLWSRLHLLVQSQKLLQGLLYMIIIDSIAFQIPTTVLLYGSLSNTPHFARGYDIMERVQLVGFCVQEFILSGIYVWETIKMLRLRPERSRFIILTQLLVINILILILDVAVVAIEYAGYYALQVMFKPVAYSVKLKLEYAILGRLVKIAQGASSDPDPLSPSSRGFNITASGFDESGSTGAGVTVVRQVNSGPLVRRWSGQTHDSLGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDX6</accession>
    <name>A0A370PDX6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_218757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Gamma-glutamyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="849"/>
            <end position="851"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="873"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="901"/>
            <end position="902"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113183" checksum="7CCA6E1548A9C4EC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE76</accession>
    <name>A0A370PE76_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_218902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="300" mass="33166" checksum="F312726CFB68B4EF" modified="2018-11-07" version="1">MQTTPESHVANGSSLITTFHLAQKAPLILQRQSSSVETFAPSSVRGIENYGVVEQLLFSCLQSGDDKSALLCTEQLAARFGVTDERILGLRGMYEEAVAENRSSLEECLQTYDLALSENPVNLPVLKRRIALLRSLSRPADAISSLIKLLDAVPTDAEAWCELADLYYSQGMSSQAAFCLEEALLIVPNSWNIHAFLGEILYSGACASETGDCSQLLEVSIHHFSRSIELCTDYLRGFYGLVLVGFPILRLDGCNLTLFARNRLDEIVRSRSSDHHSWKGNQGELIAAKELLHRLDNFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEM9</accession>
    <name>A0A370PEM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_328053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="247" mass="27568" checksum="D69D4E4456DE1197" modified="2018-11-07" version="1">MSQSLRIAILECDTPIDPIKAKYGPYGDIFESHLKEGLTRINANVSLQLSKINVVQPFAEYPKPEDFDAVLLTGSKHDSYKDESWILTLTRFVQDCYHIYQKPVIGICFGHQIIARALGARVGPNVSGWEVAVESVDLTSAGKRLLGRDTLAIHMMHRDIVYEVPPGCVNLGATLICGIQGLYVPKRILCVQGHPEYNEFMVSELLKLRRGMLGEVVYEDGMGRVGREHDGLVFCETMCRFALGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE3</accession>
    <name>A0A370PFE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MNNG and nitrosoguanidine resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_253791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="44"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="50901" checksum="4D68EB94C86E352B" modified="2018-11-07" version="1">MSSDKVQMAEAGDKAEVPPAAVSFFDPALKAVRRSVFFQWGRTVLILCVFILCILSLFWAVQFHAESRFSALTVWVVDFDGQLEPYRNETPIVGPIVTEVVDHILDTSTEHLGYTIKSPADFNNDPWAVRQSVYDEHAYAAVIINANATALLRNAVINGNSSYDPYGAAEFVTISARDPTTYYDYINPFLYDLDMAVRSSFGPRWIQYVAQQGYNISQVPQAINPGIGFTSVDLRPFAPAVITPAVSIGLIYLIILAFFNTPFMMPIHIQFIKGNHPPLKIPQWLLWRILSNIGTYFFLSLFYSFVSLAFQIPFSNPSAPDTQVAYNPNGYGHGSFVVYWMLNWVGMCALGFPCENMAMIIGLPWSALFLIFWVITNVATGFYALDLAPGFFRWGYAWPLHRIVEAIRTILFDTHSRIGLDFGVLFAWIGFSICLFPLAAAFMNWKIKRGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG76</accession>
    <name>A0A370PG76_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_294842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049373">
        <property type="entry name" value="TyrDC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21391">
        <property type="entry name" value="tyr_de_CO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tyrosine decarboxylase C-terminal" evidence="6">
        <location>
            <begin position="602"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123952" checksum="2E06E793623783B1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ9</accession>
    <name>A0A370PGJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="554"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="916" mass="103041" checksum="6CEE335BBB9A376F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGM1</accession>
    <name>A0A370PGM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein hob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_25942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="407" mass="46410" checksum="EE89D9D5E24EEF2D" modified="2018-11-07" version="1">MSLKGFQKSIVRAPQQFKAKFNIGEHTKDPVYLDAERRFQELEKETKKLHDESKKYFDAINGMLNHQIGFSKAMTELYKPISGRASDPSSYTIEGNPEGIRACEEYEAIVRDLQESLVPELEMIDTRVISPAQQLLEVIKVIRKVAVKRDHKKLDYDRHKNSLKKLQDKKDKSLKDEKALYKAENDVEQATQDYNYYNDLLKDELPKLFALEAEFIRPLFQSFYYMQLNVFYTLHERMQGINIGYFDLNLDIEEAFENKRGDVKERAEELSIVHFKATGGRKPGSKLGPKDKLAQEGKSGYASRQRDPDVVENPPPPYSATAGSSFTAAAKSKPAPPPPKPKPARFSAPVETVTALYDYEAQAHGDLSFSAGDVIEITQRTDNQNEWWSGRVDGREGQFPANYVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGZ7</accession>
    <name>A0A370PGZ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_252844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="405" mass="44822" checksum="858892CEC3C360FC" modified="2018-11-07" version="1">MRLTLPVVFSLAVASTARHGESSRVFNRDTSSFIHPGLLHTATDFSRIASKVSSNTEPWLTGWYKLTNSSNINLDYTPSPKTIVYRGADGTHTENYPSLYKDIAAAYAMAIYWKVTGNTSYADVVVNILDEWSSTLTEISGTTDMYLAAGIYGYEFANVAEIMRTYSAWPSANLTRCADMMVDVFYPLNHDFLQNHHGAAVDHYWANWDLCNIASVLSIGVLTDNETMFDEGLTYFKSGAGNGQIEKAIWKLYQVDGESLGQGQEAGRDQGHSMLDFALLGPIAQTAYNQGTDLFEYLDNRILAGAEYVAKYNLGNDVPYTTYNNSDDVNQTVISNSSRGDIRPIWELLYNHYGVLKGLDVTYTKEYRDMVVEDGDGAEGGGGDYGTTSGGYDQLGWGTLMYTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH31</accession>
    <name>A0A370PH31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_253375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="167"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="58812" checksum="2F1F353095A15EF0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHT1</accession>
    <name>A0A370PHT1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHT1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016959661" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18662" checksum="091C5D79352C2485" modified="2018-11-07" version="1">MKLGLMIIYILSAAVGSMGAVENASFVYDANIDKLVLKTTSFPAPQNRYDRSLPRRASDAAPTCSIEYGAAPLNETVANIAHLFDIADSTCSVGAATCARVSHEGSSSIFWCNFEGEVIYMRCGDLVGSTEQVSDACRVGDRYTYGYVSRSMVDGSQSYPYLVVIGGDYVFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHZ3</accession>
    <name>A0A370PHZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_327184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32317" checksum="82DEA26B562989C5" modified="2018-11-07" version="1">MHLLDISIKFAETCQHPDIKEHIVLSEHYLLCDSLKLARIAIEARKEIGAAEKQKHYSAIRRISTHFKEQFESQQTENSRNKPRYERLLSQHRTILALDLEASTFLNDWTGVCAIIEESCPFIDEKLSSVFLDRLLRSDAQLKTKVQAVKTLLRTLHASPSPFLDKSTFIVKSLPRYIRCLFQLSLDTAEYQLAESILDQALILAQGKQTETGNDNKRPLSGYPDDEIRWLSTVAFNRAVDYYLAAADMHCRRWAGKAINLADLVEDDGALGRLLRGKLEMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI00</accession>
    <name>A0A370PI00_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_234930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001205">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001861">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002324">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4672"/>
            <end position="4874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4040"/>
            <end position="4522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4542"/>
            <end position="4563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4115"/>
            <end position="4141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4145"/>
            <end position="4170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4179"/>
            <end position="4190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4192"/>
            <end position="4217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4218"/>
            <end position="4234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4235"/>
            <end position="4275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4285"/>
            <end position="4335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4370"/>
            <end position="4396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4427"/>
            <end position="4450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4451"/>
            <end position="4466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4498"/>
            <end position="4508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="4886" mass="545352" checksum="C0C586FCB08AB95F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI07</accession>
    <name>A0A370PI07_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immediate-early protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42614" checksum="D630C4FB2BF6EC4E" modified="2018-11-07" version="1">MSHGGLSRSSMFSQIVTAAKGFLSRQDSDESSLKNLRPTTTTTTSGAPSGIKSSSNTPKMVTATRQRKFPAEQQQSSTEPEVNGSNGKRKSEPVGAEPTETQSKNKRRKRSSLEATTQESESKPSSNKKSKKMTEPTEEPEEQQEEEKKPSAAPAAKKHLRFDSEEPEIPEVAAVEDTTEAQQDQDDESSDDDEAPETVDNSAQLSKMRMEAKKQERARQIEEQLKRDKRKQLDELRKSQAKLAKKKEAKAEDLLSESTETLQGTTTQDARRSALPALLPDDILNAAPDVRPPTPPAEERTIMQKPNKLRFLDKKEKPPKDARVGDVTIRVLDDGVSKKPSKTVLPPKASKTGRNAKQNWLNKSRNTGALNGLRRTTGGSSGFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJH0</accession>
    <name>A0A370PJH0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_335950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="277"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="680" mass="77039" checksum="D02C6ED5B0B7EE76" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKC2</accession>
    <name>A0A370PKC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_319208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49455" checksum="B3068977ABA3E976" modified="2018-11-07" version="1">MAKIFPADSPLCNLFSTAPKKPTQNVFASPESPPKTITDYPQPCVSPYASPVNHITIGRTTYAIPEYYVLKIPNLKFAYMKEFALEEMYADIGHTFIHYLYTGEYETLAGSPSLPPSKSRAREFKRSVYAFHMAQRHQIQGLLEHAKRYMYTFVDSVSTLDLLKIAREVYATMFTGRKWFEDFVHDQLAAAFKAGEEQFRNDILKYGVGSDAKFDQFILELVMKIYSESIAKLTKAAANGSASGLDTPASGEDASTDQTTVVAEENEVKSDPEASLDGSDDGVKDSKPADAVPEQPDEKPKSLSPAPASPLSFTFRSPQPVRHQSFIPEPASPKTQPKAEPELKPRKPSKPAASPKPIPETTAHPEKATQSEKAPFDKPEPNPKFTPRSRAQTPENAPSDNNSSPRKKSKKKRGGKNKNGNSNASPNLVNGTPKKWEPKTTPESISFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKI0</accession>
    <name>A0A370PKI0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_214620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKI0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="44681" checksum="CF0B7B5FAEED4755" modified="2018-11-07" version="1">MNKESLQSIWTDVQLSLEAFQADGTEYNRIDALEKATQLARALEKPRDAILKLAYTPTALMAVKVAHDMKVFPVLANATSPVSVSELAALKPADPLLVERMMRLCVAFGFAAEAAPGQYLPTAVTKEMVNRTSVGVVESLFCEFLPTVQKTPEYLQVTGYRNPEDPLFAPLQYTNNMKEDGFMWLCQNPEALARFNNFMEGQRADRPHWADWFPVQDRVLADADSNPDRALIVDIGGGRGHDLLGFKKRFPNAPGKLVLEDLPVVIDEVRGAQDLDGANIVPVKYNFFTEQQPVKGARVYYFKNVMHDWSDEKARIILNYVVEAMEPGYSKLIMEEYIVPDQNASAIHGMTDVAVMVFCSGLERTTQQWTRLLDSVGLRVNKFWTRAGDGLGVVEAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKZ4</accession>
    <name>A0A370PKZ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_276403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKZ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="521" mass="57939" checksum="47965BD88EC50AF1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKZ8</accession>
    <name>A0A370PKZ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="233" mass="26350" checksum="ED1A398EE54FCA09" modified="2018-11-07" version="1">MSEQNQNQHQNPNINLTLETIHAPSTTPHKPTSITIFLAGSTPPSPTTTSRDPSSSMRISSFSSMKRDPAHNQQPPPPPPTWRDTFSTHLAHYFLPKPQPHPDSNIITSPPQTVHLTIYDPFRPDWDSSWREDPSFPPFKEQVSWEMEKRERADIVLFYFDPGSAAPISLLELGLCMREPGKVVVVCPRGYWKRGNVEIVCERFGVTVVEGLEEGARVVGRRVERVGREREGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLH4</accession>
    <name>A0A370PLH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_251110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="68"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="386" mass="43643" checksum="86CE345728A80588" modified="2018-11-07" version="1">MLDPFPPPPAWLRDFVEPWALHYNVPALTEHAHEVIIAFAGYLFIHFILSPVLSPVLFPNHYPKLKPRTKLNWDVHVVSLVQSTFINGMALWVMFADEDRASMNASERIYGYTGACGLVSAFAAGYFVYDLIVSTIYVKLFGIGMLFHGISALWVFSFGFRPFVNFYSPVFILYELSSPFLNIHWFLDKVNMTGSNLQWYNGMMLLFTFFSCRLLWGTYQSVAVYRDMWYALKQTWDATAAATPLEPVDITSQVFQVRGGSGSEMAKYASFTAGGVPTWLVLTYVISNVVLNFLNYFWFSKMVETVLKRFRGPAEKSGPAGKPSKEEQISHLKEEITQKVVLEAASKLEQEEGSPFLDGVSEEKVASAVDSGLTEELRKRKVQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLQ1</accession>
    <name>A0A370PLQ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_265987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLQ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="124" mass="14280" checksum="DC203F29F2719924" modified="2018-11-07" version="1">MTDHRHFKITVGPSEGIRLSLEGVTKAKRRGGAIDRHVLYPTGSIECLKAQRITEYIVTNPNSWLSSGVIVTVLETQQMDWLTFRMRNAEVQERCCKPAAETLYFYYGVDLPYSPRFCVRRKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT6</accession>
    <name>A0A370PLT6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease regulatory subunit S10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_276220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLT6"/>
    <dbReference type="SMR" id="A0A370PLT6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="393" mass="44194" checksum="BCD312A506379756" modified="2018-11-07" version="1">MNGASDPEREQALEDYKRSLLELREWEAKLKSLRMGIKDLQREFDISEENIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDKAKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQINFAGIGGLNEQIRELREVIELPLKNPELFQRVGIKPPKGVLLYGPPGTGKTLLARAVASSMETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHSSTVQLDGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAINQDDFNRAVRKVAEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLV4</accession>
    <name>A0A370PLV4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLV4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="130" mass="14765" checksum="44DC894113711D0A" modified="2018-11-07" version="1">MVKTSVLNDALNAINNAEKSGRRQVLIRPSSKVIIKFLSVMQKHGYIGEFEEVDDHRSGKIVIQLNGRLNKCGVINPRYPVQLRDLEKWATQLLPSRQFGYVVLTTSAGIMDHEEARRKHVAGKLLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLX6</accession>
    <name>A0A370PLX6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="78"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="323"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="63044" checksum="EBFF39727F8240BE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM87</accession>
    <name>A0A370PM87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_155593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="16768" checksum="A9BA48D62695388C" modified="2018-11-07" version="1">MDEAAPLQDNHPAPKGRTPVTLRVNSPGCIVRKNGLGSSDAGGGGGRPVKARGRGRQMTRGEHLHGTCSQLAYIDRSSAVRGTFEIIGCRPNITLSRHYSAPNPAAPCLRNLDLFFFFSCPEWTRQITPSAKGCPAEPGGHRTHSSRVPNLRLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP6</accession>
    <name>A0A370PMP6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="34091" checksum="20C029F6C0DE8330" modified="2018-11-07" version="1">MTTRSPNPVALVVGASRGIGRQIAIDLAKNGYTVIIAAKSATSPDTTAPFPPDPNSPASTIHTVAREIALAGGTAHPIQVDVRDPAQVDNLVGETVRITGGRLDVLVYNSGAIWWSSVANTPLKRFQLMQRVNPEGLYATIMAALPVFEKNGWKGRIVVVSPPIYSRFFRGKTAYAMGKVGMSVLTRGLAMDWVREGKSDMAITSIWPATAVESAATEMNPANDGDSRKADLRKPTIFSDAILGILNTPAQTVNGLLALDEDFLRDYCGVTDFSKYSVIPGSSPRRMMPKEMPVLEVAEQDDEGVRMDSSKATGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMQ1</accession>
    <name>A0A370PMQ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_292643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMQ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="189" mass="21981" checksum="EF2F7D7D969A94F6" modified="2018-11-07" version="1">MDTLLYPTLLRDLWPHLDMSHWPTLDRHLYPFYPISLPLSIPVTQHPDPILARRLRLKESGITFEYYKKLFYTPLDNLILITIEFSLDTLLANMPDCDTLAHTPIDRHHPHCIFAILKSAKQHLRRSLRTGKFANKAINQKKYHVLFITLCINAKVKRAKRRNRGGVATSHICNVNPYAICVLSPTYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNL2</accession>
    <name>A0A370PNL2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_313680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNL2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23629" checksum="9618EC77F2F17241" modified="2018-11-07" version="1">MQFRYSTGTYNPFTFPWEAGIPNTPFWDTNTTSTRATAPQQANQRKWPLSSTSLQEKIKHEEARYTLPDNFHNADHTFYRRFWLAVASVSVALGQTDKAEAAYRTLVTNREDKNDLVPVFNLSGFLIHYGTTSKVQEGLGLTGPCLEWLDKKLGRASPQGIEVMGNIAEAEWKMGRREEAEGMIKEAHECIDELKGTKFAVYEDDQGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNM7</accession>
    <name>A0A370PNM7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">M752DRAFT_212318</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="538"/>
        </location>
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            <end position="682"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
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            <end position="735"/>
        </location>
    </feature>
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        <location>
            <begin position="867"/>
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            <end position="226"/>
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            <begin position="235"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43788.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1089" mass="114180" checksum="1F8E7E5EE37FD963" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP97</accession>
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        <recommendedName>
            <fullName evidence="4">Prefoldin subunit</fullName>
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    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1192" mass="133633" checksum="D9E1B1E73DAC63C3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPP2</accession>
    <name>A0A370PPP2_ASPPH</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        </location>
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            <end position="180"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="198" mass="21924" checksum="AE8ABA1D272D27EF" modified="2018-11-07" version="1">MAHAGEEINHGKKRPADSYPEGDQPLAKRFGRLHINTITSEYDINDRRLPASVHPDTMLLDDTKDIIYIHDLDRELEDIEQKDNGLEIFPGVADRMSTIPKLLVANTTSPCNELVLYTEPTSLSIPKEDDNVRKALIATRERARKSRQDFHTQGRDITKSSAASATTSGRGTLEGPIDGCGEPMEIDVDCWGSIPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPW1</accession>
    <name>A0A370PPW1_ASPPH</name>
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        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_334163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="371" mass="39654" checksum="E1881522849583A0" modified="2018-11-07" version="1">MTSTFSFGFAGDDIDIDDTEMNEIDETNNDQNAGAGSTLPELIPAKKHDVAEWIPTLPSQISFNKLRLPINTAAATKHLTLARRDIFDIRAQLMAEDTPDENNEELIAGLEKGDIKPNFYEGGFKTWECAVDLAKVLVDADELGVSTSAGDRHIIELGAGTAIPSLSLFAQLLSNPATTAQGKKTHFTFADYNSAVLRLVTFPNLLLTWLHYTQTSSSPSSEGESEEDELLDITPTLIQSFQEDLSARGITISFISGAWSPAFVDLVFSQQESHSQTLVLASETIYSPASLGAFSETLVALLRRAAATPGQQSGALVAAKKVYFGVGGGVDEFLAVLGGVAGAQGVKVDVQERLDVKSEGVGRVVLGVRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPY2</accession>
    <name>A0A370PPY2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_264169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="144" mass="16000" checksum="3834E25CDF02F6A8" modified="2018-11-07" version="1">MQNHQHIIVRSVDKTKARAWTNKSEDSPSSQSSFWKDNVDGSDPSIHSAKYDIMCESSTGDHACHLVELGKSLDILAEAIHPFDTEHELLCHSSGNRARHGVEKRSEATLQVARWNLIKGITSSDRSSACQVASESRRLTRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQE7</accession>
    <name>A0A370PQE7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_334332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="205" mass="23920" checksum="52ADED8EB1C88C08" modified="2018-11-07" version="1">MSTQTSQIVYHYLDIGRLGRGEVVRLFLKDAGIEFTEVRYPYDDTWPQVSKKLQEQGISRSGLVPALEYKGKILTQHIPILRYLSRDLGRYDGETNWEKYLIDVVADIYIDWRSEWVSNFMQASEKYKNETTAKYYDLVGKYYAESEGPYLLGDKVTYADFAVYQSMDNDRRTGTIVADLPESLVRLRDAFEKRENIAAYIEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQG0</accession>
    <name>A0A370PQG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_139605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQG0"/>
    <dbReference type="SMR" id="A0A370PQG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="222"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="59310" checksum="A91F1F59A1D7E29E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW7</accession>
    <name>A0A370PQW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_142226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="54688" checksum="AADAA7EB272CAE0A" modified="2018-11-07" version="1">MADYLYDLLAPHLASTKAAAALCDPDRDTTTAQYLNRLPTLSLQALQSTEPQSLTQSSHSTLLSLQALSNRSHKAFVTSADGLSNLRASIPQLAQNAQQLRDAVPKLDEEAVRFSSKYSRAAENVALEQRKKVMQLARNVDRLSDILELPTLLATAVSSAAASSTTTGSSVSTTYSTALDLYAHIKRLQTLYPDSPLIKDVVSQAEDAMKDMTSNLIAGLRAQNLRLAAAMRTVGWLRRVAPELDNLHHEGSPAAGEGALGAIFLICRLANLITMLEALDPLRELADQETQRRAPSTDRKNGATGTWSEGHQTEKYLKRYIEIFREQSFAIVSLYKNIFTPDQSESELAVTGLRGIDARIKAAASRPSRPEDPLQCLPPALATFPMHLVQLLTDTLRTYLPNVRDKSSRESLLTQVLYCAASLGRLGGDFGMILTELSEAADEEQEESDADADDLAYEWEEVTRKHRALAGRLEQLTGGTTPGSSTKGHSSRQALPMQGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR54</accession>
    <name>A0A370PR54_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrase/ferredoxin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_248875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32896" checksum="28EADEE6400D14A3" modified="2018-11-07" version="1">MFRSLLSRGGLIRNDSYIFPTVDPTEDGPNCKRDCADCTVQFPSKVKVETSKPLYGHIKEFHTHVLVATGKSDWTEKVENEKGSLMQAFDESAHLSKHGRFMISASNLTTPETDDETNQGTTVLLLPSFTFIDAVKQSDVNEVITRFMDAPLSQNGAIPANPESKLNPRPCEYDYVVLLCSHKRRDARCGITAPLIKKELERHLRPLGLYRDANDERPGGVGIFFVSHVGGHKFSANVLIYRKEQQQMIWLARIRPEHCEGLVKYTLLEGKVVHPETQLRGGFDRARGLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB6</accession>
    <name>A0A370PRB6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="60" mass="6293" checksum="FD71C37E1A7D9F16" modified="2018-11-07" version="1">MGGKKSASCFVSLGRSSQKLSPPLQRGPAGSQESSDYSSPDGKIGQVGWVGWRSPKGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRP3</accession>
    <name>A0A370PRP3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_324855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRP3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016663507" evidence="2">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="26871" checksum="1903353B381BCE04" modified="2018-11-07" version="1">MPKASATKIISLSIFSLLTTASAYTIVGCYSSPGQLTSAGTFQFQSEGYCQQICTKQNKPIFALYNGDECYCGDALPPSTAKVSSTQCQTPCSGFPSDPCGGTNAWLINNSTTISQPTTDNNIVTELKRESTDNVENGIVIAPESDDSDSSSGNSNSPETMTVNPTMVETGIPIAPSSGADGGAAKSTIPSVILTAPSMTGVTVPATGAAAASSMVVVASSASASATAAASGAASSGSAAASPSTSAGAAAAVAGAPAGGMIGGVVMAAIVALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRP8</accession>
    <name>A0A370PRP8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amino acid oxidasesarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRP8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="441" mass="48290" checksum="192AFC80D93B8955" modified="2018-11-07" version="1">MSLPANILIIGGGVFGLSTALSLSHRHPNSQITLLEASPIIPNPHGSSVDSSRIVRADYSQPHYAKLAAEALDLWRNTDWGKEGRYTQNGLLLVYPPGSTNARDYANKSYENVKHIPGQDVELLPTREDVARAAPAYGVNLSVEGGYVNWGSGWSDAEAGVRYTKQRLDQEGKVIFKTGDVSSLQYSNDKSNRVTGVNLADGSSLTADLVILATGAWTAKLVDLRGRTVQTGQAIAYIRISDEEQKRFEHMPTILNFATGIFIIPPRNNMLKIARHAYGYVNPVQVPVPGTAQDEGKRMKVSLPEKGVPIPAEGEKAFREALKELIPSFADRPFAETRICWYTDTPKGDFIITYHPDHPGLFLATGGSGHGYKFLPVLGDKIVDALEGKLEPALQDLWKWPAAVPESEFDGTEDGSRSGPKGMRLMEELLKTRKAKRGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRX1</accession>
    <name>A0A370PRX1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_290982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="35120" checksum="A62B79F53CB120A7" modified="2018-11-07" version="1">MALGTPLMLDPAMLADSSLVHPEDDDDSEYEYEYHPTETETVYLTLDLTSLHGPIRPPRRRQPQDPSSLPTSSPSTPSHSQYHDDQPDAALSSTEADPNNPSIADRVQILGLHTPNPIISYQNQIFSGTWADQIGTELLIARPEDSSSSPPHDADPSSFTSSSNPVPPLRHTPNYDILAANSVKILGRKANLISSSSSNVYAADSAAAEQPSETPTTGVIRKSAPQTNQARFLDRLASLKRSKGETDAVRTTFSTKRMTNLEDRLRGWARTDEQLAQIQRLNELALSGDANAMAELEGLYSRLGGQDDEEELDENEEELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRX7</accession>
    <name>A0A370PRX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_324927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK44948.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38127" checksum="AB5EB267ED13997B" modified="2018-11-07" version="1">MEPEIDPASLFRPGKRRKFQRRRPEDNDEESPSATEDVALISESSTPSSWQEPSPNSVPTADILRSRRLQRARKGGIEFSATSRPPAGKNSQTAVSTVAEEDQENERLRAMCDRFTAHTGQTVDVDKHMMDFIESEMAKRYRRDMPTEIAMHDTPSATEPKAAALSSADLPQREPASLGKLHEIDLGHETTLQNIARTEAATKRLAGDGGQTPPTEQSPGPKMAPANGDQKTWRNRKRRTSEDIERDRLVEEVLRESKLDVYEGPEEEGDEAVGEDGQAADDRVAEQFRRDFLDAIQSRRRVARARNTKTTKPDAPRGPKLGGSRSARAAMREMQEKSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name evidence="3" type="ORF">M752DRAFT_274454</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45187.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62566" checksum="327845C2DD21252A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSV7</accession>
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        <recommendedName>
            <fullName evidence="4">LPXTG-motif cell wall anchor domain protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">M752DRAFT_210741</name>
    </gene>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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            <begin position="576"/>
            <end position="770"/>
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        </location>
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            <begin position="246"/>
            <end position="259"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="748"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45251.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="95207" checksum="4A6460FFA33DA09E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT73</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="32291" checksum="C2BF9AC55BEF0837" modified="2018-11-07" version="1">MSAIGQAEVDRRIAVAMREAKEDTLRLPEAQNSTATQQAGSQPKITKYDKQVATVLDVVRPLEWALENGQPVERRIKSRESITAALLYRRGVEVARCVRCQTKGPFVRLKFEKSKGDMWAEADTQLVLPNGGLRQTLQLIGEDGFDFLRVNDEDSASEAQELGETCALNDSSPAHQSEDTALSGTIHSSEEQSILPTGATNSGSEKEAEVYQAADTSLFDPSANESVLLAEGPWCRLLYSEEMPADDCETLPQSSATQIGEDICSYPPAGDCPLALVLEDAEYSIEHEPQKNKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTD4</accession>
    <name>A0A370PTD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_324389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="811"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133063" checksum="02F1DF3B7CBE07C4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTV2</accession>
    <name>A0A370PTV2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_311740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="559" mass="60320" checksum="C924FEAEF1512DD1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTV6</accession>
    <name>A0A370PTV6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_281810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="383"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="791" mass="87228" checksum="E17B634AF908267A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU42</accession>
    <name>A0A370PU42_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_273867</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU42"/>
    <dbReference type="SMR" id="A0A370PU42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="16">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="155" mass="17046" checksum="060AC8269D1F37EB" modified="2018-11-07" version="1">MDQAKLARMQQSVRIGGKGTPRRKVKKVHKSSGADDKKLQATLKKMNVQPIQAIEEVNMFKEDGNVIHFGAPKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKNQAGADGKKDDEEDDIPDLVEGENFESNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUA2</accession>
    <name>A0A370PUA2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_122689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUA2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="84"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="581" mass="61751" checksum="CF6BB2F5E47F0B8B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW9</accession>
    <name>A0A370PUW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_95831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="11291" checksum="6FB81E295C6BCE38" modified="2018-11-07" version="1">MRAGLVYLPFTFCLLAAFESGETSWWSWVFRCCFLRELCSSIHCSSKCALCGVCAGLAIHTVDFCFFLLCYLFRLVGVVGLCFSRVLTSILIYWNGGVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVR3</accession>
    <name>A0A370PVR3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_100168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVR3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="76" mass="8240" checksum="EFA5E739CC27B863" modified="2018-11-07" version="1">MTMSRGAGARPLAGAHGLRIAYEEVCIKCASRASGTGLTSGWFTDLVFIIMIIWFTTRKEPNGWSSVSVVATHHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVT0</accession>
    <name>A0A370PVT0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="66" mass="7040" checksum="66D0EBE30F70CD57" modified="2018-11-07" version="1">MADVGLRAVCMRDLFSLGRCPNDADWTLDGFLLLFALSTSTGLALGFAPASSCDARRTQSSNVCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWN2</accession>
    <name>A0A370PWN2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_310104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="32241" checksum="5CCEDF76B65570CB" modified="2018-11-07" version="1">MGVAIRSGFEYYYYYPSLAAAVIFIICFLLTTLLHTFQLVRTKTWFFIPFLIGGYFEFVGYCARAVSANQSPNWTMGPFLVNSLLPLVAPALFAASIYMELGRLIIVLHAQQHSLIRVKWLTKIFVTGDVLSFLLQAGGAGLMGSHSKSGTETGSHIIVGGLVVQIVFFGFFIITTAIFHHRMLQSPTPYSLEINWKKLIWVLYSASVLILVRSIYRLIEYIEGFGGYLLSHEVYLYVFDALLMFAVMLIFHVVHPSELNAWLKSGGLVSKGFRFERLNRNAIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWY9</accession>
    <name>A0A370PWY9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWY9"/>
    <dbReference type="Proteomes" id="UP000254937">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="38314" checksum="98696A752529AA6C" modified="2018-11-07" version="1">MKYKSPQVESETDAADAPKRKLDQRDPDISTGEGSLEVEKEQPPTKASKSAANTVEEDDEVQEDSGYKDEEFEEEGEEDNEEFDEEEEYDEADDENVDFVKEQGGEEEEDQDAEGEEDDEGEAKERVSSKPKLQKVVKEFGRPPLYGTEIAEGRLESSPDTLLAMVMDAMLKSRPISHDLTQRAVNKLIEVGYHDIRKLGESSWEERTMVLKDGGYNRYREQGATNLGDLAEFVNEKYDGDLNNLLKKAHNDRDETRKLIKEIKGLGDLGVDLFFNNAQAVWPSIAPFIDGRSLETADNVGLGTDLDAIYADLGRDSMSMSRLANGLSAVRLEKRQGDLMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXZ8</accession>
    <name>A0A370PXZ8_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">DUF1237 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_244834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016612486" description="DUF1237 domain protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58977" checksum="7C5D275FC1979621" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY48</accession>
    <name>A0A370PY48_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_228142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="598" mass="66696" checksum="DD0E669C5F3386E3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYP7</accession>
    <name>A0A370PYP7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_228499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYP7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="206" mass="22423" checksum="B3C9D4F77D4F14C2" modified="2018-11-07" version="1">MSSPFDINGGACVAMVGKDCVAIACDLRLGMQALTVSNNFPKIFNYGPSTFLGLTGLATDVSTVSDLFRYKVNMYRLREERNIAPQTLANLVSSSLYEKRFGPFFVSPVIAGINSTTGKPFICGFDSIGCIDFAKDFIVSGTASEQLFGTCEGLWEPDLSPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ25</accession>
    <name>A0A370PZ25_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_271765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ25"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32270" checksum="FCCB6642071555F4" modified="2018-11-07" version="1">MDSPLLSPAKARQAAIQAKDWAYVNAWLSRQYAPNPVPSFERNEDTLRTLLALAAANDTADEEATVLHQAREQAVESFKIREEGEEKQKVEILDEVEHSLDDNGRRHLDDLAETTAVLGALGTNTKDLGQSIIELTVEEFNAQQQMSKVQALHDYLERELATLREQLLDLKTNEVYETPANLPALTAEWTRETKMLNAKAGEYQDRIASLQRSKSKGPTLAEVIAEEQGVIRMLESTKALVERVQKFHDLPKDVRGAQVQYKELEQELETLTQQRDTMFEKLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD4</accession>
    <name>A0A370PZD4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_288044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10407" checksum="8E1FD870583ECFF0" modified="2018-11-07" version="1">MLHRTSTGAYPDILTSGMRDSEDWRVSPHQMRSTGIRQRIVSKFIAKDARVLVLDIVEPGPEDSQGDFSNNVTYVSGDVTSPEDWQKALELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZW0</accession>
    <name>A0A370PZW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_299641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
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        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
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        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
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        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="96"/>
            <end position="618"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="704" mass="81174" checksum="0A4A8209A734DC32" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q013</accession>
    <name>A0A370Q013_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_272020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0520">NAD</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="38"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="343" mass="37096" checksum="DA5741C303AF10E1" modified="2018-11-07" version="1">MAPPSSPTDHHIVALQGDFIRIPKFELPAPYTHTTKVYGLTSLSELHERIHDASILVLSALRIDAEALSPEVTPYLKLIVIVAAGSDCVDLEACRKRGITVSNCPAANTEAVSEHAIGLYFSVRRRVLRAHTLTRAGEWTRKKTLVFDCVNHDGTQPLTCQEEVAGIIGNGAVGKRIAQLARGLGMKVIIAGRKALGDGSTPTHAGDGEERVSFAEVIKRSTVIFIAVPLAPSTRNLLSATEFEAMSPHAVLVNVSRGGVVDEVALVRALQENRITGAATDVFEKEPAGPENCALLGEGTEDLNLVLTPHIAWATQKTLINYERKLKETVEKWMVGEFMNVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q017</accession>
    <name>A0A370Q017_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_288262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q017"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
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        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="3">
        <location>
            <begin position="572"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="862" mass="93977" checksum="3B606D7F359C1213" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0I2</accession>
    <name>A0A370Q0I2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0I2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF228">
        <property type="entry name" value="P450 MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016761531" evidence="8">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="489" mass="55044" checksum="8B766EAD57679744" modified="2018-11-07" version="1">MLSILLLAILPIIYLVHKYFTDPLSRIPPAHPLSPYTTKWITHHRDRTTEVKAIYTAHRARGPIIRLSPTELNVNSLEGLRAIYTQGAFEKHAFYADTFMNFHTPNMVGMLENKPHGEQKRLLSGVYAKSYLLRSSDVKVLGREMVVGRLGEFLRGVVAKSAVINVLPVFQAVGMDFTSGFVFGMQNGTRFLEDLTSWGVWLGQYEAFKSMSREERFMGFVERWCLGLCEGVGLSKQSGGPVTQAVVYDRLREGLEEKKKVSGEDVDVNLAVASEVLDHLVAGHETTGITITYIMWELSKRPELQTRLRKELASLPGSLRYTEGMEKGLPSLADIDALPFLDAIVRETLRLHAPAPAPLPRVTPPEGTWIHGYYIPGGVQVSSSAYSLHRIEEVFPSPEEWIPWRWMDVKDDKIHDMRRLFYPFGTGGRMCLGSNFALLEIKLVIAMVYANFAPEVVDDEGIGQHLEFIALPKGRKLMVRFVPVEGHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0X9</accession>
    <name>A0A370Q0X9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_272292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0X9"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="211" mass="23667" checksum="E88F656964D69034" modified="2018-11-07" version="1">MATNITYHASALTRTERSDLRSQRGLTIWLTGLSASGKSTLAVELEHQLLRDRGVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSSAIAITSFISPYRKDRDTARQLHEVPTPGEETGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPLKPEVHIKNHEVPVQEAVGQIIKYLDEQGYLPPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1J1</accession>
    <name>A0A370Q1J1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_8455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1J1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="330" mass="34668" checksum="25D205007B5173ED" modified="2018-11-07" version="1">MAATNFSNPDSLDVLTSMVNQTLIETGRFFKTGGSMQSRAQLKRSIPTAHEKFQSALDNLSEQIFIAKAFLERDYEAVQAKKAVLQPVEDVVMNESNVKVESESTSQPSGQPVTDADTVQPKTEPADDTLAPKPQADANASQPSDQPVKVEKPEEDAAAVPAAQPVSASGDFNFDSMLADNSGTNDFDLNLDFGDDGVGNDSFLSGSNLANATSTTNNSNGGEPNQSSNAPTALPGTENTPVPAPMGGDAFDLELQKAEAFTTQGDSSGEQPFDGQGGSNMEDVMAPGESSFDDLFMENDNFGGDGAGDASLLDGDGLVNINDLDDSWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5G4</accession>
    <name>A0A370P5G4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_270999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5G4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="31198" checksum="68914BBAC2DC76EE" modified="2018-11-07" version="1">MMLTAVCRFPLLQRLHFLGIWSASRRPLIEKVAGQLAEDTKIVTDHRKTWKPIIGLQLFDARNPVGIYDPHMRAAIYHEYYLAWTRDLRDLPDPELLATAAPSHLGFLPRDYLHFLGELAWQIYMARYQTGLLLDKLMPPRKDSPGVGVDLYGDAVLNAMNPILKAVGRSAQPGNYSLRDRCQNPQRYDDLLQHCVLHFKECPRCRGYDAMTWQERVPAIGEAYEKKYTDCSCLNIISVYMILTSPDRLWWLADPTAEYTGPQEEWSALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R7</accession>
    <name>A0A370P5R7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_309303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R7"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000108">
        <property type="entry name" value="Octanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="30309" checksum="22CE5C01153F4A3D" modified="2018-11-07" version="1">MRLAHLHLPDITSFTRVANLQQTLTSRLLSHKKHLTPNPPDPTIITFSPNPVYTTGRRDLPPSNTTHSNSNGNGNILSLPPSLEPIRQILTPPQPNKPYDPKSRIAEYHPTLRGGQTTYHGPGQLVAYTILDLRRLGLTPRCHIRLLENSVIDVLREYGVRGMVTEDPGVWLPKKITAVGVHLRRHISSYGIGLNVTEEPMWWFRQIVACGLEGRETTSLQGLGVTGVTVEEVAGMFVGKFVGRVNGDFACGDGATGEGIEEVYRVSEKDLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P643</accession>
    <name>A0A370P643_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_242212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P643"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="329" mass="37239" checksum="94E6CF2EA424A451" modified="2018-11-07" version="1">MDEESRPAACPEPPPLPYSLRSRKKSIAIFWTIFVIDTLAQPLVLYWALWYATDLSHNLVFSIVTASLGGVSVFEYFYRLYNLFRKDSRARPLNARKGWLDFFHINFTIVWLILAVELIVGTVPQEPYVRLVAMVLPTVMFYFGSMYLALDILRVCGVKAPFRISSTPKGSTMPTALYVLIEDVVAVDGGGGQIYRYALRTRYLSSPYFRRMLFQMNCFWAGGSIVVAAAITAIIFTVSEPVAYTLGWSLPFAWAGLWTLVTIPWVQSDLRREKKAWAENRGQGGIPYTDDPDAPSGGRTRLEAMQDHLPSFVPWFREKQAPPSTPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P655</accession>
    <name>A0A370P655_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_339875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P655"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="149"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="28865" checksum="52F6FF20302692FF" modified="2018-11-07" version="1">MAPRGRGKFSKPSRGGGKRFSRDVQPVDKDGNPVGLWRDADEDVPSSIDEDEEDGSTSGSDSDSSEDDTPSSTKPGPSSSIPPTDSAATAAAPELTREERRAAAKAKKQAAQARRLQTAAQPGDLPPSSSDDEDHSEGSDGDDEDLPANPNHTSKSRSQLSSNATGGGASGGGEGKGKDQQDLSQLSRREREAIEAQQARERYLKLHAEGKTEEARADLARLALVREKREAERLRKEVEKEEKAEAAKRRAEELKAKLGAKGGGKKGKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6A3</accession>
    <name>A0A370P6A3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_91480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6A3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720534" evidence="3">
        <location>
            <begin position="22"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="578" mass="63608" checksum="B165E7DF6F9F5176" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6V5</accession>
    <name>A0A370P6V5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_241538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6V5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="179"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="402" mass="44781" checksum="A2DF19CC3C9355B8" modified="2018-11-07" version="1">MAQFDPNLEQIQQCLAEVTAAVDQYRNQATTENSQDARYQLMTQATRLVRAIRGPADLVFANFEDMVRIGAIRTLLEAGVLDAIPTGGQSISASEIAAKTGVDKELIVRHMRALTPTGPFRETGEELYAHTAESEILLPPQMRAVFSLMVDEYSPAMLRAHEYFSQQGWQHRIELRRNPFTFVHGCDGQTMFEHISQSPARATRLNDAMVAEDSLLAEIGLYPFGSTLSPLAQPDIATIVDVGGGRGHILRQLKESLAGIPGRYILQDRESVIADNGPEMESHGIEPMAHDFFNPQPVQGALVYFIRRVLHDWPDEEVRQILAHQADAMDRERSRILITETIIPEIGATATNAYMDLTMMTFGGRERTVKDFAHLFELAGLRLANVYKAPGVPMVVLEARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7L2</accession>
    <name>A0A370P7L2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_339129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7L2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="55709" checksum="4FBAE0BA0BC99503" modified="2018-11-07" version="1">MEAVPESQDYQPTAETPLLQRTSRCDDEEPMTTPHPHLTRVVVIIIICIFLLELGDYMMRAPSIRVLEDITCRKFYGSTTPFNSHVPRPIPEHECKVAPVQAEIAMIKGWDNALSCIPAIFLAIPYGYVGDRYGRKIMLVLAVLGILLSQIWVQFVLYFNDTFDVRWIWAGNLFLLIGGGSAVSQNSIYAIVADVAPEAKRGPIFFQVSAAALISTVVGIPLSWLLMTIDPFNALLAASGFIALGNMLVLFLPETLQQAKKDDAALNHLAQDSHTDQETSPTRAKSSNIDLWVLIVKAVHDSRFILANPGLCALIFTFILSSLSNNSVSILFQLASLRFHWSLADASFLLPFSSVINFVILIGILPVIYSVLGSRFGLRPSSKDLVVARGSLVFHILGALAIAFPAGPSFLIFGTFIFACGDGHVSASRSLLTSFVHPDQVSRLYAVLAIMMTIGSMVMAPLLSKAFSWGLDLGGDRSGIVFLTVAALYLVFGLPLWINKLPSQDEGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N0</accession>
    <name>A0A370P7N0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endo-rhamnogalacturonase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_222803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7N0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF18">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016985611" evidence="10">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK38185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="492" mass="53419" checksum="4C9BB7E8183B691C" modified="2018-11-07" version="1">MRSISFILFSVFAGLAAGQLIGPVGPTTQLEDKDIECNILDYGGVADNETDVATSIETTFTECVLNNPKSRLVIPEGDYLIKRSVVLSNGTNWAFQLDGLITAAYGGNWTVDRELILQGFAGEQIINSTINGEGDGKFLLDVLVIVNAVDFEFYSSNGLGAFQGQGYIYRNLANTDRPRLVRLISPTNASVHDLILVDSPKFHIVFDFAVNLEAYHLTIRGANLGSYDGIDAIGTNYYIHDNEATVTNRDECVSVKSPSHHALVENLVCNQAGSGVSIGSLNVSAEISNIEARNISIIQGNNIAFIKTYPGGSGYVKDVTFENFRSLNSLYGLDINQYWQNTWEPDTGSVTLSNLVFKNFSGSVADGALRPPLYLFASDLTFATNVTVTEFSVWTETGTTVVNKISNIFGTGDDSYGENDGIESLQSGESPYTYTSTYTITASPTNWQAPSTPTWALPSTGYGTASPIPVYTPAPLWRPGGIDYNLHYWGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7R2</accession>
    <name>A0A370P7R2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7R2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="429" mass="48203" checksum="4C8FBCFEEDE8D810" modified="2018-11-07" version="1">MSTAKFRVTEHIIPACYVREYAGSTVDQEDVLHLHIKQYTPRDLPDPVPADAVTIIAAHAVGFPKELYEPLWDGLLVRSAQSNFHIRGIWIADVANMGMSGVLNEDKLSMDCSWMDHPRDLLLMINHFRDQMPRPLVGVGHSFGGTIITNLALMHPRLLTSVILFDPVIQRLPPKMGFGADPPGPVNFALWRDDVWPNRAAAAAAYKKVFKKWDPRCLDIMVQYGFRDLPTALHPDLDDNVDAANPPVTLTTTKYHDVLGQIRERFHARTSDGQAQLDRSTHADVDPSVAVLPVYRPEPPSTFNKLPSLRPSTLFLLGEASYLDLDDLREGIKSCGQGVGGSGGRDKVKEIILPKQGHFFAFEAVGETASHCASWLDKVMREYRVAGREWKEKRQKMAKRDHLVLSEEWHRVIKPPSSFRAAKSRKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7T1</accession>
    <name>A0A370P7T1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_80579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7T1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="7353" checksum="1A6C67DFA4F912F6" modified="2018-11-07" version="1">MYFQVLTELSVGYGSDPISHIVPFWLDVFSIRHTCLWYTFFLVLFPRGSFVSRLLTNSTAYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8C1</accession>
    <name>A0A370P8C1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_78833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8C1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="796" mass="86235" checksum="1B7D0F141725CB23" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8F2</accession>
    <name>A0A370P8F2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_307744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8F2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="255" mass="27279" checksum="97664BA9D42729C9" modified="2018-11-07" version="1">MSLKGKVAIVTGGARGIGAGIVRSLSEQGAKVAFNYVSSSSRKAADALIESLRQNNNEATAVQADITDPNAPKMIIQAALEAFQTDRIDILVNNAGAGDNRPLEEVTMDSYMRLMDVNVRAVIFMTQAILPYIPRGGRIINLSSISSRGGYATQSVYAASKAAVEGLTRVWATELGHKYGVTVNAVNPGPVDTDMYQAAGEVHLKRMEEQNKKVPAGQRCGTVQDIGDIVSFLAEERSRWVTGDVICANGGMLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8P8</accession>
    <name>A0A370P8P8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_76149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8P8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="63946" checksum="F64870CCFEC35394" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8R9</accession>
    <name>A0A370P8R9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_307145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8R9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="30433" checksum="C9420CB8C665B312" modified="2018-11-07" version="1">MDLARRIIETLNGPAEGSKPPLQSYGDRRPPTASDLAVECLNMLNYSILHGRRAGASTRHGSVESRNGCPHDRARSRLFGWILKCISDTHRVQGLDSSCQHTLAMFRKMPTLVVHGYIVCLASYKPTVGFKANKAAPMIPSHPSAFLLMALTRAIQVIFLQRPIGCIEQRVAMDFQLQNPIILRKSTLFPGCWSPVGPFSSISEPDTDPGFVECQLHCALAYAQISEIIRHLRKDESDETILFVVVKMLLTYSGDCNSSCIMRLHLGPNCGLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8X8</accession>
    <name>A0A370P8X8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_329624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="431" mass="47028" checksum="A700FE9C56A517F6" modified="2018-11-07" version="1">MGTPGTLTPMSGVAEIVGSWPNPFFRQSARITIMAVDRSLEVRAVAAVFFALASVTTILRCYVRLAVVKAFGWDDGVMVLALLFYAMFSGCMIGGSLYGTGKHLTELTNHQRTTAMEYWFYCDIGYALASILCKISVSIFILRVTIDRTHQIVVCLVGGIVVIAGLIFFIMVLVQCHPLSYFWNQLSTAYTGPGSCMNMHIIVGGLYAFSASSALFDLTIAILPILLVRKLNMKRDVKVAVAGLLGMACVASIAVFIRIPYIHTLYSVDYLWATTPIAIWSNIETGLGIFAGSMATLRPILRKFNPSTRGNEYTSSPWPSTRNKQRNFSVPLRSLDTSTTRTPPSEFDDRMAIQGHDERLYGTTMYSVETGERVDMDVADGGESGGRVDEYPILPKNGNAINNGGGGDNGIGVKFPGIISVRREVLVTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9K1</accession>
    <name>A0A370P9K1_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Ran-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_74435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9K1"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
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    </dbReference>
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        <property type="entry name" value="Ran-binding"/>
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    </dbReference>
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            <end position="375"/>
        </location>
    </feature>
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        <location>
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            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="583"/>
            <end position="675"/>
        </location>
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        <location>
            <begin position="366"/>
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        </location>
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        <location>
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            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="675" mass="75492" checksum="5279893FEA09F6F7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9N8</accession>
    <name>A0A370P9N8_ASPPH</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_269488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="560" mass="61896" checksum="3F6D71DD4B9D157D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9P4</accession>
    <name>A0A370P9P4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9P4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="53" mass="6306" checksum="44D6D488C938CDAD" modified="2018-11-07" version="1">MASSWMMPLQSANHKVFWDVRKRVQVPQKLHHLKRRMRQSKRKPSGRKPIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA00</accession>
    <name>A0A370PA00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_305534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="575"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2181" mass="241913" checksum="67F62DAE02BF84FB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA50</accession>
    <name>A0A370PA50_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">beta-glucosidase</fullName>
            <ecNumber evidence="12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_256104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="12"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA50"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="13">
        <location>
            <begin position="411"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="846" mass="92436" checksum="3E9D65EB488DFED7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAJ1</accession>
    <name>A0A370PAJ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_306971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="553" mass="60251" checksum="C2FB74ADED5B1259" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAR5</accession>
    <name>A0A370PAR5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_53722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAR5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="170" mass="18749" checksum="3A290788A0E1A6E2" modified="2018-11-07" version="1">MKNLGLWGRRKADLTEVSLLAEIPINLSGWLDPGGGALCSLFLLDGNFAISPDRPRRWSKSARAFRAFRQRFPHISTRQVRDSQPCGWCQAASVWGKQQGLVHFWLPMMTTTLGMGDNIIAQPPLATGVKVDDDHAPGQVSTIDSGQDEAHQCKCKMPHIGANELLQSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBB7</accession>
    <name>A0A370PBB7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_278454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1902"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1344"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2081" mass="229725" checksum="6552EFC43D7D2FE9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBJ8</accession>
    <name>A0A370PBJ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="McDonnell E."/>
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        <source>
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        <source>
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    <sequence length="1320" mass="145237" checksum="48493F20241298CC" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCV1</accession>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
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                <person name="Phatale P."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="3">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="752" mass="84913" checksum="E74CA9C75CDACA07" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD21</accession>
    <name>A0A370PD21_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_255106</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="233"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK40098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="738" mass="83470" checksum="38820F011C162D5A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD32</accession>
    <name>A0A370PD32_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_48492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="13743" checksum="24AA515CEBD25A5F" modified="2018-11-07" version="1">MSNRYEREAEDLYEEENDPSPVSGTFHDNSYAHETQSSLRNQVPVARDQAPYEDPVQPPYSNTDQQLAQDEDEAIDQSNVISGRTRGAKPQTRNQYSEGPDEDDLPDEVLYGNVGTSSTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD41</accession>
    <name>A0A370PD41_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DER1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_255155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD41"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="61608" checksum="11348DB12F99CE1D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDE7</accession>
    <name>A0A370PDE7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_337421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048239">
        <property type="entry name" value="YcaC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041461">
        <property type="entry name" value="C_hydro_YcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="208" mass="23414" checksum="9B56CC756DA6C110" modified="2018-11-07" version="1">MPPKYNRLDIDKCIFLFVDHQAGLIQLVRDFQQHEFQKNVMALAKVAQYYKSPAVLTTSFDTGPNGPIVKEITDYLPDAPLIRRPGQINAMDNEDFANEVKKTGRKQIVISGVLTEICVAFPALSLIEQGYEVFVVTDASGTFAEHTREAAHKRMAGAGCQLLNWAAVAGEIHRDWRRDIEGFGAIWRDHIPGYWCLMQSYEAAQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDL6</accession>
    <name>A0A370PDL6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_320235</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="545"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="971"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112914" checksum="C8D79ADF9AE642CA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDW5</accession>
    <name>A0A370PDW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_218696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="564" mass="60705" checksum="9375FA7E2AC09C54" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE64</accession>
    <name>A0A370PE64_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBP11-like subunits of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_277761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="129" mass="14483" checksum="9B56F82D3E433892" modified="2018-11-07" version="1">MNAPDRYESFVLANGENKVEMEIDTRIPSSAIFTFNKEDHTLGNLIRSRLLQSSHVLFAAYKVPHPLVPNFQLRVQTDGDITPKDAVIAACHELVRDLGILSREFTKEYELRKMVGATAQQQNGVQDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEE2</accession>
    <name>A0A370PEE2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_267623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEE2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="214" mass="23572" checksum="2DD8808D931B6D8D" modified="2018-11-07" version="1">MQPQAEGKGQHERERESPSTSTTPQPPAHPNPDTTPTSTTGRRPTPFPSHLPRPIVPHPAASSRGGRRRTLPPPQPQQLAPPLQHHRRSSPFPSRLPQRTLTSTTTAQTTPPRTRLESIYGAQSYAFWLGRLMTVLNAILYADLFDAPDPVTGIRPPSVFSLTVSRHGYSQRVAALAGSDRGATGRFRRAFMMLEDALYMMRGDLAVLVLGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ9</accession>
    <name>A0A370PEJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_35167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="123" mass="14134" checksum="59386708C3C94D58" modified="2018-11-07" version="1">MSSFWNPTNIPTSSSSHHHKRRWRNKGKQREQDTIPLFGSSTPAPHRQRSSSSRSDDIVLVRRKGSPPWWWLLCTKGTMGITVMRAVRDEHGARRPRGQLVLEPLFEGKVASFFPTKLVDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEW8</accession>
    <name>A0A370PEW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_267792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="163" mass="18443" checksum="858C80341D03F7DC" modified="2018-11-07" version="1">MAVHQKPFSKGPRIQEYARHSMGPFFLRIPRSVDIQATSLARHHQSFYRPCMERKSSLKQKSLRKVLRTFVFVAMPVSISKALPYGLSSFATTIVSKLQAVAGPGAARSWANNRHIQTYMMVRFFCGSQGHVRSLLPSPYHGDLEVKDDRRGGWGNHESKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF36</accession>
    <name>A0A370PF36_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_218260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="161" mass="18273" checksum="BE0F3BCB78B6600D" modified="2018-11-07" version="1" fragment="single">KEKPNFAQTGRLAAESKTVNVNGSSVVLKYHEPPEARKPPAKEPWRFYVFKGQDLLEMVELGIRSCWLMGKEQLVVDFPLEHPSCSKQHAALQFRFVEKRNEFGDRIGRVKPYLIDLESANGTTVNGDAIPAGRYVELRDKDVVQFGLSSREYVLMLPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGC8</accession>
    <name>A0A370PGC8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_236325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="210"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="728" mass="82620" checksum="34C01840735ABC04" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGF7</accession>
    <name>A0A370PGF7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_301668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGF7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016803817" description="Aromatic compound dioxygenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16052" checksum="ACA1835F5F232A1C" modified="2018-11-07" version="1" fragment="single">MKSLLLGPALLLASFIHAHPGPHAQPDPVHLARRGALAKRCSDTVGLMKRNRHAMRRRALSPSEEDGSDTTTYTITADAPKYDFLKNDTCILTPETSTGPYIYPRSQTLRQDIVEDQVGVPFVMDIGLMDIHTCEPLSNALVDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH89</accession>
    <name>A0A370PH89_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016893227" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="16062" checksum="EDE1F9F0D7C510B3" modified="2018-11-07" version="1">MKTTLALSALISSMLAAAAPTSSSFQLVISSNTDNLNGRALISQGDAFIVAPSGEHGINFTGGDGTLGIENGDVVYVGTDGHVDLKSTDSVQSGGLTQGFTTGSDNTLEWAQGNFYACPHQSLYAAGEPTYMIYTSRSGVTLSSTCVQVALREVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHJ9</accession>
    <name>A0A370PHJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_319750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="559"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="680"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121004" checksum="8B9283F135E4869F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHM0</accession>
    <name>A0A370PHM0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_29016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHM0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="99" mass="11291" checksum="FAFE180829845DE3" modified="2018-11-07" version="1">MLARRVLLRPRIPHPGQSIMTKNELLFVIIAACIPRSKPVWDFHIKRKPIGVSNSNSGYDLWSKSSYRLVPDKISAYGGSRCQTNALRKSPMMERIHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHR7</accession>
    <name>A0A370PHR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_216615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22848" checksum="B9E5C95E25884B2E" modified="2018-11-07" version="1">MFRSKKLTGTVSNHVPLTMSSINKAQSVDCRGRDTQRRYAGYLWLEISLTHRLNEKLKTRWLLENEHQLHQALICYRETGPVLEDAPSFSNSFAGTYNSHGVRARIQFLRHRLEKEQELIDEIMQQPKAVRYRRSIRFCHMCIGSAEGVVSMSCGHRICCLCMSGLSSQVDRSSQAPLYECGLCWKIACAVTSHWEQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ21</accession>
    <name>A0A370PJ21_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_300205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="51296" checksum="124DECFA244EF61E" modified="2018-11-07" version="1" fragment="single">MGSIAEASDIPSLTALERIGPKGYVRYIFPFPLGNDYDLEQVVELLRVSYAATTRRLPVMACEAVPDDRTTQRGVLRLQRLPEGDIEPIETRDLRASGAFPTTYTKLQAKAFPVAFFDADVLCRRSVWPTPGERLPVSLLQANFIPGGLLLNWCVLHVVGDGTTYQVWMKVWAEECRRAQGMAIPEPIELSEAIARDRECVMSASGRTAGSLGSHPQYTLLPSAPSGAPPKMLAQNHRTQVFYFSPAALVALKEAASPAHATMTSDQTWISTNDALSALLWRTVMAVQWPLDTLQGDPVSVFNLAIDGRLRTDPPVHPETLGCFLEYLGVSLPIRTILGSASLADLAILIRKEVLRADRQFTDDLVALVEQLEDVDRLVPTAFLDVPGFNCVQTSWINFQLYGLDWGPLLGHRIGAVRAPHIGVINGLQLVLPAPPEGGVEVLVGVEESCLQRLLEDPLWMKYAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ72</accession>
    <name>A0A370PJ72_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="37290" checksum="1D08B710BDD59323" modified="2018-11-07" version="1">MAIAQTQIAAVLPPSGATATSKLQIVHDRPIPSPAEGEVLVKLEYSGVCHSDVHSVRGETPMLTDVAGHEGVGKIVKVGSGLDEQTWMGRRVGIRWLYSSCLECEICAINNTACPYQKNAGANVPGTFQQYVVSPAIHATIIPPELAPDVAAPLLCAGIAMYSSIMKTKTRPGDWIVLPGAGGGLGHMGVQIAAKKGLKVIAIDSGEKKKQLCLSLGANTFLDYKTDDVEREVKALTSGLGAHAVICTANNEPAYTQSMKMLRSLGVLVCVGIPSVPFRLPATPFEMIVKGLTIVGNSAGTAKEMEELMEMAVRGDVTAHIECFEFDCIDDVLQRLGRSEVEGRAVVRIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJA2</accession>
    <name>A0A370PJA2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysophospholipase</fullName>
            <ecNumber evidence="3 11">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_326900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJA2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="47"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="621" mass="67120" checksum="8FEAD4FB3F78449D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK32</accession>
    <name>A0A370PK32_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_17526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="72486" checksum="04F258AF5B8660E3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL60</accession>
    <name>A0A370PL60_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="601"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="739" mass="80189" checksum="7F5F6E9F56566413" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN9</accession>
    <name>A0A370PLN9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_265968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="11025" checksum="17CC9AD7691A0924" modified="2018-11-07" version="1">MSTAELACSYAALILADDGIEVTADKLQTLLSAAKVPEVEPIWTSIFAKALEGKDIKELLTNVGSAGPAAPAAAAGGAAAPAEAAAAEEKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM25</accession>
    <name>A0A370PM25_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_318637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM25"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK43245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20914" checksum="5226798E6D950CEC" modified="2018-11-07" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKQIMNEDVTTVSPTLGFIIKTIDFQGYRLNIWDVGGQKTLRSYWKNYFEKTDTLIWVVDATDRLRVDDCRDELAGLLLEERLMGASLLIFLNKSEVEGCMNENEVRERLGLDSIKTHKWTILPCSAMTGKNLHEGLEWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM55</accession>
    <name>A0A370PM55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_326711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="30121" checksum="821A6274CB2E16FD" modified="2018-11-07" version="1">MELTLRITYHSSAKWAAIASHRDDMPFIGIITSLTIHPVWVPGLRSTPADFISEDEEEFLLRKITTAPLPRWTHLAHRRLQTWPSALTKSNALISSPLPSWLVSPIITPRFDSLGLFADAPHHAPNHVLVNEYRPGQGIMPHEDGAAYYPLVATVSLGAPIVLDLYERSEDGKGSGHGRRPVYRILQERRSLLVTTKSIYTDFLHGISETTRDEGLGAESICNWDLLREPDRYECGWLERETRISLTYRDVLKVASLGNTMKFLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PML7</accession>
    <name>A0A370PML7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_314658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PML7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="178"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="347" mass="41090" checksum="5A38925690C3FE04" modified="2018-11-07" version="1">MTSAGNPKDSMKSTWRTGNRDEWGFSHWLLELLNVHPIALDQEVPVHSKQEKLPYMPQWSLNIWVLFYASIPLVINQVYISYMGHNLGPFALFNLYFFWFNATVIYQVKLLRRLGHTYGFLDGDQHERDGIPDVGVGKVTASLYKTTGSRLVMAIYLSYYNQSPMAMNWAWLPLMIGLYGIVLDFWFYWYHRIMHDVSFLWKYHRTHHLTKHPNPLLAAYADHEQEFFDMVGVPFMTYMSLRLMGLPMGFYEWWICHQYVAFAEVFGHSGLRVHMTVPSTLSWLLQWLNAEIVIEDHDLHHRKGWRKSHNYGKQTRLWDRIFGTCHERIESVESNVDYTKSVHMPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMU9</accession>
    <name>A0A370PMU9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_283201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMU9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="108085" checksum="AC7D7CFBD8BC77E9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN80</accession>
    <name>A0A370PN80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_160112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000014">
        <property type="entry name" value="DNA repair protein Rad1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="376" mass="39923" checksum="265989CD52AF8215" modified="2018-11-07" version="1">MTDTEPIFTAVSSNAHHLYTLLQCIGFAPRATVQITPDGIRFSAEEMRVIQGLAFLDKALFTSYTFNPPAAPNQGTTTDDNDNDSTSDPSTYYPCFVVSLSALLETLKIFGTNDSSTNPNAGRASSVQPTHPSGPGAFSAPSLLLDRSCTIRYTSEGSPLSITLSETGVKTTCELTTYETEGSEVDIPLQRDAIIMKIIMRSAWLHNAVAELAATSPSVLKISASATHEPFFALSGTGGSFSESSVEFSVENGGANGQGGDARGSIDEGSRAKKAKLAPTVTETFLVSPPSSMGSRLKQNYKFALIQKAARAMAVANKVSIRGDRQGVLSLQFMIEFDANGAGGVRPLKGGPPPVVTFVDFRFVPLLNDEDGDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNR8</accession>
    <name>A0A370PNR8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase complex subunit Sds3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_318397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56096" checksum="729BA1B39EBB49F8" modified="2018-11-07" version="1">MAYSPGPTSPVHRNGAPMMANNLQSRGRSTSPPTSVPLSKRDKRRSALQERLHDLTASFSQNRDTQFRQQLHALQCDMTLINNADPYEPGPLPDSAEDIARLIENTVGGGKFAKEMASLAGMWYSRFVQEVNQVKAEKDADLAMLVHRHNHNLERFKQEYAFRVHFAEEEYNNLSLTLRERLVQTISGKRARLMREKEQLDLADTNALLLHPNQFSITNPASPGGIHGNRKTRHTRHRVDLDELGNGIMSEHFNKRKRKAADEDVGSPVRETNPAERAKAQAAAQQQAPSYSINSLFTERELGAHANAAHIATVHFFSTSKRADQPSGAATNGNNTDADDGSGVDGTGAEDNGTPAADMARTASQNFHATRSTRTHGNHALNALAELSDKPAVRPSLPYNILANYHARSSNSGAPPLPPLMNEEVDDDWARIDRLHNKPAGFVDRTLVQLLVETIPSDVDGVPQDPNRFNMLHPDFPTEMGMHLYPLRKDNGEVTSNERSTKKTKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP29</accession>
    <name>A0A370PP29_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_147887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="119" mass="13136" checksum="C9F97B1672359717" modified="2018-11-07" version="1">MRMIPCCERVGTLRSVLDWTPLQFVSKSCPSSTDSSLHWDPRQLPQPLQICACAVPTPYRSAHHLLSHFGATLALEGLQMDEVILQPPIIGELCGLEMIPSAQTSNPFHLDSIGQNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPF3</accession>
    <name>A0A370PPF3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_318521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="90"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="264"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="670" mass="73915" checksum="5F6049CFB58A49F2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQG6</accession>
    <name>A0A370PQG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_325414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="391" mass="43412" checksum="AECE7FF88B604459" modified="2018-11-07" version="1">MGEKEDLQPWATATTVSVTVLAFVCVVLRVISRLERKQKLWWDDWMIIFSMLWNFIVVGFIFGMIHEGMGIHADKLPTSQIILIAKYLVVAEILYVFNLVWTKLSILLMYYRIFRFPYFKKWAYAIGTFVILWVICITFLFIFICVPVQKLWYPSLPGHCISQVGTWIANATSTIATDLIILFLPLPQVWKLQLRLSEKIALTVAFGLGFFVIFASAYRFTVLFSYTSADSSYTLAPTVGWTAIEMSAGIVSACLPTLRPALQLAARKLGLRSALVPALFRSRTSPLSKSDDSQMPADSTASTAGMAARANRHSFYHLPDEEGGVGVTQKQIKLDAVLRPKHDRGLTVTNIRGSRGASGLVGGGTGLGNGEEGDEVPLHGIMVSKDFRQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR11</accession>
    <name>A0A370PR11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_291782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="583"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107743" checksum="0C84C84A85DE8AB7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRF9</accession>
    <name>A0A370PRF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_127354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="44456" checksum="EB813F716A0A406C" modified="2018-11-07" version="1">MTPTHMPFPLSVRTQHDADTRAPPLLVVPGLTPPVTPTVDDESLSGSVATLHSEASSPFLSPIEGKLKDVDAEDRTVSTSDSFTDELEYHTDPRGRPVEFGRGLWSVVYKATPCESSKPYLLTPPSSPAVKARTVAVKSPARRDAHSILDAEALALTRVSRVAGSQNHVVPFKGYIADSHSIVMSAVPLALSTYIEEQAAVALQNKTTRTMFEPIQGMTQWHDLARKLITGLCWLHDGPQMVHGDIKPHNILLRACSSGDDLESDHFPYEPLFADFSSAHPISNPSSPESSLGTALTALTPPFTAPELLCVSSLKSPDVAPTPESDVFSLAVTLLAAATGDLLLYPGANHFQRLAMAREGHRVIEFARSGPNGSRIPRNGIVELIIKPAIVKDPSQRIKPADWVNLVESISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRL0</accession>
    <name>A0A370PRL0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_312562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63523" checksum="22A0F275BD9C4542" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRT9</accession>
    <name>A0A370PRT9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_274200</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="42"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK44909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="409" mass="47630" checksum="62DA0D7D46F27FD8" modified="2018-11-07" version="1">MGNSVPDLDAVGIKADPDLADQFRREVASLLGRNNLNFPGAQPVSFSTRHLTELQREDYYVCEKTDGIRCLMYFARGEPDSDTPEIHYLIDRKNDYRYVPGLHFPLPDDDTFQRFHVDTLVDGELVNDTYEDGTQQLKYLVFDCLVLDGQSLMHRTLDKRLAYFKEKVLKPYNALYDRFPEEKQHRIFAVEDKSTQFSYGIEMMFRDIIPKVKKIHGNDGLIFTCRSTPYRIGTDEHILKWKPPSENTIDFRMRLEFPLLEPDSDDEAEGVTEPYYDYDALPIFHLFVMLNSNEYRPFGEMYVSPEEWENMKALQQPLDDAIVECAQDEQGRWRFHRIRDDKADANHISTVEKVLESIQDRVTEEDLIRVAPAIKTAWKKRQAQMSERGRPGSTAQVNGSNGVKRKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRW2</accession>
    <name>A0A370PRW2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_274224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRW2"/>
    <dbReference type="SMR" id="A0A370PRW2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484606" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="56138" checksum="01F8AB7914022256" modified="2018-11-07" version="1">MRPFTALAALCGLFLSSNSLVYADSAPSSSPVALPRDFKPPQVFKNANLVRNTNLEKGYLRETVNVVVENVDKKPQSDYYLSFPSDLYDKVGALEVRDKSAPEQGRFEVEATEFDSSRDFQYFVVHLPKPLAPSSQITLGISYSALNTLKPRPAAISQNDRQYLAYAFSAYAPSAYTTTTQKTKIKFPSTNVPDYTSTDLTSGADPERQGATYTYGPYADVAPETTYPASVRYEFTKPVITATLLERDLEVSHWGGNLATEERYWLRNNGSKLTDNFNRVEWTISSYQQLPSSAIRELKIPLKPGSVDPYFTDDIGNVSTSRYRPGKVPNRDASLELRPRFPIFGGWNYSFRIGWNNDLSAFLRKAVTGADSYVLKVPFIEGPKVSEGIQYEKAVVRIILPEGARNVRYELLEKATSNGLPGANQIQTELTSHKTFMDTLGRTALTLTVEELTDEARDSQIVVTYDYSLWDGLRKPVTITAGLFTVFVAAWAIGNIDVSIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS45</accession>
    <name>A0A370PS45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_230151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="96"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="626" mass="67614" checksum="7AD735677207CD5D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSI1</accession>
    <name>A0A370PSI1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSI1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="265" mass="29857" checksum="CEDB240E0C96DEE4" modified="2018-11-07" version="1">MASLFTETTPSRIKDTKGLHLLTTSTPNGKKVQILLEELKDIYGLRWTTSLIDLDTDEQKQPWFLAFNPNGKIPLLIDNNSSSNSDPIPVMESAAELLYLVETYDPDHHFHFSSAIHRSQLLQWLIFWSASGQPQQAGLNHFARFAAVEVPYAVERFKAETLRIYSVLELHLSNGLAGGGGGGDETREYLVGEGRGKYSIADINAYAWVRAWKRMTITEEEMDGFPLLRKWIERIGERPAVVRGVGDGYDEEVHPELLLTAKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSL1</accession>
    <name>A0A370PSL1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_274394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSL1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="160" mass="18403" checksum="EDF7166E7BD68DA5" modified="2018-11-07" version="1">MATELTVQSERAFQKQPHIFVNPKAQAKSKKVGTGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTGLVSIRGRILTGRVVSTKMHRTIVIRREYLHYVPKYNRYEKRHKNLAAHVSPAFRVEEGDWVTVGQCRPLSKTVRFNVLRVLPRTGKAVKAFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSZ2</accession>
    <name>A0A370PSZ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_117714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSZ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
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            <dbReference type="SMART" id="SM01416"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45317.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="190" mass="22420" checksum="C625151A835D8F86" modified="2018-11-07" version="1">MVNLRTQKRLAASVVGCGKRKIWLDPNEMNEISNANSRQTIRKLVSDGLIIRKPVTMHSRSRARELAAARRIGRHRGLGKRKGTKEARMPSQILWMRRMRILRRLLVRYRASGKIDKHLYHELYHLSKGNTFKHKRSLIEHIQKAKAERHRERVLKEEMDAKRAKNKALRERRLERKEAKQNALIAEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="570" mass="64373" checksum="AE65D07E7D1D1015" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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            <begin position="130"/>
            <end position="145"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45204.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="821" mass="90282" checksum="7BA049F1C93A69A4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTX2</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Theobald S."/>
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                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20997" checksum="C391047737824604" modified="2018-11-07" version="1">MLLRAVNEARREHHKAICLAETDRQYRDILDDTIGIIFLGTPHQGSDIPQFGAMIARLTWVFGSSTMLLKGLYRDNPHLSDLQERFMSVIRRRRDIKLVAMYERLHTYFAQLIYLGFIVERNAAMLDVAENFAVEKDHMGLNKCASRNDPAYDAICQGINAIRNHAESRGLKRKYLEWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU60</accession>
    <name>A0A370PU60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_210041</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="571" mass="62981" checksum="9415AED4E73DFFED" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU89</accession>
    <name>A0A370PU89_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_273910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF30">
        <property type="entry name" value="PEROXIREDOXIN PRXA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="168" mass="18586" checksum="12F50D67833A9E0C" modified="2018-11-07" version="1">MSGLNPGDSFPADVTFSYIPWSEEKGEITACGIPINYYASKEWADKKVILFALPGAFTPVCSARHVPEYLEKLPEIRAKGVDVVAVLAYNDAYVMSAWGKANQVTNDDILFLSDPEAKFSKSIGWADEEGRTGRYAIIIDHGKVTYAKREPAKNHLEFSSAETVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUM0</accession>
    <name>A0A370PUM0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_312091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUM0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="40"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="59036" checksum="0C67C54080ADA66A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW8</accession>
    <name>A0A370PUW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_289508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="34006" checksum="30118D87DFB5CCCA" modified="2018-11-07" version="1">MRCYGRRLCAIIARLLDHAKIPNVLWNEYMLSYYGAFMQEPHDISFIVPNRLIDAAYRTLQAAGFTACPESDVDACERFQCPEDGMIPARHFHIESYWIVPARTYYLKLYGHAETLFSFPEPTLNEPSRDDKYYMSTRDESIPIQIGPLHDETLMLYVELNKRASADPYGLERYKIKLPNLTMLIHALILLRCRDEGYNSHCDDDWYRMLSSIRWYVIERGKMQIDSLEAVIQLIWDKLEIQYGNLWIRALRKKLRREGVLPHPFVDRACRCFRELDEWPSLLFHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV60</accession>
    <name>A0A370PV60_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_96869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="38291" checksum="AAB00B25DEA1E921" modified="2018-11-07" version="1">MDSLHSLVARDATPACETGNGYDGRMGLRISSIFVILIGSTCGALFPVMARSFKDSKIAKCAFFIAKYFGSGVIIATAFIHLLAPAEEALTDDCLTGPITEYSWVEGIVLMTIVVLFFVELMVMRFARFGHGHSHDEDDDHHVKIEHAATSSPAESVDMKTHMPGEDHLGHSREHHDMELGKQHSDLEEYVAQLTSIFILEFGIIFHSVFIGLTLAVTGSEFVTLYVVLVFHQTFEGLGLGSRLATVPWPRSKRWTPYFLGLGYGISTPIAIAIGLGVRDSYASDGATTLIVSGVFDSISAGILIYTALVELLAHEFMFSTSMRKAPIQVVLAAFGLLCLGALLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV68</accession>
    <name>A0A370PV68_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_323863</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV68"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810971" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="28"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="712"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="1011"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="585"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK46088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128076" checksum="996520A3A9B3097F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVC0</accession>
    <name>A0A370PVC0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_273230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117872" checksum="D2F698F3591AAA32" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVD4</accession>
    <name>A0A370PVD4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_273261</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="448" mass="50220" checksum="255604BD521B72DE" modified="2018-11-07" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQADGYLTEERKKDDPDHGFSTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGTYRSLFHPENMITGKEDASNNYARGHYTVGKEMIDQVLDKVRRVADNCAGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISADKASHESNSVSEITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQQVPNGDLANLKRAVCMLSNTTAISEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEEEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW06</accession>
    <name>A0A370PW06_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_324086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="853"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="694"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1229" mass="139715" checksum="61352CAD26897B82" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW52</accession>
    <name>A0A370PW52_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_102607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="16054" checksum="A87FF0679041F707" modified="2018-11-07" version="1">MPDCPSHGLRTFCQTPHEHRSHFRAQTLLAWLKNSPDFLGSWTPTLTSPRRHLMNYNSSNRAENPNDYHVESRYLSGGKHHEFRIPPSTPLGAPAIRRKRSTLHSRLRFTGFGHACLVPCLNFLLYYGCSILLMRGVNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWI1</accession>
    <name>A0A370PWI1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_310084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWI1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="358"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="667" mass="73690" checksum="79A79E2239286A97" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWL7</accession>
    <name>A0A370PWL7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_246450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1722" mass="192147" checksum="88D46DF901A222D8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWN3</accession>
    <name>A0A370PWN3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_104160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWN3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="67" mass="7633" checksum="0E391AA315FB3483" modified="2018-11-07" version="1">MERVYIQVLAVLDSSLTMSMSLWLAGYYRGTTFSALPPYTGHIPRIFRSCCETSPIPSTTRYFHPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWY1</accession>
    <name>A0A370PWY1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_227518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWY1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="319" mass="34580" checksum="9CA0B66D3F01B15C" modified="2018-11-07" version="1">MVVTPRYSVEMGGGVTAVFHARKLWESGVALSGATSAVRPAAGEEGMYSPKLHGLKLFSSPVIPRTKASIENSSALSPMLCTPSGPWTFVPVRYRSVASCSSSAIYLPWLSFIAAVVQRGLTPAHAGELILEASVATQESATGLGYADGRIVCEKILELAAVTYSDELEIAIVRGGPIVGSRATGIWITKEVVPVMLRSSLSLRKLPRLRGTSSWMPVDDAAAVFCEIPLAPHQLAPAYRMENASVRHGVIYWTPWGLYPALKLKAFFARLFEPAVCRHVILATGRSRACSLTLRQMQAVEDKVVLKLVQHWKDIGYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWY8</accession>
    <name>A0A370PWY8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_323224</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016934857" evidence="14">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="42199" checksum="BA0FF89FF4E55FE9" modified="2018-11-07" version="1">MTLYRNLLLLASLGLSYAAPSKVQRAPDSSLHARAVCTPTAGGDSSTDDVPAITEALSSCGNGGTIVFPEGSTYYLNSVLDLGNCSNCDIQVEGLLKFASDTDYWSGRTAMISVSDVDGLKLRSLTGSGVIDGNGQDAWDLFASDSSYSRPTLLYITGGSNLEISGLRQKNPPNVFNSVKGGATNVVFSNLKMDANSKSDNPPKNTDGFDIGESTYVTITEVTVVNDDDCVAFKPSSNYVTVDTISCTGSHGISVGSLGKSSDDSVKNIYVTGATMINSTKAAGIKTYPSGGDHGTSTVSNVTFTDFTVDNSDYAFQIQSCYGEDDDYCEENPGNAKLTDIVVSSFSGTTSDKYDPVVANIDCGADGTCDISISGFDVKAPSGKSEVLCANTPSDLGVTCTSGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL1</accession>
    <name>A0A370PXL1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXL1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="20302" checksum="EEA3D72681A9DCD6" modified="2018-11-07" version="1">MSVSPRASKEEFMAALGLSTQDPQHEQYYRAMRDEAISTYNHLNEDPSNLLDIYRTTKPPYFWHHIRPERQRWGINEIARNASPLTRPLFARGMTSGEYGPNWVAGWLLYSVFRSRDVRNNRNRRLKDKNGNSGSGGSGEGRASSPQMGLRYDGGASAAASAGGGSGAANSGKKEYYDPVRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY60</accession>
    <name>A0A370PY60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_272874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY60"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="49752" checksum="C591A4D0629A11CC" modified="2018-11-07" version="1">MASNGTNGTNGHNGVSSYHASTTQEAIQAEKDFAAHNYHPLPIVFARAQGTTVWDPEGRQYLDFLSAYSAVNQGHCHPKLVAALVDQASRLTLSSRAFYNDVFPRFAEFVTKYFGFDMVLPMNTGAEAVETGIKIARKWGYKVKGIPENQAVVLSAENNFHGRTFAAISLSSDPESRENYGPYLPGIGCTIPGTDKPIAYNDKAALREAFEKAGPNLAAFLVEPIQGEAGIVVPDEDYLQEARALCDKHNVLLICDEIQTGIARTGKLLCHEWSGIKPDMVLLGKAISGGMYPVSCVLGRKDVMLTIEPGTHGSTYGGNPLACAVAIRALEVVQEENMVERAEKLGHVFRDGLQAIKSPIIQTVRGKGLLNAIVIDESKTNGHSAWDLCMLLKTKGLLAKPTHENIIRLAPPLVITDDEVQKALDIIKEAVNELPTLTGAAEDEVIPPPEKKVKVSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYB5</accession>
    <name>A0A370PYB5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_228271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYB5"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="13">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="407" mass="45141" checksum="D087E57E82FDD167" modified="2018-11-07" version="1">MTASVFQLKCGIKNDPWGKKGKDSLAGVLCSKTPGALELENDQHYSEMWMGTYPTVPSRILATGELLSEYLQKHPEVTGEGYKKWGAEVPFLPKILSFQKALPLQIHPDKTLAEQLHKSNPDKYSDPNHKPEIAIALSNFELFVGFKPLHEIENLFKLAPLQRFLPTETNAPTFDDSLLREISRILLTLPPLLVSETISSLLTIPEAQFGPNQRYIPGLLTRLKKMYPETDNGSLVATILMNYMTLGPGEAVCVPADSMHAYLTGDIMECMARSDNVINTGFCPKAESDDVDLFTGALSFKPHDVESALLRTKKSDVGGCWKTEVYEPPFSEFSVLGVRLGKGEKEVHRGIGGVSLLVVVRGNGWMEVKGEEKKFELREGWVYFVGAGVEVSFETEGGLLVYRPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYC2</accession>
    <name>A0A370PYC2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_71140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="144" mass="15275" checksum="85BB42D4CDD22559" modified="2018-11-07" version="1">MRSSRPGASRASQKQRRRVVSEGGVTVIVTASAATPAAARMPVHWRLVAGSCRQAVDVMRRDGRRLAASADLLAGSGACSRLRIGPERLPACPSHPPALISIPAHLGSLLANGSVNPSCADRPNLLALREEFCCRCWDVDTLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYC4</accession>
    <name>A0A370PYC4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_71188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="28745" checksum="F0A44105FAC02763" modified="2018-11-07" version="1">MTAIIQKLRRKRKLSSELHSRWGDVSITYPNGGSWSQWDQSSTGATSASPDHQRRHGSLELNRSATAPRLGSYSRIGDANVRAPSVDSAMTIPTGHYDARVSRMRRKNQQQSPPIGLSQALDSPRECDHASCSDESSGDEDDVAVPAPLNVSRDRNPAEKEEADAYSHASKSPPLSVTSRMRSRHSAQSHTMEPPMSGPGTAGSKHTSYTSSVPSNPSDDQRPQGHRLSTQHDRKSIRRPKPEPLSLPTQPEMVPSYDELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYG9</accession>
    <name>A0A370PYG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial hypoxia responsive domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_228353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="177" mass="20454" checksum="77FD8EA767EE2C15" modified="2018-11-07" version="1">MSEPLPSSFEEHPQFQEETSLQKFRRRLKEEPLIPLGCAATSYALYRAYRSMKAGDSVEMNKMFRARIYAQFFTLIAVVAGGMYYGSERKQRREFEQMVEARKSQEKRDAWLRELEIRDKEDRGWRERHAAIEAAANEAANAKKSFPEQDAARSAIEPSEQKSIGVLSAVKELLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYK3</accession>
    <name>A0A370PYK3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_323430</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYK3"/>
    <dbReference type="SMR" id="A0A370PYK3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="158"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="35192" checksum="1F0DBEDDB19E8AC6" modified="2018-11-07" version="1">MASLTLVVQPRGKPIKKLPKEVQVSSNASTAEIYNKLAEASGFSIHRLRITKGSDRTVVPNSKDSTVDGIGLKEKSVLHIKDLGPQLGWRTVYIIEYLGPLFIPALFLFPLRPYVYFNFDKPLPDPSQFQLLVCALLTIHFIKREYETVFVHRFSNATMPARNIVKNSGHYWVLAGLNIAYWVFRPDSPAATIQDSFLLYSGLALFIFGELANLNAHLVLRDLRRPGTTERGIPSGFGFNVVTCPNYFFEVVSWVGIYLLSGMSWSVLFFIVVGTVQMALWAKKKERRYRKEFGDKYKRKRYVILPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYT9</accession>
    <name>A0A370PYT9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_289454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="313" mass="34309" checksum="A5DCA69AAF2CBD19" modified="2018-11-07" version="1">MNSLVATPPVPPHHFYEYSRPSPSRPMSTPIHTPNNRKRKADDENDHDGRMSASPTNSPALTPRTLPVNRNIKRARPNVSGRPLALPRLLETLDTDALRGILRTVCERHPGLVDEVVHTAPRPSVASALQVLRHYESALQSSFPLGGNSESDYAYNRVRQPLGNLLDALSDFTPHFLPPHETQSSVSLSYLDGATDIIHALPRWSTPQNNLERDSAYDEICKAWILVIREAAKRGGGIQLQYGGWDQKLAKHNHNSGGKLQAAVNELGSSLGWMHRPDAQGYGSPGGNDLGSIREQLLSGTYGLGTPVKVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZQ5</accession>
    <name>A0A370PZQ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="11" type="ORF">M752DRAFT_271926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="323" mass="34976" checksum="0365D47E237F6DE0" modified="2018-11-07" version="1">MNVEFQGTLSNLENKLNVLISSLTTSPTAAGAPAAAIGLLDADDSLTSAVETLRQHQQNYAKILRLREEAQELEDKVKSIVREVMAYEREITTTCGDESDSDLDSEDDYSDYDSDENMHGEKPTSTGLRGIKEVDYKLLLDFARRISKYNHQAAADAAATAEAKSRERLQETKGPDTEMTGTNGNQDTEAAEPVASVTKDATSWLDESAKMTRQAYMLPYPMEDRIRMGLMAQIQLAAAEGRPGFEPEKEVERLIREAEGVGIADAMPQVDVGEEARHADEAAKAAAHAGSAATSGSGMGAASLPKPKATLDLDLYDPDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZR7</accession>
    <name>A0A370PZR7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentachlorophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_331471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="497"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="60839" checksum="E8C5BB926057BA40" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q076</accession>
    <name>A0A370Q076_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_288309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q076"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="40798" checksum="441CD11FD8E5C978" modified="2018-11-07" version="1">MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGSYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARNEYHVQTVFMQPAQIEGDNLPPEVGNAIGALWRDSGVQECFKRSREYQLNDSAKYYFDAIDRIAQPDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0U3</accession>
    <name>A0A370Q0U3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_227071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0U3"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin conjugating enzyme E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK48058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="450" mass="48741" checksum="ACA676EC3D53212A" modified="2018-11-07" version="1">MVSSLRRLAADHAALHEELPPNYLFPSDDASAGDDLTQLTTLLAGPQGTPYSQGLWRLHLKMPEDYPKSPPKATFRTRIWHPNVEESTGAVCVDTLKRDWKPNLTLKDVLITISCLLIYPNPDSALNSAAGALLQENYDAFARQAKLMTSIHAPVPSELASAVSEAKTRGEDADTVIPEEQIPSRSLRPRKGARIASVTMKKRTTRRSAEESSSSRAYSHQPSTPIEQEAQQPEEPHDTLTLDTTVSDSESETSTNASKENDPSLSPSPVRLAPPSIRKNAFGKRPLSVLTMPMDVDDPFAMGTEETTIDGMSASEKNIAANHPSDLPERGHSPQRKSPKLSVLDKGINSSGRIREDVQIFEDDPDPAELGFIRRASGDGKENPRALAGLKDTDPAIRTSNPSNPPTILAPSASRSVSSGSGLSKPIFGSRKVSSSNGKKAKPRIGIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0W6</accession>
    <name>A0A370Q0W6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_5271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0W6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="467"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="724" mass="72782" checksum="855D9DE155573936" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1C4</accession>
    <name>A0A370Q1C4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_331921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1C4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="57971" checksum="83DBC6FDBB79CC35" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1Q1</accession>
    <name>A0A370Q1Q1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin class II heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_288510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2068"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1869"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1944"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2076"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2101"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2160"/>
            <end position="2176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2206" mass="242772" checksum="FF9BC4CCB8BA42A3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3L1</accession>
    <name>A0A370P3L1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_243442</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851881">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3L1"/>
    <dbReference type="SMR" id="A0A370P3L1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="15 16" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="19">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK36453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="134" mass="14149" checksum="811DE8611248D96E" modified="2018-11-07" version="1">MTGGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTPKSGKGPGSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Z3</accession>
    <name>A0A370P3Z3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF396-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_280407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Z3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="235" mass="26281" checksum="A48AF0FE2EE6CF61" modified="2018-11-07" version="1">MWILPLVGYLGVIVGFAFLTLAIASGLYYLSELVEEHTVLARRLLYRLIYSIIAVQILLYVFDRFPFSLTALSIGSHIVYASNLRRFPIVKLSDPLFILSCGLVGLNHWLWFRHFSQPLPSSRGATSWRQPYQINVEDMPTFTEVTSYFGLCVWLVPFALFVSLSAGDNVLPTMGSEYATGDRVPTSGFTPGTFSSDGKSKNKGMAKALVDGVRDWVKDNGELMGFWKGERAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P580</accession>
    <name>A0A370P580_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_271137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000014">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143482" checksum="BE7367ED26ED11E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Z3</accession>
    <name>A0A370P6Z3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">L-ornithine-N5-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_308510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Z3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK37642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="542" mass="61635" checksum="D672A940F1864169" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P717</accession>
    <name>A0A370P717_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_279508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P717"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="26474" checksum="81AF01A40A4E1692" modified="2018-11-07" version="1">MSSQVCHGMHNGVIQNIQADLPCGVTNSSHPYVTCCVNGDYCLSNSICVNTNNENGNYYYAADCTDETLTDPACGTRCGGRNSAEIVYTSAGYWACCENSAGTVNCSDPSEEIFPGVAPSKLATIQYLPSTASGTPTYAVASSTSTSDSSASNTTTTSSSSSSSTGSSSSGSSGIGAGAAAGIGVGAAAGLVIVAAILALLYFRRRNAQSDGLPQGAGGYNGLGDGSWAQSQPVVHQVYELDRSGPHPEWMGNLKPCNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7L9</accession>
    <name>A0A370P7L9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_308048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7L9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="62904" checksum="529CB4708A329EFC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8M4</accession>
    <name>A0A370P8M4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_256744</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8M4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA19</accession>
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            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
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                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">ATCC 13157</strain>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK39009.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="702" mass="79265" checksum="CC03661B0886A106" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA49</accession>
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        <submittedName>
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    </protein>
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        <name evidence="11" type="ORF">M752DRAFT_256108</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="56549" checksum="40D9EE2B2D9C479D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA63</accession>
    <name>A0A370PA63_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_285872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976880" evidence="6">
        <location>
            <begin position="20"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="566" mass="62540" checksum="23E45A8478237BC7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAD0</accession>
    <name>A0A370PAD0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_256257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAD0"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023360199" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023360200" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="236"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="468" mass="49132" checksum="AEA05EACD12DDE05" modified="2018-11-07" version="1">MALPTHSAATTTMATFARMVKGQVRYYSAPLDMAIPASKQKYIPASGTYPKGFSVSGTHVGVKASNTRFPDLALISSETPCSAAAVFTTNKFQAAPVQASKNTLKATQGEGIRSVVINSGCANAVTGKGGLEDAVSMGAKVDECNGLAQPSTLVMSTGVIGQRLPISKILDKIPTAHSTLSSTHDSWLTTARAICTTDTFPKLLSQTFTLPSSPNRTYRLAGMTKGAGMIHPNMATLLGVLCTDAPIASSALQPLLKHAVSRSFNSISVDGDTSTNDTIAILANGAAGGAPITSTSSADYTAMQNVLTSFAQSLSQLVVRDGEGATKFVTVRVQNSPDYESARLIASTIARSPLVKTALYGKDANWGRILCAIGYTQGVAEGTVVPERTSVSFKPVDGSAELKLLVNGEPEQVDEDRAAVILQEEDLEIVVDLGGGEKGEKGLGGEEAIYWFCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAI4</accession>
    <name>A0A370PAI4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_239235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAI4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="58460" checksum="72D912891C8C9AC2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAK4</accession>
    <name>A0A370PAK4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_62250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF14">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="30752" checksum="6FC92CC6E5F19BCB" modified="2018-11-07" version="1">MSLNYKVFSSTRPGVNRSTPAGRDHLKWVPTTSTLIFGQRDAVLVDTQLTKAAAKDLVDWVVGTGKNLTTIYISHAHGDHFYGTGALLEKFPEAKVLATRETVSRMVEAINPEGMDGFWRKLFPGEIPEKLVMATPLEKDHIMLENERLEVVRLGHTDTDDTTALWVPTIGLVVAGDAVYNNTHPFLGESKSQEARSRWVAALDKILTLGPKIVVGGHSDPTKGYSPDAVQATKDYLDDFTRLDGQTSSPEELYSRILELHPTRLNVGSLWGGAMVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAT4</accession>
    <name>A0A370PAT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="34398" checksum="6A16AE00DC6E52B4" modified="2018-11-07" version="1">MATVKSTSSAPKGNAFVGTEGIYNLPHHQREIDRLQRQHNLILSSTGGLLLGMPLETNATLRILDAGAADGTWLRSLAEHYPNQKWSLHGIDIGSALFPPPSADGPIVDLQKHDIREPIPEHLHPPEIFDIIHQRYLVWGLRSAEWPQVLGNLRSVLKPGGWIQLVEAQWVDRDAPFDPVEFPNLAKMSEMQKWSTDAFGMNAYIAYELEELLRHSGFVNITKTSFAIGYGAVAREEQWKVTSAYLLVEGYRSLGHKMPPGGIPGVARTPAEFDAFLDDLRDEVLRHGYAPQLNIVIGQKPRNQLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB56</accession>
    <name>A0A370PB56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39189" checksum="CDBA2C34283C78C1" modified="2018-11-07" version="1">MVLLTSSTVSVIISTAVICTFTFLLFLSGYVLQQQSVRSIQHAIRPPPPPPAAVPVGAYQGAEQEFLSDRVADKQHKRDDEAGSTQATTGNFAYLQLLSTPDPSDICSAILFFKHLATNGTAVQDRLFMYPREWDLMPTKELTEPVATALSLLRTASLEYGIWLLPIDMTLATSEGYKPTDTKLLRLGQIQFMQYDSVLYVQTPGLLLDTAKLDAMLLSRPLPLRHDKNRPESFNNEAWLPMPLRAERDSALPPVYLITVNSVENGHIEARGHVPSTNVPGFSNLVTGPEGIMSPNEDGFNSDEQPGYVYFEQDDEGHVKWTHNPLFGSWRVGQNEVCEGLNLDDAVYDGYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB62</accession>
    <name>A0A370PB62_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_56708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB62"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="128"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="432" mass="48296" checksum="88E4793AD7022907" modified="2018-11-07" version="1">MPFWGTKSSQPASESDANSAHDAIEQKNDPVASASQAAGTAWLAGHLHHLTDDQEKKLEEFKKLCEERGYYKPGRDGEKASHDDATMLRFLRARKFDVDGAWGQFKDTEDWRRDNAIESLYENIDVESYDAARRMYPQWTGRRDRRGIPVYVFEIKHLNSKNMAAYNETMSSSTSTAETHQSSTVPQRLLRLFALYENLLNFVMPLCSKLPRPNPETPIVTSTNIVDVSGVGLKQFWNLKGHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPGTTSKIFILSAAEVKPTLTSFMDPSSIPKQYGGELEWQWGDMPYLDEEARKVVGVLESPPAEGETKPNFIKGPVLFKGDHVEILGKVNGESRKSNVPVGATPAQSNNNTSPVQVEKPTEQESSEGSENEKVPLQEPAPASETETQTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB90</accession>
    <name>A0A370PB90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="99913" checksum="9EC3917F72B785AE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS0</accession>
    <name>A0A370PBS0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_328823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="32186" checksum="092BF3CC02B4EAEA" modified="2018-11-07" version="1">MDMHDPKGIQGQGEIDMTALVPYFRLGLGLTRAQGEEAEKPWQIDQDLTDVQIPEHLETLLEDFSSGLGNGDCDERLIRPRLNATLMVLLAKIMKETRISRDDDESTCNSDLPSIDYSAPCWMADQKLIVSPVADFASHPVEITMHFILLYGRRPTLDTNLIVLRKQTILPDEGWGVLAAMSAIHRQRKEAGDNGDIYGIHTDTYTWNFFHLNNSGKYSTKLHLSWYLDQKEVIGRICQIIREARALSRKVGGRDSMLGIFESETEENSDDEMSDHSSLYQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC85</accession>
    <name>A0A370PC85_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_52936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="711" mass="77954" checksum="8013FC3DE39571C3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC90</accession>
    <name>A0A370PC90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_338111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39175" checksum="79680AF670E3C424" modified="2018-11-07" version="1">MPHKHKRREKDANTYNLPPNVIAKPLPVRDPSKSTKGKGGKGGKGKQQPPAKPTKQAIGERKAKSKSNSEWADDTPRAFRHLLQLQQKQQNGAQKKKRKHQDSDSSDSDEDVTPQTTNKNNKKRKAATTTTTSTTETSQAEGKAVKPQILPGEKLSDFAARVDREMPLSHMSRSAKPSATDVPKIRETRVTKHEKHLRRLQSQWRKEEAEILEKEAAEREEREEEMDEQLRLWKEWEVEGGKRKAKKKGLQQQQQAKVEADPWAKLKKERMNKQISPLDVVQAPPQLTKPREVFKVRGGAKVDVANVPAAGGATSLRRREELASERRNIVEEYRRLMAEKRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCE1</accession>
    <name>A0A370PCE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_238184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="144"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="655" mass="73780" checksum="D4D611961E2DCB0F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCR7</accession>
    <name>A0A370PCR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="7">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="7">EF-G2mt</shortName>
            <shortName evidence="7">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MEF2</name>
        <name evidence="10" type="ORF">M752DRAFT_277879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04092">
        <property type="entry name" value="mtEFG2_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001636">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
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    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="374"/>
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        <location>
            <begin position="132"/>
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        </location>
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        <location>
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            <end position="79"/>
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        <ligand>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK39983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="917" mass="99340" checksum="2D0A483EB1E0F931" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCX6</accession>
    <name>A0A370PCX6_ASPPH</name>
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        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_47258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000184">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1_DNA_bind"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="190"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="865" mass="96208" checksum="8C92F414BD62EBE0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD06</accession>
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        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_328689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017034469" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="158"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55014" checksum="6FAA649E3D595483" modified="2018-11-07" version="1">MAILSRLGPQGLLAVLLLASPTLAHGGHESVPEGAAISEDPIDTTLWIHMILMGFAFGVIFPLGMVLGIIRSRWHVPLQIVGTIIAVLAYFLGHAHKGRQFSKNVHASFANTLMLMMVVQIVLGVYLKLHLTKGIHGRIRRVIVIAHGVVGKAMPVASWVQMLFGGITAMGFCRDDHLGQCLAHFIMGSAFIAYGILLTILLLVGQYWLRRTGRSQEFFDSLIIAAWGCVNTFTEHRWGGPWVHNDLQHTTMGVVWWCAGLLGIWMSRKRNGRPKRNLIPAIVILLTGYAMSAHPQTLMISTMIHSIFGYTLMAAGFTRIIEISFVLRDKGSVSPDGSDPNSFQYLTPFLLYASGFLFMGATEEQMQLLNDAGITHVSYVLILYSIAFILFLFVNVLLHIYAVHAWPESAQAPSHSRSSSAADAGEGSSRYRPTANGRLMNGHARSPSEAQHLHDAEEFELQGLISDEEDDAKDTHAMGPRKTEDEESSPLVANGTAATTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDR9</accession>
    <name>A0A370PDR9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_41940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="465" mass="52639" checksum="76E3A7B89190F127" modified="2018-11-07" version="1">MGSLSPLLPASPRMLPHYFISVLYALFSSLLNLIPDHAKSHLFKSGRAHDFLPSTWKQVDYEIRNVLNPHGRYWWHTTGYVLNLLLQEAGYTDHAQRRILTFFGRSIAPHLGVANEPGAQRWPSFMTDNHNPIELSWDWHTGKKSPTVRFSIEPVGPNAGTQVDPDNQSADAHFREVLMQALPNTDREWFDHFDQALAPDLPPKGCMEGHPSKIFYAFDLSEEDITGKAYFFPGFKARTTKQTNLQVLAEAIRTAPHCSDNEKLGAFLMFEDFAQDPLTPPLEMDMLAIDLVRPADSRLKIYFRARETSFASVRQMMTMGNRITNPSLEAGLRNLRKLWDGVLAQTGVPDDTPLPAANHRTGGILYNMEFRPGSTAPNVKVYIPARHYAPSDWHVVTALNEYMYGINEKSELPMRTYTETLRKVFTHDALQQRGLHTYIACSVQSGGDLRVVSYMNAQSEKFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFA8</accession>
    <name>A0A370PFA8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_277526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="155" mass="16991" checksum="AD4C9F89378E8047" modified="2018-11-07" version="1">MSLASGVSITDECITAFNEFRMSGGSKGSKTKFIIFKIADNKKEVVIDEASQEEDYEVFREKLAAAKDAKGNPAPRYAVYDVEYDLGGGEGKRSKIIFISWVPSDTATLWSMIYASTRENLKNALNIHTSIHADDKSDIEWKTVLAEASGGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFI6</accession>
    <name>A0A370PFI6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="13605" checksum="2F28208FD2AA8F17" modified="2018-11-07" version="1" fragment="single">MCFYNQKRFKCGDWSWTSFAHRCNYEYRTGETCGMRLVNMTEFETTLCRLCEKIETKYRRRSAELERLNRWKREGSTLVASMDRSQKLVMELEKEIRQLQRERDDRRKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFU5</accession>
    <name>A0A370PFU5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="13250" checksum="F7DDE41D4B619DD3" modified="2018-11-07" version="1">MEAGSCHFEVSIEEMKQSVFGCAFLLYHGGFLEGLRVGGKRRVGMVDLCPIIFGNGTNDSATVPFRVLKDTVPGRLMLWQAENPYYEYTVRVYVKILLMLLAATAHGILKYVQRRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG74</accession>
    <name>A0A370PG74_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_302998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG74"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="61021" checksum="7831A41DADC1BC4B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGQ4</accession>
    <name>A0A370PGQ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_252726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGQ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="65"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="40213" checksum="5ECDA68465E91538" modified="2018-11-07" version="1">MTDPSVLVQSLTPSAIHEAYSLIQPYVHRTPLLTCQTLNTIASAPQSPEALSGTSSEGQTPANPKFRFFFKCENYQRIGAFKARGAFHALLRLIAERGQEDVQKRGVITHSSGNHAQALALAASTLGVPAYIIMPSISTLSKIAGTRSHGAEVIFSGSTSVAREAVVADVQAKTGAILIPPYDDFNIICGQGTTALELEEQYRELVAEKPNLSIRQGSTALDAVFTPIGGGGLNSGVATFFSDKTTKVFGAEPSFEGADDCRRGLDAGERVPAVSTLTIADGLRTPVGLLNWEVISNRNKVAGVYAVTEEQIKAAMRLVLERMKVVVEPSAVVGLAVCLYNEEFRRLVEKEAPEGWDVGIVFSGGNTTVEAIGKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGR2</accession>
    <name>A0A370PGR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_266918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="95"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="602"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="805" mass="85880" checksum="9A5043BEE986D69E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH35</accession>
    <name>A0A370PH35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_319686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017051148" description="Amine oxidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="48"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="61669" checksum="948B14769761A69E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHN1</accession>
    <name>A0A370PHN1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_302212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHN1"/>
    <dbReference type="SMR" id="A0A370PHN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044347">
        <property type="term" value="P:cell wall polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000260">
        <property type="entry name" value="Feruloyl esterase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016985287" description="feruloyl esterase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="85"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK41701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="281" mass="30525" checksum="B023B74F3CD3949C" modified="2018-11-07" version="1">MKQFSAKYALILSATAGQALAASTQGISEDLYNRLVEMATISQAAYADLCNIPSTIIKGEKIYNAQTDINGWILRDDTSKEIITVFRGTGSDTNLQLDTNYTLTPFETLPQCSDCEVHGGYYIGWISIQDQVESLVKQQASQYPDYALTVTGHSLGASMAALTAAQLSATYDNVRLYTFGEPRSGNQAFASYMNDAFQVSSPETTQYFRVTHSNDGIPNLPPAEQGYAHGGVEYWSVDPYSAQNTFVCTGDEVQCCEAQGGQGVNDAHTTYFGMTSGACTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI31</accession>
    <name>A0A370PI31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017076435" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="15028" checksum="970F38EE68C79C77" modified="2018-11-07" version="1">MQLLNYLPVALTTLGLTASASPLRRADSPALTWHVSNFTTGCSPAACTYTFNIYGVATANTPGFNATCTGNSNNTALTACGGNPQVQSRIQPATYPEWNIRVEHAWTLPGDMEFYAYGETNVTSPTPRFTIPVTEEYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIF6</accession>
    <name>A0A370PIF6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_302173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1547" mass="171091" checksum="31579732D66A002A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PII3</accession>
    <name>A0A370PII3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_336383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PII3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="29552" checksum="0C864169FBC54282" modified="2018-11-07" version="1">MATAENHDDLEFYPAYCFKASPTHFTWVKMAAVDVLRLKRRPEFPDPKIYFYKNHPIQYISLLGLITSRTEFPTVTILTLDDSSGVTLDVVVQKATPNSTPSSTLPTSFTPTQHISPTTSLPLDISPYAPGTFAHLKGTISTFRGVNQLQLERVFPVRDTNAEMRFLDQRSRFLVEVLDVPWRLGREEVERLRSELDMDEEEEEEEERVRRKRRRREERDRRRMGKMREREERVGVRRIIEGKRVEGVGSGGAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIJ1</accession>
    <name>A0A370PIJ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_293997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="92" mass="10898" checksum="DAE9A6D36F7DB00E" modified="2018-11-07" version="1">MGAIPEVDPDEPVETKPFKFVTGYDARFPQQNQTKHCWQNYVDYHKCVTAKGEDFRPCRQFYHAFRSLCPKAWTDRWDGQREAGNFPARLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJE6</accession>
    <name>A0A370PJE6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_15140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJE6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="25859" checksum="61270FCDD9C61ECE" modified="2018-11-07" version="1">MPEAPNNNPPSWPSRGPSFSTSIHPTVEAPPLTDYADLNTAHQGHAPTYPTVPTIFTGSTTWDNNHGDVHVHTDHISWPNDGQGMYLVPPMLATIPGSFQSTTDDHDITYIHQFSNGLIPQPYIESFENMSDAIVGMGPLNTRAGAGLGTGSMQEDIAEPRRIGQQCGWPGCKYTQPFRRQADLARHVQTIHERPQSFQCPECGQRFNRKDNMSDHHLRAHIRPQYSTTRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJF4</accession>
    <name>A0A370PJF4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_293431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="16576" checksum="B36102D11BB4AD56" modified="2018-11-07" version="1">MSTHPSKTYTSAPYHAGGVDDNNRLGGLYDSYTVSYAISQPENGLLNQAHFPVYHQTQADTHLGYHTLPRVSQPPRGQPPHDEIRYGFPTGSGNYGIATTVVQQAGVAPQDLYNQAGSIQGNGPASNPSILGTVTPMEYASPVRLDELHSKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJM8</accession>
    <name>A0A370PJM8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_326964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJM8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="77"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="641"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="104245" checksum="85FD8BAE5A7B0810" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJY2</accession>
    <name>A0A370PJY2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_251634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16334" checksum="B17EDF546A4A7689" modified="2018-11-07" version="1">MDPNTTAAAIDETPLSASPERRSSLEKHLQRRPDVQDLKDRHILLDTNVAPSLQATRQELARQRTTDALKKHLEHRPEREELVERNILPTTHAAPALQANARELEKHMLADHLDQKIQNRPNPEDLISQGILTEDEDPRFPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK21</accession>
    <name>A0A370PK21_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_215387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="44025" checksum="DF37D63809B8B5E2" modified="2018-11-07" version="1">MAPANREMGASTRALHVDDALNVVTDVAPPIHVATTFRYSDNPDDLVPWADRSGDQKNNTAHVYSRLTAPNYTRFEAILSSLLNGQAISYSSGLSALHAALVLLKPRRIAIGNGYHGCHGVISLFSRLTGLQKLDLDCPAEQLEAGDVIHLETPVNPEGTAFNIEAYAQKAHSRGAYLIVDGTFAPPFLQDPFEWGADLVMHSGSKYFGGHSDVLCGVLATQREDWAKQLLEDRVFLGSVMGNMESWLGVRSLRTLEVRVQRQSQNATSLVSWLNDALRAPSPAPGSDEAVVQRALEQVFHASLQKEDESWLLKQMPNGFGPVFSITMKTEDFARKLPSKLAFFQHATSLGGVETLIEWRTMSDATVDRRLLRISVGLENWEDLRQDLVNAFKELVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKC4</accession>
    <name>A0A370PKC4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_319357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="927" mass="102721" checksum="477208CD3C416CEB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKM5</accession>
    <name>A0A370PKM5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_292902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="74" mass="8140" checksum="B1F8547DCA1FEBEC" modified="2018-11-07" version="1">MRFRQWGCRRYSCFSSETIPLQTSTSYTMRAATLLLVALSAVALALPTTNNVERAAADANVRQMDELTVAAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKQ9</accession>
    <name>A0A370PKQ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_265666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="30445" checksum="F641798E1127DBDF" modified="2018-11-07" version="1">MEEARGSARVSTMENEPSQQLGYPKAISYIFMAPGLEDLNFVPNFGEIAYHAKGTFLSMGGTAMLERLPSGNVAKTPLSNPYSASLNERHRQSMRVEAHVYECLNGHPRIPKLIDWDPVACCLTLEYFENREPWRFRKKKSPINRRLHEEQMGKTSGRSDISPNNFLLDSNLDLKISDFAGSSVCGSPGSALPGISYRDPSIEFYVLRCSDDIFSLGSVIYFTMTGKHPYQDLPIAAVKDLFRRFQFPECWLLEVDAINVYEYFRRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLJ0</accession>
    <name>A0A370PLJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_265927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="312"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="504"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="766"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="855"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="902" mass="99353" checksum="290E6A87E02B7AA1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLS2</accession>
    <name>A0A370PLS2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016828263" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21301" checksum="102970400A3C00E0" modified="2018-11-07" version="1">MRYLSLISALAATALAQTPPGSYPSTNKNFGVAFPNATVTPGTWVSPDDVTSQPAVYVTDKLNKDATYMIFMLDLNIPDSDVTTAAYYNTLVPGLAVNTTTRLHWWGGNYTIQNGRFVNASDALAEYTAPRPRDSTNHTYTLYLFDQPEGYVPPEKALDGTYYSQTTSARFNFTLEPIVKAVGGPIAANYFLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM23</accession>
    <name>A0A370PM23_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_249898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="626" mass="69614" checksum="C6D08B98736B8E74" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMJ0</accession>
    <name>A0A370PMJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_326241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="326" mass="36247" checksum="ED9059FA1992B014" modified="2018-11-07" version="1">MADGGGWSTIESDEGVFTSLIENLGVKDVQFEELISLDADTIRSLSPVYGVIFLFKWIRETQQPTSTSSTTSPPSGTYDTDPSPNLFFANQTIQNACGTQAILSVILNNDSSSSSTNPFPINIGPELHSFKDFTAGFPPDLRGEALSNSELIRSAHNAFARASPFVDETVRNNQDEEGDVYHFIAYTPVDGKLYELDGLQPHPISHGGCTAEEFPEKVIEVLRQRIARYPEGETRFNLMAVVRDLRVTAKEIGDVEALEREERKRRAWAWENTLRRSNFVGFIGEVLKGVVGMKDAQGEGKYEEWVEKAKGETQRKLMRSGKADVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN23</accession>
    <name>A0A370PN23_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_335362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="31169" checksum="8A2D02C4D2781700" modified="2018-11-07" version="1">MSAKKHHPASRDPILDAINIRTVLTLLGTLLTIKLLNLLARLTGVRRTSPRYPYSYVGQAISRKEQHIIQILLEIIPESTSVNTSLPSNTGFSSADDRPTTADSVPSSSLVIPLMPVPSRVVQLSHSAPTRSLELAIADRDRGLDDHTSTRASVHFLGHQPLASDSVYSSIVRRSLSLSDPNSNCSSPHQSMLPGVRFSGFMSDRLRFSILSRPWSMDSVLADESQPEQVTLDMAQLQQTRTADSYPGPFPISDGLEPSSLATAQCANNGASEPTAVRTSVRPFTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN41</accession>
    <name>A0A370PN41_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_233305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN41"/>
    <dbReference type="SMR" id="A0A370PN41"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="60307" checksum="5483370E8C11C3C1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNC4</accession>
    <name>A0A370PNC4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_334577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="242" mass="26518" checksum="FC8F80E2228F7974" modified="2018-11-07" version="1">MICQRCRTGILSRLQQPQTVTLSIPSRARQFPIQRSQFRNYSDGKPSVSATPPPPAPRQPAGADITIPSAVSSATPGVSQPLSTPEGVHVDVNPEKPKKAAVERPPSSCAAGQKMNGLNYFKNKPDVVALEDSEYPEWLWSLLDDSKKNKTATGGVDPSTLNKKQRKRYEKKMAARAATLPPQIPIHHHATDITPAAYNAEAVPADLLEAAAESLDKRTEIRRSAREARRKGIREDNFLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE1</accession>
    <name>A0A370PNE1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="76"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="433" mass="48932" checksum="88C9F561012FC1F2" modified="2018-11-07" version="1">METSALSQRARTVVSSRNNLMWDILKNPWCPTTKPDGYVNVGVAENALMHDYLLEYINTKLTLPAKYLTYNDGAIGAERLRRAMASFLNKHLQPFKPLTINDLLVTNGVSSAIEHISWAFTDPGEGILLGRPYYGTFIPDMSLRPGATVVPVEFNDSDPFSLEAVDCYERALLTFQQDTGRKVRALMLCHPHNPLGRCYPRETIIRLMQLCQKYQIHLISDEIYALSVWENTVDEHTPVPFESALSIDTTGIIDPSLLHALWGMSKDFGANGIRLGVIISQNNPTLHKALQGVSLYSYSSSVSEHVAATVLEDTDFTTRYIQLNRQKMSESYAFAVQRLRENGIEYAPGVNSAFFLWVNLGKRYRELHPEQTADLGDEISDKVMQLLLQRKVFLASGVLFGSEHSGWFRIVFTHPREYLEEALRRIVVALNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE3</accession>
    <name>A0A370PNE3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">squalene synthase</fullName>
            <ecNumber evidence="3">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_313560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="45644" checksum="C3707D0552CB0B3A" modified="2018-11-07" version="1">MEYISSALYYVFHPYQLRDILKWWKIQHNQIYRLNLGNESESRKVCFKFLDQTGRSFSAVIKELHPELLVPICIFYLVLRGLDTIEDDPSISVKAKAALLRGFEDVLVKDGWTYDGNRPEEKDRELLVHFHHVINEYKALKPACRLIIKDITRVMGNGMADFCHKVTLNNPDKAGVMTIVEYDLYCYYVAGCVGEGLTRSFIEAQLCNSSLLDYPKLSRSMGAFLQKTNIIRDVSEDHGDHRCFWPKQIWSKYVSDFADLFKPENCEAALDCSSEMVLNALEHAKDCLVYLAGLNEQSIFNFCAVPQSMAIATLELCFRNPALFERDVNIKISRGDACQLMFECTQGLPGLCRIVSRYARRIKTKNSLSATNLSEINTVCDTIEKAVEELFHPEEGQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNK2</accession>
    <name>A0A370PNK2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_291944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="38897" checksum="D1BE8C0C248347A2" modified="2018-11-07" version="1">MPTALVTGGTGFIALHVIKLLLEQGHKVHTTVRSLRNPTKCKPILDLQFRYPGQISLFEADLTKDGSFLQAMEGCDFVYHIASPFLVPSQIKDGLRDCVKPALRGTRNVLESVNQCQAVQRVILTSSVAAMYGDCIEIHSVNKGTLMESLWNETSSVTNNPYHYSKVIAEREAWKIHAAQDRWDLVVLNPGLVLGPSMTPESVSGSLFMIENMFRGNNRMGVPELYYPVVDVRDVAEAHVRAGNMPNSNGRYIIAGSGETFSLLELANMARSVHRDMRVLPNRNLPRVIVYLAGPFVGVSRGWISRNLGVRFSVDNGRSVRELGMEYRPVEGAIKDHYETWVERERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNU6</accession>
    <name>A0A370PNU6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_318415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNU6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="686" mass="75444" checksum="90A90BCABDD6958C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV5</accession>
    <name>A0A370PNV5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_146331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="329" mass="38941" checksum="9BF3BC6156F30D8D" modified="2018-11-07" version="1">MDSASETTEDIVTANGERIVEKIHGSKRGQPKDRRPVHDGRQNPAAGANPSFPPYEPSKPRVAQRRRSYTRLRPEVRMISDTESDLELPYRHQRPRATSIIHHDTSFPRRYPDNMHSPLTKLDLEILLQQKQIDRLEEDLHRFRLSREEKNRHLAEDGREFEDEISERLRRLNEWERKEARTTRAERRTEEQAKIRRLEKAELQAKRKGEIKAALREKEWKEMKKKFRRKSEERERLIQENRIRRAAVEDYKLAEEQRLLEEERQKRQLRKEYRAAIEAELGYSLEQVKDILAKAGGKKGQTQRRGRNKQISAAVHDAPSGDEADEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP79</accession>
    <name>A0A370PP79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_148561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="130" mass="14387" checksum="57493BD89225B90C" modified="2018-11-07" version="1">MHQISHQRQEIWYVPSPGGFTINIPYRYTSLASPIITTTPGINSHHEHHHQPPPEQPPSSSPLPAPSPPCHYHHLRHYLYSHSAPPIPEAGHPAAHSSSAPLAAASRELDPPRPVTRTSTCAPCTNIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP86</accession>
    <name>A0A370PP86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_334842</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP86"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="154"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK43999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="38930" checksum="E8D2D061EE155CFB" modified="2018-11-07" version="1">MSAPVFLGIIGVGGVGTAFLHQLARLPNAPKLILLARSTQTLLSPTPSYSPSIPAAEWKTASATPSLTKSGALSAEEIANYLSSAPGRSILVDNTSDPALAASYPIFLRKGISIVTPNKKGFSSDLSLWKDIFASAAQGNALVYHESTVGAGLPVISTLRDLVATGDEVTRIEGVFSGTLSFLFNTFAPVGGAGAGRKWSEVVAEAKELGYTEPDPRDDLNGMDVARKLTILARIAGLEVQAPDAFPVESLIPEELRGLDGSAEGVKTFMERLAEFDGQMTEIKESAEKEGKVVRYVGSVDVGKKEVRVGLQRFDKDSAIAGLKGSDNIISFYTKRYGSNPLIVQGAGAGGDVTAMGVSADLVKVVQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ73</accession>
    <name>A0A370PQ73_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_334286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="512" mass="55660" checksum="0D8E8D6173D4E0CE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ79</accession>
    <name>A0A370PQ79_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="323" mass="35256" checksum="6B4D4F7701BF7D89" modified="2018-11-07" version="1">MFGIIADLLSSIITILLPIFASYKALRTGDPSQLAPWLMYWVVLSAVLMAESWTIFILGWFPFYSWIRLFFFSYLVLPQTQGARSLYQEYVDPFLEHHEREIEEFIGRSHERAKALGLQYFYQALDYVRENILGLPAQRPASPPPPTGPAAYAQSLLSRFNIPTAAGGTAPAASNDWLSAIGSAVASVASGKSAEARGEELSASGTLLPREVASMSRADKAKFISNQRDMLEVLRSALAKEERDLHSAGAEGDDLAYGGAPLRKNRSENSFTHVEHEDTQERSSDAHGRTSSGNWASGWFGGGEQAGSSGVDHGSEGARSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQL3</accession>
    <name>A0A370PQL3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">M752DRAFT_291632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQL3"/>
    <dbReference type="SMR" id="A0A370PQL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="208"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="288" mass="31721" checksum="4866C35FF0F8548C" modified="2018-11-07" version="1">MSKLGNRADWADDEEFDDPSALPPQQITTNKDGTKTIVSYRFNDEGKKVKVTRRIKTTVVREHVNPQVAERRSWAKFGLEKGNAPGPSFDTTSVGENIVFRPSVNWKLQAAEAEKNGGEKGSVKDQLKDKKVKCRICSGEHFTARCPFKDTMAPVDEPTAGGEAGDEDSPAAGALGAGTSSYVPPHLRKGAAGGGERMAGKYEKDDLATLRVTNVSELAEEGELRDLFERFGRVTRVFLARDRETQRAKGFAFISFADRSDAARACEKMDGFGYRHLILRVEFAKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQU6</accession>
    <name>A0A370PQU6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_264464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQU6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="143" mass="15928" checksum="FCD94E31DF606A38" modified="2018-11-07" version="1">MYHISPYQRTLNIIQIMTGYAKKRPVTKSDLKLAGRSEVNHQEVLSLNCAFGERWWYRSNYMGALLFSSATFILPAIYGTLVKIWIANIDASLVVTIDVYTHIGTVTEVINKGLPRAVWSTIADKGARSLGARLGLAHSLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRZ9</accession>
    <name>A0A370PRZ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_210956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRZ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="649" mass="71401" checksum="67A705BA99CD41C8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS74</accession>
    <name>A0A370PS74_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_131752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS74"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="11952" checksum="07F9707F5818F1D7" modified="2018-11-07" version="1">MFHHPCRSGSKPSRALSDHSVKQVLACTIMFHPPPSCRSRPPDSLLHIHILRVALVPASLACFSFSPLSALIVSLCDTTFIPFVLHSHLRQALDGPSKALCTLITAGTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSS0</accession>
    <name>A0A370PSS0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="38719" checksum="C33BD4B993AEB5F6" modified="2018-11-07" version="1">MSADNTMRAVVFRGPYKVAVEERPVPRIQDAGDIVVKVTYTALCGSDLHVYRGIEPSGTGYVMGHEVTGVVVETGDAVQSVQKGDKVVSAFTTSCGKCYYCKQGYSSRCEQNMLLGCDHLDGAQAEYIRIPNADGSVVKAPEGVDEKYLVLMADIFPTGYFAARNAFKNSTKEQIAEQTVVLIGCGPVGLCALINALEYKPKHLLAVDSVPARLELARSLGAEPWNFQTDREGLDKRVLELTEGRGADAVIEVVGLSPALKTGYDLLRPFGTISSVGVHNGEIPWNGCEAYGKNLTVQMGRCPVRSVSEEALEVLKKNQHRLGFMADKIMPLSQAVEAYEIFNAMKVQKVIFEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSZ8</accession>
    <name>A0A370PSZ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_117396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="529" mass="60183" checksum="25B19F3E4AE36665" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT70</accession>
    <name>A0A370PT70_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_263026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT70"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="167"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="46690" checksum="A6FF0FAB5856CF5C" modified="2018-11-07" version="1">MADPTDLNLDAPSDLQDIPDMSMQLLPPPEGTYPDKATLLAAVQAHGKAHGYNVVVKSSSTPTEKKPGRTAKVWLRCDRGGHYRPRNGLTEETRKRRRTSRLMDCPFMLVAAGTPGIWTLTVLNATHNHGPIVEKPRQVPHHKVRKGQIAAVPYDWPHDATLTPYTTALVIIDMQKDFCLPGGYMSLQGYDISANQALIPKLQHLLNAFRSSGFPIYHTREGHRPDLSTLSSREAYRSQNNASGMGIGSPGPLGRLLIRGEVGHDTVDELYPVHGEPVIDKPGRSAFAHTDFELILRNRGIKNLVLVGVTTDVCVATTMREANDRGFDCVVLEDGTAASEPSLHMSAIESVKMEGGIFGAVAKLEDVMHAVENFKAVTVKKLAPQMTWPSDFIGIKSGIPFSAINIGGMSCHWVRGAIIRTDKDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT81</accession>
    <name>A0A370PT81_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_311469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="392" mass="42973" checksum="150E82124485FA01" modified="2018-11-07" version="1">MLVFLETLQVSEGEGHQLICAVLEFILEPPVVGLSDPPPMFEAAADSETGEFAGHTAGDREAGMTGDGEATDDSTEYAVRPEVSDDGTNSWETVDYSDSPVRDSESWIETVERDDEYGVDEYGDYCEGKSEKLFSNDPGTQVDTDDRGIFLPESMFDYPEEEVHFSDHGYAEKQQEDNEETDELDMMTTQYGQMGANSFAIRDNTPIQATKENKEGPSGSETCSECDQLVRENASTSKMLNAETTSSQLPAALVAGPDAEQTGAAEPAGIVEIVKSLTLEDMAGSWWDEVLEAMEAGFEEAEAVFRKVASAGFTDIEVNPSLAKAKTAPRKRRPPKPEKPRKGPASRNPDCTDPEKDFYDVCWSILNETGLVGEYMRDRMLVSVSTPNRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTI1</accession>
    <name>A0A370PTI1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370PTI1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="144" mass="15969" checksum="8BC484CA66A90A30" modified="2018-11-07" version="1">MSHKARDFMELKSTPLVLPRGAWCMFNFVEGDVPLPTSRPRNPLALKLSSGSPKDTGNGTPGTVVERSGVIPFEDGDVPCTVRLPEDAQIGEVLRYRFEGCKLTWWDWGVKEDHINTNVDPPDSNGRPEVLIPTSNILQLTVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTZ3</accession>
    <name>A0A370PTZ3_ASPPH</name>
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        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="204" mass="23780" checksum="BCD21DE22C7ACD9D" modified="2018-11-07" version="1">MPDSPPRRRRSRSRSPRRQPPKGPGGFRWKEKRAPRDDNPNPDTDRALDRGYRARSPPRRDTHRDRDYDRGDRYRRDYSPDRARDRDRDRDRDRDRDRDSTKPKKTDSEKKEKKEKKKKLKPASTEEMILVTVNDRLGSKATVPCLPSDTVGDLKVLVAAQIGRAPREIMLKRQGERPFKDFITLGDYSITNGVQLDLEIGTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV52</accession>
    <name>A0A370PV52_ASPPH</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_209357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="779" mass="85031" checksum="BD363729903E3E53" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV79</accession>
    <name>A0A370PV79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="310" mass="33880" checksum="2A3FCA12B6A3E74E" modified="2018-11-07" version="1">MSISLPPSYESHPTSHIKLSHHPPNTPSPTPVIIITLNRPEKRNAFTSTMAQELEWAFTTLDRDPRVKVIVLTGSGDTFCAGADLEIGFSVGEKGKKLNLGDYRDSGGRVALSIHRCRKPTIAAMQGSAVGVGMTMTLPAAIRIAHTPSKYGFVFARRGITMESCSSYLLPRLIGYSRAMYLVSTGAVHPPTSPHFGGLFAETFPTKEGVVKRAVELASEMAQLVSPMAGALNRALMWRAPGSVEEAHLLESRVLGHMFASQDQKEGVGAFFEKRKPEFKCDLDVDGPGNYPWWGEVDIDPRKEVEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV97</accession>
    <name>A0A370PV97_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_246986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016613313" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38465" checksum="96FDDD8858D47DB8" modified="2018-11-07" version="1">MSAALFLGLLGLTAPLAAATASTPGLELAYSLERATQGISISSDGRKFLSQRYSTTLPPQIVELLDDNSTVLYPNAAWNSYNSSDPTSDPRKTFVSIDGARMGPDGRYWIVDGGSTGVNGSTKLVGVNLTTDAVDKLYYLDAMKASDSGIDDVRFNAAGDVAYMSDTAGALLVMNMTTGTGVRVLSTDSSAQPWFPMMYNGTLVPGHGAAGSTLSVGLDQIEVSPDGVYLYYQPCNGGLYRIKTAYVDASLKNATLASTLGDYAEPFALTPSTGGSTIDGDGNIYVSDTNLLAIWKVTPEGRATILIQDEKLLWTDLMWVTADKKLWLPASQMRPGGDGLMADGPNYIFTYPIDAGPSPIDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVF1</accession>
    <name>A0A370PVF1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_317273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVF1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="3"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="473" mass="51495" checksum="18731926CE34F11D" modified="2018-11-07" version="1">MIVSFYGTQSRKFYRMDTGIIGPVTVMDSFVSRFGSQSSTIHGLIVSSILIPAAFSSFFAGYLADKMGRPKSISIGALIFAIGAALEAAAVHIGMFVVGRCIEGIGEGLYLGTLVVYICEISPPRVRGALTTGPQLLITLGLTIGFFTCYGTSRMKSSFSWRTPFIILACLAATFSMASLLWLTPSPRWLTLHGRRSEATAVWDYLDVSQAEREKIEIEQTQSVNTEAVASASSDIHAPSVYQRQDRSMKHKFFDLFSKDVRTRTAPAVFLMGMQQLSGIDGVLYYAPLLFEQAGLASSDASFFASGVSAIVIFAVTIPALIWADRWGRRHSTIYGGIGLAVTMFLIGGRWVVIVCIYIFAVIYSLSWAVGIKIYAAEIQPQRTRASATSLAHGSNWTANFLVALTTPILLSKSSSFGAYFLFGGCTLITACICALFMPETKGRSLDEIEEAFKSKSLSRTLLKALRPITRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVN2</accession>
    <name>A0A370PVN2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">M752DRAFT_246101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000005">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="339"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119860" checksum="EA4CBBE36307DB60" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK9</accession>
    <name>A0A370PWK9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_104084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="375" mass="42279" checksum="0B377E35151DE790" modified="2018-11-07" version="1">MPSRRSHTKSHHGCAQCKHRRIKCDEFRPICGSCHKKHIRCSFEGQITPQISHHSFAASGTRVDLIPRNDGFQLPLLDLDLLNHWHVATVRTLVHDKSTEKVLREFVPQEALSHPFLMHSLLALSALHLSHHGPVERRHKYTEAAMTHNNISLSLCKPLLNNVTSGNCHALFAFSCFVVMFSFAAHGPKADPGALRLSAVLEVFMLIRGVASIVGQARPWIEAGGMRDLLKLGEQPREESKTTRARELYTRISDIYDNLRRPSRPDCYDSESLVIEESVQKFLDLLQQAISVANPVPSIMMRWPAVVSVKYLDLLQANHPKALVVLAHYGVALELMAENWWLDGWGAFLVNIALHRSGPDYGPELVWARKAITRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWR9</accession>
    <name>A0A370PWR9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_310138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794073" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60813" checksum="A5AF8D46743D0D23" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWX3</accession>
    <name>A0A370PWX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_244669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="371" mass="40843" checksum="5C42177933D97420" modified="2018-11-07" version="1">MATHPAITVPALKGPLTIEHVPTLKAEHHDVQVRVEWAPTSHLDVYQVDAGVMVQFPQILGDSAAGTVVAVGPDVKRLRVGDRVFGMFFHNKTQKGQQVYVTAPETLLGKVPQNIPLSAASTIPTNFCTAFFPLFEKLKVELPWPRPENFTPSDKDLPILIWGAASSVGQYAVQILKYWGYSNVIATASPKHHEMVKAYGAAHVFDYRDPDVTASILNLLKSQGHQQSIRVFDCINSKSGSLIPISKIATQPGSAVAAVLPIVISRPSEKDGLQLSFDVSTEAPWASGVETHPIVVYDYEKNDFLRDHLQTEILPTLVAQGAIKPNKQRIVEGETLLDRASKALDILRSGTVSGERLVWQVWTEEEFPEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX11</accession>
    <name>A0A370PX11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Inositol oxygenase</fullName>
            <ecNumber evidence="4 13">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_261698</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12 13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX11"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="35885" checksum="EDADCC05C7BBE84A" modified="2018-11-07" version="1">MPSVEISLAPTNIEATSDMIDAVNVLRAKNTDPATSKNLYDDSEFDKAKDKTTFRQFNDACDRVKNFYAQQHTLQTVAYNLKARHNFHNKTRAHMTVWEAIEKLNTFIDECDPDTQESQMTHLLQSAEAIRQEGKPRWMQLVGLIHDLGKLLFFFGAQGQWDVVGDTFPVGCAFDDRIIFGTESFKNNEDIKNPIYNTKFGIYSPGCGLENVMLCWGHDEYLYHIVKDQSTIPDEGLAMIRYHSFYPWHRENAYHELMNEHDKKMLAAVRAFNPYDLYSKSDSVPDPVKLKPYYLELIDEYFPNKVLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX56</accession>
    <name>A0A370PX56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_272573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="341" mass="37014" checksum="D090919F3F8C05A2" modified="2018-11-07" version="1">MQSGISVSDELHEAFRNFVSDESIFCLPVTIKSESLSPLSPVPFASPNAFYPSLSQLSSVLEPKTPLYLLIRRPEGGSSSLVALTYIPSNAGVRAKTLFAATRATLARELGTEKFASTIFATDEDEVIGEEAWKERDAEKKGTAGGFRREDLMGEKERELEAVRRAEEEARSGTPSRDIGIGGTFNRANPFGGASVKMNVDDEVKQALEGLQQGGLVQLAIDVPTEAIKVAAAESGVDANSVQSHIPSSSPRYTLYHYPDSDVVIFIYTCPSGSSIKERMLYASSRMYAITMAGDQGLKISKKIEASSPDEITGERLHEEVHPPQDNGPSRGFARPRRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX86</accession>
    <name>A0A370PX86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_272592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="39710" checksum="A83E25CABB00EE07" modified="2018-11-07" version="1">MTTRKRNDFLGIAESDDESANDRGYDSEAAEQEKSKGRAVKRRRMQPVPQPQSTNDLHGLNDDSEEDESDNGVGLGDSEDERVVMKGRSKSKSKKQAGSDDEDDEEEENDYNNDEDHYLDATTEVEAKKSTSKKPLDKAKKAPKKNKTGVIYFSSLPPYLKPFALKNLLETRSFGPITRVFLSPEVRPASAPRRRSNKRKTYSDGWVEFASKKTAKICAETLNATIIGGKKGGWYHDDVWNMKYLKGFRWADLMEQVQRERSEREARKRVEDSRARKEDKVFLEGYEKGKVIEGIQKKNEEKGKKKKDSAKEVRMVFKQNEVKLGRDKSAEDPGRLGDDTKRVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXP6</accession>
    <name>A0A370PXP6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RDK46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07876">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="11636" checksum="AB6BCA31E9F99CD6" modified="2018-11-07" version="1">MAPIERITLFKIPNDADRDRVLEQYKVLAKTAVKDGKPYILSSAAGASIPDERNQGWNLSVKTTFASLEDMVYYDEQCEAHKALKAVVGPVRTDKLTTFFESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY27</accession>
    <name>A0A370PY27_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_289193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY27"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="29707" checksum="4D49B43B33F12849" modified="2018-11-07" version="1">MAAGIGFSTEPMPNMTPDYEVRLLLNPAKVLSSEHELTDDVRSALNLAPTAIKLNVQFLDTCAKEIYTAGWSARIRKADNEDDLELTYKKRYAVTDGGIDSALTAAKNDGFNAGDTKYKAQIEWGYERQILSISRKKTVADGKMDLPGTSDSREMLIDEAPDKFKNWRPNKWGTSVLAMSRIYGPVFVRRFVGTWGTMPLYVEIWPLINSERTGIEYIVEASFKTENIMTASDERSNLITDLQSKGWLLPKESLKTQLIMERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY56</accession>
    <name>A0A370PY56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_272875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY56"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="776" mass="88590" checksum="13D0BC7B17A565F9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYF6</accession>
    <name>A0A370PYF6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_306593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="60826" checksum="AEECB567864D8C6F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYF9</accession>
    <name>A0A370PYF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SART-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="672" mass="76273" checksum="73B5E1A2B74C56E4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYL3</accession>
    <name>A0A370PYL3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_228373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYL3"/>
    <dbReference type="SMR" id="A0A370PYL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="706" mass="79368" checksum="80EDD8649B60B574" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ27</accession>
    <name>A0A370PZ27_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_322521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ27"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57017" checksum="B600DFF5D2A8654E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ35</accession>
    <name>A0A370PZ35_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_322533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="33114" checksum="B66311D1C0B74C46" modified="2018-11-07" version="1">MEHPPPSHYDELSPPSSVAGQIWDMALTDPDYASHILDSHDTATPASARLTRLAHLASHFNPTSKSDSMTLHHCLETLESLLDPRPALTQELARCRPMSHSRQSNSIASISSTDSQDLGDSVASLEERSHPPLKDILSEVTALKVEFDRRRKESSEIYDLLTRERETLARRIGELDDEIHELNTDILEDSAEREAIQGTIRGLESWVDEWHKQRLLIAAKKQSAAPRRNGQRRWTKCKVEDVEGDGEALFEGITAWMRGWKDVEEVFRIREQNRTFRREERQKTRAKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ41</accession>
    <name>A0A370PZ41_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_331311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ41"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="54845" checksum="D4C74284DC1C4309" modified="2018-11-07" version="1">MAFIFYQRLPAVTVTGILSRQTRPAFVKPAFTSRRAFSITPTHTMLSTELTEAEVSALRANKERLAKDLHHSCQWGYGIRWGDGHTDTGMQRLALSQEDKQVRDWFIETTKALKCEVTVDEMGNIFAVRPGRRTDLPPTFIGSHLDTQPTGGRYDGILGVLSGIEALKVIDEMGLETEGGIGVVNWTNEEGARFPISMVSSGVWAECISLERAHSLKEVPTVASLPTASSAPESMKSALEKINYLGSVPCSYKQTPMAAHFELHIEQGPHLISAGQHVGVVTAVQAYRWFRLTIFGRDTHTGTTAFEHRADALYAFARMMVRAREVASSHGCLASVGIVEAKPGSVNTVPGTVSFTLDIRGPESELVQVVEDQLRKEFDSIAAEEGKGIGKPCRVEWTLDFDSPAVKFHPDCIECVQQSAEAVVSDVNAAEPKSLMRTIMSGAGHDSVFTSKRVPTSMIFVPCKDGLSHHPEEFCSADDCATGASVILQAVIRYDRKRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD6</accession>
    <name>A0A370PZD6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017059689" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8362" checksum="FABB45A785089F87" modified="2018-11-07" version="1">MNFTHILAVLATIGLASAAPANSDPSQCTTAQANSCCTSLTNGILNVNVLPALCVPLVGNCNNQAACCETNGIGLLNCLTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZP5</accession>
    <name>A0A370PZP5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="691" mass="77274" checksum="21B78CAE2711AF3D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Q7</accession>
    <name>A0A370Q0Q7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hybrid NRPS/PKS enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_331751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="7"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="943"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2364"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3511"/>
            <end position="3590"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2459"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2476"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK48029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3941" mass="428980" checksum="1A004D273EAB22AC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0U0</accession>
    <name>A0A370Q0U0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_261365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016876931" evidence="2">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="189" mass="18523" checksum="B6D37888B43075AC" modified="2018-11-07" version="1">MRSSILLVAFSALAAAQSSVAVPQGQPSAAVTSSPVIPTQGSLPAGASSVLIGSSGVPSSFAKSASASASTSTKTSTKTSSSDSSTSTSDSSSKSGSSSSSSTSSGAGVPLATAGPVGLSVVAGAALAAFLDFWNAETAPFISNPTTCIDNKSCATLKGTILNVIPKPTVIEASKRPRFHIHSLVTSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1A4</accession>
    <name>A0A370Q1A4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_227288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1A4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="218" mass="23727" checksum="90D5217FBD508772" modified="2018-11-07" version="1">MTQPNPYVLAADNPGAVLTLLQSNPSIASNQDEHGYSLLHAAASYGHIDLLRALVKDYNVDANLLDEDGETCLFVTESLDIAKCLVEELGVDYNKRNDEGLAAYETIESDGSFPQIAAYLRQVAGVPEPAADSADDALNPAPPLPPNIQMNLGTVSEQEASAGMDEVDPEFKRRIDELAAREDFHSEATQNQLRQLVMDAISGSGINTQERDVRRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1F9</accession>
    <name>A0A370Q1F9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_272459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1F9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="207" mass="23468" checksum="491CC73B8DDA237C" modified="2018-11-07" version="1">MGNTNSTHKISAQDRAILDLKNQRDKLHQYQKRITVLTDRETEIAKQCLARDDRKRALLALRRKKYQESLLDKTDKQLEQLEQLTGQIEFALVQKDVLFGLQQGTKVLQTINKEMGGLEGVEKLMGETEEARAYQEEISEMLAGRLSTQDEDEVEEELEALQRDTQGPVVLPNAPSSTLPEHVGGVKEDEHAVEEEAYVEERTAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1H2</accession>
    <name>A0A370Q1H2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1H2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="415" mass="45530" checksum="76A9F80C792EC4BC" modified="2018-11-07" version="1">MMHQQFSLECSQPHPVYSNNAAMSDAATGVARGKRHAACDECRSRKLKCSGEATGCTRCIKQSLTCHYSLQKQMGRPPKKRMREDEDPSPPFGLPGNEPWTSESDFASLGPSTIESTETAPSDYSGQINFFTDANSNIDAGQFLLNKPIDAAPTTVSPWPDFSNVSSSAANLYTLPPDLSLLQQSSAASSPNSEESDRQCPCLSCLYLCLSHLSSLAPFPLSHHNLCSLYIASRTARAVIRCQICPLRFTTGMQNVTFTGTLLTVIADTWLRISKVNAVDFGRQSAPPAYAAAIDASPNPAKGWEDWLRQTVRYRVIGGPCDPAGMPPGADDGPSLLSLIEEMEERQRRWHRSHPLPVEERHLPIPKTDGSKEEESCHERDALCMRIIQSARNVIPKFGFQPSDYPDDAVAKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1I8</accession>
    <name>A0A370Q1I8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CHY and RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_288770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1I8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="480"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4H4</accession>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4H4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="9566" checksum="856AA0AC48EA84AC" modified="2018-11-07" version="1">MYMYISNVVFLVLYSLSLFRPSSFCQMYIRQRMNHVSCRELVVRLSLSFFLLSFFFFFFFVFSPLISHIYLREEHPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5C3</accession>
    <name>A0A370P5C3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_330621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5C3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016664009" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="102" mass="11063" checksum="BA5DA8CBBE008610" modified="2018-11-07" version="1">MKLFSTITASALALAISVQANDCTSGLSYCAGVLDDVDATRYNAEMWKQINAKYGKDWNYYIYSPGDFVWHCGAGGAITMGTRCGWGCVNEGAGNSDHCRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5F6</accession>
    <name>A0A370P5F6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_105208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5F6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794061" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="19784" checksum="A531E16EC94ADF51" modified="2018-11-07" version="1">MRFAITAASLSLVSSALAITITQPTSGTEWDFSTPKTIKFTSDANDPSVISIILRTQDGSFQTKLADNVKTSTGEYTTQPNPSISNGSDYEIEIIDSSGELAVSPTFTVEKGASTDGTTSSSSASSTSTTSSSSSSSSSSTTTSSSSTSSETESTTVTSTTAVSSTSTSSSSPLSSSSGKMSFRHCGTATSLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5H1</accession>
    <name>A0A370P5H1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_106791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5H1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="141"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="60318" checksum="7D11BA4CBF5371C0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5N0</accession>
    <name>A0A370P5N0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">M752DRAFT_279903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5N0"/>
    <dbReference type="SMR" id="A0A370P5N0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="160" mass="17793" checksum="E1BDEC77EF0CDDE4" modified="2018-11-07" version="1">MSLATLDTAQHPSLPSASETLFKAKAAKKLSFEQIAQHIGRNEVATAAIFYGQAKASPEDIEKLSGLLTIPYDALEERLSGFPDRGRSVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDADGNNWAVITLRGKWLPFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P628</accession>
    <name>A0A370P628_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZZ type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_279841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P628"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02341">
        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="444"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="815" mass="89794" checksum="8321D8F73D3B19F5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6K5</accession>
    <name>A0A370P6K5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_241378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6K5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK37505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="36875" checksum="7B43899E0527C22D" modified="2018-11-07" version="1">MSLGKKVTLNSGAQIPQLGFGTWQSAPGQVGDAVYEALKAGYRHLDLATIYQNQREVAEGIKRAYKDVPGLKREDIFITSKLWNSQHDPAVVEKALDECLAELELDYLDLYLVHWPVSFTTGSELFPLVKDSSVEGGDVVINDNISIVDTWKAMTQLPKSKARTVGVSNHMIPHLEAIINATGVVPAVNQIERHPVLQSNELIEYCQKKGIHVTAYSAFGNNGFGVPLLVTRPEVKEVAESASKRLGTTVTPAQVILAWSQVGGHSVIPKSVTPSRIQENFKEVELTPEEIAKVSELGKDRRRYNTPYVANTPRWDIDIFGEEEEKPAGHKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6L7</accession>
    <name>A0A370P6L7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6L7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="73361" checksum="CC6868A1AF4CDC3B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6R2</accession>
    <name>A0A370P6R2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_287002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6R2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000061">
        <property type="entry name" value="Aspergillus niger contig An11c0010, genomic contig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="24"/>
        </location>
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            <end position="541"/>
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        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="541" mass="59104" checksum="FD97639195432AC6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6R4</accession>
    <name>A0A370P6R4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_321729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RDK37546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6R4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="978" mass="104237" checksum="F78985F37E72D29E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6U3</accession>
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        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_287007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
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                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
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                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000168">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="RDK37580.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M7</accession>
    <name>A0A370P7M7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="176" mass="20294" checksum="B1199579EF3796F9" modified="2018-11-07" version="1">MAIYLSQPIIDEVVRFVEEDSRYEDSVKAMAAGILTYYFPIANGFLVVPEQNRGDQFPDFIIFRIQRRFPGDRSVVDHTVTEAKKSDDSIPASLEQLQNALEHSNTGFRRCWAILVHGATFYFYEYHESLPPNNRLLPWAPPGRPQGQNAFHARQNSVEIDWMLRHMAQNDTPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Z9</accession>
    <name>A0A370P7Z9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrogen assimilation transcription factor NirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_257110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Z9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="708" mass="79407" checksum="F44128DEF704735A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8A0</accession>
    <name>A0A370P8A0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_329767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8A0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="188" mass="21215" checksum="583C62C736858F22" modified="2018-11-07" version="1">MPAYHSIFLEDRDVPVIGNFPILPLRTRTRGPAYTLPPLPPTADTTDVPADSESYDCVDEILSLFRANVLFRNFEINGPADRMLIYGTLFISECLGKVKPGMAMREAEKALINVALDHFAIPGDVSFPLNQAFEAPRDRQDAETLRQYLSQVRQEIAVRLHARLYPGGEGPSKWWLSFAKRKFMGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8B9</accession>
    <name>A0A370P8B9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8B9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="34700" checksum="958F5E68D3DB42FC" modified="2018-11-07" version="1">MRFLRVSLNHICQGTRRLRTSSLLPQTRDSQQFFPNDVLDIPELDAHNIVSSKDTGHVRQVHHHLENRGALKVNLGFPDPNSDYLQQLVLSLHGQYGHGLPFSHSSSRGWFRDVRPQPETLEHRAISETMGHFPWHTDSCYETEPARFFALHVLQHDRLGGGTLSLLSIDLLLRSIPSSAKLALSEPEFRLAVPLEFSKGEQNAIIGNLLSMDGKYTRLRFREDIVTPLSARADAAFHELLHSLAQQKTTNAQHLRSEALPQGSIILLDNGRWLHSRNHVRDHKRHLRRVRWDARPFGKHVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8E8</accession>
    <name>A0A370P8E8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_240222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8E8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="277" mass="31329" checksum="C01E72F7D5C603DD" modified="2018-11-07" version="1">MSTTTATAIQSSRPPIIPKDFSAQQPKTIRLYPLSNYTFGTKETQPEEDPSVLARLKRLEEHYDLHGMRRTCEGVLVCHEHNHPHVLMLQIANAFFKLPGDYLHFEDDEVEGFKKRLNERLAPVGSQFSGEGVNEDWEIGDTLAQWWRPNFETFMYPFLPGHVTRPKECKKLYFIQLPKKKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHLLSRYNFEFVDENDNVVAATPGTPLPDHQIPRTKVLAGDSGDGQDEGMTDYPSGEGENGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8F1</accession>
    <name>A0A370P8F1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_79851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8F1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="100"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="43344" checksum="DD62071813F16CEE" modified="2018-11-07" version="1">MAPSLVEDTPLSLRAAPKSTLKTDAGFNKENVIGYGEAYKHENELKGTEKQPPASFPNYLPVWDNETERYPPLQPFEHYDHGKDADPTFPDLLPKDKAEVDDITPTIGTEVRGVQLSQLSKEGKDQLALYVAQRKVVAFRDQDFAHLPIEKALEFGGYFGRHHIHQTSGAPKGFPEIHLVHRGADDRSGAEFLSQRTNTITWHSDVTFEKQPPGTTFLYILDGPSSGGDTLFADMAQAYRRLSPEFRKRLHGLKAVHSGVEQVNNSLNKGGIARRDPITSEHPIVRTHPVTGEKALFVNPQFTRYIVGYKKEESDYLLKFLYDHIALSQDLQTRVRWRPGTVVVWDNRVVTHSALFDWEDGQRRHHARITPQAEAPYETPYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8H2</accession>
    <name>A0A370P8H2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_307826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8H2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="715" mass="80621" checksum="1A46A929C9CC962A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9C2</accession>
    <name>A0A370P9C2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_278872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9C2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="88" mass="9987" checksum="685F67E44C6C11E3" modified="2018-11-07" version="1">MSAFETAAAEVKHLKAKPSDQEMLELYSLYKVGTQSNFAEAPKPGTFDFAGKYKYNGWKRLHDEGVTSDEAQERYIFLVEALKEKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA01</accession>
    <name>A0A370PA01_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_329202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30869" checksum="6054AA0267B7FA09" modified="2018-11-07" version="1">MAPTHAATYKLLTQGSCTEQQYYTNHCIHLDRPREPESHSEKVESTLKEVNTLLLVEEEGREGRLKLLFHVDPEGILHSKRIWHSWGISETGEDQGPELESVKLPIGDSRELGGCSTRNGAVIFFENITGNLQGISLSEGKWTLLEPIACGRQEGSPFGVLRVSDEMVVVFYWHTDKGLHQMTVELQNNVYSDKEVIGTNFLTHQDFMISEEEEPGNYTAFFIVNDSPRRALIEVSPNGERLEASENDWDWQGMFQPITFAVESAEIDEGQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA69</accession>
    <name>A0A370PA69_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_239022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="583" mass="62694" checksum="5C54A6155125E7CB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB52</accession>
    <name>A0A370PB52_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine proteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_285760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016663062" description="Serine proteinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="12">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="180"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="56935" checksum="0DC26E654C8E8CC1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBH8</accession>
    <name>A0A370PBH8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="225" mass="24480" checksum="B1D64E48444B08BF" modified="2018-11-07" version="1">MLVQNDARAAHLIRKPFEAAIDLQVVESIRVLIELFAKNDMHRTEICTGILSRILPHSMELLSFLLSQRGDVNTRHPKNNTTLLHRAAARGDEDALRILISYGAQVSRQSGEQGTALHAAAVGGFHSSVNLLLTENAEVDASCTLTGTPLAAVMARKWKSCCGRYHRSCAEVLIAWGADVDRVDERLGAPIDIAYKAGNNEGVELLLENGALDPKSTAYPLKSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBT3</accession>
    <name>A0A370PBT3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_255393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBT3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="559"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="809" mass="88584" checksum="271A1CA616C13BFB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC34</accession>
    <name>A0A370PC34_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_278433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC34"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK39454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="57778" checksum="3D36B7DACC77762D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC53</accession>
    <name>A0A370PC53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_52382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC53"/>
    <dbReference type="SMR" id="A0A370PC53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF10">
        <property type="entry name" value="CHAIN DEHYDROGENASE_OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="320" mass="34828" checksum="9F09FFB3D8AED0B9" modified="2018-11-07" version="1">MRSVLCRSLSAMAPARSWAPSAMIQPMSQRLHSTGSGSHGSHHIQTRIPSLKGEPKQGHRFREFDLDDRVFAITGGGRGLGLAMAEALMEAGAKVYCLDRLESPHPDFIAAQEHAEKNYGGSLEYHRIDVRDESEVNDCFAEIAGKNRRLDGMIAAAGINHLQSALEHSQVALNEVMQINFNGVFNSATAAARQMFNYQQKGSILLVASMSGLIANKGMTSPVYNASKAAVIQLSRSLAMEWGRHGIRVNSLCPGHIITPMVEQVFQQNPASRAVWEAENMLGRLAYPEEFRGAALFALSDASSFMTGSTMLIDGGHTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCZ5</accession>
    <name>A0A370PCZ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_48003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="28111" checksum="1351C50215E6A63F" modified="2018-11-07" version="1">MTRTSSLDTQPPAPKQLSANTPEVSTGTCDPRHHPTTSTASSPLSTAAWTGRLKVPSFLYPCQQPIHPITRPHVPLSHRKAYHRQPPEPRQPATPDSSSLSHPRGCSNHITPFKMKPVVSALNAWSCVVISVFAIVILSVLGSLYKSEHPGFTGSEGEPEDGAAVAASIFTAVLVYIVCLISRILTFLDWNGRDKKRNTEEEKRWIANRLINRIGFLRVLRFPGLLAHEGPEGRRYIVELNDIQQHCFANSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDK8</accession>
    <name>A0A370PDK8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016893769" description="Cell wall protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22831" checksum="7CE08C0F389143F9" modified="2018-11-07" version="1">MRFPIITLTLLSTILSLSSTTLANPAPSTDYLHPRGQGTITFLGSILNNGLKILQLDKSVRYFTPERLNDVKTRSSEALQSLDEATATGKSIGHFDPLSSHVIAALCPALKSVYSSMIYAIRDKREELTAAKYKDEMIKTLVALRVKSREFAELVKKIITEPDGSYCLFLEDFVDKRYSKTIDEYKGIDSGGTDGVEEDIWNVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE55</accession>
    <name>A0A370PE55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_295647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF3">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39039" checksum="06CC84D732AFAFF6" modified="2018-11-07" version="1">MSPPHPPPPPAHGSAFESAIKVTPLSSHRYSAHLRDEWCIGAVPHGGYTTSILYRLALVHFAHTHPALYKNSPATPIAMQLSFLRRTATGPAVLKVQDTKLGRRTSTLHVMLLQKPDSGKRKQSQPSTTTTTTTGTEAEDEDLEVKVAGYITVSPADAEEGLSATTGWKISSPAPAAGSNGDGSVNLGALGRTGRDGAWGKFEPEHSKFRKATGQTEFYVPVELSEKERKERKMNAEQWARFRPGGDVNARWTNEALVYLTDMFPTALAGFDNAAEEAAVGGGKGLFWFPTVTLNIDLKTRLPEEGVEWLYSRVYTKKVRDGRTDLDVTVVDDKGDVVALSTQVGLVLSASRNIGSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEQ9</accession>
    <name>A0A370PEQ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_35592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017068892" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="18756" checksum="E64EAD1BF1E59BBB" modified="2018-11-07" version="1">MKYALSTILLTTLLATPSLSTPAPDVVSDAIGVAQTIVSGGESVATNIANDATSIASDIRTGGGAAYSSLTSDAGDVASNAESWGTSVASNARSDASAAASDIRSKASDVASEITSKWESATTLTGSNGQPTSTETVSGKTTLTASTASATGTSASGSSASATSSTSEGAGVAMATPGVGLGLGVAGVAGVLGVMAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF65</accession>
    <name>A0A370PF65_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_303569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="76949" checksum="D06FBA9D56839514" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE7</accession>
    <name>A0A370PFE7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="438" mass="50418" checksum="F41732A596EEDC95" modified="2018-11-07" version="1">MIDYQSAALESVDWRSNYYRRSRISGSVIDDLIPFKEFEEIHLLFKRRVVRQYNEMISCTTIPVTIPKNSPGGLIPKATAKIIISTFLPCEWPNVDPETLTVTRTTGYANTNSVVERPNPNGSDTPHLEPFKVFLKIHGELDGEIEVFEHLVPSKFEEAQLSHEYGQSGHGAKVLGFFQTQDGVFGRVDEYLDARTLVPQDVEDADTRGDVARALATFHAMDTTILKRSPVQAYYDAVTRELGKYHGMDKLKRLAHAGGICLDHLVDYDFVYRLRRVIDKLESIGTKEGWCIHDFQFMNVLVRNKPQAGESKVVLIDFEFVFRNYRAFDIGAHFLQKLFQWFNENSQIADCRPYSDEEKRHFCAEYAKQWNQKTGDSDTGEQVFAEAELGFMLAITFEIHNMLCFMDQDDDKDPLNLLSLDKLYREFTDQYVKLGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFM4</accession>
    <name>A0A370PFM4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF8">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="27751" checksum="62B64D72B27D9B8A" modified="2018-11-07" version="1">MTISTDKKKPALVVVPGASQNPAHYAHLLHLLQSAGYGAFTGLLPSIGAQGEVTAADDADYVRNRLILPLLDVGNQDVILISHSYSGMPASAAARGLGPADRAAQGKSTSVLGQIFIATILPRGGDGLSVIDSFGGNLPPHMYMDKEQNLLKCDEPKPPLFYDVEPTLADAATQTSLSQGLTSFSSPCPEASWNTEAFKDRIAYIHTTEDRAVPYPAQTAMVQATGAKWITRELATGHSAQLSAPEELKKTILELVKQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFX9</accession>
    <name>A0A370PFX9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_284572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFX9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="358" mass="40094" checksum="4BCFBF4364DB1428" modified="2018-11-07" version="1">MMHIWPVRIPRPATENLCCDSPFLTGQRVLDALFPCAQGGTVYIPGAISKFSNSDVIIYVGCGERGNEMAEVLMEFPQPIMKRTCLIANTSNMPVAACEVSIYTGITISEYFRDQGKNVTLLADSTSCWAEALRENSGFPVYLGSKLASFYEQRNGSLSIIGVVSPPGGDFSDPVTSCTLGIVQYFLSVNIPLLYSNYSTALDEYHEKYRPGFPQLRTKMKQLLSNYDDLKQFVQLVGKTALNDHEKIILDVASLVEEDFLQQNAYSSYDQFCPLWKTEYLMKGFMDFYGESQAIISQGYSWAKVKGFSADTWSALRNMKFETPDDEDIVSAKLVQLTLRAEHDLRSAKSSRYMLHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG17</accession>
    <name>A0A370PG17_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_277167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="29949" checksum="31DC4D0646FEA8EC" modified="2018-11-07" version="1">MASILPRVGFRALTALPRATPLPRVSLTQLPRVQPRVQPLTRRFLATIPQEQPRLRLGSTAPNFKALTTHGEIDFHEFIGNSWAILFSHPADFTPVCTTELGAFAKMKNEFEKRGVKMIGLSANDLSSHDQWIDDINEVANTNVQFPIIADADRKVAFLYDMVDQRDLDNIAEKGIPFTIRSVFIIDPEKKIRLTMSYPASTGRNSAEVLRVIDSLQTADRKGIATPIDWQVGEDVIVPPSVSTEDAKKKFGEVRELKPYLRYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG21</accession>
    <name>A0A370PG21_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_302881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="36024" checksum="5980FA741D0D1D06" modified="2018-11-07" version="1">MQQEADVYLESHKQVLKWTKELEFLGYILSEIVDPDGLEQRGYYCHQAADLPAIVDTLEHACFEPGSRLRGVLGEKASRHFRNLLLRSKQIRNIMAHHLPLSDEKRLALQETNQELDQQLQSVISRAASRYDIQQVNWYPDDTEFSGRSNWHSEIISLGSEPPLYQRQKILGTAAVPSNGSKKKKRKQKATKESREAHWIALEASLRRKIGRIQEEQARIMEAKARKLQRLEQTYRQRWQVRMEKINRILLMTKDEERDLKIQRRKIFGEPFGAKLSTDALFILILLALSSPLWLFGLVVRKFGVQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG35</accession>
    <name>A0A370PG35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="31534" checksum="06D31302F83377A5" modified="2018-11-07" version="1">MSDVAALEAEVKEFKLQLETVQSSLQVDPDNTELQSLQTELEELINLTETSIAELKPPAPPVSQPPASAAKDNRAKDSYASQPTYRKPTVEQTDEPSTQTSFSVNEHVLARWVSGDNSFYPARITSITGSASNPVYLVSFKSYGTVENLTSKDIRPISGNDSRKRKADASSGNSSSQSPAPPPPHSSVISAAADINPALANQARKEPSKVSDGPARPAKVPRKVKATRELEAGKMKWKDFASKGKLGRKESMFRTGDGVNARVGFTGSGQQMRKDPGRSRHVYQQGEEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG55</accession>
    <name>A0A370PG55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_302976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="410" mass="46005" checksum="EA679C3BF9E3C4E3" modified="2018-11-07" version="1">MSPKRLIVCCDGTWKDSTADTRQPPSNVTRLTRTLSRVAVVKENGQDKEIPQIIYYQKGVGTGLADKYLGVGVAGIGISANVRAAYGFLVDNYDEGDKIYFFGFSRGAYTARAIAGIVCELGLLTPRGMDNFATVYDDFYNRKLPVYNEDDRRQLGFRDPLPRFTVEIVGVWDTVGFYKPWLFGHWSGEKLEFRNTLLSRKVKYAFHALALDEERSAYQPTLWHLPENAKGQELLQVWFSGVHTDVGGGGHDPRLANITLAWMIAQCTKHNQLSFDIEDYLFDRPPRPLETDTAPWATALGKTSTGSFARTVETILGGKSKRTPLQYRQVGDGDPQSTNEMIHVSIVDRVLSGNGNMAEAVPWPSLVIRNPTPDQEWVLDGGGRLRQMPALRQELFMKGRIRTVHVDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGP1</accession>
    <name>A0A370PGP1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_276864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGP1"/>
    <dbReference type="SMR" id="A0A370PGP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="914" mass="101159" checksum="21641EA326897013" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHA9</accession>
    <name>A0A370PHA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_28201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32514" checksum="7AE61759C9592C72" modified="2018-11-07" version="1">MDYTIIDYVDCRGQPEKFYQEPVGTSKRIKPVFDIRFFQSAYYLDGELAGAIAGTIKLNITDQRTLVVCGIMERAYPMDTRAPATQSTTVEKEMDAELKPTSDEKKMYRENPQDETAAIGDDNHSVQDAQAPSDGQSDTDLEAMPQPAFQEESSDQGEGSREKPRVYIVPQLRAKDKGRGRAKGILRKPGSENAELESDDDQQDRADFNERMNPFIYTGDRPNPSTTWVWVLAERKVGRFFRSFRFKRPINWDAAQSRFMNGLLLLRLPVIVGPKKRVRFKLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHQ8</accession>
    <name>A0A370PHQ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_29085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHQ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="31648" checksum="61E2BFDA89BC603F" modified="2018-11-07" version="1">MLPCDEEEQDRLDLFHKLFTVARVSASLIYAPHPRNGRILDVGCGTGIWAIDVAHEYPDAFVVGVDLAPIQPPNHPNNCQFYAPFDFESPWPLGEDSWDLIHLQMGCGSVVGWPSLYRRILRHLQPGAWFEQVEIDFEPHCDNCSLDGLALGQWYQYLKQATQATMRPIAHNSRDTIRALEEAGFIQIDHQMMKLPLNPWHHDEHERKVARWYNLAFSESLETLSLAPFSRVLKWPLDRIRHLAAEAKSEAFNKELHAYNILHIYQARKPGGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHX7</accession>
    <name>A0A370PHX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_276521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="32041" checksum="48A36A3985CDF7FB" modified="2018-11-07" version="1">MAGVCASSLKLSLPNVLRNALRSEFASDVHQGPASRRILSITPFSQSRYKTQRRNFSASIKPQLCQSAIYLSAQDPSLSASFSSNTAPLGGSENEIRRASTEANASPEPNDTKTSHADYLAEAPSSDTPTDKKRTKSSRSKKRSRHEEIPSNPMPQKKPEKWQLHKQALKEKFKDGWNPSKKLSPDALEGIRHLHAVAPEKFTTPVLAEEFKVSPEAIRRILKSKWRPSETEIEDRRKRWERRHDRIWGHLSELGLRPSTKRTRDLTDANQLLYGNNQKKGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHZ1</accession>
    <name>A0A370PHZ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="116" mass="12595" checksum="0E12FE093039D0AB" modified="2018-11-07" version="1">MSDTNLMDIEPGGENTQYESIRLYTETPKKQTGQLGGHSQHTVSEMRTTLGDDRNENEDQYRDTPLARQLEKGEATTGLTGITDIDLKPETPEEGAALAAKIRREQGYGPGSGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI04</accession>
    <name>A0A370PI04_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_336676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32059" checksum="D42725229D72512E" modified="2018-11-07" version="1">MSTTKPAWYETSVTAIDPAAQSMLENYSGLTPEEIIPHVLALRDEAFRIFPYPCIGQMRFLSCHLSRLPFYPQVLSRLRASPDNGFLDAGCCVGQELRHLVYAASIPPSQIYGFDLEPGFFELGYKLFRDNTDSFPATFVGADLGVSDEEWESSEIVGTMKGKIDVVWAGSLLHFWDYEGQVRGVKRLIGLTRGQIGTVVCGRQMGSTVAGVYDLKGFTEKTMLHYRHDVGSLQGFWKEVGEKLGMKWEVQAELEVGETTLKMRNKASFMDDNARIIWWCATRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIA0</accession>
    <name>A0A370PIA0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_21799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="180" mass="19775" checksum="35F8CD8465277172" modified="2018-11-07" version="1">MAPTTPLRPSKMPAPSVRPLSQLTPFEQLVHSYSTGPPTLDKNEEAWDFFPDECNLRFESATQDPPARVSYLLKVIPKQCNYLQNLHGGCAATLIDILSSTLLIALSKPGLYSYGGVSRNLKTTYIRPVPAGTEIRVVCELVHMGKRMALLRAEIQKLDGSVCVVAEHDKANSDPADIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIX4</accession>
    <name>A0A370PIX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_266775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058677" evidence="3">
        <location>
            <begin position="24"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="61530" checksum="BFA13485B02BCB8B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ49</accession>
    <name>A0A370PJ49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579978" evidence="1">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="184" mass="19927" checksum="59F70C6C0D664C53" modified="2018-11-07" version="1">MQWTNFLCPLIALQASLSAARGTHAKRGSETNATLLAYGQNSSAYPIAYGLSDGLLYIAQDPENTAADLTPMTWDLPSITDECWIVNGTFVNGTRAGSLYIRPESDNCLGVLPFAQAEGLNGVVTGFGLFASQLVYNNDTQLEAQFWASKTDNEDVYKLVWVEDSSQIASESFPVVVKASEDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK00</accession>
    <name>A0A370PK00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_17034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000067">
        <property type="entry name" value="t-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000019">
        <property type="entry name" value="t-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="206"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="34477" checksum="677618D14551D4DE" modified="2018-11-07" version="1">MSYGGNQGGYGQYNPYGQQDANPYSDANAMEQGNGSYEMGSYNQPADATTLLNKCREINDGIADLRAKREGQLAAAQNALLDSSTGKEDQVARQTLDYIEDEVNNGFRYLRDLLKKVKQTPGSGDSRVQTQIDVTSRNLRREIEQYQRCQSDFQKRLREQVRRRYEIANPEASPEEIEQGVDNVLLGQEQSFQVTGSRTRQANDARQAALERSAAIRKIEQDMMELGRLYQEVAELVHQQEPAVEQINQDADNVAQNVSNANNQITEAIASARRARKWKWYALLVVILIIAIVVGVAVGVTEANKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKB9</accession>
    <name>A0A370PKB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_335436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="58355" checksum="381F51EB89EE1106" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKN7</accession>
    <name>A0A370PKN7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="98" mass="10383" checksum="C0E7FE7B5F3FDD5A" modified="2018-11-07" version="1">MPNPSLSYGNGMSSGPKSRNVAFLTMFAVISGALLTFRMQSPSKEKRFSPEGDQQAVDGENKLGRSMFVSDGDREAVKGGKPGEPKVGRAPHEGLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKX1</accession>
    <name>A0A370PKX1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_318973</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="1157"/>
            <end position="1232"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1390" mass="153303" checksum="9137FAC5D056B3AC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL26</accession>
    <name>A0A370PL26_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <end position="199"/>
        </location>
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        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="199" mass="22822" checksum="EDC295CE11DBAB2D" modified="2018-11-07" version="1">MLVVLATALLALSGSFVSAHGSHPDQPPSSDWATRHMQEEHHIDAFDAASFFSLHDYDESGAWTPEEVRKTYGMDDETNAGATEDRKSQALREVFTLFDPTNTGFITRDNWMRIIAEGTRLPDLGFGPGHHGDIEYEYEIHHFEKYHGEDATEEELNHPEDIEHFRRHDEEDLAMERLEQLESMQIVEANIPQKFLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY7</accession>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_153762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114689" checksum="9E9A73BD3829DFCF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM39</accession>
    <name>A0A370PM39_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_292432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM39"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="496" mass="53468" checksum="FA163909671A4722" modified="2018-11-07" version="1">MDPSYKARKEAFVSDLAGGSILEINAVTLVAPAAALLWSALQSRLSFFTPYSAAALVTDFLLNVLAILFATTVYSSAPWTLNVLLIAPALLLFLNSKPPRSQQKAKPPPKPTQSDRNAADMPESLPIHPFLTTYRAAMMIITCVAILAVDFQAFPRRFAKVENWGTSLMDLGVGSFVFSGGVVSARSVLKGRSNGARKTPVGQRLIASTRHSVPLLVLGLVRLYSVKGLDYAEHVTEYGVHWNFFFTLGLLPPFVELFDSLAAIIPSYEALSLAVAVLYQAALESTELKSYILVSPRGPSLLSKNREGVFSFLGYFAIFLAGRATGIRIIPRGTTTQRSPQQARRGVLVTLGVQALAWSTIFILNSTYALGYGANIPVSRRLANMPYVVWVSAFNNAQLFLFCLLETAFFPSVHRASGKDGEADRVSFATSRILKAFNRGGLAIFLVANLLTGAVNLSVPTLDVSTAQAMAILIGYAAALTGIALGLDRANIKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM71</accession>
    <name>A0A370PM71_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="19">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_292460</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="19"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM71"/>
    <dbReference type="SMR" id="A0A370PM71"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653910" description="alpha-1,2-Mannosidase" evidence="20">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK43287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="56059" checksum="99EC5F9751D811B6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN37</accession>
    <name>A0A370PN37_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_283259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67752" checksum="AC54D3F9E49B4B32" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE4</accession>
    <name>A0A370PNE4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_264629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="186" mass="20454" checksum="C4A2198876E64A21" modified="2018-11-07" version="1">MPFPTISNASLFEDALQSNEAIEVPVGAVDFVSFTSGQPIRTIGTRGLNGGSAVVLVSTKGAILANVPLFTYNMDEPNAGLAHVWRRMIDFLNLYNKKKGFFMDPDEKRAAIVCRLSPSHTPSSQYNTIFESVLSSTLGVIAKPKVISYLFEEGGHSQPDRGSVFIDGRNEPPKVYVEDADQHWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNR6</accession>
    <name>A0A370PNR6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_250371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNR6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55110" checksum="74828F3A6648876E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNU0</accession>
    <name>A0A370PNU0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_146196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNU0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="42064" checksum="5F7660A566138C78" modified="2018-11-07" version="1">MTLHQQRVQGAYGVSLIPLPVLANKYARTPSPADQLQLFFKKATGWNDPFSSKGATFVSICWMTQGFISSVAYDCLPEFIYHVHIFLAPSHQLLSLSFPRSKPHHQRVLSPRQQITRTMATIIQQSPQEASCFWRSSSDTWTSNHVWEPQERRHSMDDEEEVLYELDEVALAQLPLHLQHNMRQLQLERIRKLLHDRDPDSALSPRPVHPNPYAQTWFKNMMARLSADQEMNEVHEWRQSVHLDGDPDDTTWRLVPRQWTGNRQHHDRRTWHFDHATSGEDSFNAYSIGSTRVCSLHGLGVNEFGFRLSETGSHGSRDQKQEGRKVSSKPRKRNVSLITHMRAHVRFRVRKSVQKLSKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV9</accession>
    <name>A0A370PNV9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_146677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="275"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="789"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="841" mass="91730" checksum="ECAEEEE7EA96E7AC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP94</accession>
    <name>A0A370PP94_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_249056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39736" checksum="3B163909B7667DDC" modified="2018-11-07" version="1">MSTTARADFEAVFPSLREDLLNYAKQYKLPQNALEWFEKALNVNVPGGKLNRGLSVPDTGLALLKKPLTDEQFKHLSLLGWLTELLQAFFLVSDDIMDGSITRRGQPCWYKHEGVGLIAINDAFLLESGIYIILKKYFRSHPAYIDLVELFHETTYQTELGQLCDLITAPEDNVNLDNFSMEKYMFIVTYKTAYYSFYLPVALALHYLQLATPENLRQAHDILIPLGQYFQVQDDYLDAYGDPAFIGKIGTDIQDNKCSWLVNQALQRCNAEQRKVLDTAYGRKDAELEAKVKALYKELDLEKIYKEYEESVVGEIRTKINSINESEGLKKEVFEAFLAKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPC0</accession>
    <name>A0A370PPC0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_334873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="179" mass="20064" checksum="E3C0E775062DB05C" modified="2018-11-07" version="1">MADGLNEARALRVAEIINDYRTLLVHISQQNVQIPSAEANEEGYKTIREGLAAAQALMSSNYNPSMTPAQSNVETEKAELQRVILDASARRFQAHRIYLRVAAARRWAINRQNILRGQQPGPQHAAQLKTVSNTFRQEMAQVTDQYVVADLRAADTRAGHWLADDPSLPVILTWIRSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPG5</accession>
    <name>A0A370PPG5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_150629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40449" checksum="D0D47989115F5C38" modified="2018-11-07" version="1">MSLSHIFRPALRSPRIYNRRTPSYILSPSCPSRRTYASQTPGNPVMEIFNRKTKHLQKDRAARNVEESRKTDYIKDEVAMRLCERLLDIKRTFPQVLDLGANSCNIARALTMPDPDPDAPNGSSPPLSTRIGQLTCVDTSEALLYRDADEPFNDQISLKRQIVPDLETLPFPENSFDAVLSSLSIHWINDLPSLLAQVNSILKPDCPFIAAMFGGDTLFELRTSLQLADLERRGGVSPHVSPLADVRDVGGLLNKAGFKMLTVDVEDIVVEYPDTFALMGDLQAMGENNAILHRELGPISRDVLLANEAIYRELHKEEGARGVPATFRLIYMIGWKEGEGQAKPLERGSGQLNLKDLLGGGSIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPQ3</accession>
    <name>A0A370PPQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_264789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="202" mass="22077" checksum="5D0E9DAE136C0521" modified="2018-11-07" version="1">MDNVTESTDSTAESKKLAQASPCVVTTDQASPRQSESNSAIDRSNDGLYTCWSTYTNEGHIASSSTEGILTRGLLDPDSEEGSPSVSSASSHYGAVVSTHRGILPFFGERTESEASLRSDYYDDVSKEEPEGSEFGGSEFDDMSYDNDDWSRSGDGDSEEWEDSGHQELEVNSHLNERFSRVVRSPPMRHSRPLSGQGKRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ82</accession>
    <name>A0A370PQ82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016812493" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47887" checksum="D13BE338771220C4" modified="2018-11-07" version="1">MILSYTAGLTTLAGLALLAQLASASELPLPILKDFDDTGVLGGLYRPNTTSPRSRIAIYIMHAEQDYTSFVGCTELQERGFTVFCANNEASKSGYMSDINFEDMMLQVNTGLAWLRNQTDIDKVVILGHSGGGAMMAQYQNVAENGVSACNGPEKIYPCSNALAGLEPADGLMLLDANYGISTMGLLSLNPAIEDETNASRLNQSLNIYNPNNGFSNGTQSNFTSEFKKRFTKGIVARNNRVLEHAQNRLKEIEKGNGMFGDDEPLTIPAALYLGPNNLFITQDVRTLHHTTYPWTLLEKNGTTEQVIHSVRVPSGWVDVSNSWEQAALKTTVRRYLSTLAIRANENFNILADNLEGIDVPLLTVGMTGHYEYLNAEKIHLNAIKSNDTSIAFVQGAQHGIYTCTECESYPGEFGDTVKTCFNYVAAWLSERGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQI3</accession>
    <name>A0A370PQI3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_313250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486794" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="15">
        <location>
            <begin position="376"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="56789" checksum="AF724F78DA4E077E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW9</accession>
    <name>A0A370PQW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_142075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="301" mass="35451" checksum="4A1D5A25BA642656" modified="2018-11-07" version="1">MTEVSSTRLYLGNLPRNVTKQDIEEHFSTHGSGKITEIKLMNGFGFIEYEDAMDARDVVPAFHGSDFKGERLTVQFARGPRRKENFPGPMDRPNMPRPRRTIFRMMVSGLPETSWQDLKDFARQSGLDVVYSETGRELGRGFVEFETANDLKTAIEKLDGREFKGSRVTCIADIQTYPDERAIRDPYRSRSPRRSYPPMDEYDRRFPAPRGYSPRAHYRERSPIPIRRDYYDRDGYGRRTPPRPRMEDYPPPRRPYDDPYDVRPPPPPRHYDDPYAPPRPYGRPRSPPRGEYMPYDRRGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQX4</accession>
    <name>A0A370PQX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_142279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="16554" checksum="DF1C58BCB08C338C" modified="2018-11-07" version="1">MGRHDTWSAVSPFCVCWLELIAFPAPFVVGRFKGLIVNLNHSSGGATQSSLAGTLDLPSYSESRNVLEAVWKPLGGGSKLPHLPYRVRSRSTGLKDSEVWGPSSTSPFRFHLLEHDETVLVRSTTPDYGFHLIIPRNGARLLTQGRQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR53</accession>
    <name>A0A370PR53_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_274960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR53"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="51997" checksum="9C417A56A8340055" modified="2018-11-07" version="1">MATYALSPAHRNQMEVSLVDSDPEIAQIMEKEIQRQRESIVLIASENFTSHAVFDALGSPMSNKYSEGYPGARYYGGNQHIDAIELTCQARALKAFNLDPAKWGVNVQCLSGSPANLQVYQALMRPHDRLMGLDLPHGGHLSHGYQTPARKISAVSTYFETFPYRVNLETGIIDYDQLEANAELYRPKCLVAGTSAYCRLIDYARMRKIADKVGAYLIVDMAHISGLIAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTDPKTGKDIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQVDTPEFKQYQQQVIKNAKALEEEFKALGHKLVSDGTDSHMVLVDLRNKSLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGAPAMTTRGMGEEDFKRIARYIDQSINLCKKVQSELPKEANKLKDFKAKVASETVPEILSLRKEVAEWASTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRR1</accession>
    <name>A0A370PRR1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOPA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRR1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22217" checksum="71E7446DD737B3B4" modified="2018-11-07" version="1">MTDQFAYSYPSPLEGYENLEPLPDERNEDGKSLRNPQHGVLSKAYEEFPDPLTKGRRGGFDIHIYHFQNNPDQVAFAKALWERIRREFPELRIYQFFDRPIGPHPVAMFEVNLFTPAQFGAFVPWLVVNRGPLSALIHPNTVETEEERNHTQRATWLGERIPLDLRLFKLMKEAQKRKELEAEKAAAGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRV0</accession>
    <name>A0A370PRV0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="175" mass="19435" checksum="1E1A978947DDBAF9" modified="2018-11-07" version="1">MRTLAIVGVGQVVSEVEEGELSLSIIRTSAKFCRSQKFVSKINHIRGFYFRLGTGNLENATIKPGEDEEYLPGEKRGAERAGQGQQQPDEPVVSSAEDPCCLRNAGGLSHSTSLYDFADELMQNMTCMDEDLSTSLDQQTLNMLKEVAIQKVQKLMVNNRSSSAFQSGWHPKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS22</accession>
    <name>A0A370PS22_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_274281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="386" mass="42683" checksum="7BBA504FC8505229" modified="2018-11-07" version="1">MAPHNIRWGIMATGWIADVFTRDLLRDPNVRNVTDVSHTVVAVASSSNAARAEKFISDTGIPSPCAAYGSYEDLVADANVDVVYVATPHSHHFQNVMLALNAGKHVLCEKAFTVNAAQAKILCETAQKKNLFLMEAVWTRYFPLSIQIRDLIKQGAIGEVLRVISDNSFGDPVEERWGTEHRMVNKDLAGGCLLDLGIYSLTWVFQTLYHTLPRDQRKPPSAISAHMTLYHLTGADEATTILLSFPTSTPSNLPHPGQSQAVAMTHLRVSTDPDEANTARPAIRIQGTKGEIQVDGPAFRPERYRIIPAKGEGEVKEVECPFPGGGKGMFWEADEVARCLRDGKLESETLPWEESIVIMEVMDEVRRQGGLTYPEKIESTVYPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS84</accession>
    <name>A0A370PS84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_274098</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS84"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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    </dbReference>
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        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
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        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
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        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
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        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="61"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="511"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDK44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="646" mass="70714" checksum="B84C9F69CC1F271F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU13</accession>
    <name>A0A370PU13_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_281836</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK45688.1"/>
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        <property type="reaction ID" value="UER00107"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="AAK_NAGK-fArgBP"/>
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    </dbReference>
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        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="357"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK45688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="908" mass="99216" checksum="29EA727724133FC8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUC7</accession>
    <name>A0A370PUC7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_123685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK45798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="44300" checksum="1B6D1B747BA02A5A" modified="2018-11-07" version="1">MGTALDALNHQPLNSRRPAAPTLPSFELPAPNFQTSVKYAHHNPPPINPSVSNLLTPPATTQSGETLPATTSHTATTTAPTNPELAPYWQSQSAYQSGSGAAAARQSWNSSVVSYPSRDTFSPSVNSLNRNPATSTPGTEHITQPYEMNHLPPFHQSASVSTTAPVQAGAPQQHHAMTHAMLSAHNPLPNPAPSPHPLPSNDPYMVKSSSAPAYGTIQQLASPPGGYSPYGQQGIVPNRVASNPHPSHHLNYQRQPWPSYSLPAMNGPIWTNVHNPNGQMSLTGNLQSGVLPGLPGYNSGHVANMQQMQQLYGGHPPHPGHGAPGPTNDRPFKCDQCPQSFNRNHDLKRHKRIHLSVKPFPCTHCDKSFSRKDALKRHILVKGCGKDGSDGLKPGEHGVKEEDRSDESNGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUX5</accession>
    <name>A0A370PUX5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016761528" evidence="1">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="217" mass="23190" checksum="401A35C9B4642A97" modified="2018-11-07" version="1">MRFLQILASSLAVGLAAAATPSSFTPSVDADVGVVFTKDGSHLTLTSGALINQNWTINIPTLYLEDTTSTDDEYVIIMIDPTINEDGVSTAALHWYQPYLAYSSGVLEISNKSAPNAEYVYPTPLEGPAHDYILLLYSQPEDYSLPDCLESLLPATDAARLGFNIDEFEEVTGLGTPVAANWFQVVNPTPATTTYAITSTLVSTYACEATATATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV21</accession>
    <name>A0A370PV21_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_332673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="52323" checksum="EDAB9C852462AF5C" modified="2018-11-07" version="1">MAESSNSAAASGPAQSAASTSAPKPSNPAFRMLGMPNLRMKLPSRNWMIFFTITGSFAAAVIYDRREKRRAQQKWSDLVAHISKEHLPIEQTRRKINVFLSAPPGDGIRVARDHFKEYVKPILVAAALDYQIIEGRREGDIRAGYAERIRKWRRKAGEPSTVVEDPTVEDVVFAARTQMGVIEEPGPKGDLVIGRHTWKEYIRGLHEGWLGPLDPPPPPPATEDPAPVESSTPAAEAASETKEGDANAPEQEKKEEKPAKPVGPTPAYISTSDYSSQPLPRTIPQTLSGSVPIAFPHILGFLNTPIRLYRYLNQRHMAESVGRDVAAIVLASYSRPYNTGSVSSDASPISDDTLGSTTYEQQTVLEEEEKEWHKSVHRKDEANPDKEREWLDDIVIDPRLASRMHRYSVSPEEEARAQRILEGQEYILGQERPVPVSFWKRMWVKYGYGEDEETLRRKPILGNLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWD8</accession>
    <name>A0A370PWD8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_324183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="148" mass="16663" checksum="CC8129CBE02E4E4F" modified="2018-11-07" version="1" fragment="single">MSPIPSYSRPGRGQHFQDAYGFAEACIAGDRMEIAGQTGMSPTSTEVPPTLEEEVAQAFNNINEVILYTLEKTKPDLRASVKSGWDRVVKIRTYHVQLPQTREKIISLMVENVKKWCPDHQPTWTMLGIEALPFEGQNLEIEVDVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWI9</accession>
    <name>A0A370PWI9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_246434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWI9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="918"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122493" checksum="529C3B2E782814A0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK0</accession>
    <name>A0A370PWK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_229292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="53162" checksum="11DA3181E3A91B1B" modified="2018-11-07" version="1" fragment="single">MSNDLPFVLDDPSLLHEASLLDGKWVQAQQLQSFPVEDPGSGQVFAHCPNNDLSDVDRYVESAQTTFLKYRDTNPRERAKLLLNWHSLITNSRSDIAKLIVHETGKPMTEALGEVDYALGFAWWFAGEAERVRGSVAQPSVSNRRTLVIKQPIGVSIALVPWNFPVAMTIRKAAAALAAGCTMIIKPSPETPLSILALADLALRAGFPPGTLNIITTDNDNTPAVSERLCKHPLVRKVTFTGSTAVGSIIAKHCSYGLKKVTLELGGNCPFLIFDDGDLDQALAALMVLKWRTAGQACTHANRVYVQSGVYDTFLSMLVNATKKIQVGHGAAPNTTMGALTTTRGLEKLERRIADAISKGGKIVCGGKRLTNLPGNFFAPTIISGMTPSMVTSQEEIFGPLLGLYRFETEEEAVRMANDTSMGLAAYFFTKDTSRTWRLLESLEAGMVGMNTGNASAAESPFGGIKASGYGKEAGKDVAIEEYLISKTGTLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWQ9</accession>
    <name>A0A370PWQ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_104334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="138" mass="16058" checksum="3DCD50390A5A1D2B" modified="2018-11-07" version="1">MEWGCQVIAHPAEDTFDASAEDGQIDAEMDTVEPSGESRPPEKFKHWKRISNLRPVHVAAESNNASVGNRTEDAEGQFNHRKRRSMLRLKMTISISRWLRLSYPVRTSRRTLVLRLRRWMTWACRGRRHRALPLPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWW4</accession>
    <name>A0A370PWW4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_227531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="281" mass="29777" checksum="F678239B83D50E1D" modified="2018-11-07" version="1">MAGTRLNGGIALVTGAASGIGKDACFALAEAGVEAILLADLNLPTETTLQECQKFASHPKFRALSVVVDVTDEASVDNMVQRAVSELGRIDYCVHSAGISGNSRTRTATLNVDAFDQSMRTNSRGTMLVLRAVSQAMSLQEPRSYTSTRSNTTRSLGRGSIVVLSSINGLISVPGMMPYTASKHATIGIAQTAAVDNFEHHIRVNIVCPSWTDTPMMQKTISNVPTLEQAIAKLCPLGRIAMPEEVSDAVVFLCSPAASFINGESLVIDAGFTLTGFRMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX93</accession>
    <name>A0A370PX93_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_332125</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX93"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="107"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="494" mass="54329" checksum="266EEA5260E8D9E1" modified="2018-11-07" version="1">MAKEKQLSAQQISQHKTPDDCWIVVDNQVWDVTDFLEEHPGGSSIILKYAGRDATKAYSEVHAPSVIKTQLQPERNMGVLDEATISDDWVKQPPTENPPLLLENEKPPLHTLINSHDFEMVASKTASKKTWAFYSSASTDLITRDANKLCFDRIWLRPRVLRNVRSVDTKTKLLGIDTELPLFVSPAAMAKLIHPDGELAIARACGNKGIFQGVSNNSSYPLDDLRSAAPSVNMFFQLYVNRDRAKSAALLRQCSTNPNVKAIFVTVDAAWPGKREADERVKADETLSVPMAPSKAKNDKKGGGLGRVMAGFIDPGLTWEDMVWVRQHTHLPVCLKGVMSADDAILAMEAGLDGILLSNHGGRNLDTSPPSIVTLLELHKRCPEIFNRMEVYVDSGIRRGTDILKAVCLGATAVGMGRSMLFATNYGQEGVEHLIDIMRDELETAMRNVGITSLDEAGPHLVNTGDIDHLVPSSATHPYARMVAKGRRPIGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXR8</accession>
    <name>A0A370PXR8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_227922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="666" mass="75276" checksum="C92E3466FA429178" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY03</accession>
    <name>A0A370PY03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="10" type="ORF">M752DRAFT_317002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="105"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="902" mass="100349" checksum="C88127433F2505C7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY41</accession>
    <name>A0A370PY41_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_323532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY41"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="34652" checksum="F96806351E08933A" modified="2018-11-07" version="1">MSTQDSDAESSISSQTRTKTPKHTFPLAHPPPKSSPCLRLTPRLLLQVQQLSITSNRHRALPILEIYQTPRLGKSLSNCPRKLHGRDLYILQSDAYTDITPKSSSEETTYPIAAGVIYNNTNTNTNTKKPTTTQPQQDNTNTSEEKSDEIYLPTTHQSYTATRTSRGNYRFILRQKNTSGETVILEWRRKTAQGSGRPRTASGSASAVSGSTDSDTIHDNNGKACEEETTNDPSSSDANPRFVLCVSAIGGAAGAGVGADQRVRRSGLAGLEKKGLRVGGWDARQVRFLEEVGLGVGEEVVTLVLTLGVYVGWMEGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYA0</accession>
    <name>A0A370PYA0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="222" mass="24594" checksum="D22452E772021AF0" modified="2018-11-07" version="1">MAQERAPLRLGSVAPNFEADSSNGPITFHDYIGNSWAILFSHPDDFTPICTTELGAFAKLEPEFTARGVKLIGLSANGTESHHAWIKDIDEVNGSNLKFPIISDPERKVAYLYDMVDYQDTTNVDAKGMALTIRSVFIIDPSKKIRLIMSYPASTGRNTAEVLRVVDALQTTDKHGVTCPINWLPGDDVVIPPPVSTEDAQKKFGDIRIVKPYLRFTSLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYM3</accession>
    <name>A0A370PYM3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_228421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="353"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="750" mass="81659" checksum="5A8BB7CABD62470E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ23</accession>
    <name>A0A370PZ23_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored cell surface glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_70737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="101029" checksum="93F6B8F1F8B4C501" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZN6</accession>
    <name>A0A370PZN6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_331444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="253" mass="26898" checksum="E3EA34E0F8168A8F" modified="2018-11-07" version="1">MGQGRLQDKIAIVTGGGFGFGEGIVHKFILEGANVVIVDLDQENGKRVQCALPAGRAVFVQGDVSSDSDWEKVREVALENFKKIDIVINNAGIVHAVQPSLETSETMLDRMYKVNVKSIYHSAKTIAPLFQAQGGGVFVNISSMSSIRPRPKYAWYSATKGAVSAATKSLAAEFAKDHIRLNTVCPVAGETGMMPLILGGEDTPENRSIVLSTIPMGRFATPADVANATAFLASDEASFITGVELPVDGGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZR1</accession>
    <name>A0A370PZR1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_271929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZR1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016859957" evidence="3">
        <location>
            <begin position="20"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="339" mass="37803" checksum="A2FDF8E8CFC38B56" modified="2018-11-07" version="1">MLFRLLSATGALCITTAAAAALPAPRLQSTTGSHQINLPAIPCAFSDSTCTESFDSVSQLTIDFSTQNGTLRANQQPIFPATVPMQFTADRKWESFVQPVQVSYSLDVRPLPARPGADLGDIYYLKLRLFDQHGQAATQNSIAISLIRDAQGGLQLAMIDPNGSRDYGHGNRVWQMKAWKEQLETYYNHAKEAVKNCVKPEHPKHEHEHEHEHTHEHPHKMVGSSSDSHPHRRPSSNKYYPSSQSGHFFWTGREQSIMKIARPVILPALMGIMAGGVACIVGFLLGRLIISIYLCAASRRQQQQNIPIIRIEEGEPISEKEALLEPYSDQEPETRQSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q064</accession>
    <name>A0A370Q064_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_288298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q064"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009664" evidence="7">
        <location>
            <begin position="18"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="505" mass="56124" checksum="CAC9A15445500238" modified="2018-11-07" version="1">MASLIVVIAQLTVLTLASRMVYLCYFHPLAPYPGPFWARCTNLWRFFTFMTGRLHLAEQQLHQKFGPVVRVAPNWLSFSSLEDFDAIYGFNKSVEKGDFYAFGRSPSQREASIFSTKSDTIHRHKKRKVLGPALSSSKVARYEPVIEEHVAILLARLEASRQPAGTAIATANVAPLISRFTLDTMLEILFGSAIASNPYTDSAAAGAICSQLRKMTKRAWSYSLWPIYGRIMNSWAINYLLRSLFYNGDGAQTGMTGLAAAVHRAIMRDPQHVMQSPKPGIVKSWLEVPVDDVNRMKQPEVLAEAMNMVFAGPGSMAAALTAIVYHLGSEEGQVWQDKIRRKGAVSSQSITAATIPLELQAVMKEAMRFQGVFPTAFPRVIMSGAERVIPSLSTPLPVGTTVSANTYVLSRSCEIWGDDADQWIPERWIGDAEHRRQMETKFVAFSKGPRGCVGKDLALIVLAKAVMGLILQWQIISVGSLRGKSWLEMQYDDCWLELRRLSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0B6</accession>
    <name>A0A370Q0B6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_322832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0B6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12725" checksum="F7EA6962D36DEA46" modified="2018-11-07" version="1">MPTRRIAQIVHLKPSAIAAYKECHANVWPEVLQQIKEYSIFFDNERTLFATFKYVGEDFEGDMQRMKANPKVREWWALTDGMQESPIPGAVGSAEGPGWWKVLDEVFYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0P6</accession>
    <name>A0A370Q0P6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_272212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0P6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="818" mass="90979" checksum="CD83F10DDA4DEE33" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0S5</accession>
    <name>A0A370Q0S5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0S5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="882" mass="97234" checksum="37A7AB20F79F7CDB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0T4</accession>
    <name>A0A370Q0T4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_331767</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0T4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016687789" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="55"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK48050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="657" mass="74601" checksum="C7F0FC8AB14CF57E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0X8</accession>
    <name>A0A370Q0X8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_299893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="324" mass="37673" checksum="E1B6885632D39FAB" modified="2018-11-07" version="1">MIDTYHNAPSPYCIGAVLTIQSHTPPPPFHKGEIFQQIRPHRSLSPLELCLQNPLVPGSDCHNFINIRLIKGLQTGPHKRSQVFVVRCVDDFHSSGLPTDQDMIAKFYDPLYHDRDDGNPFRAADYDYSHECASYKHLSELQGSAIPQFFGSYTFKTEIDGHPRQVRLILIERVNGLPMSRLEPKRFSTEERQDIMKQIVEAESALYAKDVLHEDLCPRNILIEWSGLEKVRVVIIDFGKSVIGRSRNPSNSEEESQWFPGVPISPLLRWNIYYGYPNSFEDWIDWSWQEWLEFQYKETESAITDEQRQMWPVYDWMLEIGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q144</accession>
    <name>A0A370Q144_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_11191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q144"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="38041" checksum="DC67824F4206CE60" modified="2018-11-07" version="1">MAPKLLFLFEKDNDRYWLSDATGLPIADGCPLLDLKDKELVYETELLIMVTSAMEAKLVPANYNYLASYKIAETYYVLLEERIDGGFTAISPSSNSATLGDGDSAKSDDETPTTRRPPTYSLSDGEDNDCTDSDIVNPSQSTTVPSASSHDGILTPSQSTATTRAFSPADVDRSDDPKRDGVKISESDGLSPANKTVPSTEKSYKTPEIASDYGSDTDGDPIDSGRRRRQPIITEVPPREPPSQPATDFFSGMASTDYTWGGIDASGCNIEFVPDQESRSNPIRVGPGPEIPSGSDPQSKTNHFTPSTTRKPLPYPPANNGLPTSRATPYYTKWGWYQPPAYGPTNPFGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1H3</accession>
    <name>A0A370Q1H3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_331965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1H3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="495" mass="53463" checksum="127E8727C31D91E7" modified="2018-11-07" version="1">MTIASDQPETPSETTSLLSGHNESPVQPKSVTRRAQRVLFLACLIAVTVDIGNYISVAPQLQIYELNICQRLHPEVFDNTPGRGLPSVSPSACKAADVQGELALLKGWMSTFDQLPSIVLALPYGLMADRVGRIPVLFLSLAGAVLEEMAIRVIAWYHATIPPRAIWFTPIFQILGGGSQITTSVAFTIIADVFPIEKRSNAYFILSASILLSEIVAVPLSAWMMSSNAWIPWMLGLACEIGSLFAILWLPETKPAPSINTVNDVQPETAGHSKRSSAFTWTSVVHFARSQIAQLHEFICEYPGALVISIAFFFSSYGIEAVPFMLQYVSKRFSWSLAEASLLICVKGIINCFALMLVLPIATKILDRYLSPVQRDIRMALGCACLLMAAFVFMCVASHPAVFVVGVALVAFGGGFYAALRSVGSALVGPSHVGLLNTTITLTQGAGLMISGPLLAGLFRIGMAWEGVWMGLPWMAGVILFAATILTVYCLQVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3P6</accession>
    <name>A0A370P3P6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_280370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3P6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="272" mass="30682" checksum="455426223EDC644B" modified="2018-11-07" version="1">MTSERENKTFLARLCEQAERYDEMVTYMKEVANIGGELSVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEQHVSIIRDYRQKIETELEKVCQDVLDVLDESLIPKAETGESKVFYYKMKGDYHRYLAEFASGNKRKVAATAAHEAYKNATDVAQTDLTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGNEPEGAAPKEDKPEEETAAAPEDKAEEPKPAAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P498</accession>
    <name>A0A370P498_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_260059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P498"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="344"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="50826" checksum="D9111EEB58AF9E70" modified="2018-11-07" version="1">MNVWSGTISLDGGTQLQGLQLIDRSSNWQPDIGKDSALSLRCFVNPSLIPLYARCGPNLEVHTNSPQTSQWLKDKLTGTIWLEEDDLDRLQTLQCPIGLLVGIDNDARTKTSEANTTDLLIHGMLSTTTSYERPPTPPVSSPELDHQPSQVIRQELRIYATPISARLIAKTQSLPSPQDTDGHGRSPQFLPDIRSPSPKRRRVATLFESVAQHHKRVRQKGGEAVSQLMARSLSQSSQQLQGLRVKRESEEPSLPQLDRIASQRSRSVSIGANLNTKLLEARSEQSRPSSRRGYVRELNSRRGTPNPFVESSLRREKELSPELPSEGKLESPTAPKDADTIIAENKNTITRTILTCMRLYGFNRATARSASSSRPQTGTGSHDMITANDEGFSNTDEDEFKAMYHATYRASTFALRKYLKEPSSGENDSPNKPPLLEKGKAMTYIDEFLKLFCEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5F2</accession>
    <name>A0A370P5F2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylamine N-acetyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_270976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5F2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="324" mass="37072" checksum="DA93E0EE39B0F7E1" modified="2018-11-07" version="1">MSYTPAQLAQYFERIKLPDDIRARLSAGKKDLEVLTSLVRHHVAGVPFENTVLHYTPEQYFELKPQGLHEKIVRRRQGGTCFQVVRILSEVLLSIGYTLYNSAARLNAAASISLATTADPNRPVGPQFGDWQHMVLIVRIDGQDYLVDGGFGPNCPVQPIALRDGYEFVDGRLGRRGRLIYDNINKGRAHHLKYWRLQFQSMKSPVAPWMDVYAFKECEWLDTDYEAGARAVGTNKRIWFRLRVTAFRYVLEDGVPVGWVMLWHNTLIRFHGGKVLEKSFLESEEDRIEVLADMFGIVLTEDHRKEIAGMFSALPSKRARSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R3</accession>
    <name>A0A370P5R3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_224650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="566" mass="61701" checksum="86431BF31E101633" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5U4</accession>
    <name>A0A370P5U4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_92848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5U4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14654">
        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="11"/>
            <end position="41"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK37214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="671" mass="75451" checksum="09BAA2B0801D1CC8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P623</accession>
    <name>A0A370P623_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="214" mass="23823" checksum="3ACC30188E4360CB" modified="2018-11-07" version="1">MFHLDTVTAAMRLLSSSYQEQPTNDNEWKSETPSYNRQYSQFDARDHGTVGRPNGLQNRTLILHILSVSNCRSIFIPAQSDSVIVSGNRGIDGEYKVTKFTLINHREREREGERNQTDTVIRAPHLVLCMNRASITPPNYGQASKAQLSPSFINHHSPATENPAQHLPKTAENQSTTIPTWNPANPMTNKSAVPRVLAGRAERVDVDHLVAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6F9</accession>
    <name>A0A370P6F9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_321815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="196"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="393"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="983"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1159"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1598"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1776"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1555"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1702"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1725"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1798"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1810"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1852"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1914" mass="202886" checksum="6FA40020B4138A09" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P756</accession>
    <name>A0A370P756_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_258393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P756"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF15">
        <property type="entry name" value="DEHYDRATASE (PRPD), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="295"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="483" mass="52606" checksum="29CD9ED53EB541D4" modified="2018-11-07" version="1">MTVIPAADDNSRKPYDAVIQAIVDYVYDYQIATDNAWARAKVALMDALGAALESIHTSPQCAQLVGPAFPIAPATSGLFRLPGTAYQLDILKGAFDLGAMIRYLDHNDAFPGAEWGHPSDNLGAILAVADVRSRVALAEGDPDSIVTMQQVLEALIKAYEIQGCFQIKNAFNKVGLDHTILVKIGATAVSAWLLDLPREQALSAVSHAWMDGHPLRVYRQAPNTGPRKGWAAGDACMRAVHLALLAKAGQPGANTVLTTPRWGFYDVLFKGQEFDLPQPFGTWVIETVLFKVNTAEGHGMTAVEAALEIANTLRARGLDPTKDIQSIHAKTQAAGMTIINKGGATLHNAADRDHCLRYMVAVVLLKGAQVETADYQDDSPWATDPRVDALRQKITMAEDPKYTADYHDMAVRSVANSLTVTLTDGTTLPEVLVEYPLGHVRRSETPQEVYAKAERNLGLRLSTDRVQQILKTTSDEYVVYVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P777</accession>
    <name>A0A370P777_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_286984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P777"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="46116" checksum="DE686A161221FB22" modified="2018-11-07" version="1">MTEEQGPICVASTRQEGDEHCPGFASHSLNSQDSTSLQSNEKRSLGQNPNTTYFKGAEWSADGTTLLTDSSDHHIRTWILPPDMLEDTASPCGLSPYSVLPSAEPTYATAMYPFFSLQDPSTTLFLSSVRDHPIRLTSALAPTSVATYSLVNPMTEAFITPHSMIYPSALGGSQFLTGSDSLICLFDVSRPGNDGPVTSMPTIPSKRKQQVGGGVGMKGIISAMALDPTGAGILAAGTFTRHVGLYGAHGTGESLGTFSISKTEAHRHIGGRGITQLLWSPCGRYLYVAERKSDGVLVYDIRVTGQLLGWLQGRKAFTNQRLKIDVFPSGENGSHEIWAGGTDGCMRVWQNPTHASGAQDPKWEWKVHNDTVSSTVLHPMGNIVATTSGQRHFEKDIDDASLPPMPDIDNSLKVWYMPLLNANSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7V5</accession>
    <name>A0A370P7V5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_286625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7V5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="430" mass="46375" checksum="A0273AB618929617" modified="2018-11-07" version="1">MTNLTTTSKIRRACDRCHTQKLRCIRSEHERACVRCARASLVCVFSPPTRHRTSPSEAKRLGCSQALNSALHPTNTGSLWSPDSSTLLELDPSAAPLHPGLPCPKPVGMLDPLPAATCDPFTPVEGFSWDHLLNTSPPMALGDLIPGELALTTTTFSTSTSPLSPSHPLQTPPASRIAPQPHSSPPEPTSIANHTEWVAELARLNVKLLTHAQQIAHRQPRETPRRSSPTSAPDHDLDEDRPTFAVDQTFLLSQQLIDLLSQQDAPSATGAPAQSPPPGPPQLPRTLRSLDPASILLVLSCHLRVLESYSQMFAHVQAWQEHGGASLAATGIGLPALNIGAFSLPASSPRLQIAVILQLAEQLLSRLREMVLLPDVPALAATRSLCHEMGASHHSTAMHEVVSITLQAISARELGMTKTIAWIRRSLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P816</accession>
    <name>A0A370P816_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribonuclease TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_338909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P816"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="36129" checksum="784844C4A7968911" modified="2018-11-07" version="1">MATDSEPLRFADVAVTYTADQFQGIYRGKQYHAPDFGEVIQRAKAYNCEKMMLTTMNMEGFHRNLQLVREHPETCTLTLGVHPYHAGEIYASTNEPSYLSQIRELGQSLLREENSPLVAFGEIGLDYEYLDRADKETQIRAFKDQLELAVEFQLPLFLHVRESCADFIEIIRPYLPRLPQGGLVHSFTGSVSEMRQLTDELGLDVSVNGVCFRTEEQLEMVKAIPLDKLQLETDAPWCEVLNADEKIAPFLQKAREMPPVRKHNKFILGQMVKNRNESCFMERVAMVVAGVKGISVQEVAYEAWKNSVRMFGLGVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P837</accession>
    <name>A0A370P837_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_329917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P837"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="49820" checksum="E4383E81A86A2B97" modified="2018-11-07" version="1">MESTASAKAREIWLDGLRGIAAAIVAWFHFTVAEMKAPYRSFWAVPAAENHRFFQLPPFRLLFAGQSMVLLFFVISGYAVSTSIIRLRDDVPAQFYRKLTSSVFRRGFRLYIPVLTLCLISHSAYYMGLIDWMPGDREGCPGAQPWSALRPHLSCLTMTFLTTLHLSGPFYVTGYNFHLWTISYEYQCSMAVYLVILGLASIRPRVRLLAIAGLCVTLLWFGSPILSAFMAGLLFAELDVLREASWNSLAAGEMRKPTNLVRNCANVFTGFLFVSGIYLLCLPQDTTFPPDFWFQSSLELPFYVDPEIRIRGWHAVGAILVVGTLRRVPFLRVPLETRLVQFLGTISFSLYLFHPLFIMVMRNRILQAVCYHLWGTDFWQTQQDESAWHVLFLAWTAAAVVMFPVLILASMYMSKTVDRKSVVWAYQVENLVSRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8S6</accession>
    <name>A0A370P8S6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_256843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8S6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="331" mass="35912" checksum="A9BA8ACE182DD4A6" modified="2018-11-07" version="1">MASKYAAAHKSPQGPGDARPTASQIIKDQNLEDKLSDKTILITGCSSGLGVETARALHLTGATLYLTVRDVKKAEANLGDLANSPRVHFLHLDLNSLDSVRACAEDFNSKSKKLNILIENAGIMACPEGRTADGFETQIGSNHLAHFLLFILLKPTLLASSTPEFNSRVVILSSAAHRISSVHLDNISLEGEYEPWKAYGQSKTAGIWAANEIERRYGAQGLHAFSLHPGGINTDLQRHISQEQQAAWGQDEALMKTFKSPEQGAATTVLAAVAKELEGQGGKYLDNCQIAEPYDPISGTWGPGYAAWAYDVDGERKFWKLSLELLGLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8T4</accession>
    <name>A0A370P8T4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_76481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8T4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053191">
        <property type="entry name" value="DcsG_Biosynth_Enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39217">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39217:SF1">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38017" checksum="E49161F412DF7B71" modified="2018-11-07" version="1">MRPILDTPQKILFLTTQQPHTIRAEWPFYQNYDLPGLLMERGAQVTLKCWMDEDILTVLSQFDVVTFLWCNEYYKHPKKFFAFLEKAEKSVWSLPDAPLSNVPRIINNTKLVRWNADKRYLLDMEQEGFTIPKTKIVDPRKYSVAELNALVHDFLPSKSVVLKPSMSASSTLTRRITNTSTLSPDDLTFLELCTLGGLRSSLLIQKFEPAISTGEYSFVFVGSHLTHVMLKSPQKGDFRVQDEYGGSARLANLLDIKLQSLQAVQNVFNSLQRRFGYKSTEGLSSGEIGYVRIDGLITEDRPFVLMEIEAIEPHLWLETGKGISDMLSLLLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA17</accession>
    <name>A0A370PA17_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="30416" checksum="33CB1B78A3FB6EB2" modified="2018-11-07" version="1">MAANQTLRLFRVHDERNSICAVANTITSSFAQDPLITWLRPRVPPWTKDNTETFKWQYRRIQRAVAEGIVLQSGPSYQIGRLLPPRPSESCLVEADVKGSVVEESRSEDGDEERDAGVVALLFPPRSAQKWSFSKFMLQCKLLFLDTFCARRESGTNVQRLEIMMNSHDKTISRVKKLHKLCDVWYLEVVAVHPSLQGRSLGKKAMAWVLEYINNTPILLECTSESNIPFYQKLGFEVVEEVELMEGGEAVKLWFMLRQVLGSGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA22</accession>
    <name>A0A370PA22_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12151" checksum="D11D4ACE92E6CA75" modified="2018-11-07" version="1">MDAYHHRSAITVCQIKSPLSWSVLAGEYYRRRVCCFSLAVPGTSGSAPANGRILIGTICDVGQSRDPDVWGRVRFFDSSRASMTTAPRGHWNGVAITEEWCVKLLNEHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA9</accession>
    <name>A0A370PAA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_321015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="78"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="45117" checksum="B41C886A5CEA040F" modified="2018-11-07" version="1">MLTRSLRPKGTLRWTRPGLPYRRCLAHVSNVSDLPTVRCSPRPPFSVPIADDSFETYNLDPPPYSLETTKSQLKQLYYDMSLIRRMELAADKLYKEQKIRGFCHLSTGQEAVAVGVEHGISPEDKVITAYRAHGFTLMRGGSVKSIIGELLGRRDGICHGKGGSVHMFTKNFFGGNGIVGSNVPLGTGIAFAQQYDDTKKVTVNLYGDGAANQGQVHEAYNMAKLWELPVIFGCENNKYGMGTSVERASAMTEYYKRGYYIPGLRINGMDVLAVIAAMKYGKDYVLGGNGPLLYEFQTYRYAGHSVSDPGTAYRSRDEVQAERANDPITTYREKMIEWGVLSEDDVKTMDKEIRSKVDREAQEAEKMAEPPLNSDVLFEDIYVRGSEPAQRRGRTVDETYYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAD9</accession>
    <name>A0A370PAD9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_221430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAD9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="197"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="488" mass="55309" checksum="931EA5EF73D3519B" modified="2018-11-07" version="1">MTSFFSTPPFRRNISLSSCLTSDDNDGVAEPISPNDVATVASAPARPTSPGDRSPSVRFTARRESRRRVASVPSTGHTERPGNLISPKPRTVQQYILESDEANQKSNHLRRLMAGSPSSPPRSREAPRFSGGPVGDAISPGVKDVFQDAVEEQVQSPAEDDKPGVTTEAILSSMHNIIRGSYNENNKGYAYVYRDSKDECQRFKIGSTDRPEVRKKELDKQCKYVDWELVQDPKLPIWEYKRLERLAHSELQNLRCNFICPGDGIKHREYFYGSNATASEVLERWSRWLVEHEPYDEKSKLKPFWSERLEWFTGNKTASFYFNCKKADCSRRDSIPAACQECLRIGWKVWTEPTTLDKVRYYCPCYAKAIWERTPALPTCFLFILCGRLIGPMILAHFHDYGLRGEVIVTDVVICMCAFLCHYSQNKALQKALQRGSGTKRTETIHKELGCQSNTRWQSWQSRFPDPPGCLQGTAGEARPCTVSVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAX5</accession>
    <name>A0A370PAX5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_329228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="34338" checksum="664D93423F5F4677" modified="2018-11-07" version="1">MSKILVVVGATGQQGSSIINSILSDPKLSPEYTIRGTTRDPNSSKAQALAAKGIEIVAANFNEPESLQRAFTGAHTVFANTPTIYDGHTYEHEVAHGRALIDAAVAVGVPFYIYSTLPSISKISQGWLKNGGHFDGKEEVEQYIRTQPIRSAFVAPGSFMSNFHDTMAPRRMENGDYALLLPVPAHIRLPLIETEADLGKWVAAILADFDQYEGEVLCCATALYSFEEIVQTMSRVSGKTVTYREVPVEIWATYLPELMRGYIVDMFTLFRVYGYYGDGTEKVKWSAEQARGDLTTLEEYLRKYPLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBE1</accession>
    <name>A0A370PBE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_256008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="78469" checksum="BC388CE34A3C0F5A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBH7</accession>
    <name>A0A370PBH7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_278061</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="290"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="444" mass="51237" checksum="96222D221262FF91" modified="2018-11-07" version="1">MSDQAILRITREIKQIQQGADLSLAVYYDDSDIRSVRALILGPPDTPYQFGFFEFLIKFGKDYPATSPNVRALTTNGGRSRFNPNIYSSGRVCLSILGTWRGESGEQWSSAQCLESLLISIQSLMSSNPYENEPGYEGTRSSSDKENMEAYVSKIHHETLRLAVLEPLEASLNISLEGDADSLADPTSEGDDNIIYEDGRSSFDPFSDFRKKRFLWYYEPYMQSLVAAEKKHSRKTKFQRMPFEGGNNSMDGHFDYPELRRRMAVVKDAILRETHGWAVEGQLAKKQEWGIAASLQRQYEQIVENLKHQNNITVDLYLDEGNPFMWRLTYFGRPMTQLDGGMFKVLIHLSPRFPEEQPRVFLEASSFFHIRVSKEGVLCYVPRRTEEMRYHIEGIVASLEEEHPPYDPRTTVNPEATKLFWGTPEDRRKYNRELRRSVERTVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW6</accession>
    <name>A0A370PBW6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_296143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="14515" checksum="13826D16534A14F8" modified="2018-11-07" version="1">MAGPTSPSSLSDSTKDQTNLSAFWMDDVLIPKEKIELGRNFATYDPSDTYWKIVCINMALQLAKWKEEKARDYSDVDNAVFENEHYQCLEDFEIPTTVAPTTETLLDVTPENVTRLQAQNEWMDSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC76</accession>
    <name>A0A370PC76_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_238457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="566" mass="61784" checksum="2D46383404EDDC0A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCA8</accession>
    <name>A0A370PCA8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_255239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="33117" checksum="CBD9DCEB7EE3DFD2" modified="2018-11-07" version="1">MPLPKESYLSNTWKDGLFTNKVVFCTGGAGTICSAQVRALVHLGADACIIGRNVEKTEKAAQDIATARPGAKVIGIGAVDVRKLESLQAAADRCVKELGGIDYVIAGAAGNFLASINQLSANAFKSVIDIDVLGSYNTLKATIPYLVESAKKHRVDSETLKPSAAGTGGRIIFVSATLHYRTAPFQTHVSVAKAGVDALSHSVAIEFGPLGVTSNIIAPGPIASTEGLDRLLPSDTKDAYIKSQPLGRVGSVRDISDATVYLFADTGSYVSGQTLVVDGASWRMSATGATYGKLAYPDFLLSGDAVPNVKGQKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCB5</accession>
    <name>A0A370PCB5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_328772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="387" mass="41642" checksum="DD10D04AC368BFC2" modified="2018-11-07" version="1">MTSLSAKRKSPEDASHNDEARTPTNSPPRKKLRITRRQKQALIDNLQLELTERARKLRAQYALQANDLRARIERRVNRIPVALRKATMGELLEKHMASLRAQQANPSPRKLLSPAKASRSFRTVSVSPNVRKASAASPSARRVKKQSHGEIYSDKENAPAAGEQLDVLKNPKRRGPGAAAGTSRVVSQEMRGADYRILSPKTSNSRTYPHSPLRASPEKPTNSSYLARPMSPLKPTSPLKSTSASIPALADNARIRPVKNTSTSIKDNRPPSQAKRPASRAATATSKTTRSPLPRPATRQLERRGSVSSSASSGTTVAKPTRTGAGARKATTASTSSATAKKTTVARSQATSATAKRNTTSATSKRAPTPAGGEAPTAARRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCI9</accession>
    <name>A0A370PCI9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_304320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCI9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="835" mass="91500" checksum="20F34B6E391081E4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCK9</accession>
    <name>A0A370PCK9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_219332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCK9"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017060167" description="endo-1,4-beta-xylanase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="37590" checksum="867FB6D6BD5FDA0F" modified="2018-11-07" version="1">MKTLSPATLITALLAASEGAIAFTKTNTSPLKEVAESKGILIGSGAINPNYLNDSLFATVLADQFQSLAPENELKWTFIHPTPGHYNWNATDRLVSFAEKHNMVVKGHGLISSCCNPDYLLNITDPKLFRAAMATHFDAIMHRYAGKMDRWDVVTEALKTMGGGLQVNDFYKVLGPEYIADAFHIARAAGPDAKLFLSESLVETYPGKRQELYDLVSGLVLDNVPIDGVALQMHVTEVAPIPGVITDIVKSYNALGLEVSISEMDVHTLNTTLETDIYNAVLTEALEAGITDITFWGFTDKHAYTWIKGAKPLMFDEHYNPKGEFYATHTALTSFDNTPRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCM9</accession>
    <name>A0A370PCM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_45967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="82" mass="9681" checksum="F9C2ECEA471B14CC" modified="2018-11-07" version="1">MLLSAEMARNLYDVMDVHSMWHRLCFLGALSCFLSRVSFFFRSVSRVHRLQCLRIALEVGVCNRCMVFVSGWNVIYVKHYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCQ4</accession>
    <name>A0A370PCQ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCQ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="251" mass="27983" checksum="FDBB7923E9640A78" modified="2018-11-07" version="1">MDFIKNHEHQHEQSTNDPREVKEKLCQLVKDSLHTTANGSTEAEKQAHQLGSSPPLDVSPTNSSPNPDNDNKTDKEGDEPRPEAKEATGSNNDPSPSPNDDNKTDKEADEDADETTTPAKEATKPDDQLPQPSEDQSNTPEPDTSEAEGLRLQKREHNRVYEENMHAESCCVIPDEDCFGHLNPKETGEDEDEELQRQKREFHEETYTLIERGCGITLTPSGRELMAKLSSEEELNVNADIGINPIVFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD84</accession>
    <name>A0A370PD84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">M752DRAFT_295979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD84"/>
    <dbReference type="SMR" id="A0A370PD84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="29185" checksum="E6926D49AC735996" modified="2018-11-07" version="1">MAVGKNKRLSKGKKGVKKRTVDPFTRKDEYSVKAPSTFQTRDVGKTLVNRTSGLKNANDSLKGRIFEVSLADLQNDEDHAFRKVKLRVDEIQGKNCLTNFHGLDFTTDKLRSLVRKWQSLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYARSSQIRAIRKKMTEIMQREAASCSLAQLTTKLIPEVIGREIEKATQGIYPLQNVHIRKVKLLKSPKFDLGALLNLHGESTTDDKGHKVEREFKEQVLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDQ1</accession>
    <name>A0A370PDQ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_285124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDQ1"/>
    <dbReference type="SMR" id="A0A370PDQ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="61"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="492" mass="50990" checksum="676A5272FD504328" modified="2018-11-07" version="1">MKGAALIPLAAGIPFAHGLSLHKRDGPAVVRMPIERRSAQSLQKRDSTVGVTLQNWDATYYAVNLTLGTPAQKVSLALDTGSSDLWVNTGNSTYCSIDNLCTPYGLYNASESSTVKTVGTHLNDTYADGTNLYGPYVTDKLTIGNTTIDNMQFGIAESTTSKRGIAGVGYKISTYQAEHDDKVYANLPQALVDSGAIKSAAYSIWLDSLEASTGSLLFGGVNTAKYKGDLQTLPIIPVYGKYYSLAIALTELSVATDSNSSSFTDSLPLSVSLDTGTTMTALPSDLVNKVYDALNATYDKTYDMAYIDCDTREADYNVTYSFSGATITVSMSELIIPATEPGWPDNTCVLGLVPSQPGVNLLGDTFLRSAYVVYDLENNEISLANTNFNPGDDDILEIGTGTSAVPGATPVPSAVSSATGNGLISSGTAVPTLSGVTITATATATGSTGTGSSGGSSAEATSTSSEGAAAQATSNPMNLLPGLAGIGLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ1</accession>
    <name>A0A370PDZ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_328429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016903251" evidence="2">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="398" mass="42312" checksum="30562EB74D8332F6" modified="2018-11-07" version="1">MVRQTAWLLPILLLQALPFAVTRPTAVNVDIQVPDACTDGQDCTMNLHGGKDGDDDDDDDDDNNDITDQVRHKHHHKDQDGDDDDDGDWDSDSDSDSDDDDDDDDDDDDHHHGNGCNTQTITLTTIEPGPTQTITITTDATAGLVPPTDCPTTTTVSITGPAITSTTTATETAIQTATVTETESDIITATATITDTSTITQPPVTTTETATATITDTDTISFTIHDTETITIPGPTITETDVLTATRTITETDTDTVTLPASTITDTSTITLPASTVTATETATATVTITDDTCPTGTPGGDGDTGLDFGQCSDPSISWQYGLDNRTEWSYITNNQVEFEHGSSTTIDTLMNFICNRLISPCNAPQETIDACYSAEDEVNSSGLVGQDAADLWNELMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFK9</accession>
    <name>A0A370PFK9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_236074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016894177" evidence="10">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="57350" checksum="489B06B5C32D4603" modified="2018-11-07" version="1">MEFHPKLIILLLTALVIAGESFRRYLKRRQFARRHGCEPVARSFSKDPFLGLDTILGTMRTRREHRILERSCRLFRTLGNTFTVKELGRSAILTIEPENIKTVLSLNFNDYSLKHRYEAMKPLLGEGIFNTDGHHWATSRALIRPSFAREQVTDLRLLEELIQDLFALLPRDGSTVDLQELFFRYTIDSATEFLFGQSVGALKESHSEVGFAEAFHYAQMAIPMRGMLGPLGVFFRDRKAEECNRICRDFVQRFVDEALYAAATRKEDEATETKRKYIFSHELASRTYDKQRILDELMNVLLAGRDTTASLLGNMFFVLAKNPAIWARLRAEVESLQSRPPTYEELRGLKYVQCCVNESLRLHPVVPRNEREAAKDTILPVGGGKDGLSPVFVPKGAVVGYNVYAMHRRPDIYGPDAEVFRPERWEDGKLQPRWGYLPFNGGPRICIGQRYALTEVSYVLVRMVQEFRSLESRDPGPWVEGLALTLCSRNGAKVGLIPSHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFL4</accession>
    <name>A0A370PFL4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_319799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29183" checksum="16A9226FB9E4323E" modified="2018-11-07" version="1">MGRTLTYPKRPSNTVNRYKHRATYDLGAIHEIINSTQVLHVSFSPGPSEPFPAILPMIGQMGSFDYPSASIDEPLDCYLHGYVSSRIMNLARDAEGEGLPICVAASKVDGLVLSLTPNSHSYNYRSAILQGYAKLVTDEAEKLYAMELITNSVLSDRWAHTRVPPDRAEMSSTVILKVKIMSGSGKIRDGSVSDEKKDTGSEEVTNRVWTGVVPVWETFGEPVPSTGNKVPEVPGYVKSFVAAKNNENRAYAEKAVGIELPPEEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG34</accession>
    <name>A0A370PG34_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_236206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG34"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="249" mass="26118" checksum="437D32490019FA50" modified="2018-11-07" version="1">MSSSDIQGYAIRRNNSCLSDEVGCGKTWDTWHACCPSGSKCPGKEYSIQNNVCCPTWTDCTSEIKPAVCANSTWNMYDYDGYFCCTQDESGFRLKGTDWVGCLSPDSPGNASYSALRLIGTASSTATSAPTSTSASTTTASTAAGTTTAAASSGSGTNTGAIAGGVVGGVVGAAAIAGLLFYFLRRHNKQRPESQTQMHLQPQDPSPQYSAYAYSQQPYSTGASELDGQSVPAELPSTNGPKHELAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG67</accession>
    <name>A0A370PG67_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_236246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG67"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47479" checksum="2E4A6B657CE008ED" modified="2018-11-07" version="1">MSSPLTNDPARVARIMLSWHSLDLVSCTTLQTLWAGYGHICALTARATTAEAAEHLGKLCGVDSRTAGSTFPLILKLISPPRKAAGKEDEGHLRKMLSYEVEQYFYSDVVPRLGDDIAVANCLASTRDMRGKQCEEELRGMMATIMVDLRPAFPVAGEKRSVLSRAQVYGALNWLARFHSRSWGLLSDDRSLDGYVLPPLEEAKRRRDLGKTEVGDALWLNGGYTYLATRRKEYASLVEDTDSEWSDILCTASDESALSVAEMAAFLLTPCGRKMESLIHGDVKSENLFTTSKGDEVAFFDFQYVGLGLGVCDLAKLFTCSVPLRMLADDEEDLLPEQLEMCEGERTLLEHYHKTLLQDKGERWYEWESFVRHWETALVDWCRFQASWGFWGNTEWLEARVRSIVSDLGWREWLSRSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH5</accession>
    <name>A0A370PGH5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_217367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="512"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="621" mass="68342" checksum="C0ABA4339B841109" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGL3</accession>
    <name>A0A370PGL3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_301711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGL3"/>
    <dbReference type="SMR" id="A0A370PGL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="516" mass="56459" checksum="E325304BA302A22D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH71</accession>
    <name>A0A370PH71_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_327634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="36599" checksum="3589BA1340804BB4" modified="2018-11-07" version="1">MPSSLVFITGATGFIGSAVAIKTLQAGYSLRISVRKEEQIPKLKAALSEFKDKIDFVITPDITQQSSFSGKLDGASYVLHIASPMPHGTNPETYFGPAIKGTTAILKEAAKVSSIKKVVITSSIAALTPRSGLPKGGVIKEDNDWDLSVDQTADFTGADDEATGMSLYHASKLLANQASWDFKKTENPSFSLVTIHPAFVYGRNPLQSTAEELSGTNALFFLTVADGKPLVPITAVHIDDVAEGHVKALADNIPDGSSYLLAGKKAFWRDVGAIVKKEYPHLGFKISEEIAGESWPVNTTKAETELGMHWRSLEQMTRDVIDQQIELRSQAKILENVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH88</accession>
    <name>A0A370PH88_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_336695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH88"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF32">
        <property type="entry name" value="FAD-LINKED OXIDOREDUCTASE AFOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017077064" evidence="6">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="489" mass="52762" checksum="20AAADD5071A999E" modified="2018-11-07" version="1">MFRTILLCSLGLSTLSSAATHNITSIFSSSLSPGAQIFLPSDTNYTEDVTQRWTTYDAPTYIGAIKPATVKDIQNIVTLAASNKIPFLATAGGHGATITYVNCTNGIEIDISNFNTVLIDASNNTMTVGGAVRFEDIIPPLYEAGKELPTGTAPCVGLVGATIGGGIGNLQGLHGLILDSLLSVELVTPSGDVLMVSTSENADLFWAIRGAGANFGIITSATYKIYSATNNGLAMSANYLFPASENRSVWEIFQSFDETLPPELSLTAYSGFNQTTQEMELIVNAIYYGPKEEGVSYLTNLTALNATETNLMMVAWPNVTSSMAFGADGDACTTGSYLNTWGLGLAETNIDTYTTFFNELQAFSQAHPDYSGIFVVDRYSSAAAAAVPANSTSYGYGYRNINSHLLFENSYPSDNSTLDNAVNAFMRSIRSQFQRTSGFSEMEIYLNYAHGDEGADVWYSPQHLPKLSQLKSKWDPDELFSFNYPVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHL9</accession>
    <name>A0A370PHL9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_235963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHL9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="65294" checksum="DF126E3E3CCD367D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI89</accession>
    <name>A0A370PI89_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_21600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI89"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="626" mass="70194" checksum="6FF085248889A78F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIE5</accession>
    <name>A0A370PIE5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_252299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="722" mass="80635" checksum="DDCC02018DF77820" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIN6</accession>
    <name>A0A370PIN6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_276735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="197" mass="22188" checksum="4C966F44049EACBF" modified="2018-11-07" version="1">MDHVSRAIQQPRAVVTRLQRYCFRRNYHLRSSSSRVIPPSSHRLGQPRVAATFNTFTSNLPKIAPLYRIALRHASTMADPQFAEGTNPEQARQGLQSLQEQGWVLDEDGQGVKKTYYFKSYFKAVSFVNVVASQSSTKKHHPTMTVRIGSVDIHWTTHHPRGLSEKDLEMAQHCDEAAELMGSVEQGQGKKCAPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ39</accession>
    <name>A0A370PJ39_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_276603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="44299" checksum="ECAA4EAA15D53FBC" modified="2018-11-07" version="1">MSSAQQRLTSIANQLSGPGAASAKQRVLFKNPDDIVITLAVRTPLTKARKGGLKDTSLDDLLISLLTSIREKSNLDPNLVEDVCVGNVLCPGAAYVARSAVLAAGFPVTAAASVANRFCSSGLLAVQNIANQIMAGSIDVGIAVGAESMSTNADGGSPEMSSKILNHPIASQNIQPMGQTSENVASQFNITREMHDRFAANSYQKAEHAQKAGWFNDEIVPVKTIIKDPKTGETKEVVVDRDDGIRYGTTAESLGKIRSAFPQWKPSATTGGNASQITDGAAGLILMKRSRAQELGQPIVAKFCGATVAGLEPRIMGIGPSIAIPKILSKFGLSKEDIDIFEINEAFASMGTYCVQKLGLDEAKVNPRGGAIAFGHPLGCTGARQVVTALSELRRQNKRIAVTSMCVGTGMGMAGIFVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJA4</accession>
    <name>A0A370PJA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_300465</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="58876" checksum="0DC5F134C3A55523" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJH9</accession>
    <name>A0A370PJH9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_266122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="26796" checksum="E42811AD92809ACF" modified="2018-11-07" version="1">MDGKGIAHPVCVNHDEDAERLSTILSPDSFRICTATLARRVSGSTRALVNVGSVEHTPTGPHGCLSNKPECKPMKSEDESLPIETTILSDGSGFPIPAAGWNTTVPAHGQDQAAFAKTAQFQAHQLAPPSSHAASQYKHNFPYAGVMDGSICRSQHPRENPPVSDLTMLQDPEPSYMRRSYREEIEAANGGIRPDDLLRTYIPMNLKCILRACDRVFDDEDEAEDHFQLDHNYPENCEWGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV1</accession>
    <name>A0A370PJV1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_266279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35241" checksum="2FB0B0D7691C8017" modified="2018-11-07" version="1">MVFSLTNVNIFAPQEEYDDEGENTTEKAGLLRSESYQPPFENPRRRLNYCASVLLFSNICLATLLFVAVHLLQKQYSLLTGPDPPYSPLREDGVIKYINMKYEPDPEFQSPIVPGKEDPWTSWALALENDNGFKIANETAKKHGLPKSVELYRDPGYLIYGLGVYHQLHCLNRLRKSFYPDIFYPNMSTEQIEIHKSSYKHAANTISYTTNSYSDHCFDAIRQAILCHGDISLIYWWDPNYTYIDDDGIERYTEDYLKKSPRERQVGLHASWSSEVQCRDMDAINSWVKERMVDPDKYGGREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJY3</accession>
    <name>A0A370PJY3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_251642</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.20:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="561"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="1261"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger FPG/IleRS-type" evidence="14">
        <location>
            <begin position="1489"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1524" mass="169526" checksum="BEEBF8D7C38491B2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK49</accession>
    <name>A0A370PK49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_293658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620964" evidence="6">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="30224" checksum="FC93192BA2B66B3D" modified="2018-11-07" version="1">MSLLPTGAKLWLLNLGILDVDAANVLIGANQFPAHLPPQPHERRDLVMIAALIFHPEIGLVLFDTGACEDVIGSWGTKAMECAPRIWNKSVHGLPEAIKATGAGQIGDVKAVVLSHLHCDHAGGLEHFFGTDIPIWCHEEEFKNAFWTFATGIERGTYLSDYLNVTRLNWKTFSGQTFELFQGITMHHCAGHTAGSVAMELGLEQTGTVVLTGDMFHVWENYKQGLPPGTLTRDFNAWHRSREYIRNLVARKKAKVVLGHELGYFNAFGPGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLJ2</accession>
    <name>A0A370PLJ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="588"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="762" mass="82969" checksum="5ED632C2F13A9D3D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM88</accession>
    <name>A0A370PM88_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-beta-1,3-glucanase Exg0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_155609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM88"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016967906" evidence="5">
        <location>
            <begin position="29"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="71"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="580"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="949" mass="99694" checksum="256C46EF928D6296" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMT6</accession>
    <name>A0A370PMT6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_335299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMT6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="213"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="42305" checksum="04B50A49EB9756B4" modified="2018-11-07" version="1">MDFASLMSKEISKAKPKADSQDSSKPKYTRRGDLEAARIAAYNEEQERLAREREERNAQKRKLEDEEADRRREREEKKRRLAEESRKKREEEEAARERERRKRLGLPELPPTESGDDKEGEGKEGGEEDIPEEELLKKLREMEEPAILFGETHKGRLRRYRRLLQRSLTPQPQLSDGPIPTTLELVPEVDMKIPETAPKDLEGKKFLFRQLASYFNMVLREWELALAKRDASVKLSLQGKQAYNAMVQSRENMKPLFRKFEKVDIDDGVLDHVVEIVSKAQQRRYVDANDAYLRLSIGKAAWPIGVTMVGIHERSAREKLHQSDQQAHILSDEITRKYLQSIKRCLSFAQTRWPPDDQLQIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNQ9</accession>
    <name>A0A370PNQ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_325738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="386" mass="42852" checksum="923517D873378DCA" modified="2018-11-07" version="1">MWVLDLKMDPNALYIALFIRDDPPKPNDYHWALYHHRIDSGTEYHITNEGNGWMAGHGPESGTGILKAFLLVGLILFATMKSTTSAQETLERVFRSYDGNLNDNEYRTCRTWLLDVLRDLQEEMGMLNGVDIESLEKEAMDWGNQYGFEASQNIVDPQSATLTNIEVLAYLTANPPRRPPNPPPNSRNWVPSPDLRDHNTVVKEIHNYVTRLSPHLLKYPKYTHLSPAQIQAQSQSTTTTAIPPSQINAPTPLDHALRELVTRLQPYGLTKGEVLMIVNLGVGLHAPATEGEEGEEMGEGGEEDENAEHHGNGGEETNGMMEVDGAEDGQGGDGEIPEEDYGALALLDTVIEEREERLSNEDVTNVLAIIRETLGSRKGEGMDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNZ1</accession>
    <name>A0A370PNZ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_249287</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000009">
        <property type="entry name" value="Vesicular-fusion protein sec18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="16">
        <location>
            <begin position="76"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="184"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="324"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="606"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="817" mass="89117" checksum="F255816BC64BB28B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP33</accession>
    <name>A0A370PP33_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_232235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with MCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000286">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63400" checksum="F330E108466C691B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP34</accession>
    <name>A0A370PP34_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_147587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP34"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="37339" checksum="AE3313958D60258F" modified="2018-11-07" version="1">MASPAQAITLEEHAIFPSLESNNFFYDNTWKIYPECRNLAKDHSKARLANMDAGNVSYQILSHLPGGIASTDPARCHAANNEMAAAIKQHPDRFGGFAALPMAYPLEAAQELRRTVTDLGFLGALIDNHLPDGTTHYDDKRFWPVFAAAESLDVPLYIHPSTPSPESIQSRFSGNYPLPAELGLASAAWGWHENVGLHILKLYAAGVFEQYPKLKIVIGHMGELLPIMLHRVARLGFFKELAASRRKGIMDVWNENIWVTTSGVFSIETLMMLLQVTKVERVMYSVDYPFEDNVTGKEFLKKVRESGRLSAEEVDLIEFGNAREFLKLGSRAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPF8</accession>
    <name>A0A370PPF8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="250" mass="28477" checksum="71491E2469223324" modified="2018-11-07" version="1">MSRPDITLYTAQTPNGIKISIALEELGLPYKVEKIDITKNTQKEPWFLEINPNGRIPALTDTFTDGSKIRLFESGSILTYLAEQYDKDHKISYPQGTREYYEQNSWLYFQNAGVGPMQGQANHFHRYAPERIEYGVNRYINETRRLYSVLDAHLAKSKSGYLVGDHVSIADISHWGWVAAAGWAGVDIEEFPNLKAWEERMAAREGVEKGRHVPSPHTIKELLKDKAKAEKIAEESKGWIQQGMKADAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPZ2</accession>
    <name>A0A370PPZ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_274623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPZ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="29431" checksum="2F1F5C9A74A8D268" modified="2018-11-07" version="1">MLRNSRLASRFARTGVLQARASPRTSSLQQQHPSSLLSSPSSPPPTTTINTFRLASTTTTTPPNDTQTTPDITNHYTIFKQTLPAGPPPSSPFSIPTADLRREFLRWQSLIHPDKYPQGPQKQQAEALSARINEAYRTLLDPLQRAQYLLREMHGIDVTAEDGASKHALDAETLMEVMEVQETIEEVTDSGEDAAAAEEKINELKVENQGRVEECVRVLGEAFDKGDIELARRECVRLRFWYSVGEGLREWEPGNREIRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR26</accession>
    <name>A0A370PR26_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_291768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="68"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="208" mass="22988" checksum="CB68193EC8503F37" modified="2018-11-07" version="1">MAQARLSLPRNFHRVSLACYYPPSSRPTVATRTFASRRAAAISTPSGLDSDHHLSAAREWAARLNSKAITIPRDICEISFSRSSGPGGQNVNKVNSKATLRVPLKSLLPFVPQLLHAPLQASRYVAAKSQILVIQSDESRRQTANVEACYDKLHQVLKSIAEDTIPGETSQEQRDKVQKLKKAANEARIKSKKLHSSKKSSRRGSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRA7</accession>
    <name>A0A370PRA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_290784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="35220" checksum="2D6416D75DF808E7" modified="2018-11-07" version="1">MPPLNPTSQKAIARLRNYTPPPTTYTSVPLSRRAAVLVLLYADQKGDLRVVLTMRAATLRSYAGQAALPGGRADSLSETPIQTARREAKEEIGLPEHDEHLPRPFTVEHLCEFPANLARTEQVVRPCVALLHSFDERTGENADPEVSLIPRLDPREVAAVFTAPFRNFLSCRDMEDWGDGDPTDWYKGAWTEWHQEDWRMHQFFVPVRPKEVVKPKTRTEEQKEAVSRLEEQEKASQVTRYRVFGMTARMLVDVARVAYAEEPEFEHNSHFGDEAIIEKLRKMGRLSPIRRTGDQLTRRDMEMAAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS03</accession>
    <name>A0A370PS03_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_247640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="36283" checksum="09B3E3E2C1376DED" modified="2018-11-07" version="1">MGSIMKAIDIQGGKGSADALFVDQIPIPKPSPGQALVKIKAFGLNRMDLLQREGKYPVPPQAPSTMGVEFSGVIKELGANTNNGFQIGDSVFGLAYGGAYAEYIVVSTKMLIHKPSGLTWEEAAGIPETWITASQALYLIGEFSAGKSVLWHAGASSVSIAGIQLAKIGKASAVYVTAGSQEKIDFCVHELGATAGYNYKTQDWASEILKETNGRGVDIVVDFVGATHFQGNLDVAARDARIVQLGQMSGSILPANTDISGILRKRLRFEGSTLRSRDEDYQGRLRDLLVDHALPKFKDQTFKVFIDKVFAFEEIADAHRLLESNQTKGKIICTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS29</accession>
    <name>A0A370PS29_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_291077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="170" mass="18656" checksum="3632506A57B04709" modified="2018-11-07" version="1">MASRFPRSNLHQRDPRASSSLFDSYGGGSRPASKSPGSVGGYGYGGYTPPAGDSSVNGNTRGGFRSATPNAKGHYSDAVLSHLESQNDAEVEGISAKVKMLKDLTVAIGDEIRDTSTISDLNNTFENTRVRLRGNMNRMLRMAERTGVSWKVWLAFFFAVFLLFFYVWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS73</accession>
    <name>A0A370PS73_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_274090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="37793" checksum="A3BFB447C31BED87" modified="2018-11-07" version="1">MSASSLVDLDSLEATILIDNDLDPMSPVPPDTVEVTGLMRTLATSSPHDIHDRGDAHKELQMEDICCSAHGLSILVTATKDNKQHTILFDAGPEGDAWERNVKRLRPDLASVEVVQLSHWHRDHSGGLQRAIEMITDAKKKAGRNSSATVVDLHPDRPDYRGMAIGHNIISLQADPTFEELEAAGGVVQKHADAHTVLDDFFFISGEIPRRTGYEHGLKGGMRFDAEEKDWFSDEGIADERFLMCRLKDKGIVMFTACSHAGVVNCAQHAVDSLDGEVPLHAIVGGFHLATSETSQMESTVRDLKRLDPAVILPGHCSGWRAKFAIERSMPGAMVPCSVGMRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSE4</accession>
    <name>A0A370PSE4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sex determining protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="524"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63125" checksum="B8A0FC3849C80228" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT30</accession>
    <name>A0A370PT30_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_290215</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT30"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="402"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
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    </evidence>
    <sequence length="622" mass="70617" checksum="C5B60470DCF23F47" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Theobald S."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="126"/>
        </location>
    </feature>
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            <end position="123"/>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45479.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="656" mass="73368" checksum="ADE4402BD3213E73" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
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            <taxon>Aspergillus</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="212"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="RDK45540.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="647" mass="73999" checksum="35A8AA3C0065F980" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUG8</accession>
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    </protein>
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            <taxon>Aspergillus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Strasser K."/>
                <person name="McDonnell E."/>
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                <person name="Clum A."/>
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                <person name="Mortensen U.H."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41404" checksum="D69DCF3DB634D124" modified="2018-11-07" version="1">MTHLKTETGSPPPLPPRPPLQPNPSKTTTSIILPKPIVIPQTSTTIHGPSYRPFHLAHSPTLSPLLPTPTFLTFLNHLNHVWLANPYLQALSATSNILGFIPSLEAQLAALGMQVAAELGTITVSKLRTRMFLREANERVFGPVGLRVRVLGTEGLLRVLGVEGDRLGLGEVFDYDCEQGGKGGDGGGFDPVRRRMDALREYVAPLVFVDDMDVRTGGGGDWVRKVAEKQEERFTQRQNRVLVRRHRRAVRGIGEAEVVEKELLVKMEEVEAEMMAVKGRAVERLSGPLGESLQGRGIVQDDLDKGLKQLQRKMEKLGREREKRVTKRLQQSKRTFQRVGKREAKIAQNVMWVVVTADDGVEYSTSLSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUQ2</accession>
    <name>A0A370PUQ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_312216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUQ2"/>
    <dbReference type="SMR" id="A0A370PUQ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="354" mass="38898" checksum="BD4E417A09C47179" modified="2018-11-07" version="1">MAHSSTNTAIPKGSWILVTGVNGYVASHTASQLLRQGYRVRGTVRNPSKSQWVEDLFHEKYGADHFELVRVEDITVPGAFDDAVKATGVSGVAHVATILSHTPDLITGVISTNRNLLVSAAREDTIKRFVYTSSSEAATFSSFLEHPAGPSMPIFVDTWNEEAIRRSQTTTMGPKGGFDMYAASKTLGEQEIWKWAKENRPGFVINTVLPSVCFGASIDAKSQGHASSSGWPAAIFRNQFDQVWPFLKHVIPTGAYCVDAEDVALLHVAGLTLPGVKNERLFAFGNPFTWNEVITIFRKAFPDREFPNELPGADKRIRYDIGPDARAQEILRVMGKPGWSTLEDTLIANVSDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUR2</accession>
    <name>A0A370PUR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_247148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000201">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="598"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1185" mass="129409" checksum="F73B0043718477BD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUT0</accession>
    <name>A0A370PUT0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_282019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="333" mass="36561" checksum="ADE43D0CEB11C5BB" modified="2018-11-07" version="1">MTADTAKKVITVVGATGTQGSSVARSLLENPSFEVRCVTRDIFSAKAQALKQLGAVLVKADGFDVTQMTQAFNGSWGAFINTNSEDPLLAELGKTDVDLGGNILRSAAAAGVRHVVYSSAPKPAKLTNGDIRIPGLDWKAEVEAIGHELPFQTFTPIILAWFLENFLSGPYSEIFGGFPIMEDEEGYLTYRIPLWGGREDAPWISVTDDLGDIVHGIFLDPLRWNGRLVQANGDISSFSEIVSKFVKVTGRKARFIPYATPGDFPTHGLQFLQMVRDTFKWTQLRGGEYYGTQITELRSAAELKQASFHAKGGKGRETLLSVEEWFKAHFANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUT9</accession>
    <name>A0A370PUT9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_282014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="32237" checksum="72990567D9C267E6" modified="2018-11-07" version="1">MSHDVINNTRTLVAFGATGQQGGSLVYYVRKDHSSLYHIQAVTRDPSKQSAQNLKFNNVEALQADGHDTASLRRVMHGAYMAFAMTLPKFDSEDARVREIAQGRAIADAAFEKGISCGKYQRVDHFDAKAEVELYMYDLPIRSIFYSPGWFMQNFNRHLAPRQNADGTWSIVNIVTPQTSLPLINQFEEMGKFLAPVLVGPKKFAGQTLSSAERFYSYQGIVQSMSNVWGECGAVFGERLVEMMLYFEEYGYYGPQGKQEVDRMAKIATGDLTTFDEYLARNPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUU1</accession>
    <name>A0A370PUU1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_263544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="524"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112944" checksum="7F6058C5541D8F91" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUY1</accession>
    <name>A0A370PUY1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_228639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUY1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="55319" checksum="678DE59723E6C738" modified="2018-11-07" version="1">MGDNTPIDIIHSRDYDETPNLDPSSQVQEQHQQGSAPKGAETKYEQNIVPDGGYGWVCVACVFWINAHTWGINSSYGVFLSYYLSHNVFANGSALAYAFTGGLSISCALLVAPLATYLIHICGTRLVLNLGVFFETLSLIGSSFATELWHIFLSQGVCFGWGMGFLFVGSVGITPQWFHRRRSLAMGINAAGSGIGGLIYSLAVGAMIPRLGLSWAFRILGIIACVVNLVCANLLKDRNKDIGSRHHAFSLPLLKRPEFLLFLGWGILSMLGYVAVLFSVANFALSVGLSSHQGSVVSALLNLGQGVGRPIVGMFSDKLGRINIATFLTFLCGLFCLVIWIFARSMGVVCFFAVLVGTVAGTYWATVTPVLAEIIGLRDLPSGLSITWLVLVPPTTVSEAIALVLRDNRSTDSVYLRVQIFTGFMYIGGAACLWLVRGWKIGELVQSEKKEGASPGVMVPSSIEKKDEEEPAQKGEEYDPSPGIPTSGVKETQLWSPIHLLRRMVALRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV38</accession>
    <name>A0A370PV38_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_332694</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="29"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="952"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2427"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="952"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2527" mass="276637" checksum="BA345A45A10EC7DB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV43</accession>
    <name>A0A370PV43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_317217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="781" mass="87469" checksum="D75372CF40F8EE82" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV46</accession>
    <name>A0A370PV46_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_317221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV46"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="66"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36785" checksum="CE09D278A002E23D" modified="2018-11-07" version="1">MGSSDPKPKVLLLGDIVHAHTTWSSLSDIADLIRPTATNRAEFIQECQSGALDGVIAAYRTFDSVRITGLIDEELVNALPKSLVYLAHCGAGYDQIDPHACSARTPTPIRISNVPTAVDDATADVNMFLIIGALRNFNAGMHALRVGKWRGQPAPRLGHDPQGKVLGILGMGGIGRNLKKKAEAFGMKVIYHNRRKLSEELADGARYVSFDELLAESDVVSLNLPLNKHTRHIISTAEFAKMKDGVVVVNTARGAVMDEEALVQALDSGKVYSAGLDVFEEEPTVHPGLVRNPNVLLVPHMGTWTVETQTGMEEWAIENVRMALETGKLKSPIPEQADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV48</accession>
    <name>A0A370PV48_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_96790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="32945" checksum="8F0605E369EEB2EC" modified="2018-11-07" version="1">MSQLEVPQAAVPRNATALREVTVTTPLDEVFDAWHEDGAIIIKGILSTEQVNQLESELDPLLNKVPEGSRSSDYRMQAFHGRKTKRAGDITNNSKVFRDYLLDNDFLHAVCKRTFSEGGQAGDYWLGTAATIHVGPHQEPQTLHRDLGSYPPYKKLGPEGTEAQINFLIATTDFTEANGATRVIPGSNKWAFSERGSPEQTIPAEMQAGDCLLISGKVVHGTGRNTTDRVRGCLAMTVCASFLTPEEAHPFIVSMETARGLSRRAQQFLGFRSQWPRGSPGLWTKDYSELALHLKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVG1</accession>
    <name>A0A370PVG1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_98151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVG1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53239" checksum="D47A102E8289C49D" modified="2018-11-07" version="1">MNREIPGFYYDPEKKKYFKIQANHKATPGSQYTQDSVKRKRVDQEKRQRKIHLTKRATKEKIKRAAFLSNPLLGVQREIGSEVVSSSIRQEQRSLIYASQLRRNQLHQFEPWPDEYTIKHVLRNKRSGILIASGHRGGESSVSVCFPDCDQDKWTYNRTMERVLFKEPYRLSSVSLSHTGYLLATMDSGPNGDSFLAPRMLPDPDEGGDYRWPTSFYHPIRLRTSSSLWCSSACPTGEMPLFAVGTSDGLYTLEGFGSYWALSKKSFPNDILTGKPILHRRVDSSHAIVSSVEWLSSDVIAAGLKDSAIFLHDLRSGGSATRLQHPHAVTKMRRVDPYRIVVAGINSLQMYDIRYPANGLQRNPQPNKKHHTSTKPYLTFADYSPEGIPDFDISLELGLLASASDERKIQLFSLRTGAQVPSPLSGYQYANPISSVCFEPGDGSLHGPQTPSLLVCAQATVDEWIWSNTPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW79</accession>
    <name>A0A370PW79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_102766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="38046" checksum="21659DEE72F70BE2" modified="2018-11-07" version="1">MSTQQDPNPSNEGKHDGLSKYVKRMKMALRRSSTVRTTTPVMQKSREPEPSQAPAPQRIPQAPTVKATPDATVFTNWGAIQEEKARALFAKYGLTLEPGEWRSPSDTTVQRVVRPIRMRVRRTCHRCQTTFGPNKVCVNCQHVRCKSCPHHPSTKTNDHRDDTQAALQAIVAQKLHKPVPVQHKPKQPPLTLPSRTGGQDVIHHPTRQRVRRTCHQCSTVFAPDATECSTCQHIRCTMCPRDPPKLGKYPHGYPGDVDAPAEPPARTWKKPRQRVRYTCHKCTTLYRSGERNCSNCGQEKGPETIRDPPRRDKPKPDPEIVRRVEERLAKVRISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWE1</accession>
    <name>A0A370PWE1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="41147" checksum="AF645BC5E6288C63" modified="2018-11-07" version="1">MAGAVRQPIDVPSLERYLNLNVPDIKTPLDVKQFGFGQSNPTYQLTTADGSKYVLRKKPPGKLLSKTAHKVEREYKIIHALGNTDVPVPKAYCLCEDSSVIGTPFYIMEFLDGRHFTDPAMPGVDPAERTALWQDAVRTLAKFHRVVPQKVGLDRFGKPTGYYDRQIATFTAVAQAQAQAVDVETKEPVGELPHFMDMVRFFDDKTTQPQDRGTLVHGDYKIDNMIFHKSEPRVIGLLDWEMATVGHPLSDFCNLTSPFFLDGVDHKKEMFVPKVVPGLPAREDCIRWYREVSGYDPTGDIPWGDAFFSWRSSVIMHGIKARYALRQASSARAAEYARNTEPFALEAWERVKRVRAQLGQKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX54</accession>
    <name>A0A370PX54_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_316870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX54"/>
    <dbReference type="SMR" id="A0A370PX54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="35038" checksum="CF1DF23A3384B39C" modified="2018-11-07" version="1">MSAKTVQGRNGKKPASPAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRARAPGVKPRGFVATGVEIVKKETAMGLYKGLGAVLGGIIPKMAIRFTSYESYKQMLADKETGAVTSKATFLAGLAAGVTEAVAVVNPMEVVKIRLQAQHHSLADPLDTPKYRSAPHALFTVIKEEGFSTLYRGVSLTALRQGTNQAANFTAYTELKAFLQRVQPEYSNTQLPSYQTTFIGLISGAVGPFSNAPIDTIKTRLQKTRAEPGQSAVSRIMVIAKDMFKQEGARAFYKGITPRVMRVAPGQAVTFTVYEFLKGKLENSGWAFVGGNYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX75</accession>
    <name>A0A370PX75_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_227693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="12">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="11">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="526" mass="59654" checksum="4DF20DB98B52455A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL0</accession>
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        </recommendedName>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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            <begin position="53"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="RDK46923.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44913" checksum="2BD18B2B1D317CE3" modified="2018-11-07" version="1">MPPTTTSTTSNPTPITNPRRLLILTPTTHSQSIVPPLLHSLTGTPVTTPPTAPGSSSPTPTPTLSSATTLAASSTTSIASSTTITTFAGYTTHPPLHLSNKYYTADVPIWVDEIPLPTPDSSEPTPSVSGSTISPAQWKSEFSSPEAQVVRDAIGAVMICFRNPVQMDPVPGQEQQDVEDRADVRGLKEFVKAVGEVRALIEEERGGVGEVPGLVVLVGEKKTGSGKVGSGDGEEDEDGLGLEIDEVFSEGWWEDQICEMELMGMEVVRWDGKEGEEEEGRNRYGELQGMRRIKEVLETHDWAATEDAETGLLHDGVDDDLERELLGLDDADNGFDLEVDELQREMVGLRMAIERGGGDGFDDDDEGDEELRVDAVEALLLRMRAIKDISDELPEAERKRFAAKAVRDIMREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        </lineage>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 13157</strain>
        </source>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN BNI1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="613"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46999.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="852" mass="94705" checksum="ECE9A6348B8EBA20" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY08</accession>
    <name>A0A370PY08_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
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                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF84">
        <property type="entry name" value="ENZYME FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="43343" checksum="422759172CFC42D5" modified="2018-11-07" version="1">MAPSNLHHPSTRALHADDHLNRVTDVAPPIHLSTTFRFPDNPDDLIPSVDPVEEFDGKNYIYSREFAPNATRFEAVVSSLLNGRAISYSTGLAALQAALVLLNPRRISVGEGYHGSHEVISVVSRLSGLQKLPLDCPADALDKGDVILLETPVNPLGTSFSIDEFAKKAHSRGAYLVVDSTFGPPGLQDPFRWGADLVLHSGSKYFGGHSDLLCGVLATQRKDWEKQLLEDRVALGNVIGNLEAWLGLRSLRTLEVRVQRASQGCGSLVSWLHKALSTPSTAAGSDEQIVQSVVKKIYHTSLQEEPWIQEQMPNGFGPVFSIVLQSEKYAQRLPSKLAFFQHATSLGGVESLIEWRALSDSRVDRKLLRLSIGLENWVDLKNDLLEGFKALLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY12</accession>
    <name>A0A370PY12_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_208229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="561" mass="62723" checksum="718A18372F68F80E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY82</accession>
    <name>A0A370PY82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_70556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52305" checksum="2A4FCB4D31DD4B98" modified="2018-11-07" version="1">MDFRPLQGQEKLQRVTKLLDSLRTDLEAKSLTSKERVQTLLELRQHGTNPNHAHPIYSKEGIELLARYGVDGDSPDVRRAALRCVANALLLDGSMRQLFVDTGYGGKLAERLKCDSSEDEMVISRILFLSTYDTTMDFDNLIRHHSLGENVNYQIVRHAKQFPKSGKKSLSQMDELALTDTLKLIFNVSKIYSDLAAKFSASIPHLFKMINRIDIPPKPLEGLLSYLLNCLSTLDLENKKGKVFDSSPLFPTFNQNCNVDKLINILDQAVSAYGPDELETKAIPLFHTLVVIHEMAPDGPRKYMQWLLLPEDNDRSRPIGQSDTLSSKLLNLSTTPYPNLKTAISELMFVLSGKDAENLTKNIGYGFAAGLLASRGMEIPKTAGEAFATNPNGFDPEINPITGQKWAAEKKDEGPPMTKEEKEREAERLFVLFERAKANGILQVENPVTRALHEGRFEELPDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYC7</accession>
    <name>A0A370PYC7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_323607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058685" evidence="1">
        <location>
            <begin position="17"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="40898" checksum="764FF2ED95037C4F" modified="2018-11-07" version="1">MVRISLFGTPLSPILALGLATCAVAVVDKWTPEGFNWSALDPGSRENWKGLYLNHNGTAEHIHELAVTTGADVRTTEDVTLVVAPWAIGLAWHAFNLVLTGAGLASTINTCAQNEGQADNIFYCITGLLSTIVGVGGEVSAAKKFAQSKGYLGVAANAWLQSGLEQIDLQTFARDLDSLPATNLTSQKAHNHFVHSALRSLSTDEVDFVGYAPDSHKLARRDSSVHPFAPMFRFNHHKYGPMELTSRDTGEGGVHFTISYAGHPTHHATQEKRDEFYKHERLNEHLMEGRFDSEASSADPGDITFNGADAFGQIESQVECFAGTEWNEGNVLSVQMYDQANHATFGFASIGIFPDNSVDSGLQGFEPQGMPLTGGQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYP6</accession>
    <name>A0A370PYP6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor cox23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_273039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="87" mass="10150" checksum="477A14C8C491DC09" modified="2018-11-07" version="1">MASQSDKQPSSSDQTNPNAWERVERKFTSKTASEYFDPCQDFADRSLKCMKRNGFDKEMCSDYFQAYRDCKKEWLTQKKLGSSAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYR5</accession>
    <name>A0A370PYR5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_68959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYR5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12437" checksum="CD06213CF9832D09" modified="2018-11-07" version="1">MAPPTDCLLLELAFSNFSFPPNLRISPSTQTQTQTQTQDFNKRSRVNCHRIRDESSKPESIVTQPSSRPQPFSRGSVPIDGLQWTLFRLGSDTGSNESNHLPYPSETIQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYW3</accession>
    <name>A0A370PYW3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_228592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYW3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="594" mass="63157" checksum="F7793515156710B2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD5</accession>
    <name>A0A370PZD5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_260920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZD5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="40566" checksum="D3574C298EC0BF19" modified="2018-11-07" version="1">MPSRWFAQSEVAPGTIIQLRKARTICGTNMTPPWPVLVSFATHMDRDGPVQGHMRYYKQIPIEGTEAEPPTTRAEQAKFFCPIELKHLRTLTQKGSTITPRVLDSKEDKQDNTGFVPGGFVTWVVWEVVPGLQLGNDVGSAPFWGLGRDERDAVRQAFQESICKLEIWGHLPYPEHAKNLVWDSTTGSLYYVGFLLTCKGDPRAVWSPAKWADWTGGDIIDGVHMTISGSFYTVHLFDIFAVYYFLQVGATPMRARLASSSASIMMGVPLAYCRGIPRFFSRRRVLMQQRISQSKAFTAIVTLGMVALSDLGSEQCLDAKRCVADSIALRGHSQHYLGFLTQTVRILDGFLSHTQTRNANSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZT3</accession>
    <name>A0A370PZT3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_331482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZT3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="564" mass="61533" checksum="4C2CC4239C512CAB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZT8</accession>
    <name>A0A370PZT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis acuK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_4118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZT8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="58895" checksum="2B1BE9DB4A62B862" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0H1</accession>
    <name>A0A370Q0H1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_288405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0H1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="346" mass="38148" checksum="4827AC3B70D7085C" modified="2018-11-07" version="1">MTNNPSYWIESEDWHTAGEPFRIIPRVPSGFMPAGRTVSDRRTEIIQTENHPLDRLRKFLSHEPRGHADMYGGFITPPDDMGAHFGVLFWHTSGFSTACGHGTIALGYWAVSKGLVEAPENGAVEVVVDVPSGRVSASVTVRHGKPVHADFINISSYQIARGLSVRIPSRDEEIRVDLAFAGAVMASVNAAELGLEVKPSNADTFIKLQREIKAALGDRASYLDYELYAVIFFEEERNHPDYQKLIVQRSATVYGDGQIDRSPCGSGTCARIATLFGDGQLRKNLKLLHHSIIGSAFEAQIESLRTCPVPGFDSCVVRVRGQAHLVAQSRFFINEEDPLSPGFILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0L7</accession>
    <name>A0A370Q0L7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_8266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0L7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="331" mass="36560" checksum="5435AE90A31E3C3A" modified="2018-11-07" version="1">MGFGDFDSLCEKAPLPLCSLVGPPSSISGSTGIIPNCYARNIELANTIIFEGASCFLHIIALGMTVIMILHIRSKFTAVGRKEIITFFYIYMALTLCSLILDAGVVPPGSSPFPYFAAVQNGLASALCTSLLINGFVGFQLYEDGTILSVWLLRLSSAAMFVISFLVSLATFKAWGGLGPTNTVGMFVVLYILNAICIAVYLVMSLLLVMNTLEDRWPLGHIAFGLVVFICGQVLLYAFSDTICDSVQHYMDGLFFATFCNLLAVMMVYKFWDYITKEDLEFSVGIKPNTWEVKELLPDEDRRQTGYYADANSEYAGSMYHHRTSTYHGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0V5</accession>
    <name>A0A370Q0V5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DC-UbP/UBTD2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_261380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0V5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="32805" checksum="6DE68E678A32FC0C" modified="2018-11-07" version="1">MGCCFSLSRDYSRPSYAAQVVTEERRSEDIHPQAAATSNALTSGNSSARARGSRIRAEHFPLNQHYNAPIRRHVWYSKRRLWTRTQLDQERTEFFETRVTGRSEIWAALSAAISLMRAGDLATAQSFIDAAGITVPTGDLCQGCYDEQGVLYRLPQCIVSDPENIVRSDQEPDDFDTDDGKLSSDEASGDELIADDIERRRDEKGKTSERDLIRIRARLSDRGGPDIILSVVKTMNVGSIARKVQQEAGIPRTHRVRLVYLGRMLKEHVPLVDQGWNPAHVISALVVPRQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1C0</accession>
    <name>A0A370Q1C0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1C0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="285"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="461" mass="52491" checksum="B1AF1A5DA83546ED" modified="2018-11-07" version="1">MSEPRSPEPELKPAAEVDEQQQQQEAPPTPGGDAVSDEEPAKEVEAEAEPEAEEQQQEQEEQGEEEAAQDNGGDNDDDDDEDKISDDESILSEVDEAQFEDFDPENVDIEDRPQLAIDEDNLKLIGRHKRKRTEGGDEERSKRKREGRREKKSRRMRELEDGGASDEEKASRRRKKKEAEIADEELLDPATRRRRALDRAMDEALKKPTKRRFRKADGIDLEQMADAEIEDMRKRMTHAAQMDAINRREGKPAMHKLKMLPEVVSLLNRNQYVNSLVDPEINLLEAVKFFLEPLDDGSLPAYNIQRDLMTALGKLPINKEALVASGIGKVIVFYTRSKRPEPGIKRMAERLLAEWTRPILQRSDDYSKRVYQEAAFDPTKLSATRTQSVQATAAEARARELLPPRLANRARADMTHTSYTVVPRPTMVQESKFARPLGASGEDRFRKMRARQIAASKGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3H1</accession>
    <name>A0A370P3H1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3H1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34737" checksum="EAD43291FAFEED62" modified="2018-11-07" version="1">MATWAYPPVPPERLEQEVDSALAKELEWLLRSLQDSLTSLREGLHECAALLAPKEPGSTLVLSSLRSENVKGFVTRVGTKIVKGDIQLRLSSLASRGSATTRLCLANTPTTPELILSQLVSVKNLVNQSLDIVDVSTWTGDPLNAGFIYSQLHLLRETISEARQMLKGENDKVRGKWWETSAQEEMFDPPLPAYLSFHLSIADSALVLYLRTLESNTPVHTPTAFATDISLTGFNLRDRLFGSRHRPHDEAGDVFTWKGDEVKVREKIRVESQDPSLMAVMAKLTALEHEVMKWISALKVLMGNEDTDSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4P1</accession>
    <name>A0A370P4P1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_310829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4P1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="511"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111918" checksum="D9B3841298BAB1C8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Z1</accession>
    <name>A0A370P4Z1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_310657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Z1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="443" mass="47561" checksum="9995B6699912BCF4" modified="2018-11-07" version="1">MTIRYLKSKSQSPNSAATPQVDVSGVVKGVIDDVRANGDAAVRKYSEKFDRWSPASFKLSQADIDAALAACSPQTIADIKEVQKNVRAFAQAQRDSIRDFEYEIQPSKGVHLGQKNLPINSVGAYIPGGRYPLLASAHMTILTAKVAGVPHVVGCTPPIAGQIPHATVAAMHLAGADEIHLLGGVQAIAAMAVGTETIRKVDFLAGPGNAFVAEGKRQLFGEVGIDLFAGPTEILIVADETADPFTVATDLLSQAEHGPDSPAVLITTSERVGRAAIDIINQLLPNLSTRELAGTSWDRFGEAILVDSLDEAWRLADEYASEHVQIFTKRPREALEKMTAYGALFLGEKTCVSYGDKVIGTNHVLPTKKAARYTGGLWVGKYLRTVTYQEVTSSTASGELGRLCGRAARAEQFEGHARSGDLRAQKYLGDRYDWIASSDQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5E6</accession>
    <name>A0A370P5E6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_310179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5E6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="28503" checksum="F5C6ACFB79A6641F" modified="2018-11-07" version="1">MSAPTTVIFVPGAWHSPHCFDEVVRLLQAEGYNTDLVHLPSVDPIQPHSDFSVDVSHIRNQIQVAIDAGQRVVVTVHSYGGLPGSEAIRGLDWSTRQRQGQPGGVIHLFFCCSFIVPAGKSLISSFGGQDLPWFRISDDRLLVTPATPRTTFYNDMSPRETESAVQTLRPHSYQTFHSKLSYEAWRHVPSTYLYCLKDEAIPLPVQRMMVEEIAKGVNIHTHVVNASHSPFYTAPAEVADAIGKAASRSAELITDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5N6</accession>
    <name>A0A370P5N6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_330691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5N6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="257" mass="27789" checksum="22C229B3F7AB2951" modified="2018-11-07" version="1">MSTTTTTTALTSTTLIGTLPSMAGAAALVSGKACPTCGQDGLLAAGQSTTDARRRAKDLEGQVNALNLQAMQMAEKLAAYEEEIRRLRAQSSSRNNTSVSSTASTQIDRSQSPTHLQTSPKSQPGRLSTLASFLPSRRPSATSTTQAQTVASPPPPEPVQPATSQEETVELQNALNREQSLRKAAESQLSQASTELEELTAQLFSQANEMVAQERKARARLEERVAVLERRDVEKRARLERLEKAMARVERIRAMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5P6</accession>
    <name>A0A370P5P6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_259351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5P6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="37589" checksum="E723FDEF70368706" modified="2018-11-07" version="1">MQAAQQSWEFENAVTLIDPHRDALYKYDEETHKALSAQRPWSKDPHYFKSIRISAVALLKMVMHARSGGSLEVMGLMQGYVLPETFVVTDAFRLPVEGTETRVNAQDEANEYMVSYLQSCRDAGRMENAVGWYHSHPGYGCWLSGIDVTTQDMQQLGGPFVAVVVDPERTISAGKVDIGAFRTFPKDYTPPKGEGGSGAGEDDYQTVPLNKAEDFGAHASHYYSLEVSVFKSALDTEILSLLWNKYWVATLSQSPLFTTRDYGSKQMVDLSQKIKRATRGVESSASRGNLAQVKDPQLERVARDGQRIVSEEVKGLLAAEVKMKLFQNVGEGDRSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5U8</accession>
    <name>A0A370P5U8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_279756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5U8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="283"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="554" mass="60190" checksum="F7788D4E1F534DA0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5V4</accession>
    <name>A0A370P5V4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_270859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5V4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="182"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="287"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="386" mass="43977" checksum="4A5EB55CF1CCCD9F" modified="2018-11-07" version="1">MLAPRLLRPASSLVRPFSSTATASRAPSIRDITPDSAVEFNARQKEFRENLEVARKKREQQESQSVDASGSTSAPSPASRDRLREYATAPTAPSESNASSNKHPVFDAAEVLDNKALGSLSTHRIIGDEQLQEASQSPKRGPLSSLIYGTKEGQQLDKDIERSFSQVLARGKYVHSIVFHDVKPDKVDDYVNLVGQWYPRMAADPENRVNLVGSWRTQVGDNDTFVHIWEYQRYEGYHASLHNISCHPEFPEFDRQLKGLIKSKKTSLMQEFSFWPTTPPRRLGGLFELRSYTLHPGNLLEWETHWRRGLKARREVMEGVGAWFVQIGDLNTVHHLWQFANLEERKVRREQSWGIEGWAETVHKTVPLIQTMQSRILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P638</accession>
    <name>A0A370P638_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anucleate primary sterigmata</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_224392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK37336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="562"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1531"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="61"/>
            <end position="139"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="260"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="511"/>
        </location>
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            <begin position="633"/>
            <end position="660"/>
        </location>
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            <end position="795"/>
        </location>
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            <end position="890"/>
        </location>
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        <location>
            <begin position="1439"/>
            <end position="1530"/>
        </location>
    </feature>
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        <location>
            <begin position="1577"/>
            <end position="1635"/>
        </location>
    </feature>
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        <location>
            <begin position="719"/>
            <end position="753"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
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        <location>
            <begin position="263"/>
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        </location>
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        <location>
            <begin position="1592"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK37336.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1635" mass="183304" checksum="133A830B1E6D5329" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6L2</accession>
    <name>A0A370P6L2_ASPPH</name>
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        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">M752DRAFT_321767</name>
    </gene>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF00155"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Z1</accession>
    <name>A0A370P6Z1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-glucanase/mutanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_297968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Z1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="102439" checksum="96469628A3732F8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P757</accession>
    <name>A0A370P757_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Sterigmatocystin biosynthesis fatty acid synthase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_308699</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 16" id="KW-0520">NAD</keyword>
    <keyword evidence="5 16" id="KW-0521">NADP</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="19">
        <location>
            <begin position="1612"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="17">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="17">
        <location>
            <position position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK37713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1995" mass="218340" checksum="D5DF664E356350A7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7F4</accession>
    <name>A0A370P7F4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_222658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7F4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="732"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="954" mass="107217" checksum="FD605E8BD65F50E9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7K1</accession>
    <name>A0A370P7K1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_297556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7K1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="270"/>
        </location>
    </feature>
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            <end position="306"/>
        </location>
    </feature>
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            <end position="330"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="55473" checksum="57D66C9F6E902704" modified="2018-11-07" version="1">MKKPQGQVLCILMTITCGVSYLLYGYDQGFMSGVLLAQDFLQTMDQPSTFMQGLLSSLYTLGCFFGCVGSISFSEKIGRKNPILIGTILISIGTVIQTAAYSPAQFIAETLPAKKRERFGAIQYVLVCTGTTISYWMAYALSYSANSAFQWRFLVAAQLVFAVLIMCLVPLMPESPRWHFVHGQRDKALCTLMRMHGTSDEQQSEVQAEVHLIQQAMELEARHGATRWADLFKNEPRTQNLRRLMLGWWLMFMVMWSGVCSIGYYISYLFEVSVGLSHNLSLLLSGFNGLWYLLSAFIPFFVINHLGKRRCMMISAAGMCCCFLTMSLTIRSGTFAASIVCIVAFFLYYTFFALGYLAIPWLYNAEIMPLHLRSQGTALTTSSNWIWNFATVMMTPSLMSQQGWKGYLVFTVFNFCFVPVIYLLYPETTGRRLEEIDAIFYGTSVLVARTEWAEKGRFEANPLGGVIQGLEPSQKETQHHVEYVSSYSENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7L8</accession>
    <name>A0A370P7L8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_339140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7L8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="238" mass="26285" checksum="2BCFA56D9294D64E" modified="2018-11-07" version="1">MSSPKIVLYTNRTCPWAHRAHIVLQELGLPFEEVTIDLDTPREPWYLEVNPRGLVPSLSYNGEVITESGIVAQFLADAHPSHLVPPSNTPEGALQRARIAFFVDTYSSKAAPHYNAALRGATEADRKAGVESYVAAIKKEIEPLLYQGLEGKQHGPFFGGSDKLTLVEVLLGSFLIRLHAFADKEADLIDPAIWEGLAEAKNFSRWAQATREHPSVNGIFDAKACADRTKKKLLANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M0</accession>
    <name>A0A370P7M0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_308052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="36"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="916"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="916"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1269" mass="137826" checksum="8B2A944A45D98128" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P808</accession>
    <name>A0A370P808_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_297281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P808"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="65" mass="6799" checksum="C9F8482ED6BEFF91" modified="2018-11-07" version="1">MTGYCQKAVDTMLPGLVFDTNGGRTGNCWGAPDGLGYGVFVAGPGGCTRTTEQMKAAFNNIRAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8H6</accession>
    <name>A0A370P8H6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_257379</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
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    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016654547" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK38482.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="573" mass="62481" checksum="F86BA9E9893C5B09" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P906</accession>
    <name>A0A370P906_ASPPH</name>
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        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278886</name>
    </gene>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
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        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="377"/>
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            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="45649" checksum="364C65AF32310864" modified="2018-11-07" version="1">MKILISGAGCAGPALAFWLSRTNHQVVVVERFPTLRDKGAQIDLREQGIEVVRRMGLLDTIRQHCVHEDGFTLVDGNDHVTAMIRPNTSGQGAQSFSSEFEIMRGDLVRILYDATKKDVEYRFNTTVERFEQDDEKVIVNFSDGTSETFDLLVGADGQGSRIRRGILPPGTVDPYLHLGIHAAYWFVPREKGDTNTFTTYISPGGRAIFRRSHSPTTSQVYFMLKSDDPALASIHRAAVDAQKEFWIRQYRGAGWQTERFIEGMKTTDNFYSQEIVQVKTEMWYKGRVVLLGDAAACPAVVTGMGTTGCLVGAYVLAGEINRHAGDVGAALKNYDATLRPFVKEIQKLNTSVVRLFFPTSWWGIWLLHWFAAVVCFLRIPELLDRMGNEEVGGWKLPEYEELRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P935</accession>
    <name>A0A370P935_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P935"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31113" checksum="D425EE55BE191545" modified="2018-11-07" version="1">MSDLLKSRWAPSPSELQAQAAAPSTARPKFPPTTNTKRTPSPVQRPSRQSSPRPSPSNHLSRFMKIVERLKWKLPYLAYGYRLATLDPATSDFDVSHAEIMFKLDFHEYYSLLERAIVHLLSVFGISVSSAFARNHLAAYESAPLSTHRFHANVLEALQDENSPLHAVLGQGEVHEQLQRAKELRNRWKTADLTKEELEREDKWAARRKGKAMPLASYDIEKILSDIFQGFDDAYLIAQEHVVACDGAVKMDVALHGESDADWDFIVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y0</accession>
    <name>A0A370P9Y0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_58335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="21870" checksum="0C3B4A5DB2CD3507" modified="2018-11-07" version="1">MRKGGVSREVGREDTCQTGTYKWKKQPGCIKKGQHGRLSLEADLQHHARPANDGHEVASLVAFPAGSVTRPPGLGWKDGQRGRQWKQVRDVSRPPPSLEELEEYYWLSNLPSFHYCTKPKAYPGFQPMEGLLGRAITGAEAVAIAILGSQICIRDWLQRCCSWQVEMGDDALRPHIIRGRPKFCQGSRSIRHARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA11</accession>
    <name>A0A370PA11_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_220751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="271"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="436" mass="48654" checksum="4A812E65C9EF6D76" modified="2018-11-07" version="1">MTFAAETSSNGNSRCQSSGGKADHLQQAFVDDNVAISPNAPEEVPTLLKRIAMHGEAYLTESDENERTRILDAARSLVYALETPREAIIRHCWSQSTLYAAVETGVDLGIFTVLSQDDKPKTAGHLAAATGADPTMIARILKHLAAMGVITETGPDEYRRTGFSIAMMSNRYSDSYPCMTGCITDGVLALPAQLKKTNYRNPSDGKNCAFQRGFRTPLHFFDFLEKNHIHAIQFNNHMSAYHQGRPSWMDVGFYPVLSLVAEANISDQDVLLVDIGGSLGHDLSEFHRKWPQVPGRLILQDLPKVVEQARSMDLDPAIELMTHDFFTEQPIKGARAYYMHSVLHDWTDDDCRRVLANIIPAMKPGHTKLLLNENVIPGTNAYWETTSLDIIMMADFASTERTEKQWRALVESAGLKITRIWTVRRGVESLIECELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA87</accession>
    <name>A0A370PA87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016894175" evidence="3">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="42936" checksum="A1E8FA816538CF92" modified="2018-11-07" version="1">MAPSFLALTTLLAFLLTVAAQIAYDPETNSLLCSKPGGSYCASGSLEGPTIITCASQHTVEISSCNIFLKDLLPEGYEEKATCYETTSWAGDALCAFNGTGYALIKKSRDVVPVSVPETVLCGDDDENDPQTWDDSNDEEDAFVSYVDDEDDDAEDIFDPYVEDEGDDAEDTFIPYVDDEDNYEDNDEDDEKEGEGRLLFAPKEDTSAGPTLPYPPLLPATHPRKTASTSGPSSTLSTLSTLLSMTSSPSSATETAAMQEVKRNIRERACSDPWKIPSSSFSIQDMGFSTISSTSTMDSTTAGSGHRQPLSTFTSTIYASRSAGVAANTVTITTTESGTPTSAGVWDDNPEKESTPVKTSDASHTSESGSEMHALEDRIIFQDLAILWVLWVVLAYIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAK1</accession>
    <name>A0A370PAK1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="272" mass="32290" checksum="EA752882EBC62D52" modified="2018-11-07" version="1">MHTFSGPNPIPTEVIINIFGELSLPDALHLAATCRRLRQVLSEHTPTIYKRLRRKIPCERYARVLLADQGGLALYSSSVTIRDLLRLRRNSRMVEKAIEVFDRDITPNIRIPLTSIDDEFYGGKPRPLHLLPSERHRFTRSYYQFWSLSLLDRPSRQQRYQRMLLKHLYMVYEMVDLNQPIGDELVSFFADEKRCELSQELTDYLHYLYHDIHGVDYIDFSGHSISMRTRGHAAIWDHCQPDFKKIVCYQWRDPEKKPVKEEEVWEHTTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAZ7</accession>
    <name>A0A370PAZ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_54922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="75" mass="8271" checksum="3D788248CEF3D161" modified="2018-11-07" version="1">MALDGGKSLTGFTKKVGESGKGKRRNDTHTHTSSYATQQVDSRGTISYSTSRNRRRLATANNTQHTTEQNKQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBG3</accession>
    <name>A0A370PBG3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_278046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBG3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20672" checksum="ED65F85ED5E89D06" modified="2018-11-07" version="1">MACPITVSKFVGTVSLGLLTGMSYSASSVAIPSLSLLPTASTASRSLNEVKRLNRKHGLRLTNIANGCFLFAYCLSSRQRKHPYLIWVCVTSTVGSYAFDYLFHRQDGFVAWIQSVLQDTGCGFLTVQKQKKEEDIVVVEAEENVNGESVQKEMNTERRFQQVRAVFSGIALAMGIVGLWGDRRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBR8</accession>
    <name>A0A370PBR8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_255358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="226" mass="23844" checksum="A14E3FBC04115F02" modified="2018-11-07" version="1" fragment="single">MPTSKTKTILITGCSAHGIGAALALTLARQGHFIFATARNTTKISESLKRAGPLLDVTDSATIADAVRAVREHGRGLDILVNNAGTGYTMPLLEADLDRAKAVYAANVWGLLRLVQACSDLLVEAEGRIVNMSSVGAVVNTPWIGIYSSSKAAINQLSETLRLELSPLGVSVLCIMAGTITTDFHANEPEVVLLPTSRYAAIGQTISDWATGRAGPKAVRRMSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDV7</accession>
    <name>A0A370PDV7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_277668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="604"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="815" mass="91976" checksum="7E11F5D17DF732C0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE17</accession>
    <name>A0A370PE17_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_254514</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK40438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="58621" checksum="292B76069E1A763E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE57</accession>
    <name>A0A370PE57_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_303699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="312" mass="36684" checksum="1700B4035121A531" modified="2018-11-07" version="1">MGVKRSFESFIENSREDAKLRVAQTNVVSRHLSHIFTATKALKHSVLTEHDLDTLGIKLSEHDLEGECSNGHQAFYQPLPKSKLPEIDWDKVHFSKWHEGHSDEPRWVHYTLQSVSGRVYGAWFRGGEHQTWVHRQCYRANPRTASGEHRPDVPYSWQTVAEMEADSLDILHCSFQMYHYADPEEPLRRSEVLPIVGFMRWRLNRFNYIKHRTFPVIVVSIFRSQARILQAYHDGEFLHISKSKFVDFTENWRENYELFVRWIYSLPCGDTVAPLPIKGEELPRRSYELIDKGFDYVAREAEAYHQPKKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ8</accession>
    <name>A0A370PEJ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_337138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEJ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="552"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="881"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115050" checksum="ABA61CEEBDD528BD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEN9</accession>
    <name>A0A370PEN9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_236671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="347"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="47828" checksum="3E5628F8C9E65D78" modified="2018-11-07" version="1">MTRFEFFAFPEYFQQLPLTNSCLGQLQDASGSYSPIRIGGTTQDRATYNASLSSAVSYSVDSPDDAPESLTFGDSFMEIAAAYEGAVTIGLNRRLDNIDNTIAAAKIAKSNIANLYAIELGNEPNFFTSSDPIADGQSWTAAADAASQVSWQASVGSALDETSFAQTGVFFGVGTFNVSNLAEKEEETDSTQYVRSFCHHYYPQSASTADLVELMSHTEIVEGVSEFQSQIVAAQELDKDFVMGETNSATGGGGGISPTFGAGLWILDYVMQATILGVKNNNYSSTKEQLATVRISCCCLCMVGRKLILGARPSVNAPFYGAYTAALALSGASKIAQLDTGDSRFAAYAFYDSSNQPIRVLLYNSEYYTSGTRSSVSVTLSGIPSATTSVSALRLTGDAATTIVGEGAITVGGQTFANATCELQGTKDMEATAVTAGRATFTVQASEALLISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEQ2</accession>
    <name>A0A370PEQ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_253820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEQ2"/>
    <dbReference type="SMR" id="A0A370PEQ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="541" mass="58699" checksum="751FCC4C7A39CABC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF17</accession>
    <name>A0A370PF17_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_328164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000467">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="274"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="435" mass="46911" checksum="58168C433A0A8F65" modified="2018-11-07" version="1">MSTTTIELAPQGLQESQSPVQLFGPSTEEAIVQQKQKWNDPPINKWRLLATFISFTVVGANDGVYGALVPYLREDYKLSTTVVSLIFVTPFAGYTIATLIVNKIHMTLGQRGIAIIGPLCHIIPYVIMAIHPPWPAMLAVYVIVGLGNGLIDAAWNSWIADMANANAMMGVLQAFYGLGATISPLVGTQMIKSGLRWNYFYYTLLGGSVLELMVSSTLFWKENAVSYRATNHRNSDSGNGSRTTEAMKSPITWLIAVWLFVYMGVEVSVGGWVVDFMVQVRHGEPYQSGLIPTGFWAGVTVGRLVLGFVNDWLGERIAISIYLAISIALELIFWLVPQFVVSAVAVSLLGFFTGPLFPAAIVVAAKLLPKHLHTPGIGLASALAGGGGAILPFVAGAISGARGVQSLQPFVLALLVALIAIWVLLPRNKHHAHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGA4</accession>
    <name>A0A370PGA4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_294889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="128" mass="14442" checksum="E2097A523EA0043C" modified="2018-11-07" version="1">MSITELQISESIKEDTEDETLIVTVSVQNNSSVDGHEVVQVYVRQLHPSLGRTVKELKGFKKVFVRANSKESINIAISKKRATSFRNARQGIWLSEKDTYQLLVGSSSEYIAQAANFEVHETQSWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGF2</accession>
    <name>A0A370PGF2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="11">DOHH</shortName>
            <ecNumber evidence="11">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LIA1</name>
        <name evidence="13" type="ORF">M752DRAFT_337031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="11"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGF2"/>
    <dbReference type="SMR" id="A0A370PGF2"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="36899" checksum="1F6CD7020D00D2AE" modified="2018-11-07" version="1">MSAVNENNLEGVSETVLTLRKVVVNESEPLARRFRALFSLKYLACLQPPSEDTLPAIEAIAAAFSSKSALLKHELAYCLGQTRNPDAVAFLQQVLKDKEEDVMCRHEAAEALGALGYEDSLEILKALKDDENEPEVIRETCDIAVDRIVWENSEARKAEKLKPSDFTSIDPAPPMPLEAAEPSIPELEKTLLDTKLPLFQRYRAMFALRDLASPPDLPTAVQAVDALAKGLKDPSALFRHEVAFVFGQLCHPASVPSLTECLSNQEEAGMVRHEAAEALGSLGDVEGVEDTLKKFLNDPEQVVRDSIIVALDMAEFEKNGEMEYALVPDSGAPAAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHF8</accession>
    <name>A0A370PHF8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_276990</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="399"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="572" mass="63922" checksum="2C792B4E827A56FE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHM7</accession>
    <name>A0A370PHM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="14331" checksum="5FB4468D01924119" modified="2018-11-07" version="1">MFKLQLEVRGNDGKSDEQNDTDTTNKDKKALEEARKNARRAESYIKRVRNQLGWDVREFDLQRLRYIRRSSYLSPVLCGQDLFTIITSILYKNKHEPSTIHHAIARLAHAQYMPDRQSLQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHN8</accession>
    <name>A0A370PHN8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_302250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="411" mass="46262" checksum="8050D2B8EF6B4437" modified="2018-11-07" version="1" fragment="single">QNKHQLGDQWNGENLSIFSLDDLPLPLSPTAASLFNESTTSLIQHRGVNMRESLDKSTVNPGNLKTKLRTPSITSRMADVPELTSNPGFRAAEAYVRPSPVAITGVILSYGFDLRNYTFTLKLLGHETGPDAQTTDISLPEFHFPKNKCEVEVTSGKWTITTDDSDNCSIQRLRWWHQDGEQTIKVTGVRMPHHGSSSGPIMLPPLPHALGIVPSFCVNGQKTLVMKEKVWALAQGTFQIRDESNVELLQCKAKLFSLHHQRFFYDMQGNELWSLKHKPLSIPRQYYGEGPDGREVFHVQGQWHLGGARMTVSFVNTAGNSEHIELALSGNWIDRYCTITWNDRPVAQITRHYFNTRQILGDADTYYVTIAPGMDIALIVSLCVMYDEEMRKERSNEGRLLKVGVLDPRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHQ0</accession>
    <name>A0A370PHQ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_29135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHQ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="115" mass="13578" checksum="713975F8F6FCACFD" modified="2018-11-07" version="1">MKTVLGILHYQGDREDQMNAERLAFIAVHCDKYICTTALRPWIFKWFHDCQPVRTDEEYGYLLLAAHLFRDNDQFSRLSASAQTRLSPKFLNKWQEIDILKFLPDAIGGMYPFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHU1</accession>
    <name>A0A370PHU1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="21855" checksum="84FA6829ACA3454E" modified="2018-11-07" version="1">MPHSVHHRRRHSWPYCGPGTQLRERRNLPLIIAEQQRQFEQQFLTPVGSEDLLEDDAASAGIVRSRTARTHRRWYAPWDSASSGAPSQVTGHHAGSGSGSLRKMIRPPLDKARSLFVLPTTTTTGESVLVSYWMPQEASVLPPSDSIAERGRVADVKSGAGYLSVERYHRRCHSEQPRSWKRPSAALWPLEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIT5</accession>
    <name>A0A370PIT5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_336462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIT5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="189"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="35011" checksum="7A74EA0B0EFBED0B" modified="2018-11-07" version="1">MASQVDVLLYGLGAIGSFYAFILHRSNKVRLTVVARSNYAAVKENGILLKSANHGEHRFYPDHVVRSPSELTHPVDYIVCTNKAIDPASAVHSLAPAIGNDTTIVIIQNGVGNEEPFREAYPSCSIISCVTWVGASQPTPGTVIHTTSEDTELGLYPNPKVSDAVEAGRLNTFAGLLAAGQTRHTVHDNIQPTRWSKVIWNCAWNTLTTLTALDTQAFLQSSPDAIPFTRRLMSEAVAVARAAGVPLPDDLTDTQLARIQSLGAVRTSMQIDRENNRPMEIEVIVGTPVRKGRELGVPTPVLETLYVLLRAVDGETRRAQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ43</accession>
    <name>A0A370PJ43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="3"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="447" mass="49906" checksum="9532F3B8D88C8F4A" modified="2018-11-07" version="1">MPSIKVFTRWRPALPSESQAPEITRTQESNPGKNTTIALTPPPSQKLSRPWKSDSAFTKIFNADDSNRTVFEHVVAPTLPRVFSGQNCNFFAYGHSGSGKSHTIIGYNFEHPEEFGLCLSAAKALFEQLHQLNEKSKENERLLLGLRMYELRKNIAFDLLNDRCKCHIREGADGKTHVRGETETLADGKVRVRPIVTKPCFTFDEFHAQLRAGIQSRATGTSTIHDQSSRTHAVFEVEIVTKELLDARDAVVERQSELVPVGKRATDIYIEENTKAIIQTPDGKYVPNPDYQLNQAAIDEAEAKKAEFESRVQEAEDYVSEVKKSCPHACLGGKMVFVDLAGSEYCHDKGSVSTMRTKQTPQEQQESRQINTDLLALKEVIRAMARKQSRIPFRSSPLTMVLREHFVTGGDDGVSAMILTTSPSSEQYNATIDTLKYGNLIGMAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ93</accession>
    <name>A0A370PJ93_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_319175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ93"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="330" mass="37684" checksum="FFF84F5DCFCEF95D" modified="2018-11-07" version="1">MMATSASTDKPELVSWEVHRENKFVASVAKVLTYHKIPCVLIGQSYHKIIGIPSKIHMLNLDQTISFAVEDGDLERAGKLLDEEGLSRQCKNGSRCRYSQARFCFSTPEPDLLFHVDVVQGRTPLPEAGHLSLFSKDKWLPHVPALNLGPPSDSNYFILANDRRLPSWCEEHRRARRDGDRVTASKCVCGLIVESEYTGGRYRDNLPPVNILRPARLIEMWVRSQFNEWLIEYHRDGEAGEDQGRFWNGLYSFEAYSLWNPSAFEPEYRDWWTYVRLTVDWVRGKAAPGRRDAAAAAREARVGLQRNREQLIKRLKDSGKMLPGIGVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJT2</accession>
    <name>A0A370PJT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNVH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF8">
        <property type="entry name" value="RICH PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="251"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="39098" checksum="B8B0EA78AE92300C" modified="2018-11-07" version="1">MAAQEYFGGSSATPANPDRRQQNPSPWSSPAVDTPSSTGYGSYPPSVENGQDRYGSSSPYPPQGAGGYNRPYSPYQPHSPQPGYQNPEYSSYGGRPPYPQHEQSSPYGQPPSESRPYPPYPQHEGYPSHQQPPPYSPESSTDPAAAGEGDKGIMGALAGGAAGGFAGHKVNHGFLGTIGGAMMGSVAEDAVKKHKEKKEHEEEERRRMEERRRMEEHYRMEEQRRRDEQQRMSQQHHHRPPPHHGAPLRGNFSASSRDIRLESHHDLVAACGRVSGELQLSVLPLNSVLANHWGKFAWERNGNFAASARNVRLVDGGRVLEAELADGNDGWNRTWIRLDERITNQNGQLMFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK97</accession>
    <name>A0A370PK97_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_276465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK97"/>
    <dbReference type="SMR" id="A0A370PK97"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="358" mass="37912" checksum="8EE8466F840C9399" modified="2018-11-07" version="1">MSTQNTNAQNLSFVLEGIHRVKFEDRPIPEINNPHDVLVNVRFTGICGSDVHYWEHGSIGQFIVKDPMVLGHESSGVVSKVGSAVTSLKVGDCVAMEPGIPCRRCEPCKAGKYNLCVKMAFAATPPYDGTLAKYYVLPEDFCYKLPESITLQEGAIMEPLSVAVHIVKQAGINPGQSVVVFGAGPVGLLCCAVAKAYGASKVIAVDIQKGRLDFAKKYAATATFEPAKAAALENAQRIITENDLGSGADVAIDASGAEPSVHTGIHVLRAGGTYVQGGMGRSEITFPIMAACTKELNVKGSFRYGSGDYKLAVSLVSAGKVNVKELITGVVKFEDAERAFEEVRAGKGIKTLIAGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKE5</accession>
    <name>A0A370PKE5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_335447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31881" checksum="E17924749AB2FDD3" modified="2018-11-07" version="1">MGQKTVLITGCSEGGIGDALARNFHKRGFRVFASARNTEKVEHLKKMGLDIVQLDVTDEESIKKAVSTVKAATGGYLDFLVNNSGAGYCMPLLDSDSSVAKKIFDVNVFAVVAVTQAFALLLIGSKGTIINIGSVLGKMPLPWQGYYNASKAAVAILTDQMRIEFSPWGVRAILVTTGAVRTKLFENLPSKPVLPEGSLYYPAKDVIEPVLTGAGVEKNAMDVDQYAEVVVNNAIQSRPKKHVWSGGGALITWLASTFGWSTIWDLLLPPVVHMSDILNKIRTSEKAEHECRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKP9</accession>
    <name>A0A370PKP9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_335526</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
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        <property type="protein sequence ID" value="RDK42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A370PKP9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="404"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="404"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="537"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="582"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="674"/>
            <end position="677"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="783" mass="85760" checksum="7BE3F6B553F06304" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL35</accession>
    <name>A0A370PL35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_214177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000104">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="59201" checksum="AA02DBD907248C03" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLC8</accession>
    <name>A0A370PLC8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_165721</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="297"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="443"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="571"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="681"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="769" mass="86852" checksum="B92B7D5A765704E4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLQ5</accession>
    <name>A0A370PLQ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rtt106-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_293296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLQ5"/>
    <dbReference type="SMR" id="A0A370PLQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="254"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="458" mass="50310" checksum="053AEFE3FBD85B59" modified="2018-11-07" version="1">MAFATINSSVPSSIPAIEDAFAAEPALKKRVYDAIAHTPQHGLLFEDIAKYTSSLLARTATAPVRPVEVVSDGPAMKKRKLQNGNATSAQSSGDLKSDTSLQFYMQDVSFAVPQRKKLTLEVTAGFLRARNQTSKEVEFGVPLDNIQHVLCLPVPEKNQRQFNFCIIPQYADGVNSPPEGVAAPDAIVWTVNDGPPKAAFSGNGQQLGTDNEETADKLVQRILNDSLPRTKVVRPDEREFVSAMPEAHRKGEKAFHVKAFRGSKEGYLFLLSTGILFGFKKPLVFFAFENVDSISYTSVLQRTFNLNVVARPTSSEETQEFEFSMIDQADFSGIDGYIKKHGLQDASLAEARRAKRYNVNGAKGEDEAAANEEGAVEEESELQKAQRELEDQEDEDEEDYDPGSDSDSDGSGSSSEEDDDDDEEDDEGDMEEDDEEGDRNLVAEELGSEAEDVPAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLU3</accession>
    <name>A0A370PLU3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_293044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="12621" checksum="6AEFAF840C92A459" modified="2018-11-07" version="1">MDPRLVTDRRSKRFLPKKRLRKLLRNNIDGITRPSIRRLARRGGVIRISADVYPEVRKTVKNRLTEIIRQIILVMESSTTPGHERKLVRTQDVVFALNRMGHTLYGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM00</accession>
    <name>A0A370PM00_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_154037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="333" mass="36791" checksum="162BB3189FC4F724" modified="2018-11-07" version="1">MTSSAEGPMQSPPLPGDADAPPTFQEWYSFDALANCWSLLPSSTPVTCDESTMPASDKAKLKHPALNLVTWNVDAFAKFPDDRMAGIISTIRNQTPPPNILFFQEVPKAALFYLLNDPWIRENWYSNEGNLSNYGGHVFMTVILLSKLSFGRDSQEPDKACIGPVWRVKYRSKFERDALCCDVFMPPFATRVRLVNVHLDSLALQPSRRPRQLAIVANSLRCAGHGFVAGDFNPVLPEDDGLVAANGLVDVWNELHPDEPGFTWGLDGREPFPPGRLDKVAVLGLKGQEMDILHPGALESAGQGLLRRQLDTPVPWSDHSGLKCCLRLAEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMM7</accession>
    <name>A0A370PMM7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_318594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="295"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="838" mass="93637" checksum="166474C0D9311F25" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMV2</accession>
    <name>A0A370PMV2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_314763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="543" mass="62124" checksum="21A3BFACCFF06BC0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN10</accession>
    <name>A0A370PN10_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="138" mass="15965" checksum="1BB6748BA2B62524" modified="2018-11-07" version="1">MSSTTPQTDSTTPKPKYNLRNPLPLSAAQEAEVKQLYYKRVRSLCAPEIKAFAECAVNRTITATWVCREQRLAMNACMVAHAKPEEEDRAREEWFATHEERRKAKEEELAKVEKRREEVIRMMREDQARQAAAAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNA3</accession>
    <name>A0A370PNA3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_313508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="897"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="964"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2755"/>
            <end position="2776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2795"/>
            <end position="2835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2761"/>
            <end position="2776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2879" mass="321789" checksum="F1203ADAA480B853" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNB2</accession>
    <name>A0A370PNB2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_156517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="116" mass="13291" checksum="76EE003D4E933068" modified="2018-11-07" version="1">MDSAVTHTPNYHSLCLWFYISPRHDTTNPIAINNNPQVRSPQSVNLSSAPRPHLSFKFVPQKSPYPSPSHGKKRKEKEANKRDRLPHKPLHKPRPEPNPLIMRTGGRQLGEDIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNI6</accession>
    <name>A0A370PNI6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_275054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNI6"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="38070" checksum="553BA9077A009EE2" modified="2018-11-07" version="1">MSTDKITFLTNWHATPYHAPLYLAQSKGYFKEEGLKVALLEPNDPSDVTEIIGSGKVDMGFKAMIHTLAAKARNFPVTSIGSLLDEPFTGVVYLKDSGITEDFRSLKGKKIGYVGEFGKIQIDELTKYYGMTADDYTAVRCGMNVTKAIIRGDIDAGIGLENVQMVELAEWLATQGRPRDDVQMLRIDQLAELGCCCFCSILYIANDAFLAANPEKVQKFMRAVKRATDYVLAEPARAFEEYVDVKPIMGTPVNRKIFERSFAYFSRDLKNVSRDWAKVTNYGKRLGILSADFVANYSNDYLSWGLDADSTDPLGDQKRMAELQKKVAAEGGYKRLEVASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNW7</accession>
    <name>A0A370PNW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_292058</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1890"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2151"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2288"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2292"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2332" mass="259235" checksum="76F550802AB6B1AB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP67</accession>
    <name>A0A370PP67_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_334824</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP67"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="297"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK43980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="60418" checksum="31931759FD056A70" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPA3</accession>
    <name>A0A370PPA3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_313974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPA3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="156"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="53945" checksum="D6D8807F9DB13947" modified="2018-11-07" version="1">MSKLSNPVSLLAAILVRVPLVLKTILLHAIRLSPVTGKQDLRTELTVAIIRSFLVFTSPVGKQQRDSMRDPGIKGPMWVSKVTFPKPEADVQDAVVKAIEALKTGDETYTIPGVIPLEAEWTGYRSGVHKNAPQPDISEEAKYEELKKESKEDMVILYLHGGAYFLCDPCTHRPLVAQLSKRTSARVLSVRYRLAPQNPFPAALVDALTAYLSLVSPPPGSLHEPVAPNKIIVSGDSAGGNLCLVLLQTLLTLRRVCPTVRFHGRDIPIELPAGLAISSPWCDITRSMPSVHHNSVYDFLSPPTQDPETAYRPLAVPEDDVWPVKPPRVDLYANASALLHPLVSPLAGRDEIWKGAPPVFIAMGEEGLTDEGLVVARKMHRAGVPVVVEQFEGMPHCFGQVMMGTPSSRRFLDGTAQFCRDVVAGKITADTPTPAKITFIGYKLQSIREIPLESAVPLTDEEVDAVLERGKQWRLEGEKLLEQEWVEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPF6</accession>
    <name>A0A370PPF6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_264969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="30161" checksum="0CD247CE38522F0E" modified="2018-11-07" version="1">MIYQTIFTHLLEKPFGFLDGKRDATDKIGDLSFSERVQYLYERYYESSPVNAMWWRMVTLSLANLKEDDTFKSPRDKTPYEFGDRSRKRQANMARDLADQLLADSLFQLLLRELAGAEEETARRERLVTIFQDSAQAFINHEVILGGQVKIHQLPELKQFDTSTGLMFSMKLHCNKQEDHPLYVPKPRGRVILVVRPGVCRYDTPIRFIPFSHQTLRLKEVEGEPTSWLVCKAEVLMETVKASSSSDEYEPDPEDKDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPI7</accession>
    <name>A0A370PPI7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="15732" checksum="5755955C5C529B8F" modified="2018-11-07" version="1">MAPKKTAGAAKENVSLGPLAGDGKLVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPQ9</accession>
    <name>A0A370PPQ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_326028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000048">
        <property type="entry name" value="Protein transport protein SEC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="45739" checksum="8B6123243A781881" modified="2018-11-07" version="1">MGRFGFKKSGDDDEDSGNRLALFGSRSKSKSPAPPANPYAKPIPTDPYTKAKMQAGVAPLPAGEQPPAAGPSGAHNIPGDNKYQGYAPNRYGNQGGYGSDRFGGGGPAAPAASRYGPGGYGGLGSADPNDPAAADGNRDALFGGARDRAQQQQQAGPPPPYSEGGAAYGGGSNEYNTSTYQERHLTAEEEEEEEIQTIKQDIRFIKQGDVASTRNALRVAAQAEETGRETLARLGAQGERIHDAEKSLDVATVEGRIAEEKAKELKTLNKSMFAVHVSNPFTSSRRRRERDERILNTHRAERETREGTEKEAFKTNQRMERTFRDIDKEAAKQTTRNRTNITDRAKYQFEADSEDEAMENEIEQNLDLLGGAASRLNGLARATGRELDEQNRHLERITAKSDFVDDQIAMNRAKLDRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPX6</accession>
    <name>A0A370PPX6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_136473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="21681" checksum="60595FB7D2F38DDE" modified="2018-11-07" version="1">MFILTTVSDLIQISPEDFSKYSAVALEDNINEKYANKVIQKIGLCIGFYDLLESSDGLIGHGTGLVNVNVKFRLIVFRPFKGEIMLGKISSATEHGIKVAVEFFNDILVPPDLLLDGARFDYADQVWIWENEDGSTFYFDVGEVVRFRVEMEEWHDQIPNAPDLGDAAAIERKPPYSIIGSMQMAGLGPISWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ43</accession>
    <name>A0A370PQ43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_211814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="110286" checksum="81511535A00B487D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQJ2</accession>
    <name>A0A370PQJ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_291609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="436"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="59217" checksum="0A6D312B0CC69474" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQP5</accession>
    <name>A0A370PQP5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_140978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19998" checksum="3E97A30449F69DB1" modified="2018-11-07" version="1" fragment="single">HPKRGTGKLKEQKTSEHLGRFFEHPSSQQQTAKMGRVRTKTVKRSAKVVIERYYPKLTLDFETNKRICDEIAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDVSQTESGQLDVDSETKDLLKSMGFDNLKVNVIPVSQQQAQERPRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRJ9</accession>
    <name>A0A370PRJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="28339" checksum="52112FE82683D58C" modified="2018-11-07" version="1">MHMNLSPSGKDSRATSPPYVEFHDPFSAASLAYQPQKPLCLNMDTETSPGRPEPPALAVPMTPSSPSWPVHPEPCQIQGQTFMRTGTEEVPEPTSDLCPDLLDSWYPRYLACTQFFVSYAQHTPTVQSLAAFLNIRLPCQQSGAQTTHPSLRAYIRRLIVTAQDSPAVLSAFFGEDWVGGVGSMIKQERVNYLFTAKSGGWASTKAAYDILPDEQTPFLRPLRAATEEELREAEARWSEWLAMEDWMVGSRSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS43</accession>
    <name>A0A370PS43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_312771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="639" mass="72889" checksum="DB583B09060DE034" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT69</accession>
    <name>A0A370PT69_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2/Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="20894" checksum="4941A9F857154C25" modified="2018-11-07" version="1">MSYYFTILSPTDVPLFNIAFGTSKSGGDGIARFRFPDTAQYMNQFIIHSSLDIVEEAQWMNGNMYLKHIDTYPPASAYISAFLTPSGARFLLLHQPPQLASNSGQGGSGSGSMGGSMSGSLLLGSSGGSSRASASSIANNPTSPQTEEAVRQFMTEVYENYVKTVMSPFYRQGMEIKSPVFRGRVTAAGRKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT96</accession>
    <name>A0A370PT96_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_333262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT96"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="31401" checksum="78C9EFCD141A6D7A" modified="2018-11-07" version="1">MGSLLTQDMMSVKGRVALVTGGSSGIGRMIAQGLVTNGAKAYIVALPGDPIDQTVQDLNACGIESGGSAEGYACDLSSKDSIYQLAKSISQKETKLDMLISNAGIRRDPPIACNVLTATLAELQESMWSSRESDWADTFRINTTAHYFLSVAFLPLLAAAADQQLDDGRRGQDDGRGVVVITSSCASMHNATNVDLTSYAASKAATDHLVKLLAAKFHRFYVRVVGINPGFVPSNMNPVGAAGNMFSGLFDKVPAKRAGRVEDLAGAVLYLVSRAGSYVDGISLCMDGGRILLANGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTB6</accession>
    <name>A0A370PTB6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage-gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_210267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="913" mass="99531" checksum="46129E0BD96F92F9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU85</accession>
    <name>A0A370PU85_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1348-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_324583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="157" mass="18464" checksum="28EADB4D1185228B" modified="2018-11-07" version="1">MADIKPPFTEESARKKVKAAQNLWNTKDPVRVAQAYTPTCIWRNRTSFFSGTEGIIEFLTAKWKREKSYKLRKELFSFTNNRIAVQFWYEYQDADDSLRWKRCYGLEDWTFDPETGKMCKRMMSGNDVLIGPDGNGEGRWFVEGVDVEDVKIGEEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUE0</accession>
    <name>A0A370PUE0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_311685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUE0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="430" mass="49560" checksum="6498AC86E8D942C8" modified="2018-11-07" version="1">MAKSQSRPPRRKACSNCIKSKVRCTLDRPACSRCRLTGRTCDYGTTTTALEHRHFPRLQETHIGETDSLESQSVPSPSVPELSSRVLQTPPSLSYTPSPSANNTIWCPPNQQAQELPIEAFSKEKEFDFEAINLTPSSIAEDIRDRWLRPFFLPAHGRSETPKVCHPHTLQFIARIMKTYPRYMLRDRRPPPIIHHVQVRENETPRALANCYSLVRMWEQAVPGSEEIVLNTVAREMERLASEVITHLKSPDQHDYELLSSFQAYLIYSILMYFGPRGGFSDTIIITLMNMASQTARNGLSCAAELARTRPTWESWIVAATKRRAIFTLYIFSNIYNADRMLPNFVAEELRGVYAPGNKALWEAADRETWNKEYDRYLLDWQDGSLEISELWPSTEMEEPERRRRIERWVQTVDEFGMMLYSVCAHIHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUN6</accession>
    <name>A0A370PUN6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_317697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="458" mass="49767" checksum="133CF3AC55796955" modified="2018-11-07" version="1">MFGRTLTRQLSRLASRRWLSTASGSGLRINPDRLMETLHQTCEWGAAHRYGEGPTETGMARLCLTDDDAKVRHWLREEVEKLDCTVTVDQMGNMFARQRGSLGSPAPMTAMGSHLDTQPRGGRYDGILGVLAALEVLRTMKENGFRTNFDIGLVNWTNEEGARFPKSMCSSGVWAGEIPLEKAWGLTDIFNPTVTLRSELERHGFLGSVACSHDPATGYPLGAHFELHIEQGPILEEAGKSVGVVRGAQGYRWFTITVGGRDAHTGTTPLAARRDPVLAASKMIVASNAIAKRHGALASTGVMKLPRSSSTNTVASEVTFTLDIRHPQDAVVNTVQDECLQAFAEIALEDGKGVSLDWTLDTDSAAVKFDEHCITAIQDAATQLVGKDQWMPLTSGAGHDSVYTSRHCPTAMIFVPCKEGVSHHPEEYCSPADCALGTQTLLEAVVNYDRTRGELSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVC7</accession>
    <name>A0A370PVC7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_289660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="290" mass="32982" checksum="DB278F9081FE97B4" modified="2018-11-07" version="1">MESRSPTPTKITVKPSASGTMKPDLPMDHQAENDFASPTNPSSATSTASNYRRTKSIMSVDEPAVKFLYTIMKQLDLRTIDWALVASQLNISNGHAARMRYSRLKGQLENQGSSQKVARPKRAETRRAARASSSRARTTIVPVTSYPDFEPLVPIKEEVKEESYDDTMVRMADIPLAPPHAMQAGSFVTPMGYPWGYYYPHRYSMDEYNMYMPMGYAGSYQQQQQQQHEQQYLPSAMASVDWEAFKFEPEDEEKRLDEVKDEPVDKGKGVDREIKEELSEKKSEITVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVE4</accession>
    <name>A0A370PVE4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_289673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="731" mass="81118" checksum="F6CFB56BE4B1ED16" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVP5</accession>
    <name>A0A370PVP5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_228987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="420"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="652"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="709" mass="76541" checksum="45B4ED6E62CD3DDC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVR0</accession>
    <name>A0A370PVR0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_332875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="570" mass="63592" checksum="A0E2B3B193453695" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW42</accession>
    <name>A0A370PW42_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="66" mass="7692" checksum="75F234A344F82598" modified="2018-11-07" version="1">MRAAINWRTRSPWQGEQRSLVVARKSPDTNEIERRSRYKRCFSNGEDSMDETDDDAGFNGIAIDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM4</accession>
    <name>A0A370PWM4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="53222" checksum="D43B1FB3F255FBFD" modified="2018-11-07" version="1">MDPEWGDESEASTVGDEQEDTINEIVAEVIDQFLTEFSRQLGIRQPEDSSPPRSLEPKVPETEEEYREYVWSYIENKLRSYYQPGDQYVEEIVKSAAVRARSLTQKYELKAETTPKLAIMALYDFVILCDDSKSMRKDRGTRIRALEETCQRVAEIASAVHEQDVYLRFLNNAEDRHLNKLSPNEIQGQMKKIKYSGLTRLGTVLRTKIIEPLIYDPVINGLSAKPVITIVVTDGRPEGEHENCFGETILSCKQRLSELSMQPAGAVFLISRVGNDANAETFLSNLKMNEELQEMLYCCQDQLDERREVFRRAGKDGRYSSYVVELDCLIPRVVDVEREYDDVEQFIPWVFQHTDLMDWDCTQDWPEEEHLFKNLFASLVDYIEEQGHGNMISEILCKETGISNILKPSETITLPRKSWRVSKRSSHMNFIYSQSHMFADLMRNIYYRLDGVDEEAPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX06</accession>
    <name>A0A370PX06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_305980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="604" mass="69276" checksum="FF7A9B3FB099063C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX43</accession>
    <name>A0A370PX43_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_323252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="196" mass="20578" checksum="DB3C1BFA644DCD7E" modified="2018-11-07" version="1">MPSSSPNQPASTSPSSSDLESDLLQHLTSTPALEDLHATLLSSLQRLGWTERIRKLAQELLRGGRCERFDEVFEAVVASAEGRKHPVLAEANKAKQSNGNSGEEDGSGIGDLESFDVRIPSSVVEQGVRALKEVLREVVVAEDGGDILGDLENGHKEEGGSGGGGKGSKNSKDGGGDTASPMKKVKKESKSGSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXG9</accession>
    <name>A0A370PXG9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_65487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="39434" checksum="9D88CA7C9239B718" modified="2018-11-07" version="1">MTKPNLLELPVGARLVYLAEGGANVIYRILSPAEMDVDRRNDLPVTVSNSLPSSMGTLQVPSMFKGKLLRLRKNTSAGISYQEIARNFDRCIRPLFKPEELVDQELVYLPRGLVQGCNEQLQAAERNGQRPKRRQGVYLSTAEPFGLLITDMTTFSIPGTTLSELKPKWLIQSPSAPPNSRRCRTCALRDMKNQKARKKGLAEEQSFCPLDLVSDRFDNVLRAAQFVKGCKDQARLAKVLYRNGTLQRLLTHQKALQDVGLYGPPPSSRDKSLAMTLRDCTMFIRMPRDDSGRVEIRLGDLDLKTGAGGKAKYWLDLEHQLIVEDWYAGAKNNVSESECAQQSPRAHSQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXN3</accession>
    <name>A0A370PXN3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_306252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000012">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="784"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1800"/>
            <end position="1876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2340" mass="257771" checksum="BCA27CAB546AF47C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXW6</accession>
    <name>A0A370PXW6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_332315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="557" mass="60235" checksum="69A566617590623A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY31</accession>
    <name>A0A370PY31_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_69869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK47106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="61764" checksum="9AA4E4AD08E5A0AC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY43</accession>
    <name>A0A370PY43_ASPPH</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_332369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="141"/>
        </location>
    </feature>
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        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="203"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="287"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="58509" checksum="2CD0E2CF43517DEB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ19</accession>
    <name>A0A370PZ19_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_299324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="47663" checksum="D9D931F87E07C39C" modified="2018-11-07" version="1">MVTARKKQKQPKRTSTDIEEKGKGAAVYPNGEYLCQREEYHDIMEHHFMMGMLTRPHIRSCPEMVRNGFIQLALRVRGWAMTWGEDKPMYRLSDDEKRMVIASLDGFCIQDDWNSIYSSLPPGGRAEIGIVLLETMFNKFIYDKFAASTFWFMDAKIDATDHKGDDNFSKRLDYVYERFRETLPQDAAWWKSTLVSVCMLSATEWGYNKAPPTPLLHTTVERRKVLLKAYGDELLASQPFQLLLRGSLSEEEQTIREARTREVLEQAAQQFTSLQGDLFGNLVVELLPELPKFDRHSKNMDSHILHVGYKPHHGARVLIVTRPHYSYHDIIATNGWQSRPPLQITTAQVLTAPKGPKARALWAAAGDDRPIHVAQGHANTAENEEVSQEENDEEGSDGEDKPRKLRRTYLRGAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZE7</accession>
    <name>A0A370PZE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2 type zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_299457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51018" checksum="FF004C67EEBFE937" modified="2018-11-07" version="1">MSPLRTIQSRFKCRISGCTSSFQRKEHRTRHEGQHTGALARECPLCARTFSRSDSLRRHIRLDHGPDEPTRVSRACRRCRLAKIRCSGGAPCSRCSAQTRQCVYDDPQRPQQQDQQPQLSASTQPLPTSQSLEDHTLPCSPLPTVEDQDSTAHFLPYIHLYFAHFQSHWPILHRATFNASDEPPLLLQAVSVIGLWVSNKPSAREAAISLHRKQGHSILAQQEKWTRALPFQTETSNNNSTGSQATASRCPVATYQAILLYLIFSFILRSHGINHTTVNNNDNTDICTTPRSLDLTLSLSPMDQHILSLLVSTCLRNRIFYYPQMMERYHHTMQSVTCIWIGMEELKRLGLAMYRLCRLCGRENDLPGSEKDEAIVGNGRLVLRISDLQFPPPDSRHLWEAQSDRELSRLLQMEACRGGTRLDGRDEGNWISSCGRLLDGAEMEQWWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZH4</accession>
    <name>A0A370PZH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_288063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="276" mass="31271" checksum="91E4FA3845EB4E03" modified="2018-11-07" version="1">MAVQVEYLGIYDFVPSEAAAIVFAILFLITTILHYYQAFRWRVWFFIPFLIGCAFEVIGYIARAKSSTQYPDYNIGPELIQYILILVAPALLAASIYMEFGRLMIMVEGEQYSIIRRAWLTKIFVLGDVISFFAQFIGAAMLAKTTTASKGQTIMKLGVLVQIVFFGLFLVTIIIFHKRLTKYKSRACGLVPWRKHLLALYATGLLIFVRSIFRFAEFVESSDGPLTRYEWVSYVFDAVMMLATCAVLNWVHPAEIKKIIEKGVPVGGENGGYQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZJ6</accession>
    <name>A0A370PZJ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_331412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="514"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="583" mass="66030" checksum="A45B723E1D541AB3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0J2</accession>
    <name>A0A370Q0J2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_322890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0J2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="611" mass="68296" checksum="3789733C58F256DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0M6</accession>
    <name>A0A370Q0M6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0M6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="269" mass="30250" checksum="F9893C1362DC9D03" modified="2018-11-07" version="1">MSDPYPQHQQPSYPSPVPDSETPYYSPPDGVYQHAGYDYEPQQFYNQHALPNQYPAYSSQYDVSQIPRSYPTQWNPQPASSSSTNINNVNNESNPTSHYDPDRLGPGYEPPVRRGSNAEYYAQSAADMQALPPSALETEQQSRTNGNDPTTAGATGEEEGERSLGGAVLGGATGYYLGHKKDHGLLGAVGGAILGNFVSNKMKKDDSDEEVEVDDDRETEYTRYHSSHYRRSSSHGHGHHHHHHHHHHHHGHGHRSRSRSRHEEYEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0W8</accession>
    <name>A0A370Q0W8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_244230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0W8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="679"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="820"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="955" mass="106434" checksum="40700D109F4967C4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q194</accession>
    <name>A0A370Q194_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_227272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q194"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="747"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK48212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114512" checksum="62E32CF62B84211F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1C3</accession>
    <name>A0A370Q1C3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_300047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1C3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56536" checksum="10E07A186BB827A6" modified="2018-11-07" version="1">MKQRNEFGERIHGCYKGLVNASYLIRMVKSVSFRYVQGHTFEIYLTFLNRSNFILLDSIKKIIMAFAMSDRSVTGTSTPHPASAAEQLGDLLTINRDALTTLAVEVRRKQTIDTFTTASVLSCHKGSRNVIHVVEFDDQMRYIIRLPISCRPGHCTETAKRALVAKVEMMRFIQKRAHFPMPEVYDFDASPENILGTSYIVESFIPGTLVSDAWFDNSGTMTLDQKRLRILDCVAETMAKLHRFCFDGIGTLGPDAHGDLRVLPCYYSRKGVGTDVQYAEYGPYESTVDFLRERLLISPGGTEEEGPFDVGCLIMLEMMIGCMPLSTSQEEETDETFVLAVPQFDSVNIRIDEQCNVSGIIDWDGVQTMPRFLGYATFPKWIMRDMDPVERGWSLESQEDSAEQLRWYRLLYNRKMQGLLNGVGDARFVNKTHIFASILLAIDNPAARKEIVRTLVGKVYPAKLEKATRLIEDAGNGELLRQDKERLLGGFELLFSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1F6</accession>
    <name>A0A370Q1F6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_288727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1F6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="346" mass="37375" checksum="00D45C0381CDA239" modified="2018-11-07" version="1">MAEADSFLHLARPLGPVAVGTAPTTAPLNVVIQPQALFSILDHSLRRNADQERVIGTLLGTRSEDGTEVEIRSTFAVGHTETTDQVEVDMEYQKQMLALHLKANPKEVLVGWYATSSELNTFSALIQNFYSGQGDGTWPHPAVHLTVSTEAGKDIETRAYISAPVGVTAERAADSAAFIPVPYEIRYGEAEKSGLEAIAAARDAEERRANIFTDIEALERAIEDVLGMIDRVSRYVESVIDEEAPASTALGQYLLNTLALAPKVEPADIERDFNNHIQDVLVVSYLANTIRTQMELSNRLATAQLTLGGESGSGESGDKRGGQRGGKGGRGGQQRTQERSGEEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3P8</accession>
    <name>A0A370P3P8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_226245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3P8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27118" checksum="6D51EBCCE1ACEF3A" modified="2018-11-07" version="1">MFWFSSHQQQQQQQTPLLPPLPTSKSKIRRTLKAPGRPIAIRKDQITDTKTLLIVRPQGDAQSAVAYKIQDADGITLYTATGRKFSDRPCREFRDASGLPLFELHRKTSFKNNWSVTLPGSNPASPIAKGALQRSSFSAAGWGNCNFTITFDNVAAADGKQPEERTLTLEVQRHGNVLALFDIVDGDRKIAEVKESIRHNEKLALMPASRLGYRPVLDVIVTPGVDMALIATIAVIASDTVFASNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P427</accession>
    <name>A0A370P427_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_322306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P427"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="264"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="47724" checksum="D92FEE83923561D0" modified="2018-11-07" version="1">MYTLPVLIAALFLHVKFPLLPGLRDTLYGIIVLSACSAIFYPPDTRDFIRYTNAFLSTSFVIRAVELLLVQDLSHLKRLQRVSYLSSSPVYTWEPISPTLGWKRFVQVCDLIINPRAVGWSYGSPKYQPPVRKLEAASAPDGANGCVPKREDIVLVAGDDRFTFLIGKLCRALVAYFIIDSYQTAIGRNYSSVSNFVETFLTNVLGIQASPAKTEGVIRLFVLPPVHWMASYAFVDGIHAATGVFSVGVLRIISPQLAAEPWMYPPVFGAIRYMFTFSLRDIWGKMWHDLCRRPFLALSLSLVPEACPLGLKRLLIVCLSFMVSGIVHAAGTYAVSKDWYAAFMMMFFFCVLPTCVVVQQIISDQILPRVLPAKSTISRVVIWLVNAAFVAAWGYYTSPWFLNYSKLPEAIESIPMPVSFWGVVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P431</accession>
    <name>A0A370P431_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_225879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P431"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="357" mass="39479" checksum="201EB55117E603DB" modified="2018-11-07" version="1">MVGGSVWLDGRISSSSWKVRALSVKREMEMSESSWRSDRGRTKERNRGSIPGGRDRSSSCLLQSSVRVVPAVREPTLTLTGPACPVRMFIQTFKVEMVFMSAGWSNYTESLLIATLCSQDSGTHHVLDVDHAGRTEISPASYSKAELTSRLRRLPFPTCGRDTSNSKGSTYLQMPQCSSKFQSFTQLSYPTRKTPAEQEDAMLVATVGGTLEYCCGLQTDRHSMQELAVVDDCIKPSIACNHIELVLMESGNTKIMSSDCCCCRCRQGADGNGGLVWYLLAMECPAGVTASTDSAFQYTPPSRRPHSTSLSQDYPRCYQNLIYPYSERIIGAIKYSESPYTRSKYISPPQNTVYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P493</accession>
    <name>A0A370P493_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_330972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P493"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="244" mass="26095" checksum="7BAF91FCA14CDE65" modified="2018-11-07" version="1">MPLPARTASITRITNETKIQISLSLDGGILPPYEPCAHFPEPTDPAELEASKKGIIPNKAAPHATQFTPTQQITINTGIGFLDHMLHALAKHGGWSLAVRAKGDLFIDDHHTTEDTFLALGSAFTEALGARQSLARFGRGDAPLDEALSWAVIDLSSRPWAVINIGFRREKIGDLSTEMITHGLQSFAQAAGVTLHVGCTYGDNDHHRAESAFKALAVAIRTACTRRVEGEVGAGDVVSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4J3</accession>
    <name>A0A370P4J3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_109776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4J3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30715" checksum="AE3F2EA4F6291AE4" modified="2018-11-07" version="1">MHRSSNYSYQQTSSSRSSNHGTSSAFSPNANPNEDWTKISDLAERRRIQNRIAQRNYHLEKRAATASTSPERSHEGSESPKAVVHTVKSRTKQARTTKSSSDANRHTSAQRGSSYDSHSTQEDRLFSQQCTRQLSASPPPVFSYPSYSHLESYGHHSYGQAPSYHSLNNHYNDLPYGEYGTTLPSILPGPILGSGAKKHHSYADDEIVSPFSMSYASMAGIDLGPTPQHLPEHNIPMPPLSSVYSDDHSSPSTPAEPLLHYPLTPKSDPCSPNSYPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4L9</accession>
    <name>A0A370P4L9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_110363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4L9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="45682" checksum="6314DD2EA5D1A59B" modified="2018-11-07" version="1">MATAEGPARAHDRNGRRHPFSSWMKRLASLKHSTDSSANRWSNKRHAMPKYKSRSSKNNPYPLSGTAHMVADYNSDFNTSEASADSGRRSCSQSEPSLAYSGYEQQVPATSAKSTAPTISTNGDTAISEAAYSKAGTMATVGGGISSQGGGEGSTFSSPAPSVRSLTTTLTTVQSAAPSGQLYNTQNQHHSLTHTGSLHNPATQQVQFSHQFPPSPATAVPPHLAPHGHSVTYSTATANNILTDNASILTLASSSKRRRRNSLDTNASVRALAPSSVFGGSRESLPLSVLSGNVGESATSSSFNPPGVLNRPSLVGLASVERASVYSASGATPLAGSGERGSFHKTATAGDGASVISAAQSHSRHDSNAASITGTGMSSPWSGPSSNQPMTGRISRRSSGWGEINGDESDVEKLAEGREEEPEIKVEGVTDLKRELSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4U9</accession>
    <name>A0A370P4U9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_259988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4U9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="214"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="622" mass="69808" checksum="AEB5261F1CC9C1F0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P551</accession>
    <name>A0A370P551_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_107044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P551"/>
    <dbReference type="SMR" id="A0A370P551"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802198" description="Cell wall protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19301" checksum="518323CDD24B68A3" modified="2018-11-07" version="1">MNLLPLLLTLTTFLLPIATAFTSTFENCQNLNRLNQTVHRVHPLLEKFSSIHASQSQSSTTTTTTLANGTTITVTNTTSSAAIEKIEGVKALLLSSQEKIYGRLSNCSSDAVSPRNVLEKGVKRDDDDDGSCTLNDVLDQLVDTLECVLSFATGLLETILDGLFDLLKTIIEGVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R2</accession>
    <name>A0A370P5R2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_92794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R2"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="37852" checksum="B748E6AE9803DB30" modified="2018-11-07" version="1">MPSQPPLPPLLTPYVSSLPPSSLTVLSSVLGATGNWLVLRFLYAALNSSSTSDAVAGLSDTNNGRKRKVVLVSFLRGWEFWRSEAKRLGLDLARLSDKRQFAFVDGLSELFAAPPTTSSQTPISQASLRGTVPPRTVLPLRSQPGPIPARGPQPAARPVAAPPNPPTSREVGPVKRLHLSGNGNVALDALEKDIAAVINDLKSSTSGDEQEEPEVLLVLDQPDLLLAATGPSRGIGATEMGDWVMGLQQYAHATVMTVSSDSPLIHNASASAHQGATPLETEHAAFAIGSAHRAHMVMQLRNLETGAARDVSGVLRVSKGGAWGQNDSTEASSHWEEKEVLYFVQRDGGVSVFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6C1</accession>
    <name>A0A370P6C1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_258765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6C1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="613" mass="69221" checksum="F07E5E43BD4F4C21" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6S7</accession>
    <name>A0A370P6S7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_90266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6S7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="829"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="868" mass="94789" checksum="5C15C14C3618EE20" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7A7</accession>
    <name>A0A370P7A7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_339540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7A7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984816" evidence="2">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="29089" checksum="BD678A492EED3737" modified="2018-11-07" version="1">MKVFYTLLVAALTGAVTASPVANGGSYKDVQGYYHDYDDHQCTRVDRECKKWDSRECKCLDKDKHNYRRQTASITAPPTPTDTNTNANANTNANNNQNTNVNQNTNLNTNTNANTNQATTGPSSVTSAPTTSSTSTSTSTSTSSQATSTSGNANANANANTNTNTNTNTNINVADQPKGESAEAVAIPLIIGATDSGVPTTFQVVRSGTGITAGVEAASASISTPTAATGTGTHVHADNGYLRHSRGVSWLVVDGKGSFAFISFPQGQKSIGLRRTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7C4</accession>
    <name>A0A370P7C4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_297462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7C4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="116" mass="13116" checksum="8E373F8EC7F5232A" modified="2018-11-07" version="1">MLIFLGKLNYPPYATNELFAVIFSNNMQQGEKVAVILQWTRDGAGQPKANSFAQGSVDKAVITSTGEKEIEFFYGDRETTYYWYKGTQSGSNLTLSMFNNKGEEVVKKIELLATYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7X3</accession>
    <name>A0A370P7X3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_297241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7X3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15497" checksum="C84686E6BBBA3AC2" modified="2018-11-07" version="1">MASGIPGLQLHADCCPWCLSSMDVSPGTVDVLPENLNGGSGVLLSDLRVHPTGKYVYTLVRGHNVVSAFAVDEVSGRLRRIQTATINGISPKGCTFSPDGRFFYIAVSVSNEVQVWAVDANGILVPTEETAAVPRPSAITMVGMTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Y3</accession>
    <name>A0A370P7Y3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Y3"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="290" mass="31391" checksum="4022C08099778BBD" modified="2018-11-07" version="1">MSNCSQSPHPNRTRTILHAAKNGKYAVGAYNCYNTDGIMAVIRAAERMRSPAIIQLFPWTMHFQGAHFIRFVVAAAHAASVPVAVHLDHCINPADIDLALTLPFDSIMIDGSSMNEAENIAVCASTVSKAHERGMTVEVELGRIEGGEDGLPSVDLGSVLTRPGDARRFLEATQADFLAPSFGNVHGGYGLVGAEKCWDLDLLQQIQQAIPSTPLVLHGTHPVSDELFLKAIECGMSKVNVNRTVRDKYTEFVAENAGELELTTLKVQAVEVYTESVERVMKLFGSAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P805</accession>
    <name>A0A370P805_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_307580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P805"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="16"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="39906" checksum="7203830A2F3B4A65" modified="2018-11-07" version="1">MTTNVPATRKVAVCIDTHHIELEERPMPTPSGSEVVVKIQATGICATDLHLVRRTIPYLQRKVDVCGHEGVGHIVAVGPDVDTSKWHMGDRVAHRWIFDVCLNCDMCQGGNEQLCDSRKLSGKDVEGCWGEYTIVNSKYLMRIPEDISAAEAAPTLCAGTTAYRAIRTSGLTSGQWIAIVGAGGGLGHLAVQYAKANDLRVLGIDTGPSKRALCCRLGVTSYIDFMETRDLAADVSRVTGGGPHGVIVVSSSTRAYEQALTYVRKLGIIVCIGISKLRWYLRATSQANIPPAPNKMHFPIGPEYFVARGVRLTGSSTGTMEDTCEALQYVRDGRVKPIIIEAQLEEIEACLQALEKGEADGRFVVSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P885</accession>
    <name>A0A370P885_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ALDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_286416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P885"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="464" mass="50175" checksum="DCC0C03E05D059C0" modified="2018-11-07" version="1">MRVVPLWINGQAAPLVPERIYEIVNAVENKVVHHAQGADVEEAKSACDAAAAVYPSWSKTLYWERRNILLKAADLIESRAVELGRAHQSSGRRLPNSTQNLLGTIPLVYDGEIRVFVHKEAIGPVLLIPPWNSPSILGPRCMAAALAAGCTIVLKASELCPLVYRKLVDVFEAAGVPKGVINQVQVRREDAAAVTDALIAHPAIRKVEFIGSTKLGKVIGQLASKYLKPLLMELGGKSTVLVLKDADLEMAAKNFAFGVFCHNGQICFSTERIIVIREIADKFIRALKEKVATNYADDLGSAATKSFALQSQAIVQAAKNDEAEFVIGNNSLIGPNKTTLTPTILQNVKRTSELADEEAFGPSASLYLADDVDTAVDMANDRLYGLTAAVWTNDAMLAMDLSSRLQYGIIHINACTLADVPMMPVQGCKSSGWGSNNASYGINDFLETKTVTMRPAASKIQFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8R5</accession>
    <name>A0A370P8R5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8R5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="37101" checksum="29146570836619BE" modified="2018-11-07" version="1">MATILYNQLFVTPSLPPAPFPFHNRTVIITGANTGLGLAAAHHIASGPIGKLILAVRNLSAGESARAEILNAQPDCDPQTVEVWPLDLASYDSVRAFATRATTTLDRLNVLLCNAGLATFQCSKAEGHERMITVNVISTFLLAVLLVPKLRETRRLCQQMGEEGHIPVLSIVASEVHAFTKFPERNAPAEKGVGVFEALDEPERYYKTMAERYRTSKLLDVLLARELADRIGDDDIVVNCLNPGLCRSQLAREMDNVVVRIMLRLLGRTAEVGSRTLVTAAAAGRESHGQYMSNGVVCPRELSSFVTSEEGRRTQKRVWEELSDILEQIQPGIMRGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P975</accession>
    <name>A0A370P975_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_306752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P975"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="56152" checksum="93CFDFB7D1F1D626" modified="2018-11-07" version="1">MGSIAKKNVYLPIVVVDEILEYLDLETIKSLRLTDRTWSELCLGPRFKSFMRHQSTDLTPQSLESLSALSCHAILRPAVKDLTIVAAVYDFSLVQRVLRTSRCEDENSTLWIAARDCTMDEVVQAEADLAWLEEQSSKHQLKRENHIVSTLAAILNNFGRLDWVAMEAKVTHSPRPEVFRSRGDWHAIWLKATQVYHIAMSAIAKSTISLNSLTIFRNPIRSAIPSNEITTHMRTLDAAACTFASGQSIKNFSIDLSTRIDTDRERLSKRRGDIEIWELETRRSWHGLSPGTLLASLEPEVNSEDNYPGVARLLQKMPNLEALTLRLRCTVIGDVSLYHRLFEEIASKVHLPQLKRLRLLGIYATSDSLQCFLRKHPDIELLGLEKVNLVSGAWQPVFEEMRKMQSLTRVVLASISGEGRTLNLRPAEDKDDRSDPSNTDYYLCTRGVFVHRREFDARDIQKGFQFNTDNQGAPQGTHGFTSFLVFDQEHYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9G9</accession>
    <name>A0A370P9G9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_278714</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9G9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK38826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="67804" checksum="C9DB09C806FADD7D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9T6</accession>
    <name>A0A370P9T6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_329516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9T6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="22185" checksum="A1797A7D970BB2EC" modified="2018-11-07" version="1">MCKTDTVLSILCGTWNLDSEEEMQMIFYENGTGELILRHIFNAWIAAETEWKSLGPQPLDQISVSDSDTTSQTEAQVLAHFNLEITLTKRAITTRGSTDDYILNEENLINAAFLPKRYSVRLEKGSFKTAFERAAVPVRPWRQSYAYQLVFDKSPYPPLNEWKDPEEAPEPPFLPFEEWREFCSRALPKDGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Z2</accession>
    <name>A0A370P9Z2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_338718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="134" mass="14815" checksum="F33A7BD5B190843E" modified="2018-11-07" version="1">MTWVTVLTATFGAVLYALAYLASWIYGLFSVLASPLWILGHALLYVLLSPLRLLLKFEAILSYLTVAAIMGVVLGISIHYGSSVTVEAIHRWFSSRKINTAPRRRDSFHGRLLDKVKRASSPSDSNASDEDTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA33</accession>
    <name>A0A370PA33_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_58966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="60" mass="6623" checksum="77BB5134EBBFDD60" modified="2018-11-07" version="1">MHAAGYYFATKYAVCCLRCLTPELPWFLATNDPCSLGRVSLELGNGLCVCVCVWMAESMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAQ6</accession>
    <name>A0A370PAQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_329002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000006">
        <property type="entry name" value="Signal recognition particle 14kD protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="14068" checksum="15A2CA38030BFE7D" modified="2018-11-07" version="1">MPAHLGHEEFFTSLTTLLSTTSQKTRGSVYLTQKPLLDSTNTQSQPSILIRATDGNTNAPNPKTAEAKKKVSKATAASKVKISTVVSPDDLEAFYARYAEVCKAGMTGLKKRDRKKGKAKGKKEGGKVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAY5</accession>
    <name>A0A370PAY5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UROD/MetE-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38962" checksum="2309BA87C4F9868A" modified="2018-11-07" version="1">MSGESSMPSGVLLLGSIPLSSTEEVFNKIPAALPGRLFAIPDGETGIRDNYIRWQVDCFPKETIHQFLGGTDVPADHPGFTLDDIKPTQYDTVAFESYQTFLKLREQKVIPPGVRFQVSLPLPLNCVQGHTRAKFHAQLDPLYEQRMIESVQSIIQNIPAHDLALQWDVCFEVTALENERGRLTDPFFKPHFSPVMEGVLERIQRVSNINIIPAEIPLGFHLCYGDLGHKHFVEPEDLGLLVDLANNIHKRIHPRPITWVHMPVPKDRDDIAYFEPLKKLELSQHARLYLGVVHAHDEEGTRRRIQTAKSVVSDFGVATECGMGRTPAEELPSILEISRNVSSPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB49</accession>
    <name>A0A370PB49_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016654830" description="Ferritin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26608" checksum="7B42CE0C3D11B2AC" modified="2018-11-07" version="1">MRIFSALNGLLLAGAAVAQSSSSCSLQSNETQAVNYGYALSFFLDRFYSSIPVNQTFLSSSQNGSNSQYFTNFQGIQRQNRLGVRAVQQLGSKLSGWTPQNCSFTFPSASDADTFVQTALQLESTVAGAYIALAGYTQAPEASFLWARLAAEHTAHAYYIASQNQTVLFPTNSSSLVPAYSPGYVLSNGTAPGQLGSYFQGCVTAPPAPCGQTLFIGPLTATLGANVSASAAASSSASLSASATPSPSFARRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBI7</accession>
    <name>A0A370PBI7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_320568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="273" mass="29180" checksum="934E64FE09464DF5" modified="2018-11-07" version="1">MSSLVEVASEAEFPNIISSIPPSCLQVLYFHAPWAAPCAQMRAVISALASQYPATNPPSIAFLSVNAEELPDISEEYNVTAVPFVVLVRDNKILETISGSEAIQVRDAVERHAGAAAAASADGAPKTVIPPPLTAVPRENVPATATQAPATNGNAAAPALTPEQSKEALFARLAELVKAAPVMLFMKGSPSAPQCGFSRQIVGILRERSVKYGFFNILADEDVRQGLKEFADWPTFPQLWVEGELVGGLDIVKEELENDPEFLDRFSVNKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBJ5</accession>
    <name>A0A370PBJ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_278072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000089">
        <property type="entry name" value="Threonine aldolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="367" mass="39504" checksum="50E439002695DFF7" modified="2018-11-07" version="1">MASVSTASNGSRPSTWQGAGAAEFDLRSDTMTKPTPAMLEAICQTTLLDDVFGEDPVTNDLEAYVAERTQHESALLVMSGTMGNQVAIRTHLKEPPYSVLCDHRSHIICYEAGGVSSLTGATVMPVTPKNGVHLTLEDIKKHAVLSDNIHYCPTKLISLENTLDGMVMPLSEARRITEWAHQNNIKVHLDGARLWEAVVSGAGSLPDYTTLFDSVSLCFSKGLGAPIGSIIVGSNEFIKKARWFRKSIGGGVRQAGVISAAARVAVEETFGPDPNGQQGKLLGSHQRAKKVADMWTSRGGKLSHPVQTNMVWLDVEGSGLGPDDLAEIGREKGLKLGGSRIVVHYQVSEESLSRLEQVFEAAMNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBL9</accession>
    <name>A0A370PBL9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_50731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBL9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="15997" checksum="C10A849A6AD0585F" modified="2018-11-07" version="1">MQDVSTGVMWMVRRWRESKEKQRKEKKQKGTGSTVDQPRITCFSQPIRPGRSEIKSRMLHTAPASILRCQLRDGKGGKKGRTFWGSESAEAGRSTTGRQATGKNGFWYDSRGDDRSNRRAKEMRHISDSWTLFFLVPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW8</accession>
    <name>A0A370PBW8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_51608</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016713675" description="AA9 family lytic polysaccharide monooxygenase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="41482" checksum="A0701B22095A6DA7" modified="2018-11-07" version="1">MKTTTYSLLALAAASKLASAHTTVQAVWINGEDQGLGNSADGYIRSPPSNSPVTDVTSTDMTCNVNGDQAASKTLSVKAGDVVTFEWHHSDRSDSDDIIASSHKGPVQVYMAPTAKGSNGNNWVKIAEDGYHKSSDEWATDILIANKGKHNITVPDVPAGNYLFRPEIIALHEGNREGGAQFYMECVQFKVTSDGSSELPSGVSIPGVYTATDPGILFDIYNSFDSYPIPGPDVWDGSSSGSSSGSSSAAAAATTSAVAATTPATQAAVAVSSSAAAVVESTSSAAAATTEAAAPVVSQQATSAVTSQAQAPTTFATSSKSSKTACKNKTKSKSKVAASSTEAVVAPAPTSSVVPAVSASASASAGGVAKKYERCGGINHTGPTTCESGSVCKKWNPYYYQCVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCI0</accession>
    <name>A0A370PCI0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_320399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCI0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="73"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63229" checksum="3D705EE9DB4FA2A7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCW9</accession>
    <name>A0A370PCW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_46974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="477" mass="53068" checksum="035AC10E6929923B" modified="2018-11-07" version="1">MGDEASHDNHLAPAADHDVPAGVGANELREPPRGRLTPRPSFLENLASSREKQFMLGRRNSSEIDRYFHGPRDLDRHSKWPIFLRMHGSIMPKMILPLTFVAAWATVITCISKFVHNIGINDILLTVTGFVVSLALSFRSSTAYERWADGRKYWALLNQTSRNLARTIWVNTAERAGEEGKEDLLAKLTAMNLILAFAVSLKHKLRFEPDVGYDDLAGLVAHLDTFAKEAHDRQVVQPPKKTPWKSVGEYLGVSFAESNPRKLVKRSKKPLGHLPLEILNHLSAYVDRCIANNTLNVSLHQGQAITALSTLNEVLTGTERVLDTPLPAAYSISIAQIAWIYVLVLPFQLYDFLEWVTIPASVVAAYIILGLAFIGSEIENPFGQDVNDLPLDTYCRQLAVELDIITAMPPPKLDEFGTREDNFVLFPLSTSGYPEWKDRSVEEIRAALRAKVVANYPSAAMSDAATMIGSVRSKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD83</accession>
    <name>A0A370PD83_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_303682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47738" checksum="E81A444103B24042" modified="2018-11-07" version="1">MPFPFRIMNHIIPGQHIREYPQSTRGRQETPHQLAIKQYIPLDRPDPVPDNAICIIGSLGNGSPKKTYEPLWEDIYTELKHRGVPLQGIWMADTSNQGESGVLNEYIQGDRTNWYDHSRDLLLMVNQFRDEIPRPIIGVAHRMGCAQLVNLSIIHPRLLSTLILFEPVIIEASFGGPNPALAASLRQDLWPNSESAKASLSRGLRNWDPRTRERYLQYGLRKAPTALYHPSDPKVGAEAVTLRTTKHQEAWSFSTINLESEHLDRLLLPDWDSERERPYLFSRPECWSAMRDLPFLRPIVLWVFGEKSFLSLPDAQDVKMRVTGTGVGGSGGVQAGALEKAVLVDGTYALVFENVEWCAETSARWIWKWYNGRLADEKFWSEYRSRQSDHDMLRLSKEAVQVAKMPVGAKRGEACKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDF2</accession>
    <name>A0A370PDF2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_337419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDF2"/>
    <dbReference type="SMR" id="A0A370PDF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016736835" description="feruloyl esterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="9">
        <location>
            <begin position="105"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="309" mass="34083" checksum="EB2872C8F980DE4D" modified="2018-11-07" version="1">MRLLKSLLVAASAIASCNALPGALHKRDITTQQLDTFTFWVQYAAASYCEPNYAGKAGHKITCWAQNCPAVEASDATIITDFSNTTPTDTSGYLAVDHTHRAIILAFRGSYSIRSWLADFTFVYTDPNLCSGCEAELGFWSSWTNVRKAITPTLNNTVSQYPDYELVIVGHSLGAAIATLAAADIRETDGLNATLYAYASPRVANPKLAEFITNQNKGANYRFAHTDDPVPRVPLEVMGYKHISPEYWISSGNNQSVSTQDVVVFQDGDDKRGDVGFPNLLDFEAHLWYFEAWEVDACKGEGLPWKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDJ1</accession>
    <name>A0A370PDJ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_40888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="109" mass="12507" checksum="BFB4506831D6BA5F" modified="2018-11-07" version="1">MRSRTSTGRRALTWTLVPQPRKQHSFSSMRLRRLRNGDKLCDGDCRLQSWPGSSTQPWLLTLLSIGRISAVSVSLGVTTDHLIREGRDAAWVLSIAMRPWTMKRFHECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF32</accession>
    <name>A0A370PF32_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="169" mass="19432" checksum="46F054559F1248F8" modified="2018-11-07" version="1">MSAEELLANVEGGVVPVTCHEDVLRIAFIYLDEGLWTGNGVFDVVDKLHSHGLSFGEGVLRFNRSLDIFYLAQLAATIYRYISQLKDDFPSFSDFPAFYIAYHAFLHSSAWRSYYSYPFLTQRTTARFYRMPDLQDLPDSSPLCQPRHSPASLHILKIPRWAYCRVHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF81</accession>
    <name>A0A370PF81_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_267907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="57474" checksum="22781871B338DDF4" modified="2018-11-07" version="1">MDLLGCVVIAVAGYIIYQVWFHPLSSYPGPFVAKLTNLYSVVHAIRGDRHEDLYHLHQRYGPVVRVGPRRVSILDAKALEPIYGFHANVQKAKSYNIFYGVSIFNAIDRTVHARKRRVMSHAFSSQALRGMEPHILSAIRDWCAALGDQHPDKQVLSACSRPGSWSRPKNMVHWSACVVFDALGEICFGKTFNTSFSDANHFFFPLMALNLRIMNICGQMPILCSLGLERYLRRGTVANRQRQIDFSRQQLQTRLAAESTQRRDIIFYLQQARDLKTNEGYSEAELMSEVMTLLGAGNDTTNTTLTAIFYYLAHNPAILARLSAEIRAVFPTLEAIVAGPDLSQMAYLHACIDETMRVCPPVPTDLPREVLPGGLRVGEWYFPAGTVVAVPTYALHHSEDHFYRAFVYDPSRWLLCGSKGTEQGEGVSAEVLSRQRQAFAPFSMGPRACIGRNVAILELELTISRALWLYDIRLAPGTEQLGVGYQGEYKIKDHFAVGKEGPVLQFRMRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFL2</accession>
    <name>A0A370PFL2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_328106</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFL2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="106"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK40704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="500" mass="55296" checksum="92C2480D4FEF66B5" modified="2018-11-07" version="1">MSKGKLTGAAVAEHNSKDSCWVIVHGKAYDVTEFLPEHPGGQKIILKYAGKDATEEFDPIHPPDTLDKYLDSSKHLGEVDMTTVEQEEKTADPEEEARQERIKCMPSLAACYNLMDFETVARSVMKKTAWAYYSSGADDEITMRENHSAFHKIWFRPRVLVDVEHVDFSTTMLGTKVSVPFYVTATALGKLGNPEGEVVLTRAAHTHDVIQMIPTLASCSFDEIVDARQGDQVQWLQLYVNKDRNITKRIVQHAEARGCKGLFITVDAPQLGRREKDMRSKFSDVGSNVQASGGNSVDRSQGAARAISSFIDPALSWKDIPWFQSITKMPILLKGVQCVEDVLRAVEMGVQGVVLSNHGGRQLEFARSAIEVLAEVMPILRERGWENKIEIYIDGGIRRATDMLKALCLGAKGVGIGRPFLYAMSAYGQPGVERAMQLLKDEMEMNMRLIGATKIEELNPSLIDVRGLVGGHSAPVPSDTLTTGAYDPLQAPRFSEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFW3</accession>
    <name>A0A370PFW3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFW3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="174" mass="19693" checksum="50F02184478F8DEA" modified="2018-11-07" version="1">MMCIPLSDRASVTTFVICCMRQGLEERLRMPFQSRIRSSIGKYTYLGKDILTPLTLLILKYQFATASRLGMKVRSQDLNPDTSARPNQTLETHEFRTMTRDKLACLGTLYPEESVIEDHVRFSAVIAVERVSRIGKMSEPGLGIAWCGNIPAWMPPGLGKERVDSKEMNYVPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG56</accession>
    <name>A0A370PG56_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_217434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="196" mass="21607" checksum="BC41A7E7A9978EC3" modified="2018-11-07" version="1" fragment="single">DDKCIESSDEYPWSYGLRLCIVTCQESPIKISSDVRFHMTRSIDSSNGAAALGSVTRDGSSDARALETHDTVPEKDITKCSPGYRGILRCTEHCIIGVRKHYNGGMDASWVACMKWKDQEPRDSNSEGDYPKEAIHAVFRQSFYFLAKLKGMIEAGQSLSGATILDTYSEGLPPGILELPNHSNPRSPSAFLAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGC1</accession>
    <name>A0A370PGC1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_253438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016967895" evidence="3">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="50527" checksum="1054280C3F3005DD" modified="2018-11-07" version="1">MTYFTLRLAVALALSTCSSALSSQRDDSLVVPFPFDTLEDVHVAKRDSLKTVEAPLVIYGDSYWMNASIGTPAQSLSFLLDLTRSRVEPAYTLDEDYTCSDDELCSEFGFYKPTDSSTYQHLTYTQRHDAGVDYSYLDTITLGDHATDNVPLDMYLLSYISYSSLGLSSVNTSFPYILVDRGLTTSPSFSLIGDNGNTTTPSIIFGGINTSKFNGPLQAFSFADHSITNNPFVTVEADSLQLTTNTNDNSTYPIPSSTPMMLRTEELITYLPNSTVQSLYTDLNITMDGVISSSRFYGVLPCARQETESHTISLAIGNMTFSVSWDELFVPWTRDGLCKFGIQAQDSNYKTRAELGVPFLRRMYVAVDYNNQFVGVATLKDDDEDQNGGEDEIVEIGTGTALPSAVGDWPASVTAYTPAASTGTAAATLTFTTATSSGGGVVPTGLSEMGRALLVPGVLGMAVLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGG2</accession>
    <name>A0A370PGG2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_301669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGG2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="37451" checksum="9C39749F67823964" modified="2018-11-07" version="1">MAVNYAKDQPPGFSNRIERVAIVGAGGSIGHYIATELVRTGKHTVTGLTRSGSKNRLPEGVKPFYIDYDDESTLVKALQGQQFLVITMSVMAPPDTQAKLIRAAAKAGLPYVMPNAYGSDFTNDALAKETRRGDVIRKSVQEIEATNVCSWIALVCGFWYEFSMARGAECFGFDVQRKHLTLIDNGNTKINISTWDQCGRAVAALLNLKELPDGPGDTSPTVSTWKNRPLYIASFTISQRDIFESWRRVTGDKDEEWTLEYAPSHERYAQGQERLKKGDKLGYVQMLYTRQFYPNGDGNFGEKHGLANDALGLPQENLDECTRRAKEMIEGGFAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGI3</accession>
    <name>A0A370PGI3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_277211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="165"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="606" mass="66749" checksum="B19D351FEC2ED7DC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGS0</accession>
    <name>A0A370PGS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_301762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="355" mass="39405" checksum="61FF4E63A70D8BBF" modified="2018-11-07" version="1">MGPSPKGKEMIVIVSVLVGLTCLSMTLRFVARVKRRTGFGVDDCLCFVAVVLMLGMLIELILWCSIGGNGYHVSDLNTRTIELFYQIFLSSQFTYFVLTPVIKISFICFYRRLFTTKHFLRFTFGLNILIAAWSSGIFLACALQCRPLRAYWDINVKGRCFSATTYIIVNQAFNVLMDFVILAVPVPMIWRLHRSWQDKLALNAVFALGGLSLIDDEQLLFYIDLKDVTCEILCGSDNASASTGSKLTLKLDTIYDATLWTHIEPSVGLVVSCLPIIRGMFPRCTSAGQKQRTRSSFGHSSTGTTLSGGIDHECFDGRKGLRGGCAISGRACHRSESALELENIRVTTDIEVQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH60</accession>
    <name>A0A370PH60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_235806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH60"/>
    <dbReference type="SMR" id="A0A370PH60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016903253" description="feruloyl esterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="31963" checksum="10E19581A7320613" modified="2018-11-07" version="1">MFLRREFGAVAALSVLAHAAPAPAPMQRRDISSTVLDNIDLFAQYSAAAYCSSNIESTGTTLTCDVGNCPLVEAAGATTIDEFDDSSSYGDPTGFIAVDPTNELIVLSFRGSSDLSNWIADLDFGLTSVSSICDGCEMHKGFYEAWEVIADTITSKVEAAVSSYPDYTLVFTGHSYGAALAAVAATVLRNAGYTLDLYNFGQPRIGNLALADYITDQNMGSNYRVTHTDDIVPKLPPELLGYHHFSPEYWITSGNDVTVTTSDVTEVVGVDSTAGNDGTLLDSTTAHRWYTIYISECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH82</accession>
    <name>A0A370PH82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_28060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="17779" checksum="1C3A98378D5E9B28" modified="2018-11-07" version="1">MPDWRIYHPTGTFTHPSHKEELSEAITSIYTRVGLPAFYVVVLFIEMPAGTMYRAGVSCSVNGVKPFVRLTFSHIARHFPPGESPERNRFMNTIHETLKPHIADKGYNWEVNGEELEREFVHINGLRIPPTGSEDEKRWYHDNEPSPWGPYLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHE9</accession>
    <name>A0A370PHE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_28433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="17441" checksum="2E933FC28D98540F" modified="2018-11-07" version="1">MDTDESPPEFYDVYLTEQHGVRNHLAIFIETDPDAEPFCNSGRLYHVVGTILRGMDYGHRNTPDPELLPGYVMDSKRKIAVIAKDDVIRFERECAEEIPPPPAQLTLSGKPLNLAVPLYRCTDWVEDVVKLALELGIFKREGTEGKLYFGSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHI1</accession>
    <name>A0A370PHI1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_294488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHI1"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="647" mass="71678" checksum="C4D1FB411E5162DA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHQ9</accession>
    <name>A0A370PHQ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_301851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF24">
        <property type="entry name" value="TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="519" mass="56231" checksum="5FCEF7C5C0223505" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI15</accession>
    <name>A0A370PI15_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_327206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="42677" checksum="B0136A133814EF21" modified="2018-11-07" version="1">MEGLFTLLALSIVMAITSFVVGSLPLAFTLSPSQLRLISSLGMGVLVGTSLIVIIPEGVETLYSANSLSNRKELSSRSTTAVNWQHQAVPVTTVPRALEEPDSSDVQLTPRSVLSDLPSAPVTVPTIHSTQDEKLRLLGRKDDTSGDHADEDHDEDNSPHAWIGIALISGFILMYLIDKLPVFASSSKQERIPYHISLDNLGSGLRRNSSPSREGGLLDAGNIPRRSHSFATTTGLVIHAAADGIALGASSSDTGLSFIIFLAIMVHKAPASFGLTSVLLKQGLSSRTARAHLLIFSLAAPVGALMTFLFVQIMGSGSGGDDVGNRWRTGVLLLFSAGTFLYVAMHTMQENSPNSSSRESQVNGYGDHREAPSASDKSMRDLIASVVGMVLPLFLQIGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIJ4</accession>
    <name>A0A370PIJ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_23130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIJ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="21304" checksum="B1C29AE1DB3D2774" modified="2018-11-07" version="1">MSTQRYTSALESLKASNQNLDYKMSTLRSNVFRLKSDLSKLQRHVKAFHNELLTTWQADTLTRLVEVVYERQNWKLPGGVAVGDHIHLSRERQSRILATAARRIRKPILRKNFGLSVQYYSALQRYDEIVHLRSTNAFRTECTFARRLVSEKENHWGMYRFWGALFPLCYSRSVEESAEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJC9</accession>
    <name>A0A370PJC9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_276690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="507" mass="56706" checksum="2037206F2DA7B942" modified="2018-11-07" version="1">MADFVDPRMTSVKPRIRYNTIGGINGPLVFLDNVKFPRYNEIVSLTLPDGTERSGQVLEARGNRAIVQVFEGTSGIDVKKTKVEFTGHSLKLGVSEDMLGRVFDGSGRAIDKGPKVLAEDYLDINGQPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVIMTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFIDRQLHNKGVYPPINVLPSLSRLMKSAIGTGRTRKDHSEVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERTFISQSPYESRTIFESLDIAWNLLRIYPKDLLNRIPKRVLDEFYARSARKIANKDTRDNTVSEQTQGETADLIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV2</accession>
    <name>A0A370PJV2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_294135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="84"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="56215" checksum="B8B7B600B55B5CFB" modified="2018-11-07" version="1">MAQSQATKGLPTAIDLGHHINSKSRARHPSPLKDIIQFMAVDDMVSLAGGLPHPSFFPFKTVTVTASPPTAEGSPCLLELPLDGFLQYGSGTGNAQLRAWCREFTQRVHRPAYADWNVLLHPGNTNAWSKVVGLLCETDDYILCETYTYPSAQAFWIPLGIKAAPVASDAEGMRADTLAQTLRDWEDTHPGTRRPRVLYLVSVGSNPSGVTMSTKRRQDVYDVCIEYDVIIVEDDPYFFLQYPEYDSGDSVTEGPEFVGSDEFLRSLTPSMLQFDHQGRVIRLESFSKTLAPGLRLGYFVANPLFTERLLRATEVETQDPSGLSQALTLRLLQSWGIDGYLGWLQGLGVEYCRRRDWMIDAFSQHFRVVYAAEATGTLVAHLGDVPIFSFVPPTGGMFIWACFNLAQNPAFEQLRHDENVVDPEQVMADQLWRQFAEAKVLLTPGSYYHPWQGPDKVTTNARGATPSTTYFRFSFSMTTQEETERGIARMAQVIRASWKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJZ2</accession>
    <name>A0A370PJZ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_17011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJZ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="14166" checksum="B5E103F92B906330" modified="2018-11-07" version="1">MNWEGDLPSKRTFGSYLTLGVIQIYSPAPPDAARARPGAKPSGFEALSISMFEMVCTAAYWASNNALLLLRVMHTWKSVSLKGIMTETLFIAGIFRRYSVASEVLTLELQQLTRAPQRSQLSISYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK29</accession>
    <name>A0A370PK29_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_266339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="17191" checksum="23823C4CE30AF16C" modified="2018-11-07" version="1">MPQRSLSMLSTASRVRRGLDNLFGRDTEYGKCVPVDGHMDLHNLKSVEHVVRFDFEHLNDLKPYNSTISPPDLFRPILLRPMESNQLQKSYTTKRLFANIDQFIGKVSPRTRCSQISSLIHVHATLPFLWKSISHVLTARDVIGGMFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK31</accession>
    <name>A0A370PK31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase 2-nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="355" mass="37422" checksum="262663F1E835E964" modified="2018-11-07" version="1">MSRLQHLAPALSRLYPWTSSPLIVSAPMRVMSGPALAVAVSRAGGLGFINNASPNIAADLEQASSLISSSTLNATPTPTPTPHLPIGVGFLLWADDLDSAVATIQKYKPCAVWLYAPPNGQADLDNWSRGIRTASPGTQIWIQIGTLSEARSLLKSTEKPDVVVVQGAEAGGHGRAKDGLGLISLLPEVADAFAGSEIPLFAAGGIADGRGAAAALCLGASGVVMGTRFLAATETRIARGYQQEVVRAEDGAVTTIKTLLYNHLRGTFGWPEEYTPRTVINRSWVDHLAGKGFEELKVLHDEAAKEGDKAWGPEGRLATYAGASIGLVHEVKDAESIVKEVREQVLERFGSIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKD4</accession>
    <name>A0A370PKD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_314941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="296" mass="31776" checksum="8E1815DE68188265" modified="2018-11-07" version="1">MATLASSTKPQKQYTPQWVSLIAGGVAGGVEAASTYPFEYAKTRVQLLRTSKSTPSNPLRLIFTVAQQEGVGALYTGCSTLIIGTTAKAAVRFVSYDTIKNSLSDERGSLSPARGIVAGVVAGATESVLAVTPTERIKTALIDDAKNARQFRSSLHATQVLVRTHGLRELYRGLVSTTLKQSATSAVRMGTYNILKESFKAHDIPPTLFTTFCMGALAGVVTVYATQPFDTIKTRAQGVQGAGLVEAIRNIQSDYGVRGFWKGSSMRLGRLLLSGGIVFSVYEKMTYLLHPSARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKE2</accession>
    <name>A0A370PKE2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BcPKS20, polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_292826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="477"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1395"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1775"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1872"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1558"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2632" mass="284668" checksum="8FC556C41BC79AEA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKU7</accession>
    <name>A0A370PKU7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_233616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1120" mass="119126" checksum="DB40A1DFA950B7D7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL02</accession>
    <name>A0A370PL02_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL02"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="40913" checksum="CC1D72113C102FEC" modified="2018-11-07" version="1">MEQPHNLRSLFAEAKAEKSALEARPDSNTDAYRSDVNATIAKLEECQRLVGLLSLFSSNEPLEDISTTDIQYLTVEYHLADLLQRTYSSDREALLRRALGQYERFLARLDDYDVLNEKDKKLYERYTSNPSSFSLTTTNDAATRREVKINRFREEKELKQKLEYFANNQNRLQSDEEDVRKLYIAEINLYIHQSFQSLDLLSQELTMLSTIRNAAPNPADPLQDDPRRRNQASESSYSERLDPPLAELLRGGKFGPILSKEGKPMQPFTLLDRRTQLQQGVFRSGHNLPTMTIDEYLEEEKRRGNVIEGGGEKSGMKPEVDEDDMDLADEETMKARAWDEYKEANPRGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL14</accession>
    <name>A0A370PL14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="358" mass="39939" checksum="54E7B0B0DB0946C3" modified="2018-11-07" version="1">MSLSLLTAQYFQQLDPHLLTFPEDNYLLHPTTQETIYNTLFSESHAANDHPLPPPAYRTRVLKRLITKLESLLSNPEEDEINESLLEEYSTLLTLPKPSSIEQAQQLTYITYTAPPEDDPHHSSSQSKERRTILTSESRSAIITAGTTGHRTWEAALHLATYLSTAAGRAHITGKKVLELGAGTGLVSMFCARYLEPEVVVATDRELGLMRQIGDCAGRNGLAGDGDGVFKGWIWEWGRELSRGVGEDDDDTRMKEDGEVDDEKVEFDVALGADLIYDIDLVPLLVQTVKSLFEKYAVKEFLISATLRNERTFGAFLNACEESALKVERVPFESPAEEVQTGFFHSTVIPIRTYKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLG5</accession>
    <name>A0A370PLG5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_276114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11011" checksum="B388245F5A19C701" modified="2018-11-07" version="1">MSAAAKTKAQTLINENGVVVFSKSYCPYCTASKNLLNELGAKYTTLELDQLPDGADLQDALQEISNQRTVPNIFISQKHIGGNSDLQSKKGELKGLLEAAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLS7</accession>
    <name>A0A370PLS7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_326043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLS7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="443" mass="48491" checksum="2193057FB803D977" modified="2018-11-07" version="1">MDTFSSSDSPSSPGNRIVSYLQTLAKSKTELPYGLPVCVSPSHTVTSTDSLLHLASLVGPHISILQVHADIIDDWSEETVRQLTTLARKHGFLIWESGRILNSTVDVVGRQKSESREVRSGVVDLIRKKYTRGVVKPASWAGMSTAWASGAAVYNQEADILIPTLKAAAREAVADAVQTIRTEITADSFANEHSNSDQDSSQSQHLTEYAVDHSGLGLPPRKASTISLTQTITQHTEDSADYPLESPQFERHGFEFGTLSPSTIPEDLPPPPLLARGLVLCLPSRTDTSFTPDYRQSCIAAARANQDFVVGFLCGEPWHITSQRSDIFETGLSRYGDEQQQLSPYSSDDDEELPHFALFSPICQGRQPLDGSEEEEVEEEEETPLPETTIPIESLNPLAAKLFYAAGKAFKLREATSQENGIMPKSDTTKSCQILHIPIVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMQ4</accession>
    <name>A0A370PMQ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_314675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMQ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="33551" checksum="7903E2FA3BBCE836" modified="2018-11-07" version="1">MTSTVISDAYTILAGLPASYQQRPFPSWKQLRNEVEAIYTQLEQNNWSGNQWLALTDMSQAAVNKLKEDHDLLAGISVRFMWIGTTGLIKVAAGVPHHFTTSELFRYIDCQCLQMGVPRTQYTWGNAVTLPDTLSTKGKQPDCCLFPPSRLPLGGLEEWPTLVIETGVSESLAKLRRDATWWFQNSSGDTRIVLLLSIDSGSRTLRIEKWQLVPSGRSVTRLFIEQLRQQHSLIPPLAQQPASMQTAFCVQEVVITPEAVMGQPLVIPFRALLDRHPTGDERDIVIDNEGFREISRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW8</accession>
    <name>A0A370PMW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_292713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="82"/>
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    </feature>
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            <begin position="127"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43545.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1484" mass="161043" checksum="AC82B1CFAB5DFF5A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNF4</accession>
    <name>A0A370PNF4_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <end position="18"/>
        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11177" checksum="3178697931E1562E" modified="2018-11-07" version="1">MSTSSWLLLLNLLPGGRIYPGFKVNGKWISLGSRASLLAAGVGSEIPSEQKSTGFTPDIPHIHTLYCLCLSLVIRYYYYLYCFRKGGEGGVSSGIPEARFNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP23</accession>
    <name>A0A370PP23_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">M752DRAFT_249338</name>
    </gene>
    <organism evidence="9 10">
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        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK43926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
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        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="85"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="273" mass="30289" checksum="AB5683F80A0317DF" modified="2018-11-07" version="1">MRLSSIIPFTDLSSPRSRLASSTTYLVAHSLVPVRFIRTTAPTGPYHLATSLRSSHRNIFPLQRIYSPPSLPSSHSPRLRLLSTMSSATSFYDFEPVDKKGSPFPLIDLKGKVVLVVNTASKCGFTPQFQGLEKLYQDIKAKHPEDFTIIGFPCNQFGSQDPGSDDEIQSFCQINYGVTFPVLGKSDVNGDKAAPVWTWMKEQQPGLLGLKRIKWNFEKFLISADGKVVGRWASLTKPESLEEPILKEIEKAKKEGSLASLKKEEAKAEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPR0</accession>
    <name>A0A370PPR0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U2 snRNP component prp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_232594</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="246"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="780"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1232" mass="136691" checksum="F2AFE76084F80F78" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQK4</accession>
    <name>A0A370PQK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_274544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQK4"/>
    <dbReference type="SMR" id="A0A370PQK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="614" mass="66884" checksum="3DBFC9C48858D40A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQP3</accession>
    <name>A0A370PQP3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_313326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQP3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016770463" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65629" checksum="4049C09DB4213ACF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRA6</accession>
    <name>A0A370PRA6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_290802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="32313" checksum="033D64F497E4C2E5" modified="2018-11-07" version="1">MSYTVRKIGQANTLEHRVYIEKDGQPVSPFHDIPLYANEQQTILNMVVEIPRWTNAKQEISKEEFLNPIKQDVKKGKLRYVRNCFPHKGYLWNYGAFPQTWEDPNTVHPETKAKGDNDPLDVCEIGELVGYPGQVKQVKVLGVMALLDEEETDWKVIVIDVNDPLAPKLNDVEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNKKYALDVIRECADAWEKLISGKSPRGEISVATTQVEGAERADAAQVAAIPKGENLPPAPIDGSVDKWFFISGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRR7</accession>
    <name>A0A370PRR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_247478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="250" mass="27093" checksum="66229252A3A77DFC" modified="2018-11-07" version="1">MTDTADAPQTNKAFVPLENNPEVMTHLVRQLGLSPTLGFTDVWSIDSPDLLAFIPRPSYALLLVFPVSAAYEATRRIEDAPLPDYNGSGPNESVMWFKQTIRNACGLIGLLHAVSNGTPRKHITPGSDLDNLLKEAEGLGPIQRADLLYESKALESAHADAAKLGDTDAPAAEDSVDLHFVAFVKGEDGTLWELDGRRKGPLVRGVLEEGEDALSERALQLGVRRFLEVEKGSGDGDLRFSLVSLGEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRU6</accession>
    <name>A0A370PRU6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_128761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRU6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36050" checksum="73F77CAC4EED6371" modified="2018-11-07" version="1">MTQSNNHHRRTPSGSNVPKLRNSRPALHRRGTSWVNHSISKLGSGQVTKQLELEDDRQPEMAASFLNFCAMCEKQITVPDNSLLYCSESCRRKDSHKPLSASFSSNSSMSSSTTPPASPPMSPRMIVAPMTPTKGAARSSISRIPSEWNDSKTDQDPSEWKPVIPMGSGASSLASSEAWNYLSQFHRDDTMMPVRRPRFDHRSSTSLSALWSATGPVPPLMHTPSTAASSVSSNGSDYMSYVHDSAYRPLPPRHKPQISGCSSATKGLDLVVPHVHVSVEDVPAVNISNDGSIFPASSALWDENPIEKTPTLKTALGSPNSDIPARSLEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTA9</accession>
    <name>A0A370PTA9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_324374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000129">
        <property type="entry name" value="Benzoate 4-monooxygenase cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="569" mass="63395" checksum="08CD4C017297F296" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTG5</accession>
    <name>A0A370PTG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_290333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="326" mass="36554" checksum="92EC574DFC6D53AC" modified="2018-11-07" version="1">MASAGLICQGEGGRRYRLVRPLGAPVRGKGCNVWLGLDDSKPDAEYIMKRPPADQNEESWSGALSAFKHELEMQRLFAKDPMIRKLVDYVPESEPSGPMMVLEAFTDSLWDARNVRPFTTKEIKWIMKGVLLGIFTVHMKGLVYTDLKMENVALGGFDPSKPNENVRDLIVRLADCGSISKPSTREITSLTYRSPEVYFGKPWSSSTDVWSWGIILAQLLQAQVDFRSPGMYDSIQTGTLAEKGNVIRDQLAIDFDLSSVPFYAEDEQCAQFLPTPQPEEAYMWANTMVEKGVSGEDIQFLVEVLNPDPNARLTVREILESGYLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTJ9</accession>
    <name>A0A370PTJ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_274528</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTJ9"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="557" mass="64568" checksum="82C01D5E567391AD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTM9</accession>
    <name>A0A370PTM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_333363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="415" mass="45449" checksum="AE2523628892526C" modified="2018-11-07" version="1">MSSPTVLIIGCGIAGPVLAILLKRKGYNPIVFEKVQALGDAGASLMIQPNGMKILNLVTPTHPLPIITPLQSLWHGTASGKTLGHSTLPSTYVDRYTQPASGIKRSVLNLHLKTTLREHNIPLYEGYQLKNIHELPHQITASFTNGKSITGTFLIGCDGIKSSTRRILLSKKAGISEGPPTFTGLIQVAGISKIPASLSEKDISLSNWYGEGVHVVAYPISAEEISWAATIPDTEGEESTWRAATAGTEVEDLRQKLREKLLGFEDCVLEMVNTAERIISYGLFDRREVPVNQWFSGRVVLVGDAAHPTSPHLGQGANQALEDCYHLSRMLPDLRVDGVVWDEVDQGLSGIFEEFAQLRQPRTSALVKEARRLGEQRVVVGGPERCRQRDASIAYAWRNEEAVARGLDGLFKEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTR9</accession>
    <name>A0A370PTR9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_281795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="576" mass="65101" checksum="9973A4D08531B4D1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTZ7</accession>
    <name>A0A370PTZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="242" mass="26356" checksum="1BA40F349428C1A6" modified="2018-11-07" version="1">MPNPTLVFCAGAWYSPVAFGPLIEKLPDYTCRTVAFPSIEQATEVKDLQPDITAVRSVVEEECDAGNDVAIVLHSWSGLPVSSALDGLSKTERQEAGKPGGVVKLIYLSAFIPDVGESLIGAFGGVAPDWYVRDVENGTVTPDDPFKLFFHDVPDGQKWAETLRPHAWATKNSPATSAAYLRIPSAYLLCEDDRAIPLFAQEGMVEKARAKGATFETDKVKTGHTPWLVVPDQVVEFVKRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU78</accession>
    <name>A0A370PU78_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_317608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU78"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="574" mass="63421" checksum="18622933198B7115" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUP1</accession>
    <name>A0A370PUP1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_290707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="500" mass="57248" checksum="AFD0DDA872D7BFC1" modified="2018-11-07" version="1">MMDFYKFATFIVCFFIGWYALTSVLAWYRLREFPTPSWLAHFSYLWLGRLTYSGKQYWVHRELQRKYGPLVRIGPNEIMTDDPDIIRSMSSTRSTFTRGEWYIAGRFNPHYDILFTILGNDAHKKARARVFAGYSGRETGIAVEHGMDRQVTRLIDLIRQKYAVPGEDAPLLNIVDISSYFTMDVITELAFGQEFGYLQAEKDRYGFFHEVHSLWPQMSTVADVPWIRRIIFSKPFLKLLGPRTTDSHGFGALMRVAHEHVKQKFSTLDNSKGDMMESFIRHGLTQEECEAEGLFTIIAGTESTAGTIRSILIHTLSSPVVYSKLKNEIRDAVQKGSISSPISNKEVKDLPYLQAVIKESIRMRPPLLGLFPKVVPAGGVEYHGQFLPGGTHICMNTSSLLHSKSLFGNDPSVFRPERFMEASEDTCSERRKNLELAFSHGQNQCLGKTIAIMELSKVTFEMFRNFDFQIVSPWRLNHQVQSYGVFLESNMKSRVSQSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUR3</accession>
    <name>A0A370PUR3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_317682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUR3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="53313" checksum="B1AFFCE9B8051739" modified="2018-11-07" version="1">MTICNASLQVLSHRQDRHRSPAVIFTRRLRPTSALSMSPMFPAFSESFDLNNTQLLLITGVCILSFAYANLIVVPCSNIFGRRLTFLVFLSISFASYIWEALASSYTSFIVARVVNGAGAAACMTMSLTIIHDKLALSSSGRLTDPWSTRFGWRSFFWLSMAMTCFNFITILLCSPETKYHRDHAPNPLRHTPHASLTPKAMESPTDISPTVDSKETYSTQPLPPKPGTGSPSSAQFKIWRIPDMRWKAFLLRDLLTPFRICLYPIIFWAAVTVSGVANFVLFWNLTESSVLGAPPYNFNASNVGYSNFAFLIGCMVGLVTAGPLSDWVAVKATQRNRGIYEAEMRLLALIPPAGILLLSVLVGAFAILSSWPWPVLLIFGYGLSGLVVSAMSSIAVAYAMDSYKPVSGEIMAVVTIVRNTCGFSMSYWVPSLAERRLGYFLPAMVQLALTFGPLVLGVPMYFFGKRLRMWTRNLSVHLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV39</accession>
    <name>A0A370PV39_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="476" mass="52207" checksum="9D631EE363DB7149" modified="2018-11-07" version="1">MPRFDDADFAVDAAPAPGARSPRDARGSAAGSLPIPNDAGNTVEIPATRSSISDAAQYMHNLSFAPSSRDRRGSRNSFGTSLPIPRSPRVSRLSSVVTADVSRDILASQVQDMSKEKVAAAKNMAFAFDIDGVLAHGNEAIPEAKEALAMLNGDNELGIKIPYILLTNGGGKTEDERCAQLTEVLGCPISTDQFIQSHTPMQALAEYYETVLVCGGEGQKIRKVAENYGFKNVIHPKDILAWDQTISPWGCFHEEDRLQAKPRDFSKIKFDAILVFADSRDYATDMQLIMDLLLAEDGKLLTRAKDPVASRIPVYFSQGDLVFPTDHKGPPRLTQGLFRISIEAQYKALTGVDLERVVYGKPERATYTYADEVMKAWMEQIHNENRLPENIYMVGDNPASDICGGNMHGWNTCLVRTGVFQGKDNDDNNPANFGVFPNVLEAVKAAVRKELGQDFKFKWNPKVNPVLHGDGASAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVB4</accession>
    <name>A0A370PVB4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_97656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12223" checksum="FD1F4D0721446841" modified="2018-11-07" version="1">MSFFRTAEDIRVEDGHILIARVANEEGEMVESTLDLNSCIGNEEGRFLWGGNDFAGSAEDISFAIEGEDNVPVLRARLQNSEGEAFDADVNLGEHVTNNNGTLEYQEESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK1</accession>
    <name>A0A370PWK1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_273576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="247"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="57225" checksum="B8CED4A0681DC468" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWT0</accession>
    <name>A0A370PWT0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_317365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="520" mass="59272" checksum="ECFC162224EC3378" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX04</accession>
    <name>A0A370PX04_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_333015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="35062" checksum="02436B488CAE37BD" modified="2018-11-07" version="1">MDIEPTLPIPISYIGGSYFLFSIDAVTYVRREYHICGVLSGTLPQIPQQNVFLGLPLKLMPEEARLLVEKGVACIVDEVKVQKDGMRALMEEDRKKYLRELESQGQHAMRLQNDRKEQQREKALKKIEEKKAAKAKKSAEKQQEQQPAPLNNEAAAKDPVIDLFANDQEGSGEMSRRSSTATAAPFGTVMGVTPATSYPPLPYEWSAEQQLPLPDVPSSYPLFAHLHSEGYFLSPGLRFGCQYLAYPGDPLRFHSHFLSVSADWDEELDLMSIVAGGRLGTGVKKGFLIGGAEKKIEGSDAGDPSSVRTFSIEWGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXD6</accession>
    <name>A0A370PXD6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="172" mass="18685" checksum="33F42F4826090D2F" modified="2018-11-07" version="1">MNMTSPLSQSTDRPLIQKERRTASGSTPLPTVPEAASVASTPELQQGEFNPADGAKPSSPFYRHATPSLAIDRLKKAAKATTTRYSPLDPEDPPTLHRQPVESTSHRESKLWAQKKRRCGWMQRLSRKQRMAVKATIAVVTVGTMVAIALGITAAVGGAVWKSDTQQVVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXH3</accession>
    <name>A0A370PXH3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">M752DRAFT_272672</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="61523" checksum="217CFE6491475C9F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXH7</accession>
    <name>A0A370PXH7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_272673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="433" mass="49555" checksum="1EA914BE1E8F641D" modified="2018-11-07" version="1">MAGLFKNVFGGSQPSNPAKVDDDFADFVEAPEPSPASLVAGSSSIPAVNTQGVTPVPYTKWYRVWERTSPRDFMQEATVMPIILLIILFHFWGTRKNRRKARDWAQAHTSALQSEFAVVGFDGPSSSNSEGQPAPESLLKERSAQEFASYATGRQNVAFVDVAIKLPKRYNPVTFWTETVLGFLFESWTPPTESYEATAYTFDGKEKDVVPLPANDRSSLKVNNSTYDGFIWAVVHKNYMRKFRQDRYDASITFTRDNNKLPNWVTVMTESAEITDALLTNELAQAIEKAGNDFKYLIVTDQPVDKPMKIEETTPRKRIELSVTLPSNAEGYTTTLPLFTQFLRFADRLVGAAHFRPEVMRKVRGTREEEIKKLRRADEEEKAEERRLAAEKVKKEDRERLLRGMSAEEQKKYLEREQQKEHRRMMKKSTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY21</accession>
    <name>A0A370PY21_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
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        </source>
    </evidence>
    <sequence length="334" mass="36580" checksum="AF871D45E471D99C" modified="2018-11-07" version="1">MTIIRELGYAQSLSLEPDKLGSQWVLMNPAPEDSYRGAFTSDTIKPETIGGTWYPSPPSKSLPPFIDIDNDQEQEVDDEKSLVILSFHGSAFLWLTGRPDDSGFTADLLNEKLGTGTRSLWVQYRLAGGNNPTPYPGPMQDAVTSYLYLVRELNISPSRIVLVGDSSGATMAMALLRHLASFQQESGHELAELPPPRACLLFSPSVEYSFEGDSQAMNAHRNLRTDYCEGKMAAWGARAFAPPESVRLDDPYLSPALHPFATPVPIFAQVGGAEVLCDSVRGFADAMGAVPGNIVEYLEVPGLPHDIYMMGHILGWQEEQEEMIEAAARFVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZV0</accession>
    <name>A0A370PZV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_288199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="739" mass="79907" checksum="3A7C976D405697D6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q080</accession>
    <name>A0A370Q080_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_322819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q080"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31525" checksum="55A9BA1BE6AE76A6" modified="2018-11-07" version="1">MRLFVIPISTRQALIYARPLRRGPSQKPSIHDRVIQKAAETWAKWEEADKGWKKHLVSWGNRVQQRIPYQEWGLKSIPSLAAVRRLDESYGTKKVDVLFPGNAIRPEKLQKMLQAIATERQDLHRRRMWLSLLATPLTAPVGLIPLIPNVPFFYLVYRAWSHGRALNGSKHLEFLLEKDILNPISYPGLEELYAKRVSYALENTGVDKPISEMVEDVEKSDDRLLLRMTDAKKLASILEAPDLALEAERAIIQVEEKLKAEAKKDGEDGASEKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Q5</accession>
    <name>A0A370Q0Q5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Q5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="47265" checksum="8555E77D2A79C77B" modified="2018-11-07" version="1">MLPTRGITLRGHKSARPQALACQICQLSAPSAPLHQSVRSSPLTRNARPGQLRPQRSPRNSWTPTTYAIIPRRFDSTKPGHPTPADFEEAVDQIAHECTELRGTDSVPSNDKVVKLLQQCQRIAEAMVHPEQDTGKNQQPDEISSLLDLEEGKNAATRKQKQPTTTTLPRKTPEQIIDHLCKSVHNLLTDEKVFISPEALTCYTKIHAMLKRPDHFPEIFHLYANKPVPEENSSPVRYHKAKPKSINSAVPVELADMALDVAIAQRNLSLVLAIIDTTFSTPAFRRAKVFKRAAVPLGGIAAAPAACYTLASWASTLQNTMDPSTATGIAFAAGLAYVGGVTSVGVLAITTANDQMERVTWQPGVPLRHRWAREEERAAFDKVALAWGFKDIYMRGEEEGEEWESLREFIGMRGMILDRTELMPGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Y8</accession>
    <name>A0A370Q0Y8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_323015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Y8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="749"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="497"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="761"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="864" mass="95841" checksum="AABE787AD0172BE7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q120</accession>
    <name>A0A370Q120_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase lambda</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_227167</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-X family.</text>
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    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370Q120"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
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    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="131"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="230"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="18">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK48140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="708" mass="80007" checksum="0B52683F36E1B574" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1B6</accession>
    <name>A0A370Q1B6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_207457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1B6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="416"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="969" mass="106544" checksum="2C4ECFE5012ED7C4" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Z1</accession>
    <name>A0A370P3Z1_ASPPH</name>
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        <submittedName>
            <fullName evidence="8">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_340403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Z1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="674" mass="74782" checksum="0CEE83FAAC818441" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4A0</accession>
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        <submittedName>
            <fullName evidence="2">Lysine decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_340268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4A0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="257" mass="27723" checksum="6D41AC1DC688AD96" modified="2018-11-07" version="1">MGFENGTKPAVVCVFCGSVSGTNPRHMEAARQLAHEFHKNNIHLVYGGGTAGLMGTIARELVKLSGPQAVHGVIPRALVKVEPGYDNATEHPTDTDSTTGIQQARSGKDAERIIPAATTNGTTTKAKESMFKESEYGTTTIVADMHARKRLMATKVQEGGPGSGFVALAGGFGTIEEVMEMTTWNQLGIHGAGVVVVNVDGYWDGVLAWVRKAVQEGYIGEENGRILVEVNDIKDVWPRLKGYRVSNGRMRLNWGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4R3</accession>
    <name>A0A370P4R3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_259914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4R3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="219"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="51571" checksum="3B5D253FB2405C66" modified="2018-11-07" version="1">MAPDKKDKKRKAAAAAAADSPAKKTKKVEAKPAESPKDAPKSILKKANQKESAAKTDGASKAKANGQPARQIKPRKRAADFLSDNDNSDSEAEVAETKVQKEEKPTTKKSKKEDGTAAPATKSKPAKTNTKAKKAEPVPEESEEEDESAASDASQSEDEEDDRTAALIKGFESSGDEDESGDEGFNPDQPVPKIPDSKKAKRKILKKQKENAGQAEEPGTVYVGRIPHGFYEHQMRAYFSQFGDITRLRLSRNRITGRSKHYAFIEFASTSVAKIVAATMDNYLMYGHILKCKYVSPEQLHPEVWKGANRRFKRTPWNRIEKKRLDKGKTREQWTERIEREQKRRLAKAEKLKAIMGYDLDIPQLKSVDEVPVQEAKAIEASEPAAEEPVKAIEAAPVEESKAEKPAEDTPKKTNKKTKKAAQSPAVQETPKSAEKSTPKKTTEEAASPAAQKAKKVQKKTKAKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4R6</accession>
    <name>A0A370P4R6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_322083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4R6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="47943" checksum="2365C62044F84989" modified="2018-11-07" version="1">MLRKVWSSSYRSSVSFQILSDLHLEVNQQYSSYEIPACAEYLILAGDIGRLTDYDDYRNFLQKQTDRFRSVFLLLGNHEFYNETFDTGIEMAKQLEQDPAFDGRLIVLHQKRYDVPDWSVDDHNARHDSDYSWLTKEIHSIHEENRTVAKDSKRRSILVVTHHAPSLQGTSNPRHAQSPWSVAFGTNILSEVPDGVKVWVFGHTHYNTDFKEKGVRVVSNQRGYVLPGSDPKADSGFDVRKQLGVCNCCVVAYPRLWGRIQPRAESRGWEQQPPVSKVHHAESPIVIIPSSTPHLDHISGRARAPVRFSHVLDCHGDGQQFQPDYQLMVFYRKHTTTMTSRGSNPVSRLAEAAKEKVAPSTSSKAKDPTENWTPEEMFETTLDKNGNPVPDAISYIDGPKMTQKRQGPDEGDVFDAANQDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4S4</accession>
    <name>A0A370P4S4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_108342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4S4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="489" mass="56430" checksum="AA19BBA39667C464" modified="2018-11-07" version="1">MPPPLPSHHRGMTANPVRPSRYRPGKAIAEEPSSSEEEDEDEQEAKKEAERQRQQERRRLEQQRRQAPKASSFPAGAAKIARVVKDVKIEEEEADEDEEGFVTEEEEEEEEEAKPAKAAAPVAGDRVAAPARTATVKEISEEEEEESSEEESSSEDEAPRRVLLRPTFIKKDKRNNAPGQTQNGQAASGTVVDTSAETEARRIQRQEKADALIREQLEKDAIARSEANRAWDDDELEVGEEGAIDDTDGKDPEAEYAAWKLRELKRIKREREAIEAAEKEREEVERRRNLTAEERDREDREYLAKQEEEKEANRGQAGYMQRYFHKGAFFSEDMQREGLAQRNIMGAKFADDVSRETLPQYMQIRDMTKLGKKGRTRYRDLKSEDTGRFGEGFQNRSRHRDGGAPIGITDERFMPDRDRDERPKGPTGANASAVRERRRSRSRSYSPRRERRDRSADRYRPDTSSRRKRSPSPYEDREKRRRLSVSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4W6</accession>
    <name>A0A370P4W6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_280087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4W6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="225" mass="25771" checksum="A123193FDB809A87" modified="2018-11-07" version="1">MSGLTIHHLRLSQSERITWLCEELEIPYTLKCYNRQPPTLMAPDEYRQLHWSGTAPIIEDNGVVLGETMAIIEYILAKYGKGRLVLTPDHPKYADYVFWLHRAQGSTMPSFMGMLFSRMRGTPSEEDAVYKMSESRVKATCEEMDQHLAKNIYLAGEEFTAADCVSVFHLTTLRLFIPYSLDEYPHIVRYLERIGQRPAYKRAMEKGDPDLVPLLAPEAPAKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4X4</accession>
    <name>A0A370P4X4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_330853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4X4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="77"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="59521" checksum="0BE94909F192D464" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Z6</accession>
    <name>A0A370P4Z6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_310647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Z6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016992820" evidence="2">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="34570" checksum="CE2D7D7AB810DB0B" modified="2018-11-07" version="1">MRRRCLWIIQAIVLLGLLSAFYYTHIQSQALSQQDSVPTDPLEVAIPQTVHQLFISTPGTRGSSFNPDRHSTSWLQSGWKVEYWRESSCLELAHELDDTGSYAATFQALPVPILKSDFCRYLILFGRGGIYNDLDVHLLQPLPWPVMGPVKDGDEEPPSVIVGLEGDAATTGLPRSPQFVQWTMASVPGHPIFRDVLQSIVDRTGHYVSTQTAEAEADIDVMSWTGPSVWTDAVLGYLHSDDEQIQQLRDLHEIVRMRDVVILPRRSFAVLQGEDQSAPDVLVKHYFSGSWKACAREWLRWLWPGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P529</accession>
    <name>A0A370P529_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enhancer of mRNA-decapping protein 3</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">M752DRAFT_322008</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 29">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 27" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DFDF" evidence="25">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="24">
        <location>
            <begin position="443"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="26">
        <location>
            <begin position="750"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="334"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1193"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1252"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1257"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RDK36972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1291" mass="140567" checksum="37295E1AFD85AE81" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P544</accession>
    <name>A0A370P544_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_279957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P544"/>
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    </dbReference>
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        <property type="entry name" value="DUF4604"/>
    </dbReference>
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        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="18229" checksum="D23D1587E3171418" modified="2018-11-07" version="1">MSFKSKDLAYEAKQPAFLQRLKNQYGDTSGRLERPIARPRKPRDDNDDDAPTYVDEESNEIISKAEYEALVRGEDNKDTEDSHKDTKEPATGEEGKANTQAEASVSKQNVAEIGGPRKRKQAKVVGEDNPSEETEKVEKKESGTRKPKQKKKIKLSFDDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5N5</accession>
    <name>A0A370P5N5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_259294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5N5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="650" mass="72111" checksum="711888C35C0A671E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P616</accession>
    <name>A0A370P616_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_259109</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <location>
            <begin position="1224"/>
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            <begin position="1"/>
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        <location>
            <begin position="1187"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK37319.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1415" mass="162992" checksum="7336BE26318C36EE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P689</accession>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">M752DRAFT_241589</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
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            <end position="74"/>
        </location>
    </feature>
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        <location>
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            <end position="573"/>
        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64784" checksum="3F658786FCC8534E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P696</accession>
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        <name evidence="1" type="ORF">M752DRAFT_330425</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Henrissat B."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="21578" checksum="6941E2E743147460" modified="2018-11-07" version="1">MTHRFPYDEKEHAASKQTIHDALTVMHQNDIPFQWVEEDGSSLLGCYASLSYNPAFVGQFFEMAKTLYAPGTVKPRNRELAILGLSSVLDVPYVDYCHRKIGSKCGLSHEQFEDALAGKVPADLSAEEAMAYRLGRILTDLKTPLDDATWKEAVSVMGKSELVGIAHTVAGYRWVSLLDQINGDTKRWINKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P712</accession>
    <name>A0A370P712_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_286865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P712"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="61490" checksum="93F90E5C78E934CC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7B6</accession>
    <name>A0A370P7B6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_279089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7B6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000213">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="879" mass="97408" checksum="9E67336652780B9A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7E9</accession>
    <name>A0A370P7E9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_81237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7E9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="38883" checksum="A60A4F0077EA8E13" modified="2018-11-07" version="1">MPGRGIALLSLDGGGVRGLSSLHILKHLMERIKDEKGLAEEPKPCEYFDMIGGTSTGGLIAIMLGHLQMTVNECIRAYLALTQRVFTPIRSRSVSLGFSKHLGDVVSRFDSAALEEVVKRVIRDALLDPDALFYDEDRASKCKVFVCALQAEIATPVLLTNYKSKRSDSDRRESVKIWQAARATSAASGFFDAQEIEMSAGYVETYTDGATGYNNPVRQLWTEAREVLLPQGERLEDHLDAIVSIGTGTPELKAFGTNLKDIATTLVRIATDTDNTANHFQREYKELDRDGLYCRLSVANGLQHIGLEDYKQANNIMAATKAYLDHPDTLSKLTKCLERMSQHECEVDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7G8</accession>
    <name>A0A370P7G8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_241177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7G8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="419"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="529" mass="57482" checksum="914D93EA605EBCA0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M8</accession>
    <name>A0A370P7M8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_308056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="109"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="64762" checksum="02DFE2A735416BEF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Q9</accession>
    <name>A0A370P7Q9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_279170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Q9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="45415" checksum="55FE0660350F9BAB" modified="2018-11-07" version="1">MSEPKNQPVEEPTIPPEEGVKGWLTVAGSFCALFSSFGFLNAIGVFQTTYQQTSLKDYDASDISWIFAVQLALMWAPGPLWGRIIDTYGPIPVLWPCSILCVLGLCMTSLAHEYYQIFLAQGLCFGIGAGGVFTSAMICVGQWFVRRRGLATGIAVSGSSLGGVIFPIFLDRVINDIGFYGAVRYTALFVGIMLAIACLLIRSRLPRKEWNGKAAWVDLTLLKDTAFGLYTAGAFFIMWGLWAPFDYISSMAENAGFSSTLALYLISIINAASIFGRLIPPQLADVFGHFNVLTLCCFGTGVSMLCLWLPFNYHPSHAGIIVFSAVYGFVSGAVVSLMMPCVAKVGDLQTLGQRFGTFQLIMSVSCLTGLPIMGAILEKQNYTDYSGLQLFGACCGILGSVLIGAATFLLRKMRNTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P920</accession>
    <name>A0A370P920_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_239894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P920"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="88"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41284" checksum="89EB64FE77BC4A6B" modified="2018-11-07" version="1">MAILTDTNTPARLAAKGAQGVYKEHLPISYDKDAEEGRKGYPAAKYPHYLPTWDPAQKFPPLEPFEHHDPGLDADPSYSELLPPGVQVTHLTPTIGTEIRGIQLSQLSAAGKDQLARYVAERKVVAFRAQDFASLPIDKAVDFARYFGPLHIHPTSGSPEGFPEVHLVHRAAGDRSAQAYLQTRTTSVAWHSDVSYEAQPPGTTFLYILEKPEAGGDTLFSDTVQAYRRLSPAIQERLHGLEVVHSGVEQANTSLSRGGILRRDPVVSTHPIVRTHPVTGEKALFVNPQSGREVVGLKQEESSMLLKFLYDHIASGADFQVRVRWEENSVVVWDNRVTQHTALIDWSDGQRRHIARLAPLAEKPYETPFAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P971</accession>
    <name>A0A370P971_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_76168</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P971"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000084">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="428"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="721"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="898"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK38544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114789" checksum="7A34D382856C1E6F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P996</accession>
    <name>A0A370P996_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P996"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016728351" evidence="1">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="327" mass="34800" checksum="EE0F2A8AD60E285A" modified="2018-11-07" version="1">MKLIHLFLTITATTAATVNSHLSQSRGSISALDFGHRNPSPELFTETHNIAGRADASEEAHEVSSWIGSDSESDDPKDLARGLIDNAFDALIKACSLLPFHGHNAALILGKVRDNIHRDISAYPRAHLVERKAGRQSISAIGGIDENSKLGETLVQIVKLECECVSVTGYLGTHLVRALGDIALKATEGLAGGGIEDSLDGLRNQFCNKMTAVAEELFAPEANCGTDASTTADDIDIGNIGENENSTIEDVLGSLSTDGCRCLSSSLYIAIHLLRAYFEVKLDILAAILGGSLHPLANLLDDLKDLLHQALFAAGEIIRPDNVCHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9B3</accession>
    <name>A0A370P9B3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_329382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9B3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52016" checksum="CB9C7FD124D294B4" modified="2018-11-07" version="1">MSWTEVSPNRYERPFDSIETFYRAVAAAGAPLNKEHYLITCTLQLSPLPPATAVEQAWKALRHVYPQLAAEPEPDSNGSDRFVYKAITSTTQLDSWAKETFHVDIDRTANDLYEQLTPSPRVHLYYLPSTSEVVFRTPHWRIDGIGLHHMQSAFLQLLADGTVHPIDGTEPSRLCPAVDQAIADSDLPKAIPLDEATATASSNKELQPCLTQTENGNLMLPTLPNVLPSTPKRILRHIDSATTARLLDACSAHKITITAATHAALALTGLQFALHPEKKPDYVGFNPLDLRRYLPEPWNGSAAAVSLYHTGLPFRIPLYPAQVEKREEFIRLAQEFTSLYKRNLAKEAPQNLFDFLPTYVGRVMQVLGAAPPDPLLAPAHPELSSMGRVNQLLKTEVEGKEWTVKVEEWWVAIEVINRLLLTQVWTFNKELVLSVHWNEAFYERSFVEEIGKLYILINQLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9I1</accession>
    <name>A0A370P9I1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_256499</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9I1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="280"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK38840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="727" mass="78005" checksum="ED1C8FFF687F15EC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9L2</accession>
    <name>A0A370P9L2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_239416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9L2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="573"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="671" mass="75965" checksum="A94A010046EA4053" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAY8</accession>
    <name>A0A370PAY8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_55083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016927618" evidence="2">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="80" mass="9221" checksum="298EDFB14FCD04AD" modified="2018-11-07" version="1">MAWHIRAHETKQINLLTLTFLILFRNSIWRSGNFNSGDSGRHALFFVAAKGTMMQKRWNGFTGLLACLLAYVFPMQDRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB35</accession>
    <name>A0A370PB35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_56319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016563082" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9059" checksum="C4BF74C80FCA4BE7" modified="2018-11-07" version="1">MTWFCVVSFVVAARRLCFSTSERRMNGGPLFKCFLASPPLYQTHHREGCMTRRHRDDRNTGGGGLCRRGGAVESIVSPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBU5</accession>
    <name>A0A370PBU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_51399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="222"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="366" mass="40139" checksum="191AA2EBE8A64873" modified="2018-11-07" version="1">MTSTVNMGEAPPVKEHLLIAYGRDLPQWLIDETQAKFPEAELSILQLPNFAPIPAEIARKTTLLVTFSNLPAPEDASKIKIIHSLSSGLDHLLSHPIVKETSIPLTSSSGIHGPPIAEWTIMNWLVASRRFVYTHENQQKHNWAKNIDFMNTIHDQVGRKVGILGYGSIGRQIGRVASALGMQVHAYTASPRPTPSSRKDNGYIVPGTGDRDGTIPVSWHHGTDKASIHEFLSLGLDHLVIALPLTPQTTRMLGTEEFEILSRGVSAERPRPYLTNISRGKVLDQDALIEALKGGVLGGAALDVADPEPLPENSPLWEAPNVQISPHVSSAGREYIPRSLDIMRENVGRLERGEELLNGFKRGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBZ9</accession>
    <name>A0A370PBZ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_278407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBZ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="168"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="319"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="485"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="700"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="883" mass="98253" checksum="7A6E1911E7916D1C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC54</accession>
    <name>A0A370PC54_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier protein PET8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12746" checksum="2153866B97627B3D" modified="2018-11-07" version="1">MSFLTPIRATTLRLSRPAYAYTSAAALHTSIPRPGLKESDHNREDLGSIYEAEKHDQLKSTKEGKAKWKQEIASDSEASVKADRGEVDSDDKDFGAMQERTKGLPNRDGPVNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD02</accession>
    <name>A0A370PD02_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">STE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_47812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD02"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="618"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="698" mass="77183" checksum="43466DF4FF1EDBF2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDC0</accession>
    <name>A0A370PDC0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_219208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="58689" checksum="6FCBEA821C6409DC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ4</accession>
    <name>A0A370PDZ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_320302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="212" mass="23888" checksum="CA663C0227218C5C" modified="2018-11-07" version="1">MASTDSKPKPERLPVTVSKPTPYTFDLGHLLANDPNPLEISRSEPLDVSLKATARDGTQSLLNQLLTTCPITSSQQGVLLTLPSPSTVLPRFKPLPTPKPPTKWELFARKKGIGKYSSRPGAALADKERRKKLVYDEEKGEWVPRWGYKGKNKSDDEWLVEVNEKDWKKEEEAAAKGSSIRGLSRAERKDRIRRNERKMRANERKNRKSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEB0</accession>
    <name>A0A370PEB0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_254244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEB0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="51555" checksum="DF0E805C481822D6" modified="2018-11-07" version="1">MGHPEATETPGQCITNASEGLLQLDEKEDPRQWPKARKWVCTVIVAVMTGVIAFCSSIYTAGTSLITATYGCSRTVATLGVTTFLLGFASGPLIFAPLSEVYGRNHIFRVTLGLFVLFQIGCALAPNISSLIIFRFFAGFFGSPSVTNSGGSITDLWPQSERSVPLALFSAGSFLGPVFAPVAGGFISEYLSWRWNFWVVLIVSGVVYAACVLFLPETYAPKLLRDKARRQGIVQTGPSLNSQLMTSLTRPWLMLFAEPILFLLSLYMAFIYGILYLDFTAYPIVYEQSRDWTPGIAGLSFLGMGTGMGIATIASPYVNKIHATYVTKLGPEPEARLPHIIILAWLIPASLFWFGWTAMPPIHWIVGIVSGAPFGFSLILLFLAITSYLTDCYGPYGASALAANAVFRSVFGAVFPLFGPYLYDGLGVPWGSSLLGFFALAFAPLPWVFYHFGPRIRLRSKYHMMMKSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEK6</accession>
    <name>A0A370PEK6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_284845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEK6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="67"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="48216" checksum="20DF684268499A6D" modified="2018-11-07" version="1">MSQAGISRLPYFSLRTVTSQGLPLRQFPTSGYVTLDPADKIEEETLPLYKPENYYPVSIGEVFGSRYQVVSKLGYGTSSTIWLSRDLQEGGYYTLKLCAKGQSSDREITVSEHLKQSVNEIRKRMLRIVLDSFDVVGPQGSVFICLIYQPLGMSFTEFQNLLPTGKFPKELIQRSIQLVLIALSSMHESNVVHTGMAIKLGEKSNGWNQCKLMIIDLSPNNILQGVQDISILSRMEEDEIERPIARKVLSNRNIYYSRPMPLCTGLPVVCDLGEARIGKERYNDDIMPGIYRAPEVILGMEWDYKVDIWSIGNVVWDLAEGHHLFFAKRNGKLSDEQHLAEMVSLMGPPPLKFLTRSNWTGSIRIPEQSFGLRELQLSGEDKVPFLKFLRRIFRWLPEERPTAEELAYDDFLMQPFMETRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFK2</accession>
    <name>A0A370PFK2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_277073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="44685" checksum="16FD3E5D117AD754" modified="2018-11-07" version="1">MFHSSKPYSAVTVQIEVLTSEQYEVEDSSGIVDLIEAIRIQASGPTEASRALRKKLKYGNLHRQLRALTILDFLIQNTGDRFLREFADEPLLERLRIAATDPVSDPLVKEKCKQLFGQWAASYKNTPGMERVTGLYRQLPKRKQPATQAKAKVLRDAGQSEEPSMGHTVSVSAGNGPATVLSGPKHKHTSSKSSLSSFRKEKKEKKTLSRSFSLDKEKPEMLQTLASASVASTNLLNALKLVNRETQRVSEDAEVLNRFETCKTLRRQILRYIQHVESEEFLGSLIHANEELVTALMAFEVLDKSVDYDSDSDQDVLETGWTPDRDDLPDSFAGLVVNPPKPPRPPRPLSISVPSSSRKVYSDSESETEDDDDEDNPFGDRNAIHTPGIEKHEPTWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFU4</accession>
    <name>A0A370PFU4_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_236144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59864" checksum="62B0D001A63764C3" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFX7</accession>
    <name>A0A370PFX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10429" checksum="614C73FEBEFB9609" modified="2018-11-07" version="1">MMRQRQDRREKSLYSKLCDADVCLGIRIRESDQVTTFLCDSTVFWSGLSSQLETHYPRPNQITSKDFDFNPTTDEEDSTAAQEFKAARTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG44</accession>
    <name>A0A370PG44_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_302962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="603" mass="66598" checksum="0C7E2606934CB2FA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG90</accession>
    <name>A0A370PG90_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_327896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF6">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="164" mass="18267" checksum="930BFDEE2A4E67F8" modified="2018-11-07" version="1">MPETKTEIHPIIYHRQTITSLPRESFGDPPHGHLTWRTLLSSPQTPTSDMCAGLAVCPPQGGHLCRHRHTQAEIYYITSGSGHVFIDGKEYEVSAGAVLFIPGDAEHGVVNRGEEPLEWFYVFPTGSFGDVFYRFEEGVKTKDEGQGVEEKGKGEREGRVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ6</accession>
    <name>A0A370PGJ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">M752DRAFT_217103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ6"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000261">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023554027" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023554026" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="239"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="993"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120066" checksum="E8877FEE3B3A500E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH16</accession>
    <name>A0A370PH16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_319675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative DNA repair protein Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="488"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="615"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="945" mass="105678" checksum="1882414E6CD2E0DB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH81</accession>
    <name>A0A370PH81_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_267065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30798" checksum="6B9519A8C0F4EECF" modified="2018-11-07" version="1">MASTQCELYMYTPSLALAIIGVILFSALTTIHLYRMIESKAWFGIFFVLGGLAELIGHTARSFSTQDVCDRGAYGVQSVALLMGPTLIMFSVNLTQSEFVNVLDAEQFCLLPLAWQRGVYPAMNAILMVIQLVGGCMTISSSSETVATGTKLAIALFVVQTIFWGFTMAENICMSYRLGRHPTTASSCVLANWKTWNQLIPLAGSIIATGRNIMRLTMAGGIKFLVDYEWPSYAFDGYQMVVVLGAWGIWYLPGKCRELSTRVRYTNLTRLERVVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHG4</accession>
    <name>A0A370PHG4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_216912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="193"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="329" mass="35701" checksum="DC69BDC15BEFEE4D" modified="2018-11-07" version="1">MTSSPSVLVFGVGSVGAIYLHQLQQAGCNVTAVCRSNYDVVAHHGFTLRSPRFGTVTYRPDHTVRSVHDCPRDNGYDYVLVTTKAFPGRTPSLADQLRPVLENRPNTAIVLAQNGIDIEKDIAEAFPSNPVISGVVYLPTVQTEAGVIDHAEPLDLLELGTYPARAPEGHRRAAERFVELMIKGGGDAVLFEDIQEARWAKLLLNAAWNPICALSLCTDGGFLLTSEPFARDLAWGIMMEIVALARAVGIAGVDEEAAKKRFALAERRAKEGTGREMSMLQDVKMGRPFEVEAIVGNAVRLGRTCGVSMPRLETVYALAKGRLDVLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI67</accession>
    <name>A0A370PI67_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI67"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="34241" checksum="54A1AB04C68440E6" modified="2018-11-07" version="1">MDDAHPKLHLYSLPNEVLGQILSSFSTRSLISWATVSHRFYALVLRILHYRLLIGAPLHEYKLILECFHPNSKLTEPHVFCTYLDTDGLDWLSGRGGSLYENPDTTQQLGKLSSVYSRFRPEVVVEERFSGTRLVPLRDDEQESDRDNLVVTRPIILKDSEDFSQLCMVVNIVKVMPGTNLLLSAHTVEDGVIRVFRDWLRDEEKRFRDIVPDGTGPSQMLWVDQSKGVGIKVRVKAKPLMNQNVPILVHRDDDEFTSYELLIEELHIRAVRLLLTLEKSQEEQQNYYKAVVITPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PID6</accession>
    <name>A0A370PID6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_235162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PID6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="63709" checksum="BAE3F7DAB0D57473" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ16</accession>
    <name>A0A370PJ16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_216019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="644" mass="70503" checksum="14D999951E66CA06" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ71</accession>
    <name>A0A370PJ71_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02246">
        <property type="entry name" value="SgcJ/EcaC family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20386" checksum="20036FB48BEB91AC" modified="2018-11-07" version="1">MRIFNETQGTCNLIDWRHQTVIRKNSAFKPFPDTPGIGNSSVVPSTDTEEISTLLHAYGEALKSRNVDEAVALYTEDGVIMPPHFSASTGTEALRDSYTRIFATIQLVINFQIEEIVIMSPEWAFARTTAEGTKTILATQESESHANQELFILRRNNGKWLIARYAFSSMKPFVQNGIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ75</accession>
    <name>A0A370PJ75_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_293379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="29"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="393" mass="44412" checksum="8F4BD52B199941DB" modified="2018-11-07" version="1">MTSFEERVNLLRHSSENGRKPLPRVTLGAINRDGSLHYAKAFGEESIDSTDTDAVHWVASCTKLVTTIAVMQCVERGLLDLDGDVANVLPEWASPHILTGFDDNDNPIFRAATKAITLRRMLTHSSGMGYFFMDPLMTRYHELQGSPPVVQTLRQYQFLLFEPGERWMYSPGIDWAGVAVERVTSMKLGDYLQRHVFDVVSVKDATFHLEQREDLRARKVKAWTRTDQRLEEEKNPIFLDPIAEDVGGGGLYTTVSEMLKICQGILTAQLLRPETLKEMFQPHLESVEGLEKPEDYSLPSRNAIWNAIPCDTPVDFGIGGLLNRSRLPQGREAYSLSWSGKPNCYWWIDIKKGVAGIYLSQLIPTGDQSAIELLTEFERWVCSRIENLDCAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJC3</accession>
    <name>A0A370PJC3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_300449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJC3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="261" mass="28516" checksum="C467425406C4D050" modified="2018-11-07" version="1">MNEIFAADLAAYLILSPIVVYIFITHRWTGFLAWYSLIMSCSARVIGGALGVRDSSSMAANIIQSVGITPLILCVDGLVHEARTYRFPHASRRLNWCVVIGTSVTMVVAISLSIKACLDIFENKAQSDDYSLWKAGSSLTVVVWLFQIGWSVYSLQFHDKGIQGPGYQGGTVLLQGALVALAFIGVRVIYALVAVCTESKDLSPVYGLMSVRVVLMFLPELFATVTMMVVGVRTRHLRELKDETDYGKLDVVKPTSVGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJK1</accession>
    <name>A0A370PJK1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_293490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="37145" checksum="36E684822EB428AB" modified="2018-11-07" version="1">MSDLRSLGHNGPLVNSIGLGTMSIAGAYGQQNTPEEKLAFLDHAHSIGQRFWDTADIYFDSEAIIGQWFKRSGRRDDIFLATKFGLSYDASMNQSIRSDPEYVRMACERSLEKLGVEAIDLYYCHRADGVTPIEKTVEAMAQLKREGKIRYLGLSEVSAATLRRAHAVHPISALQIEYSPFCLDIESPQSDVLRTCRELGIAVVAYSPMGRGLLTGQFKSRSDLGEQDFRCMIPRYSEGLDRLLKIVERFGVIGEAHGSTPSQVALAWLLAQGLDVIPIPGTRSIKYLEENAAAVNLRLSDEEVAEIRDLVQKANFVGDRYPTIMPIFPDTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJR0</accession>
    <name>A0A370PJR0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyubiquitin containing 7 ubiquitin monomers</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_215530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="88" mass="9462" checksum="DAF445D49A3EA5E8" modified="2018-11-07" version="1" fragment="single">RGEATIFIRTLTGKTISIPEISIERLTVDTMKQIIAGKVGMEPGEMRLIFGSKQIEDGRTLGEDYGVGNGSTLHLVQRLEGGVGMASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV7</accession>
    <name>A0A370PJV7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF73">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="34937" checksum="1531E4CA35FE26A4" modified="2018-11-07" version="1">MSLNLSMRCSTVLPNKATLTEKNLPDQSGKVFLVTGASGGLGRLLTNILYQHNGKVYLAARSETKTKEAIEEIKAAHPSSKGELLFLNLQLDDLTTIKRAANEFLAKEDRLDVLWNNAGVMIPPAGSQTKQGYELQYGVNNIGHFLLTHFLRPALETAAKSAPKNSVRVIWVSSSAADSAPNPAIDLTNMDYHREEGAWVKYCRSKAASVVHSAEFARRTKGTGIISLALNPGNFVTNLQQNMSKMELMMFKLIASEPINGAYTELFAGLSDTITEEENGGWVSPFGKVEKVRKDLVDSTLGEKFWDWSLEQVKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK90</accession>
    <name>A0A370PK90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_18919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653981" description="DUF7732 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="3">
        <location>
            <begin position="117"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="269" mass="27487" checksum="D54C5CFD8D95291A" modified="2018-11-07" version="1">MKILSVATALALLFITLVTALSIPPAARDASLSADSSSLLDLVKRRGGGGGGGRSGGGSGGRSGSGGSSSSSSSSSSGRTGNSGSSGSSSRTSSSSNVGGTSRSGSGTRPTYGGGYYYAGGATAPYTSGAKSRLGVTPYLLPAAIVPLYFPGLWLYGAYVYPYSYHYHYMNDTSHKNESLPVNCICQQYLECGCDENSNSTYYESLFNGTQPRNTSVAKVVDVNGTESIYINGTLANGTTAADSAATHFGVHGSGYWIMVAVVVGIVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKH2</accession>
    <name>A0A370PKH2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_292853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKH2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="340" mass="36974" checksum="B4CF39EF3FD50ED7" modified="2018-11-07" version="1">MPRAIWTKILSDVSIKRSSQTLAILASNAYIYGGELRPREPVDSAVYRLSFDASTSSNRSLIQTPPSATHPQPRVGSASTALAGKLYIFSGRGGIAMAPIEEFGSFWVFDPTQNTWSQLPPANSNSQHPAGRSYHTLTNNGTDTIYLHGGCPSSGRLRDLWAFNIHSRQWLELPPAPGPERGGASIAYADQRIYRMNGFDGTREQGGAVDAYDVRTNEWTSLTYAADGVSGPSPRSVGCLLVTTIAGKQSLVTMFGEHDPSNLGHQGAGKMLADVWAFDLQSQRWAQVDVAEPHRPPARGWFDADVIGPEVHANPGSIIVHGGLAESNERLDDMWRLDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKK4</accession>
    <name>A0A370PKK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_250611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="252" mass="27991" checksum="0AC9746A0D6D6C79" modified="2018-11-07" version="1">MTRAKTSKLKILMIHGYTETGEFFRSEVLDLEKALMEAFPVAPAPGYHPDYPDGVELVYPDGTWRLKPTDWARYIPGTDPGFGWFYKVDDDDEFPGLLDGLQKLGDIMRSQGPFAGVIGFSQGGFLTGLITSMLEPGRKSVFEKVEVESGGIPFPKSFDGVDPIKFSISCCGFAALNLRYKAFYLPKISGPMLHVNGQFDDIVYDKRSRTLIDATTGTEEQKVLIHPGGHSVPTSRLYTDAMVMFIKKKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL98</accession>
    <name>A0A370PL98_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_319039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL98"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="353"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="54548" checksum="7DAA7A03D35FF9A3" modified="2018-11-07" version="1">MVLQTRPKPNSSYASNRLTRQSGPSQSLLSTFRNNNAKDERPKPVKPEPATDDEPISSSEEDDAVNEDDSEPETRTRVSGPSLDEKLAKSRSETTPRAPRQQRGSNTKNSTPTTGRKRTSREMVDDDADEGKDEGFFASFRELDNGNKRRKSRGYQSRKSFVNSSQSPAGSVRTPRASKDESKSMRNGSKKKGKEFKVPRDIEDEASPARASSPKTEFKQPPPMPEPNDMISSSSHATSSALDAAVFDDDDSSVGTPLSTASSSFMDELSRYGEAALLDEPAVCPWCKAPVDPGDLLRFRAQPKQRMREQRQFCDSHKQSSAEQEWREKGYPEIDWDTFDERIARHFADLETIMVPESASFYRNSLDTALKTGQAKNFRLSLDGDGLEKISCGYYGTRGAGKMLQAITARYGRKLRRLAADDQIVKMAGPVGYAQAVLVPELAVRLVKEDMGVNEETARQILRETIDLGEKVNFALNDEVPVPEESDAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLG0</accession>
    <name>A0A370PLG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_335758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="171" mass="19065" checksum="2DB363DB54546270" modified="2018-11-07" version="1">MADEGASPRELVVEACRRDQPHLIESVLEGMEGKSNEEVAEFFNSVTDSMGNHALHICATYGSYDVMDALFDIQYFECDPLTRLDKDTPLHTAVRYANEKDAELGEAMIKMMCEAGCDPRVRNKHGQKPAELVYNNQEIKSTLQQAEYIMAEGLREDADNGSVHDSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLK3</accession>
    <name>A0A370PLK3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_335794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLK3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="240" mass="27099" checksum="25870E0A0D2A0687" modified="2018-11-07" version="1">MGDIVLAFDIYGTLLSFEAVTHELERFLNDETRARSVAQTWRRYQLEYTFRLNSMGRYHTFLEVTRNSLLHALDDTGTSLRDEEIEHLMATYNRLTPFPDVEDALNQLSAFPQVTSVIFSNGTRGMISNCVESSTVLSQHKALFRDVVSVDEVKQYKPAPAVYNYLAKCVGRNQSEMKDIWLVSGNPFDIAGARNVGMNAIWVDRAETSWADKALPDVKPTAIVHHLGGIVEVIKQQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT8</accession>
    <name>A0A370PLT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_249757</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLT8"/>
    <dbReference type="SMR" id="A0A370PLT8"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="38808" checksum="3870E4E7A4C236FF" modified="2018-11-07" version="1">MPAYNIVVFAGDHCGPEVTAEAIKVLRVIEKSRDDITLNLQDHLLGGASIDATGNPLTDEALAAAKNADAVLLGAIGGPKWGTGAVRPEQGLLKLRKEMGTFGNLRPCNFAAPSLVEHSPLKASVCEGVDFNIIRELTGGIYFGDRKEDDGSGYAMDTEPYSRAEIERITRLAAHLALQHNPPLPVWSLDKANVLATSRLWRKTVTEIMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNGIIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKGRVNGIYEPIHGSAPDIAGKGIVNPVAAILSVAMMMQYSFGRFDEARAIEAAVRNVLESGVRTGDIGGKATTSEVGDAVAAELEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLX1</accession>
    <name>A0A370PLX1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_153697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="57" mass="6401" checksum="497C6E2ED6A11A49" modified="2018-11-07" version="1">MIRPSIVPAKYVTFVAVSHPSVHSIYYTPSHSHYLYSHPNSILPPPTPSITNPYLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP4</accession>
    <name>A0A370PMP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_283167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="591" mass="65515" checksum="498C92D113A64F48" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN45</accession>
    <name>A0A370PN45_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Kexin kexB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_250452</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN45"/>
    <dbReference type="SMR" id="A0A370PN45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984834" evidence="17">
        <location>
            <begin position="20"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="490"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="651"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="789"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="844" mass="92449" checksum="8AD4D8405C99A76E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNC0</accession>
    <name>A0A370PNC0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_212686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60670" checksum="502449907143F023" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNH9</accession>
    <name>A0A370PNH9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_291915</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNH9"/>
    <dbReference type="SMR" id="A0A370PNH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="45503" checksum="A45A370D79BA2854" modified="2018-11-07" version="1">MADGIDRRADDRMEFNTSKEVTVAPTFEDMHLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTVVRESQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNIGEDIRKLDYGQHVVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRVLVKRDELTLEGIKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTSDDVRILRDIELYYSTQIDEMPMNVADLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP42</accession>
    <name>A0A370PP42_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_325842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="404" mass="46081" checksum="0AB27D06CF097A2D" modified="2018-11-07" version="1">MHSSSTIKGRRSHRKSRSGCQQCKLRKVKCGEEKPACSNCKRHGVHCSFALSNRMAESTLLGDQSSFSSQTSTPQSDYRPSNPSSPSGGASQQQLAAPGPELAIADLELLHHYSTSTAYTFSLHPVIQTLWRIEVPQIAFTAPYTLRAILAVSALHLAVLRPEKQEYYISQASFHHDASLKLATPEIANITHDNCTPLFLFSALSSFICCAKPLKLGNFLLWEDHEIANWLMLIRGTGTIVDFAEESLKAGPLRTLFSVHRQRDAHSEVPKPPTQHQFLEDFRRFVIDEVTDVHEKQIYRDAIFHLGTCFTICYEKGCRLETSDVFMWLLRVPHDFLGFLKEYRPLSMVIVGYFCVLLHHLEWIWCMKGWGTHILSQIYNQLREPVYRAWLQWPMEQIGILPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPM6</accession>
    <name>A0A370PPM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_292299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16849" checksum="864A9831909AC09D" modified="2018-11-07" version="1">MTTWCNAIQLAAAAGCTVVATVPGKEFDYVRGLGASQVIDKYSTRAKEELLEILKKPEQTNLLGAIDTEETDISTAICKAVVGNRPVASASASRVPDANVVKDSEICHKIFKEFLPKALSEKSYVVAPSPVYPPKISHLLATVEDAQKKVVTPVHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPV1</accession>
    <name>A0A370PPV1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_248170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="363"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="592"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="702" mass="78879" checksum="846E1873E3F7CDFC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPW7</accession>
    <name>A0A370PPW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_136766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with missfolded ER lumenal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000025">
        <property type="entry name" value="Protein OS-9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016580411" description="Endoplasmic reticulum lectin" evidence="12">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="13">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="507" mass="57574" checksum="D8CC6131E0FDE6E8" modified="2018-11-07" version="1">MPRRNQVVNILLGLACASSTAWANKKAFNIHDDLLAYPQFEVLFPDDYVLESHARELLRERRDSSSTFADTQEKSAQVYLGRSTHDNDQAKPRDGDDGFSYEEMLLGEQRFLCQIPHVDVDDRTNSTGHPHEADEQKELARAMDRGLELLREMEGKCMYYISGWWSYSFCYKNQIKQFHALPSGSGIPNYPPMEDHTTHSFILGKFPQGDGDEDEVEGAADQKKPVTDVAELQTKGGSRYLVQRLDGGTKCDLTGRDRKIEVQFHCHPQSTDRIGWIKELTTCSYLMVIYTPRLCNDVAFLPPQQDEVHGIECREIISPEQVSDWEALREYQLAQRLVESAVMEELPVVGDIQVGAQKLVGSEGKEIEKGRVAWAGEEIIEVVAKRENGEVQQLSREDLKKHDLDPEKLETLKKRLEEWAKGKDWTLEVISVNGERQLRGLVDDDEEEEDNGEGSQEEMVTDAAPSKETTEAEAAGQEPQPQHPEEQQPLETDEAEEVSKKRVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ70</accession>
    <name>A0A370PQ70_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_138545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ70"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="113" mass="12671" checksum="40CB0A7C87BBA109" modified="2018-11-07" version="1">MSDSGGWCTILMCTGIDASVLKACLFVVSTLHISLPMEFASRCGHRLLDTRSSRSLAFPREAGRCPSYSRYHFRMPGVFKEWLRRSRQRVCLRNISPGIQPVQIGVLPLPVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQC4</accession>
    <name>A0A370PQC4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_248453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="29012" checksum="02CF118254429B48" modified="2018-11-07" version="1">MSDCCLKGFRWNGTPRGQEVILAGINCYRTGTESNVAILLIHDLFGWTFTNTRILADHLAEEVGATVFVPDFFGGEALPLDILLDETRWNELDLPGFLSRNTKLIREPEIFACATALRIEHEYTSLGAIGFCFGGWAVFRLGAKDVRLVDCISTAHPTFLEPEEIRQVDVPVQIMAPEHDPQFTQELKALSNEVLPMLGVPYDYQYFPSLTHGFATRGNLNDREEMLGAERAKDAAVLWFRHWLHKQRKTELIMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQN2</accession>
    <name>A0A370PQN2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_140768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="73" mass="8296" checksum="0AFBB0A1A622894E" modified="2018-11-07" version="1">MLTLLNRVELEGSDAGDSRHKCSFYQGTIDEQRKAFGWAGGVFRRVETLRKPVLDWWKRIGAVASKAGWADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR95</accession>
    <name>A0A370PR95_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase complex component Pdx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_333640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR95"/>
    <dbReference type="SMR" id="A0A370PR95"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="31025" checksum="478C8533A5F2E63C" modified="2018-11-07" version="1">MASTFSVCRLPAALARRQSRVLSTSKRLNSTSAPQTQNPAYPLYPSVTQLLHEKGIPESEVSKIPASGPKGRLLKGDVLAYLGAIPAEYPSEQAARLAKLAHLDLSNIKIAAPVKPAEPAPAVEEKPVARPPPTTSVAVSISLAAVLSVQKKIKETLGTTVPLSTFLARATDLANDDLPRSSRETPSADELFDEILGAQPIKFTRGEYIPELNAEEARPVQKKQKVEDDLIDFLAGKVSKKAAATAKSVVEPAANVFSLTVPVEEEKRAKVFLDRVKTLLTVEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRL6</accession>
    <name>A0A370PRL6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF6">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G07550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32774" checksum="3D61829354ECB9C6" modified="2018-11-07" version="1">MQSYPSEDIQPVPAVRTTNRGHLQFAEDKGGLWSSGNSTNVSLSVNQPVKGGGLYSNLARHFQAEIDTRYADIVLIVCGFVSGLVDGLSFNAWGSFSSMQTGNTLFIALGASSQPRYPAYLWAKSLIALCTFITSNVIFIQVARRLSPRRRSTLILSFATQTICLLAAAILVEAKVVSPKPEDPRAPIQWMQILPITLLAFQAGGQICASRILAYDEIPTVVLTTLLCDLLVDPDLLAKKNAKRNRRIGAFLALFLGAMTAGGLSKVATMASSLWFAFGLKFTITLSWIVWRAEGGSKAGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSE1</accession>
    <name>A0A370PSE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_333957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="224" mass="24604" checksum="5FEACFD172E11031" modified="2018-11-07" version="1">MEWPTSSFPTPQEDTTHPDRLPIGQLLLPRSSAVSGSQLVSSVLANSPYGAFTSVAAGLPRSIEPHVWTINPTEGLSSDRNIPPQGGVAQTAQAPFAYREIPAESLDLLYASTSSGQPRRHWTDTKADTNPTWVAPNSATSRRQHPAPERIPSVLCSDHSPPTFECNWLGCSSSTRFSTVGDLVRHLKSIHISPDAYSCPVCGKTSGRKDHLRDHRRRRHRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUF8</accession>
    <name>A0A370PUF8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_311934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52463" checksum="6513C3CB283D2B44" modified="2018-11-07" version="1">MADHTYVEHLTPLDLPMPRTYIRVLLVFPTASPTTELSQELQCGLEKLAKQVPWIAGNVFLTTSTDQKASLEIRYHADKTPRLQDKGQIAASYASLSSQDMPMKSIPLDVWPALPSLLGNIPSETGDPVFAASFFRFADQGVGLCICLHHNAVDVTGFSEVVRLWAENVVQQNQTHPSYGLQGTGDRLVQLSKALAPDLRELSSLSSERLLAVHPEYSTQSPVLPEKFAPCTSKTFKIPIHWINVLKELLQKSAQRQLATNVILCALLWTSITRVRAQRNPDLRCQTSRLVTAVNGRSRIPANLQPMPGDQQYLGNVVLYALANCSCANLATADEDPVRSLAKICDRISESQSPATIDSRFIAETYRLVDFMEDYRSLFAGWDLFGSRDFTITSWAGLDLYGVDFGPLLGKPEFVRLPCMEADGVAIVLPRRRNVCDERLEVMVMLRCDDMESLERDSMWQTLVGGGKSCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV0</accession>
    <name>A0A370PUV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_262316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001491">
        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="57652" checksum="29623AEEEC812088" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV7</accession>
    <name>A0A370PUV7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_332619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="35787" checksum="7EB891F13C691C8B" modified="2018-11-07" version="1">MHDHDVSSQSKSERGEYIALNEDESTEDLESPVPRRRGILSVSFFTNPLVYAPLAIVFAGAIVFFWMTRTGNQYKYTDCGVTPDEARARGCVFEPMQRAWIPPECYFPEPGEDYDTFQDRQWYMDPKMTIDADIEKLEAGEVSVAYTRYWHDEHCTYLLRKLALAVSMGKKMINSKALDIEHSNHCALAIAERLASSYNVSFVETDRSFTESHLGFEWCLPLKTVVGPDKAVPVYPKDTSSVPNRTDGTSDSSVNRLAATGNTLGESAFGSGMDRNSGTIPEYLSTGSEDLRPLSKEEAERLYEERMEEEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW0</accession>
    <name>A0A370PUW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_323769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="38067" checksum="6419BEA53B94FA18" modified="2018-11-07" version="1">MVALTEARASNRQLTPATVPQVSVFVGATSGIGKATLTELVSTGFPMKVYVIGRDEAAFQPSLAELRALNPCADMIFLQGEISLMAETKRLTDIILRREGGETGGGVDLLFLSSGFLPTLERQETTEGIELAAAVSFYSRQVFIRRLLPLLRMQAAAAPRTPQGSFLSFRPRIVNILSTGLETADLYLDDLHLKEPGHFTFASYAGHVTTMTSVSLKQVAEQEQNREIVIVHHNPGLVFTDIFKKSWGDQWDESKPADGPSVPADIERSTPTEAGERSLYVMTTAKYGGDGVSLGDKQQTGLTVQGTKDGSLFCVGDKLETLDNGDLLQSLVDSGAADAVCAHTERLIGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV23</accession>
    <name>A0A370PV23_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_323822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="557"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="744"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="149795" checksum="EC69B33029463C00" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVW0</accession>
    <name>A0A370PVW0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_229059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVW0"/>
    <dbReference type="SMR" id="A0A370PVW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="51209" checksum="ADF6FD8430C78CD2" modified="2018-11-07" version="1">MSNIFDDFKEGQKIGSGARLAASLSPVATAEYPDRLKSFYYFSNAAHVSADLRYSLFQANGLRLPKQEQNSWVDIFTAYWKAVGEIVRFDDSPRHASWVKVFDAWKDTANQLIRGYSTGSLQAWTVPCLYSVGRYLRAFAMKADAELSAQDSVTFDDRFQDDATDAKNPKLEEATRVLNRMFTLCLSDRAPIEESRKWGIYDTTNLLFKTYFKLNTVGLSKNLLRALNASSADLPGLDAFPKSHIVTFEYYVGVIHFLDENYAEAEEHLSYAWRMCNKHATKNRELILTYLVPCHLVTTHTLPSKKLLAPFPRLEKLFRPLCDCIKRGDLGGFDAAMTAGEEEFVKRRIYLPLERGRDIALRNLFRKVFIAGGFDEPKEGQPPIRRTRVPVAEFAAALRIGTHADDRSRIDIDEVECLLSNLIYKGLMKGYIARERGMVVLSKGGTAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW02</accession>
    <name>A0A370PW02_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_332961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1399" mass="154236" checksum="B2F55577D5EDEE36" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWI2</accession>
    <name>A0A370PWI2_ASPPH</name>
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK46549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="209" mass="24320" checksum="8E02BB27B587391F" modified="2018-11-07" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILMPNMYQNPAYDPKSKMNPSQLQNHFDAFYEDVWCEMCKYGELEELVVCDNNNDHLIGNVYARFKYEEDAQAACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKDPSNELDRDLRLSTKKWLKERGRDARSVSRSPSPEPTRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWX5</accession>
    <name>A0A370PWX5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS phospholipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_244680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="54096" checksum="CDB2FB921D5FAA7A" modified="2018-11-07" version="1">MMDRGDEKTKELVVSPHGDPHIDEDPLADSQKSFWERSWPTFACGAGLWSDGYLQYVIGTVNTMLDKIYPKIYDGSTYSQNVSSIAFAGTVVGMLFFGYLSDHWSRSNTLMVSTVILFVFGALCAGAYGHNGSLPGMFTALTVYRFFLGLGVGGEYPAGSVAAAESSGELAEGTRHRWFILFTNFQLDLASVASSLVPMIVVLATGENHLRAAWRICLGLGVIPPLSLIYLRMKLKEPAEYTREKMNKFPVWLIVKFYWKRWCVVALIWFIYDFSTYSFSIYSSAWLADIIGDNAPMWQTLGWNTLINVFYLPGSALGAFLSDWYGPRNTLAFGVFVQGAIGLIMTGCYPYLDTPHYVAAFVVVYGIFLAMGEVGPGDNIGLCAAKTCATPIRGQYYGTAAAMGKVGAFVGTYVFPIIVKNAPNKVRQGQDPFYVSSALCIFSAFLAFFCLPHIGQDTITHEDARFRAYLESHGYDTSSMGTTGGQRQTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX31</accession>
    <name>A0A370PX31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-SNARE/peroxisomal membrane protein A fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_288884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="234" mass="26301" checksum="FA9A86B0825A34EC" modified="2018-11-07" version="1">MSAKFQDEAVTSIREDTKELVHKVGNRLTGDGYLALYLRQLQSNPLRTKMLTSGVLSSLQEILASWIAHDVSKHGHYFSARVPKMALYGMFISAPLGHFLIGILQRVFAGRTSIKAKILQILASNLLVSPIQNAVYLCCMAVIAGARTFHQVRATVRAGFMPVMKVSWVTSPIALAFAQKFLPEHTWVPFFNIVGFVIGTYVNTHTKKKRLEALRKRYDQRRGPGSEYDKGDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ31</accession>
    <name>A0A370PZ31_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_271777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ31"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000003">
        <property type="entry name" value="Anthranilate synthase component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="57112" checksum="F06FD58F525BE8E0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZE8</accession>
    <name>A0A370PZE8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_271870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZE8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="107"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="383"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="661"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122479" checksum="0C04E1A96C15C1A2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZH1</accession>
    <name>A0A370PZH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_316509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="506" mass="55863" checksum="DED85139DB203120" modified="2018-11-07" version="1">MSMETKTDHERTDTIDPLAQPNIKTELGNGRENIDPNAPVRVRRGFLPWLCMVPSVQDPRSYSSGVKWFLTFIVAAGGLVVPLSSGVLFPCLLEIAADLDTTESVVNLSIAFGSLAVAITPLWWSYIAELYGRRLVYLLSFFFLGVFCILAAISPNIDMFIAMRLLGSASSASLQSVSAGTISDMFDTRERGKAMGAFMLGPMLGPMFAPIIGGALTMRWGWRSTQWFMVIYGWTVFMVMVFFLPETATNLAETQREHRANASSPVKKAAHFLLKPIEAAKLLQYPPILITVYYTAIVFATYYLICVSIEDTFAVAPYYWSPVIVGVAYIPGGLGLLFGAIIGGRWQDAIMARTARKEGRYDDVGELILHPVDRLGENCLMAGILFPGALLWWGWSAEKQIFWLVPLIGNFFYGFSGMILTNVTMTMLTEFTPKKSTVGVAVNNLLRNSLSCVSAVIAQPLFDAIGTGWSFTAACLFCLLSGIPLILLRMKREKWSRKMKATLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q060</accession>
    <name>A0A370Q060_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_316593</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q060"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="49996" checksum="330002C2649FFE6A" modified="2018-11-07" version="1">MQVPLLRLQCGVNSYDWGKIGHESAAAKYAAITAGSDFSIEPEKPYAELWMGTHPSLPSKDVETQRTLLDMVQDNQALISKEVSERYGGKLPFLFKVLSVQKALSIQAHPNKKLAEKLHARDARNYPDDNHKPEMTIAITPFEGLCGFRPLAEIVHFLNAVAPLRELVGTQAVNQFESVVKGSEDSQDSDKMARNKDALRSLFTSLMKSSPESIEAATQKLISAAQDSPDTFATSTSTPETNPSNPAELAAIIARLNGQFPNDIGLFVFFFLNFVKLAPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLTEMLTYSYAPIEEQKLEPTDYPYAVLNASAYSSGSSSLLYDPPIEEFSVVKTDLKRAGAKATFDALVGPSILICTGGTGKITVGHKTEEVKEGYVFFVGANAECIVESTGSGEEDVFTTYKAFCDLTGKEDMVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0B0</accession>
    <name>A0A370Q0B0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_331620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0B0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="447" mass="48717" checksum="2F327D9056FB2DE8" modified="2018-11-07" version="1">MENSGAATAPSCGAAEAGARLESSEFPTLDCFGFSAATVHYQDEVDDPHRPALPAASPLSAAALTATVPFPSLDDLTPTAHTNSYSKSEPSSPGIISASTPSPDSKAPFVRGHRRRSTHVTRRDLEKFRKEVLGLETSGFGFDDDHNLPKPDPAVDPEFTLLNNAFDTANMSMNSSGGMTGSSPGSAMFASYGDGSGGASGMPNVPRPSMSPAMPHPPAQVNGGGMPGMNGAVPMNAGHQMDLHHLYDMVLELSDVLKNNREMTKSIVTSAEEIMKRSGSEGANPTLQQVNGEITGARITELERALAKERRLVEVLRTEQAENAKLIGEYEATLGTMVEQIRNYCQNNNMHYLSQKRHYNNLLQAERDSHLESRLDRDYWHAQTMKCAEMIRTAYRLRSEEEELPIRIVAGLQNEVRAYRNALGMEPERPEDEFGWEILKDVPGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0H6</accession>
    <name>A0A370Q0H6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_331682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0H6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="326" mass="35109" checksum="2806A2B5415ED70C" modified="2018-11-07" version="1">MAPALGQIFPPNPTFVEKDMPDLTGKVTIVTGATSGVGFNTASILYSKNATVYIAARSADKARTAINEIQTSAEGAHSRGCLSFLQLDLSNLASIKESANKFLELEDRLDILIHNAGVMTPPAGSKTITGHDLEMGTNCLGPFLFNKFLLPLIQRTAAAAPASSVRVVWLSSMISSFTANGGIIFDEETGAPKVLSDPMQNYMESKVGNVFIAKEMANRYGGEGILSLSVHPGLMKTELQRHSSAIQATVMGWIFKGPRYGAYSELFAALSPEVTQEKNGAYIIPWGRFGPIPCHLQKGLVSKRDGGAGTAERFWSWCEKETAPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0N6</accession>
    <name>A0A370Q0N6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_8947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0N6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="57440" checksum="EF941784C73DAA96" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Z7</accession>
    <name>A0A370Q0Z7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_10701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Z7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="57" mass="6628" checksum="E0C74792E36E66A1" modified="2018-11-07" version="1">MLDRRNEWMEDIKRINTRSLSLILSGSSNDCFHIILVLVINGFMTSSFSRHVSHHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q132</accession>
    <name>A0A370Q132_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_11392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q132"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28763" checksum="DEDEBC6693080A7B" modified="2018-11-07" version="1">MFSTSRRRILDGLNRRYIYGRLPLLHAIIFLIEMAAAMRLAAKFNSYYAEKPILTTMVTNAILGGIADTVAQLITAFKARGGRRPSDSNDLISIEIHDLDKEKPPALGELGHARHMPPPFDFERLTRFMSYGFFMAPVQFHWFGFLSRAFPLTKRNPSIPALKRVCVDQLMFAPFGLACFFSFMTVAEGGGRRALTRKFQDVYLPTLKANFVLWPAVQILNFRVVPIQFQIPFVSSVGIAWTAYLSLTNSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q165</accession>
    <name>A0A370Q165_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CT20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_7224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q165"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="281" mass="30553" checksum="27A591D725AF42A8" modified="2018-11-07" version="1">MPPRKKAKLTPQSENAEPSASTTDQPTTADYDPVTDPWTDEQETALLKGIIKWKPVGMHKHFRMIAISEFMKSQGYAPAHAEHTRIPGIWKKLGTLYNLPALDEREDSLITDTAEDSKEFYCPFELPQDEYGELMFERRLAMEGTASPDPSTHAGSRRGSTVADTDEPRSSPAPSRGRKSGRGGRPAGRGTRSSRLHVEVEPPAKGSGAAEEEADSGEETGANEEGDEDGSDAAKDDSEVDEEAEGGSPTTRSTRAQTSRTKQKGRGTAGTGTRRGRRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q189</accession>
    <name>A0A370Q189_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q189"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="327" mass="37220" checksum="F4A61E7EBBBD2189" modified="2018-11-07" version="1">MAHDLLQRKDVALKVMALGEWAENEIRMQNEIIQHVQDTSSLVTYLDAFILPRDNDHHQVLVFPLKGPCVDPVLLLKMPPTARMPAARKLLEALKKLHQAGIVHRDLNDRNCMWGMAPLHHLSRSAKHKALGRPLRQVIDDIDLWKRGELVQPLQVPESLRTEDFYIGDFALAKKVGESATQRGYPPMHFCSPDRLHGKETGPACDMWSYMILFSEVYLGIPPFSTLYPGGILSAITKNLGPLPEEWEGFYVFSGGLDSWYDQSQGPDPDSLEFLVSYHRPDADPTERQHLLTLMKKMFIYCPEERLTATQLLQDPSFKAIMDNYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1D8</accession>
    <name>A0A370Q1D8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_244478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1D8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="108"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="26188" checksum="E7B25B2CE153A73D" modified="2018-11-07" version="1">MQTTLGRALFKMTKPLLLHAHATGPNPIKVAIALEALQVPYEVQQWEFGDDPQKGVKGEAYLKINENGRLPSLQDPNTGVVAWESGACMNYVRRVYDRDGQLGPVGKAEQDIVDLEKWEYFLLTNLAPMLGQVNWFRNYHAVKNQDALDRYTEQAYRCFGVLEGQLKKSNGESVLPGKITAVDYHSEPWVRQYSFAGLSLDSYPLIQRWLAGMAGREEVKRAYVKIKGKGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1G9</accession>
    <name>A0A370Q1G9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1G9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017083709" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
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        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="941" mass="102175" checksum="4B15C8666FF83A8C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1P2</accession>
    <name>A0A370Q1P2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_323184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1P2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="419"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK48335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="60521" checksum="D018B0FA2967A159" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3J2</accession>
    <name>A0A370P3J2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_125387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3J2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="225" mass="25311" checksum="63671063974C8023" modified="2018-11-07" version="1">MSPAPLTKTLEFEKKNQNMPKLPKHVKVQKRPIPHPSTPSPYSGSSSPKTIYVSSSSPTMGVVKRVQKYLRAAENRATAKLLSGNNKGKKGDRRNQFAQLAQSNEALKKEEVFVKATGRAMERALKVGKWFEARGEEYTVSVKTGSVLVVDDVVEDEEEREKAVEESERMKKEVEEAKLKGENAELSKSAMRKRKRAVARLEGEEELPETRTRWVNMVEVAVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3X0</accession>
    <name>A0A370P3X0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_287721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3X0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="483" mass="53175" checksum="60F85A1A691C639E" modified="2018-11-07" version="1">MAEVDTKASSRHVESTGKPLDVVDESFEGLTPEEERALENRLVRKIDLHLISSLFLLFIFNILDRSNIANARLGGLQEDLGLSDTQYQTAVAIMFVGYLLGQVPSNILLTRLKPSRYIPAAIFIWGGISICMAAAHNFAGIMCVRIFLGFAESPFFPGALLLISSWYKPSEIAVRVAVVYCGNTIANGFGSMFAAGVMSGLNGKGGLEGWRWLFIIEGAGTMVAGLLAVALLPDFPRSGQRKWLSEQEQRFAEWRLARAANDEVDENGSIREGLRDAFLDPKAWMLILIQVCQLTSQSWTYFFPTIVKTLGFSNIITLLITAPVYVFGFITALGNSFIANRTSQRAVLIAWPLIVDIVGNVMVISSRATAVRYIGMFLMCAGSYSAFNVVQAWIASTIPRTRTKRAIVYALVNLFGNSSNIYGSYFFPTSDSPQYRPGGITLSAFAAAGIVLTGLLALYLHTLNVKAQRAEDEDGQIRYKYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P485</accession>
    <name>A0A370P485_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_298944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P485"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="220" mass="24038" checksum="869169A1B1DE1A60" modified="2018-11-07" version="1">MDPNMNSLLKWSIKAATEEQSSGENNNNNNSGNNAPADPSRGLTPQMLSTLFGGPSEADLMKAAMEALRSDEVDLENKLIAFDNFEQLIESIDNANNLEPLGLWTPLVELLDHKEPDMRRMAAWCIGTAVQNNEKAQDKLIVLNALPKLVSIATTDTTPVVRKKAVYAISSAVRNYQPAMDEVTKSLPEGYSHDKIDAGDMDAVDALMDKLRAHKVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4M9</accession>
    <name>A0A370P4M9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4M9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="42055" checksum="5D62FE3C86F3327A" modified="2018-11-07" version="1">MPRIPSRTILDAYQQDPLLPLLLQECRSLDLAKNELGWLRSRAVSIAQSKSKIETFRTKPFQGWRSSLRSMCRARSRGKPLQYILGDQPFGDLDILCRKEVLIPRPETETFTFHAANLISRNVANASQSRIKPRAISVRVIDLCTGTGCISLLLHALVAPYVRHLSIVGIDISTAAIDLARKNLKYNIRRGKLLNRAMVDITFKQGNVLCGAPVDASHVEQALGGTPEPTLRTACHLDVIISNPPYISEKSYGNGTTARSVRMFEPRIALVPPVIGDALKLPLHQQEDIFYYHILSLSFKMRVKLVILECGDHSQGERVASLCRALAAQYSQVDDLCISIWPANDATVNDSAREVSEPCMVIVQRSGLGNDSACDQPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P588</accession>
    <name>A0A370P588_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_287378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P588"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="32383" checksum="82D23439BA4212BB" modified="2018-11-07" version="1">MEHPISLCQRCRVLQFNEQDYGTVENESLGNCTVVFDHFDDEDYYEDDPFYEDDQDIRRQEISLDYQLLDKFPDFWFLRHPLHLDVIVSIVCNGSKACIRDKGNTVSRNLDRGILYQPSLATPRHEIIGSLRTPLDDEESIAPSWSWVSNPNPVKWGGETNNFDPLFMCQSKIASINTKTNLNPYGQYVADVRFDWTHDSSEAQTHSTEKEKDILNMLSMVLILRYDGEEEDFMMGLLVLPTNMPSVYRRSGLFSCENGQEFWYNIDTPIVALVCFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P599</accession>
    <name>A0A370P599_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_340132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P599"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016835055" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="22560" checksum="27353F8069693658" modified="2018-11-07" version="1">MRLAASLVICLATLVCAREWVTTTEIESQRLDEDDEAASSMEEIGVETGYSITCYDSTRIPACDVAEVITLLPAGPQTTSIHDGMIVVDGDELLYSTQMTAQPIEEEHSSSISDTVTAETTAEASDIEVTMSWSSSSLPASTHMMSRTTSGSVSSTLSAGPGVESVQGSMSLMTTQSRASSTSLTSSSARSTGAAPIATGELAMMAGAAAMVLLVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5B1</accession>
    <name>A0A370P5B1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_259558</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5B1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="312"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="629" mass="70625" checksum="CE1277B632357C5C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R8</accession>
    <name>A0A370P5R8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FSH1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_330527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="31144" checksum="01CEEB85A1E777D9" modified="2018-11-07" version="1">MPPLKLLCLHGYTQSGTLFHAKSRAVIKHLTKTLLPTTGYTITTTYPTGPIHLLPSDIPGYEPSTNQGGTNDEPTEAYGWFRRSSTANPPLYTDLHLGLETIANVIKTEGPFDGVVGFSQGAAMAAIVAALLEPGREEVMNKFASEGSVFEETGENVKGFEVPSVWWENVRSVGQAPLKFAVCYSGFRAPGPRYRGFYEGGVKTPVLHVLGSLDAVVDEGRSKALVEVCDAKDVEGRVVVHPGGHFVPAQRPYLDAVVGFVRGVVGDVNGNGGKKEKEEVDVNEMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6G6</accession>
    <name>A0A370P6G6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_92274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6G6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="182" mass="20117" checksum="9E5A12F03BA8BBAF" modified="2018-11-07" version="1">MFNPISKLVRRGDSGSNDGLSPTMVDLLISLLVLILLGLALVGALLVLRRKRLNREQSELPVHNGQCVPNHRRFTVSASPNAKTESVLVYDEKRSLIENSSSPPPSPVPEIRITFPEEEDESGKRKSGRVVVVRITDAGGVGLEPCNEELPPYQSSDAERFQSLDIERMGGLKEKESTNRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6S3</accession>
    <name>A0A370P6S3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_279585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6S3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30541" checksum="0D9952F2776F73FE" modified="2018-11-07" version="1">MTNDTKQKADTAANSDGEEEDVFHDARFPAEEETRLLEESHTIKAEANKLFTAACYDQAISCYDRALASCPNYLDYEVAVLRSNMSACYLKLEDWKASVDAATACIDRLDKVVPPATGAVDAEGAKGKQPQESSGEDAVVEITGDDDEAEEELKRLQKQDEKKRDVLRIRAKALMRRARAKMQLGGWGNLQGAEEDYKELAAMDNLPPDDRRVVQKALRELPAKIGQAREKEMGEMMGKLKDLGNGFLKPFGLSTDNFNFVQDPKTGGYSMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6X8</accession>
    <name>A0A370P6X8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_297972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF10">
        <property type="entry name" value="CHAIN DEHYDROGENASE_OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="30765" checksum="6FDE5BC1436C9513" modified="2018-11-07" version="1">MAGHAHVKERLPRSEKAQERFREFSLAGKVFAVTGGARGLGLSMAEALVEAGGRVYCLDRLPEPDEEFHAAEARANPDFGGSLHYRRMDVTDDANTEAVIADIAAQNSRLDGLVAAAGINCVASAIDHTPKNVDDVIHINYTGVFRSAVSAAKAMLDVKCHGSILLVASMSGIIANKGMESAIYNSSKAAVIQLTRSLAMEWSEIKEDGTGGIRVNCLCPGHIETPMAKMVMEKDPDTRDLWASENMMKRLARPEEFRGITLLLMSDASSFMTGSTVVVDGGHTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7L3</accession>
    <name>A0A370P7L3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_82034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7L3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="62" mass="6992" checksum="F3325DC35BAB51C2" modified="2018-11-07" version="1">MDRIFQPVATGNKVIVTAFNVGSLSRAVSRMPDLEWLRGHAESEWIPQKLLHAKVLRTFLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Q5</accession>
    <name>A0A370P7Q5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_279171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Q5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="44927" checksum="3C6A85FD140F6B70" modified="2018-11-07" version="1">MPTTRPIVRAACHNLSGIRHASTSAAKKAGPLAGITVVSLEQAIAAPFCTRQLADLGARVIKVERPGVGDFARNYDTRVNGLASHFVWTNRSKESLALDLKKPSDHSVLMRLLGRADVLVQNLAPGASARLGLSYADLKAAHPSLIVCNISGYGPDGPYRDKKAYDLLIQSEAGMLSVTGTGKEPAKVGISIADISAGSYAYSNILAALYQRERDPSKRGCNIDISMLESMVEWMGFPVYYTYENAPGPTPAGASHAAIYPYGPFETGDGTVMLGIQNEREWAKFCDIVLGQPSLATDERFVNNSLRSQNRDELKRIICDVFSSLSAEQVIARLDEAAIANASVNDMQGVWNHPQLKARQRWTDVETPAGTVPALLPPGMTKGDEDTYGARMDAVPDVGEHNKAILAELGLDEGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Z2</accession>
    <name>A0A370P7Z2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIP transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Z2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="617" mass="67707" checksum="BC4F895497289F55" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8N6</accession>
    <name>A0A370P8N6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_307102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8N6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017035551" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="27935" checksum="4DFC4B4D00AC30C7" modified="2018-11-07" version="1">MWSLSSRALMATAALLGSLPSTLATSAACNASALNTTVGLYPITVENTTVFDVAKATNRGVCDIGRQNLMADVTIIPNVGQTLIIPAEVCEPDNETCLLPNITRTRTCINGGPRLYYTVNGDTLDIVAKRLNITTESLMSDDTSFTADEVLAPGQYLKVPLCSPSECVIRPFTLEYGVYKDYADKYNTTVGQIMMLSPTYNYSTSPLTGAGRPSLDLPYKFLLWLLIIITGHYVSVDVFEFLSYSTVIARRAPMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Y8</accession>
    <name>A0A370P8Y8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_338838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Y8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016986353" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12267" checksum="6AEC4451B32AC38C" modified="2018-11-07" version="1">MQFTATILLLATAVTGAIAAPGALEQRDNSIQIKACDGQNLGGTCSTITVGIQHDCFNLEDKAVNDNVHSVSIPRGYRCRFWETDACNGGGTGDIQSPGSDKISSNRVQSVKCYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9U5</accession>
    <name>A0A370P9U5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_75669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9U5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="55768" checksum="DE83DAB70E141673" modified="2018-11-07" version="1">MFPSRAFLRVRSLLLAIFILLTFAWSYSRWRSYPLPEQVQSIQTHQQPLSSNRHTEGHIQFWRQFQPLLTAHEPKCEPPLRLGSAPSIRFEQSNPEDRPELLDMLPFDVDMMKNAHSGFVDAINTNPPQLNYTKNTRGLVSTAGGSYLPVLVISLRMLRRTGSKLPVEVFLANEEEYEDHICEVVLPSLNARCVLLSEILDAVPGDMRVEKYQFKLLAMLFSSFEEILFLDADAFPLHPPEMLFVNGPFPSTNMVTWPDFWASTVSSYYYEIASQPYPENSVRQSSESGEVLISKKTHMKTLLLSTYYNMWGPDFYYPLLSQGAAGEGDKETFVAAAMTLQEPYYQVSEPICAIGHGTQGGLAGSAMVQFDPIEDYALTQKGEWRVHGSKAPAPRAFFIHANFPKFNPATVFDKQAVNPAFADDGSYTRAWTIPNEVIKAFGTDIEKRFWDEILWTACELEDKFSTWKDKKGICKGVKNYWNAMFGIGHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9V2</accession>
    <name>A0A370P9V2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor IIIB, Bdp1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_329521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9V2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000322">
        <property type="entry name" value="Transcription factor TFIIIB component B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017174">
        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="420"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="578" mass="62981" checksum="AFDB75C4EFBA049E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAB4</accession>
    <name>A0A370PAB4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-actinin, sarcomeric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_221058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="670"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="917" mass="103753" checksum="30C72816DC0FEE50" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAJ4</accession>
    <name>A0A370PAJ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAJ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40051" checksum="A8F50CD9035E792D" modified="2018-11-07" version="1">MYSKFWPKGGLPGILHHFTETLVTFEYTTTTPSLAQPHTLLFVGGLGDGLATTSYMADLARALHSTPWSLFTLNLTSSYQSWGLGHLDRDTDEIAQCIRYIKDYKADKYGSASAAGSKIVLMGHSTGSQCVMHYLTRPNPHTTKPPFDKYLEHVERLPLDGAIMQAPVSDREAILWVLENGFGGRSSAECKAVYEKLVGMAREAEEKRIREGGEFDVILPIELTSFAYPANTPLSARRLLSLVSPDAPGNPGEDDMFSSDLGPEQLEKTFGKVKSGGLLAGKAKLMVLYSGKDQSVPDWVDKEALLRKWRGIANAGCAKGEEVWDDEHTAVIPGASHALSNDDQAEPRRFLVDKVMGYLKTVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAL3</accession>
    <name>A0A370PAL3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_338558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="418"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70912" checksum="9E9BF0E17A26B321" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAQ9</accession>
    <name>A0A370PAQ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAQ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="83" mass="9438" checksum="79C0A3D9255EEAEB" modified="2018-11-07" version="1">MDLVQKYGHLKHDRRRSSLQQQLAEEERHRNQMAINSLLGSFGGSANDHPDRRSSGAGNMASMIEEFNKRKSVSPDTNVEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAX9</accession>
    <name>A0A370PAX9_ASPPH</name>
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        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_338228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAX9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="263"/>
        </location>
    </feature>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65205" checksum="AF0750C0C6CD958C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB94</accession>
    <name>A0A370PB94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="418" mass="45985" checksum="023149641352BA6D" modified="2018-11-07" version="1">MTNSILNSSLMQRPRKMKCLSSIFLPCLQARKLRRQRRQDYHASWTCAGISELAQPTEPFPAYEHEKHHHGSTELSALPDQPTDAVTKTPQMTPSIRLVNPADSECSTLDDPDEKQPQGIQDDTAAKQTTTLSDDDTDVESSSEKTSRVIDMKVGPQTEEPLNPKAHLSLKSKDDIDLELSSRRIPRSPDKKPRPASMDVPPSAAAKLPEIKSRIIEDIPEDVEEEDKHDSDIKHTVSAVPDEQAKPEEEHGSETAATKPTKRTSTWRLSQRKSMNELFNLLQSTAAAVAAAPKLSNLKFAIPPKSPLRASPTNDSPHHSYVSSVSSTSNRPPTPPPKSPVLRPNSRPLPDPAQLSSSAPPASGISLGSLSSSPTKKQRRMGTAVFPLLPCKWAGIHDEDMKEKHSNDTNRNSQTLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBG1</accession>
    <name>A0A370PBG1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_49837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBG1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21513" checksum="FAA2041C77D8FAC6" modified="2018-11-07" version="1">MLSDLMHCWEFNRSSIIPWKGGFIDFIYPGGLALFHSRPPFFPVFFFARQLHSAGRVGARSSRLVYMWVCFLFNHRNGILVIYILLMGYWVDCPEGTVGERRERKRETASCLDLTVQNRRQQERAHTAGNHSTVDAGGAGWISFSFSRPVILLFFFSLFLSPPSSLSIPSLSGSHTSVYHFLCHVMCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBZ0</accession>
    <name>A0A370PBZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBZ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="41257" checksum="A87A0DE286794715" modified="2018-11-07" version="1">MTTINGHCDPAFTRVRDLLQQLIDNEEELGASICVNTDGQNVVDLWGGHADPARTKPWEKDTLAVVWSVSKVITAIATNILIDRGLLDPNEKVSKYWPEFAANGKENILVSQILSHTSGVSSWELPNTLDDIYDAKRGADKLARQAPWWTPGEHSGYHVTNQGHLLGELVHRVTGKPLDEFIRDELASPLAADFQLGVPEKDWPRTADVSPPPPLSLDGVDPQSVMFKSFASLPIPAEESMSPGFRKALIGATNGFSNARGIARIASVISLGGTVDGKQYLSPETIDRMLEEQISGPDLVLMYHLRWGLGVGLPVPETFPWLPDGRIAFWTGWGGSVVVMDLEKRMTIAYVMNKMGQGTLGSDRTAAYVRAVYDCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC05</accession>
    <name>A0A370PC05_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_320644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC05"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016763538" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="35746" checksum="B1AECAA8FE3BEC59" modified="2018-11-07" version="1">MHSFASLLAYGLVAGATFASASPIEARDSCTFTTAAAAKAGKAKCSTITLNNIEVPAGTTLDLTGLTSGTKVIFEGTTTFQYEEWAGPLISMSGEHIHRHCGKKKPKFFYAHGLDSSSITGLNIKNTPLMAFSVQANDITFTDVTINNADGDTQGGHNTDAFDVGNSVGVNIIKPWVHNQDDCLAVNSGENIWFTGGTCIGGHGLSIGSVGDRSNNVVKNVTIEHSTVSNSENAVRIKTISGATGSVSEITYSNIVMSGISDYGVVIQQDYEDGKPTGKPTNGVTIQDVKLESVTGSVDSGATEIYLLCGSGSCSDWTWDDVKVTGGKKSTACKNFPSVASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC39</accession>
    <name>A0A370PC39_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_255503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="851" mass="96120" checksum="DA7FC17B1369D348" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD73</accession>
    <name>A0A370PD73_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Class V myosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_255185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1232"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="915"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1572" mass="179457" checksum="FD426DE73EAB3716" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD94</accession>
    <name>A0A370PD94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_39478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="31344" checksum="CBACA8A3AC94B6BD" modified="2018-11-07" version="1">MTVSTQVAGFHLADGKGYTLGHDSLAMCRLNLQIFLWRASLGFTLHPSIPLPTTGRIADLATGTALWLTELAQALPADANVQLDGLDLDLSKAPPHPWLPANVHLHQADILAPLPDPLVGQYEVVHLRLLILVVENSDPTPIIRYAHRMLKPGGYIQWDDLNYPDTHVTRINPTSPTPAFDRLREFVYSKGRHDWVMRLDKILTREGFVGACMHHFTDRRDLIMANGHQHLMTMLEFAGTLRAKGLELEARDLDILLAEVSTEAARGAALSMPRVVCVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDH1</accession>
    <name>A0A370PDH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="242" mass="27100" checksum="21D529EEE89C7D0C" modified="2018-11-07" version="1">MSSSLVPNAHLPLGPTMDLGTDPTAGQESYRQERARIKHWKQGLRWWFPSGERFFITEENDVDTYNIPINMLRVSHCDSPMTFDIILGYTDIEERNPHVQFLANRVRPPVKPMVDPRDAKVYHPCGATVIGATVVGAPVIEDLVAIYERIGDNPLSFKEADRFPQRVSKVAGEDSPLADILREIKISFEKTAVRDGYADPETPSSSSPARRVMNGLLLLHMTAVEMTFLFVPILGHTEAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEG8</accession>
    <name>A0A370PEG8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_218092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEG8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="743" mass="80117" checksum="09A8D4DD3091BE26" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF25</accession>
    <name>A0A370PF25_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_277467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF25"/>
    <dbReference type="SMR" id="A0A370PF25"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000015">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="13771" checksum="4A783A6FBE04C773" modified="2018-11-07" version="1">MGQHSAIWQGYVDSSLMGSGQFDKAGILSHDISGVEASSPGFTISPQELQGLAAAFKDPNAAWGNGITVGGEKFVTIKADDRSLYGKKGKEGIVVVKAVSCVMVAHHAENVQTPNAATVVENLVDYINNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF68</accession>
    <name>A0A370PF68_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_277491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF68"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="710" mass="79725" checksum="A1E534302DCC1327" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE4</accession>
    <name>A0A370PFE4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="275" mass="31387" checksum="6CD3F2DA3C6974E8" modified="2018-11-07" version="1">MFEVYIGRLKFMAQALDKAGINNVLWGDAVKSLLIHPEIPKRIDYIVSDGMTGKACQALLADGLEACKRGEQCMVKQPWNGPVAAAHAHLCSTGIGEIDLPVVFWDKSSLLFAFPDLPSSPLSSDDPYYMPIRIPRTHYDPTARCPPLDLAPARMIRPVKTVEALIWLMCRDRTPNGQLERGWEDEWVKALEFWLQEATRLAEKGLFALHELRPDFAPLWYFFCNGEVSRTSKQYRACYLRLQEKLRAENALPLTPQMRNEKSQAVHLKWSMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGF9</accession>
    <name>A0A370PGF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="264" mass="29573" checksum="80CE52775FEF5215" modified="2018-11-07" version="1">MADMKQSEKASALSDFRVLSFDCYGTLVDWESGFIKALQPLLSQLPDTHPFKSSAPEILSIFQKIKAQIFKAQPTLLYSQILQQAYFALAQSLRGPGDPGPSTSLEAERFAASIQDWKAFPDTRDALQRLGRHFRLVILSNVDNVSFRRTLQGPLEGIHFDAIYTAEDIGSYKPDHRNFAYMFSHLRADLGVQEGEVLHVAQSLVNDHVPAKELNIKSAWITRGKEGQKGMGGALQDLRDKVAFSWRFADLSELASAVERERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGK0</accession>
    <name>A0A370PGK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="27325" checksum="91CFD6A38340BA58" modified="2018-11-07" version="1">MTKQLAPGARLEGKVAIVTGAGSGFGAAIAQRFASEGAKVIVADISSEGGQKTAAADPENIVFEQMDVTKAADWKRIVEKAVSLFGKLDVLVNNAGTTYRNKPTLEVTEDEWERVFNVNVKGVYLGSQAFVARVIEQGQGGSIINISSTGASRPRPGLVWYNASKGAVSNATKGLAAEYGPHNIRVNSVAPLLSATPLFSVFTGMENTPENWEKFIGNVPLGRLTEGDDVANICLYLASDEGRFINGTEMVIDGGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGT4</accession>
    <name>A0A370PGT4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkaline protease 1</fullName>
            <ecNumber evidence="4">3.4.21.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Aspergillopeptidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Aspergillus proteinase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Elastase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Elastinolytic serine proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Oryzin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_294255</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt &gt; Ac-Tyr-OEt. Does not hydrolyze peptide amides.</text>
            <dbReference type="EC" id="3.4.21.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18 19">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.63" evidence="4"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000008">
        <property type="entry name" value="Alkaline protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18 19" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 18 19" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016787750" description="Alkaline protease 1" evidence="20">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="22">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="21">
        <location>
            <begin position="155"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDK41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="43887" checksum="6FDF3934076C20B9" modified="2018-11-07" version="1">MAFLKRILPLLALILPAVFSATEQVPHPTIQTIPGKYIVTFKSGIDNGKIESHAAWVTELHRRSLEGRSTTEDDLPAGIERTYRIANFAGYAGSFDEKTIEEIRKHDHVAYVEQDQVWYLDTLVTERRAPWGLGSISHRGASSTDYIYDDSAGEGTYAYVVDTGILATHNEFGGRASLAYNAAGGEHVDGVGHGTHVAGTIGGKTYGVSKNAHLLSVKVFVGESSSTSVILDGFNWAANDIVSKNRTSKAAINMSLGGGYSYAFNNAVENAFDEGVLSCVAAGNENRDAARTSPASAPDAITVAAINRSNARASFSNYGSVVDIFAPGEQVLSAWTGSNSATNTISGTSMATPHVTGLILYLMGLRDLATPAAATTELKRLATRNAVTNVAGSPNLLAYNGNSGVSKGGSDDGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGY8</accession>
    <name>A0A370PGY8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_217047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="198"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="66023" checksum="C05B7BE9B6A41132" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH19</accession>
    <name>A0A370PH19_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_235762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000041">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000009">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="472" mass="51561" checksum="6505AE253AB7BA69" modified="2018-11-07" version="1">MNILRSTGSLSRALQLCHGPRTLPTIRCQARPLPRRRFHAAASLWGVKSQVLKDVGEGITEVQIIQWYVEEGAYIEEWKPLCQYQSDKAVDDITSRYEGVVKKLHFQADDTVPTGKALCDIEVENGKYPDDNPPPVPKTEPIEPTPARSPLTETQPPQPTQTAPSAPGNGITNNGPKSRHATLATPAVRGMLKIHNVNIEDVQGTGKDGRVLKEDVQRFIAERDQAPSAQLTAPGVQEETAVKLTPIQSQMFKNMTNSLSIPQFLYADELNVNNVMAIRKRLANDPKDPKKISLLSFVIKAMSLALNDYPLLNAKIDTTDPAKPQLIMRAKHNIGVAMDTPQGLLVPNIKDVASLSILDIAAEILRLNALAKERKLTPADLSGGTITASNIGNIGGTYVAPVVIPNEMAILGIGKSRTVPIFDEAGQVTKGELVNFSWSADHRVVDGATMARMANRVRELVESPEQMLLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHY0</accession>
    <name>A0A370PHY0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_19758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHY0"/>
    <dbReference type="SMR" id="A0A370PHY0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="546" mass="59779" checksum="F936024A06AD6CD0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI12</accession>
    <name>A0A370PI12_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_20165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="169"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="425"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="480" mass="53808" checksum="F60FBCBF9D634EBF" modified="2018-11-07" version="1">MPSLGGLLKKRRTKDSQTLSKELEAGSAQTQTSPNAAEDHHNHNHHQHHHHLFHHHHQPQPATNSGSAANTPSQPQDSVPQQSNRSSGAEKSSDGQVASMQSAVTQASPSAHHTSGLPQPNANAASIQNIINPSQQGAMHSASSGQTQSHHAGRSDARTTKGKYSLDDFSLQRTLGTGSFGRVHLVQSKHNHRFYAVKVLKKAQVVKMKQIEHTNDERRMLNRVRHPFLITLWGTWQDSRNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHTQNIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGFTPFWDSGSPVKIYENILRGRVKYPPYLHPDAVDLLSQLITADLTKRLGNLHGGSDDVKNHPWFAEVTWDRLARKDIDAPYVPPIRGGQGDASQYDRYPEETEQYGMAGEDPHGHLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI59</accession>
    <name>A0A370PI59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_276582</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI59"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="216"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="385" mass="43598" checksum="D572863D453FB94B" modified="2018-11-07" version="1">MVEHVLDDISHRRFNPLRGSYILVSPHRTKRPWQGQQESPSKTTLPTYDPACYLCPGNKRAQGDTNPKYEKTFVFVNDYSAVKEEQAPYSPEGGEDLESFFLKAEPVTGKCYVLTFSAAHNLTLADLSPAEIVPVIDAWTEIYTAHLSPKSPLAAVAPATTLPPNSPTASLTKPKEQYRYMQIFENKGAAMGCSNPHPHGQVWTTSSLPEEPAMELEQLKKYRRENGGKHMLEAYAALESRKQERVVFENDAFLVVCPWWAVWPFETMIVSKTHKRALVDLDSSEKVQLAEAIAEVTRRYDNLFETHFPYSMGIHQAPLDGTEEEIESSYLHLHFYPPLLRSATVRKFLVGYEMMGEPQRDITPEQAAARLRGCGGELYRKKMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI69</accession>
    <name>A0A370PI69_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="246" mass="26882" checksum="78D7741E562F7760" modified="2018-11-07" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSSLLEASSVEKIVEIDQHIGCAMSGLQADARSLVEHARVECQNHAFHYAEPLRVESCTQAICDLALRFGETGDDEESVMSRPFGVALLLAGIDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHRSLTLGEAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFRIYDDEEMGRAVAQLGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIG2</accession>
    <name>A0A370PIG2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIG2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="20405" checksum="D0C0B09997A0A0B2" modified="2018-11-07" version="1">MPTQPTPEKSKETLEAKSAFSATLLNIGGTHASPLVERAHTITENASALEKQQAELESHTAALAKQNESWDKLAGEARDGLKEIGDVQNWAEVVERELLVLEQTLQYVEGSDDRGHGDEIDDDDEDVNGGDGMNGSIITRNGTGKGKGSTNSTDSTSAVEDGGGTTTTTTTTTTTTTTTTGNGSGGSSWFKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PII8</accession>
    <name>A0A370PII8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_327352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PII8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000042">
        <property type="entry name" value="Putative exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="385" mass="41312" checksum="154878CDBF5891B0" modified="2018-11-07" version="1">MAAQRQASSASQTPLISPAELSYLYTSLSLPDGPIRPDGRSPTQFRPLTAETDILPGTNGSARVGFADGTQAIVGVKAEVEKTVVAAEALNLSQKTQEDYADNEGGEGQKTSSHGHGSWVQMSIEIPGFRDDDALPVFLSEMMREPLVESVAGGDGKGEDEMAGGLKGRLVINKRWHWRLYIDVLLLSQPLSYPLPLLSLTTHLALLSTKLPKLKSKGEEDPFFDDDWNAAEYLYPRSQSGPRLSSTKQVRPPVTLLVISVGDNVIFDPNREEITVADTVLAVSITQDSDSDGLKLLSIRTVDPPSRLTQPGVSNSENVATLGSTAAAEEAAMTDPSTGEEVAGVWRPRRGGVKRRTIAKMLKLVLQKGGVGEEVLEGLEGVQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ30</accession>
    <name>A0A370PJ30_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_21256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ30"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="17263" checksum="0CF322DD9B2836DC" modified="2018-11-07" version="1">MVIIIQNQPLLHVSGATSFCFSRLGLEQEETEMERSHLARQLTSACICTCRAMRGIRSRQVVQKRSLPNQSTMEMGCQPANTSGRRDQPSAGAVRISGAMHSTGPVCNSEAGRAHAGWWRHSFFRGGYITYRVLRLRWRALCDEPSVSVTLTAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJD9</accession>
    <name>A0A370PJD9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_14904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJD9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="164" mass="18185" checksum="6EA8B8FB563B9C14" modified="2018-11-07" version="1">MSTSTPIPISLNHPPDLQTRDDIIDALYRAVLGFDTTDTRLFDSALFPDSTFDLFGNVMKGLPAIHTECFDKISKLDTTHFLSNIRVSMVEGDPNKAKVTASTLAQHYRPGEGNVDDTSRLLGGAFYYCDVERDVAGDGLWKLRNWVIKLIWTEGDKGVMKGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJR7</accession>
    <name>A0A370PJR7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_335979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="30895" checksum="C57F533A4054E8BC" modified="2018-11-07" version="1">MTHREAPFIYVTLVPREKAALTESQQRITRSHAARSAHARVRHRRMIEYQAQKRGRRDIRDTVMGSYPGLPGRAPSGISTLLSADRRDPFLSFARGLNPIEQFLFDHYVNVVIPLMRCNESAIFFAQRMIRLWVPTAITESSLLDIILLAACRHLSIAYRQGSQGQQRIFQQLTFQYKSQSLHALRHAISAEMPMLTDSTVAKAIMLAYDELYVRDAKMLKHHVDAAVEMVTLKGGPQTLGLDGLMEHFLLNLITKTRGDLELSVRTPWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKU1</accession>
    <name>A0A370PKU1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_335548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000051">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF886">
        <property type="entry name" value="UPF0676 PROTEIN C1494.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="180"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="374" mass="40866" checksum="5071F3A5FDFEADE5" modified="2018-11-07" version="1">MSDVGPPIELPVLDISNPLDPEAGKALLAAATKYGFLYVDSRGTDFTTAEVDRAFELSKKFFASPVEEKAACRIEPNNRGWSGMHSETLDPEHQRTGDFKEAFNFGEFTNNNKAQQPLPASLIPHETEIAQFASLCNKTCTRILTLLALGLGIPPTFFTTRHDPTTGPTGSILRYLFYPSITSPLTSTYSHKTDVRAGAHSDYGSITLLFQRPGQPGLEILTPDGAGWAPVPVIPRSSSSSSTSLEGSEYPFPPILVNIGDLLSYWTDGLLKSTVHRVVFPVSEQQRPNAQDRYSIVYFCHPLDRTELVPVPSNVVEEFRRGKSKEGGDGGVRVGFGGGAGMLEEGKRALTAQEHLMARLDATYGFRREKEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKZ7</accession>
    <name>A0A370PKZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_315357</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000026">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000004">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001988">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="124"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="439"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="642"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="882"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1033"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1244"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1526" mass="173526" checksum="AFE65CA27FECA3AB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL65</accession>
    <name>A0A370PL65_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rpl16 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_265815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:negative regulation of translation"/>
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        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="60S ribosomal protein L16"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_uL13"/>
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        <property type="entry name" value="Ribosomal_uL13_CS"/>
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        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
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        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
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        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
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        <property type="entry name" value="Ribosomal protein L13"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="202" mass="23032" checksum="D74AC21CC17847EA" modified="2018-11-07" version="1">MSAIEPVVVIDGKGHLLGRLASTVAKQLLNGQKIVVVRCEALNISGEFFRAKLKYHAYLRKMTRFNPTRGGPFHFRAPSRIFYKAVRGMIPHKTARGAAAMERLKVFEGVPPPYDKKKRVVVPQALRVLRLRPGRKYCTVGRLSHEVGWKYQDVVARLEERRKVKSSAYYERKKAARRQLVHAQKSAGVNEQTKSQLAQYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLB1</accession>
    <name>A0A370PLB1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="27579" checksum="25115EE0AC711CE4" modified="2018-11-07" version="1" fragment="single">MTSASSPDEVPPRTSTPATAAADSEPEPEPQPEQDAVQPATTSATATAPAYSPIYATAEPSDLPPQTTGSLDTQVPLTPAATTTTITTTEDPPATSTSPPPPQPGAHPIPPPTSTDHPAPTSTTTTSNPSSSHPPPAPKPADPPTITPAPAPAPTASYTPSNPSYSYSYSYSYQPPNPATQPIPNSTTTPYGSLYQPPTTTTTTATTTVTSAGAQLPLHYEPDASSSGRVDLGEEEDGMWGWMKWAGRKLGEVEAEVWKKINEVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLP4</accession>
    <name>A0A370PLP4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_185612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000015">
        <property type="entry name" value="Nitrogen assimilation transcription factor nirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="700" mass="78591" checksum="65C182BC89056F7F" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMC5</accession>
    <name>A0A370PMC5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_250066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="47358" checksum="653854D7A4A07040" modified="2018-11-07" version="1">MYEPIEDVERMEYYRAGGYHPVTIGDRFHDRYRVVHKLGHGTYSTIWLARDEVSNRYVAVKFCTADSKPLENVVLSRLSQPQQSSGIDQDLIPTISDIFSIQGPNGSHTCLVTRPARMSLSDAKNVSWISLFHLEVGRAIVAQLMIAVQYIHSQGIVHGDLHRGNILLRLSRDFDELSTELLYEKYGEPILEPVNRLDGQEIPPEVPQHGVIPLWLGEASEDVTLPEAKVLVSDFGEAFCPSHEQKFESHTPLVVRPPEARFEPTQPLTFSSDTWTLACTMWDIMGQRTLFEGLLTNNDDMTSQQVELLGPLPSEWLTKWTEIRDKGSKSTHQLPTNSTHSWEDRFEKHMQQSRIREGMPPFEPRERDAFISMLRSMLRFRPEDRASAQQVLESEWMVKWALPEYEKIRNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMC8</accession>
    <name>A0A370PMC8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_232952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="235" mass="27262" checksum="69A1B403A296048B" modified="2018-11-07" version="1">MDEDYSAGSVDADREMTRLWRTWRTVFEMLLDRGYEVTEDEVQMPLHEFKQKYSDPLGYPDRNKMKISARPTEAMQAKYTPLPSKSNPNPQPDCGTIYVEFCPDSTGVGTKQVRTFNHFVDENNFHTGVFITQTPISPSAVRLLSSMPGRICEHFQEQDLLVNITRHELVPKHVLLSPDEKARLLERYRLKESQLPRIQVSDPVARYLGLRRGQVVKIIRRSETAGRYASYRWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMH1</accession>
    <name>A0A370PMH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_213263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="60518" checksum="F1C887E7BF0268A1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMJ2</accession>
    <name>A0A370PMJ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_326238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMJ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="40437" checksum="BBF7B88E3F799A37" modified="2018-11-07" version="1">MNWTVIPRDDSLPSMTITVRIIVLVLAIPTTFVCGLRLYLRKFVLNSWGLDDWMVMIALVSLPKCSSSGRRITEPQQVMVNGFSTLAFTITYYGLGKKTKDVPDADLLVWWKRLSYLLVAASVKTSLTVFIMRLFPTHSISIAGKSILGFLAVFTLAGTLALAFQCRPVRAGFDKTIPDAKCYSVNTSFAILMAQGVIMFVMDLAILALPLRRVWQLQMPRGRRVLVLGLFCLGFTACIAALFDEDIQLAYRYSPIKDTAATSLIWMELEFNLGLISGSLSSLRKLFQIRSPFKSRRTSSFTGSRSTNVELGSYKGWGGGISKQTEINRAFEILDSSQEHIAPIYGQGELCTTTNAFSNGKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN13</accession>
    <name>A0A370PN13_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_213661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN13"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="43054" checksum="4237B38D8358E151" modified="2018-11-07" version="1">MAEATLHNAPIVIDNGSGTIRAGFAGEEIPSCYFPSFVGRPKHPRVMAGGLEGDVFIGQRAQELRGLLKIRYPLEHGIVTDWDDMEKIWHYVYENELKTLPEEHPVLLTEPPLNPRKNRDAAAQIMFETFNVPALYTSIQAVLSLYASGRTTGVVLDSGDGVSHAVPVFEGFAIPNSIRRIDVAGRDVTEQLQLLLRKNGHVLHTSAEKEVVRMIKEKVCYVSLDPKREEKDWMNSYHKSETKSVDYALPDGHKIKIGQERYRAPEILFDPELIGLEYPGVHQIVQDAITRTDLDLRKSLYLNIVLSGGSTLCKNFPDRLMREIKRLAVEDMKIRISAPAERKYTTWIGGGILAGLSTFRKMWVSADEWHEDPEVIHRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNN8</accession>
    <name>A0A370PNN8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_275713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="199" mass="20103" checksum="8650DEFC1B714F17" modified="2018-11-07" version="1">MSFRGGRGGFGGRGGRGGFQQPLGPPAQVLEMGTVMHSCEGEMVCESINPKIPYFNAPIYLENKTPIGKVDEVLGPINQVYFTIKPQEGIVATSFKPGDKVYIGGDKLLPLEKFLPKPKPAPGAAKPKRAGGGARGGPMRGGRGGGRGGPMRGGRGGAPRGRGGPRGGGFRGGGGGGFGGGFSRGGGRGGPRGGGFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNT0</accession>
    <name>A0A370PNT0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_249202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479511" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="492" mass="52479" checksum="61D47C28E449B215" modified="2018-11-07" version="1">MVKTRWSSSATALSLLLNTFYAPTVSAIQTISAVGSKFFYEDGTQYYIKGIAYQLIPEDPLIDTAQCTRDAARMAELGTNAIRVYHVDPKANHDGCMKAFADAGIYLFVDLDTFDTAISQDDPHWDQSQFDSFKAVLDAFQKYDNTAGVFVGNEVLTTKDGSAAAPYVLAAARDIKSYRNAQHYRSIPVGYSAADIAELRPMLQNYLACRSDPAERLDFFSLNAYEWCGDSSYEQSGYESLQDQAAGYPIPIFFSETGCNVARPRTFSDQAAIFGDHMSGTWSGAMIYEWIEETNDYGLIEYGPPGADTPPTATKDLVVQDGFTRQGEPTPIQPDFDNLKNQWATLHPTGVALSDYVKSTAAISPPECPASTDGGWAVDPSAPLPTIGQAFVPADDDDKSSDSQRDGAASPASATATTTGTASESGADGSDSSNSSSGQQSSSSSSTGPSGVAAYSPSSGALSMHAGNGGFLFRLDISALICAVIGGVAWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP82</accession>
    <name>A0A370PP82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_213199</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="108"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="389"/>
            <end position="416"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="443"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="599"/>
            <end position="644"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="737"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022895"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43990.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="905" mass="94253" checksum="96B00C78D3F444F7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPC8</accession>
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        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">M752DRAFT_149502</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
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                <person name="Brandl J."/>
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                <person name="Gladden J.M."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 13157</strain>
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        <property type="entry name" value="Metalloproteinase_M10B"/>
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        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
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            <end position="789"/>
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        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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        <location>
            <begin position="21"/>
            <end position="39"/>
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        <location>
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            <end position="53"/>
        </location>
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        <location>
            <begin position="62"/>
            <end position="74"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51752"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44041.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="789" mass="86701" checksum="FAA690D39B09C4E8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPP7</accession>
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            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
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    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_275394</name>
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    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPP7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="408" mass="46055" checksum="6D17D81553667807" modified="2018-11-07" version="1">MSFHNMLNKLSGQPESYEKKSHYKFGRTLGAGTYGIVREADSSKGKVAIKIILKKNVRGNERMVYDELEMLQALDHPNIVHFVDWFESKDKFYIVTQLATGGELFDRICEYGKFTEKDASQTIRQVLGAVHYLHERNIVHRDLKPENLLYLGPDPHSPLVLADFGIAKMLDSPSEVLTSMAGSFGYAAPEVMLKQGHGKAVDMWSLGVITYTLLCGYSPFRSENLSDLIEECRSGKIIFHERYWRDVSQDAKDFILTLLQPDPAKRVTSEEALKHTWLTGESASDRDLLPEIRAYIARSRLRRGIEIIKLANRIEALKMQEDDEDIPSPVEMAEKASGTTPFPQLSPNGKSDSAPAEGEATGTKKRSLSKIARGAIFREVVLAKVREVKETEEREKVEREARERTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPU3</accession>
    <name>A0A370PPU3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_282365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="59112" checksum="17DF400452FC059E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ74</accession>
    <name>A0A370PQ74_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_282429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="4"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ74"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="10">
        <location>
            <begin position="461"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="10">
        <location>
            <begin position="618"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="888" mass="100883" checksum="05488584CCABA77E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQA2</accession>
    <name>A0A370PQA2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQA2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662138" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="210" mass="22593" checksum="8F3ADDBC95D803DD" modified="2018-11-07" version="1">MRLTTFLFTLIHLLALTSAAMTGNFMSMGSVYNTTQTTIQRLQQLAGHLVLDTSSLNLTGLNLTNLNLDLNLNLTQLTNWTGPVVDAAKPHIARAGNATKDYVVKHPYQTIFSIVGVFYPAGLLRLVGYGPLGPCARSLAAWSQTYWGNPVARSLRACLQSAAMNGYAAAPVLNTVRGVILSAGGYMAWKDGFGGKGEQEQEGGKEEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQD6</accession>
    <name>A0A370PQD6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_139604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="316" mass="35643" checksum="6EAF0E0F81E42C42" modified="2018-11-07" version="1">MRAATGTGHATSKDDDRKTSTNRLKNAEKSQNGKPKDDKSNRGREEFRKLINFYHQVIVDRLFDEDFDDLEKSPYLEASLQADRSGSTLLHSLVSQMGEEERVLSEEALDYIQRTVLENPRVFTSENNYNATPIIEAAKAHTYILFLVLDLLLSEPTRAELRSHPKSCDGDEICSLRDVDVPDAIRLHLSRQSNKQNECPPTPPPDSEPHVTGWVCPYLNVDIDQVLEEDQKLRDALIAALAPVGQSQKLFEGLITVRNFDITGKHIDLEAIKVLLDLIPEEVFLGQSTDDYTPVQRAVLLIDKESLDLTTLFGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRP4</accession>
    <name>A0A370PRP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_128431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="173"/>
            <end position="525"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="61231" checksum="74E7BF3853B707C0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRR0</accession>
    <name>A0A370PRR0_ASPPH</name>
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        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_247480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
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    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
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        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
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        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="53"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK44886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="477" mass="53613" checksum="17BB3253DE81AC97" modified="2018-11-07" version="1">MAIKSSILYENPSATAFVVDIPSSIAQAQALPGQDFPPSRPHPAPSASRSYHGGRVLLSSTPLREPYPSSTEPKTEAARARVLERIPLSERRYHSELIEPLVTEKLTELNAALENNNEWCLPRIIVDSDAQGSPGKRKRQRSIAACSCSCPNQDSGSTHSNRLSTRDDPPLILSPGDNAFSSISELSNTVVKNKSIEPATVKIRCQSTTEESNNDRTTTHNYHSFHIPPLSHFLRCTIPISDPIQENSHHHHHHQALIPGLPHEQKFNLILLDPPWTNRSVRRSGHYQTQFYKGWDLLTQRIRDILRGHLQYDNAFDREEGTADTKAPIAAIWITNSAKARKTAYEAIRGAGLEVCEEWIWLKTTMDGRPITEVGGLWRKPYEVLVIGGQVRESSEDGDVVRRVIAAVPDVHSRKPNLKELFERMFFSSLEGGCVPYSALEVFARNLTAGWWACGDEVLKFNSEEWWFDNTEEGKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRS3</accession>
    <name>A0A370PRS3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_333770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRS3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
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        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810488" description="Arylsulfotransferase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69532" checksum="3352B03A3C4B7C2F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRX0</accession>
    <name>A0A370PRX0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_247525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRX0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016845855" evidence="3">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="40432" checksum="3DF671391BC608E3" modified="2018-11-07" version="1">MAFTSLAGLVITTAIAVLSSGVGASAVGSLTTASTTSITPSPSPSPTMQTVPFHLAGPDPTDGDDTGECRLLGPFSLLVQAALGALALLSLVYKRWRERPQRPVKVWAFDVSKQVFGSAMLHLANLLMSMFSAGQLEIRSKYKPNPCSFYILNLGIDTTLGIPILIFILHLLNRLASYTPLANPPESIESGNYGSPPRASWWFKQSVIYFMGLLGMKICVFFLIQLLPFIVKVGDWALRWTEGNTAVQIIFVMLLFPVIMNAIQYYIIDTFIKKPIMLDTLEEAEHDTHEHRHALLAGMDEDASFESEDDSVGKDDGPETVKEDLVRFESAEYNPAQVEHSSAASARSGSSHGEYGDLSSSTKLTSQHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS62</accession>
    <name>A0A370PS62_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_274082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS62"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23535" checksum="10308849EAF1F45B" modified="2018-11-07" version="1">MTAPTPKSALAMMPTPNIPASEAVGHCQSVAIIDAPLQEVWDTLMDTSTWPSWNRFVPAVTIREQPGSDGGDLSPVLQTGTKMTYHVNMKPTSSSQPQRAQANNDTPLVVTEWDPPSESKKSGRIVWVLDAQAQGRIMSSLLAAERVHEFVEVDILDAQGQTRRGTEVRNWEAQNGALAYVVRWMVGAQLEVCFEAWLQDLKEYVEKKTTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSW8</accession>
    <name>A0A370PSW8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA34.5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33798" checksum="879F38FF6749A278" modified="2018-11-07" version="1">MAPKSNKKAVEEREPTPMSTSSAGDSSSSEVESNQSGSESDSDSSTSSNEKTSSQKTSRNVSLAAPQPYKAPSGFKSLKQQAPPKSNVSSLLSDLRGKQVYHITAPDYLPLSKVEEVSLAKIMQGKPVLKHKGVQYGIPVESFAQPDLGGKTLHLYDSKTKTYYSTAASNIPSYHIQEMLDIPEVSDETVAQAVQEQIKPPRKHPKHLKMRFRPVGSGVAPPETLGSSSEESEDETPTFKVPKSLEKERDERKRKNHPTEADGSQADAGDVPRKKSRKSAQEGGEGEDKKKKSSKSREEKKRKKSEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTI2</accession>
    <name>A0A370PTI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_282323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="36"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="712" mass="80382" checksum="62864277AE50C4E6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTJ0</accession>
    <name>A0A370PTJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_120089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="270" mass="31152" checksum="2088107D226ED3DE" modified="2018-11-07" version="1">MSANFPKFSLLPTELRLSIWQHSLPTPVHQGLYIYKRGCWEAHLVSEDRFHLSFNLSRLVTMRVDVPPFLVNHEAHSVAQNWLHQQAGTLLVHWTPDGFHFTRPFQPASDTLYVPDCRYLEFLVEGPDVAFAPQYEGLNYETSPPAFPRIAFSRSLLQREKNCITSVFDMIEYQDFEEVLVVEDMSEDDEGDLMVLPGVQRPWGWTVVPGTETLVWHNSARAYRREKGCEGDEADAFARLVEQASVGIGSWIGWEYDRLLKVKRVRAIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTL9</accession>
    <name>A0A370PTL9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_311648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTL9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016645494" evidence="1">
        <location>
            <begin position="24"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="406"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="755"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="856" mass="92504" checksum="9053C5B2992CFCB6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV15</accession>
    <name>A0A370PV15_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_332648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12762" checksum="23AB70AB4D8B3F1D" modified="2018-11-07" version="1">MSARPLSHCLRARCVPRRAQNIQGFSTRSNLRGDHYDPPTGYLFGLKPGQKYVKEGWENMWYYGFIGSLLVAGVAYVFKPDTSIQTWALEEARRRLEAEGILEDPDKVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVI3</accession>
    <name>A0A370PVI3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_228879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="30005" checksum="FA3D50AEFCB4B22A" modified="2018-11-07" version="1">MADAQFDSALDLLRRLNPRDTKQNLQAITSIVPDLTEDLLSSVDQPLEIRKCPKTDRDYLLCDYNRDGDSYRSPWSNEFDPPLEDGTVPSERVRKLEVAANEAFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVTPGAKSSGEWDSIHVFEATDRARMSHYKLTSTVILHLANETEALGEMDLSGNMTRQVEVDLPVESDASHVANVGRLVEDMELKMRNLLQEVYFGKAKDVVGELRSLPSLSESNRDRATHLEMIRSMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVL3</accession>
    <name>A0A370PVL3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_289762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="420" mass="47516" checksum="23608EF54E1DD3CE" modified="2018-11-07" version="1">MSSPSSPACSSSGAETMKELLDRGEVKASWRDKQFVHFLDLKEEYGREFLNLVKEHVEPNGFEWTDILTSENERRACAKDFVAQYGLKYWGTPANRKKYLQEESLADEKTLCTYPAQSEEIVRTIEILLLRKAKGYSRLSQEKAKSTQLTKSPFEAGNTSKRKSTLKETDEDTDKPVYKTRTRSTPSAIRPFKTIVCESEPEAEFQSSAAKKTKKQRTSLARCYTGTPEVQLPPSRGKDGMSAPHQGTFVHRAASQYAKNTKFPATEGSQSVIAAAQYAQDTKLLATENNHIGTTASQYFKDTKFLVTASNQVGMAPVWLPFTDFDQATEFLEHMAKQCNVMEWSPSEQLKWESMPPQVIAASVRFYWSDFEIRVRRERNEDLLLMLQELSNAWQAEDEGKEGASGSVYKIKVMLHIGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW37</accession>
    <name>A0A370PW37_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_324111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW37"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="376" mass="40923" checksum="E674A8D8B86DA53B" modified="2018-11-07" version="1">MTAVSSEYAHQTKGPRILAVFWTMTSLAILAVAARLFIRIKVLHNPGADDWLIATSMFFSISYSVVTTVDVALGYGKHAVVIADRLELVLLVNYINFALGIISFALPKLAVAALLSRFLNPTTIQRAILWGLTGFVALVSCICILVLFTMCDPAKALWDTSLLSKGASCRSSWILVDYAIFTGAISAFTDLYLAIYPTVILLKLHMSMRKRLALCAALGLSAVACAMAIIKCMQLPGLADLSDTTSNATADLVIWTSIESNVVILASCIPTLQPLLEIILGKRSLRSTGGYQYKESSTQLPESNKWSSKRSGHRKSKGNMMIADIGSQDSILQIGDDHEDESHYMGHIRRTDKITVVYESVTPQPGGADKTNDNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXP9</accession>
    <name>A0A370PXP9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_332231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="388" mass="44785" checksum="165B0535ECF7E7A8" modified="2018-11-07" version="1">MDKLTRNDPLGEFVCRFPNCDARYRRKEHLRRHEAKHIQDRTYPCSICGQEFGRNDTLRRHLRVKHQLNEPVHRARRACSNCRAIKARCEGKPVCTECQHRGIRCSLREAEDSPAPEPRPASVSPRPAVSREEQFVKMFFELFHPHWPFVHRGTFRIRHEIPMLVQSMVVLGLWASGERGARCAAVELHEQLNSAILQQKEKWDVSNEVPIPQAGSWPLPIYQAILLHVIFSLIYKTHGSLGIDLKPSGLRTDTELLLKCLIRSCRLRGMFYYPRILQQYQEPAIAQYMLVSIEEVKRFNIALYKVCTTIYGSTALSQMVEGASMGNILLTADELQFPLPENHELWDAGTQSEWDRALEGMSVDGLGEYREEEWISKQARMMHVLGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXQ6</accession>
    <name>A0A370PXQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_272742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000066">
        <property type="entry name" value="GTPase activating protein (Gyp5), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="361"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="728"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="863" mass="95364" checksum="019DA9F7374A73F4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXT1</accession>
    <name>A0A370PXT1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_281114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1235"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1290"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
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        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1382" mass="151828" checksum="5CE9002920C87AB4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN7</accession>
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    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000042">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118178" checksum="F360C5DCC25C2C6D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYR2</accession>
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        <submittedName>
            <fullName evidence="2">Cytoskeleton organization protein</fullName>
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        <name evidence="2" type="ORF">M752DRAFT_332556</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
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        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="943" mass="105926" checksum="85A496420D5DE13A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYS2</accession>
    <name>A0A370PYS2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_245662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002142">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="247"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="541" mass="60662" checksum="0B4AD7B84E5EBB1C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZH3</accession>
    <name>A0A370PZH3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10942">
        <property type="entry name" value="CE4_u11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="12"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="29956" checksum="094CF9141BA55A03" modified="2018-11-07" version="1">MPPSSWPDSAKAAVSITFDNVGESRDVGVGAWPKEKPVGQHPSVLEVTPIILDILDKHDVKVTYFMEAWGIQTYPKMLSEVQSRGHEIGYHAYQHEEWKTLSPLQEEEIINKSLPIAQELGVCYKGFRPPGGSMNAGTKDLLRRHGIKYASILGQDISTDKDGFVTLPFQWRAVDAFYILDAFDFLRAEYGEQRSIFTCEAFQQALFDQIDAAVEKGAFIDILFHPFLHTSPETRAVIEAVVARVSNDPDIWCAPTYEVAEWAAAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZJ0</accession>
    <name>A0A370PZJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_243833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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</entry>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="210" mass="22786" checksum="35068D6BE88CC677" modified="2018-11-07" version="1">MSSTIPTTSGTQPLDPYKAKSLDDDLPLAQKITDLSTFITEQKFGMLTTKSSEDDLLTSRCMALAGKERGDTTLIFHTNLFSHKTMDLTAHPTETNMSFLDPISGSWASISGTASIVADKETVKKYYSPALQAWLGDLGDGVHDGGPEDPRIGVIKLEAKTAVYAVSRKGVIGRAVETVKSVARGDVPAVNSIREVGRGEFDEWRRTHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZY8</accession>
    <name>A0A370PZY8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_261106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZY8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="602" mass="67329" checksum="7EADE23D3E081994" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0K0</accession>
    <name>A0A370Q0K0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_322908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0K0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="172" mass="18315" checksum="FFC1C4CBF5FD9ED3" modified="2018-11-07" version="1" fragment="single">MSFAARSLRPFASRVLSQKLPLSSVCRAAPASFPRGSVRSFSQSPLSQLKKYTESHEWIELAADGKTAKIGITEYAAKSLGDVVFVELPEVNLEVSAGEPVGAVESVKSASDVLSPVSGTVTQGNTVLDDNAKFINQSPEGDAWIAEIEVNDVAELDALLDEAAYKATIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0K1</accession>
    <name>A0A370Q0K1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0K1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="96" mass="10907" checksum="719D4491CF173D28" modified="2018-11-07" version="1">MVHKVLFWGGFGIAVRLWQLGIEMRPILAKESLWVYPLFAGVGGSFGYWLQGVENRQLRILAQRREAILEKRRRRDERESVGLSKPEEAGVLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0N8</accession>
    <name>A0A370Q0N8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_8737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0N8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="749" mass="82844" checksum="475FF3432474AB49" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0T6</accession>
    <name>A0A370Q0T6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_207286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0T6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017035237" description="SUN-domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33210" checksum="4064D808C2AB8903" modified="2018-11-07" version="1" fragment="single">MKATSATVAFLAIAAVQAAKHAHDHGHHRSPRSVDSPVVKKSSSCQFPSGAGLIPITPHETNGGWAMSPDQECKPGGYCPYACPAGQVSMQWDPEATSYTYPMSMNGGLYCDENGEIQKPFPDRPYCKDGTGVVSAKNKCKEQVSFCQTVLPGNEAMLIPTLVEELATLAVPDLSYWCETAAHFYINPPGYNTETACVWGTSENPYGNWSPYVAGANTDGDGNTYVKLGWNPIYLEPTTPFRNEVPEFGVEIECEGDGCNGLPCKIDPSVNGVNEMTGDSSVGAGGASFCVVTVPKGGKANVVVFDKDGGDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q124</accession>
    <name>A0A370Q124_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q124"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="180" mass="19804" checksum="90C439EEBDAAA30E" modified="2018-11-07" version="1">MKYATAEARQKAEMQPMLAEPSDIPFGARALEKGIQVEGIWTPDCHSARQSTTHSGSRPGSTASAPRPMLMTLTGGDIQGLERTYQPAPSPSIYDQCSSPKVLDIEHGQSEYISLSPTNQSLQLDGPISIGPEYSSDLDKRRSRWFGARSSWVKKPFDSYKRRSTPEGKVLKYNGLNLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1L3</accession>
    <name>A0A370Q1L3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1L3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123301" checksum="7BBFE0D8E26F9A1D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1P6</accession>
    <name>A0A370Q1P6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_14018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1P6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="37"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="346" mass="39288" checksum="86A758F33591B72A" modified="2018-11-07" version="1">MAAAANSSSTNPATVFPRSHVGFDSITSQIERKLLKRGFQFNVMCVGQTGLGKSTLINTIFASHLIDSKGRMTPNEPVRSTTEIQTVSHIIEENGVRLRLNIVDTPGYGDQVNNDRCWDPIVKYIKDQHSAYLRKELTAQRDRYIQDTRIHCCLFFIQPSGHALKPIDIVVLKKLSDVVNVVPVIAKADSLTLEERQAFKERIKEEFAFHNLKMYPYDNDELDDEERAVNVQIKDIIPFAVVGSERTIVVNGQQVRGRQNRWGVINVEDENHCEFVYLRNFLTRTHLQDLIETTSQIHYETFRAKQLLALKESSAAGSHPGSSRPISPSADRELSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3M8</accession>
    <name>A0A370P3M8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_260569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3M8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23188" checksum="48AC91EDECB80B11" modified="2018-11-07" version="1">MANCLAAPRRPLLALPFLLPSPYECVTLGLRRNQSSYRRTKQRLRVKPDASFGSSVSHSQEDHIIYNPPSSAPSVYHTPTKFLPSDDIRRNLRNASVKGSNAESLPLAVKVTTEKKYHLNPSDIREIRRLRATDPMTWSRLKLAKRFDCSPMFIAMVCEASPEKKEIQKRILEAVQSRWGSKRRMAREDRQLRKETWGRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3S8</accession>
    <name>A0A370P3S8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_280427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="7"/>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3S8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000259">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="25848" checksum="09764DB9FF6A0DB0" modified="2018-11-07" version="1">MAWYCSGSTNSELIANLFKTGLIKDERVKNAMLGVDRAHYAPSRPYSDSPQPIGHGATISAPHMHGHACEYLIDYLKPGSRVLDIGSGSGYLTHVLANLVVDPSSTSEADGQVIGVDHIPELVELAQTNMRKSKDGSNFLDSGRVKFITADGRLGWKEGAPYDAIHVGAAAHHLHPVLIEQLRAPGRMFIPVDAEDDEASFGLGGGQYIWVVDKSGDGSVRKEKVFQVSYVPLTDRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P426</accession>
    <name>A0A370P426_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_299084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P426"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="147" mass="16929" checksum="A5FE821E1AF362EF" modified="2018-11-07" version="1">MGYTHYYGVRDNHSTEWISAWPQLVQDAQRVVDATDIPLSGPTDDPRDDHVTPPLVNEVEGIDINGVARNSHEPLIIHLRDTKNFEFVKTARKPYDTVVGCILLRAHVLAPRQFCLSSDGYWDEMEWKLARNLYESLWPDRPLLSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4D5</accession>
    <name>A0A370P4D5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_280271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4D5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="125" mass="13760" checksum="1A2210FC9325599B" modified="2018-11-07" version="1">MAKSVRASVSKRNRAKLRATVFGPAVDARTERLSAKLQELASQPRPNEEKPSMELDNATTDNSGDKVTGNVLNSTGEMDIDQGTAKGGHTHTRKSGRIQKRHKKSRSSIVFRPHPSKVKGNSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4G5</accession>
    <name>A0A370P4G5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_340154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4G5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15581" checksum="706FB4309D671247" modified="2018-11-07" version="1">MVDSPVTRSHKTNEPDHSALQEGEIVAQESLPRYFAKSGPVDADPRKTKKDGGGKRNWGRSGDEVHDYGYNFTNTRRHSNSSAQGIADFKTKFEAVEPEPVFEENVHGPDALPPDDDMVRKLDSINSDNTEGSEVIWNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R5</accession>
    <name>A0A370P5R5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_242452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="61947" checksum="BFBB74AF54075391" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P662</accession>
    <name>A0A370P662_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_279633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P662"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="400" mass="43357" checksum="3E4227FDCB3032E7" modified="2018-11-07" version="1">MDFYTSPHNHTKNPGSAVSPTASATTSTREPKLQLPSTTDPPGPSNPPKPLVWLIFGATGHMGRSLVKTALSRNDLVSAVGRTFETSPAAMSKLEQEHPNKCLGLLCDVRARPTVQRVIDATIARFGRIDIIANCSGYGVIGACEDQDEYDIRDQFETNFTGTLNMIQLSLPHFRERGAGRYLIFSSTSGALGVPGLGPYCASKYAVEGLMESMLYEVDQFNIKTTLVEPGHMRRDDVGDLVGGVEESIFGGGGGYGAEEEQDSANNLALGSPLPLYGHFLVKPPSEPYNTPTSPAAHAKRMLMWLGDKQPASAVKAAHLVWQLGHCSYPPLRLILGTYAVESIRDRLKCIIEEIEDWKYLSFPTGEQQGHQQGHQQGQGKDKGPASVSGGREGDEMDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P672</accession>
    <name>A0A370P672_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_309129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="16"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="967"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2509"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="967"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2590" mass="283249" checksum="3AB08190AA68C56B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6C8</accession>
    <name>A0A370P6C8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6C8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="39030" checksum="13E47843B98ABB83" modified="2018-11-07" version="1">MAPALKAGHFQTHESPASGTIIIRDSLYGDHSITEPILVDLLQSPDLRRLIGICQHGVTGHLGLLPRQVKITRFEHSVGAFLLVRIAGGSVEEQVTALLHDISHTVLSHVVDWALSKPGEESYHEVHKARYIRTTQIPKILTKHGVPQTVLDEEQYPLVEMAAPHLCADRLDYALRDIVAFGILQLSDAHRVVASLKAFPDALSPNRMLVLGDPQAALDLARAYLVADREVWSNPTHVEMYRGTGQLIGNLVHEERIHEKVLWNTSDDQFWQLLKDIADPEGSEMLERFETKGLVEEDGLRLHKHAKVRTIDPDVCVSGTEAVALSVVNPDWAAEREDYIRKREATREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6F7</accession>
    <name>A0A370P6F7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_339733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6F7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="732" mass="82634" checksum="FAABE6A778EA8F87" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6S8</accession>
    <name>A0A370P6S8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_241529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6S8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="373" mass="42471" checksum="E18C53793058729E" modified="2018-11-07" version="1">MTSIAPSEKSVESSLQYWLIFLKFVVQKLELHKDVPDLSEDDREERRRLWWATYIIDRHAALSFNGRPRITDNECLSLPTPRPDPIWNQPGPLLPGSQGRSVHETVLSYHVGNLDMLGLFLPLSRILGEILEYRFLSDHSTFNTCHGLLNTVQKNILQNLEIWYHSFEALVGSEFCAIAEPDCDSFPAADIPTVAYYGFHMYHCMFVLLHGPMDVVRMYQDLTWQSSSDFLTAGEHAVACANIARHILRIDPQLSLMYRFFGTYFLQSSFIFLILAQKLGKRSDGLILRNCSINLQVLDMFVAATNMDYQRTFAKLLRRALSFNMAESTGDSVPGQDQPTPELTGVPQSPLDPEMLRYRWAPGYTGLWVGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P700</accession>
    <name>A0A370P700_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_241355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P700"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="375"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="527" mass="58031" checksum="7E761AF57CB0C490" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P762</accession>
    <name>A0A370P762_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_88830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P762"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="113" mass="12639" checksum="321C8FBB120E6837" modified="2018-11-07" version="1">MPPESVLQFYFALWLGVISRNPCNQVYLIDFLRNCPSLKDNPPSLSSCSADTRTNRLINDPASRLQMFSAVGRLVAEKVLRQMKGSIPSSMWSSVTLSRTYRTGQNLAQVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M9</accession>
    <name>A0A370P7M9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_297583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="139"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="292" mass="33025" checksum="E97885F4F82F9C5E" modified="2018-11-07" version="1">MLGARDSASYDFAFYRYDPSMGGAVLFILLFIGTTGYHVFQMVKSRTWFFIPFVIGVEIIGYIGRAMSSKQSPNWTLGPYIVQTLFLLLAPALLAASIYMLLGRIILVLQAESHALLKKKWLTKIFVTGDVLSFLLQGAGGGIQASGSLAGMKNGEHIIVVGLVIQIFFFAFFMVTATHFYLKVHKYPFPRSCSPHIPWKKHMKVLYATSIFIMVRSMFRLIEYIQGNNGYLLHHEAFLYIFDALLMFITMIIFNVVHPQEIGQLLRHPNDYSMATLPEDQAPNPYQGCNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8D0</accession>
    <name>A0A370P8D0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_78896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8D0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016787742" evidence="2">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="161" mass="18179" checksum="3AD168132140C0F1" modified="2018-11-07" version="1">MQEHFFFLPIFFLLLLLYLLQIVSAESNIKPIINTWMATKDDNKTGSGCLCVPMAREMTHQHLHLTFTYLLLSTCLSLCIWGNLHHLMFLFLCQTCPMCFVLSSPLIVFFYGTPVIVGSGGNERNVVGIPHTRMQCGCCRGRAIHSLAIFISLTCRCNSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8X5</accession>
    <name>A0A370P8X5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_221971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8X5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="269" mass="30766" checksum="6EE73EC0A7D4405E" modified="2018-11-07" version="1">MAARAVDFPLFSRLPAELRVQIWEETLPKFVRPLYFYRAGCWTLEDVGKKEVDVRFNHRLLSIDFEVPILSVNREAFRVTLSSMKSQGINAHVTVKKSIVFRRSFNPKLDTLFISEDQFREFFWEPVNVILSERGFENIAISCTEPAPMCLAVSRLIGETEDSFLSELFQHTFHRNTQKLVLVNNAGVLSNKRRASQQHWELNSALSTPKFVWNNAGDHFEGAEGISDSERKLLRGLNRGAADGMTDGLGWDKDHKLEVHLATAIKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Y3</accession>
    <name>A0A370P8Y3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_194706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Y3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19783" checksum="2A78FD1567AE6451" modified="2018-11-07" version="1" fragment="single">YSYSQSRRPYATQLCLTPLIYCVGDFSAQMIGDDDFDYRRSLRSILIGLVIAIPSREWFLFLGRRFNYSSSSLSLGVRVAVNQLLYTPLFNVYFFAFHGILSGEGIMGAVERVKNTVPTSIPRSFIYWPFVTAFNFTYVAPQSRSVATSVFAIFWQSYLSWLNNSAAKGTEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9G6</accession>
    <name>A0A370P9G6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_221568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9G6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="504" mass="56435" checksum="F8095EC612B11A52" modified="2018-11-07" version="1">MRHRLTKRACDECISRKVKCSGAWPCDTCQSAQKQVNCTYLKPARRRGPKVRRYIGGQGSEHATTGPLITPHVDPRDEGIARVEVEQHVLSTIPTEELVSVVRFYQQASYSVWPVVNAEVLLNKLEHGTPDIGTLCLAMALCAATMAQLQLAPTTVDSTMMAAECMRMREAHLDLRSVLVSFFLHVYHAKINQRDSAMRFIREAVYGARLLKLDEGVGEQETALGADVVANKEIVFLLLWVSERGYAMHLGLEPSYTSPIRLPDEVDVGDSADAKGLLELGRLFATFDGFSSGRSTNSRDKLVMTADSLAKTETVLSMLSFGKGDRPSTRIADYCITKEWMRTIIWQEALSRRLLSSKSGAQLMTFRFPAVVSRDLLMSLQGFNESDLLPLGRDQLLKCFEIANSLADTVLLTPSVSTYSAFQLGPHDFLHALYQKLLPFLEQDLMLKSILHSKTAEALLKAPARLLDLNYDPWSFDDDKDNAYTTEEHVDSPEQYVDSRWALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9J0</accession>
    <name>A0A370P9J0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_296866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9J0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="138" mass="14640" checksum="38A458A0A15041F8" modified="2018-11-07" version="1">MADAKEFTFQEVSAHNTKKDLYMVIHDKVYDCTSFVDEHPGGEEVLLDVGGQDGTEAFEDVGHSDEAREILDGLLVGKLKRMPGDPAPRSQPQSSSGPSGSGDSAGLGVGLYGIVLVGGLIAYFAYQYLQNASAAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9S0</accession>
    <name>A0A370P9S0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9S0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="133" mass="13842" checksum="5F473720ADDF664A" modified="2018-11-07" version="1">MTYGGWKPGKSDTPNPWAWNGGFPNSGSHNNFYWNNNTGNTTSTNCGNTTSENCGNTTTNYDNSRNMTTRADTATAYHYMNSNNRNIQTGNISANGGNATKGGDTGGRSGSGHSSSNTSDNVVGGSGGHISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC36</accession>
    <name>A0A370PC36_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_328908</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="782"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1527" mass="167933" checksum="6A43245F0A3DDE13" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCZ7</accession>
    <name>A0A370PCZ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_47632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="125" mass="13884" checksum="40D71A64BCFF0BFA" modified="2018-11-07" version="1">MDRDTQPLKTHLRRLVRKTFQEWLVAYTCLLACLGNFVPNWIDHAVSPRMTAPAERPKASSRLGDCFLVSVSWHQTPVLPLDPSCSTSLDPNSLPAMSGHHPTCPSYPATPPGRNYIKPRGTHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD18</accession>
    <name>A0A370PD18_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_328682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD18"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="28305" checksum="EFC8D74F3455A730" modified="2018-11-07" version="1">MTKFRPCIDLHSGQVKQIVGGTLSSVAADLKTNYVSKLPASHYAELYRKNDLRGGHVVMLGPGNDEAAKEALRTWPAGLQVAGGITDKNAKYWIDMGAEKVIITSFLFPEGKFSLERLQSVLAALDGDRSKLVLDLSCRKKGNTWFVAMNRWQTITEMEITQEAESIALLEPYCSEFLIHAADVEGLQQGVDEELVSKLSQWCTIPITYAGGARNLQDLEKVHVSSQGKVDLTIGSALDIFGGSGVTFDECIEWNKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD28</accession>
    <name>A0A370PD28_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_255110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD28"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001559">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="657" mass="71292" checksum="838D69CF9BC66648" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDI3</accession>
    <name>A0A370PDI3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="12623" checksum="72DEDDC82C90DFC0" modified="2018-11-07" version="1">MSPLSQMSRPLVRSSSNMRSFSIAVPARREGQVINPKPRGYLADKEPITRREATSERYFVRTQPTQPEQPETYQMVRQKMLEHRRHLDELDQYLQILGRKQGPTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDS5</accession>
    <name>A0A370PDS5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="21779" checksum="3E4E110F685CABF1" modified="2018-11-07" version="1">MPPTTSPHPNQRGIEPHPDLPHNAAHEVDYTPHPENSLPLPPSRQSIQDHIIALYCGSASAEDMSVYAEQAVYDDPFSYCDTRYKIAGQWYGIPKLFSKSENLGTEVVSNTEDEMVWKQRQKYTFRGIGASRTEDSLVSLRLQGGGGGDGDEERVVYHKDMWSERDYDHQGFGALMKKVNGDKLTGITRPPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDX5</accession>
    <name>A0A370PDX5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_254427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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            <begin position="24"/>
            <end position="785"/>
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            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
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            <begin position="284"/>
            <end position="770"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF07971"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40388.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="86937" checksum="E87F3DFB39148F06" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="767"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">ATCC 13157</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </feature>
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        <location>
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            <end position="268"/>
        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        </location>
    </feature>
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        <location>
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            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113847" checksum="16A42A63F5F56B4C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ6</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_35113</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 13157</strain>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802204" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="173" mass="18998" checksum="B0A08655A8008E07" modified="2018-11-07" version="1">MKFLASLALLASTVAASPMLYPRQSSNSTQSFYLKTSGASNDIHNNLYVYAYHTGAGFNDAVLTSDVGTASPAFLNGTHTQFDLGTSFPWGFKMGVQNNYAAWESVQINVGYGDDDFSIGTTGLEWSAQDGFGGWLVCDWYHNAPQLFYIYRYEEPTIPSSCSTVDLKPEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEP8</accession>
    <name>A0A370PEP8_ASPPH</name>
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        <submittedName>
            <fullName evidence="13">Phosphate:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_320051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:sodium ion transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="926"/>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="584"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115453" checksum="D7E9BB17FF6E250B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF12</accession>
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        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Simmons B.A."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01284">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="168"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="168" mass="18761" checksum="8AEB2151B34D16EA" modified="2018-11-07" version="1">MFSSTVARPLQLVTRFMQWASAVIVMGITSYFIHKGPRGQHTIYWEVISTMSVVFFLPAFISPFMPNALSKFVLIIDVIFSYLWLTAFIFAAQDYNWHNCGANSPPGLSCSKKKANEAFIFLTFIFTFFAIFLEVGALWAYRRESTPVREKNTGGAHGGPADAPVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFC7</accession>
    <name>A0A370PFC7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_277544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="33867" checksum="E5B72C71443368B5" modified="2018-11-07" version="1">MAITLLITGATGNQGGAVINALLAQDADVEILAVTRNPQSGTSQKLAGKSPKIKLVQGDLDHPSEIFENAKKLATRPISGVFSVQNPMAKGQNVDKEEVQGKALVDESIKQDIRHFVYSSVDRGGDASTDNPTNIPHFISKHRIEHHLFEQTKDGAMTWTVLRPVFFFENLVPSFIGKLSATAWDAYLQGKPLQCVAVSDIGVFAAKALLEPQNYKNQCISLAGDDLTFEHMQKLFKAKTGETMPTTYRVVCYVLMWMVTDLRLMFNWFYSHGYGADIQGLRKIHPGLKNFEAWLEEDSEWVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG98</accession>
    <name>A0A370PG98_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_253369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG98"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="350"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="807" mass="92206" checksum="1C018114DB7ED93A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGE1</accession>
    <name>A0A370PGE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_319927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="554" mass="61344" checksum="5FE03162601DF943" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGG9</accession>
    <name>A0A370PGG9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_236341</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016483876" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK41269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="537" mass="57198" checksum="4D8D4B7063D924C4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGV4</accession>
    <name>A0A370PGV4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_284613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="30"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="858"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="147509" checksum="42B6B7D705AD4BAE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHI2</accession>
    <name>A0A370PHI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_284395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120731" checksum="C39956204E4819F8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHV0</accession>
    <name>A0A370PHV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_276489</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHV0"/>
    <dbReference type="SMR" id="A0A370PHV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="247"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
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        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK41760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="616" mass="68571" checksum="EB2B33E4E8E7CE6E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJJ5</accession>
    <name>A0A370PJJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_234402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="ANK" evidence="3">
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            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="57"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="168"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="229" mass="24614" checksum="F12CCFDF89AA9424" modified="2018-11-07" version="1" fragment="single">QGKSLLSQAAKHGHVPIVKLLLARGNVEFDSCDQENRTPLSFAASAGHVSVIQILLETNKVRIDSRDNQGLTPLAWAAKNGHEKAVQSLLKNGAYIESEDDWGWTPLLCAAWYGKSTVVSCLLAEGADSEARDNNCGWTPLLCGAVNGHDDVVQQLLAKNVNLAAEDKDYGWTSLSWAAVNGHYEVVRQLLAKGANINTKDSHLGRTPLSLAAGNGHDKIVQLLVSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK19</accession>
    <name>A0A370PK19_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_276387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016722950" evidence="3">
        <location>
            <begin position="19"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="183"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="731" mass="79383" checksum="3B1E2FEFB7E814C5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK28</accession>
    <name>A0A370PK28_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_234624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26128">
        <property type="entry name" value="Gad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1527"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1816" mass="204684" checksum="F9EC43ED652D202C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKA8</accession>
    <name>A0A370PKA8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="366" mass="40390" checksum="6E3B04552FA1696D" modified="2018-11-07" version="1">MESSQTRPQSRPDFSVPASSSTVDVRVINTNTRLYLKPGVFWEPALRGFEGPHAPIYCFLISHGDRQIVFDLGVRTDWENYAPKVVQLVKATTVVSDCTRDVAAVLDEDESGLGIRTTDIEAIVWSHNHFDHTGDPSRFPPTTELVVGPGVAASSWPGYPSNPDGIVLDSDAAGRPVREISFESPNNHKPLRLGRFNAVDYFGDGSFYLLDAPGHAIGHLCGLARTTADPPTFVFMGADACHHPGVLRPSAYLPLPSSSAVAEKHHYGGCPGDLLMQIGKWQNSHEPFFQVARGPLFPDYPAAMETVTKIQELDAADNVLVLLAHDNSLHGRLPLFPDRVNDWKAQGLREDTRWLFCHELQHVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKC6</accession>
    <name>A0A370PKC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_19079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="36751" checksum="C7AFD4CD4BE728F8" modified="2018-11-07" version="1">MVRQRNLSNASSTSSLPESNQELESMYDYLAKVILLGPSGAGKSCVLHRFVKSEWRVLSSQTIGVEFSSKIVKLGAGPRRTRIKLQLWDTAGTERFRSVSRSYYRGAAGAILIYDITSHASFVSLPTFLMDARALASPNLSVLLAGNKSDLASDSVPPCDSLEDNARPPPTPSSTSSRMSFPFGSSGGSVRSNYDTTTRMTATHAPHGREVSTEETSHWAAKSNIPVAVEVSALTGEGVEELFNRLARIILTKIELGEIDPDDPQSGIQYGDGALYGHGTSDGSSIRSRISLDDGAVQLHRRQPRKNTTNNWKTGMREWEDVFRLSDPHQRRGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKE8</accession>
    <name>A0A370PKE8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKE8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="226" mass="24863" checksum="72A1ED52983E843F" modified="2018-11-07" version="1">MSLSSATGNLAGRPPKLANDLKSTVQQTQDTTTQTATRLPDSVLPGEYPGEPDHIHDAQRDDANSGPVLAPLQQWCRQSLPRLLDRFEAHLAWLLSWILPAPRQAWLYDEAARRPASTTFLVCQAICCGVPLLVFLAGVFVFAAVAIVLWAILSVLILGPVLLVASMMGVSLWGWGWLLYGLIKWIDQKYLGGLISRFWLSRMPSPEGQDQESAEGQDGTQEKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG4</accession>
    <name>A0A370PKG4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_318888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="47088" checksum="857B4A97BC15EB37" modified="2018-11-07" version="1">MVPKADVQVLIVGGGIAGLTLANICKKIGLSYKVLERTAEVTPVGAGISLAPNALRLLDQLGFMDIIRKEGQPLRKIQVYRNTTRWSLLDFEWLEPTYGYSMYSMPRHSMHRALYHRADPEHVILGAEVVGIEDEPNSPTVKVRLADGREFSGEVLVGADGIRSIVRRLLADKQGLAGVNTIRFTGRTHMTGISYPLEHLGPNDLGVATWVFYDDCILTSWPCTENRQWFVGVKSSEAKTTTRSTWKGATKEMINESYGHRFHPFGKNYTVRDVVDVAERVTASDVFEETAFPKMAHGRVALVGDSAHSMTSFIGQGACQAIEDVGELANVLHTYFAGQSGNPQVLRDLLTDFRKSREPRARNLVYYSSIFAQVHTGRLPYGLGPLARRLAFSYAPVWCWKWACNPLYGYQPRVHALDLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL87</accession>
    <name>A0A370PL87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_283515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="687" mass="75242" checksum="0DA0DD949074D184" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLC1</accession>
    <name>A0A370PLC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_165355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="428" mass="46214" checksum="A6328BD0C7C1AF8A" modified="2018-11-07" version="1">MARQKQAAPLQRATSSELMHVPSGDSQSPDKRIIGKSSVANGSASGKQAAQENAPETPGLMQLAICVLGIYASFLSWGVLQEAITTVSYPTHPPTAEVPEPPTERFTYSIVLNTIQSTFAAITGFLYLFFSTPSGQKIPSPFPTKKIVFPLLLVSISSSLASPFGYASLAHIDYLTFILAKSCKLLPVMFLHLTIFRKRYPLYKYGVVLLVTLGVATFTLHHPGTSKKVAASAAKGQSGSSTWGIFLLSINLLLDGLTNTTQDHVFSSPQLYTRFTGPQMMVAQNVLSTVLTSSYLLIMPHLSSTGILHNLLPFPIPPSTETELNSAIGFLSRHPEALKNVLGFAACGAIGQLFIFYTLSRFSSLLLVTVTVTRKMLTMLLSVFWFGHSLSAGQWLGVGLVFGGIGAEAIVQRQEKAAKERAKAAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN7</accession>
    <name>A0A370PLN7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_326821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLN7"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="44494" checksum="1335B4329157145D" modified="2018-11-07" version="1">MSTWGDYFRVTTYGESHCRSVGCIVDGCPPGMELTEDDIQPQMTRRRPGQSALTTPRNEKDRVEIQSGTEFGVTLGTPIGMMVRNEDQRPKDYGNSTMDLYPRPSHADLTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLRLSHGVEIVAFVSSVGNEHLFPPTPEHPTASTNPEYLNLLKTITRTTVDEFAPTRCPNADAAARMTKVIEQFRDNHDSIGGTVTCVIRNVPVGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFGGCEVPGSIHNDPFIVSDVPTQLGPNTTTKQRLTTKTNNSGGIQGGISNGADIYFRIAFKPPATIGQAQNTATYDFGEGILEAKGRHDPCVTPRAVPIVEAMSALVVMDALMAQYSRESAKSLLPPLPKTLPTRPTLGTNGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLR0</accession>
    <name>A0A370PLR0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_318975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000349">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="196"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="411"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="771"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="853" mass="98809" checksum="53216B3BC163546F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLR7</accession>
    <name>A0A370PLR7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_293292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLR7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12230:FF:000004">
        <property type="entry name" value="Methionyl-tRNA formyltransferase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="43940" checksum="9D4C6E81D21BCF94" modified="2018-11-07" version="1">MFLLRGPGALCVYRRAGLFPSLSRRCLATKAYEPLRILFCGSDDFSIASLKALHEEHVKRPDRIASIDVVCRPGKKVGRGLKQIREVPIKAAATNLSLPIHEIDTFRGWTPPMLPGGPINLIIAVSFGLFVPPRLLNGAKYGGLNVHPSLLPDFRGPAPLHHTLLAGRTKTGVTLQTLHLKHFDHGTILAQTPAPGFDIPNPDTCTVPDLLSLVCPKGADILVKGIREGLFVPPVEDAGWRASEADGQFVHAAKIKPEDRHIDWENWSSLDISRRNRVLGPLWSKALVANNASSEKPSFQHRRVIFTEFEEVTPLKGCDKFSVVPGLPFVDGAHPIDSTKWKGVYVFTRDGKLIKVHQMKVEGEPNADALRAALKARMVGDRTFYSGEVGYTPFYNPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMF0</accession>
    <name>A0A370PMF0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_314539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826807" description="cellulase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="410" mass="43414" checksum="F96A9EBB7146E2A1" modified="2018-11-07" version="1">MKTLSLAAVLLVQAWTANSSPRAKRSSAFQWFGSNESGAEFGSGNIPGTLGTDYIWPDATAIATLHSAGMNIFRVPFLTERLVPDELTGAADATYMADLKATVQTITDLGAYAVVDPHNFGRYYGNIITSTSDFAAFWTTVASEFTDNDLVIFDTNNEFHDEDQTLVLDLNQAAITAIRATGATTQYIFVEGNSYTGAWTWTTTNTNLVNLTDPNDHLIYEMHQYLDSDGSGTSSTCVSSTIGAERIADATTWLKENGKQAVLGEFAGGANSVCEEAVTGMLDAMVDASDVWLGGMWWSAGPWWGDYIFSLEPDDGIAYEYYLGVLEGYTPGSSSGSSGGSTTSAVASASSTSSAGSTTSKVTTTTAATATSTAVAAHYAQCGGEGWTGATTCADGYTCTVENEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PML5</accession>
    <name>A0A370PML5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_275630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PML5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="767" mass="86229" checksum="A21BA9D64A8C7E24" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN43</accession>
    <name>A0A370PN43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_314880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1654"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1688"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1732"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1796"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1917"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1957"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="639"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1286"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1286"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1975" mass="221509" checksum="831FBD0801982D7A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNL3</accession>
    <name>A0A370PNL3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_335301</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNL3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="74" mass="8738" checksum="BD85A80ECBA9126B" modified="2018-11-07" version="1">MAGPSKSLILDPALQKYYELNANRYKYFRWTPRHAWFSFLYMALIPGALGYVAYKTDGLYQLRGKRRGDTIVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV0</accession>
    <name>A0A370PNV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_212523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000050">
        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000036">
        <property type="entry name" value="GTPase-activating protein GYP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="923"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="292"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137564" checksum="ABFE3736F3860876" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP75</accession>
    <name>A0A370PP75_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_231882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="18618" checksum="B022B8D19CD5EA8C" modified="2018-11-07" version="1">MNPASMTTPMGGLGGGPGAAGPNMQGMSEQEQAMVKMMYSAMESCPMKTVMAGTMGFGLGGVFGLFMASMSYDSTFTPQGKAIADLPWKEQVRRGFKDMGQRSWSSAKNFGIVGALYSGTECCIEGLRAKNDLTNSVAAGCITGGILGAKAGPQAAAAGCAGFAAFSAAIDAYMRMPEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPC2</accession>
    <name>A0A370PPC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="253" mass="27779" checksum="C4E78EF50E2CCE13" modified="2018-11-07" version="1">MSGSAYDRHITIFSDSGRLYQVEYAFKAITSANITSLGVKGKNCAVVLSQKKVADKLIDPSSVSYIFRLSPSVGCVMTGSIADARASVDRARGEAAEFRYKYGYEMPCDVLAKRLGNINQVYTQRAYMRPLGVATTLVSVDSEKGPQLYKVDPAGYYIGYKATASGPKQQEAITYLEKKLKNKEYADGSWEDVVELGITALSNVLSVDFKKHELEIGIVGGPRADGQEGTDIGFRKLTEEEIDERLQAISEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ27</accession>
    <name>A0A370PQ27_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_137815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ27"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="67" mass="7872" checksum="8E7F3B7C00F8FEA2" modified="2018-11-07" version="1">MWMESSGELENLIVQDQHRHFFLRLAVCSVVIGLHGKRLCGTFDLQNTYALGNVQLPELWWIREGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ53</accession>
    <name>A0A370PQ53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_291495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="159" mass="17798" checksum="4A8D95FF5AAFBC1A" modified="2018-11-07" version="1">MAAIGINDSPFVLNHANHRDSIQYRHHPILPSNLRLGQDPRKQGKNVLASSAAKGIDALDRANFLRIFKCLWDISSPSTPQMKRSSTSSVISSYWEQATTNLSGMVAYCALEHACVRELIPVMQDPAYGQQPHYSEQWTHRTPPKATEDDLYGQDIGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQH1</accession>
    <name>A0A370PQH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_231368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="60683" checksum="28E6862D03AEC43C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQL5</accession>
    <name>A0A370PQL5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_140650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQL5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="90" mass="9748" checksum="43D50C5F49358B12" modified="2018-11-07" version="1">MERVASTGGYSMCLAAGSWLAPEPTSSDSDVVWGLQLPPTGGMNNVNSHPNELKRFGRKSEGNRKISSTCFFPTDFLQGLWHCTISASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR45</accession>
    <name>A0A370PR45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_248827</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1525"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1229"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1229"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2233" mass="256240" checksum="6BAB5DF7BBFA2411" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRI5</accession>
    <name>A0A370PRI5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_263632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="2">
        <location>
            <begin position="373"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="50287" checksum="D6F972C6A488527A" modified="2018-11-07" version="1">MSTATRNCAQDEADPIIHQACRIDETSPHSEWTQTQLLPLLRSHLPHSLPLLRRIQHEIAHPSPTAVILTTFPGPAPAPPASSSASPPVSPSASGEDRLPVPELVSNPGLLPVPGPRVPDPSPPLAPDTAVPAAASDPSSFFLLLPWMIAYVDLSAGRENQVIVYSSLERTASIPYTSTSPEPSSSSSSSPEDTPGSYSNSNSNTIPITTISSQHHPILRTQLLSLLHHIKQHLLPPYLTTLSQLPSTQTQPQDHQLPPPPPTAFLFGNLHTGLFSTLLNSNTSYSLAQPTSPADFIPGIKVHRFSQPPYVKYLLPREVICHQPRDKEEGNLPPGFHFSDGCIPREKLGLVRSRTVIPRSEETLAKLRSCAVYRDGSEEPVAWAFLGTDGTLATLHVEEEVRGLGLAGIVGREVMRRGIEEDVSLNDGWMHSNAAEDNLASRRVMEKLGGRVGWTVCWCVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRL8</accession>
    <name>A0A370PRL8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_247362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056300">
        <property type="entry name" value="SusG-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23915">
        <property type="entry name" value="SusG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="68874" checksum="AD1335C47B1EBD86" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRY5</accession>
    <name>A0A370PRY5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_247590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRY5"/>
    <dbReference type="SMR" id="A0A370PRY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="450" mass="48253" checksum="ABAFA65D3699D1E6" modified="2018-11-07" version="1">MATQKAAQWAASLTYSSLPPDALQAAIRSFYNWVGCTVGGSNHPAASIARNSLSRFFGSPTSTLLGTNGLQADAQHAALINGIASHVHDYDDTHLETIIHPTGPVAAALLSFAQSLDRPVSGQDFLAALAAGIELECKAGLAVWPSHYDVGWHITSTTGSIGAAVAVSRLLGLSPEKTAHAIGIAATQVTGLREMFGSHTKSFHPGRAAQNGLLAAILAADGYTSSLQALEAKRGWVNVVSNDDKLTQEIDSLESDGKWELAKNAFKPFPCGIVIHPVIDGCVWLHGELQRRGLRLQDIKSVHVTVHPLVLELTGKTKPKDGLEAKFSVYHGGAIGLIHGKATPAEYEDNVVTNPETIEVRDKFVAIAADNIRADECRILVEFEAPEVKIEKHVHHAVGSIDAPMTDSQLTEKFIGQCSPILGPQQAKIISDWCWSLETKDDVRQIGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS56</accession>
    <name>A0A370PS56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_291097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="177"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="40739" checksum="6C72D1AB3F94A4D4" modified="2018-11-07" version="1">MAPSNKQKRGHPKSKPSSSKRRKTAKAGPEAPGQSEEADPQSTIPSQAQPASPVHSSSSDLSYKIYDGLDRYGDLEPSGIIVDVELPADIKEYADITVLSISRLRNAEQGGIESFQEQIAEVNSRRSMHHEWVGLIHKAILRLKLENSISFTTVEDKDWHADIQPKLLQSPEYISRPDICVGLRELQIREVLYHKSDDAVAEEFWNKLKIDGGVISDPFAKPQYLRFPFFIVEVRSDTAGDDLRQAQNRAAVGASRALWMLQMLSANRREAKSAKPKKSFDITNLPVFSLVSDGATFQLWVHYRNLIPGESADKMEYCSAHLKSWHATSEKACSKILKSIYAILRWGVGEYKIKVAEALKSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSA4</accession>
    <name>A0A370PSA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metalloreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_247349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="270"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="644" mass="71647" checksum="07D18F06A654BA32" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSC7</accession>
    <name>A0A370PSC7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:flavin oxidoreductase/NADH oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSC7"/>
    <dbReference type="SMR" id="A0A370PSC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="369" mass="40925" checksum="850FE74BB75D0489" modified="2018-11-07" version="1">MSKLFSPIQVGRMPLAHRLAMAPMTRFRVDDNHVPLDLVTQHYEQRAAVPGTLLITEATIIAPPAGGFPNVPGIWNDAQIAQWRKVTDAVHKKGSYIYMQLWALGRVASPEFLKANGNYDVVSSSAVAFDNGPVPRELTEAEIHEYIANYVQAAKNAIAAGFDGVEIHSANGYLIDQFIQDTVNKRTDAWGGSVEKRSRFALEIIRAVSDAIGADRTGVRYSPFSTFQGMRMDDRIAQFTHLAEKTAEFKLAYVHLVEPRIAGNAEGLVSDQDSLDFFVKAYGDASPLIVAGGYKADSAKEAADVQYKEHEILVGIGRPWTANPDLPFKIQNNVPLRPYEREVFYLPKDPKGYIDYDFSEEFKTVQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSM1</accession>
    <name>A0A370PSM1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35853" checksum="F1835E122E9B06C1" modified="2018-11-07" version="1">MGWFWGGSNKDDPVKKLDPGLREYLEHEAPEKYVPTTSVPSSQDPSKTVPQDAKPSVSAEPSEPALPSASLFQDGRYAHLWKTYKPPQEKEATEQKTAERVIEKYKQRGDTVHRAAMENCALEHEDLTYCFQTGNWEKRLRARVTLCSEENAKFSRCFTTQAKFLQALGYASSFNWDEEREERIQMHADKLYHQMLDYEKRAEEARKAGQEPPPLTSLFNPQAEAQQTPANAPGALEIPGGETIPTGLKPSKPLAQLTPHERELEIRAHNAQLEQQKLYVQEASPFMQTHEDARQKRREKAVSWFGETIGRWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSY2</accession>
    <name>A0A370PSY2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_134657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="316" mass="35587" checksum="0793197D02FE567B" modified="2018-11-07" version="1">MPREYAPSHRKRKSHDISDDADAAAAPGAGAGPRKKILLPKKEHKYPSVNELKKRIRDVKRLLNKADLPADARIVQERALSGYEKELEDELKRRDRSKMIKKYHFVRFLDRKTATKDVNRLVRREKEVSSAGPDAMDTKTKEKKLASLAEKLRVARVNLNYTIYYPLDEKYIALYAEQKKKVKGDGAEDGGDGADSDGDARFGMVHATVADKPAMWHVVEKCMKDGTLDMLRDGKLESGAKAGEKDRKKEERSQRAGDKAKKSQERGVSSSQAGKSRDRSRKVDDRKRSRGPAEDHVMRDAGNDDGDESDGGFFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSY8</accession>
    <name>A0A370PSY8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12474" checksum="60101B535681CE08" modified="2018-11-07" version="1">MPPPPPSKPHPLTPTPTNYLTFDTWNSSSTGHQVADPGSSRGITSWRETRREKLTRQFGVGRGDCTYDSDNGVIDKGEWVLTQEESISAEMQKKSMEGRKQQQRDIRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT57</accession>
    <name>A0A370PT57_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_273693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="32283" checksum="5FF6F50E2892A529" modified="2018-11-07" version="1">MSLFSYVASGISSFVVFTLSLFALGQKVPRAAFVARCLAAYGSLLLCATYGVLASIVLRIAGYGRISQWATARSFKWVMRYTTGVRFNIVEGAEHLNTRPAVFIGNHQSELDVLMLGYIFPPYCSVTAKKSLKHIPFLGWFMALSRTVFIDRANRETAVKAFDSAADEMRNHRQSVFIFAEGTRSYSDTPELLPFKKGAFHLALKAGVPIVPVVTENYSHVLSPRNMRFEPGTIKIKVLPPISTEGLTTADIDALTKSTRESMLKTLLELAEKNDQEVESTVAANGKSTAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT93</accession>
    <name>A0A370PT93_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT93"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF522">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="193"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="438" mass="49251" checksum="24230FF8DF7914F6" modified="2018-11-07" version="1">MEKLRNGPERLPIHRIPMQAQTNLTSRITPIPRNRTLSLGSCNYSPSQKSMGDLDYTLPTYIKEIHHMKLSTTIYLSKPKDRHPYPSYPEKIEKWQAEETAFKKYWNIISELVVQEASIIACTHNLTGTIIIKSNFDKDKQALEPDVLIPLITPNKQKLILGTIRGGDQQQLPPLSITASEVPGYNEFGYQMGRSLFDRLRRSQFPFTLVSEQHRMHPRLSRFPSEFTYNGRMTNDPVVHSVSVGPELSGMELIGIDVTDGKAVVNGKTRSRSNIANVTVVMELVEFLISRDALKGRTSAIITTYADQRKEYVRSLKKLSERLSIAWKDMIKIATVDSMQGHEVDLAILDWVVDSGAKSHLGFASDNRRTNVALTRARACLIVVANGAILNNDRLSERKPTHLHPEVLAHWNSLFLNGLVVDVRAGLMTSNADGQGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTT7</accession>
    <name>A0A370PTT7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_246794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="676" mass="75702" checksum="A5FFAC961A71ECE8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU30</accession>
    <name>A0A370PU30_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_311778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU30"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="644" mass="73899" checksum="3D17B1ED868CC51E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU92</accession>
    <name>A0A370PU92_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF453-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_290360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU92"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="175" mass="18484" checksum="8C153035E632032A" modified="2018-11-07" version="1">MPKSSQYSLPATYYRGGTSKALFFREDVLPGPGPQRDRLLKRAMGSPDPLQLDGMGGSKAVTSKIAIVRPSTRSDADIDFTFAQVGVAGDFIHYSANCGNISAAVGPFAIEEGLVQFRPGRSVDTTVKTQEVRIYNTGTRKLLSAHVPVSESGAFEPEGTHGIAGAPGKTIGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUJ6</accession>
    <name>A0A370PUJ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_281923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="29477" checksum="24B433F36130C362" modified="2018-11-07" version="1">MVPWVKPGAAWLRSRRRPSAKRSVKSGQLSATKPYGHGELHCHKWMKKRTYFDPLLFSTGLASALNRRRQAEIVSTRSYPTTQNHAFSASSCGLWIERNIIEEAERRGTLNPGMTVVEATGGSAGSYLAFICSAKGYRFRVVSCRYGYGSISRSEVYVPDTRVVVLEPASSPVITEGRTGSHSVEGIGNGFVPPHLDSKLYDEARGISERESRAMCRRLAREEGLLVGTSTGLNVVAAIALAKELGPGKTVVTVAVDTGLRYMNGNLLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV3</accession>
    <name>A0A370PUV3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">M752DRAFT_262304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="547" mass="57845" checksum="649E6B1F48A8FE52" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV94</accession>
    <name>A0A370PV94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_228777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="854" mass="93268" checksum="26270F28D9231EE1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVX9</accession>
    <name>A0A370PVX9_ASPPH</name>
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        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">M752DRAFT_273157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="833" mass="94830" checksum="4AD3A083302BCC8B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW21</accession>
    <name>A0A370PW21_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RNA polymerase I-specific transcription initiation factor Rrn7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_102009</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
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    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="12">
        <location>
            <begin position="80"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="13">
        <location>
            <begin position="222"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="542" mass="62418" checksum="FE0A4A3988AAA35C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWC1</accession>
    <name>A0A370PWC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_333050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="83" mass="9222" checksum="7642241608380CFF" modified="2018-11-07" version="1">MSASESKGTQGFYDELKALFQQADKSGEGKLALPEFKAAVKGSSSGSQLNDMQLEAMFNFYDEDKTGFVSFESVWKKMNSMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM2</accession>
    <name>A0A370PWM2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="227" mass="25226" checksum="5A378D677B9936D4" modified="2018-11-07" version="1">MTIPHYGVWVAQPTRYTAQTEEEDPKSPHIYLYFKDDSSSSKDYEAAINVKSTGKDSRLVYWFDRSFSHPITEQLSNLDEGFHLLKSYSHRSRRHQESSSKLKGLDFLRTKGLVNIESGAVLSEADTGPHNAVLEALEPILNDAISKKATVYIFGSSYGSGIHDVHMNQGSAPSYENGIYEDGALLFSFEDGHWEAVFLAFASQEIPTDDKGEPEEGSKSLASILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM6</accession>
    <name>A0A370PWM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADPH-dependent FMN reductase Lot6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_317452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="83463" checksum="8799B31B7CF37618" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWN8</accession>
    <name>A0A370PWN8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF914 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_104353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="400" mass="45549" checksum="04C0D6DF4437FF34" modified="2018-11-07" version="1">MSADNEKSAAVADVQPQPEYSTEKTEQVHTVTETSEQTSQPHDQEAQQEQQPTQGRAARLFAYMKTRDFWLVLILGQIIALADISSSTFSTLLSNAGNSIPAFQTLWIYILLNLVYTSITLYKYGFKKWFQMLYRDCWRYFILAFLDVEGNYFMVLAYRYTSLLSAELFSFWTIICVAIISFIFLRVRYHITQYLGIFLACGGLGMLIASDYLRGANYPAEDQVKGDLFALLACTIYAFSNLFEEFMVSKRPMYEVVGQMGFWGMFINGVQCAIFDRSSFHGATWDKKVGGYIAGYTIVLFIFYTLAPIMLRVSSAMFFNISLLTMNFWGLIIGIQVFHYSVQFLYPIAFVLIVIGLFVYFIMEGEMGEAKKPWLGKDQERGVDGVGTGRRAQQTGHAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL6</accession>
    <name>A0A370PXL6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_289047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="142" mass="15611" checksum="B49BAECB56985554" modified="2018-11-07" version="1">MYYILYLASLCRRRHWAEPAYESYAVGGGYTCIVRVNNREYQTEDVCESKTLAEENAAMRAYLICRNFSVNDGMYPAGHEHRGGPIQGIPVAIGTGRKGRYGDETDMSTSGESRSGGSSPESCEGRLDRRGVGPTRALAFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY92</accession>
    <name>A0A370PY92_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_272909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY92"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="17810" checksum="E67EA409FB379BA4" modified="2018-11-07" version="1">MSKPFDPETAENFEDMEKQFAVKAVEHLMTYWSILEKVPGSQLRLTKMDDDILESFQKEFPDFDPAETLNEDKMKSKEGKEKWRNWINQYEKIIEDFNFGTMLRASPNVEYDRDTTIFAMRMQFYAIEIARNRAGLNDWIYERAQKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN6</accession>
    <name>A0A370PYN6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_245618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="22658" checksum="AA2F4EB93A8AF967" modified="2018-11-07" version="1">MEVLLGITGKDFVILAASKAAMRGPTILKAEDDKTKQLNEHNLMAFSGEAGDTVQFAEYIQANIQLYTMRNDTELGPSAVASFVRGEMARSLRSRNPYTVNLLLGGVDPITQKPHLYWIDYLASLAPVPYAAHGYAQYYCLSTLDKHHHPDISLEEGMKLLEMCTDELKRRLPIDYKGVLVKIVTKDGVQEVPFDNDRIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ68</accession>
    <name>A0A370PZ68_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_206792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ68"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="58447" checksum="990FD27A8EC31428" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZC3</accession>
    <name>A0A370PZC3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_331375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZC3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32771" checksum="3F5AB86DC5C01E14" modified="2018-11-07" version="1">MTVSKSNLQSSVGVGRDIATTLNYIIPPGRDGLKAIDAGIPDAERRNAKREGITDVRDVVIKDIRGREQEFTLDVQGFQYVKHEITGVTNWHDPAQIKQIIQPATEELVKRLTGASEVVVYLTRTRFEGNKNGEQMSTMNSPSHGVHSDMTQASCRTVLKDVLSEDEIERLLSYPYVVVNAWRPIDTVRRDPLALCDWRSVDPASDIVPDRRIVSGDVVEFGLPVYNEKHDWYYLSEQQPDEPLIFKQLGSDVASSVTLLHSAFVDPEHINGPPRESIEMKCFAFFTERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZT5</accession>
    <name>A0A370PZT5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_322687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZT5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112265" checksum="6A5E4A95E9303593" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q000</accession>
    <name>A0A370Q000_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HRQ family protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_299671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q000"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="47958" checksum="55BC68638B9A2EAF" modified="2018-11-07" version="1">MFPKSFEFGQSPIYDIALISAVTSIGVWLITRAFHWWTATSKPGVSRSSTPDLEKKSVAVTRKPGEWIPSDFRRPPASPYPDWDVHTTKPIPYRPFRYGPKYFVTMGLRSLKWDEWIELDNHYLKYHADKARRIAERGDKCCKTAPEAWDAAIELLEELTSYLPERYPTMFQKTPTGLTNLITHETFDITQRPLPEDPMTIAARLIQDDLAIMIERPDGEYYLLAGAVLLAGFWRLSDKYGMRLSEIHTSGSVPQYTEKLEKGMMNFFRRLKPEDPVVRNNYFIQVDDSLPWSHSIGFEDSEAVSWSTAQKNKAIENHWFRSERQSLRRLPKTGGVVFTIRTYFQPITGIVEEEYVPGRLASAVRSWGNDVAVYKGRERYGDVLLEFLDRKHQEQVDRGLRVELEDEVRKYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q097</accession>
    <name>A0A370Q097_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall biogenesis protein Mhp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_6909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q097"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="924"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132140" checksum="21FB8DE56103C51C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0E1</accession>
    <name>A0A370Q0E1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_261238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0E1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="11581" checksum="5CC69333466154BC" modified="2018-11-07" version="1">MASSREPGLFTAFRDSLVTKQVVSSTMGAAPAPIAEHPTPNRWRPSLVLQAPALPGPSTRLAMALDSCKAAPIIVCRIPSCVKRQLKTATCDCGKIWFTMFGNSRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0I7</accession>
    <name>A0A370Q0I7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0I7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="45318" checksum="1DFDF8D08ED3520C" modified="2018-11-07" version="1">MEIIKLPRKQRAQERPRVWPPELLNHIEHCLGLPVRQALSIIDWKDFFSSVKWEANRYRDNNCTPGQLLEMSIYEKAAHQYRIGFCDLEEPTCIFEPTHPGGVVDQIKNGDVQGLKRRLDEGLDADGYNLAGIPLLSLAVVHMQPGCVELLLTYCASPKTRGYWLVAEPLDYVMPAPLSDSFGHQDAIIRMLINAGSSFSYFNVLDSIFLSDSLDLLRKVVQQPPGLFANWPNSGYEMILLRVARYGKGCVEIADLIVTMVPEVLEVKTTLGDTALHVALFNSEAESMVKNLLRFRIDLLALNATNVSALAIAVRKGLVGAVEAMLSRQYIDLLQLHEVIPFSETPLGQAIETRNEYLMHLLLTDRCMCLTERAQNAALDLARVWGYEGSWVALIQNLQIWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Q1</accession>
    <name>A0A370Q0Q1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_322941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Q1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="44386" checksum="37A1ABC8A264A4E3" modified="2018-11-07" version="1">MPPPPPPPPPPGGMGGPPPPPPPAGNLPSRPSGSAAKGRGALLSDIHKGAKLKKTVTNDRSAPMVSGGGAKSSGPAIPSAPPVPGMAKPPTGLAPPVPPAQAANRLRSNSDTGSGGDAVAGAPAAPQLGGLFAGGMPKLRSRGGVDTGANRDSPYRSDTDGSRSAPPPPAMSAPKPPGARPPPRPPATESPPTPPVNPLVANLRKPPPRPASRPSSTVSTASSRSAPDAPPRAPPPLPGSAKGPPPPPVSTRKPSAPAPPPPPPPSASPAAPPPPPPPASAPRPPPAPSRSTPPPPPPPGASAPQPPNGTAAASIAVQAARNALGHAPPPPPPAASAPAAPPPPPPSAPPVAPPSEPLSRPSPLPSAIAPPPPHQPDRSTLDPSAYTLSNGGPSPGTSPRSPGGHGIMRVDDHRFKFQSEGLLPKPRPFVGGTRRYRAGRGSSVPLDLSALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0R0</accession>
    <name>A0A370Q0R0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_271976</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0R0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="452"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="691" mass="76756" checksum="EC072428BB3CF5F8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Y1</accession>
    <name>A0A370Q0Y1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_272287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Y1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK48093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="51620" checksum="2075A948106AFCB0" modified="2018-11-07" version="1">MSAVRPVRKGLHLLGSSSLARPASVAVNGASLLPRQLAASPRALRPAASSIPTARALPRVTSLSAQGGVRYASSVAPSGPVKKTQLYDLHLARGAKMVPFAGFSMPLQYSDLSHVESHKWTREKASLFDVSHMVQHQLSGPGALDLLMKVTPSSLDKLKHNQSTLSCLLEEGTGGIIDDTVITRRTDDTFYFVTNAGRRTEDLAFLQAEIDTYKQAHGPDSLKWEILEDRALVALQGPKAASVLQSLVTPDGANSDLSTLYFGNCRELHLTFPDGTTTPQPLLVSRTGYTGEDGFEISIPTASDATLPVRVTELFLSNPDEVRLAGLAARDSLRLEAGMCLYGSDISTSQTPPGASLTWLVGKERRDPATANFNGASTILPQVASPKTLSQRRVGFTVEKGSPAREGAIIVDLNDESRTQIGVITSGLPSPTLGGTNIAMGYIKNGLHKKGTEVGVLVRNKLRKATVTGMPWVESKFYRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q252</accession>
    <name>A0A370Q252_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">2-oxodicarboxylate carrier 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_331916</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q252"/>
    <dbReference type="SMR" id="A0A370Q252"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="305" mass="33292" checksum="FB620C51188CB890" modified="2018-11-07" version="1">MSNNNTQKPLPFGYQFIAGAVAGVSEILVMYPLDVVKTRVQLQKGTAVAGEEYYNGMFDCLRKIVKNEGFSRLYRGISAPILMEAPKRATKFAANDSWGAFYRNLFGAEKQTQSLAILTGATAGATESFVVVPFELVKIRLQDRASAGKYNGMLDVVKKIVAAEGPLAMYNGLESTLWRHILWNSGYFGCIFQVRAQLPAAEPGNKSQQTRNDLIAGTIGGTAGTILNTPMDVVKSRIQNTSKVPGQVPKYNWAWPAVGTVMKEEGFAALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRNMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3P1</accession>
    <name>A0A370P3P1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_287819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851882">
        <property type="protein sequence ID" value="RDK36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3P1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="114" mass="13337" checksum="3DB185464EED3829" modified="2018-11-07" version="1">MAPSQDGRYLPGIKWKSSPGTFWKVFRLAYERKTSNKITKQMNCQMRCTTVSTTKKKFGHGSCRPHNHRPQAILNSRYRHIQVSLLRDPEGEPHRINPEFTFEYTKEWLGAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Q3</accession>
    <name>A0A370P3Q3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_226209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Q3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="479" mass="52458" checksum="DED76E486D35DD72" modified="2018-11-07" version="1">MGFLHFLKTRSGFRVDNSRTTSAATLTLRQSLWPLTLVTILFFLWGFAYGLLDTLNKHFQNTLHITRTRSSGLQAAYFGAYPLASLGYANYILRHFGYKTVFIFGLTLYGIGALCMWPAGLNRSFGGFCAATFVIGSGLGSLETAANPYLTVCGPPKYAEIRINLAQAFNGIGTCVAPALASYVFFTSTEDDVNALKRVQWVYLAIGIFVFVLAGVFFVSTIPEVTDEDMAFQVAETHVGEEDKPFWKQYRLFHATLAQFTYTGAQVAIAGYFINYVVETWPGTTSATGSKYLAGAQGAFAMGRFLGAIIMRFVKARWVFLAYLSLTVAFIAASITQRDQKGIAMLFLTLFFESVCFPTIVALGIRGLGRHYKRGSGFIVGGVSGGAVVPPILGHVADMRNSTGFAMIVPTMFMVVAWTYALAVNFVPAYRDMVDKVGESEIGLRDETSVSPKDVESGDGLADMEKEKGEETARVEYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P415</accession>
    <name>A0A370P415_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_280282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P415"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="715"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="529"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK36602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="802" mass="89101" checksum="C2B730EEC988A754" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P477</accession>
    <name>A0A370P477_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_311166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P477"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="53"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="56050" checksum="0507E42E50FBC200" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5B4</accession>
    <name>A0A370P5B4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_280005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5D3</accession>
    <name>A0A370P5D3_ASPPH</name>
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        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">M752DRAFT_310156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5D3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="524"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="655" mass="69682" checksum="E6898846615A2F79" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5E9</accession>
    <name>A0A370P5E9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5E9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="76" mass="8880" checksum="F69FE754C5ADB3F7" modified="2018-11-07" version="1" fragment="single">MCTLKDWALPWIRSPTLNELYAFIASQLEGRVMDTVKARSHLNWFSTRYTASRALSHPSHLSFIFETVSMHLWPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5T5</accession>
    <name>A0A370P5T5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_93477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5T5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="70" mass="8024" checksum="E3D664A7C4C78C54" modified="2018-11-07" version="1">MKQPLATFSSRYSLFSFSFFPIFFPTCYYIYAYVHCVSVVDSVAAEQVKHDIGGDLGLCTISRSWTRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6E5</accession>
    <name>A0A370P6E5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_241685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6E5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="355" mass="39186" checksum="C6F4ACAE6BFCA808" modified="2018-11-07" version="1">MYRQSFAPPPAQSPPLHHPVPQHVSTVPMMRSPPPPASQQPQTSGYGNPYQPAPAQGGSGTYAPGFGGFINDPTAQMGFQVGKTAMAAGQEYMEQNFNRYVSIPALKHYFNVSNSYVLNKLSLVLFPWRHKPWSRQQARLTTASTGPNGQISQQQYSSMFLPPRDDLNSPDMYIPVMALVTYILLSAMLAGFRGNFHPELLGSITTTAIAVILFEIMCLKLAMYILSINNESQLLDLVAYSGYKFVGIIVTLLTSEILTPGRGTGGWVGWVVFIYTFLANAFFLLRSLKYVLLPDSTSDASMRTGSMHTVARSQRNRRTQFLFIYSYVIQFVFMWVLSREGPMSMASSGGATGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P795</accession>
    <name>A0A370P795_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_307871</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P795"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="946"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="194"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="788"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126877" checksum="2391C7C0A75A4414" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7J6</accession>
    <name>A0A370P7J6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_297997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7J6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="17383" checksum="2568FE664896254A" modified="2018-11-07" version="1">MLAWSGMDFGARFELSAMPYSSLTRYHKEQRRLMRFKNLKKANGSFSSFFIKAFKFTRALTTKSHLNSVLGAGNVGDTSVDPGHYLKPAITEATDKTLEVAARYGIGGHAAAFRWTAWYSILRKLYGDSITASPVRALVTIKNAYDLATCDLWTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7W9</accession>
    <name>A0A370P7W9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_222661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7W9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="582" mass="61939" checksum="EBBE5F3AC16906FF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P847</accession>
    <name>A0A370P847_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_308055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P847"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF53">
        <property type="entry name" value="ENDO-4-O-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="55828" checksum="FFB0F64AFB008E4B" modified="2018-11-07" version="1">MANQKNVLLLIADDLGKQLSCYGDNTIQTPNLDRLAEQGTRFDYAFASTASCSGSRSVIYTGLHTHQNGQYGLASHRHHFVTFDHVKSLPHLLNEAGLWTGILGKIHVGPSAVYPWQLRKESDTRDVAVIADQARSFFEEAKASNRPFALTIGYHDPHRDRTRGGFGNTDDYDPRITKIHLEPEDVPIPSFVNDTPGTRSELVEYYKSIHRVDQGVGFVLDALRETGLEDSTLIIFISDNGPPFINSKTTLYDAGVRLPLIIRQPSTPPAVSLNMISYVDILPTILDFVGHPEVTDPEKKRLGRSLLPILGNSTSLPDFDQTFGSHTFHEVTNYWPTRFIRDRRYKYHRNLAWRLDFPFAADLYGSLSWEDIRNSSDTDILVGGRKLRDYFFRPPEELYDLEEDPREVHNLAKDPAYAAILDDLRLRLEKWQRQTEDPWLYKDGVSVWFVRYHLPAGLRIPDRLDFDAENPGNKDGPVVPHNLSWGSEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8C0</accession>
    <name>A0A370P8C0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_257263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8C0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="225"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="427"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="771"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK38409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="871" mass="98223" checksum="81E5297306D9E097" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8I7</accession>
    <name>A0A370P8I7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_80484</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8I7"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="346"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK38503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="688" mass="73075" checksum="DB638263AC31A795" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P969</accession>
    <name>A0A370P969_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_307434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P969"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="58594" checksum="C78F1D787F177ECC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P988</accession>
    <name>A0A370P988_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="301" mass="33494" checksum="A4ABF737D3E7A618" modified="2018-11-07" version="1">MADITITESEFKLADGTVLYQKTWSPAAPRAKLVHFHGFSDHINSYNNFFPLLARRGIYCSGIDERGWGRSAPTKSDRGNTGPTSLVLADMAAFIKDQQTNVFPELPLFINGHSMGGGMVATLASTKEYQPLVSSLRGIMLSAPLMGLTPEQTPSWVTVFVGRLAGKLLPRFQLVQKMRVETLVRDPAVQKSLKEDQLNHATGTLEMFANMLDRMMALDEGKLTLVDGVQSVFLAHGTGDNCTSYDASKRWFERETARFPETAKMHKSYDGWSHVLHADLPETYPIYAEDMATWILDKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9V6</accession>
    <name>A0A370P9V6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_307027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9V6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="54378" checksum="8894C93D417D9FEA" modified="2018-11-07" version="1">MKVEPKTTDPSTSKDVNIDVGTIRLHFSAEEEKRVVRKIDCFILPLMCLVFFFQYLDKQSLSYASVFGLIDDLSLEGSEYSWCSSLFYLGQLVAEYPFIYLMSRLPLTKFVGATIVFWGAVCMCLAAPTNFAGFGAVRFLLGVTEGAVSPAFVTLTSMWYRKKEHASRVGIWVTMNGLAQVLGSLLMYGIGKQHYPRLEPWRVLFLVCGALTAAFGVVFYFLVPTGPQKAWFLSEREREVLLARMAQDREGGDRTNFSKAQVIETLLDVRAWFIFAFGILVTMQSPVLTFASLIIKNLNYDKYQTMLYTSPSGAVQIVAIWIGVLGCQLLPNNRSLVVILLSIPPLIGNVLLLKLPLTTGWGLIVSSWLASCISDVMVILLSLSASNVKGNTKRAMANTMYFIGYCVGCIAGPQLWQTKSAPRFFEGVVTAIVTWCVLVLAMVLYWYLCRAENIKRDQDTRTSAEIVLHTEDITDIEDRLFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA75</accession>
    <name>A0A370PA75_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="197" mass="22079" checksum="5CE3EF49D260B26D" modified="2018-11-07" version="1">MPIRCHVRLAYSNYCLLRIQQTHRTWVDRSAAGENYERLVMMISGTVFLFDIYRRTRGIDENKPGKVQSRATGPIWIKCAGPPMSPCKQTLSASTVALIGELIFGVVTGKSKTSVLTLDCLLEKWEMEMDKSSSICVRKELRMIRKAGLEAFSMSPEGPDDGGKSQKRDSYCTKKRKCNLSPVSSDLKDPLPATLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB92</accession>
    <name>A0A370PB92_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptomycin 3''-adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_57436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB92"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="AadA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="AadA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylyltransferase AadA C-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="28804" checksum="F8FE82313341E370" modified="2018-11-07" version="1">MDNKLPEEVEAYLEKLVERLTVYLKDQLVGVYLFGSASYDAYEPGLSDLDVQAIVKDQLDTVEKQAVIHQVNQAALPCPATKLEFVVYSQSAVYPASRHPRFELNLNTGPHQPDHISLDPANESSHWFLLDIAMGRELGRALCGPDPTLHGPDPTDAFGAIPRRWILEAIADSLDWHQANEVNSANSVLNACRGWRFIITGEFSSKLDGARWAIQQQGCPDIVRRAIAARRTGDKLPAAEVMTLYDIVVTANRAQLATDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS9</accession>
    <name>A0A370PBS9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_320600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBS9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="65921" checksum="3F612BD7803CDCFB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC16</accession>
    <name>A0A370PC16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_255465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="56155" checksum="22F268E957EC6837" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCF6</accession>
    <name>A0A370PCF6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">M752DRAFT_328539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCF6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="196"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="927" mass="105934" checksum="EDE61D315DB7FAAF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCG6</accession>
    <name>A0A370PCG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_45503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCG6"/>
    <dbReference type="SMR" id="A0A370PCG6"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="331"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK39875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="58432" checksum="372C7B78CDAD9224" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCL0</accession>
    <name>A0A370PCL0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="54907" checksum="23E42C127A559CD1" modified="2018-11-07" version="1">MAPGSQNSRSKDKTDKADKSDKAEKSYSSAIKDLKASAAAVLQHLETLDTVENLQRKVKELTDQLAEANRKVEEAQEEQKQEKATRQTMVKDFGERLLELKEKEDKLEVELEEQRKKAESSSQKKDQERDAQLEKYNTRLHEVEEELDCEKARNAELELRLRRKQKTLEDLRGDFQIIPLEQNAFESFKHLESSLYELTERYFKEFLHLSDRVPHPFRHASHLMFLSYTDHRPVPRARVAQFCIAARLASHVFQPMCIGSPRGTTSMGDALQKSEKIQPRQKAILRSLLFTAFETDEERVQTDLIQSVASELFDELKGILSTDNDNAFSKELLSYLETAARVWNKSKRVSEWILTSSDPHINRQPWKMIKGDSNKAVAGQESTNSGMVIFPQIYIDGNNSKYYPGTLWSFDSGPVEEKRTAQSPHARRVSASRSSKSPTVAEASSDPGATASRRLASRDKVSEMGRKVSSDSEGQRRCKSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCV5</accession>
    <name>A0A370PCV5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_237863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
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            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
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        <location>
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            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
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        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="785" mass="84311" checksum="3AA8B429A436A235" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCX2</accession>
    <name>A0A370PCX2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_254986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCX2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="38"/>
        </location>
    </feature>
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            <end position="242"/>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="54249" checksum="CD5F0F205900F99F" modified="2018-11-07" version="1">MPPRKQWIDKKTATTYQLFHRSQHDPLIHDPSADDRVLHPVYGPPITPSESSSASKHRGQSLAELNQTFGDAARKNEGEAANYGIFYDDSQYDYMQHLRELGTGAGDAYFVEAKTKGKDKGKGLKLEDALKQVSLDDGRSEFGGTESVYSYDMRSTASSYVRKPTYQDQQNVPDAIAGFQPDMDPRLREALEALEDEEYVDEDDEEDVFGQLTTRAEEMDQGDWEDTIFDDVEEEDDGWESDATEKAPVQMDTTAAKARYQASEQEDKPGELPEHNEPAPDMHPEDQGWMREFAKFKKDAKSGKTAGVPAGPPSVVPSHQGSTLASTVFTVGGTPIRRKKRKGALTNPSAYSMTSSSLARTEGHRLLDDRFERVEALYSLDEEDEFDDNMSMVSGMTGMTGMTGVSGISTASSQAPSLVDANGDAVRPSHNFNNIMDDFLAGWDDKTSSQAKRKGAKAKRGKNGNEAIGIRMLDEVRQGLGPARVTGKVSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCZ0</accession>
    <name>A0A370PCZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_255044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCZ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF21">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="222"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="535" mass="57571" checksum="A81032FB6823CFC8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDB2</accession>
    <name>A0A370PDB2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="494" mass="54989" checksum="E4F514021C47E3FC" modified="2018-11-07" version="1">MSPSKQSVAMADMPFIVSTGTKKVDPRTRKLIRSHVMIGKNRGKSRYRQAEADPSTPADTSTDDTSAPPADGAGSSSTSPAAQVPATRLPLDLPRRVGNDMSLIRLADDTTSPAALATILRFTDRAKMEFYPLAVCIVFNKSSRSWILDMLSLDAAYLNAMVITTQSYFGIYKGPDAAQSPHLGKAIRLLRNRLEDEQVRVSNATVMVVIILILHAHIVSDYAAVQHHTQGLRKMVRLRGGLGAFTSNNKLVIDLIRCDVGLAIHSGDKPAFFENRDLDIFVPSELCFTARSRPDPSFVRELDPGLARIWHIMQGFCAQVNLTTKTNGMIPETDFMKTMASAMYPLLHMSFDPGSRDEAIRLALLSYGFDIFLQFRSDPTPYVHLAASYQRCLNGLAKRDDVSPQLWIWLLTVGGLVVFLPAVRRNFRHWLLYYLGSCRVRSWEEMRAILSSFIWIGLVHDKGGKEIFDKLFANLEPGAETFVDQTSSSKLITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDC5</accession>
    <name>A0A370PDC5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_254194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="479" mass="54131" checksum="6FDA227E4A338A28" modified="2018-11-07" version="1">MHIIWRNSAEPAVYEEARVGRVFNHRRPQRFPLAVVKATTTSDIIAAVKLAAEKKCRVAIRSGGHSWAAWSVRDESILIDLGNYKHLEVDAENRIAKATPSMTGKELNGVLIKEYGLMFPGGHCPDVGLGGFLLQGGMGWNCRNWGWACERVQAVDVVTATGELLHCNATENRELYWAARGAGPGFPGVVTQYHLELIPYPKDGFRSSGYVYPIRQYRQVFDWLLSITPGFDEDTEIAAVAAYPEGIDEHCFFVLFVAMKSTPEEAEKALLPAQITRPAGAIQEWFCQVDSLENQYSKQAKANPERHRYCAENAYIRNDADVPTVLEEAFTTLPHKKAFALWYAMYPCSRRKLPDMALSMQSDHYFALYTVWEEEKDDDRCQAWVADVMKRVQRHGVGSYLGDADFQVRKSRYWANDNARRLMDIRRKWDPQGRICGYLDQGDQSGTRGLDNAKEIKDDSIIVNVRAFLNMITAATSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDH7</accession>
    <name>A0A370PDH7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF829-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_337428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF14">
        <property type="entry name" value="INDOLE-DITERPENE BIOSYNTHESIS PROTEIN PAXU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="32301" checksum="3902946C77203C97" modified="2018-11-07" version="1">MLSAGFIPLSDRVYLRNGRRRSKTTGTVEPTTIIIFGWGDGMPKHVSKYADGFHDLYPSARILVVLSSTLQALSQPVEERIQDMMPVIDTVFPTATGGGKDEERVLLHTMSNTGGIFLAAAFTAYQKRHGADNRFPHKLLICDSTPGGLSLSRQAGRWSRAIAVGTSKFFPWPFIVTQALWFVLLWVHYILERLRGLEPSGVWADRVMNDESVTTRESSRLYLYSKEDEIIGFEDLEENVAQVKTLGYQAVDLELFEGSPHVGHMKLHPQQYWGKISECWKAAIARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDI5</accession>
    <name>A0A370PDI5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_303784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="507" mass="56199" checksum="9503CE14EEDC8BDA" modified="2018-11-07" version="1">MTRESNIVGGSLAAALPVTDKYWFQQPHLLRLNLVLLIFLLSSSTFGYDGSLMNGLQSLEQWQTYFSNPTGSLLGTIVAAQSIGSVIALPFLGNLCDWYGRKPILFTGLVIICVAATIQCVSANLAMFIVARILIGIGGMFSSQPSPMLIAELAYPTHRGKYTSAYWTMYYLGAILSSWCTFGTQSLSGSWSWRTPSILQAGYPVVQLAFLYWVPESPRWLVAQNRIQEATDILKIYHAGQRNPEEVPSPLVAVEIAEITHAIEFEKSFEATGWSTLRATPGNRKRTTIAICVGAFAQWNGIAVVSYYLSLVLDSVGITSSYTQTLINGFLQLFNFAAALMAAFLVDRLGRRTLFVWSSIGMFISFIVWTTCSAINSETGSKAADYVVIVCVFVVYFHYDIAWTPLLLGYPTEIFPYSLRSKGLAVEMMSVYGSLIIASFCNPIGMENLGWRYYIVFCVFLIGILAIVYFYFPETKGHTLEEIAVIFDGDRSDLRHGDDDCLADGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDQ3</accession>
    <name>A0A370PDQ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SNF2 family helicase/ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_237851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1333"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1591"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1605"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1679"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1713"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1734" mass="194748" checksum="2570F330F1089575" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ6</accession>
    <name>A0A370PDZ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_218638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="483"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="771" mass="86056" checksum="F1642E7B826812DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE00</accession>
    <name>A0A370PE00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_337570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="208"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40768" checksum="44878047489A45A7" modified="2018-11-07" version="1">MPTPIIDSHIHLFPASHLPTLAWYTPSSPLGSQHSVDEYRLATTSIPTSPETTTDSHYLRGFIFLETDRISSIEESDPTRGWSHALDEVSFLTRIITGDPVPGEGHKDVDRHLCLGMVPWAPVPGGPAELEKYISLVRERTRTEEVFRKVRGVRYLVQDKPSGVMLQPEFIDGLRWLGRQQLAFDLGVDARQGGIWQLREAAEMMNTVYRGVGEKKDRVRIVINHLCKPNLRLPYTSPDSIATHPDFLEWSSLITAMAQHPTAYMKLSGGFSELPPLTAESEPDIAALVDQVQLWTDVVFDAFGPERVMFGSDWPVCNVGGGGSAVAWRRWRSVVEGILEKRGLSQEQKEDVWGGVAVKAYAIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE87</accession>
    <name>A0A370PE87_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_218426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="68097" checksum="30A9432519CC4015" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEA0</accession>
    <name>A0A370PEA0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="6">1.1.1.1</ecNumber>
            <ecNumber evidence="7">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_295421</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="6"/>
    <dbReference type="EC" id="4.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 18" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="19">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="963" mass="105067" checksum="95D3466ED4CCF5F8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PED3</accession>
    <name>A0A370PED3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_284793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PED3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39802" checksum="CB23443F00DBC01F" modified="2018-11-07" version="1">MTAFNVKDLAARAAQRIAEHRQKAEARGSTFSTEPLPMDRVSSVDANSMRTMSHSEDEHRHKSKMSRLVQKVRGRFSKRLAKREVIDEPCACCLDIMPAECLISMPCQHKYCSRCLKKLVFTVMPEEGLFPPRCCKQKIPTEVILPVLTPKERTVYFAKVQEYATPARERWYCPAPTCGRFIPPKHLNSKLSSQSCPYCSTTFCSGCRCPGYNNSTSTGKKDPGFMAVFEDPRLGKAQRGLKCGSLVDLLFNCDHVTCRCKAQVCNLCRNPWLSCTCAKPGQRPIDFLTFIIGHSGVNKDQEAELAAVVAAILCNERLRDEELAKTQGMKEKGGSANRSRASLLIPQQATRARRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEI8</accession>
    <name>A0A370PEI8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_34787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEI8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="383"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="59004" checksum="E67DE1342BF642EA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF16</accession>
    <name>A0A370PF16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_295209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="176" mass="19771" checksum="238B79C9412B48D0" modified="2018-11-07" version="1">MSDQPTIRLATPEGKYVPIIHQFICELADYEKALHEVEATHGSLLETLSFPDSPPKRGSVYTALITPPATAENPTPKPVGMALFFYNYSTWRAAPGIYLEDLYVQPSARGNGYGFKLLKYLAAKVLEIKGRRLEWSVLKWNEPSIKFYEQVGAKAMDEWTKMMMEGPALNKLAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF44</accession>
    <name>A0A370PF44_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_303538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF6">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="629" mass="70083" checksum="2BCB144247CB21A8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFN1</accession>
    <name>A0A370PFN1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_284507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36525" checksum="1A1E5D8780DA6646" modified="2018-11-07" version="1">MSSAKPRILFFNPVRHAVPFYEKLQEHAQTEVVTSKGREEFFKDVTGKYKDIFAIYRTSASGAVAGKFDAELINHLPESCKYIFHNGAGYDPIDTEACAKRGIIVTNAPDPVTDATADLAVLLLLGALRNLNPAIRSLYAGTFKQGVGFGHDPQGKTLGILGMGRIGRAVKQRCEPFGIKTVYNNRRPLSADLSAGAEYVSFEKLLTESDIISINVPLNANTKHLIGAAEIAKMKPGIVIINTARGAIIDEAAMADALETGQIGAVGLDVYEREPEINEKLAKNERALLVPHIGTHTYETLAKMEEWAMENARRAIMGEVLLSPVPEHSELVNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGP4</accession>
    <name>A0A370PGP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_327506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="446" mass="49925" checksum="8097BB34A43BA459" modified="2018-11-07" version="1">MEGWRKTDFGGFEAGMSDNYQQPTKQLTNPTQLNPLMQVLIRTQRHNSTELSGPINDSLLHFMCRIDWLVSVVGPVMPHACYYTLPSAYLTLGYSVNRTRYTCWLNSSLLVQKAKMGRTYTRPEFLLLIFLAGAVKLDGAKVILNILSTAVLSNNYWMDIDQKHSGTGISMAERESQFLVLGFACKEQASQEHDEQARNAWCKRVVLIVTVKSGRSYKAIKDALGIDNDSPVFTRACSQTESLPPPPSFMRHFAVFLVPQAIWVDETMNLLQKFEHGSYFELVGPDMTDKEGGGVCWREEKVRSIDGIEEVGLVTYDNEAIIESSCMILPDPDHKQLLRRLLLFICDSRLWALKYAINKSHGRMFTTGWAGAMISGLGVFGSALLVGAAPVVFPIACVGSCTFGLGSGILGSWRSGRVGAKEYPEWRRRSDKLEQQFPQLRELIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGW9</accession>
    <name>A0A370PGW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_319655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000113">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="58571" checksum="62C7961425EF7F35" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH15</accession>
    <name>A0A370PH15_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_276937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="54444" checksum="10FB81C4D8BDF985" modified="2018-11-07" version="1">MTLPDSSSQLLSPVDHTVPKVYFTFYLSFLLKNPQAGVESIQKGLTTLINQLPFLAKDVAPSHDENHDNVHCIQPPSAKSQSIPMLQIRHYLNESVRSMLATASCTGAEDLQYSERYAPLPTVMDPQESQPILRFVANVMVDGIILSLSFNHMAADGTGIGNILELLSGCCRNEQKHVGPQRFDVELRRQLASPSTTAEKRPLITFWETYTPEETFHCLDSNTWSTATTSMASELNTFRFRIPIRKVKVLKDICTSVLLSHREGDNMLSKEPGAFISSNDVLTALLSICLQQMQIAELSSEDDQDYTVAFVANLRSRMHPPWPEHYIGVLLTMVLVSRSELINYVQEQKVDLAASEVGLDKDELVQITNLAMNMRKKLQDVDDGYVRGLLAHMQQQRDWNQMNIKGGDFSYSSIRHLKVHDLDWGPNLGKMTGFRLFFGLLEDFCLILPADLGGDWDMQISLRPGYQRALMENRLFRWATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHF2</accession>
    <name>A0A370PHF2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_327656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000036">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="178"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40619" checksum="FA57C9FB957C3BFE" modified="2018-11-07" version="1">MISSSSSFTSIPVLDYAQASSADDRPKFLANLRNALVNVGFFYLINAPIAARVRDELIEKTFHIFDLPLEKKLEIEMVNSKHFLGYSRLGAETTARQIDYREQFDFATELPPPAPDAPLYRNIRGPNQWPDEKAIPGFRHAVEAYLAEMSPVAEAFRVLIAEALDLPPTALQQFFENPTQQKLKLIKYPPPSTPSEAQGVGAHKDSEFLTFLLQATPHTGLEVQNKAGEWIPAPPMQDSLVVNIGRALEAITGGVCTATTHRVNLEAENFVDAQGAPLGPRFSIPVFQGMSLDLSAENISLNIPAHIKDLIKDDKVRSDAEATFNKIFKGRVGEGTLIHRVMSHQDVGRRWYPELLDWALGEYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJB5</accession>
    <name>A0A370PJB5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_326911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="357" mass="41881" checksum="B2F97BE97870F88D" modified="2018-11-07" version="1">MIIAEPTPTPKMDTVFSITELVEYILLRFDIFDLMRAQQVCRQWRTLITTRGPLRTALFYDFPHPYPTEPTFNPLIRYLLPVIYPVPDTTKQTSPIFMPEDIQTIRLGNDTAYHKAVFRPEASWRRMRPMNIPCRVRKVVSLTVEDDQDPAKNLMVYDKEAGQDPVLGATMDLVWDVLLHVLGRWPTNGMAVEWRPVREGSGEWDNNWMEWMSDEEKERLRAPYECSVVSSTPDPLFGKCDWEKFTFVRVKPAVRMKTTAREYLGMKNQYALDKFDSKVWGPDLPPKFAHKGDWKWVNDDGTDGVLWDQGEGRQQNEDDGIRPVEDENDSGTEWSWDEVKEYFDRPDCYWVPYYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJR4</accession>
    <name>A0A370PJR4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="278" mass="32009" checksum="30B114EE42F70259" modified="2018-11-07" version="1">MSTPISKGYDRLAALMARDPGSSIYRSFAKLNAKNLLYLQAEIAYIQIDLQDIIKEDGQSEDKVSFPFSVWAMKNSEDPVQWKKFLEARKLLKEYNTALLHQAQLLRLNAPEKADLEVFKAWLREEESRNMWFSPPDQWGGENEMDLVALNSRHEETDRFTRFVYTRVLSWFHRMVGVNDTKRKDIESGVWYYNDRTIKSWTYILSLFISGLLPATSMIVLYFLKDPAAILITICVYDMVFVLVMGLMVKARRVEIFAAATAFAAVQVTMITAGKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK83</accession>
    <name>A0A370PK83_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_276422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="119" mass="13627" checksum="7DD74A589F959D7E" modified="2018-11-07" version="1">MSAQNSAGIQTLLDAEREAQKIVQQAREYRTKRIREAKSEAQKEIEEYRKQKEEEFKKFEAEHSSGYKKAEEDANKEAEVKLQEIKDAGNERGGKVIETLIHALVDVKPEPSEKIVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKC0</accession>
    <name>A0A370PKC0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_265537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016645768" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="20311" checksum="D944AE47105A9DA0" modified="2018-11-07" version="1">MVFPWLMIILGAVFRVAEAASLPIVDLGYELHQANSFSLRQHSICCSTFGPTSLSATRTTHDKSIRNPDRRRRESMPPGRHASVGTGPAYSLPEEPEPVPEKFPAEGEFEQWAIPQVPPDTEGGPSASLSHSDTSNHEKLPKAPYQTQAQGHIARISCADLMLYQNWESLSSKYKKKRDIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKR3</accession>
    <name>A0A370PKR3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_315186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKR3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000922">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="64"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="404" mass="46127" checksum="1932050060DB10BF" modified="2018-11-07" version="1">MASLLKWIRASIHPRRAPLPPRRFPTTGFTTIPASTILEEEHFDSFRNGHYYPVNIGDVFASKYQVIGKLGYGSTSTVWLAQDLLSHRYVTDESHTEEFKIYQHISQANPSHPGYGYVRTALDTFIIPRPGGDHPCLVQQPMWDSFHDLLFRNPRHRFTEDLLKAGLMQVFLALDYLHTECRVVHTDIKGGNILQAIEDESLLDAFTAGEMERPSPRKLLDGMPVYASRRFGLPRSFGRAVLSDFGSAVRGDESRDHDAQPAVYRSPEVMLQVEWSYPVDIWNVGVMIWDLFEGKHMFYGEDPDGKGYSTRAHLAEVIGLLGHPPLDLLQRGKRSHEFFTEDGQWKQDIAIPHTGGVQSSEEYLEGSNKEGFVNFMRGMLQWRPENRKTAEQLLRDPWLNGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL43</accession>
    <name>A0A370PL43_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_163681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12378" checksum="B17DEDBC100B1DC6" modified="2018-11-07" version="1">MDFFLAFISASPGVAGRPLPLNTRLVHWLATDPCARSLCLVMVISPDSGVSWMTRAQARAFNQPTMKQRVGVQTSDKFYTLGWFRATREAHACRSGASRPTDFPFEKVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN1</accession>
    <name>A0A370PLN1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="602" mass="65820" checksum="DD71F27CCB5D521A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLW8</accession>
    <name>A0A370PLW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_282997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="547" mass="62178" checksum="1D6C7E662F44DB10" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM36</accession>
    <name>A0A370PM36_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_265151</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="141"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="447"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="54105" checksum="AB60E435C5D47982" modified="2018-11-07" version="1">MRGSEASGPGALFDAPSTLATSLGINPTAASEPPPTDPKLVASNIEHVLLSMSEGNGGLVSVSGNSSGSTGKGILIGVLSAFGSAAVAVLVLAVFFFFKYTQRGRIILDRIGRPGEFDDEQAFAREEAEALETMDDLTRSEYMRAKAFIEANPPESVQTDISLSQFLAIQEKGVSAWEFQPELEIANCFVEGRTEIEFYDSECSVQTNLPVPKQNDVYYWEAKIYDKPDNTLISIGMTTKPYPLFKLPGFHKTSVAYQSTGHRRHNQPFAPTPYGPHLLQGDVIGVGYRPRSGTIFFTRNGKKLEDVVHGHKAQNFFPTVGANGPCSVHVNFGQMGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRESAAQISQRVYQDANNARTSSTVRVAPSASPGPVRSPTDISLAQLAHIPSNEDVGEGSSRTNVVDGEQVPLLHTNDLDQVPPPEYSSPDGSRRGSEDLPFDEQPPIPSYDAAVGNRDGHSAHANENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PME1</accession>
    <name>A0A370PME1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_250064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PME1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="350"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="754" mass="85121" checksum="7B50B9CCBD4000BF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMR0</accession>
    <name>A0A370PMR0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_326293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="59801" checksum="4074F6B9E9BE4ECA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMY9</accession>
    <name>A0A370PMY9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_158336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMY9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="144" mass="16603" checksum="3A73284015CF071B" modified="2018-11-07" version="1">MAGASTRAAALSLVRVDGRVCARLVSSSYKKRASVPEFVPRIFTIYKLFPGKIRFASSNSGRFRFLYVFELGTYLSCRWCRIMMVRDRHNSIRELAWNVEVAIWSLHEGEGEYPRQLDQKMLVCAYESHISCLSSSDRGIRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN60</accession>
    <name>A0A370PN60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="12">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BNA4</name>
        <name evidence="15" type="ORF">M752DRAFT_250447</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="12"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN60"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0274">FAD</keyword>
    <keyword evidence="2 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK43620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="54741" checksum="AAF9966B49E6EFEE" modified="2018-11-07" version="1">MSSYKVVIVGGGPVGALAGLYAAQRGFQVEIYEMRDEYSQVQTATAFSAKSISLTLSERGIKALRHSQCRGLAERILSTTVPVYGRMVHSRSKKRLTSRRIAYDVHGQALYAISRSEINQSLLEELSAFPNVHIFYKHRLNGLDMKQKCATFHNISRPQEPSHETKFDLLIGADGAHSTTRFFLSRYAKININQKWEDIFWCELTIPAGHALPMDCLHMWPQRDFMLFACPDKEGTLTCNLFAPENVFLELKSSGRIVEFFEKNFPGITPDLIPTDNLQKQFKSNLHHPMIDIRCSPYHYQDSCVLIGDAAHAMVPFYGQGMNTGFEDVRILFEDFLDQRRSFPSWKDNLSLSYAMQQKELPDTPQAIVEDYLEQYTKYRQPDVHIINELALQNYRELRQGVFKMSYHIRKHIEEFLSLHAPQLGWATQYRLVAFETMRYTDVLRQVRKQGLILSAVAWSCLVLFFLLCLLSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNF2</accession>
    <name>A0A370PNF2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_282682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="57326" checksum="934D30F332339271" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNS3</accession>
    <name>A0A370PNS3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNS3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33872" checksum="5625A3BBE2E7CE97" modified="2018-11-07" version="1">MPPRILLQPSLRALTGPSSVQLPFAALSLNPAKTSVRAGSTESRERRRHDPFLMAQSRQRKAANISRQKALTKEREGSVGDPVQSEPTPFIQELRKTQATLQDTDLNYFVTPDGLNEAMEYSKNLTSPIRNPDRDTADPQLEKEAAEKHLQEHRNAQEAIRRIVSVANGNTKDHMRLHIQKCIETFGRHKTDSVLPPKPSGVSHDSATVHLEKTPRVGPDTGSPEVQVAILTAKIMNLSRHLQTTKKDRHNKRNLRLLVHKRQKLLRYLRRKERGGPRWQNLMEKLGLSEAAWKGEISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNZ9</accession>
    <name>A0A370PNZ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_313861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNZ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12088" checksum="FF584784023A289E" modified="2018-11-07" version="1">MVLQVKSKAAMYNVPRYGDIPNVFFDIDSRGAEDLLGTSRSEEKNPIVGSWFRIEKGPEATPPTYSYDEVGVVIEGEINLRDESGQTATVRPDSYGVAWKCGGREMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPH6</accession>
    <name>A0A370PPH6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_334924</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPH6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="958"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1038"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="310"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="952"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDK44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1229" mass="133631" checksum="441B3CC536DA67E3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPJ9</accession>
    <name>A0A370PPJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="152" mass="16861" checksum="05FC10EB84FE4B53" modified="2018-11-07" version="1" fragment="single">MVLLTALMPPFRDSRLMPAAIAGMGLIMIHHTSGRKWQGYAAPNHGLRLGNVVLVDSPKSQFPRRNQAVRGGTLAWMEQGAWPPRLANWPDFCHSPKRKSTTLAACSLEAPCSWYIPEAFNHGRSPVGGGVFALNITCPQAWDFHSQETWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPL0</accession>
    <name>A0A370PPL0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_334945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="486" mass="52495" checksum="993D392FF10AC6BA" modified="2018-11-07" version="1">MWFTTESRERPPWLLKYRSSTAFIIATVWTSSFTDYFLYAMIVPVMPTALVDRAKIPYEDRERWVSILLICEATVAFVCCPIFGYLIDVAPTRKLPYLLGLILLGASMLILCLARTIGFFVIARLLQGGATAMVVVAGLALLTDSVPFENLGQTVGYLGSAVTLGFLLGPLLGGLVYRVAGYQPVFAMAFAIVGIDLVMRFAVIEKRVAKRWMALSQDDADSNNETNHDNPSDDNPPQPDTTDNDATIIPKHSRKPTLLLLLQQPRILISSWGLLVHGMIYAAFDATIPIFVESHFNWTPLGAGLTFLPSSMTALFEPYFGRLTDTLTPHPIATATFLLLPIPLTLLALSSQPTTTHITSLMINLTLTGLLVNIATPALYLETQRVLDTMERRQPGIFGPRGAVAQAFGIQTMAQFLGLSLGPLAGFVEGRFGWGSVVVGLGMVCLGTGVVVGIGLKGDCCGYGGEGGGEGDVDGEGERERLLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ04</accession>
    <name>A0A370PQ04_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_318075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000237">
        <property type="entry name" value="Putative Valyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1282"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1330" mass="150344" checksum="35CB72BEFCDEFF5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQM0</accession>
    <name>A0A370PQM0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_140454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQM0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="75" mass="8504" checksum="12D9E95100A33850" modified="2018-11-07" version="1">MPIPITYSHRMPPITSPFYTLYNPRSQGKISFIPGYTVIVSVIFLLLLPTRMSILLWDVYTRTADLQLLAGDVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQM4</accession>
    <name>A0A370PQM4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">M752DRAFT_231471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="399"/>
            <end position="605"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="806" mass="89826" checksum="B6D2B67EE9DC6A1C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRI0</accession>
    <name>A0A370PRI0_ASPPH</name>
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        <recommendedName>
            <fullName evidence="14">Rna-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_333725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK44817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7066"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="119"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="277"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70017" checksum="716F0A5DBC11EFC2" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRN1</accession>
    <name>A0A370PRN1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_141747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000254937">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="127"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="413" mass="45671" checksum="5924B465FA97F815" modified="2018-11-07" version="1">MRTRSSAPSEQPQSPPSTSDHQTTAASTSALPAQSTPQKTFILPSTAGADARFLTLPNPRTASPTRYFFDPKLGVYEFTVLSSPPTAPRSTLLVRNPYPTSSSTSQPPAHISKKAELLLATPIDILFFLIPILTANTKQNNLFQPLDDIIDSLDEELLPPHLRHVLYDETFRGTLHARAAAISDSVEAGDEKMFRFNETKLLQELVAKADRMVSVGLPPSLEERFVRQALATPLMAVKRDDVVATGENKENEGEDGKEEGEKTTADNEDAKEHLPEGLKAPDGVANLLRISTALAFIKECYLSREMSARIDELLAAPESPKDFKPMRDHLDLVAKLRAEALATRSLGDFSRKRSVEDQEAAESRAEKKRRMEEEEKKKKANESRGVRDLKKVNTTGMKKMSDFFGKAAAKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS96</accession>
    <name>A0A370PS96_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_282073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS96"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="54781" checksum="E08A552A796F3DC0" modified="2018-11-07" version="1">MGQDEEVVKREEYTSDSVLDDKLVTWDGPDDPENPKNWSTRRKWLAVISISGFVLMSPLPTTIVSPAIDTIAEELNVTVTVQKPMVMSIFLLGYAIGPMFISPMSEIWGRTRVLQTFNFVFLIFNTACGVARSIEQLLAFRFFAGLFGSCTVGIGAGTLGDLFNAKDRGKAMAIYSIFPLMGQVLGPIAGGFLTMRTSWRWAFYATSIIDGCVQLFGLLFLDESYTPVLLRRKRDRLTKAGATGLYTEHDFPSDSKLDMMRTIMIRPIKLLSTQPIVQVMALYQGYLYGNIYILYSSIAILWTTRYHEKLDIASLHYLALGLGTAFAAEVATHINDRIFRIMTKRNGGKGLPEFRIPIMIPATVILSIGLFWYGWSAEARMFWLMPDIGIALFAAAAYICTVSNNIYVVDTYGRYSASALAATSMLRCLAGFVFPLFSPYAYERIGYGWTSSILGIIALCIGLTGVIFIWKFGHVLRKKSPYCASRDVDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSI6</accession>
    <name>A0A370PSI6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_230802</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="223"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="58221" checksum="1B95B821CA2A7038" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSV1</accession>
    <name>A0A370PSV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_291313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="15495" checksum="2FB98400C42AA0BD" modified="2018-11-07" version="1">MDICNLSFTFLLLSTTVMLYFRALFAHPIYITSPPAPVQVPAPSPTYTLAFLDEPVFKPLASHIAEHPYPWRDKRPFQETNYALLMGAVQSLLEAEIEEEEGGVALNESYAQQVVVESNSTETFLLWVGAGGDEQWPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT03</accession>
    <name>A0A370PT03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_118084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35312" checksum="7A6A21879F96A9B2" modified="2018-11-07" version="1">MENSTKEVNPFDILLLECQDDPKQIQARYEAHRSSRNEQYKERLLSPDFTGWQIDDILRKLQAGANGETLPFVDSRHNLTLYARPPQHIRDLIAEVQQAIREIAQSIWFTPPEQLHMTTLEIASCRPEPEVEGLVSHLQGSGVVPKLVDFLFHHRTRLVKPMISYDATAMALSFVPAAGEETTTAHNVDGDGYTYHHLRRDVSSIVTATGLQMKPRYIALSAHITIARFITRDGFLIDNPNKVEDEAVDHARVAALVERVGKINEMLRTKFWFQEDGAISGKGEWLVGREKGLEFCKGTSFYGGGEAVVVGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT53</accession>
    <name>A0A370PT53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="300" mass="34989" checksum="4F23BEEC3AA9B2EB" modified="2018-11-07" version="1">MACPGAKLNPLASEFIWHGNKTGHMRVTEKGVSAKNANQVEVPEKNIFTKDTEQGEEQNIRRLNKNSDFPNFTVKKHFTAKAAKGKESEVEYKIPCYINIKFTTTGGISYDLYHPLISYLNKPARRAFDHLQHLTYHNNQELQTVKFRVDVNPEKINNAAYFLEALVNLSKHLPSSKPYNAYRAHGNDPRIKYSQQRQYKQIKRLREVPAGIRIRRVRSTIMAHVRPDPEHLKNNLLPMEIKRTEIILPELIDNKLTRPDWQVTERKLHYQLQKINEIRDQQDPGEKTDKYSRKAVLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTC2</accession>
    <name>A0A370PTC2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_230832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="331" mass="37170" checksum="9E5B257A8A580DCF" modified="2018-11-07" version="1">MDRLHRMLQAAQGMGVGGNNGDIPNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAIDYRKTGLEENMLMNLHKHVWTEALQMKDFHEEGEHNVERMKQLVSLAEGYEKRVKEETTLTKDQLKTRYVGKVDPKKHIEDVSQQLIEDNIVAVSRQMIDKEASVARQSNGKENGTGMEVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTR8</accession>
    <name>A0A370PTR8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G00240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64727" checksum="C06F1C8AF82F6C41" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTX6</accession>
    <name>A0A370PTX6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_290484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="171" mass="18837" checksum="2371FDA555FD9642" modified="2018-11-07" version="1">MPTKPQTPSKEPEPIPEGWTDNPFYVQAEQENGFAYAYGLTNVSVLLPQGPDSREHGFICSSNGRYYLGDEMAYCMLEITKPTTYSGILHVVNTKGENGLKMKSLKMVPYAEQPESGPGDLWPGTGAVRRVPSYVLPILNSMETLMGLVVVMTFFKSFGIGYDVGWGSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU49</accession>
    <name>A0A370PU49_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_246877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="28"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="415" mass="46537" checksum="FE55090EA9F78A96" modified="2018-11-07" version="1">MTVLNLTPLPADEIFALNREYANDTFPDKVSLGVGVYRTDDGKPWPLPSVRKAEQQLLAEDSPFRHEYTAIEGDIPFLELARDLMFGFDSKNLCEEHKALKGRIGSVQSVAGTGANHLGALFLAHKMKPKTVWLSDPSWANHVTIWDLVGVPRKTYPYYKPETRSFDFEGMMSTLESDAQEGDVILLHACAHNPTGLDPSKEQWKAIAEICERKKIFPFFDSAYQGFASGSADEDAWAVRYFLNEKPQMEMCVAQSFSKNFGLYGQRVGAFHYVVAEGSQNLRDLVVNNLCHFIRGEFSMGPTGGCSIVKKVLTNDALTTQWHDDLKVMSSRIKAMRAALYDELVRLETPGTWKHIVEQNGMFSYTGLTPTQVQALKEKYHVYLIKSGRASISGLSQKNVAYVAKAFDDIVRNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV6</accession>
    <name>A0A370PUV6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_324711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="152" mass="16219" checksum="18FE65F5E8E582B3" modified="2018-11-07" version="1">MRYSQPLLAISGIIASAASTTTSFPANFTLISTLDNSVLTTDGWGIYDSTTGTTLTLSPYRDGTIGYGPYGQALAVLADQTSVAWIIQLQAEPEADDTVTGWGVSDDGFLVLNGEQLWAFNESAAEPRRLYWVGDGNEQGLVSTQLFVQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV83</accession>
    <name>A0A370PV83_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_97265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="285" mass="31569" checksum="9BDB5F0F1D841CD4" modified="2018-11-07" version="1">MSLSPEACDQYIPIIDSILARSDLTTISSKTIRNGLQDEIGYDLTPHKLAIKQLIMERFDVCAAQKGIQTASETPATSASTTNGHGKDHDSVTPVEPSSPAQSSMSQKRQAESEEHSDTSSKTPPVKKQKPDNDIDADALFAAKLQAEENMRARQTRGASTRRSQPVKKKQPAKAKTSKKVKAEDDSDLESGSDSGKKVNRSGGFHKPLTLSPALSALLDGEVTLSRPQTVKRLWQYIHEHDLQDPNDRRQIRCDDAMRAVFKQDRIHMFTMTKILSQNLYSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVM3</accession>
    <name>A0A370PVM3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_281482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016637014" evidence="1">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="302" mass="32587" checksum="2A654CBD0E208347" modified="2018-11-07" version="1">MMFPPSILFGLAVGIASIVPTIAQSTCNGQAEYCDRRFSNVTQVGAHDSPFVGSLLSDNQDLSVTQQLDLGIRFLQGQTHKSELDDTILLCHTSCLLEDAGSLESFLTTVKSWMDSNPDEVVTLLLTNGDSLSVSQFGDVFNSSGISDYAFVPSSSPDTLAMDEWPTLRELIGNGTRLVSFLDYGADASTVPYILDEFAYFFETPYDVTNATFPDCSIDRPAGASASGRMYIVNHFLDVDILGILIPDKDHASDTNAVSGSGSIGAQADLCYSIYDRLPNFILLDFVDLGEPIAAQNELNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW19</accession>
    <name>A0A370PW19_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_273476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="160" mass="17790" checksum="0FBD2E9BD5428608" modified="2018-11-07" version="1">MADEHHETFESADAGASATFPMQCSALRKNGHVVIKGRPCKIVEMSTSKTGKHGHAKVHIVAIDIFTGKKLEDLSPSTHNMDVPNVYRKEYQLLDVTDDDFLSLMDENGNTKDDVKVPEGEVGDRIRRMFHDEEKDCNVTILSSMGEQVCMDVKEAPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXA6</accession>
    <name>A0A370PXA6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_64273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="330" mass="35669" checksum="C95DB207582E246B" modified="2018-11-07" version="1">MLHTSHPQEFEKWTSMGPSDTQMLGLESNFTDEEFYGGHLGLNGFDLSSSQLLSPELCPEFDLATGETGSGLYRPSQPMGVANALDVPRLADKITSIFGESTFNTAPDTKPTAADFSLDDLLRSASQLATERALYMNIPTSTPSPRASHDSPSSRLHFVQSPLLDDPCSSPGMSQQSYSGSEGDWDRDFNQGEPVQFYGLPDIGFPDSVSLHHALDDGLVQPPFGDPLPTISNAEASSKSLSREISFTMDLDENGLTPLEMPDGSTRFTANWLPVDPEGGFTIRAPPTARKPEPNNDSNHQMAQDTGDYLFARNAFISIPTVTGLSSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXF2</accession>
    <name>A0A370PXF2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_65127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="282"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="413" mass="45725" checksum="23F610F5A876FC97" modified="2018-11-07" version="1">MSNRVLIAGGGLGGLALAQGLRKHNIPFSVFERDAKQDFRAQGYRLRVMQENLRTLLTPEMWSLFEKTAALDDGLPGVGVRLDALTGEPLPAGGGGGGPPPGIHGARPYTVDRGTMREVLLQGLGEENVHFGKRFERYEVKDDCVVAHFADGSSAVGGLLVGADGARSRVRRQLVPWYPFVDTGMRMIFGKTGITEDVEGRLNECARRGMSLARDLREEAPKTLLFEPMRMPKGDVEFEGGSVKLPEDYLYWVVLVHRSFVNMPDEKVLRLDGEESARLSLELTSDWHPSVRVLMEEQDVEQTSTLRMASVRPDLPAWESNSRVTLLGDAVHVMPPTGGQGVNTALRDAAVLVERMVEAKEGGRETMGEGDVVARYEEEMRQYARERVGLSWQGGYKAFNLKPLEECERVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXK8</accession>
    <name>A0A370PXK8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016771093" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="59" mass="6683" checksum="31B7841F09F36365" modified="2018-11-07" version="1">MPSFPLCLLSRLVLFLLIVVFILEAPGDRVKRGRSTDRMPSQYCPLVLTNCQDRFSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXR6</accession>
    <name>A0A370PXR6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_245060</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXR6"/>
    <dbReference type="SMR" id="A0A370PXR6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK46981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="458" mass="49857" checksum="D526F7E15413BAE4" modified="2018-11-07" version="1">MVQISEVKGNSRENRTAAHTHIKGLGLRQDGTAEASGDGFVGQATAREACGVVVDLIKAKKMAGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEETENPLGGYGRTISHLIIGLKSAKGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITEKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESSISPIVILASNRGNTVIRGTDDISAAHGIPPDLLARLLIIPTHPYSPDEIKTIIRLRAKTEGLNITDPALEKVAEHGSKVSLRYALQLLTPASILAKVNGRPGGIEEADVAECEDLFLDARRSATIVNQDSEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXV7</accession>
    <name>A0A370PXV7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_289135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="276" mass="30659" checksum="EC262FC30AF1521D" modified="2018-11-07" version="1">MLLGSCISEGLEAELLTGLASVLMLLSRNERSWLSPPTSIPKTPTTPASTRSARSHALYKLWGCLDKAMYLSSTRAAIESLIRSAFFDSSVPCDLLGASFSGIREALSSADEFDPQRALHAIINRRPHLSPLWAAEICMDPDTLSHEVLGCLPPICLPAALWTGTMQSFLQVAYRSDEPAEPEAKLLRAREFQIAYFCQPSIPVPETPAPPFGETILNNVSREVETHMAHEHMTRSWQMYWTTKSGAKKPATAQYVLELVEARMEKDVADYNFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYD9</accession>
    <name>A0A370PYD9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_317088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYD9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="10">
        <location>
            <begin position="485"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="611" mass="68660" checksum="45A595810B4E519A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYU4</accession>
    <name>A0A370PYU4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_332584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="407"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="697"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149034" checksum="B54A06B55433A1EA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ24</accession>
    <name>A0A370PZ24_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="496"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="714" mass="81025" checksum="2440BDCDA9B7B480" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZJ5</accession>
    <name>A0A370PZJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_331413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="44166" checksum="BFF891C8BBB471D8" modified="2018-11-07" version="1">MPPKRLTLAIAHPTITSTSPSQITQLAHSAAAKGAHLLVIPSYATPAAATARNKSPRDQYLKLFNCAHDLSDPGSDPLCHGDKKHKTRETLEHLAQETKLFLIVGLLERACGNLYHTVVYIHPGDGLVEKRRCFALTGLAKTYLSPGQPHTSPITVKCKSGLEVKIGVGLCEENYHPLIRQELYAAGVQVYISLGGVSYLDGSDSDSSGDETGLWESLLRTVAVEGRVFVLGSYTTSHHATLQPAHPHQLGSPTHIPSGSGSWQFSPSAKKRSLSVTAEGPHEIVWPEIRHANGGAAMGPRKSVTAEGPHEIVWPGQSNADVHEDGEGEMSPGRVEQRHVQAGGRGREGPSGESGCGGAAWIVGPFGEILAGSRGGVSLDDDGLLVREVDLEDCIRGRWDRDLAGVISTTELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZT9</accession>
    <name>A0A370PZT9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent RNA helicase dbp10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_271956</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZT9"/>
    <dbReference type="SMR" id="A0A370PZT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
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            <begin position="90"/>
            <end position="118"/>
        </location>
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        <location>
            <begin position="121"/>
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    </feature>
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        <location>
            <begin position="360"/>
            <end position="515"/>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="639"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="835"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="90"/>
            <end position="118"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="639"/>
            <end position="653"/>
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        <location>
            <begin position="665"/>
            <end position="682"/>
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    </feature>
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        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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    <feature type="compositionally biased region" description="Basic residues" evidence="17">
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            <begin position="915"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="932" mass="102626" checksum="93DB74AFA6D8A37A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q042</accession>
    <name>A0A370Q042_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SWI/SNF family DNA-dependent ATPase Ris1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_226661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">ATCC 13157</strain>
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        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="902"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1185" mass="132978" checksum="1D6E4DE52C10937C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q054</accession>
    <name>A0A370Q054_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_272046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q054"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="455" mass="50849" checksum="C7D781825F5AC16F" modified="2018-11-07" version="1">MPREIITIQAGQCGNNVGAQFWQQLCLEHGISQDGNLEDFATEGGDRKDVFFYQSDDTRYIPRAILLDLEPRVLNAIQAGPYRNIYNPENFFIGQQGIGAGNNWGAGYSAGEVVQEEIFDMIDREADGSDSLEGFMFLHSIAGGTGSGLGSFILERMNDRFPKKLIQTYSVFPDTQSADVVVNPYNSLLAMRRLTQNADSVVVLDNGALSRIVADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVGIIASLIPTPRSHFLITSYTPFTGDNIEQAKTVRKTTVLDVMRRLLQPKNRMVSINPSKSSCYISILNIIQGEADPTDVHKSLLRIRERRLASFIPWGPASIQVALTKKSPYMQNTHRVSGLMLANHTSVATLFKRIVQQYDRLRKRNAFLEQYKKESPFSDGLGEFDEARAVVMDLVGEYEAAEKEDYLDPDAGKEKELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0H9</accession>
    <name>A0A370Q0H9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_331675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0H9"/>
    <dbReference type="SMR" id="A0A370Q0H9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF3">
        <property type="entry name" value="ENOLASE SUPERFAMILY MEMBER DDB_G0284701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00180">
        <property type="entry name" value="muconate_cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="39695" checksum="6D3E700F8C325826" modified="2018-11-07" version="1">MTELRITKIDVFQVDLPYSHGTYHLSGGRAITRFDATFVRVTTNTGLEGWGESTPFDNYIASHAGGVRAAIAEIAPKLVGLDPRRVDRLNDAMDAALLGNEPAKSAIDIACWDIFGKSVGLPVCELLGGRTETKLPVLESIPVADPEGTRKHVADARALGFTGFSVKIGSDPVANAARVEAALVDKRPGEFFLIDANGGMTVDTALRMFRLLPKGLDFVLEAPCATYRESMSLRRRIDVPIIFDELANNESSIVQFVADDAVDGIGLKISKTGGLTRGRRVRDICLAAGYTMSVQDTSGSDVAFAAIVHLGQTIPEQYLRCILECRAMCVGKTADGPFDVHEGVLTAPTCPGLGVRPRMDVLGEPVASYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0I5</accession>
    <name>A0A370Q0I5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0I5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="251" mass="27804" checksum="642887528FB661F6" modified="2018-11-07" version="1">MANLGSWQHYNRDASISITLLGVFFVGLRFLSRHLGKVPLGLEDGLIVAAVLNLFVIFALDIEMVKYGLGLHQSTISMDSLITINKLLLPAEIFYCTSIILTKTSILAMYHRIFHIHRPTRIAVYILGVITIIRAISLIFASIFQCTPVARAWDKFQYPGRCINLKDTFIANDVVNAITDVVILGLLIGRVWKCRQGGGYTRPIERMVCNRSLFGDYLCVSPYSTSTGKSSVPASVQQKAVLSGSGEFKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q117</accession>
    <name>A0A370Q117_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_272327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q117"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000013">
        <property type="entry name" value="Glycerol-3-phosphate phosphatase (GppA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="237" mass="25663" checksum="8EFB8125F354D3EC" modified="2018-11-07" version="1">MSRPSGSFSAPPQVHTFDGLLSDFDGTIVDSTDAIVKHWHKIGAELGVDPKTILATSHGRRSIDTIQLYDPKKANWEYVSYIEGRIPKEYGSDAVEIPGARYFMSALDDAGARWGVVTSGTRALVDGWLGVLNLAHPKVLVVAEDVELGKPDPRCYLLGRTRLGLEHSSSLVVLEDAPSGIRAGKAAGFKVIALTTTHSLAQLQEAGADWIVEDLRSISIKGVVDGQMQLEIRNAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q172</accession>
    <name>A0A370Q172_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q172"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="129" mass="14128" checksum="AD6FA1FECD74600E" modified="2018-11-07" version="1">MDSEECELVYVGKISGRSKRWDDEGSHAGTSQSHTRLGCAQGRGRWADAPIDNECAPPSRWESVGAIDEPDNEERSPSSSEGGSPTKGIQSITKKGLNSQGIRCHSFPGIKWGRNMNDYYYFDGNGKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1Y1</accession>
    <name>A0A370Q1Y1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_11723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1Y1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="133" mass="14819" checksum="2ED34F4AC8935665" modified="2018-11-07" version="1">MQFVKAPGIYMLSSPDLGWLSAYQGALIGQSTSSFNSERHVSASSLAWVLYLIMGQHCSAPCKQLVNKHMSSSIPDRYSSRIKRQGHKHRVQHPADQNADPAWDLLQEAKRAKSHSTNTISPFPTCKRIPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3F7</accession>
    <name>A0A370P3F7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_260708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3F7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="135"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="34581" checksum="A137808C0180C155" modified="2018-11-07" version="1">MPSAGSKTLSLRGLYNFQCPRPQVQTYNKTHLPSIHGLKPSVSHRHISHQQQPLASCFVLPSQSRRNSSQLARAIGPRPGTAAETYVAYGMTQKLFEACSKQADYKIPQLSQKGAQVPKTSAGEDLGVGEGWWYEELGLVPTFSTWSQVTFLHMYLLTVRLRALPSHDSLQTYSRHLIDHFSHSAEHRMDVLHGLTSRGIRNKFLKDLFIQWRGVLAAYDEGLIKGDAVLGAAVWRNLWKASHTAPDGKDLDWSKIAQVVAYMRRVLSELSQVHEADLVFQLDRQRNGKPGIFSYSDVDQKMVDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4D9</accession>
    <name>A0A370P4D9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_280314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4D9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="145"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="34203" checksum="1EDF91518199F336" modified="2018-11-07" version="1">MEFNMNSTFAPPAAASYPELYALASQNPKLTFLEKAWWTHYAYWDNDIIATGIITFLAHEILYFARCIPWIIADALPTLFHRFKIQDKKAPPSAKEQWSCVKYILAIHFIVEMPMIVLFHPMMELFGLKYALPFPDLKTLAIQITIFFFVEDTYHYWLHRAFHWGPLYRAIHRVHHQYAAPFGLTAEYASPWETMLLGLGTIGPPLVLGYFTGEVHLMTVLAWVALRQFQAIDAHSGYDFPWSLRRIFPLWGGSDWHDDHHRYFRGNYSSSFKHWDILMGTVAGPRGKKMRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4N7</accession>
    <name>A0A370P4N7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_330948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4N7"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="45316" checksum="7CD29700933765C3" modified="2018-11-07" version="1">MIELGLSRIVRLLQQTPLTWKAIHIAGTNGKGSISAYLSHLLSTGGVRCGRFTSPHLIDRWDCITIGEKVVQESLFRQIEARVKLRDQTLGIGASEFELLTATAFEIFNHERVDIGVVEVGMGGRLDATNILTDVLVSVIAKIGLDHQFLLGDTIEEIAREKAGIMKSGVPCVVDGTNSVEVLRTLEGHIKELGIDAIFTRPDTPEYHSPSLGQLFATLHLLPHQRANMSCAVSALKLALPRFRPDIDVDALVPQLSKVEWPARLQKIVLKPLVDREEPVLLDGAHNTQSAEVLGEYVDYKLRPQGTNVTWVIAASRGKDIESLFHSIIKAGDRVAITAFGPVDGMPWVKANDPEEVASCVRSIAGIGQVQTFGEDISGAIHWACEQASGAPLVIAGSLYLASDVLRLLREAQKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P557</accession>
    <name>A0A370P557_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_279974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P557"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16530" checksum="CB49D081410F152D" modified="2018-11-07" version="1">MSSMKHPPSREAMRQILDVNVVGALSTTEAFLDLLRNSSEKRLVFVSSSTGSISRAADPSSPFHIASATEYRASKAALNMMMVLYMCRLKDEGFKVFGADPGLCATNLTGDPESLRRRNAAEPSDGGERVATVVKGERDADVGKVLGVYGVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5H9</accession>
    <name>A0A370P5H9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspergillopepsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_105318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5H9"/>
    <dbReference type="SMR" id="A0A370P5H9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017050650" description="Aspergillopepsin" evidence="4">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="27876" checksum="37BA1C63F563A334" modified="2018-11-07" version="1">MKTTALLTAGLLATTAMAAPLTAKRQAARAKRSTNRQSNPPFKPGTNDVLTLNGTKNVEYSSNWAGAVLIGTGYTAVTAEFVVPTPSVPSGGSSREEYCASAWVGIDGDTCDTAILQTGVDFCVQGSEVSFDAWYEWYPDYAYDFSGISISAGDTIKVTVDASSDTTGTATIENVSTGTTVTHSFTGGVDGDLCEYNAEWIVEDFEEDDSLVPFADFGTVTFTSCSATKDGSSVGPEDATIIDIEQNEVLTSVSVSSSEVVVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P733</accession>
    <name>A0A370P733_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_339494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P733"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="84" mass="9107" checksum="7469CAC3A5E395C1" modified="2018-11-07" version="1">MPRTSLNGFYRSFKARHLSKSNSDQYITTTEDGHAEDSASVLSDATTLAQSKTGPQKGTPAQQGPDSLDYGSTRYSMRGMSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P789</accession>
    <name>A0A370P789_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RGase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_308769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P789"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016978238" evidence="11">
        <location>
            <begin position="19"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="49812" checksum="7E4BBF5B04C6C2F1" modified="2018-11-07" version="1">MRASILPLTLFLATLAGAQLSGPVGPLVDYSTKARNQTCNIIDYGAVADGKTDISQALLDAWGNCSVGGLVYIPPGNYSLAEDIELKHGQSSAIQLDGVIMRGHRGSYQMILIRDCNDFEFFSGNSRGAIQGFGYEYLQNDTYGERLLRIQEVNNFSVHGFALIDSPSYYIVFDTVTSGEVYNILIRGVTSVGATDAIDVWGENMWFHDIEVSNGDECVTVKSPAHNYLIENIYCNLSGGTAIGSLGTGTNISDIHYRNLYMNQADACFLKTNNGDGIVKDIIWENVIVHGGPYPLAIDEAWGDDRGSVGVQVSNLTFRNWHGESVSASRPVIRLQCDSDLPCYDITIENVNLWANDSNYVVWQCENAYGDGACLSSAEGTKDLKTFTSKQTITATPSYAAPTMAADFTSNLPSTSPFAIPPMPTSFYPGATPISTLLHLQGAGGLPSAFPVSHHRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7A2</accession>
    <name>A0A370P7A2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_321689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7A2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="37250" checksum="7897862737494C8B" modified="2018-11-07" version="1">MSNQAGWVKTPYGRVQVEPVEQWVPGRGELLVRVEAASFNPIDAKIQRLDLFQSQYPLILGFTFAGTVVSTGPEINSVQPGDRVVVARWGQQAGEDPRFGALQRYALALEQNTLRLEPETTFADAAGLIANLATVVSALTIYMGLSKPPVTGTTPPIGKKILVYGGSSAVGGLAVQYAINAGYDVVTTSSAANRSMVEKRNPTHIIDHSRSDEDVIREIRENGPYEGIFEAIGSTTTTQRMVALLRETGGRFFSTSPSPGDETIPAGIVKVWAGYSETLVSEAAHQQLRTWYMEAYLPAALKKGTMWPSPALWLEGGLGSAQKALDLLYEGHISGRKVFINPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7F9</accession>
    <name>A0A370P7F9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-binding Rossmann fold oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_257520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7F9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39538" checksum="A837C3329AC877F2" modified="2018-11-07" version="1">MSSVQIAVVGLGRMGKRHVHTLLYRVPRAKVVAVCSTDASEIEWATSNQEYNEFGITVYDNYDNMLAHPGLQAVWISSSTDVHASQSLAAIDKDLHVLCEKPLSTDLAEAQSVVDAARAKPSLKVMAGFSRRFDASYRDASQKIFDQKAIGSPFLVRSNTCDLKDETGFFVRYASRNGGIFVDCAIHDIDLSLWFLDNPTPKACWAAGTLQHHPELKDLADVDNAVGVVEFWGGKIAYFYCSRTQAHGHDVCTEITGTEGKIMVNVIPRQNNTVLADKLGMRHEVQPEYWERFENAFAVEANEFVTAVLKDTEVPLPLERGIMVMKIGQALQRALLSGEVVRFNENGERLNCNDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P873</accession>
    <name>A0A370P873_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_307685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P873"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="420" mass="46064" checksum="5273006D1FF56C81" modified="2018-11-07" version="1">MVSADAEDTKQGVALPPEEGVQGWICVVGSCLSLFCTYGFLSAIGVFQTVYEETTLKEYSPSDISWIFTVELCLMWALGPIYGRILDTYGPAPVLYPCSFLCVLSLCMTSLAHEYYQIFLAQGLTFGLGAGGVFTTASVCVGQWFIRRRALAMGIATCGASLGGVVFPLFLEKVIKIVGFHGAVRYTALFIGILLALACLMVRARLPQRKWDREARWFDFAVFKQKQPLLFVIGCFFAMWSMWGPYDYLSTMAKNSGLSSSLSVYLISMITAASVPGRLIPSYLADRIGHHNVLTACAFFSGTSIFCLWLPFNYHHSEVGIIVFALFYGFASGSIVSLFMPCIAKFGKIESLGQIFGTFQLVISISCLTGLPIMGGILNQQHRTDFSGLQIFAGLSAILGSLFLGTSNYLLAKSRRTWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8K0</accession>
    <name>A0A370P8K0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_307616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8K0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="58467" checksum="2259E2876ECCC05E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9A0</accession>
    <name>A0A370P9A0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_306767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9A0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="578" mass="65575" checksum="A22C2E2316E40C07" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9B4</accession>
    <name>A0A370P9B4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_256865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9B4"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="52"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="648"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="814" mass="90393" checksum="90B2A5CCC1A7B10E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9I7</accession>
    <name>A0A370P9I7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_286045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9I7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="EMBL" id="RDK38871.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
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                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9P2</accession>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nielsen K.F."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
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                <person name="Lipzen A."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="600" mass="66286" checksum="3575DB73B7F33DDA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9X2</accession>
    <name>A0A370P9X2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_329192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9X2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="407" mass="44252" checksum="8626F4F38B85AB21" modified="2018-11-07" version="1">MGWVHNLAHPDAHNHVARVIAICLTFSISAVIALVLRLYIRLHSKRALWLDDYSAACSAVLGAAYAGIAVARLDAAAFPDANVVMFSKIQYAGGPTYILAILCFKVSLLTSYLRVGGFVAAYRWSIIGVVIAVVCNQVIFTFLLTLACNPVAKQWDASLPGTCIDTVASYYALAGTSLGFDLVIIALPLPVLWSLQLRQAQKIALMALFALGFFITIIQIIRIFTIKHLKTYTDSQPIVLWSQVEISLGVIIACVPTYGPYFHAFASTLTSSYNTRRQRRQHASQSQTMDPSRSYALSGARRTQRNQSRMLPSETDDQAEFLELGEASAGRNRPWDNSVAVTTTIGHGDGDSSSGGRSSLGSGRGRGSGEGKDGEGPLQIQRVVEVELQLYCAAVMVLGSYHIRFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAS5</accession>
    <name>A0A370PAS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24148" checksum="7A3459630C98B75D" modified="2018-11-07" version="1">MDPETDPSNPPVINYILSFLLVGVAWGFTTPFIRRAAADFAARQQQNQQQDDNNNNNNISINSNENVPLTPVTPEYTDEARPEEGGEESEEDNPPPATHQEQQQQQQQPAWMQQNQQKPPSWLRKKITTLFWTVVNLLRTPAYSIPLVVNLTGSVWFFLLVGKHELSLTVPLANSSAFLFTVLGEWYVERKVIERETWLGMALVLGGIALCVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAS6</accession>
    <name>A0A370PAS6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="11" type="ORF">M752DRAFT_278299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAS6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="28870" checksum="C0E8588DA813BE8E" modified="2018-11-07" version="1">MKALRLLRRAPLAPSLRPTPPAVLDFLTPSTLQTCRQYNSTATRQSAENPSVSQQTSGSSKPKYVLNQQQREFLDRALRVNQAGELAATLIYTAQTPQVVRSHPHLRPLMKHMYDQEAGHFDTFNHLIAKHRVRPTAMYPVWEVAATFLGWSTGMMGREAAMACTEAVETEIGSHYNDQVREILSWKAEAESRGEELDEELEEMLATFRRIRDEELEHLDHAVENDAKEARPYDPLVNVIRYGCKAAIKISERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAS7</accession>
    <name>A0A370PAS7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_58682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAS7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="183"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="306" mass="33530" checksum="91A70E7366747CA7" modified="2018-11-07" version="1">MNPFSSPLITPAEYHHNATTYNATGSRRIIPLAAYRPTLHSSFESFHLPGSKFFNLDQIRDTASPYPSMLPSPSLFAAGMTALGIRKDDILVIYDADEIGTYHAPRLAFMCELFGHKDVHILNNLRRYVRMGLPVGSGSEGIEVPVVGTGREQGDEYVVEEGDIDTGRVISFEDVKNSVLGKDQEKVRIIDARIPGRFQGVQPEMDPSLRSGHIPGAVNVPLARLLEDGDAVILATEKLRSVLMDAGALAEEDEGMLYILTCNSGVTAASLDLALRLVGAKGSRRVYDGSWMEWTRRVGDELIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB68</accession>
    <name>A0A370PB68_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of volume decrease after cellular swelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB68"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32379" checksum="494B433FEC848AC0" modified="2018-11-07" version="1">MESIAAPPDTTTFIPLAEHQSRTPSSFHSGPPILYSHHQNCKLVLLEREALAVPALGALREASTANGTAEEEGDKEIVIPGVNVWVTSEKFLLHNPTTNTGLSIPYPSISLHAIQRLQLPSSEDQVQGLYMQIANPTTSSYTSADDEEDALTVTVVPETPTQESSSPAEEGDEKPETPTQTLYAAVSACSNLHPDPVEPGDEDEDDYEGEEGAFQSGLVSMGSAEGGLPPPVEGSSGWITAENMHEFFDEEGNWIAGGEEPTLPLGPGAGTVRQREEDEGAVDGQEGVNGDGNGGEETKWRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBC4</accession>
    <name>A0A370PBC4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCCH zinc finger DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_338340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="46742" checksum="4A814963BEF4C11C" modified="2018-11-07" version="1">MIDLLEVKRRYEAVLAVEDSRDKILQNLFAQVESLQKALQNTLGDAKFQELKKYKTEYDDLRLDQAKLSFVSVLVDGDCMNFNDALIRQGYNGGRKAAMLLRKSVERHIRDIDPQASPNIQYRIRVYANVPGLMKTYREAHILRSNEALDPFIRGFNMENSLCDFIDAGNGKECSDVKIRAMFEQDILDVHCRRIVFCGSTDNGYARILGSHQGSNRISLVQGAPFAWEMEQLASEFQTTSFPEVFRSTKLPSRASSFSAFKTASANSSPSSSPTSLSTPSTPKRNYATIAKSNLQATSPTRTNRSKRSTARASESILHPGPAAKTITKDYEGQNTAVDIIFWESVPLAMSAGTDTDADWDLGMFMTFGVLRERASVRMISGVRIPSVSVDISVRGKISKGIAVEIASFPSLCMGLISRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC01</accession>
    <name>A0A370PC01_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_338045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="332" mass="36788" checksum="3CC961E520D90469" modified="2018-11-07" version="1">MTLSTKIITVFGATGRQGSSVVRSLVQNPTFHVRAITRNPSSSKAKELASLGAELVKADGFNRQELQHAFSGSWGAFVNTNSEDPELLSKGLNDADLGSNIIECAALSGVQHLVYSSGLAITEMTNGAVQCPGLDLKIQVERQAYTTKSFKSVTPIVAAWFMENWLEPDYADLFGGWPTFPDSEGYLTYKTPFWGGKEDFPWISMKDDFGDLVHGVFVNPLRWNRRLIQGSSDIVSSAEVVNTFVSVTGKKARYEVLADPNDMNTKGEYWREQERDVFVYSQFRDGEYFGNGPTEIQTAAALKKAAFKAKGGKGRETLITVREFMEREFAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC96</accession>
    <name>A0A370PC96_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Translocon-associated protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_278236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC96"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016960310" evidence="11">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="28313" checksum="68D062C6451B8881" modified="2018-11-07" version="1">MGRFGFLSLALLSVQALIGGSLAADAAEKEDLPETQLLSVTAHASFPASEIFGVKLVNGYPTEALITFANEEESPVTVNFIGGSLSAVEGESSQIVRNLTAHRYSVEIPAGQQESVSYSFATEMHPQDLLLTLASVISDTDGNLFTLYAYNGTVSVVEPETSIFDPQILFLYFFLLACFSGVVYFFYTVWIAPYFPQKRRAGKGPEYKKSAGASKKEAPVEAPSSPAVSSATTYNAEWIPAHHINRPEARKVKGSAKAKNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCP2</accession>
    <name>A0A370PCP2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_277855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCP2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="528" mass="58243" checksum="34F51B2264723BBC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD23</accession>
    <name>A0A370PD23_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_285445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="389" mass="43660" checksum="B48F2B720ABB29B4" modified="2018-11-07" version="1">MAHLGSAALSLIGPYIGLLQEKILYKPEHAVPFTVHSSQVRHVMEAKDLQPLGQNEPIVEPDESENAQKQPWTKPPPDPEPNSQSHSDSDQASINSYETHQLDIYEENNRRYPNDSYHMPNDEAERTRLNIVHQIYLILLDGHLTAAPIVTNAPRILDIGTGPGDWAIEMSHAYPHGTIIASDIGVFDNALGHVDLPNLSFYLDDARDEWAYNIPFDLIHLRGLSGAFPDWSFIYQQAFEHLAPGGYLEVADTDFAAETMTTIPQNSYLRLFASALRSADYSAGYLRDLSHLQPALFRAQGFIDIDVREYTFPIGLWPESPHDRTVGKMGLIALLEGLESYSLRALTTTYGWLAEEVRELCDQVRAEILEGVYRISARVKIVTGRKPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDE5</accession>
    <name>A0A370PDE5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_303751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="259" mass="30349" checksum="3F49335281ED3CB6" modified="2018-11-07" version="1">MPPFPLLFHSPDNWTSNHLETLRIERHFNASLDEIIGVDHIPKDGDEGWTLRAPFMSLSWSCSLIAEFESLVTEFAEPTENELKNLRGTARVRYRRNIFLPVFKHLCEMLNSDVFFDASRQAVLSFIEIILRRVHLEKPMLHVSKPYHLKWQVAKDGDYKFRDQVAQLLLQKAGAHQRNQSRRAFVIFMDSTNFQLTMADPHRDYLDALLHGERPHQNLDLYHSEFYNLCNRRRRKEALRVMLGLIRLLGADGLPRGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDV6</accession>
    <name>A0A370PDV6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="130" mass="14405" checksum="5DE08E28F9C52474" modified="2018-11-07" version="1">MAAPYRLIPEALSVAKRSAEIGSVAAEFEIASLAKHQEYLSKACHHANNGRSEPGTIWSVADVMARELMWLERFNHAAMYGTEHHCDQKDLNTSADYICTLPNEFLSLDLLQQLSACVQVTVTQLKLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ3</accession>
    <name>A0A370PDZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_254468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="36517" checksum="027A6ED959B9EB16" modified="2018-11-07" version="1">MSLVSGPGRAAGIESSLNLSVERHVDYIKNLDSRRDELEYWLTEHLRLNGVYWGLTALHLLGRPDVLPREDTIDFVLSCQRENGGFGAAPGHDAHMLYTVSAVQILVTLDAVDELEKRGLGGKEKVGSFIAGLQDKDTGAFMGDEWGERDTRFLYGAFNALSLLGLLHTVDVPKAISYVQQCENLDGGYGIQPGAESHAGQIFTCVGALAIAGRLDLVNKDRLGGWLSERQVENGGLNGRPEKLPDACYSWWVGASLAMIDKLHWIDSGKLSAFILRCQDSEAGGIGDRPGSMVDVFHTHFAIAGLSLLKFNGIQEVDPVYCMPKAITQKYLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ8</accession>
    <name>A0A370PDZ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_337870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="89" mass="10020" checksum="0493B92EAC007602" modified="2018-11-07" version="1">MDAQTQVDISKLNDADKNELSQMLANEQQKATMQQTVHSLSDVCWKKCITGKISSGRLEQPEESCAQNCVERWMDSNLAILKHLEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE03</accession>
    <name>A0A370PE03_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_43260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="273" mass="28645" checksum="70A50BD75C14C2E8" modified="2018-11-07" version="1">MPLPQILVGKVAAITGGLTGIGRAIALEYLRHGAKVAVNHLGGSKEEPLIEAMRKDVSEIIGSNNNSEQSSSRFILVAGDVTQPETGREFVAKAVEAFGRLDVFVSNAGVCKFEEFLEVDPPLLGHTINTNLCGAFWATQAAARQMALAQSPPGGSIIGISSISALVGGGQQTHYTPTKAGVLSLMQSCAVALGKYGIRCNALLPGTIRTQLNDEDMSDPVKRTYMEGRIPLGRLGQPPDLAGPAVFLACEELSGYVTGAQILVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF9</accession>
    <name>A0A370PEF9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_277303</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF9"/>
    <dbReference type="SMR" id="A0A370PEF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479144" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="174"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK40566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="391" mass="43478" checksum="85EEB17883035AF0" modified="2018-11-07" version="1">MKLSIALALGATASTGVLAAVVPQQEPLITPQDPPTHHHQEKFLIELAPYQTRWVTEEEKWDLKLDGVNFIDITEERNTGFYPTLHAGSYVHYPPTMKHAEKVVPLLRGLSKDNMEQNLNKFTSFHTRYYRSSTGIESAKWLYSRVSDVIEQSGAAEYGATVEQFAHSWGQFSIIARIPGQTNKTVVLGAHQDSINLFLPSILAAPGADDDGSGTVTILEALRGLLQSDAIVRGNASNTIEFHWYSAEEGGMLGSQAIFSQYKRDKRDIKAMLQQDMTGYTQGALDAGRQEAIGIMVDYVDEGLTQFLKDVTTEYCGIGYIETRCGYACSDHTSASKYGYPAAMATESEMENSNKRIHTTDDSIRYLSFDHMLEHARLTLGFAYELAFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ1</accession>
    <name>A0A370PEJ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_303274</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000017">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016488658" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="363"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="57265" checksum="197885B08A8391AC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEZ3</accession>
    <name>A0A370PEZ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_218440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="85"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="60875" checksum="06A66ACDF795770C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF03</accession>
    <name>A0A370PF03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_37236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF03"/>
    <dbReference type="SMR" id="A0A370PF03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="283" mass="30691" checksum="9EDB2D64C8371C58" modified="2018-11-07" version="1">MQPTLAPAPHPSMQTSAQDHADQVLHDQLLAAHQHLSHPQQARPQGPTAQPPHMQPNTTSPRDQNNIDPAISGAAMLSGPPQTPPQPEPTGQESPKTYGKRPLSTSKRAAQNRAAQRAFRQRKESYIRKLEEQVKEFDNTNETMKQLQAENYQLREYIINLQSRLLDSQGEVPELPGNIDLNQPRNDISVPPPGAPAATGPAPGPGGAPQQMQVPNPGAATNEDMNSLNRIAVAGLGMRKHPNEEANFLGNNFQARRPRNDDGQPDGSEATKTEPGHGLPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF09</accession>
    <name>A0A370PF09_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_328154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="265"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="428" mass="47646" checksum="D007BAD958B42E47" modified="2018-11-07" version="1">MVSLWPFRAEDTSPASFEKALAALSTKITRATARLDLHRQHARRFKALWTLYTTFAYLLYSIIIALVLGWQNWGITEYGAIIGGPILIYLIRTISTRYYDYRITKTQAYLDDLHKQREKTIEDLKTATRWNSTQQLLEKYGGESPKPARSNSVKSGDAKRNKSEGAKRKQPSQQQQQHVQRTGIPPPPTANIRRPAPQQFPSSPQPPSTPPVAFQHHQQSPHVFPGQQQLQQQSAPNMNVGLEEPGFAPNAFSSTSTQYVEQSHWYDRLLDVLLGEDETQPKNRLALICSTCRLVNGQAPPGIKTLEELGRWRCGNCGAWNGEESEAKKVLAGIRKEQQQQSSNISSGSVDGTETRSSVGGDVTDDGVMVAATGSEDDQLESQSEGAETSEEQVEQVAESENEEEEESEPQPSKRVTRSRAKGGKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFB6</accession>
    <name>A0A370PFB6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="526" mass="56759" checksum="8B81CC0D246554C7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFC1</accession>
    <name>A0A370PFC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">M752DRAFT_277533</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFC1"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000096">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="362"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK40880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="52070" checksum="FD0D12880424A368" modified="2018-11-07" version="1">MNGVEQTCASLRTQIAATEAKLADLKRELEIAEQAAASHKQNAADAEGGSERRWPLLDEEYRRYGRQMIVPQLGIQGQLKLRSAKVLIVGAGGLGCPAALYLAGAGVGTLGLVDGDAVESSNLHRQVLHRTRNIGKLKVDSAIEYLKELNPHSKYIAHREHLAPEAAPEIFSNYDLILDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLMVLNNPPRPAGDKTGGPCYRCVFPKPPPANTVTSCADGGIVGPVVGTMGVLQALEAIKVITADETTTPPPPSLHIFSAYSTPLFRTIKLRSRRPNCAVCSAEASVTVDTVRSGSTDYIFFCGTTGPENLLSPEERITPLEYRTRHHDKEEKEPMIIDVREKVQYDICSLENSINIPISTILASALSSMSNGDSLADGVPALPSWVPPDVASSQSTDPVYVVCRLGNDSQVAVKKLKELGLDQGGKRVVADIRGGFRAWKEQVDPEWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFW7</accession>
    <name>A0A370PFW7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="16412" checksum="D0E0D3F75BF025EF" modified="2018-11-07" version="1">MENALGSYPFGVPAPSETSLTPDLDNEAPGGITPTASPKVGGLQEPVNHVDTGELNVTGTSRTADSLALLRRKVEEYEQLLQDLEKKVDKNAARSIRKAHRGSDTPSPTDFDSDSDSANSSIVSLSALELVEEDLNRSERTVATGFIGKNSEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG19</accession>
    <name>A0A370PG19_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_267422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="228" mass="25521" checksum="6868036206745B07" modified="2018-11-07" version="1">MSPRLVQPDCYTNTDYEIGKRLFNVYMALMIVHTSPNGRTDDSLVEADRFIDSKAYDFEAALVAIKSLNLDLPRTNKFDDESCEDYIYKILGFVRLSDSREDFVPLLTKLHVQIPTCSADTGISTTAYKESVLEETAGRYVSPTPTQCSSNASDEPRIWKYTSRLWEDGSNHGVTPNVEESCLSSYPPKFRITISYRGMQASGEGKTKKLAKHIAAKGVCHQLGLQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG36</accession>
    <name>A0A370PG36_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="242" mass="26652" checksum="1627F9060F7484B5" modified="2018-11-07" version="1">MARRAWGIARELNSHDWAGYIALKFLAFGGENLSQNYQAYETKYEASRRTAVVKQRKVVSLSPFDRSVRKRVNLPVRLSRHAPDSSPGWVLMPTPCRVLTVHAVAKVSIHAPRQIVRSIDDLDPSYISADFLLVYFVAAEFTELSLLSVVVRGGRCQQSHLPRASSSRMPPGVMRLPAGLTGCGNEWPVGNQRLLAAEQLDSCGLMQDNSTDLVGAGATDGGRNELLSSFVRRAVFITQLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ7</accession>
    <name>A0A370PGJ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAP family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_336522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41175" checksum="CB81A68557EB38C2" modified="2018-11-07" version="1">MSAEEANTSLLERIQRPEVSKETAKKISLVEEQFARAEVEQLRQSTLLLRPLFEKRNQVIAEPDVRDTFWTRVMLNAPAEVEEYITMTDATILASTLKNLTVERFEIDEKGQGEPRSFRLTFEFRTGDENPYFENEKLVKTFYWRKQVITTPKGHKRTWDGLVSEPVRINWKKDQDPTKGLLDAACDLAEAEKKGGDRKKLPEFAKVIEKKDEIEAAEDQEMGDDEDELPEDGPGGMSFFAFFGYRGSDVTAEQSQAATKEDNERFEKLLKGEPVEGEDEEDEDDEDDDIEDEFDDIEVFPGGEELAIAIAEDLWPNALKYYAVTDQAIEEVDFDDSELDISGDEEEDENDRPRKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHA4</accession>
    <name>A0A370PHA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_302015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="523" mass="58704" checksum="8C9B38369FF91E5F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHS3</accession>
    <name>A0A370PHS3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_276478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHS3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="341" mass="37465" checksum="AAA6587FF3C12469" modified="2018-11-07" version="1">MAETTNDTAATAAAAADPQPPVVTFKKRGAKASQNIRKRPAPPPVSQDNDSSDFSSSEDESGHRIKRRKNKGAGVVSASSATTKPVDREPAATATGDGKVQLADTNDATKHVDWFDEDSKDARSSKPQSASNEPQMPDGTYRGLANQTSFIKKNPNAPNRSFGPIKAATNIRTITVTDYSPDVCKDYKQTGFCGFGDNCKFLHDRSDYKQGWELDREWETVTKGKQLKGTVVASADRTTTENKDDDEEAMLEDIPFACFICKGPYREPIVTKCGHYFCEQCALQRYRKDPSCAACGSATNGLFSSAKRLKKLLERKRELAAKRRQEAIEAGEEVSDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHX6</accession>
    <name>A0A370PHX6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of ploidy protein mob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_19976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="218" mass="25132" checksum="0A5E920DEE83F79F" modified="2018-11-07" version="1">MASFITTINARTRAPFKPRSAAKGTTSYQLRQFAEATLGSGSLRKAVKLPEGEDLNEWLAVNVVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMSAPEYIEHLMSWVQSSIDNEQIFPSRLGVPFPKVFPSLVRQIFKRMYRVYAHIYCHHYPVVVHLGLEPHLNTSFKHYVLFIDEHRLASGKDFWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI14</accession>
    <name>A0A370PI14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_20477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="15920" checksum="C1B92C86205C5FAB" modified="2018-11-07" version="1">MGQGRSARVAAAAQAIHGVFEPGRFLLFPMTGWCDGQDPKSGSESAEEIATSSAKHGIADGNCPPPAHVTSDSPGIASLRSSPSKKSHPPPVAPAHFPPPVLSFLFLSFPQTKDLDLLGCCCDCCLLSILPRGGSSPPVLDPLIYLSVSCPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI60</accession>
    <name>A0A370PI60_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_276576</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="221" mass="24902" checksum="54D03FF3EB58E8F1" modified="2018-11-07" version="1">MGSENASNPLWTTQSVLASLPHPPEENSASPIPFFHLLERLKTTKREGWRRFGINSGESISDHMYRMSVMTMLAPPSLASRLNLPHCMKMALIHDMAESLVGDITPVDRVDKTEKARREAAVMDYIANNLLGGVPGGMLTGQEILKVFNEYEANETLEAQFVHDVDKMELLLQMVEYERANGIDLSEFCHVANKVQLPETKEWAATVLQEREKFWKSKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI78</accession>
    <name>A0A370PI78_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional fatty acid transporter and acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_336286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI78"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000055">
        <property type="entry name" value="Bifunctional fatty acid transporter/acyl-CoA synthetase (FAT1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="636" mass="70693" checksum="2E48FCF12A01DF07" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ23</accession>
    <name>A0A370PJ23_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_300199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="375" mass="41056" checksum="C93CF8123A4C8207" modified="2018-11-07" version="1">MVDDAHQKLALGVVVAFPVLGGIAVLLRIWSRYLTRSRLGADIKTNYVGIHIWDIPKDYDIKQGLIWNFANQLIYNPCLTMVKLSILMFLRRLESQSRLVNSLIWSTMFITVALFIAVLFVDIFQCSPVAYVYDFSISKGSCINQGAFYVATAATYLFTDLLVLSIPIIITWGLHMPLRRKVAVCVVLCMGAVATGVGVWRIVLLAKGFFPTHPVYDATYSIGFCSSAVEVHVAVLAACAPCLKAIASTYLPRLLGSSRRATYPSTGRQYVPTSTASYSHRSHVKISAVRGDASAAFEMVTPQLPIPGVEEAAHKREMRKYHPYAEADDTSLSSEDGAPTTGIVKTTAISVRYTADSNLESGGEGTREGSVERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV6</accession>
    <name>A0A370PJV6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="61084" checksum="32E499812FD88F9D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKF5</accession>
    <name>A0A370PKF5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_318889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="496" mass="56494" checksum="500D43F653A7A67F" modified="2018-11-07" version="1">MGGTGVPTFEPKMRSSVSNYPSWGALTPRAFSAAQPAHPRPSLRRAGGSKAFPSPRLGYPLVGDALAFLNRPVAFVQDATRKCGPIFHVKILFANIVYLRGTQLNRMYVDVKEDIWSFGGGIGIFLKKIAIPGYFDHFRNLVGSLNRGINRKVTLDRYTELAGEEADKALLKWSQQSDVKVFEEASKYVHRVIVRTLMGQDFYDEHIDELYDLLHRMEDEIGHPLNLLLPDWFPHPPARRLGKARDRFAEIFAQQMAIRRQNPEKWKGSLDYITYTLEDPRTAHLQEYYPSHHTVLMFAAHTSTVASIAWTAMELIRNPEYVEAIRQSFQTNEDVHQSPVLLACVKESGRHYSGVHMWRTTHRPVQLEDGYTVPENWVVCTSPYLTHHDPEIYEQPQQWLPERWLRPTARLQNLNNATDAAFLQFGAGSHRCPGENMAGIIARELVSRLVKNYDFQWGSQGPAKIDVSNMDFSKVGSPWLQGDALIRIQPRKSAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKH3</accession>
    <name>A0A370PKH3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_314983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="59042" checksum="E3354B45C336F060" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKH8</accession>
    <name>A0A370PKH8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_250599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="320" mass="34990" checksum="74A6F13CE87966C2" modified="2018-11-07" version="1">MTIFRSSAKASESEPQYGIKVLYDSNEAEVDIVFVHGLGGSRDATWTIDDVCWPQALLPHDLPKTRIMTFGYDSRVVSFTTALSQNGIVGNAEDLCAQLARFRASSPERPIIFVAHSLGGLVCAQAVVAGNRSSPSDNTQIISQHVRGIAFLGTPFCGSEIANWMSRLNKVADYIFESNKANVSDLKSKSGTLQLLIEEFANVLRKRDNSDDSILTTFFYEQLKTQGVMVVDRNSATIPGRGDMISIQADHKNICKFRSREDDEGYGLVLGALRKMMVEAPVKQKSSSPVFNFNNAGASINNQAGQQTINGGMNFGTFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKN2</accession>
    <name>A0A370PKN2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_250649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="97"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="51814" checksum="6FBBF662F5F0CCAE" modified="2018-11-07" version="1">MAGRISQCARRLGMLQAKLQLACRHVIPTPTPYLGNITRASYQTIRYSSQWKSPLTVFPTTDALIDPSIEIEEETLPTYHPEKYYPVQQGEVLDNRYQVLAKLGYGVTSTVWLGRDLRDSKYVVLKIYVTAQEKNHELEIYNRMNAVEVEHPGRDLVRRLFDHFTVTGPHGPHVCLVHEPMGMSADTLLQKYIPGNTMTLDEMKTCIRQLLIALDFLHSAARIVHTGKDLQLKNLLLPVPNTKTLETLEEREVNDPSPRKILKDRTIYLSTVYNPGGSGLPVLCDFGEARFGDVENRDDIMPNMYRAPEVVLKENWDYKVDIWNVAMVAWDIVSPRHMFDGRNADGIFDDRVHLAEMIALMGPPPASFRERCKLAYVFWDEQGNWKDLAPIPDISLESLGADIPGENKEGFFRWLRKALQWNAEDRPTATEFLFDEWLMEGLRRPNTEDAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKV1</accession>
    <name>A0A370PKV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroflavonal-4-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_251652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="36936" checksum="C36071B7BCEA4E6F" modified="2018-11-07" version="1">MSLPSPPPLVLITGATGFIGSQVALVSLQAGYRVRLSIRRPEQEAVLRARYPDFSNQIETIIIPDITVRDAFKPALDGVDHLIHLASPMPGAGSDLQTGYIDPAVKGTESVLFSALGFPRIKKVIIVSSVLALTPPMSLCEKDVLVRDNTNEVIPIDLTPDLLEGPFGHGFKYSISKISAHQATRDFMASQNPHFTLVTFHPSFVLGESLIQEAPEKMDGINAMFWDSLHSGKPTIPNAWVDVRDVAEAHLRALQTDIVSGTEFILSAPAGSWERVGDLVRRKFPSVRCQLKGPIEGGWTVDTTAAERILGMQWRGQDEMVEAVLEQQLKLREAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKY9</accession>
    <name>A0A370PKY9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKY9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="228" mass="26335" checksum="1FC1C7556968AC38" modified="2018-11-07" version="1">MTSLQPIKLFWRNQVPNPSKVLIILEELNLPYESSWVELDGLKTKPFTDVNPNGRVPAIIDPNTGLTLWESGAIVQYLIDTYDKDRKISYATFPEQYQLIQWSYFQASGQGPYFGQSAWFNIFHEKIYGESPESAKVRYGAEVKRVAGVLDSVLKERDWLVGDKCTYADLAFVMWNTQIAFFMGSREGDQAWRPEEFPHFKRWQEAMLARESVKKVMGVLMDKEVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL17</accession>
    <name>A0A370PL17_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative arp3, actin-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_275987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="439" mass="47664" checksum="51EC3714851654BB" modified="2018-11-07" version="1">MASQTPAVVMDNGTGYSKLGFAGNDSPSFVFPTAIATKAGAGSAGSSAAGRPPVANKPSFLASGGGAGSHLSAKRGTEDLDFFIGDEALAAANGPGYAINYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAEKVKEEYCYVCPDIVKEFARYDREPDRLLKHTVTSPNGRTVSIDVGYERFLAPEIFFNPEIYSSDFLTPLPNVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIRASEARSGGARSGGLDVAVVTHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM14</accession>
    <name>A0A370PM14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_154399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="519" mass="55807" checksum="983DCFB3DFAC03C3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN89</accession>
    <name>A0A370PN89_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_190680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016952827" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="45245" checksum="18F0D16D10968BE5" modified="2018-11-07" version="1" fragment="single">MRSDKLLVLAGLASYALALPTKDLDPRTFGLVAEILTDLGEDLTGFIEALLGGGVKSSASLLTGISAQAAAVLEGGALGCTAGKIEASARAELAAWIRAHASFDASLKSSLLAWCEGEDSATLSVDVRAGLALFIPTCAEVAAKGDIYVTVDGIFSVSELEAAVVLSSSFQSTLSTFLSGSVGVELDADIKAGLSLCAGGGVVADLASDIEASLKVWLSGSECSLSASLKAAVLAWLEGKASVSGVVTIGTVPTAGLTTVSVGAAINALVETSGALTASAQAYLSAFLKSSLAADIEADVKVVLEACISGKLATSVSADARAALAVWLSGDSCQLGVELKAVLYFWLSFALSGDVTVDLSTDIITELETFITGTIDTLIGVNISGVLSLLLSGESLASLSLESRAELSAVIGGCAGVDISSSIEIIVIEWLTGCSIPGGPSIGSGSGSSSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNN0</accession>
    <name>A0A370PNN0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_264704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNN0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF41">
        <property type="entry name" value="SFGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="571" mass="64575" checksum="F7A17FFF9C941D72" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNT9</accession>
    <name>A0A370PNT9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="37484" checksum="B864A0CCE6216B58" modified="2018-11-07" version="1">MMLDKRSPYQEGSLWYYAPSQGAPISFAIMFAVSGMVHIYQCCQYKSWKVTGLLPWSALLFTAGFITRTIGAFGQWGNVGIYIASTVLLLAAPPVYEGANYFTLGRILYYIPYHSPIHPGRVFTTFVAVGVVIEAITGNGAALVANSEATEGKRKTGEGLLKAALILQLVLMAAFVALAARFHYNCSRGGVLNHKIKRALYVLYCSCTLITVRTIYRTVEYFSAASLNVYSGNQISPILKDEWFFWVFEAGVMYLNTILLNVCHPMQWLPRSNKIYLATDGVTEIEGPGYDDHRPVILTLIDPFDIVGLIKNKGRQEKYWEAGPVGKLNKDTPGSFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV8</accession>
    <name>A0A370PNV8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="17">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_232133</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 17">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16 17">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="17"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000006">
        <property type="entry name" value="Crossover junction endonuclease mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 17 20" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="19">
        <location>
            <begin position="283"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="583" mass="65222" checksum="86E8C78D29A89218" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP37</accession>
    <name>A0A370PP37_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_143766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP37"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="231" mass="27592" checksum="8E70A3CD3439480D" modified="2018-11-07" version="1">MCFWLDEMEYWVEVDERGPMLCHRREQRGDSSSLPPNVYQQGYRPIHCDRQYNTTLQTRRQKYNTGDNPRKRVYLVPKTELLELGKEAWLERRRKHEQLQESCRQLMKRQERDEEYRQAQCQPGETTQQHNMSLYNHTDDQPAVRRSATHSARYLYGPTADRVEPRTNAVIDYDRSKDKYPGRSQWYGTAPKSGTDAHPSSYSPVMGYHDRRYEAYQTHNYAQARDNGAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPA2</accession>
    <name>A0A370PPA2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_264900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPA2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11902" checksum="A434684B56A9C7F7" modified="2018-11-07" version="1">MPKEKTTRKTKPRGTERRKKDPNAPKRGLSAYMFFANDNREKVREENPGISFGQVGKMLGERWKALSDTDRRPYEEKAAADKKRYEDEKASYNAAAEEDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPG3</accession>
    <name>A0A370PPG3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_150358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="102" mass="11404" checksum="4B532366F2862F9D" modified="2018-11-07" version="1">MIQGQGELNRIQPDPVRRTRKGTPKKDPIKKELAGWREKVEAGEEHTGKPGRRKFRGCGIPSEVLGRWEPKPAPKLNGWWIGGLVDSPQQLGRCPGDQIRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ63</accession>
    <name>A0A370PQ63_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_137933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="21167" checksum="DCD4025FC2A5B2A9" modified="2018-11-07" version="1">MSLITPPPITIEDLHAFQAKHFPGSLIAQTPQPQAVTNTNLPEEYTSHDYEEQYDWNEEYEEEDEDLGYYPDGVKRTLTDEQIRIFRHSEIHALRREKELREEEEADAAAAEAEAAAERAVDAGADVGADANAKTDAAGTEQASKSRVEGEDTDVKMDYGDGGVSNTASTSNQTSRPVPQFTGRRIISYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ68</accession>
    <name>A0A370PQ68_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_138833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="850"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1570"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1572"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1593"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1634" mass="183334" checksum="8D60E34E5820A3A5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ88</accession>
    <name>A0A370PQ88_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_274711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ88"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="82" mass="8894" checksum="D13640C2C1367310" modified="2018-11-07" version="1">MKSTTTTTSSARLQNDFGADLWVKNPPKHHPTAGRGLFAGLQDTKNYNVESGWAKRSNVESQGLLGSLLSRFIGGSYKPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR85</accession>
    <name>A0A370PR85_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_247231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="548"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="415"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="732"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="868"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1263" mass="144220" checksum="CDC6498196F952F2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRG7</accession>
    <name>A0A370PRG7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_290858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRG7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="16950" checksum="14186E3287707E9C" modified="2018-11-07" version="1">MIKADTVENIENSIFQGSCLCTAVRFSVQGNPEKVFICYCQDCVKNSGAPYQLCAKYHRSQLHIEGSGDGYVGTWVVTPTTSGAEKHKKFCTQCGCTLWTVPMNHAGENVIVRAALIDDGLERFAPQVEFFAGVKPSWVKSPDNIRSFVTMPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRS4</accession>
    <name>A0A370PRS4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_324841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRS4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="171"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK44852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="439" mass="50353" checksum="C1D80EA086FD8EEA" modified="2018-11-07" version="1">MAIRRFRRITILASLLGVFLLYHFLSIRPELYTRSATQLRTPQSTPQSAPNEPPECPPLEGIEDVLVVMKTGVTEALDKVPVHFQTTLRCVPNYIIFSDFEEEIEGVKIHDALRTMDSTVRDTVADFNLYNRLREQGRAGLESADFADEANSNIGKPNNPGWKLDKWKFLPMVQQALTYKNNAKWYVFMEADTYFSWPTLLEWLSHFDPKEPHYIGTETQIADVIFAHGGSGFVVSNPAMQLASNEYATRTVELNEYTDWHWAGDCVLGKVLADAGVPLRYSWPILQNSNVGELDEFAKGFYRKPWCFPAVAFHHLTSHEIRDLYEFEKRRRQQTTSNVLLHRDVFKELIYPELSNVRDSWDNLSDEEHPAITDFHECKTLCSSSRSCAQFVMRDGICFTGETPRLGVRNPTARSGWILSTIEHMMDHAPRCPHPDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS15</accession>
    <name>A0A370PS15_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">M752DRAFT_274280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS15"/>
    <dbReference type="SMR" id="A0A370PS15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="28630" checksum="FF623A51DEF84B5F" modified="2018-11-07" version="1">MAPITDEVVNGLKDTIGKLEARVEELEGRLSNQVKPKSVAEQMRIILMGPPGAGKGTQAPRLKEKYCVCHLATGDMLRSQVAKKTALGKEAKKIMDQGGLVSDEIMVNMIQSELDNNAECKNGFILDGFPRTVAQAERLDDMLNARQQKLQHAVELQIDDALLVARITGRLVHPASGRSYHKIFNPPKEEMKDDVTGEPLIQRSDDNADTLKKRLGTYHAQTAPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSK0</accession>
    <name>A0A370PSK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_133578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="145" mass="16220" checksum="3CCCE902B95B37DE" modified="2018-11-07" version="1">MPNFETKRPPSSLLIPKKRPLKTKSSSSSSSLSKTYPTEKHTPSLYFTSTSTEQEPQTKIVNKDKGASATTTTTEFNFSLPPQPFLDPGCWERIRASSSSRLGGEGGSGGRNALQLNEKEREEERRRRRVREAEYGGMAVRGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSY5</accession>
    <name>A0A370PSY5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_117282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
            <begin position="192"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="385" mass="42514" checksum="C3FE859605D2D516" modified="2018-11-07" version="1">MHISQLYTYPIKSLQGIPIPSATFTRTGFPYDRHFMLLKVLPNGEYKNMHVPHFPEMSLFYTDIIHGDDNKKASESESSRIEVTYRPPPTADQPQSQRRLEVPLVPNTAGLKEVEVIMHQSPTKGYIMGEEYNVWFSECFGYQVVLVYLGGNYRGVLGSFAPEKSAAHRGTQGWWRRHGVWGLGTGLVGVMMLLSWVGMSMGLLGSIGATGAAGAVFWYGAGCKNKKEEQITFADTAPYLIVSRTSVDDVSARLAGDEEMDVTKARPNIVISGAETAFEEDFWAEVQIGEHGSAKLLLTANCVRCQSLNVDYATGKMGTGESGTVLKKLMKDRRVDKGAKFSPVFGRYGFLDAGSDGRTVRVGDAVVVARRVKERMVYDWPGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT01</accession>
    <name>A0A370PT01_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_333198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000477">
        <property type="entry name" value="MFS monosaccharide transporter (Hxt8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="54001" checksum="4960CDE072E82934" modified="2018-11-07" version="1">MAVWFTIGVALFAAIGTFLFGFDTGIATTTIAHQSWINYMNHPSNGLTGAVVSVYIAGEAVGALTQTAVGDKLGRLRFMELLCVVVTIGTVIQTASVNIGMFLAGRALAGYAVGGLVATVPIYLSEISDPRYRGLIGGISGCGISFGTMASNWIGYACSYAPYGPVQWRLPLGIQIPWGVIMFFGLISFMPDSPRHLIRKGNVEQARVQYKRIRRDLAADELQQEFAAMVAQIEYEKEREITSYKDIFRLFRRRALVSIAVQTMTSLTGVNVIQYYQTTLYKSLGIDSHTILALAAVYGTVAFIFNCLTTKYLTDQWGRRKMLLSGLGGIIIVEIYAAVMQREFQNTDNRVGKGFAILGIYLFVVAYYGMLNSTTWLYGAEVLPIALRSKVMGLAAASHFIVNVAITEAGPSAFANIGENYYYVFVACTVFFFTVAYFYFPETKQRTLEEIAASFGDKVITSDKQDDGEDEDPDAKCDSQRVEVVYDERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT11</accession>
    <name>A0A370PT11_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="70" mass="7718" checksum="5D9A500D945F803C" modified="2018-11-07" version="1">MRNVFRRVIGDGGDELPFCIASAPRSIPGTIVHPCEEYSVVDGSTYTGQYESMSGDKANKLRDFVSFDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTK3</accession>
    <name>A0A370PTK3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase/carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_311629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTK3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="29453" checksum="22BE337D01D5A3D9" modified="2018-11-07" version="1">MNTNFPEPHVHLPQGPHTHTAVLLHGRGSNGREFAEELFSSSTSTGQNLPSQLPTWRWVFPTAKGRWNDRFQEDLCAWFDAHSLDDITEHQESQIPGLQESVSYILGILEREIELLVGRTTHVYLGGISQGMATALWSWFCASCRVKGRLGGVLGFCGWLPFAERFENGDLDGGRRIVELCSSVAGASVGEDMRVLHTPVLLGHGTDDPMVSVQLGRQVVGIMKRAGMEVEWLEYVGAEGDGHWIKAPEGFDAILRFLQSGSGGINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTL2</accession>
    <name>A0A370PTL2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_333349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTL2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="442" mass="48491" checksum="9DB96247F6FFDD63" modified="2018-11-07" version="1">MTSQSNNSPPTDLDNALTHYTSLYRAKNPKSFEAIQSASNSIPSGTSRGVLIHAPHPLVFRGGHGCYLTSLDGDEYLDFVSEYTAGMFGHSHPAIIEAIHSVTQQGFTLGGVNSKESELAQMLVSRFPSIDAIRFCNSGTEANMFSLGVAVTYTGRRKVLPHTLVSWAGLKLKHPQILVFKNGYHGGTLTFGANTALNLPHDFIIANYNDIPDTKAKLTSDIGAILVEPMQAAGGMIPADIAFLQFLRDEATRLQAVLIFDEVVTSRLSYGGLQERYSIIPDMTTLGKHFGGGFSFGAFGGKREIMRLFEPGEKQSLFHTGTWNNNVFSMTAGVVAAKLMSREELERANDLGDYLREGLRRIFEDKRPDLQVIVSGIGSAVGVKFLGENGEIIRDLYYFYLLNDGVYMAHRGSFAVNLVHRREHVDVVLALTKKFCGDILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU00</accession>
    <name>A0A370PU00_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_333392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017059686" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="135" mass="14668" checksum="396F5B8BAA5A9354" modified="2018-11-07" version="1">MVQFKTIIALLPLFLSASLASPSARNNLESRESCEYTCGSTCYWASDVSAAQAKGYSLYQSGDTIDDYPHEYHDYEGFDFPVSGTYYEYPIMSDFDVYDGGSPGADRVIFNGDDQLAGVITHTGASGDDFVACSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU62</accession>
    <name>A0A370PU62_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rpr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_290556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU62"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="202" mass="22667" checksum="581D8D2F6911247B" modified="2018-11-07" version="1">MAKAKAKGKKDPAGGAHSHIRARIDYLYNTATFLQSIGKPSPQQPSASQQNDQINIAEDATKLQGTERIVPQIVKSDLALEEEPTKPKNTSVTERLPQLSRVYMSQMRGVSLKSQLRLPIDVKRSFCKRCDTFLIPGVTCTQDIRNASRGRKKPWADVLVVCCSTCGTEKRFPQTDKRSKKLFERRKEVPKEEHKDEVMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUE1</accession>
    <name>A0A370PUE1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_324618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="382" mass="41745" checksum="CBD9D24488ABD117" modified="2018-11-07" version="1">MAGDDFAVEAFTLLAIAIVTIAIRIVARWFTAGWKNFMLDDYLMPLAGVVYGLETGAAYCVSAWWKGLANNAMTDAERAALSPSSEEYHLRVGGSKTQVLGWSLYTTLLWLLKSCMAVFYSRLTAGLINMHIRIRIAYVLIAVTYIAVILSILVGCHPIQKNWQINPNPGNYCQPAVSHIDVYVTVVLNVATDVYLISIPTPILFKARLPWREKLELLILFSGGTFVMACGILRCVLIVTAGANGASQAGSWACRETFVAVIIGNAPMIYPMCRRLAMRAGWYMSTKGTKGSSQSYPLSEGAAHSGTDNSRNKRRKFKHPLSLPDTQWNTISDEQMMLPPGEWEVSHAARSNGDGNGTDGNSSNGVYDGGWKGGRETVVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV89</accession>
    <name>A0A370PV89_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="147" mass="15711" checksum="C55447629DBD3363" modified="2018-11-07" version="1">MGGARNISHGRGGAGNIFSGNNESRTTPKDLVTPTIKQDIFTTGRGGSGNMMHNDPEHPEIAREMQDVESPPLRVEEAPHFMGRGGAANAYIPSAEEEKRVREQEEEQLRRVRTQSKDRRKDAETASVAGEGGAGGGGGGEERNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVS0</accession>
    <name>A0A370PVS0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre protein translocase Sec Sec61-beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_273394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="11906" checksum="A6BEDDE8ACF3E799" modified="2018-11-07" version="1">MTSGAESGPDSKSAGAGTGASAVSSVNRPSSPTPPGGPRAAMRRRAAADHKESLRNARPSSTRAAGAGGSSGTMLKLYTDESPGLRVDPVVVLVLSLGFIFSVVGLHVIAKITRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVZ6</accession>
    <name>A0A370PVZ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_324075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVZ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="324" mass="35951" checksum="0646A5722401ED93" modified="2018-11-07" version="1">MSYSRSILITGGTAGLGYYCTIELARQFPDYQIIIASRSDSRDAVGSINKLLGQSNVSYLRLDLSDLSKVRSFVQQWETNKYPPIQYLLLNAGLQFPGPVEYTVDGYEKTFAINHIGHALLFSLLVPHLANTARIVVTSSGTHDPAQETGLPDAKYTSAEDLAHPTKSSAQNPGRQRYSTSKLANVLWVYALHRRLSESKDARLKSWTVVAFDPGLMPGTGLVREANPVLRFLWHVIFPRVIPLLRVMLGTPNIRLPQASGANLAWLASGKEALSSSGVYYEGRKQIRSSEESYDVSKQDDLWDWTVRNVASTADEAARFSLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW83</accession>
    <name>A0A370PW83_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_317403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="67206" checksum="70B8C820BE3881F5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM5</accession>
    <name>A0A370PWM5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="8353" checksum="A9F4F6372E131647" modified="2018-11-07" version="1">MSSSGKDFSYKGSGTNSQGNHWCSRDYGSGSRNSNSYHYSNSDGSYYYSNPNGSTYYNNGNGGSTYTPPSGNGGSTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWW6</accession>
    <name>A0A370PWW6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_208577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016886190" description="Multicopper oxidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="186"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44125" checksum="955196FF24812CAC" modified="2018-11-07" version="1">MAFPSPLFAFFMLLGLLDSVRAIGNWSCPDLITSSVPVKLALILTEQNISPDGFQRKGILVNGQFPGPILEVCQGVEVEVQVWNELPYPVTVHFHGIEQRETPWSDGVPGVSQKGIQPGLSFTYKWRATDSGSYFYHSHERGHLEDGLYGAIYIHPRNSVERPFAQITDDPSQLEAMHIAEQNTKPIILSDWRHLASEQVWEAEEATGLDAYCANALLINGKGSVTCLSQETIDEFTSEDLKPLLNGSHLTDIGCLPPTIPAAQGPYHHNFSAVPQSLFSGCNASHGATETLLVDPGLQYSSWDLINAGGLATLSFSIDEHPMYVYAVDGRYIVPKLVEAVKLVPGRRFSVLVKLDKPPRDYTVRSNIVGNQILNTTAIMSYDAAVRFQNDPSTPYIDITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX51</accession>
    <name>A0A370PX51_ASPPH</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_306054</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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    <sequence length="1605" mass="169306" checksum="DC39350437060E12" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
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                <person name="Mortensen U.H."/>
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                <person name="Andersen M.R."/>
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    </evidence>
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    </evidence>
    <sequence length="408" mass="43582" checksum="214A6D6B42D8FB58" modified="2018-11-07" version="1">MSTAGTLPPPPDGGFHAWAQVVSGHLVVAVTWGYAASFGVFQDHYEVTLPQTSSDISWIGGFQVFCLLFMSPLSGRATDAGQARLVVGIGAFLLLLGTFMTSLARVYWQLFLSQGLCIGIGQGLMWLPSVTLVSTYFVRRRVFAVTAAATGTSTGGIIFPAMIQFLSPRIGFPWAVRCMGLVVFVMLLIILALLRPRLPPRKSGPLIEWGAFTEPAYMLFTFGVFLLYWTLYFAFFYIQVYATDRLGLSARAGVNLVIVINALGIPIRAPCGYLADRYLGPLNCLIPWVSICGVLMFCWAGVHNVAGLYIFAVFYGLASAAAMGLFAGTVPSLTKDLDKIGTRVGMALAMISFGPLTGPSVAGALIAQSGDDSYLPAQLWAGAALMVGALALVGARIVITGPHLLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXE4</accession>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">M752DRAFT_306161</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="665" mass="74428" checksum="8697AE99A6AB4E97" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXI2</accession>
    <name>A0A370PXI2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_244938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="179"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="503"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="743"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="787" mass="84836" checksum="FBB26637F366490D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXT0</accession>
    <name>A0A370PXT0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAPS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_68272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="923" mass="100584" checksum="0618E590AC016026" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYM5</accession>
    <name>A0A370PYM5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_245564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
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    </dbReference>
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        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="17"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="59791" checksum="0E1272AB9AC413F5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYT5</accession>
    <name>A0A370PYT5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nuclear envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_208611</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:nuclear pore transmembrane ring"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72478" checksum="B9506DEDDCF3F3D7" modified="2018-11-07" version="1"> </sequence>
</entry>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">M752DRAFT_306478</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
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    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
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                <person name="Mortensen U.H."/>
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            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1388" mass="156781" checksum="6AF89D4D0DAD1150" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ52</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Theobald S."/>
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                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Tsang A."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370PZ52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
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    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="668"/>
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    </feature>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK47472.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="897" mass="99802" checksum="3478EE95D97D7294" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD1</accession>
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            <fullName evidence="4">DUF676 domain-containing protein</fullName>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
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    <dbReference type="AlphaFoldDB" id="A0A370PZD1"/>
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    <dbReference type="PANTHER" id="PTHR42044:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56119" checksum="5B7EC39B87763D77" modified="2018-11-07" version="1">MGILESIISSAADKFQGADERSVRRLLGTILERIKRSPDLINPHLLLETVISLTKYVLAAVFGPVGSVSSIREAVFKNEINATTLILVRDQAAELAKFVLDLVEASKCYYMTNGQNDLEDEHVLYAEFNELDFSVRRNQHAAICQIQRLTKSVIYILQDLFKPINFGDIHMSEETKLQSDLGSGLPVPHKTTPSAEPVSNRVVESNRSGKKTSPKGEVKVSERGEKWLFVNGIGGEIFWLQLACNKLRAMFSREINWVFNRGDGLLWDLIECAGQRNSYVQNPDTGSTTTSIDVDGVVGGQGNLIDSTASSKEAQEALHKELLKALREAHEKQYVNMIAHSQGCLILRRVLEDLITAATKNSTIQKKLQEQLCIFTFGNPSLHWKTQGKHPSVPSGTDGTNLSSHILRTEHFANRRDFVARLGVLSEDSEYGSDEIFINEREDWIGHLFGTQYSFNSDHYQNSHHQHSWLLGCRFGRSLDEARGKLKHLLPVSPSPLKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0A3</accession>
    <name>A0A370Q0A3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_6583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0A3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="106" mass="11723" checksum="7339E30E1478857F" modified="2018-11-07" version="1">MLKRQQQSMGKTSDHEADSCSMGIKHIIPQRSQVSPFKRSLANGLPSRSIRILLSMIPRRRLLRNAQPGRTIPSVLLVELASSCAPQCHHTPSVGLSRFQSIPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4P4</accession>
    <name>A0A370P4P4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_298859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4P4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK36780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="45438" checksum="EE5AFD572107BE63" modified="2018-11-07" version="1">MKSFQFARRRALQSLVAPRAFQSPATAQLWKRCFSATSAAASQLAPLDPSKLTVSKTTTPKELTAPKDLVFGKTFTDHMLSIEWTATEGWHSPQIVPYQNLSLDPSACVFHYAFECFEGMKAYKDESGQIRLFRPDKNMARLNKSSKRIALPSFDGEALTKLIGEFVKLDSRFIPSERGYSLYLRPTMIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGDKKLGANYAPCVLPQLEAASRGFQQNLWLFGEEEYITEVGTMNLFVALKNKETGQKELITAPLDGTILEGVTRDSVLGLARERLVPKGWNISERKLKMSEVAEAAEEGRMIEVFGAGTAAIVSPVRTISYRGKLVDCGLKETEEAGEIALQMKNWIEGIQYGDESHPWSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P545</accession>
    <name>A0A370P545_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_279970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P545"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="190" mass="20700" checksum="AE0327DA9A72C243" modified="2018-11-07" version="1">MPPKKRSAPSSGPAPKRARQSKLAKENDISASEENEIKEVFHLFSETVEEFADQKEGVIPRGDVRKALVALGLDPTDSEELHSIIEAVDPTDTGYVPYEPFLAVAAAKLRSRSDDAMAAEVDAAYRLFTRGSGGVITLNHLRRTARELKEEELGDELLKDMILEANGGAGVHAGVTLEQFHDVMTRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5J0</accession>
    <name>A0A370P5J0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_279965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5J0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="40505" checksum="7105C394A8A9EFA8" modified="2018-11-07" version="1">MEDGSEISRLAPELSDLEVALFLCLAAHQHCRIDTTDANIHDVAKELALICTNTFGLSYSILDCSSATSLDDFRAELLPPGVYRSSYARPSRSRLTTESAGMISSYHDLRDHKGRLKSAPIEHKQEVVNVVIAKNFNHVNDNIQREALELMHSKQLTTPAGVLEAPNNFLFLPLIVRDETHPINPHLNDYLFISHFHDTEDGYVYLEENNDWLSDGQLSASSVIHKSEAQMKKGHPYVDSTLLGQLQQLSTTVSMGADIARYQQDIVVFLRLSRAVAGGISTRSNLYFKSFSKLLAVLHGIDFLTPSIVALAARKVFRHRIIVAKPEEDRSLQYGSDLHAVSQVLEYANPDSILDGVLTLEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5W6</accession>
    <name>A0A370P5W6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_224569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5W6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36131" checksum="B47570AC1120A0C8" modified="2018-11-07" version="1">MASSLSKGPFSAIRSSNAPFSAFYSGPAIATPCQRRYLSQSSQRSAGLRGMPQNISMPAPAQPSMRTRGRGMPRTDLPQDIGLLPGTFIRPLWRDMPSIFQQPSERLHMEWLWIKSAFQNFIGVLAYCKWLNKGLALRLKERRQIAAEYHKKMYTAFAAGDIATLRKVCCTGLANQLSTRIAARPKGERVTWNLDSYIRSPGTYFTGVRVMSDRATQIPEIPNSGVRQVVLRITSRQSKGTTKASPNGAPADSTAVANNTKQQDCTEYLVIQQFRWAGEEDQWRVWGHATPTTVEDLESPFFARGMSLADRMEAMRETMTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P634</accession>
    <name>A0A370P634_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_270933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P634"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="605" mass="64322" checksum="8A0AEF5D41AA5CC1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6C9</accession>
    <name>A0A370P6C9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_270765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6C9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="285" mass="32252" checksum="FD627F4FD38717B2" modified="2018-11-07" version="1">MAGTALSVLGLIQPTVIDLLRKGMQNRDDINKLLRNESTMEIVIRGLKEMLDGLEGNGSSDGSDDFLRELFDEFKKSVRALHGEMQQIREAYPNDQSRLRFLGLSPQDHRRSRKLRKLQDHFTDVVEKTDLMRKCAELITRQGGGGGSGSRMHVDPVGVDTNSIADAPRVRSPGRQLQSLSTSQVNRQTRGHRHGRTYENPSRKDLSQTHQDMEKAIYRRQRQGKCRNCGWLGHWEYRCRERCGKCSYTLEGQIWRSHKVSGCEGNVVCFSCGGVGHMHGDCPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Z7</accession>
    <name>A0A370P6Z7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_298218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Z7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017017755" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="135" mass="14822" checksum="43711E91DBBA103B" modified="2018-11-07" version="1">MAGIILQLLALLYVAISLIVTSSLGSDAHSEDVHRAAIAAIASIYVTGVGYAFGWNSIQYLIHAEMLPSSVRTLGTSILMCIHYANRFALTKAVPTMTLADALQSKGRFWFFFVVAFLGFLWGMFLLPETSEMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P736</accession>
    <name>A0A370P736_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_88821</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P736"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23425">
        <property type="entry name" value="beta-trefoil_Ricin_AglA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000177">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000056">
        <property type="entry name" value="Alpha-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000077">
        <property type="entry name" value="Alpha-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016671651" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="417"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="537" mass="59201" checksum="4C32FB2E6A94F53E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P739</accession>
    <name>A0A370P739_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_298014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P739"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="6968" checksum="5A6D5A97DD505758" modified="2018-11-07" version="1">MELGDDNTVTYEEERFSEMEASIEESTKLQLRKSGSFFLATAIGLTALAVTTAHINMRRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7D3</accession>
    <name>A0A370P7D3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_321368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7D3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="131"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="732"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="876"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="857"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK38095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="111555" checksum="56BF655C2D2B4AA8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7G7</accession>
    <name>A0A370P7G7_ASPPH</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_81483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7G7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="554" mass="62951" checksum="310548FEA4867C19" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7P0</accession>
    <name>A0A370P7P0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_257589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7P0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF68">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016876916" evidence="6">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="40975" checksum="B40E90B0FF3797D6" modified="2018-11-07" version="1">MASKTLLLIPALATAALGSVLDLDIKVQNGYRTIEVDLGTPGGPFDLMYDTGSSTLWVLDSNCTDDCPNVSGYSRHDYNLTSTGVDLGVNDSIAYSGGTVSGFTATDILTVPDTNVSYRQSFAVITDSTWAALAADGFIGLASSTIAFKNTTTAVEQMMQDGLLDEPRFAIYAGSGVSTVTNPDPENNGVFTFGGSHEETYADGELQWMKMLSPFEIYKTNLLGIQGHNNSDGQALSSDVLNWYGQVIFDTGASSISIPNDQIEAMYALTPFSYADISSGYRPLCSDFNDTWSISFTMGFYGEGVTFNLTGDQLAVPGYQDDDHCFPPFNPWDSYNTIIGQHWLSNFYAVFDFGSFDPETYDIRVGLAPLKKEYLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7U1</accession>
    <name>A0A370P7U1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_257672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7U1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="480" mass="52993" checksum="13C5660FCAC09885" modified="2018-11-07" version="1">MEHKENSIDGFPTDPAMDWNGPGDPDNPRNFPRASRCMGIVSVTLLAFVSAFSGAIYAPAQNAVMESMNCSYEVAMLPLALYNLGLAFGPIVGAPLSETYGRKAVYLVTTPIFMVSMIGGTLCNTISGLILCRFLAAVFGSSNISNASATILDYTSDNERGTVLAIYYAVPTVAATLAPLVGGFIMIRIGEWRWTQWVPIIFAAAFYCLLIFTKETYKAVILRRRAMQLGLMGTHRGTTIGGSLRHLFIVLFQRPIHMLLTEPIVTCISLYNGFLFGLLYAFVISVPWVFEKYYGFDPQARALSYLGVTVGNIAACIPHALIDKYFFLPRLQSWKQVHDQSLRMPPEARLVSALGGGLLLPPSLLILSWTANFQVHWIVPIIFQGFSMFSCLLVYSGTNLFMLDTYGPLYGASASGAMMFSRYILSCAFPLFTLQMFDGLGVGWATTLLAALSLLMAPIPWIFWIYGPRIRKASRYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Y0</accession>
    <name>A0A370P7Y0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione synthetase ATP-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_307531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Y0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="146"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="376" mass="41095" checksum="C19C84C1F4F3E75D" modified="2018-11-07" version="1">MFASRAVRISAQAARAFGTKTPTVAVLHQAIDPPVINGVTKPRKPGGYQDSGADIAFTFQQKGVKIIKSDPAASVSSHKGWAFPDTEEGICSAIHQGATHLWANTILFNSHPLQTSSKLTPLVSEIYVVGQPPSLVENFDDKAYLNDKLRELGRYTLPSSWVVSPKDFSEVINKINSYPIVGKPVRGRGSHGVKVCHDKTQLQQHIQTLLHESPLVMLEEFLAGEEATITVMPPTRDRPQHWSMLPVTRFNHAEGIAPYNGVVAVTANSRAISPNELKDPAYKKVMRECESVAALIGATAPVRVDVRRFAEGSDFALFDINMKPNMTGPGRPGRQDQASLTAIAASAMGWNYSTLLQNILMGAQPLNVFRNYKSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8N2</accession>
    <name>A0A370P8N2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_338937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8N2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="715" mass="81345" checksum="BD94678B15F9D4C5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8X9</accession>
    <name>A0A370P8X9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_256960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8X9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29878" checksum="019599B0E7DB004D" modified="2018-11-07" version="1">MAHETAHYQEFPAHENDPLLGHRGPSSKPSPLSQLRRHLRTEVDPHRADLLLIFCYVITGLLDSSAVFIWGSFVSMQTGNTVYFGLGLAGLDETQRWLKSLISIGSFCIGSFFFAVLHRLFHTPRQRSALTLSFALQMICVAVAASIVTVQQTGKSDPLTWKIGVPLALVAFQSSGQAVSSRVLKCSSLTSVVLTSIYCDLFSSPGLASVSVLKAPDEWRRLGAVVGMLIGIVAGGWWARSEVGLPGALWTAVVFKGLICVAWMLWKTKDVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P939</accession>
    <name>A0A370P939_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_307394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P939"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="388" mass="42013" checksum="28CEF8FE1E825800" modified="2018-11-07" version="1">MSKPVSVIVIGGSHAGLAVSHKLLRQTPRAAITLINPSDEYYFNIAAPRFLVKPESLPPSKYLYSISDAFREYPEGSFTFVKGLVTKINYSAKSVEVALSASPSTTSTASFNFDYLVIASGSSTPATLGTAGVKLPFKATDFEDTRKAIQEAQTKLSAAKRILVGGAGPLGVEIAGELAEARGPKQVTLVSKTSVLLEGATETVQRTALSLLERKNVNVLRNTSVVDAAYEASTQTWKVKLSSGQTYIVDAYIATTGTVPNNDFIPTNCLDEQGWVKVDDQLRVVQDGASRNDTYAVGDITCLPYRLLSRVSLQGKTVASNIAAAIERRFPVMTYSAEAQKRMMVVPVGQSTGTGHIGRWTLFGCLVWWFKGKDFLTYEAPKFLRGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9B2</accession>
    <name>A0A370P9B2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_73819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9B2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016934832" evidence="7">
        <location>
            <begin position="25"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="223" mass="24055" checksum="DF0D662083DBED21" modified="2018-11-07" version="1">MGAALSTAGLVLLSFVLSSGGVQGWNRGFIIGLLVTSVVLLIGFVFVEKKVSNPIMPLSLWKLPHFPLLWLSAFAVYGSYQTTLYYAVLAAQRVSHLSAKQTAVCFPPMGGCGLILTMLLGYLIDIVSPRMLLFFGMSMAVVAPIPTSVGMHENMSFWTGLLPTSILGIAGISLSWVTVSTVMLSLVPVNVKSFYSGMINTAFQFWSCGRSRYSGSRNTRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Q8</accession>
    <name>A0A370P9Q8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_329494</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Q8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016663500" description="glucose oxidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK38923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="588" mass="63677" checksum="C66F63A339D5ACD4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA85</accession>
    <name>A0A370PA85_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_269220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="343" mass="39057" checksum="6B027E862D881294" modified="2018-11-07" version="1">MYTTRNVTDQNIIPSTLASRECKPSIGRRRRLRIRDERSGNARDHYLNQNVIKIRYGKMERQLPTRGVRVLDTQIAPERYGVKREYHDPSTPSADSTQVNEGFKFLAVPTETDDLEATCTKLKELAKTVEQGNSLALFTGLKLATYPSKSDPESVAMSQLTPEELWMYETWKEMKMIQDAESTIGDRSCGEEDRNGMKLPYFDWEQNVAPVPQGAQSLKRFTQRAAAMDVAFGHQGATPENASWLTSHMIFMLPLVKAVTKITNIKKNLKNNHQSRHTRGLTDMEAAEVETARKLVAIATKNRAREMEKIRRLTKSIEEDALIIRGRAEALERSRHTSTVPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW5</accession>
    <name>A0A370PAW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_238647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
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        <property type="entry name" value="LCCL_sf"/>
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        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
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        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
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        <property type="entry name" value="LCCL"/>
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        <location>
            <begin position="465"/>
            <end position="488"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
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    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="231"/>
            <end position="284"/>
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50820"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39341.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="656" mass="72906" checksum="DA41DE8AD6E83E08" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBJ0</accession>
    <name>A0A370PBJ0_ASPPH</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_50183</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
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    </comment>
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        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2058" mass="225146" checksum="3C605F0990449985" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBN7</accession>
    <name>A0A370PBN7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_220043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="527" mass="57264" checksum="D0E1724F1C5A4425" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBZ3</accession>
    <name>A0A370PBZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF179">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="506" mass="55675" checksum="90A8176A18DB566D" modified="2018-11-07" version="1">MSYQQPYGQGPPQGYNQYPPAGQYPPPQGQYGQHQQYPQYPPQGPGPYQQGPGSHQPPQQHGSYPPPMAGHHPQQTQAPYPPQQQHPPQGASPYPPPMSGQHPQQPGPYSSYPPSQQGMGYPHQGPPSQQGYPQGHPAQQGYPNPPQQQYQSFPPGPPGQQPPPMMAPPGAGGPYPSYNPQQGPMPSRPSPGYDPTFLAPGTASNEAEVLRKAMKGFGTDEKALIRVLTSTTDPNRMALIRHTYERMHNRSLTKDLKSETSGSFETILVSLATGPLESDITYLHDAMSGLGTNETGLNDVLLGRSNADLAAIQRAYRDKYHKSLLDDIKGELSGKTERFFEMLLNARRPERGTPFDPRGVETDVRELHRVTAGKVGTDEVAVFGIFMNSSDERLNVLAGEFERMYHVSLEKVIRGEFSGHLEDALVTMLRVARDPVSFHGATLKGCFFGSNGVNEKRLIYWTVRLHWNPEYFARVKGTMGGNLRALVKNYVSGGDFEDALMAVCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCQ3</accession>
    <name>A0A370PCQ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CmcJ-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30712" checksum="A90D1C263C74ECEA" modified="2018-11-07" version="1">MAFAGSSVGRTKGYLDFLGKEQDYHTMVLYRSYDGLASSNFSSFPQEVSFEDIRGKETEFSIQEQGFCLYSLSTKMSYIDFDDDFEIRATLYPEVKRILQRLTGASIVKINFHWVRGKHPSGSGPVGYAHIDTTGPSGAYMFETYRANSGVDIAPSRKYEFYTFWVPLLPVQDYPLALCDQRTVKPEHLLPVTHYDSSATSQNCFLQHDPEQRWYFINNKQPSEAWIFYQGGNRVENKPGVPHGSFRSWDMGFDRRQSIEIKTMVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCQ6</accession>
    <name>A0A370PCQ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Camp-dependent protein kinase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_304421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="251"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="45519" checksum="9910C00B24FCF6B8" modified="2018-11-07" version="1">MFRDDYSRRRIKFMPGRIEAEHCSHVSGSPTLAPEGHPEVSVPLSFQDPFTLCPRASTLPGSGDDMPPSTDTSHYPLPRRNSVSAESFVPGQQSLPSTSFDMTEEQAHRLVRAVKEVFLFSALDKEQYAQLLSAFVGKAVPIKGTNVITQGDIGDNFYIVEKGSFDIYITLASTPQPTTPSIGTKHGSAHPGDFFGELALLYNAPRAATIISTEPDCHLWAIDGVSFRRIMAESAFARRRVHTSFLERVPLLAGLSGRQRSRIAEALQTRRYCAGDTIILQGDLGSDFFLLVSGEARAYKVGFVGSVKTYTSGGWFGERAFRKNAPRAASIMAVTDVVVAVLDRDAFARLLGPVEEIMGNTQYEGVVDEEEVLLSDGQSSENIPPPFHDESKKMTGSQKSCPSSSDASKWLTLARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCS5</accession>
    <name>A0A370PCS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="15">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TAH18</name>
        <name evidence="19" type="ORF">M752DRAFT_285381</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="function">
        <text evidence="13">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <text evidence="15">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="15"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
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        <property type="entry name" value="Flavodoxin_1"/>
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    </dbReference>
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    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
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        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
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        <location>
            <begin position="202"/>
            <end position="456"/>
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        <location>
            <begin position="168"/>
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        <location>
            <begin position="187"/>
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        <location>
            <begin position="19"/>
            <end position="24"/>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
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        <location>
            <begin position="66"/>
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        <ligand>
            <name>FMN</name>
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        <location>
            <begin position="104"/>
            <end position="113"/>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="357"/>
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            <name>FAD</name>
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    <feature type="binding site" evidence="15">
        <location>
            <begin position="387"/>
            <end position="390"/>
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        <ligand>
            <name>FAD</name>
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        <location>
            <begin position="426"/>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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        <location>
            <position position="468"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    <feature type="binding site" evidence="15">
        <location>
            <begin position="536"/>
            <end position="537"/>
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        <location>
            <begin position="542"/>
            <end position="546"/>
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        <ligand>
            <name>NADP(+)</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK39998.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="889" mass="98485" checksum="74D24A29B4AD9892" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD44</accession>
    <name>A0A370PD44_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_278014</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
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        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribosomal_uL23_A"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="Ribosomal_uL23_N"/>
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    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
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    </feature>
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        <location>
            <begin position="39"/>
            <end position="53"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03939"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40123.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="16998" checksum="554DCEF0DF4EC4A9" modified="2018-11-07" version="1">MAPKVENKQGKTKPSDKAGAAAKAVIKGAGAHKARKVRTSTTFHRPKTLQLSRSPKYPRKSIPHVPRLDAHKVILYPLNTESAMKKIEENNTLVFIVDVKSNKRQIKLALKKLYDVDTVKVNTLVRPDGLKKAFARLTPDVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDD6</accession>
    <name>A0A370PDD6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_295384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="440" mass="48348" checksum="FBB41801413DE3E8" modified="2018-11-07" version="1">MSQLSSNPIPFSEPPYLCGLPSPYYSPGHRRFQKACREFFWEHLHSHAAEYEKAGQVPEHVFHTFCKHNMLLPNIGAPLPVEWLKRLGIADILGVKVEDWDYMYTGIYFDEMARSGMAGPGSSLNAGFNFAIPPVLKYGSRELQERFLPDLLTGRKRCCIAITEPEAGSDVANITTTATKTPDGKYYLVNGAKKWITNGIWSDFATMAVRTGGPGASGLSLLLVPLKGHPGVTMRPLKVTGPITSGTTYIELDDVKVPVENLVGREGDGMRMIMTNFNHERLSIAVGVTRQARVALSTAFQYCLKREAFGKTLMDQPVVRNRLARAGAELETLGAFVEQLLYQLCHLSKEEGDRRLGGMTALAKAKAGMVLNECAQCAVLLFGGSGLTQSGQGELVESILREVPAARIPGGSEDVLLDLAVRQLVKVYQTRQRKLNQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDK4</accession>
    <name>A0A370PDK4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826803" evidence="3">
        <location>
            <begin position="25"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="492"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="637" mass="69474" checksum="65E211DFF59F7F42" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEE9</accession>
    <name>A0A370PEE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_34210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="14212" checksum="CB51B6B32F3B23EA" modified="2018-11-07" version="1">MAATQTASLLLFIFFFPSSLCPLSHLWPIPTKQKCAHRPCTLDKRSPNAEQKRFAVRQLNADRGKLTKPKEKKKLFVFFCLSFLTAFMGGVEGIFSGIVSFQLIQTVVSFSEAVSGWESPSMNECTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF7</accession>
    <name>A0A370PEF7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="14719" checksum="B6EDB227A26F4E3F" modified="2018-11-07" version="1">MSKATRIPIRAQKAPLPPPFLSQGIIVGDMVFCSGQVGVNPATGKMVEGSIQERTKQILNNLGAVLEAGGSSLQDAVKMNIFLADMNDFAAVNEIYAAFFEDPLPARTCVAVKTLPMGTDVEIECVGVVRGVPSRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEM6</accession>
    <name>A0A370PEM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_320040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="796" mass="90170" checksum="F9338496745A281E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEX3</accession>
    <name>A0A370PEX3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_284931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="474"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="646" mass="72787" checksum="040BE5A30324E42F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEY6</accession>
    <name>A0A370PEY6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_303469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEY6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="507"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="679" mass="77189" checksum="F0F15298E846671C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEZ7</accession>
    <name>A0A370PEZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_237502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="285" mass="31334" checksum="EB1240ECC16E361C" modified="2018-11-07" version="1">MGLAAPRKKIKISHDPNNTNWSRSTSGFGHKILSSQGWTPGSFLGARNAAHAEMFTAASASHIKVVLKDDTLGLGARPKRDPLNEPTGLDAFKGLLGRLNGKSDADLQVEQQKRDNVKLARYAATKWQAVTFISGGLLAQEKTTPIVTEEPQGIHKDKQEDKLSATVPGPDSDGVEGSDNIGGQSDQSIKKKKSKSKNHREKKDRKRKHTEEPESTDSGNTNKRSTEKKSKATRDDEESSSTTSKGLSRERRPMGRHVFRGRHIAQKKAALMDEKSLNEIFMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFS5</accession>
    <name>A0A370PFS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65186" checksum="DCC845CCE233FFE2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFX8</accession>
    <name>A0A370PFX8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_319847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFX8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016571598" evidence="3">
        <location>
            <begin position="26"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="45"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="53534" checksum="AEA880C23140CA5E" modified="2018-11-07" version="1">MAVHRGIIEYFLVILLGACAVSVDGSSQVNLGYACYRGVRLPAGVDKYLGMRYAALLLGHSTSSIQNAFKFGLTCIGVGEKISLLVGEDCLFINIFTSSHATTLSRLPVWVHIQGGGYASNANANFNRTNVIQHSGYDLVFVNFNYRVGVLGFLASEEIRRDGDLNIRLLDQRKILAWVKQYISQFGGDPDYVIAHSNSAGAGSVTYYMTAYSSRAEGLFTGAVLESPFWPTLRTVAEMEFQYIQFIQRVGCSDVLSALACFQSADLAAIQKSNVVDLFPDAALSRLFDQGKTVKIPMLVGDDINEGSTFAYNTSDAFDMSRFLNTNYPGLLSASLAAIGDAYPRMRSVADHAAYFPSASAAYGDAAFTCPGNHIAVSMADHLPSGRVWSYQYNVRAPELVDEGLGVLHIFELSAIFGVGFAGNSEITSYNGINVNAVATVMDYWISFVKALDPNPRRRSQAPRWEAWKPGLGQQLKIQTNTTTIEPIPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGC0</accession>
    <name>A0A370PGC0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_253406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="117"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="675" mass="74714" checksum="86B127E59227B173" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGF4</accession>
    <name>A0A370PGF4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gibberellin 20-oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_253490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="339" mass="38228" checksum="AEBC059A0EB43B83" modified="2018-11-07" version="1">MGSLQDGPSLSTTDLPIAPLRTIKYGALQNGDSKEIGRLLEACIHEGFFYLDMTDGEEIPAVLQKVDEMYDFMREWFGQPDEVKQEVLSSNYTDGYKPTGIFAGVRENTRDAYETLKVSHMGIKRGASNPPPYLKVRKGMFESYLEACNQIALRLLICLSPQLGLDKSEALETFHQDKENSNSTLVLLKYPYQEPDLESHQIGHNKHTDIGSITVLFTDQWGLQVLSAADQGQKEEQWKYVEPRRGCAVINVGDSLRFLSQKKLRSCLHRVVPAKGQTVDRYTIAYFLRPSNSATFVDSNGELVTATNWHDRKYEVFKASHADQRKDTILTGGLEPITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGF5</accession>
    <name>A0A370PGF5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_294937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK41285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="121" mass="13017" checksum="7A19B02B027585F2" modified="2018-11-07" version="1">MSAIGTLVFCTDCGSLLDGSIGDPTKILVCDVCGARNKDTVPQTIVSESKPSAFPSALRAKRSAVQTLTASDRRTEALTQHTCIKCGRKEMYYTTVQLRSADEGSTVFYTCVCGHKESTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGR1</accession>
    <name>A0A370PGR1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_301777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGR1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="34983" checksum="AC4C050DE91F035A" modified="2018-11-07" version="1">MSSSSPWLSGTHSGHVSVDGIQIFLSASGPARQTINNTLQPAVIIEAGLGSSHSEWVVVQRLIAERARVYTYDRAGYGLSDMSPREPTAQNRVYELSRLLEVAGIEPPYVLVGQSYGGVLIREFLRVHTKSKVAGMVIVDSWREPNPLPRGWFSLMGGVELDVVLGLDLNHAFSAEEYQKVKEDEKRNEAMFGDEEEFVARSMEMVNDGLPVGSQAMGDGRLSVVFGNRSMDFRKVLEFGVANGYGTEEVRESLAKRLETMERVDEESQRDHLGLSSQSRFVYAQGKAMTHNVHYVAPELIRDEVFWVLGLTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH65</accession>
    <name>A0A370PH65_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_294897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18141" checksum="A90BCB3FE40C6A9F" modified="2018-11-07" version="1">MLFPIPKTTATPMEGEVKIPLLFFVQRIQRLIYEVPSDEEAMNLVDDNYSSDALFEWNSERLDLDGFKKFVQEWRTRYTFLDFEFHEAVATPDVNDEEGRGGTIGFALKGRVVSKDDGKMYGGKVHAIFKVEWIGDRRVITRNAQVLQGPYVVEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI57</accession>
    <name>A0A370PI57_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_276586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="53422" checksum="7B83BEF471A295B4" modified="2018-11-07" version="1">MDDFLQRFGQEQADGSYAFSNVRSGLIVGLLCIGTMIGALVAAPIADRMGRKLSICLWSVIHIVGIIIQIATDSNWVQVAMGRWVAGLGVGALSSIVPMYQSESAPRQVRGAMVSAFQLFVAFGIFISYIINFGTERIQSTASWRITMGIGFAWPLILAVGSLFLPESPRFAYRQGRIDEAREVMCKLYGVSPNHRVIAQEMKDMKDKLDEEKAAGQAAWHELFTGPRMLYRTLLGIALQSLQQLTGANFIFYYGNSIFTSTGLSNSYVTQIILGAVNFGMTLPGLYVVEHFGRRNSLMVGAAWMFICFMIWASVGHFALDLADPQATPAAGKAMIIFTCFFIVGFATTWGPIVWAICGEMYPARYRALCIGIATAANWTWNFLISFFTPFISSSIDFAYGYVFAGCCFAAIFVVFFFVNETQGRTLEEVDTMYVLHVKPWQSASWVPPEGIVQDMHRPPSSSKQEGQAEMAEHTEPTELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI75</accession>
    <name>A0A370PI75_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_294448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI75"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016860750" evidence="3">
        <location>
            <begin position="18"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="590" mass="64123" checksum="F7E17A4B07A9C540" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIC4</accession>
    <name>A0A370PIC4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_284059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="349"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="635" mass="72649" checksum="0EF87678BAB3EE91" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIH1</accession>
    <name>A0A370PIH1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000074">
        <property type="entry name" value="DNA mismatch repair protein (Pms1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="809"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116328" checksum="2E9C1CA267E3AEED" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJA6</accession>
    <name>A0A370PJA6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_251369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="37166" checksum="43A804C784055483" modified="2018-11-07" version="1">MHHRLTFQTTYPWTKAPLIAQAPMLNIAGPELATAVSAAGGIGFIAGGNDVSNLESKFQKAEQLAKEYKAAGGSLDQNSLQLYEGPNLPVGVGFLSWGADIKVALPLIVRYRPCAVWLFAPSNSAANQVPWVEGIRAQTGGSVAIWVQVGSGSDGGGHGLQHSASIVSLVPEVIDQLSAETSVIPNGPIKPKIVAAGGLVDGRGVAAALTLGAEGVVMGTRFLASLEVSIPKGYQQAILDASDGGVHTIRSAVYDRVRGFLRWPPKYSPRGIVNETHRDFVTGKVTEQENYDLYQDALKKGNPGYGPNGRLATFAGTAVGLVREILPAGEIVRRSRKETEAILKIDRLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJL5</accession>
    <name>A0A370PJL5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_251491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJL5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="373" mass="41186" checksum="B1FA4F0159C293D9" modified="2018-11-07" version="1">MDSDTFPEPPSQAINWSSLGSQSIEFPTSHVECTYCPTTGSWGSPTVINNPNLQINGFAVGVNYGGPYYESLTARRTRDNRILLFRPLDHARHLADATLAVGMTAIPEYLFLTCVRKAVAINTSYVPPPQTDAVLYIRPLLFGPSFPRIRDSPPQYTFCVFARPGVVYPRTAAQNAIVLSDIAAHNVSTTMEGQKCSRNGIWDDGWKNGLEVTAQPDDQQAQRDVYTMKLRLETSRHGTFINGFTTSAFLGVQEEHGKYTLMVPRHPSRSIISDTCVAIAIRLGWKVKVGPIPVDDIDTLSEVIATSTWHLLLPIRLIFCPSAKQTVVYQAGSQHAGPACQLLRNAMAKIMGGDVSDIWQWCVPVTQQDRHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJS1</accession>
    <name>A0A370PJS1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_319248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJS1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="264" mass="30486" checksum="E4FF31B5E7764905" modified="2018-11-07" version="1">MSWTAFAPWQTQDQTEDEKPTHSQSYNQENAPCRSMRNSSPSYYNESNKILLAFYFCGRILHNTASAVLPSLSFFGRKSEQQRDEPLQLQHDEQIVEQCITDKNDYVLVHNNELSKGREELTESLNSALSHDSQLLKELDQCDFVYDVMAGPPGKNQLRRCMMLSFHADTNIMSKEAYLKLGTSIEPYLGAPIPVLGLQDRKPVGTAEVQWSFCGRSKPYRTTFYVVEEVEYDLLIGRPSMRQHELYRVDPAIAERLRDSYRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJX1</accession>
    <name>A0A370PJX1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_293593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="29615" checksum="5598DA5082B97175" modified="2018-11-07" version="1">MTQSDPQTTSIPNPFRTRILSGQITPLLTAKYLTTNELPLLCKTTSIHAVFIDMEHSALDMRTVSQLILACHCAGISPVVRSPSKSHFHISRILDAGASAVVIPHVESVEEVKEIVQHGKYAPLGKRGCTNNQPAFGFRHVSTKVQNKVLNEQTMLIPMIETPGAVEIVEEIVAVEGVDGILVGSNDLCSDLGIPGGYDTAEYQDAVRRVIKACVDAGKPVGIGGIGGRLDILEMWFRLGATWSLGGQDGAMLQAGMKGLSQKYEEINARLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKF2</accession>
    <name>A0A370PKF2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotriazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_314975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
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            <end position="510"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42679.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="58562" checksum="7B714BDBB424467D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="100" mass="10971" checksum="914779F3DD579046" modified="2018-11-07" version="1">MTLTSLVSFHPSSTWPYHQSAGIERFLSFLSKFLPISSATSSAIPSPPRSVSGSVMADCHDPDGWFPFFFLVFFLAFYSIMHKAASIGAAGNCQRSDYPL</sequence>
</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">ATCC 13157</strain>
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        </subcellularLocation>
    </comment>
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        <text evidence="4">Belongs to the phosphatase 2A regulatory subunit A family.</text>
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    <dbReference type="SMR" id="A0A370PL27"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
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    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
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    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
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        </location>
    </feature>
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            <end position="355"/>
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    </feature>
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    </feature>
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    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
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            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42896.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="616" mass="69140" checksum="FCC3360D19EEE200" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL50</accession>
    <name>A0A370PL50_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL50"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810967" evidence="2">
        <location>
            <begin position="20"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="763" mass="78338" checksum="DF0F75CE0D79D718" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLI2</accession>
    <name>A0A370PLI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_315148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="236"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="535"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="919"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1465" mass="161133" checksum="D9CAD09C453B509C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLK0</accession>
    <name>A0A370PLK0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_251176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
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    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="253"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="618"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="847" mass="94302" checksum="57188699BF1B21CC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ima1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="194"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="580"/>
        </location>
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        </location>
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            <end position="643"/>
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            <end position="742"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="RDK43113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="859" mass="95831" checksum="4837C4F58684EA4C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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            <end position="82"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Kogle M.E."/>
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                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
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            <end position="52"/>
        </location>
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        <location>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="EMBL" id="RDK43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51609" checksum="6AB48709A27B9D6C" modified="2018-11-07" version="1">MPAGSCQVYGSVSGEDINSYPKYTGSPLLLFLADLWLFLRNIFYLPCIFLPLTPWSCGSLDELYPSLANIFDICLHCVLFVLQLIFLASLPLFIWLPFGVYVLYILTALALNTLICYALNRGIPADGLRSTEDDFSRRWNRHEDEYWIFLNGICVGRNWLQNNVDRISRTFHRPVVGVHNKTAGVIFDIIQCLIQRSLLYATNDVRDCYVLVRRALYRPEIKKVVLILHSQGGIEGGMILDWLLDEVPQDLIRQLEIYTFGCLANHFNNPYRDIASCNAAMRYVRTGEITGNVRNRTILHIEHYANQRDFACRFGVLNFDHSKPRDRRENRFMGKVLVSPASGHQFNQHYLDTMFPLDPTNRFTREPREGDFMDTDVIVSRHDRPEEDRPVTVLDAAGLLDAGTGEVDGTSLNSVRSGSTQNMKFGLNMRLKMHQMSRLWLYRNGGRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMJ9</accession>
    <name>A0A370PMJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_335214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="259" mass="30227" checksum="1BEFEFE626817DBA" modified="2018-11-07" version="1">MTMNTGNCLDLKLDNIMLSFEDPMVLAEFMETQLEKPMAFKLDSTGRPVYQSRNDFGPLKSLRSIPQLVDFGLATKLEENDDWGVWPIQPDHYRAPEVILGIGWQMPADIWNLGVLLWDLIEGKELFQHIHDKQGRYDAKLHMAEMVALLGPPPPEVMQRYQYMREYPWPEPVRREDDRLCETAEEYFDGPFFDTNGRFLYEDLIPNRTLGDAVSFLEGEERENFLDLVSKMLIWHPNRRKTAGELAEHPFLQPKQSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMK2</accession>
    <name>A0A370PMK2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_275629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000023">
        <property type="entry name" value="Threonyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="86"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="526" mass="59103" checksum="C896141072306301" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMQ6</accession>
    <name>A0A370PMQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="43686" checksum="41351DB430FB1B65" modified="2018-11-07" version="1">MSGFKGVMKEGWHPKGKDGKKESWRNDFKGINQVAGWMGKGKDNTNDREEHVAVPLSSLKDPASFGPPPKHIKYHGAAALPNETTPDRRGLGAPLPQEQIDHQNAQLQQQQQQMQLQEEAAQKPAPPPLPYRANRTGLDTSNLPPPPVRRMGSPADSIPPPSSRPKPNLPPRLPSRNNSTPSPHPPTPPPAYSPHSQTPSHAEEYINQGATSRLAQAGVSVPALGIGNNAGQWGRDSSSPSTASPAVAGAVGQAPVNELQTRFSQLRTSSSNSPAPPPPPARTYTNGSTAQSVSTPEPRSGSSTVSDFRERHNDKIQAGKQKLNGLNEKYGISQRVNKFFDDQKTPSAQAPPVPPHPNANSSTSSLDTDTLSKRKAPPPPPPPKKAGMRSTPVAGSAPTPPPLPLNTKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNK5</accession>
    <name>A0A370PNK5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_231978</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNK5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 19 20" id="KW-0349">Heme</keyword>
    <keyword evidence="15 19 20" id="KW-0408">Iron</keyword>
    <keyword evidence="10 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK43768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="52054" checksum="552E61F7858659A3" modified="2018-11-07" version="1">MPSPIPKPPGVFLLGNVKDVDAANPWNSFNKLAAKYRPICKVTILGVDIVLITGAALLEEICDETRFQKCVAGPIIEIREAVHSSLFTAKINDKEMNQWGVAHRIMAPLLTPGAVDQVFADMREVSTDLIKKWTAGPRQRVNVTNDLDRLNHAANMLCFFDQRLHCLEGPEPSLIKAMENATTEAVRRSSRLKLVNWLFYQRKFNAYNKTLRDYSASCMDYRRAHPSAKKDMLYALMEGKDPETGEGLNDEQIVDEIINVFIGSATAPNLVAFGLYYLMKNPHVIKRAREEIDAVVGGPGAKIEHEHLSRLPYCLAIAQETMRLAAPAPGFNREAIPDQEGPVLLAGGEYEVPRKQALIAVLYGVNRDPAVFEDPDAFKPERMMGEAYERLPSAVKKGFGTGKRVCIGKKYAWEWSYFTLVSILKDVEFELADKDYVTDGAGNNYNGAFTVKPLDFFAITGPRPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNQ3</accession>
    <name>A0A370PNQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="57"/>
            <end position="79"/>
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        </location>
    </feature>
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            <begin position="132"/>
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        </location>
    </feature>
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            <end position="196"/>
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            <begin position="45"/>
            <end position="270"/>
        </location>
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        </location>
    </feature>
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            <begin position="335"/>
            <end position="367"/>
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        </location>
    </feature>
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            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="42308" checksum="A64CC8B71F1E7232" modified="2018-11-07" version="1">MPSLSSSSELLPPLETITPYDTIVAFVFFFVTLIIVAVKLGTALYSKTVLLSTDAPLWIALIVAFIQSLLTQFAVDHGLGKHSSSLSTADFSKYNKLTYAAQLLLIPVLSLSKVSTCRLIHRLTPGQRIRRANMITMIAVGLWTVFALFATALQCRPHWEYLPSHCAGKGAVNYPIILINIVTDLALVVIPLIMIWSVQMTLQKRLQIIASFSSRLVLVAVSITELVYLPIYLQSSDPTWTIVDVDICNELTMYLSIIAACMPSVYRILSNLRSGLNGVHLSEIELSTTQGATGSRTESGNQGGSSSRAKRRSAFFPGFRATELFSRHDTTQSGLCTIQDDATRRNRDDTESTESTRGLTEDQPPVDGVRKTVDIYIEVNDIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNR0</accession>
    <name>A0A370PNR0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="54" mass="5688" checksum="93EF5DFE911AB817" modified="2018-11-07" version="1">MFYGSRVTIPCVTVIIVVVFGVIAQHKPNPSPADLNTRSPTEVSERAVSSGAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP44</accession>
    <name>A0A370PP44_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_275222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="486"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="783"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="882" mass="97774" checksum="EAA4C871F8DACA00" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP90</accession>
    <name>A0A370PP90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_292163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="26962" checksum="5478CFBF1DA39823" modified="2018-11-07" version="1">MTSEKVRPLPHLNPGEVSLLDLATDDPRDTVTLSDKEALILQLYRQIQEQRLEKALLEQDTDLLSGDNAEEQLAIAERELLEARATYTVRRKAVGTVLMTDPILKAVHLKASTPAEQALLRLINRRDMLSLAHENLNTAHSATLRRLSSLEVENSQIHQQNQELVRELLALTVDDESWRENLEDAELKAQLDQLDADRRKSKAKWETMKNIASGMVVGSGVNWAEDERLTALVLDESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPW4</accession>
    <name>A0A370PPW4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017017765" evidence="4">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="6">
        <location>
            <begin position="231"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39248" checksum="2634D5E9D2415F3F" modified="2018-11-07" version="1">MKLLVSFFIATIAIVLTCNTSTFTRYFTSTTNTNTNTTNTTITPNNTHTTNLTNMSFPRAIRQAFLAIEQAEGAGARVRRSIGTRNLRNFSPFLMLDHFTIGKGAGFPDHPHRGQETITYLLSGGVDHEDFAGNRGTIGPGDLQFMTAGRGIMHAEMPHENPDGSPNVGMQLWVDLPKELKMCEPRYRDLRASEIPIATADDGRVTVKVISGQSHGVDSVRDLAYTPVWLLDVTVKPGGRVKQVLPVGWNAFAYTLAGKTIFGSGGETKTITEFHNVVFEQKGDFVEASVPENADEEGRFLLVAGQPLDQKVVQYGPFVVTSEQEVYQAMVDFQTASNGFEKSRNWESEIGKRMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPY3</accession>
    <name>A0A370PPY3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000425">
        <property type="entry name" value="Cytoplasmic dynein 1 intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="679" mass="74696" checksum="37F01AE4A2D00459" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQU3</accession>
    <name>A0A370PQU3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein SERAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_313371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="68199" checksum="1D327AF4834B2B17" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQZ8</accession>
    <name>A0A370PQZ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_231664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="33573" checksum="A40B7DE0A9A0E50A" modified="2018-11-07" version="1">MSATVTETTTNPVPVVVAADNNTTSKTHIEDAANDKDFQSVARGNRAGTLKLRGIPTFSDPAAKRQWMKEHMAAAFRFFGKKGYGEGVSGHISMRDPILKDHFWMNPFAKHFSTIKASDLVLVDAEGYVTEGGAQLPINEAGFMIHSEIHKARPDVIAAAHTHSIYGKTWSAFGKPIEMLTQDACNLYGKVGVYEDHGGIALAQEEGEQIARALGKDNIACILQNHGLLTVGRTVDEAAFLYFSLDNACHTQLLAEAAAANGVPKRIISNEVAKYTADVAQNHHNFYTEFQPEYELIVEETNGRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB2</accession>
    <name>A0A370PRB2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="36992" checksum="8BD50F8F5465AFE2" modified="2018-11-07" version="1">MASLLRLLRTQYNPPVDPSGVSFAGKTVILTGATSGLGFEAAVKLLNLGVESLIIGSRNLQRGQAAKTELEKLTNRQGVIQVWQLEMNSFQSVKSFANRVNEELRQLDIALLNAGIWNRDFGVSPEGWEETLQVNTLSTSLLALLLLPKLRSSSSLSDPAHLTVVSSQQFVRVKAKSLRTVQPLLKHLNSPQSFKGPRQYGISKLLLEYVLKTVAGLVRNENGTVPVIINTVSPGFCVSSLGRQYSRFYERWATWLAYKLFARTAEQGSRSLVSATYQGVESHGKCWRSDGYLDESVALTTGAEGKQFQARAWTEIMNELEEQSEGLKESIRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB4</accession>
    <name>A0A370PRB4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_333634</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="62839" checksum="B907DCC0E7C1764D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRE3</accession>
    <name>A0A370PRE3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_274081</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000037">
        <property type="entry name" value="Probable exopolygalacturonase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF11">
        <property type="entry name" value="EXOPOLYGALACTURONASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620940" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="440" mass="47866" checksum="CD1EDC63EF3236DE" modified="2018-11-07" version="1">MSVFKASFLFLLSSSLVHGVPHSSRASRSQQCVVPSKYQASNGTADDSAAVSQAFARCATDSVIIFEEGVNYNIFQPITATNLSNVEIRMHGNLHLPQNITAVQNIVSDGTSTWFTLEGPKVDWIGPEDVNNGWIDSYGQPWWDANPAGSSGIDNRPHLMSFKSSQATMKYFRSRKPIAWNVKLHGQDITVSHAIIDATSTGSFPFNTDGFDVEGTNIQITDSIMYNGDDAIAVGADSHDILFTRNTIGYRTHGMSIGSLGKDPTDFANISNIRFDDVTVVDGLYAARFKSWSGGTGLVKNVTWNNIRVFNVTFPIFVTQSYSDQGASRSGTVNASSAVMMEDFTWSDFAGSINTYQPGDGSCVSDPCWYNVGLPNLKHTEALIIECHTAQSCKNFVTDNIQLYPQVLEPASVICMNATAALNPDLGFTCENGTYSPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT08</accession>
    <name>A0A370PT08_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_117897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT08"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="905" mass="102438" checksum="A1C83B8340C6C6AA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTU5</accession>
    <name>A0A370PTU5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_324487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="26922" checksum="00EB95A3A145A140" modified="2018-11-07" version="1">MASYLITGASRGIGLAMARTLASKPANEVSVIFAAARTQTDDLKRLVAQSSGRIHPVSMDVESKNSIQAAVATVEHALSGKGLDVLINNAGIMPSTRGGIENMDNLDTVFHTNVSSAHMVTSAFLPLLKNGNQKKVINISTTLGSITMAPRFALFPVPAYKVSKAALNMLTVQYAQSFADQGFTFLAISPGWVKTDLGGDGADITAEQSVQGLLDIIVPATHADNGKFFNIRVPGWEKAEGLNQYDGAEVPWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTV1</accession>
    <name>A0A370PTV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="37792" checksum="073673A4C5792BB3" modified="2018-11-07" version="1">MPSVFLIGPGLIGGEVLDLLLRDKKYEITTLVRREAARPAFHELGVKTVMGSLADKGVISKQTATSDIVIHTATADDLPSVQAVLEGVRQRTQLGQETIYIHTSGASLIGDGAKGSYKSDMIFDDETPSSIDSLPDHAPHREIDLAIVNARKELSSHAKFAIMIPPVIYGVGTREKRLSIQLPTLVRYSIKHGYPGMIGDGLSVWNQVHVKDLARGYLTLLQWLERASSKDIFPNPYFFCENGQELSWGECAAQIGRILKEAGKVADSTPKTIPTEKYNDLFGDFSGLVVGSNARNRANRLRKLGWEPREKNTFASLEEDEIPLILQEKGEFNGYAAPVASGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW6</accession>
    <name>A0A370PUW6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sulfate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_281352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="735"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK45979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115790" checksum="01124C8F99AB0184" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV03</accession>
    <name>A0A370PV03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_281368</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="11"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="16">
        <location>
            <begin position="556"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1364" mass="152250" checksum="DD07CCBD6CF63142" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV45</accession>
    <name>A0A370PV45_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_228730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="442"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="58689" checksum="A9C9EAC3485ACC8A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVA6</accession>
    <name>A0A370PVA6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_245913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
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    <sequence length="1283" mass="140195" checksum="8860E6ADC55410B4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVN9</accession>
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            <fullName evidence="15">PHD finger and BAH domain protein</fullName>
        </recommendedName>
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        <name evidence="13" type="ORF">M752DRAFT_200963</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">ATCC 13157</strain>
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            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1519" mass="167712" checksum="6FD5B08E5371B73C" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW36</accession>
    <name>A0A370PW36_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="470" mass="51417" checksum="D0910C5289A35F6F" modified="2018-11-07" version="1">MADAPNGGRIVPIVTTARQHYSSSPTDESMAKTTPQTSQKTKMPRNARNKTAEAETLEIPCLNALGLYALPTEGDGNCLYYALSDQTYGDFTHADEIRDRLADHISANKDYFMSFIAAAGGERRAPRRAAAAAARQSYCSSSSASPAPPSAKDKERSFDSKVAESRKKGVWGGAEEIQAFCQAFKKDVCVYTMYGIQNFRDVHAPEGEERDIIHIAFHDFHHYSSVRHSDGPHTGLPCIPKVGKEREAEASAAEPTVVDMATPWKISAIQEGLGGKYDQGAIVEMLQQCRGNIDRAFMNLLGEDSNTSLADAPSSKAIMKSRLQASSRSSSPFSVGSKRSADESDADDSPQPAVRRTRTRESKRRILPDVMVGIEFRDDQNDLVSLRLRVSPDTVVPKPAVQPSTEQAEASSLESATDSPSLLPQDRKLRIRSKTVSSETSSIPNESSDERKPPRRSQRISRTRPAPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWC2</accession>
    <name>A0A370PWC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61086" checksum="0FC1EE4B7575227B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWG6</accession>
    <name>A0A370PWG6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_317437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="495" mass="54263" checksum="9A0D0CAE2BDC0348" modified="2018-11-07" version="1">MPRLYTIVVALFAGTGTFLFGFDTGIATTTIAHESWKEYMRQPSEALTGAVVAVYIAGEAVGALIQTAIGDRLGRIRFMQVLCAIVTIGTVVQTASINIGMFLAGRLLAGIAVGGMVATVPTYLSEISGPAERGLIGGISGCGIAFGTMISNWVGYACSYADYGPKQWRLPLGIQIPWGIIMAVGLTTFMPNSPRQLLRQGKADEARQEFIRTHKDLPSYEVREEFALMEAQLEYELQTEIRAYREAFRAYRHRALVSIAVQTMTSLTGVNVIQYYQTILYKSLRIESHTILALAAVYGSIAFIVNVLTTTYLADQWGRRKMLLTGLAGVILIQIYTAVMQREFQHSNSQVGKGFTILGIYFYVTCYYGMLNSTTWLYGAEVLPIGIRSKVMGLAAASHFVVNVAITEAGPKAFANIGENYYYVFVGCTTVFLVLAWFYFPETRHKSLEEIASAFGDKVQAVGRVGPSEVHLRPTSGSPSFGSGFPEDHSFLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWX8</accession>
    <name>A0A370PWX8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TolB, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_280943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWX8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.60">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="649" mass="71053" checksum="3F1A0C268FD374BE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX01</accession>
    <name>A0A370PX01_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catabolic 3-dehydroquinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_227573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="237" mass="27365" checksum="AFE500FD57A53CDA" modified="2018-11-07" version="1">MVYNITEKETQPTIWSHINGSEGDILDRYCISELCKGWPVYRDASEWNHYRHLFVDKGAFVFTTWSGGLPIDDFIKTSIKGRANGDHIMHRENGTLVDLNPTTSRAIGKMKATITQRFNWDGVEFDVECDCRFINFCLKQGGDWKVVYIKLFYEKDRVTPADGQTVPKFDRAELEKYPKGYQYLAVAQAKLGHPILNDLPTMNNKSFYKLYEAMDAWMEARPVGDLLEIPEEASPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX13</accession>
    <name>A0A370PX13_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_244724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX13"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="34"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="497" mass="55113" checksum="0BF03230021BF2D9" modified="2018-11-07" version="1">MAFYAAARKRPHRSIHDPEVRPLRLAVLKAATINLLILQLLFLGLFCYLFGSIFQQTTHIHNLNVLFVDYDGGAIGRAVRTAYQQLQGSGFPTLREQSAEAYPNPASIVSAVCNIHYWGGFYIAANASSRLSAALTGIGTATYNTSDVMTLVWNEARYSTVVDSAIQSNILSLSEAARIVYTTTNGPSILQTVNTSDQTAIATLADPWTLSTINIQPTTQGSRLIYNTLVVILILIQEFFYLGYLNGLYQQFHLYTSVDAHRIAIIRQLISGIYTFIGSLCTTGAIWAFRYGWHVNGGQFMITWMALWLFAHLNFLVLDVFTIWLAPPFVPMALISWVVLNVSSILLPFELSPGFYKWGYALPAHAIFQVMVDIWSGGCNPQLDYALPVLFAYEVVGMVLSSLGVYRRAHYAVLAEEAKKESQERLAVEAEGEAEKETPGTNGGEGPAGEAEAEEGEPSEMQPEGFGERMRQEMSRLERVHTSRQNTGPSFDLPYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX77</accession>
    <name>A0A370PX77_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_333073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="383"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137286" checksum="4F194CE3502408AF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXD7</accession>
    <name>A0A370PXD7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_281639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXD7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="565" mass="61204" checksum="3520A9438F3B48AF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYD0</accession>
    <name>A0A370PYD0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_306567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYD0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39336" checksum="B1173469E43C41DE" modified="2018-11-07" version="1">MAPSRVDTPEPIPSPAPGKLQSIQTQQPQYGDFRDDFFRDGYAVIKGVLSKERASEYQSEALTWLESFGLGFDRNDKSTWKKENLPQSWKGGMYLHFSAAHEKYVWDVRCEPDVIAPFAKLWGTDELVVSFDTVNITLPQSIVGAYDSQPWPHCDQAPERKGLVCVQGIVNLSNSGPDDGGLIVMKGSAPLFDQFFEENPVTGPTPWRTAKHKDFHPFHDKDLDWYRERGCELIKVCAEPGDLILWDSRQMHWAQFGTSDLVRTIVYATYTPAAWMSEEDRQKKKELFEAYETTTHWPHTNLFTHGKAMVKVDGEEVVDPLERDEPLTKPVRSERLLQLAGVKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYS5</accession>
    <name>A0A370PYS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_323706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802214" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="25885" checksum="AD4DC3EE34F44FE5" modified="2018-11-07" version="1">MAPVRSSASWLSSVMAVCAILCLSVPANALYFYMDGRQTKCFFEELPKDTLVVGTYSTAVINQQSNTYNVDPNLKMLVTVDEIFDNDHRVVSKRDSHSGRFTFSAADAGLHKICVTPETNAATGGGWLSGAPSGAVQVTLDMAIGETSKIETEDKDKMQDIVQKVKDLNGRLQDIRREQVFQREREAEFRDQSEATNSRVVRWTLIQLAVLSVACAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q025</accession>
    <name>A0A370Q025_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_272036</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q025"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK47796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="684" mass="74718" checksum="5D3B89AC2810F258" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q070</accession>
    <name>A0A370Q070_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_244030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q070"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="389" mass="42910" checksum="1499E459AB89978B" modified="2018-11-07" version="1">MSAGPFPDFSASRSSQPGLYSLTGNSIDGKGGASLGKPDLLVSPAMDHTGPDEDGLPTNTNHSRMHNRNRSSVDGTKYKDGQWSPDNERIVLGPYDYMLQHPGKDIRRQLINAFNVWLKVPPESLSIITKVVAMLHTASLLIDDVEDNSILRRGIPVAHNIYGTAQTINSANYVYFLALQEVQKLNNPAAIDIYVQELLNLHRGQGMDLFWRDTLTCPSEDEYLEMVGNKTGGLFRLAVKLMQAESSSGKDCVSLVNVMGLIFQICDDYLNLSNTTYTKNKGLCEDLTEGKFSFPIIHSIRSNPGNHQLLSILKQKTKDDEVKLYAVSYMESTGSFAHTRDVVRELRAKALTLIQAIDGDQADGREDGAMVRAILNKITESTLGECGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0R2</accession>
    <name>A0A370Q0R2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qutE</name>
        <name evidence="7" type="ORF">M752DRAFT_299851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0R2"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF5">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="160" mass="17365" checksum="F955B3AE9A6D64E5" modified="2018-11-07" version="1">MELQTPTPKSILLINGPNLNLLGTREPHIYGSTTLSQVESSCADLATSLSCTFDSFQSNHEGAIVDRIHAARGSVDAIIINPGAYTHTSVAIRDALLGVAIPFIELHVSNVHAREEWRHKSYFSDKASGVIVGLGVQGYRVAVEYVARNWAPLKKEGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0R3</accession>
    <name>A0A370Q0R3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_288488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0R3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="58928" checksum="FF4E4E6DEFAD9618" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0W0</accession>
    <name>A0A370Q0W0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_10136</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0W0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="193"/>
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        </location>
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            <begin position="1"/>
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            <begin position="225"/>
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        </location>
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            <begin position="10"/>
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        </location>
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            <end position="982"/>
        </location>
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        <location>
            <position position="222"/>
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        <source>
            <dbReference type="EMBL" id="RDK48073.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119410" checksum="EEFE78E824BBAC25" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1L6</accession>
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        <submittedName>
            <fullName evidence="9">Acetyltransferase</fullName>
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        <name evidence="9" type="ORF">M752DRAFT_14413</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">ATCC 13157</strain>
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        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
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    </feature>
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    </feature>
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            <begin position="1"/>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK48347.1"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="702" mass="76753" checksum="1406FEBBFE6EDA84" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q226</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_300027</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q226"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="37457" checksum="171D2116E49B58A7" modified="2018-11-07" version="1">MLLDSIVPLRANATSRLAPGQQSQTSAGILTSTHSLLNKSFGSMRLRNRNSEVAKHQLDTVLSGLDYPRDSQLATRSNNSAHGMVTIGDGASQTRLPQVYLRADISGPENMNRNWIPHWSYQKSSIAAACIFTAVTVMAFTFLAILSIKKAIRSWERHKREKRDYANSGYSALSLLEEGHEMTSTSSKQISRETLMFSKSRSPSSPLFVEQDGPSVTRVYQASKSVSTITLDSPSSTLGHAGSTTELNAIPERPASALKRSRHERHGSKARSVVVVPSLLRAFSVKPMIHHTDPFHSLERTPLNVEHEGGSVPSSSKRDSAGGNSLFKLPAIQRTMSPLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4L1</accession>
    <name>A0A370P4L1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_110152</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4L1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="150"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="38762" checksum="3E1D42200C5B9DAB" modified="2018-11-07" version="1">MTLDKHSEHAPFSPPPPQPSPLTRSTQTTLTMNEATRNKLLKSYKTQVASATSTVFATLAVTPLENVKTRMQTHNFQNVAQCVRYLWRTEGPRGYVAGALPPLASVTAVRVMNFSTYAFAKNRVSNFIQRMTGESPLEIYDQEGSSPTVSTVITFTAAGLFAGLVSSPVACPFELAKNVVQTSVLMSHRSQASSNAPNDPSLRNMPRLSTTEAFRQIYKRYGFRGLYTGFHLHALRDTVGTGLYFGVYETVKQIAEREMGKGTGAPAIAGAICSTMPWFCTYPLDTRKTRAQSVLLGKSKEVGEAASAMAKSSIYKGLSIILIRTAINNMILLSIYEYMNKRIDNLDDSISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Q3</accession>
    <name>A0A370P4Q3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_242880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Q3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="434" mass="47366" checksum="64446EB4661A6219" modified="2018-11-07" version="1">MGIPLFCESSADAPKNNAVKDPCAAARSAIRRQATIRRPSRYGGSALRSATLRSPFPRPLADEIEREANGLQRHVRSPLSNSSSADDPFDLARGLLDSDRREAGQRLLSDALRHGRPGQRLRIPRSSALPDLYNRPSPGDDTTNRLDQTHLQFTPRFAPAIAYHRTASPQARPEAARLSPYLRPDGLGGDLSISAGFPTLRRVGERSINEANRPNRESAIDGLGDRQRSLSPDDDHANDAWETLLTTITPDTNLPSADSSFTSASASGTNASTIGTSRSSATSLQSLPNPMDSSTGTVQMVLDPYPEFLNPCDYSSSSDSDSDSETGISGNALFRRYRRVRQMESLRRAQHLQSTMSNHPPIPTISFAFSDSSSTSTDPDLQQMQAILDRLARREDIPEEWWAAAGLSRTLGRRLGANDDTNDTDSVDGPLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Z5</accession>
    <name>A0A370P4Z5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_287456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Z5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="38795" checksum="322BB62A0F82D291" modified="2018-11-07" version="1">MTSKLPSASCQPLADSKPGTAYEFHVDIQIKEGLDVSPGSWDILPSKFSGADSRYCRAENPRTHSLPGSVHMAIAAQQAAASSYSLRLWRDQRAELDPRGVQELECLSYCKVIRNRESATKRKHRRRGNLHGRKWIASTWADGRYGVNQRLQVVYPRTDLTSVEDLTGQGNWGTTAVAEVLAQNGASAMVKSHRMESAKANHEKRPGPEKTQWKGRNSKHGLAPSAWNGSKLLHIQAGRGFHEAVTALAPKMAVNNATAMRAQAGAKILYSNLRTRGVIESAIRGRQQQDVPKLSANRDGQADSWRTIKVKSRPRYLDRQRSDRSFSIAHAVVLAAQWVVVKLLGNGYGGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Q8</accession>
    <name>A0A370P5Q8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_279741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5Q8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="112"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="477" mass="54101" checksum="15A1D292656B7E94" modified="2018-11-07" version="1">MSKKPADVASKERNEYIPSFISKKPFYIDDDSQANDYLEHQRLQKSTAEQSKWYERGKRAGPAATKYRKGACENCGAMTHKTKECLSRPRKHGAKWTGKDIQADEVIQDVNMGWDAKRDRWNGYDPSEYRQVVEEYEELEKLKRVTKQDGDNEGKDGEGDDDEDAPQEEARYAEESDMGRQQSTATRNLRIREDTAKYLLNLDLDSAKYDPKTRRMVDMGAQDDQAAALVAEENFVRASGDAAEFEKAQRYAWESQERGAQKVHLQANPTAGEVMRKKEEAESLAKRDAQRKALLEKYGGQEHLDPTPLRDTMVVENEQFVEYDETGAIKGAPKKAAKSKYAEDIFTNNHTCVWGSWWHNFEWGYACCFSTVKNSYCTGEDGKRAFQEADQLLMLPENGDNADEPSGEHGEANDGHETIDDAQTSEQPKDSSNTNTKKRTLIEVQSGITEEEIESYKRSRLAADDPMAAFIGKDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P601</accession>
    <name>A0A370P601_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_339843</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P601"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK37301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="428" mass="46740" checksum="681C91E5EC094C16" modified="2018-11-07" version="1">MNPSSFRTASRHLHRLCRAPATSRNASVRGYATTFNWEDPLVASELYTEEELAIQDTARQYCQERLLPRVLDAYRNENYDRQILTEMGELGLLGANIEGYGCAGASTVASGLITKEVERVDSGYRSGMSVQSSLAMTAIHDFGTQELKDRLLPELAKGKLAGCFGLTEPNHGSDPGSMETVAREHPTKKGYYLLSGTKTWITNSPISDIMIVWAKLQTTGKIRGFVVERSQCPPGTLETPAIKNKTALRASITGMIQMDDCPVPAENMFPEVQGLAGPFTCLNSARLGIAFGAMGALEDCLSRARTYALERKQFKGNPLAKYQLIQKKLADAATDAAYGTLAATQVARLKDAGKCTPEMISMVKRQNCDRALANSRILQEVFGGNATSDEYHIARHVANLFVVQTYEGQSDIHTLILGRAITGVQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P676</accession>
    <name>A0A370P676_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_93037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P676"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="151" mass="16536" checksum="A86209E1BE5AFB15" modified="2018-11-07" version="1">MQRKPQERDNKGIKRGWSVAEKAKAKEWGKNSTERAGCDGKITQTGKVMSKPIERKSVVGPTGICNKALASLSTAEVHTSQECHMCRGINAWDASVKVADEIEGCYTIPQSGNDDKLRRSSELRRSSKMDCFGLRGKEVRKVGGQIVGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6E4</accession>
    <name>A0A370P6E4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_287098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6E4"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="655" mass="75007" checksum="E2FAC27229FF3B4F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6K2</accession>
    <name>A0A370P6K2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_270715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6K2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="33751" checksum="237103B8385AB1B7" modified="2018-11-07" version="1">MSSTPCTACSWTPERQKYCSYESYLKLFYEAGDRGVWSIGSKVILKDRGSNLPTSEVPNIQFVQEQTSIPVPTVFESWEEREHTLILMRRIPGEPLSNVWSKLTTEEKERIAKQTAEYLRQLRALQSDKIQCLGGRPVFSNFLFKNKGLNEVPRGPFASDDELWAEMERGLNEEIPEAARVRLRQCMPSAMPYTFTHGDLTNVNIMVENGELTGIIDWETAGYFPVWWEYVCTSVPDSEEDREWKTLLRQYMPDYRVARVFWLEYYYLCRDLDSERAKKFLGKIDETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6L9</accession>
    <name>A0A370P6L9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_89789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="826"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1862" mass="205938" checksum="D197847AE71521FC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6M8</accession>
    <name>A0A370P6M8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_279646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6M8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="533"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="603" mass="65192" checksum="9B71DE6D4307E0DD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6N7</accession>
    <name>A0A370P6N7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_287068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6N7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811668" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="8">
        <location>
            <begin position="35"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="860" mass="96074" checksum="22D8D8725BB11A83" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6N9</accession>
    <name>A0A370P6N9_ASPPH</name>
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        <submittedName>
            <fullName evidence="10">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_286967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6N9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="504"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="822" mass="89513" checksum="B03A3AA0FEEB4460" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P785</accession>
    <name>A0A370P785_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_223566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P785"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="329" mass="35955" checksum="35C2040FA8E19D8A" modified="2018-11-07" version="1" fragment="single">QRKKANEEGGVEKLPSGRDASYAAESSLIGDTTAAVLRLQHFTSTACPMWISIALPFTASSSTRCWLSFLLGQRMSTSRYDDVLSPKGPNCLANIACPGGWRAEIGVNSELRNGPTCPRGRKHNNLVGIDAIAIAAKTLEGTDTGTVTVQMGGCGCPRYHRLERVQSYHECRCDPSDNLCRLQTLGPRGSSLSRDSITFSTVGKSKKFWEIQQEDKRGSPSKAINLTSLRWNRALVESTDCALVLALHCIAFALPYSFVVSSSGLPLPPRLMMALPGKLSLHYFEPYLVMSTSTGQCEAASETQREKCEMDSVVLQYQRQKGPRWLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8G4</accession>
    <name>A0A370P8G4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_269966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8G4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62296" checksum="D4E085B08951DF3D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8J2</accession>
    <name>A0A370P8J2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_80340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8J2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="447" mass="50016" checksum="2531DEADEAA54E47" modified="2018-11-07" version="1">MDDYLDVFGQQTFTINIQSCFCFPLPDNSACPEIVGTLTKGLERLRTSFPWLAGQVVNEGSGDGDTGYFMIRPLENEAQLVVRDLQNDLSVPTMKDLQRANYPISMLDQNILAPRKIFPENQDDSKPVFLIQATFITGGLLLTFVAQHNAMDATGLVNIIHLFAKACRNEEFTDEELRDGNLPRRDIVPLLDDSSATDAELDRYIVKTAPYKHSTDLPGTRMPKFSWTSFKISPRSLEELKSVAMASLPPPSFVSTDDALTAFIWQSVTRARLRRLGPSTHSTIMRAVDVRGLLDISPLYPGPIQSNVYTDSSIMTLIEEPLGNIALQLRLALSDESRLEHHTRAIATFLSRTPDKNIFSFGASIDTTTDLIFSSWAKLESYCFDFNLGLGLPEAVRKPRCNEVEGLTFLLPKTREGEIIVAICLRDEDIEELRSDVVFIKHAEYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8K4</accession>
    <name>A0A370P8K4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_279064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8K4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="313" mass="33636" checksum="DD1205FAC1104975" modified="2018-11-07" version="1">MSPKSILVLSATGNQGRGVVQHCLSAGHSVSAYVRNPASSAAVQLAEQGAALITGDLDDLESLRTATQHVDAVFFTEVQTGNRELDLKRMENVILAAQESSTISHIILSTALKTGQHESFPGWEGGAHPMKEYWLQKHALENRVREAAAAKNGGRWTVIRPGHFLQNLLPPVRDFMFPGFKEERVLRVAYRAGTELPLVDARDVGIVVAAAVKEPERFANKAVDVAVEVVTVEQLAGKIGKVVGEEVKVEFLDDEVVDGMIKEGHLGAASSRWADEVPGGDGVSNCREDLGALAEGLTSVDAFLKENGKEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9T0</accession>
    <name>A0A370P9T0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_239560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9T0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54997" checksum="CA59B01C1218BCD5" modified="2018-11-07" version="1">MNYRMKRKLGKLRFRKCKALAKHGGKCKKRATSSGFYCHRHKHLAVENKKDFPPHLIVDKPQESRKEFDCGSPTSKVHDITPDDMVMSDVAVADIPIDSNSEIDAPLRATPELTSGPSDTSYGDISQGQDLSSGEGNGNVESSGRSDDQDDAAVAVAYQQRKPDLPHDLPEQEFETKSDRKSAFNSTFNHNSGNSTNTNCGNTTNSNCGNSTTNNDASQNFHVEGVMAFITNNYSGFSIDDQTIKTLMRTAAAEMMNIVQTYNIPAGKEKSMVELALFDMVIVCDNSKSMLLYSDAMKKTLRHLVTISSLLLPKGITIRFLNTNHDGKDLYENITEGYQVDKICQNAKYFRFRNGPELGDFVNEDIIHPMIMRKARAGELKRPVITIMLTDADIPSAQGRETFKSCIRSCKKAADLQKYGDKAALFVLSRVGNSRRGKEFASELESDTSINDMLHCSTDSLDKWLADCQKLGKENEYTGKLIELFLTALDRNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Z5</accession>
    <name>A0A370P9Z5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_190410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Z5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="45657" checksum="5CD4A3F8AEE2C886" modified="2018-11-07" version="1" fragment="single">MTGIAANCNRWYTAQKGDNCYAVEKAFGLTPQQFQQWNPAVSLDCLVNFWAGYAYCVGVGPAANGPHGPTMPGIAPNCIQFYTAKKGDTCYAVEKAFGISPQQFQQWNPAVSLDCLVNFWPDYAYCVGVGPVAPTLTSTVTATATSASTSTTLTTSTTTMVTTSVTYSTRNPITSYNQTITPIDTAWPPTKTHPGQPKNCDKWHLVAPGDTCRSIYQRHGNSITMDELLEWNPDLKADCDYPIAGYWVCVGIKRPALTIIYPTTNGTVPDPTPWTPRPFPTETAVYPPTKTQPGLAPSCSAYYEAQPSDTCDQILASNPMLKFPLLFEWNPALKADCSGILPGYFYCIAAYNSTNLPSPPTVTNQPYPMKAGTAKNCTAWYKKEDGDTCDLIVEMFGTFDKAQFVAWNPAVGVKCIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAB9</accession>
    <name>A0A370PAB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_221499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="483" mass="54804" checksum="E59DC73FF57510AA" modified="2018-11-07" version="1">MVYRGRPSKSCRECRKRDIKCDKKEDGCSQCVRAGLKCSGYQKLTDIVILNETSATAEKVLRKHYLEGPASAGPLSTNLLPTVLQRAKHLYISQYVQDTPATGIYSYMQVFYPSKSDDYPLLETMIHALFMATFSSLQGWPPALYHARNNYGSALSLTRKAIRSPKEASLDRTLFSVLLMSIFERLANVEQGALCIRNGHLKGAFELMALRGNSQFTDEGSVAMFLHLTELVVLDCLANEVDIPSRFLALRQQALEAGADTSSLRWRFLEVMMWYAQLEYTAKSSTSAEDVIYQAKALDAELDRLSTHLSSFFSRKQSPEAPSIPPTKPDIYPDYNTQRCWNNIRILRIQLMKLIRDRCAQALGDSADDTWIMAEVHDSNRRANFLATDMCLSIPGKGAHSMLLYEVSNVQSATLLFHLHVAKEVLPNPAQSRLSIQERLQFLKVKQSPSQQRTLDCLLHNDYQMPRNIWRVWLLIGREDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAD4</accession>
    <name>A0A370PAD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PFU-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.870:FF:000003">
        <property type="entry name" value="Polyubiquitin binding (Doa1 Ufd3) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000377">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="499"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="783" mass="84316" checksum="68650747E80BFED5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAE7</accession>
    <name>A0A370PAE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_338480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="228"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK39139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="418" mass="46026" checksum="6B13D7D99BEC9319" modified="2018-11-07" version="1">MAEGAFLGTCVHCAELLANVPLSVLLITLVATLAGLSVLFYITLYTVAPVPRKPFPEEKKYRTLLKDGSITEPLELPCWQDALDAQRRPGRVLDHTSMEEADLFMSLVVPAYNEEDRLGGMLEEAVDYLEKVYGTVTNSANGAESPTAEKAMRQRKQANGHTNGSAAHRPVHDNKGWEIIIVSDGSKDKTEEIAFTFARDHQLSMHPKGYAGPWTPGTHEGVRIPPGTIRVVCLTENRGKGGAVTHGMRHVRGQYVVFADADGASKFEDLGKLVAACQETEDVKGRGVAVGSRAHMVGSEAVVKRSKLRNFLMHSFHLILWLLTPSKTATIKDTQCGFKLFSRASLPYIVPYMHSEGWIFDVEMLMLAEFADIPVAEVPVGWREVKGSKLNVLRDSIGMAWGLAVLRAAWLLGVYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM9</accession>
    <name>A0A370PAM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_338554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="163" mass="17395" checksum="E81E52C89EB96EEE" modified="2018-11-07" version="1">MAHTLDDYTIAWICALPLEVLVTSSRSGTIWPVLGIQPLNHLQHATQIIVEATALLELDSTKRAKLPGTSLEAFLNSVINLAKKAREQPSGQEILGKLNSLQPIVEDIILIKNAVNNALASPAPVAPNAATRIASWADVVRSGAPSYPSTPNSRASTNRKCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAN3</accession>
    <name>A0A370PAN3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_268863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAN3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="44419" checksum="BC65889EA32486F7" modified="2018-11-07" version="1">MDIISGHGREYNHSAPPEPAELSALLIRGWEAIQLNSASSRSQNAPDRSENAKFLSDLADYDNSRGAPWYLQMFLCFLRGIRQQARQTTSFILEISKKKGPTPGPLAPDDVTANPKVSLRNTFPHEHPYNCQPQKTLTTTMNKITGALIDEATHIRAIAKDVVLSGTYFYPIKGIIYTLNRPTLRQPLLSRSSKTLTLGVGVTTAMFFFTYVPQAAIMSITSGPLLAPFSAALLVLSESSTITTFLARSFLLADAITATFDATLVEMGQERLLEQSGKGGGGDDAIARLGSKEEVEERQTNMWNMLGKKVGEGVHERWFALKGWKKGDRARWVGRWRGKYTGFGMAAFALEMVPFVSIAFAFTNTVGAALWAADWEKSLQQGHDWPLGYFIGEPFFTQHWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBK7</accession>
    <name>A0A370PBK7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_50328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBK7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="98" mass="11342" checksum="C7162EC35332A7CA" modified="2018-11-07" version="1">MIESLKKKKKRSRSCNNCVTMHGLLLFNTWCMEESTGLYLPSQPDMQMQASRYLQTSTHVNLLFLFLSCSLVILDHALVRSQVCSDIPHRRSLISRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBP4</accession>
    <name>A0A370PBP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ab-hydrolase associated lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_278105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="636" mass="71480" checksum="DEDD55BA3CB2A08A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBR2</accession>
    <name>A0A370PBR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="97"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31546" checksum="229216CAA89C081D" modified="2018-11-07" version="1">MSPERVTTEPLHSPDWDNDWLRQLAGDIVAGSLSATIIAPITTVIDRSVVERLSSNRSILHTLRTHAICSILKPRKFYFSRPFFIAWSLYAATYATANATDTSLEHLSKVTEKSTTASLVPTFSFLPTYVVNVCLGILKDIRFSQIYGHPEGRLKQPPPIPRLAYMAFLFRDSITISSSFTLAPQVASLVPDWITADPHTKRTVTQLALPALVQYVNTPFHMIALDVIARPQVATIAERSVTIRRGYVQSSSLRAARVLPAFGVGCIINTDLRASLHERWMVR</sequence>
</entry>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="prtT"/>
    </dbReference>
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        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="62"/>
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            <end position="37"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="58"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="75778" checksum="3B397076BB01FB13" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBR9</accession>
    <name>A0A370PBR9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_328835</name>
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    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="AtrR-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="709" mass="80079" checksum="D0CD01801CE64851" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCB6</accession>
    <name>A0A370PCB6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_53166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="809" mass="90399" checksum="DE3F152B00385D5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCC7</accession>
    <name>A0A370PCC7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_254666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50185" checksum="C0DDBF40952F0FA4" modified="2018-11-07" version="1">MVFTGLIVDAQLDEVVLRQTAAQLVKAWPALGGQLYRSSRPYALSSGSTVDFESRTLPKSATSWKRGIFHSRECNQPIISDSLNPEELDDAFIVDVPAAPANVFLIRATLFRDATLLCFGISHHLADGTAAYDVIRAYCDLLAGSPIPSLLLPPDACGQRMSDRVLLNDKHERSLRSITYAEHLANFTAGFWPILLLMIRVIICLLLRKLCLQETLEERYIYLPDDWVGAVHKGALNTLAAMPVGAQPSWDTQPTRNNIINAWFLKWVYSAIPSSRADMYFYGPLSYRGVVEPPQPGAYWIHNSIGLVRHKLSVAQIQNEPVAMLAGRLRLASLRFTCPASIKAFLQMCEDHASQQMLPRIPAKGRIPMVMVTTWTGFDFACLDFSSAACDRSKPAKVLFIHPLVRSLRQGVWPSAYTLKSAQGGGYWLRAWNTLSGWKKFSQMVDVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCD3</accession>
    <name>A0A370PCD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="152" mass="17504" checksum="0F0DC26C20BAB2FD" modified="2018-11-07" version="1">MSVDADQETPLSGTASQTPSFALNTTSDTDESHAVDPSSLTTYEKRLYDFLCSQEWTDTQCSCFIAHIEQMKEALSHHFYSQGWNTVQVQRLHEQCEMEFPEHFPAPRGDAEQQDLQMQLRFVEEMNRRRAIGESMYPSIGTMDGEIDERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCE6</accession>
    <name>A0A370PCE6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_254700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCE6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="49887" checksum="45495DCBE64AF707" modified="2018-11-07" version="1">MLLPRRLLRPCSLGFLNSHACQLLLIFILFYGLAINLARLTCWRDPTSAFFTEDQAYKPAYSTLRTEQANALIQQANSNTIPHHFQTKASSHPTMCVGIASVARKGGNYLQGAVGSVLEGLTAAEREDIYFIIFIAHSDPAEHPAYMEPWLHDLADKVLVYDPDLVDIEQIRSLETPEAKKFAREKGLFDYTYLLKTCGALNTSYTVMLEDDVVALDGWYHRTKQALDVAERKAEEEGVDQWLYLRLFYTEIFLGWNSEEWPTYLFFSLLTAAVVVITTTAIRYCCPATDRYLSNEIITVLSLVITPLLIVLFFAAGRNTMLPIPEGVHAMPKFGCCSQGFVFPQTRIGDLVSWYERNKVGYVDMLTERYADQNGEVRWALTPSVLQHVGSRSSKTNSLGKHRERLTMSERIWNFRFEENDPGELRLEHRLQDEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCT7</accession>
    <name>A0A370PCT7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_46830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016478774" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="582" mass="64140" checksum="38C3800F47B89023" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCW7</accession>
    <name>A0A370PCW7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF167-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_47005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="126" mass="13743" checksum="9F9696CB63A68789" modified="2018-11-07" version="1">MSTSPLLRLIQTATTKSRPNNPLYTLQISCHVKPNASSNREGITAIGTDRVDVCVAAVPRKGEANAAVSRVLAQIFQVPKSNVEVIRGLKSREKTLAISELDIGKQSEDEYLRRARGILEGAVMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCZ4</accession>
    <name>A0A370PCZ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_337804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCZ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00165">
        <property type="entry name" value="HTH_AraC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="29236" checksum="D379D2C725BAE5D3" modified="2018-11-07" version="1">MVPPPKLPLPKPSLSPSSTSPSTRWLAIQTRDPKFTNAFVYAVLTTKIYCRPTCPARLARRANVRFYDTASQAELAGFRPCKRCKPEIVINNSNNLLGAGSNTTTTGSGTFSTTFHPQIPSVQRACQTIRASVQAGSKPTLRMLAAEAGLTPSHFHRVFKRVMGVTVGRYVVDVMRKSGDGEVLEGSCRDWVGGEGEGAGNWPVLWNDFDVLLAAEEEDGFVVPTTVTMQDVQPVVPVQDEELLAWRAVGSYGVGGGCSVDETLALGHEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD03</accession>
    <name>A0A370PD03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Elongator complex protein 3</fullName>
            <ecNumber evidence="17">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_219371</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD03"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="101"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="415"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="65011" checksum="3859BED9D742B796" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD13</accession>
    <name>A0A370PD13_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-C domain protein HetC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_338091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD13"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009259" evidence="2">
        <location>
            <begin position="29"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="814" mass="90623" checksum="98653C0D0B899C48" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDA5</accession>
    <name>A0A370PDA5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_254161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDA5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="2">
        <location>
            <begin position="507"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="644" mass="71048" checksum="7107F731DB46288F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDR5</accession>
    <name>A0A370PDR5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_337489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDR5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016785757" description="Glycoside hydrolase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63455" checksum="32590D8064E38A42" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDY0</accession>
    <name>A0A370PDY0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_285181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDY0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31655" checksum="AF14116D596ADAAE" modified="2018-11-07" version="1">MASASNEHFKLENLFGVKGKVALITGGGSGIGLMATQALATNGAKVYITGRTQEKLDRVASLYNKNISGEIIPIVSDITSKESITKLVKEIESRESHLSILINNAGISSSTDNTEPSEAQDLKKTLFDEATPMSEWEDTYRTNVMQLYFTTTAFLPLLQKGSEREKGWSSTVVNITSISGIVKVSQHHFAYNASKAAAIHLTKMLAHEVADSGLRIRVNNIAPGVFPSEMTAGESDETQKSHIPKEKYEGKVPAARPGKDEDMASAVLFVSTNQYLNGQTVVVDGGYVLAAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE50</accession>
    <name>A0A370PE50_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha,alpha-trehalose phosphate synthase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_277754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE50"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="926" mass="103970" checksum="FD22C87E73E7A8AD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE81</accession>
    <name>A0A370PE81_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_277776</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE81"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK40493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="408" mass="45627" checksum="9D48CECFAB17FBC6" modified="2018-11-07" version="1">MSPSDTPPGPVPFGQENAALQPTPTEWSLKRLWNRTSLPYKAGSSVMPGGSASQAAQETTKESRGASIRWAPLNVGLERRLQTLVVLCHTLTIAILLTAFFFVCAIPLFWPIILPYLIYISLFSTAATSGDLSGRCDFLRSLGVWSIYASYFPARLHRSEPLLPTRKYIFGYHPHGIISHGAFAAFATEALGFAGLFPGITNTLLTLDSNFRIPFYREYALAMGIASVSRESCENLLSKGGIDGEGMGRAVTIVIGGARESLDALPHTLRLVLKRRKGFIKLAIHTGADLVPVLAFGENDLYEQVRSENHPVIHKLQMLVKHTLGFTIPLFHARGVFNYDVGLMPYRRPLNIVVGRPIHVVQQRDREKIDDDYINHLHSLYVQELERIWEEWKDKYARDRTSEIEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF5</accession>
    <name>A0A370PEF5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="1">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="43173" checksum="D604079EDA2BAF02" modified="2018-11-07" version="1">MAIHPNFPSEVNPRGSLSPQQARAISVWTEQAAASLESLTLSESVPIADSNVAFAQSTPTRAGVRGTTVSLSIPLDDPVPTAGSPFAPKVKALGQPTKETQVASVTFRRREPIRRDSLKRREALLKGKDGSRRRQRWENDRLLNNPWAEPPSSKDWDIQATHTRHDPLPYYLAPLWDNHYAHLDHRSSQQMETRTEKHRVPKELRQRLKHARAARGILQDIEEDIRQFIQRWNEKQSLLKQEGLADAPQSSDSESEDEIVFVGRNGLMHDSPQRRARLQKMREAMSAHHEHDGQKMVFESLVDDRAAGFGRWLVHSIASYYGLHTWSVTVGEPARREAYVGFYPPAPSSRAGPISPPAGSKACRQEAMIQPGDELPQPLWTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEJ3</accession>
    <name>A0A370PEJ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653905" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="110"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="29271" checksum="D976B991BBDE2B79" modified="2018-11-07" version="1">MRSMSRLFILCLLLLLGTVTSAWPWRPHGELLRRADTTAAESATTGAAATTESASKTEAATKTAAATGTDTTATATGTNTKSATKTGTASGKSSGSSSNSTTSVSINPAAGAGGISMLIPTEGATSYYKIGDFVTLEWNYTSLTISPTAVNVVASCSLNSATYTISSNMTMSPTGKVVWDTKKYQANATVPLLTASYTLIVWDASKAITETASAGYLSAASSYIFGMYSSQPYTPLNGFVCATCSGAFSELERLGMKFTFGMFAITVLSFTWFAGGFGLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFF4</accession>
    <name>A0A370PFF4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_277033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFF4"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
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        <ligand>
            <name>phosphate</name>
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            <begin position="68"/>
            <end position="69"/>
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        <ligand>
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            <end position="102"/>
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        </location>
    </feature>
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            <position position="240"/>
        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="311" mass="34015" checksum="B7C54D3D81A6F5C1" modified="2018-11-07" version="1">MAALPSTYDEPVRIAVIGGTGLRELPGFTQVASLNVSTPWGTPSSPITILHHKCSHNNQTVAIAFLSRHGLHHQIAPHEVPARANIAALRSIGVRTIIAFSAVGSLQEEIKPRDFVVPDQVIDRTKGIRPFTFFEGGVVAHVPFGDPFDEGVAKVVRACGHSLEGEGVVLHDRGTLICMEGPQFSTRAESKLYRSWGGSVINMSCLPEAKLAREAEIAYQMICMSTDYDCWHESTADVTVEMVMGNMKANAVNAKRFVTAVLDELAAEKNSELVQAKHIEGSVKFGMSTAEPNWSPEARERMNWLFPGYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFY9</accession>
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        </recommendedName>
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        <name evidence="7" type="ORF">M752DRAFT_277155</name>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
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    <sequence length="143" mass="15410" checksum="41909DA5A39E3E04" modified="2018-11-07" version="1">MVPSQVNGLRILAPAPDTRPSRVTDVAVRPAKRKSNACDACKKRKTRCHGDHPCDKCTQAGTKCLFAGDVDKRKKLALHNTEQELNAIRSLLDQLVAAFDSGNDADIQRLIDIAKSKVNTKIPSCISGAASRTCNHSLASTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
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                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RDK41275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="84"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="619"/>
        </location>
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            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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            <begin position="1108"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1211" mass="131653" checksum="4C7C5BFC55E4CE2F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH0</accession>
    <name>A0A370PGH0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_284194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016795097" evidence="4">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="108"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="44418" checksum="18833D390E1E0A50" modified="2018-11-07" version="1">MQLKWLTLVCLSSWPSARALYNQSTGFPEQDIDNGVALQQIADNALNNMEQESLTTNGCRLEDAQIRREWRSLSLNARKEFTDAITCMQSRPTNISAEEKETFQGVQTRYDEFVATHINLTEHIHVTADFLAWHRFFIHAFENALRVECNYTGTLPYWEWGLDAENPQDSVLFNGDLYSMGTNGVDLNRTSIYWASQNITIPAGTGGGCVYGGPFSNYTVHMGPIDAPGEQPVQYNLEYNPRCLSRDVNPSVSRMSNSFRNTTKLILSYDTIDWFQGVMQADQRFTDPTAPFSYGVHGGGHLTVGSVLADIDTSPAEPMFWLHHAQIDRVWTIWQGLDPAKRRNAIWGTSTRGDDPPSANMTLDDLLNFGFISQPLKFADLMNPLSGPFCYYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGV5</accession>
    <name>A0A370PGV5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_26524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000042">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="98" mass="11264" checksum="55BFF2812830AA97" modified="2018-11-07" version="1">MLFFSFFKTLTNQTVTIELKNDIRIRGTLKSVDQYLNIKLDDVDVLDLDKYPHLSSVKNMFIRGSVVRYVMLPRSEVDIGLLEDATRREAANQAGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHV5</accession>
    <name>A0A370PHV5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="210" mass="23750" checksum="7E7AAF9D7342324D" modified="2018-11-07" version="1">MPSFSSTFSSIFKSSNEKKTTKKTSSATIEMSSIPTSSKKTTTTIAHHGKNINHVNNNINKSDNKIAKDNYNNRNNKTADKAMKSPDNNYYNNNITATATATATNNNNRNNMSDNDYNKNNNNIIATNDSEPVDLGIPRRGQYVTRDGIDVVAVLETWHQIYTGWQIVSAELDRMEKMRERRFICENGSPRQRKQHSQSVGYCVEMHGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIH2</accession>
    <name>A0A370PIH2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_276672</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell tip</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 17" id="KW-0518">Myosin</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1419"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1454"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1480"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1702"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1760" mass="196314" checksum="D3024E8CE01CF0C9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIR1</accession>
    <name>A0A370PIR1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_24365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIR1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="26381" checksum="71B936D10444CD25" modified="2018-11-07" version="1">MEAEYIRIAEAIQQEARKKDKKRLLVAIAGIPGSGKTTTASAVAQQLRAESQPNKIALISMDGFHLSRAALDTLPNREEAYIRRGAPWTFDAVRFITFVKQLRQWADSTPFPTDGGSSSNATVIYAPSFDHEAKDPIENGMVVTSDASIIIIEGNYLLLNEEHWRDVSQLVDYRIFVDADLQEARGRVARRHVSAGIEKTLEDGFRRVDSNDYLNALHIQGKLIRPDMVVKSVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ24</accession>
    <name>A0A370PJ24_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_300201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629232" evidence="5">
        <location>
            <begin position="20"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="594"/>
            <end position="595"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="615" mass="65161" checksum="D77850FB55CCCF33" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ34</accession>
    <name>A0A370PJ34_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_251292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ34"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="9"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="38872" checksum="9EB8D56C6EE8CC5E" modified="2018-11-07" version="1">MENPSFVLRNIKDVVIEDRPKPILKDPHDVMVHVAQTGICGSDVHYWQRGRIGDFVLTGPMVLGHESAGVVVEVGDKVRHLKPGDRVAMEPGVPCRRCDYCRSGSYNLCGDTIFAATPPWDGTLAKYYINAADFCYKVPDNMTLEEAAMVEPVSVAVAVAKTANLQAHQTVLVLGCGPIGVLCQAVAKAAGARTIIGVDVIPSRLEVAKSYGIDHTFMPSRAEPGTDPMVHAERVATQLKEELGLGEGADVVLECSGAEPCVQMGIYAARRGATFVQAGMGKENILFPITAVCTRGLTIKGSIRYLTGCYPAAIDLIAKGKIDVKRLITNRFPFEKAEEAFELVKAGRADVFKVMIAGVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJE7</accession>
    <name>A0A370PJE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_335939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16776" checksum="0E939D87F47F908F" modified="2018-11-07" version="1">MASFKYHALPGFGEECREKYGFSDACIIGNRLVVTGQTGMNPLTRETSPKIEEQIAQAFNNIYDLIIHTLVQEGHAIEENSTGWDYVVKLRAFLVGLSGMRVEARENMVHNIKKWCPRHQPLFTMVGLESLPFPEHLVEFEVDVWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJH2</accession>
    <name>A0A370PJH2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_234345</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJH2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="365"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="711" mass="76837" checksum="44388F0D5790B09C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKB3</accession>
    <name>A0A370PKB3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_283725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="532"/>
        </location>
    </feature>
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        <location>
            <position position="132"/>
        </location>
    </feature>
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        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="546" mass="60962" checksum="1C2C27A27A209A7D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKJ7</accession>
    <name>A0A370PKJ7_ASPPH</name>
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        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">M752DRAFT_250630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="719" mass="79803" checksum="E775C73D1E098CFA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLM2</accession>
    <name>A0A370PLM2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_167112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLM2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="9162" checksum="C9072CE4146CFD9A" modified="2018-11-07" version="1">MRFLRFVCSFPPTQSGLFPPLFSSPLRAHLNLIFLFPHLPIFIRFLFVNLVLLPAPYSHTLSLFGFPGKWFRFAPSHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM63</accession>
    <name>A0A370PM63_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_326148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34936" checksum="4A0EEFFEA48280AF" modified="2018-11-07" version="1">MSSMRNAVQRRNHRERGQLEGREKWGILEKHKDYSLRAKDYNTKKEKIKRLQEKVRDRNPDEFAFGMMSSSSARQGKHGAAGNRDSAAARGLSHDAIKLLKTQDAGYLRTVGERIRRQMEKLEEEVRLQDGMKEILDGDAGEDKKKEEDVMDDDDMDFDFDFGDDEVDQKKNKKSRKLVFADDRKEQRVLKKKKLREEEEDEDDNEEEDDSFGKQVMKKSRKQLEAERQALVEARRARKMKKRAAEARMNKLKALQKQYKEITAAERELDWQRGRMDNVVGGTNKNGVKWKIRERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM84</accession>
    <name>A0A370PM84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_155645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="426" mass="46552" checksum="89D877368D39D1A3" modified="2018-11-07" version="1">MKRIFNSFSRRSSPARDSPSYPEDSPESIILREVTAFCESGPNSANGDEFVHLPAIVESAESSPNAAREAALRISKLLSNPAKTRSNVQYNAIMLMRILIDNPGHTFSRNIDVKFVATVKDLFRNGRDMNVHTFLRDTLDTLEMQRSWDEDLALLLGMWSKEKDKYASKNTGNPGLTQPLVQPYRQTPNYYNAPSQDQHGGLPQPEELSARISEAKTSAKLLIQFVQSTPPAEMLENELIKEFSDRCRTASRVIQNYIHSTNPAPDEDTLVTLIETNDELSVALSKHQHALLQARRAQGQSGSQSPASSSQASSSGAVQPPVPAAGASAPPVPPRNQTQSPLSSGSSSTAPVLPRTYSNGAGRFEYRSEDYQVQNPFADTSATAAAGTAPVAPVGHGDEHQARAEGSSADWWAEGQQQQRPVQQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP9</accession>
    <name>A0A370PMP9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-22-like protein Pex22-like-Penicillium chrysogenum</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46885" checksum="59D16313D97A6D3A" modified="2018-11-07" version="1">MSFPYSQDARRRRVGAGAGFSSTGNRTVLGYWVPLAVTVGIATVSIAAWIWSERSEDDDDNNNNNDRDANPPPHDGRFPAPEGYPHGEYADDYARSTATDIPGAMPDDASMMARMQGALRRTPSPQQIFDGASKKVAAGVAAAGAFVGGALTSIREEDRGDFEDHSRWSEEVASRAQRAEQPAPTMTGALPVRDVGVGGPASVTRKRTVAIVVSSESAQVDPDDIVSQHVSILSHLPEHVNLDTARVFIMIYAPGLKHAPKQGSSSQPDLSVASSYSNIAPEEAVASGELPEGESPSESRQVDEEDGSTPLFKTLYTQAQALVEKENTIMPFSTATGYVHLVRHLSPEVVYVQESLTGESGEHVKLFSGWVRETVVVVGGEIGHGGLVDSDDESALADKGEKWWQKEGVTGLGKRINVVDVHRIGDDWRRRVSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN06</accession>
    <name>A0A370PN06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TAPR1-like"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="28682" checksum="B45C20AE58B72EA0" modified="2018-11-07" version="1">MDSMRSLNTSLPSSTPRPQPPEQLLQSFKAAALSVTNLYKNAVYEQSQAKQAGYQEAIEDLLHFLDRENLGLGDGEGWKVRQWATERSDGTGAPSDDDEVEKQTRGATPAAARKVQPESEPIRQPSKLSSEEQAPAPPQQQPPAPSPPHASETNDFDRPTIFTFTAGPTFPQFPEQDLDMQTTDSSTPASQDGAPVSVSVLPRNSRQQNRHNNFTRSNTRSSPLEPSVGIGSKRKMNVPDFFDLSGLGNRDMFGGGKRGRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN07</accession>
    <name>A0A370PN07_ASPPH</name>
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        <submittedName>
            <fullName evidence="4">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_265432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720087" evidence="2">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="44661" checksum="8B082B9E084ACCFF" modified="2018-11-07" version="1">MVALKALSLGLLASQAWAVPTTSQTALSSPAASSAAVAAAAAKLEQLSSYALDQTLANLPSSSEDSEACTRETLRIRRDWRTFSKPEKEDYINSVLCLQELPSRTPSHLAPGAKTRYDDFLATHINQTLEIHYTGTFLAWHRYFIYEFEQALRDECHYTGDYPYWDWGYDAIHTMEASEVFDGSETSMSGNGYFIPNQGNISLYLGNYPAIVLPPGTGGGCVTSGPFKNYTVNMGPAALSLPGGSTASVSNPLNYNPRCLKRSLTTALLQRYNTYPQITSLILDNDDVWDFEMTMQGVPGSGSIGVHGSGHYSMGGDPGRDVYVSPGDPAFWHHHGMIDRVWWIWQNLDLKSREYAISGTGTFLNEPASKNTTLQTVVDLGYANGVPRRMKELMSTTKGLFCYAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNN3</accession>
    <name>A0A370PNN3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_249143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNN3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="516" mass="56603" checksum="42D86FFF57DB20E9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNP4</accession>
    <name>A0A370PNP4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_232043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
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            <end position="417"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="730" mass="79511" checksum="08CAA515D87BD57A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNS5</accession>
    <name>A0A370PNS5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_292004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="220" mass="25441" checksum="37E0982C0813B049" modified="2018-11-07" version="1">MGVSNPVKYVLRLSLFTNKRTEQQQHRQHHSSSPISPISPSTTWKGKEIDSDPPIEVRWGAVQYPDDYAALTDVHAHMAVSAIDSDLGSSSSSSRSRSSGSSSRTGLVRVVSWASLAGDRCRWTMEQERRLAIARSELARCQKAWSSEQELWLAQIEKLHEEKEAHEQFIHHRAKQQDEEQQHFRKSWIRRKSYEEQQQQLVPTTQRTNSRLRRIRRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP27</accession>
    <name>A0A370PP27_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_248921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP27"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 CBM87" evidence="2">
        <location>
            <begin position="143"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="1">
        <location>
            <begin position="369"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="3">
        <location>
            <begin position="736"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="804" mass="86220" checksum="CAE7B66A0EA0E484" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPT0</accession>
    <name>A0A370PPT0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_318033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="64"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="424" mass="45603" checksum="A3E8FFDFA03C2F8E" modified="2018-11-07" version="1">MPGKTSTSLPRITKFTNCRIVKGLDLVEQDVWIDSISGKILKDQEAFYGLHLSPDKVIDLGGRILAPGLIDVQLNGAQGFDFSVPQASKELYDEGLRAVNKGLARTGVTSYLPTVVSSTPEVYWQVLPSLGSSGESHRAEDGAESLGAHVEGPFISTGRNGVHKTEVLRAATCFEDIIACYGKENLTGPCKSVRMITAAPEVGDMLPNIPSLTSEDIIYSIGHSDATYEQALTATQQGATMITHLFNAMRPFYHRNPGIFGLLGQNECPRPFYGVIADGIHLHPTSIRIAYNAHPDGLILVTDAMKLCGLPDGIYDWTNGERIIKSGARLTLEGSDKIAGSSATLIECVNNFRRWSGASTAEALNAASATPARLLGLQGVKGSLESGADADLLVLDDEEDPFSGPTLTVRQVWKRGVKIYDTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQC0</accession>
    <name>A0A370PQC0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_264286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="312" mass="34051" checksum="95D948D6F886D4EA" modified="2018-11-07" version="1">MPATEAASTGHFPPASDSIPPPKSLSPCSFLSAGGVADSIPCRTHLSRGGHFFSFELEDEGYSYKNLKGQSQALGTILAEAGINSVCQRVWVNSSHGIYNLDYNLELASGSRRLRSDNNINIEITSIGNEIRAGLLRPLGETSSYSNIGALLYSGAWGVKDSNLATLPKIIIHLVDGWSWDRQSYSYKTVLSTSVLLNTDFDYFGILYYPLYSASATIASLKTTLANVQSTYKKPVIVVETDWPVSCPIREYSFPSDLRLNPFSVAGQQQFLEKLAAVVEATIDGLGVYYSEQVWITNARLGSSCDEKPYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQV7</accession>
    <name>A0A370PQV7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_248694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="669"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="846"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1343"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1679"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1959"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1538"/>
            <end position="1579"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
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    </feature>
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        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="174"/>
            <end position="186"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2340" mass="260644" checksum="88DD2AFBEFE00159" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQZ0</accession>
    <name>A0A370PQZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome complex exonuclease Rrp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_274918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0071044">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
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        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
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        <property type="entry name" value="HRDC-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
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    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
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        <property type="entry name" value="HRDC"/>
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        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
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    </feature>
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        <location>
            <begin position="671"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
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        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="782" mass="87224" checksum="D5684161C79A27EF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR49</accession>
    <name>A0A370PR49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="281" mass="30894" checksum="1329E87BBB768982" modified="2018-11-07" version="1">MNPSPAMMPTTLPTMSSESPKRKRASSEESDYCSPSASPTSSGSIPNPQESRIRDAEDWGRYSPRALVAGRLGRLAIRGDQLSTSPVPYGVDQGIVAHTAQSGNWSTSDDDFHEPHALSEANSSMEISPSPEGQSDFAEATQSPDIARTGSPSPRKRRSTPSPRKKKLPTTSSKMRSRSASPPLMTDTAESPLTWHDSEITGHNPTDPTDDGYGLNGIGFKPTAAMAWARSERRKKQVADWRSREAREAREKRRERRDGADFERIRSIQSGAIQKRVKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRF5</accession>
    <name>A0A370PRF5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_263628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="75"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="288" mass="31231" checksum="12066930BFA6F9DF" modified="2018-11-07" version="1">MSWSRLIRFIDTTGEVCFGEPAISDITKLTEECLAGTLFAQEFVGDSPLSVTPGSRRLQVKELLGILRPEDVPIIRCVGLNYMAHIKEGVRTPPPHPSLFIKPSTSIASYNEDISIPRIAQDSVDYEGELTIVIGKPGKNIPKENALEYIAGYVAANDVSCRSWQKDPLKAGGVPQWCFSKGFDKFAPVGPVLVSPKVVGAADNLRLQTLVNGEVRQDTNTNDLLFNVPHLISFLSQGTTLERGTVIMTGTPSGVAMGMTPPKYLKDGDVVEVVVEGLGATRNVMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRL5</accession>
    <name>A0A370PRL5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_325491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRL5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="13834" checksum="10ABF642030146C2" modified="2018-11-07" version="1">MADFQSIAQQFVQFYYQTFDADRQQLAGLYRDNSMLTFETASQMGVAPIMEKLTSLPFQKVQHQISTLDAQPSVNGSIIVMVTGALIVDEEPRPMNYTQTFTLNPEAGSYYVFNDIFRLIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRM6</accession>
    <name>A0A370PRM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_127869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20881" checksum="1A7EF1A37502F100" modified="2018-11-07" version="1">MSATDGQPPFVSTTQTPEEEANIDVAKRYMSLAYSPTHNKGAESVRHLCTPDSWFWSPSTFPGCLTPMDYADSHAQVMASVNDLHIVRYDQEWAKDGHVLLRYTAEGSHAGKPYKGIEKSDPPRKARWSAAAIFEIQDGKIKSFTKDWDQKVMQIQLGWAPVQESDDPRWNRAMLAEPEKARNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS90</accession>
    <name>A0A370PS90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_274350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS90"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="569" mass="61961" checksum="C71CB1A464B9265A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSE2</accession>
    <name>A0A370PSE2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_132457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSE2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016968426" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8786" checksum="90FF169A27D2F6F8" modified="2018-11-07" version="1">MHTSQASLKCTCLPFVIVAVAQSYIGRCCGLLNLTATWPPGYVRIGLPACVSNHVVTSGRFAIYSLVSIRLHPDRALRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTF3</accession>
    <name>A0A370PTF3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016686952" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="6437" checksum="20BD6C091A3A780F" modified="2018-11-07" version="1">MRFFAVIALLASVAVARPAENGALNVQVMCLGRNDGMCVGGNITAAGNSCCPPLVCGSDRLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTS6</accession>
    <name>A0A370PTS6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_290440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370PTS6"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="250"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="654" mass="72361" checksum="626734C634EC1025" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU04</accession>
    <name>A0A370PU04_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_246826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="155"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="65448" checksum="01AA8422D08F2134" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU16</accession>
    <name>A0A370PU16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_281833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="58436" checksum="20E649AB43473174" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU56</accession>
    <name>A0A370PU56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_263325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU56"/>
    <dbReference type="SMR" id="A0A370PU56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="118"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="367" mass="41080" checksum="C0B2A8C927735F4B" modified="2018-11-07" version="1">MSALKDEKTLSELRPRVLIQPLHNSIPSELLPRFDPVYVEHYNKYNAGRLHTHEVPIEDFRKNPAKYAIAYGRAQGPDVFRITEQKCPVQGGEITIRIFEPAPKADEHGKAKKRAAFVNFHGGGWVFGDLSVDHDFCKTLVDGLDGHLVAFDVDYRLAPEHKYPIPVDDCWTAFNWIRSQKAEEFNVDPNRIAVGGCSAGGHLSAVVAHLCRNGGIPLRLQVLNVPVCDLHSGYTPDGEFDRENCPYESYREMEFTAALPVARMAYFHRHFLGVPRPARSEEDWKISPIFAPDFSGLAPALVFTAEMDPLRDEGEAYAAKLKAGGCRVEMMRMAGAPHTFAMLDGILESGRIYTEKVIEAMKRELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUM7</accession>
    <name>A0A370PUM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="112" mass="11887" checksum="80662CC4505780F4" modified="2018-11-07" version="1">MGFLMNDVVADGSGEISEEPANIVTATKLSKTLSHELLMIGKVFSQGTVKTAYDGASLSVSPGLKSSKVWVLACHAQALTVIERPGRSSQRPSTCFSRKAYPGLAQRSSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV35</accession>
    <name>A0A370PV35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_245814</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="64010" checksum="023D4518E32ED96E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVD9</accession>
    <name>A0A370PVD9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVD9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="39340" checksum="856370229BBB6565" modified="2018-11-07" version="1">MGRFTGDTKDPAVNVSTWFLLVTASLSVIFRLGTKYGSFRTLTNDDYLIVVSLIFCIGQSIAVSMAVANGYGYHFSTLTPERFDNMMKSQYAAALLYIPSLYFSKISLSCFIRNLTPTAKDHRVANVVQISVTVMAVICLLGTAFQCSVPRTWNYYTGKCMNLIAWHYFTGIMNIVTDTMITSQALYLIARIQTSWKRKFVFASIFLSRVLVILISIVELILVSQNDATHDPSFSTWGVTISVETIQCLSIVTACWAQLKPFLNMLKSNGLRIQGVDYRSTNNRSKWSTTRSANRTESKYTRSGEHELVGMGAGQGNITTVSAARLSDDDSQSSQAGIIREVRTWVVSEEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW87</accession>
    <name>A0A370PW87_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_273263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW87"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="299"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="964" mass="109340" checksum="E84ED61EBF3AB456" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWP6</accession>
    <name>A0A370PWP6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteinase aspergillopepsin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_273585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629584" evidence="4">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="29993" checksum="8EA7FC6FFBF237E1" modified="2018-11-07" version="1">MKFSTILTGSLFATAALAAPLTEKRRARKEARAAGKRHSNPPYIPGSDKEILKLNGTSNEEYSSNWAGAVLIGDGYTKVTGEFTVPSVSAGSSSSSGYGGGYGYYKNKRQSEEYCASAWVGIDGDTCETAILQTGVDFCYEDGQTSYDAWYEWYPDYAYDFNDITISEGDTIKVTVEATSKSSGSATVENLTTGQSVTHTFSGNVEGDLCETNAEWIVEDFESGDSLVAFADFGSVTFTNAEATSDGSTVGPSDATVMDIEQDGTVLTETSVSGDSVTVTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWW0</accession>
    <name>A0A370PWW0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_101978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="260" mass="28862" checksum="AFA926FF5309AC86" modified="2018-11-07" version="1">MTTHLQQPHHHNFHSHTSSYNPYHPYTIPNHAQTKKQRSRPHRRQRQHHPSTKPPNPSALKTPSSPSPSKSNRCFTWLLLPPASNTHIAKNRSSFSSYRRAPCKIANQRVLGVGTVQLRVQRAPDDPRTNTLVLHDVLHMPNAKCNGISVAKYTGESEEETASEGGSSAGERAVVEEVENGGLVKVKSEREDGEGLWFARGRSRGDQCEGEGGDDGLRVVLAGEKEMENDDGAGRGIMGVVASKEELEMLNERVRNRSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXK5</accession>
    <name>A0A370PXK5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amylase cluster transcriptional regulator AmyR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_208594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXK5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="610" mass="67806" checksum="D4307844FF988D99" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN4</accession>
    <name>A0A370PYN4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_245620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYN4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="622" mass="67884" checksum="0883EC26719EBF7E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ78</accession>
    <name>A0A370PZ78_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_2164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ78"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="68" mass="7433" checksum="54CA43F59F988C09" modified="2018-11-07" version="1">MTKVCVASMQVRCCTSSTCRLSLHHGLWTPNDRAILHHASPGGGGSVVLFDYVNDGAMRFQAKDGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZG8</accession>
    <name>A0A370PZG8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZG8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="286"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="801" mass="89939" checksum="59736FA8D868AC90" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZL1</accession>
    <name>A0A370PZL1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_271895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZL1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylglycerol lysyltransferase C-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="51940" checksum="CE8D5427634C68C0" modified="2018-11-07" version="1">MTSSTPRKQKKSQQSNTKVLLADTIGQSLYERLLQARLDCPVTHWAPVHHPLAPQPSSTINCNLSINSSSTITSSPSTSTSDFKSIPSSRTSHDSFHKPSSSPIHPPLPSNRIITLAGPITTSLPILTTITHLAAKHSQVSHMSLLDPSYTIFLNTTHTAALCFKVVHQTAIIAGDPISSEENIPSLLSEFRTYRKAHLLGMAFLGASPRLTHYAETQTLTGSKSTNNWTMLHFGTSRVLNPTTNALLNESTGKRLLLQNKQLLNPNKGGITLDIYIPGSNTTLENELQDIYTTWRTTRNTSTTPQAFITEYTSPFSSTLLPSLMTYIYAKDKDGVPLAFAALRYCGANNGYHIDPCVALPTAPKGLTDLLMFAAMALCRHAGVSYLSVGFEPLEELGEVRGLRGPLEHLARGAYRFAFKRLPSIQGKKAYHDKWRTEEGLEERLFLVLTGAGGGLGVVAVTHVANVKIRRVVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZM8</accession>
    <name>A0A370PZM8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_331434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZM8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="47810" checksum="011EE91EA83365A2" modified="2018-11-07" version="1">MASIRSLLNPDTSCPSLNPASSQRELSLQSPHSERKKAPKDQPSFRRGKIQGEVRYRVHDERDEELKTIHLKHKLYPLGNIADFPDRIPYTSKKRSFKERTGREGFEVFHYTFEMPDNPKTWVISWDYNVGLVLTRSLFKCNGHPKTTPAKVLKMNPGLSDISHSITGGALVGQGYWMPFRAAKALATTFCWNIRFVLTPMFGLDFPAQCIPPNDPRFNNMIIDPEIIRQAAEDVAYYRSLEPPISRRGSNNSFQEPDRDQQNKTRKSSPCQQKCQSVSPHDIYCVSPTSCSNSTYMLADTPYTADGSTSPRAVFGRGMREEFRSETSSQLTFYGSSLSSNHLSDDDHKRGSQVELQENHYGSDLPSAEVFSATGMVGACSWQPTDTCEPEASLEGSRAAIAAHALMDLRNSGIRYGWTGDDGVMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZN1</accession>
    <name>A0A370PZN1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_261006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="15149" checksum="E6F05A5487BD861F" modified="2018-11-07" version="1">MSVNTTRNRNVLEKLFKEVLNMRDSVPEDGHISIDSFRDVEHVTQFNFNELDSAGVNLALVPPVLFKPMDLADLKQHPVDPELAREFFDIDQDDECDFPMEPVDRVRQVSTLIEDRTTHEARSKQNLQIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q021</accession>
    <name>A0A370Q021_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q021"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="142" mass="15444" checksum="890AAB34C3085922" modified="2018-11-07" version="1">MSEQTFHTTTQDIRKPESHVSQAHDGKTPKNSNVSAMKSIIDQNTDKQAQIDKAQSNLPLPEDPPRASDWNSMDQRTVNVGSGGREGPVSGENNSALREPATASSSVRVSGEEYHTNTQPMSGVGRQGKDNLEGLPRDALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0T0</accession>
    <name>A0A370Q0T0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_9484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0T0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="380" mass="41411" checksum="1FFB4F248CA109AB" modified="2018-11-07" version="1">MDVTNLAVDCPVIETGSLALWMASSEVDQKALGNFAAITGLENPFLSAMLYKILGLSVMLSKKLFRARRLRRLDPTRETKSLHLYYHIIWLSREGLLILEEFVLPLVEGFMELKILAYKLRASFYHIFVLFQNQPAVHSPGIVSLPSNTPLSNGVTEAESPSKDSNSRFSFQLKPDTITVSGKASSASDSAPRGKVTQAPPGFAPVQPPKSNSAFLLPALDYTPTATACFNHAALLADQFLPGSHPLRLSIKLEFAAYLYDCLHDAHACRRLAKQAIADVYNAQEGMDDESFEDAAEIVGILGKMVKRGRNTSSAGNSTTAVKTPREERSEGSRTPSFQTTLKRPARVPKSTSSPARATKPTTSEGMSPAVPDPTMMNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0X0</accession>
    <name>A0A370Q0X0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_244236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1346"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1350"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1071"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK48083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1369" mass="154565" checksum="9690EE5D8F4E1330" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1I0</accession>
    <name>A0A370Q1I0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_323135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1I0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="21518" checksum="7B758E893B0465FB" modified="2018-11-07" version="1">MAGGATKFRHLSRKSSHRQALLRNLVTSLFQHESITTTWAKAKEAQRLAEKLITLGKKNTEASRKRALSTFYTPHELLPKLFGPLRERYAERPGGYTRVLRVEPKKDDQAASAILELVDGPKDMRFALTARTVARQRSQGLETLNELTTMNVNKVTRFRKGGIADLEREIKRLEITGHGKEDAGKAKPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Q8</accession>
    <name>A0A370P4Q8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Q8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="212" mass="23669" checksum="97E694082871A69C" modified="2018-11-07" version="1">MIGAVEVPASGSQEKASSGRDLARTGKLTSWEKEEGFELGGLGQWEDGDLETPRESMREKARSSKDATIRGRTRSLSGCTITQLVDMTDAAIPAEGVGKKYWSCKCTWRIVQGSYSYLDGSPTKETSGSYLSLLLVTPDNFDHKIAIPSEILSMNQTKIKNPHNHQISPHHRLRRQFSDSERTLIECSFLSDIIIINQRHPFMKETHSYPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4W8</accession>
    <name>A0A370P4W8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_108805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4W8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001242">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="40738" checksum="DEAE7DBB4D5D2446" modified="2018-11-07" version="1">MAEGQPQPTAQPQPQQPILQCQKVSDIIRSFRPTKAFRGPKQDTSNYVTSLDFDDQGDYLVASGDDETIQVFDIKEGKSTKSVPSKKYGAHLARFTHHSRQVLHASTKVDDSLRLLDLHNEGYIRYFQGHTDKVTCLALSPGSDSFISCSKDDTVALWDLGSRNAQGKLKLATPYLVAFDPSASVIAIASQSTASVLLYDLRNYDKAPFSSFDLAPYEERYTPSTRGRGWTRLEFSNDGKHLLVGTDYHGHFILDAFEGTVKAFLVGKAGSPGRAAPVSTTGKPLGQGDACFSPDGRYVVGGSGDHSDMLVWDLQQSPPEPNGLLQPMTRLSHRGRTAIVEYNPRYNMIASADKETVFWLPEDPSRSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4X8</accession>
    <name>A0A370P4X8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_340134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="398" mass="45555" checksum="DE5989A80016F861" modified="2018-11-07" version="1">MAELRKVPASQAAQQQQQPIHNDDNVPSLKTLKDAIPEECFDSSVVTSLLYLARDILYCAILTYGAFHIHLLPSLPLRALAWAVYGFFQGCVGTGIWILAHECGHGAFSKHQTFNDIVGWAAHSFLMVPYFSWKITHARHHRYTGHMEKDTVFVPWTDNELAKKKNVRIEQLKHLTEETPIVSFLQLIGHQLFGWQLYLFLNVTAGPKSLPENRPIRGAASHFNPFGDLFTKSQYFSIALTDLGLLIMGSILYYASTQIGAWNVVLLYFVPYLWVHHWLIAITYLQHTHPAVPHYTAESWTYTKGALATIDRSIGFIGRHFFHEIIDYHVVHHLFSRIPFYKAEEATRAIQPLLGVNYHEEKESSFLYSLMTTFRKCIYVSDGKKNGVLHFVLPEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P563</accession>
    <name>A0A370P563_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_339997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P563"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="44426" checksum="249D63FFC3B18354" modified="2018-11-07" version="1">MRLNFSQPPTPALSRQNTTFLNNAHHYRAGTHPHLLTSRSKPRRWPLVFRFIKGAIHAAILLPVFLHAAFTAFVVYLDVYVFDTVGLPSSIIPSLSIVVGLMLVFRNQTSYNRFWDGRNGMNTIYTCIRNLVRTIVTNGYSTAGPPTAAEKEDIERTIRILMSIPFAVKNHLRAEWGAAWALGNDVAENGVAAFNPDYASLLPAGLVGHEDEGLGLPFQLTFFVDGFIKRGVERGWFNAPGASQMQAQLNSLMDAYGKMETIKLTPIPVAHLIHQKQVLALFGCVLPFGMVDDMGWWTVPMVSLVIFTLYGIEGIGSQLEDPFGYDRNDIKMDAIVGDAKTEIDVVLAEWRRLMASLESATDNGDQHLGNGLVVEEEVKEPKFMPPDMFLKHRARPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5G6</accession>
    <name>A0A370P5G6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_310158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052750">
        <property type="entry name" value="GH18_Chitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42976">
        <property type="entry name" value="BIFUNCTIONAL CHITINASE/LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42976:SF1">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016778899" description="chitinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="132"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1740" mass="193514" checksum="F401D9FC0AFA96DC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5W2</accession>
    <name>A0A370P5W2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_241850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5W2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000982">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="573" mass="62302" checksum="22EB2AEB808E6C7E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P608</accession>
    <name>A0A370P608_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_94977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P608"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="672" mass="72729" checksum="498E8882B63FDA41" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P635</accession>
    <name>A0A370P635_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_242043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P635"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000030">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase, carboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="7">
        <location>
            <begin position="115"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="33463" checksum="5CC1879E54268D6A" modified="2018-11-07" version="1">MASQYGDLRHLLPGNYKRLIADWLEEDCPSFDYGGFVVGESEGEARLLGKSEGILAGVPFFDEVFSQLGCSVTWHITETTPIVPITHCATVTGPIRKILLGERVALNILARCSGIATKTSTLVSILRSHNWPGTLAGTRKTTPGFRVVEKYGILVGGADPHRHDLSAMTMLKDNHVWACANNSAAKDGGDKAAVEEGSIVRAIPRAVQAAKAAGGFATKVEVECRSLEEADAAIEAGADVIMLDNFTPEGVRDAARKLKTGWAGKEKAFLIEVSGGLNEANAARYACPDVDILSTSSIHQGTGIVDFSLKVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6M7</accession>
    <name>A0A370P6M7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RNA lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_321718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6M7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="523"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="677"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="719" mass="79746" checksum="8A136897D32946B8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6X1</accession>
    <name>A0A370P6X1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_309068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6X1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="564" mass="65031" checksum="A2C01D9B1D81D1B2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P723</accession>
    <name>A0A370P723_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_297988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P723"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="328" mass="36208" checksum="C607B7B52902BA00" modified="2018-11-07" version="1">MIAPTEPVLSSNSATPITQFHPEITREALEEKVILIVGGANGIGASLVELCCENNAYVCIGDIDSTAGAPLSRKCREKWPVYWDPSGPPKPPRSSFQETDITNYQSVLDLFDFTFKTYKRIDHVVVTAGSMEPKENWFDNALSLQAVREPPSTRDLDVNLTGTLYVVRLAGAYLRHNRGPGVDRSITLFSCAAGFKETPGVSVYQAAKHGVQGLMRSLRPYFIHPYKHNLRINTICPWMTQTHPAVTKKLCDRWEEEGLPISSPLQVAQVAAGVLVDDSLNGTSMYVEGGRAWEIEANLDRLEPQWLGEVPAKTLAQGQKVLKDAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P741</accession>
    <name>A0A370P741_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_241251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P741"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47755" checksum="4621C04DEFAD19F1" modified="2018-11-07" version="1">MAPRLRIEVNQQSRQNPTSPDYEGVNIASRSHVITDGHLDGNVIIFMPGNETANSSQQYLVEVTFEGHLSAAINLNISTQLLRLAKNITLLRASDVRELSQQSTTNTPSRTILHPFHFTIPQTANFVTSDQNASTTTLPPSLSFKPMPVYNSNDLILRGQGRIEYFLKARLFDHGNCIAENEAPVTFAPARECPPPICISDFPGEYTLASSRRVRDRLHRRDLYYLSVQTGEPAPLYLGRSTMVSTVVPLKWNYRCLVPSQQHANVPDIYATIQTSLRATTFVSVSPQDRIPLEEDANKLLDFKLVANTTGTSLTQARKLRIASWGNLDGGGPYGTQQTTTYQAITPLILNFDARDYLPPTFTHPYISRRYSLSISVSVDVDNSRHTSLRLRVPVQVSYEWGECPIECREDESFRLDPGILPPYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P761</accession>
    <name>A0A370P761_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_279530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P761"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="803" mass="89285" checksum="73FFB8E162ACA82B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7F5</accession>
    <name>A0A370P7F5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_339098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7F5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="32570" checksum="16DF93534249958F" modified="2018-11-07" version="1">MSIVSTDTTESNYPPETDSSGTVTSYMPLTSVWTASSGCESKFRLDGPSLMAWDPGYMLDIDTNARCCPPQMVTWWEQALLGVGGQYHTQMEIGPFTGPESWPTVASSIKNEYSTLWMCCPSGYFLSQGTVGQVTGRCMSSVYSGQTLTYGSTPLSDHTAWAIATTTLTTDSTVGAIDIVGWEIKYPVTATATAISTSTSTASTSSSTLTSAPSTAEDNTSTSDNSLSAGAKAGIGIGVGVGAVGIIALILALFLFNQRKRLAINSQQPVAAYAYYPPFARNAKPAELPGFRGMPGDAWASSPVEMGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7U2</accession>
    <name>A0A370P7U2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_308125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7U2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="50071" checksum="A2C8F48F05127A6E" modified="2018-11-07" version="1">MARIDLSELTIARVHTAFHRGDYSAADLVQAYLRRIDQMNPRLNAILAINPNAVQEAQALDDAFRASRTLRPLHGVPVLVKDNISTSAMPTTYGSKVAASRPILPLDDAQVIKQLEGAGAIILGKTTLPDWATDFFSASTVSTWTQNPYDLARDPGGSSSGTAAGIAANLALVGVGTDTGGSIRLPSSFCSLVGMRPTVGLTSLDGVSPFVGCQDTVGPMCRTVTDAARLLDTLVLPTSPQSLAPSGGSYAAHLLPDCLPGPVCLGHLPQLGAEEAAVEALFTQVLTRLRGHASVTVRDLDIPSLSSTLAAASIMLSRGQHDLDDFLRTTVGTSLKTIYRNQAYPPTNFGIPGVATHASTLTDRSTASNARDALDRIITAHLGQAGVEVLVFLTTGRAAPRQEEITPEMGVTFPVHAMLASTLQWPAISVPIGFTATGLPVGLEILGRPLSDQRLLEVAFVIEQIVQGRRPPTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P831</accession>
    <name>A0A370P831_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_297306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P831"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016868517" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="77" mass="8916" checksum="0AC4A2A3097F99A5" modified="2018-11-07" version="1">MRFTLLASMALLGLALAAATEPNTDDVGSTKVTDGTLDVNYCGERCEYDWECRRGNRCHECRKQHHERYGRCRERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8L6</accession>
    <name>A0A370P8L6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_286133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8L6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47967" checksum="460B17A1129CDD54" modified="2018-11-07" version="1">MRDQTGTTDNPARICCQEGRSEVMNGTSTASITSESVSARFLREWNNFNEETFAVGSGLGLTGRFSKHICDAVTKALSVTSLSHLRFGDYQTIRPFESDKIPNLVMLTVPRHKILLGGEIKTFWTVFLEDYPVTSSYATLVNLQRHFSNPKAFSRVVMFMRDHELNYSFLSTYKTTVLIRRTEDFRFEISLPIDEQSVNPCPPEFRPELLRKCSLYFANIYYQASTRPSPFRHQVTIKDNTSGESVGPESIIFRTEGTDVLKIINCKSIIQRTKTRAIFNITWDGKPAIAKCWSEGWYKSYAQETSVYIWCFSLFPKGNILIISKVQGEPLTSQWTTLSPSSKPHIHSEVYKAIKVLRELSLVCIDAGMHNVLYDRVTNAVTMVDFELMQPVEPELVSPDLPEMYAILRNKLVQGQTRDSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9E9</accession>
    <name>A0A370P9E9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_320995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9E9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="299" mass="31893" checksum="8938DF05E61C1C1C" modified="2018-11-07" version="1">MPKIETVAIAGASGTLGPHVFQALVNAGFQVSILTRSNKPGAYASNINVFEVDFNSVESLTTALKGVDAVISTVGGAAVDNQTVLIDAAIAAGVKRFIPSEFGNVTTNPKVEKFPVYSSVFKIRNYLQEKAAAGKLSWTVLACGAFLDLVLNTPTLLDFQNHTVTMLDEGDNRISSTSLPAVGRAIAAILQNFDATENRVMHVSEAILTQNQLIGFAKEIRPDIEWSISKEQSSLLLQESLEEFGAGDFSVPTFMKLLKGTALAGDTYGAAFDVTDNELLGIKELAPADLKKLIAEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9I6</accession>
    <name>A0A370P9I6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_338624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9I6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26281" checksum="02A110080E872567" modified="2018-11-07" version="1">MPGVTEFIFFHLNPAVKPEDPTNNEAGASLLQLFKNTKHQNGYLGSSWGRSTEDENVIVWVIDWKDAQTAPTLIPSLTPYLAPSTPLTTFYATLSPAPPPHQTHDLSSSPVTEIFTPWFPTSMSAEEKKNLHESLVAFRTELVENLEEGKRPQRLIMGQVERPGTRKHGDSPSGEAFGMVVLAGWESVEAHMDIKGTEAFGRGIAPIRGWMLKGDGGDVEKGEGGFGIMRHVRFQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y3</accession>
    <name>A0A370P9Y3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_256045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="693" mass="79039" checksum="DD96018EFEE2BE0E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAH7</accession>
    <name>A0A370PAH7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_320954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016697099" evidence="1">
        <location>
            <begin position="19"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="527" mass="58001" checksum="44727F3EDF0D7ECD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBC2</accession>
    <name>A0A370PBC2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="12096" checksum="81600849898FA67D" modified="2018-11-07" version="1">MYLGRYPDTPMVTLYKDTYYEGDCVRIPADYCLLLSRPVPARYVLSIKVPDGVRCYLMETPKVTVDESGCSFLQLVAWVYGLTVTVMLELRFWLYVSINWITSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBE3</accession>
    <name>A0A370PBE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_49669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="231" mass="25908" checksum="600CF67175FBBD7E" modified="2018-11-07" version="1">MAWFSSVLGKGMICGSEYRHLPIDEDHATDASSRKAFIPWWRTKWALFLATVLSLSIIVVLAFLPSYISRGFQVTNAPSPKYQHCGNSTTVARSRGCQFDLVTYAWLPASCIEQETLAEFRNWLEGSERAFGSWPFFADREGNERIADEQALSERVGVPTHSPQEEHLGHCIFLWRRLARMASTGPVLDIGLGHVHHCTEHLLDRLRGANPLDSERPHSVFEVGLGGCITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBR6</accession>
    <name>A0A370PBR6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_337982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBR6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="61"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="429" mass="46998" checksum="053EF12CE4ED6482" modified="2018-11-07" version="1">MSQFTIHTSSLFDPKLRLFRPNVSVTVDPVSGLIVRVFERDADTPLSEILQPGDIDLSGKYVLPGLVDAHTHIFLHSYDEAGALQQKRDESIGERMVRAVNHCRTALLAGYTSYRDLGSEGMQDFDANIRDAIARGLTPGPRLFVATKVLASTGSFECRTENSAGGHCLPSSADAVDGVEACRQAVRRRIAAGADIIKFFADYRRRIMRYPPAQQHPYIAGVLHPPKEPNPDYMVFSKEEMQTIVAEAKLARCPVSAHCATLEGAMAAIEAGVSTIEHAYHTTDEMFEQMVKKGVILVPTLAIAERLHARRFDQILSGVKRAHEMGVRLACGGDTGTYPHGENVRELELMIQAGVPLSEVLEACTVGGWEACGGDLCGRRFGWFEEGTQADIIALCGNPEEDPGALREVDFVMKDGRVWKIDGLPKGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC29</accession>
    <name>A0A370PC29_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="758"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="984" mass="108295" checksum="40B4A89E103E100F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCN7</accession>
    <name>A0A370PCN7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_46237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="17774" checksum="C76AD5500A822D02" modified="2018-11-07" version="1">MTRRPAWAVRRRAASYFLYGVQIGSSSVGARLLLASGRRIPRGVSGDRCLSDRPSVSQAPRLVMDAGSHHVLPNVLDGRQGPSGWRPTASQLRNSSASRPILLPPSSSLHPIHAHRESFITFSKHLHRFSILSLLLLTVSDYGWCPVLALVDSSCRLLMSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD50</accession>
    <name>A0A370PD50_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_328723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD50"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="448" mass="49548" checksum="D452ED41F22B4E7A" modified="2018-11-07" version="1">MPKSKKAGVSSPAGQQQQQHPKKHRKMASFAKLSTTTTTNPAKPKAAQSAHHQPGSGNAKNSNNDRKMKNSQQQQQQLQKNQRPIVPFGRMDRILLVGEGDFSFARSLVLQHRCKNVMATCYDSKDTLHSKYPKAGNNIHDIQYAFSKATTEELASDSKEISSIGGDAGIVETNAQGFLEDQAQRRGPKVIYSVDARKLGLPAGGGKEIRTGFPRQERRRPAWKEAKSGASSAPQGGPWDVICFNFPHVGGISTDVNRQVRANQELLVAFFKACVPLLSHRPERVDSDDEDDWDNWEGSGVESSGGENHHDSSGDGNQLRTANTTGQATCRNRVEPGQILVSMFEGEPYTLWNIKDLARHAGLQVVTSFRFPWASYKEYSHARTLGDIEGKDGGRGGWRGEDRDARMYVFEVKHEDHPVMRRNAPSSKAGQSARKKRPRDASDSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDE4</accession>
    <name>A0A370PDE4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_277584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="66046" checksum="3807A9077EEC6179" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDN6</accession>
    <name>A0A370PDN6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="165" mass="19164" checksum="5108E8B1503D7246" modified="2018-11-07" version="1">MSLPNTYQPIITTEKDLPIAQKRRTSYIRPFLLFYLNSLIAEIIFLAVGIFIMTGTRDLFYKVIWTLVFCPLGMGGAMGSLTNVFIVDHHYGKKAAHFTGILSLLVFSACNYLCYSLDRHFGWFGASEHPMWFHWRYPMIWFVGYWNGLLLFTDKGQERLARFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE36</accession>
    <name>A0A370PE36_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_328471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="38367" checksum="2F5B6E3E72155293" modified="2018-11-07" version="1">MQGDKVTPISCLCGDVAQEVELKQSANHSALNFCHCTACRTVTGMLCSTYYPLQAGPESLDSLQVYQEADCISRYFCKTCGAHVFAHAKNTGQFFVAAGLLVGRLPPTNSIRHWRAAETRDGGLTPFLSGQPEESAPACWLRTVPSNQASHTEVGLELSSRDSDELLARCHCGGVEFYITRPDSSSTKPTSPWSDLLAPYHSSSSSNPQDVKWWLQDENTKYLAGTCACPSCRLASGFPIQPWAFVPLSNLYNTRKAPLAFGTGTMRQYKSSPGVYREFCSRCGASIFWHDDERPLLIDVSVGLLRAEEGSRASGWLKWATQRVSFAEMAADQALIQQLQNGLKIFGDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEI2</accession>
    <name>A0A370PEI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_35039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="895" mass="99872" checksum="BF60317EC24A76BF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF30</accession>
    <name>A0A370PF30_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_37674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF30"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="142"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="43270" checksum="E0043BB1D91B17DA" modified="2018-11-07" version="1">MAPAPIASSSDDIATVLQLVTPPQIAPHRSHDPSNNQKRSDPFQFGSRYLEEGDDVFEFNAWDHVEPDDEFKAFAEVQYSKQRETPVSDFDRNRFNADPAKWWNLFYKNNTSNFFKNRKWLRQEFPVLADVTQPTAGKKVVLEVGAGAGNTAFPLLENNENEELMVHACDFSKTAVKVMRESPHYNPKHITADVWDVTAEPDENSNGLPPGLTEESVDVVVLIFIFSALAPEQWNQALRNVYRVLKPGGHVLFRDYGRGDLAQVRFKKNRYMGENFYVRGDGTRVYFFDRDELEKMWGQWTPEKGLPTAPATGEETEVKEEQNPTDTKGVFDIEKLGVDYRLIVNRQRKLKMYRCWIQGHFLKRDTTAAVDIPKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF78</accession>
    <name>A0A370PF78_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SNF2 family helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_303585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF78"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="482"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="853"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="911"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133665" checksum="E4D4048FF7551AEA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFF5</accession>
    <name>A0A370PFF5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RGase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_294597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016597583" evidence="11">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="443" mass="47834" checksum="F34E5E730F0AF2A2" modified="2018-11-07" version="1">MLVTSLIALLPAIAAAQVSGTVGPRTSASAKAAEKVCNVLDYGASANSTIDIGPPLKEAFQDCQTGGLVYIPEGDYLLSSWVSLVYGSGWALQLDGIIYRDKNVTDGGNMIFIEHTSDIEIFSNNSAGAIQGYGYLFHEQDEYGPRILRLNNVTDFSVHDLILVDSPAYFLNLVESYNGEVYNMVIRGASMGGLDGIDISGANYWIHDVEVTNGDECVTVKSPSANVRVENVFCNHSGGCAMGSLGTDTNISNIEYENIYTYNSTQMYMIKSNGGNGTVTNCSFRNFIGYSNAYMLDLDTYWGDESDGDGIKYENIGFENWKGTSSNGIQRSPIRILCPDANPCTNITLTAVELWTDTGHYVKQECSSAYGEGECLRQQNGTLTSYSFTTTITSVPITAYSPTTTMPGLISTSMDTTTSIPIPTIPTSFFPGASAYSTLMANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFF9</accession>
    <name>A0A370PFF9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_294593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="40818" checksum="1E399D2ACDD49ABF" modified="2018-11-07" version="1">MEQRQELCDSLKGQYAVLPNLYSLFPDWSPELHPEYTRARDESTNPWIKRFAKNPLVCRKLQEADFTTFAAVMCAKSSFEQLCTVAKWFTWYEYFIWDDLFDCGSLSHDSNTIKRYKHTSIEYFKHVLCHEAAYPDLSEFSEELQNALRCWDEIAEHVLTRKVLLAAMIDYLSSVDGVDSIYSEGEIPSVQQYWRRRDRTAGVHPGIATIPFIYDFDISARDMDDTHMKLLRRHTSYLVHIQNDMFSLRKEVRVGQVENLVPIIMLNENLRASQAMKVAFMFAQESARGFDEVVDDMRQTAKGRRRAVADIFIKGCRNIVMGLTHWSYTGERYFRAGEADENHTIYFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGW4</accession>
    <name>A0A370PGW4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30676" checksum="F050B6A007E0E303" modified="2018-11-07" version="1">MGCLQIFLPGIGSCVAFLLGIFSLFAGSQRQFLPQADLLTLHTGGAGGQGAPDYFSIYTMSYCTGYQEIYVSDETTNATTTKTEIVDCSDRSVLFTFNPGEAIAKALGTPSGSLSPDSWPSWITDDFEALAPTNTTMVLLLILGTATSAIAIGIRIWTVVCARASESSRPPMYPGSSASSFDFDIPPSSIEFFAFLVSLLSFAIASIIASVITTEFVKLINKSGNGYGVSATTGTSFMGMVWTAAVLQALTTANSLAAILRYRAQHCRCDWDEQAPPESAEQKPLVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH48</accession>
    <name>A0A370PH48_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="56573" checksum="DE0273AFA5B0C605" modified="2018-11-07" version="1">MVAVEDEEMPSTPCSDCSNVSVVDWDGPKDPQNPFNWPTSRKWLMTITALITTFVALMNGTIITVAHEAINDEFNVSDATFPNSYWPVASWTMGGVFFCLLILPLMEDFGTRITFLLTNFIFLIFIIPQAVAQNFATLIIVRFFAGGCVAVLGNGSASIIGNLFETEMARTKPVALWIVAYLGGSSAGPLIGAPIFAHLSWRWLSYLQLIWVGALLLVNIVILKETRGSVILKRRARKLRDKGENAYTQHELQAEPLRQVLLTSIRRPFKLLFTEYVVFFSTLWSAFTVGTLYLFTQSVEQVFVGLYNWTPVQAGYVQAAVFIGEVCGWFFSLISARLYFNSSKRNKEIPGKPIPEARLYLSVGGGIFGIAGGMFVYAWTSYPSMPWIAPAVGLWMVGMGSVVVVSGIADYVVDAYCKYAGSAMACFVVGENTVSAFLPLATSSMYNTLGFQWASTLLAFISLLLTLAPLSFIVWGKSIRERSPFMAEAMLDKRADLMREPSNGPAREIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH95</accession>
    <name>A0A370PH95_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_252934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH95"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="338" mass="37004" checksum="43AD38850013CB37" modified="2018-11-07" version="1">MGSLAKKVLLTGGTGFIASHILTELLDAGYQVVVTVRTHDKGRQLLESLSNTGDKTASYVVVEDIAKDGAYDEAIQSISDLDLVVHTASPYHFNYTDPKTDFLDPAIKGTAGLLASIKAYAPTVKRVVLTSSSATIVTPPNHPEVYDETSYGSVTWEEAMVPQVTYRASKIFAERAAFDFIEKDKPNFDLVTINPPLVFGPKPRHVTDLKTLNTSNHIIRDTMLGKWKDGGAPIAIPFTWVDVRDVAFAHRQALELPEVSGQRFFTVAGHFSNKRIAEAIRATHPELADRLPPSDVPDDLPEGIYGFDNSKSRKVLGMTFRDLNTCVGDAVTSMLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHY4</accession>
    <name>A0A370PHY4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_276517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="228" mass="24326" checksum="DC3707B1AA27939F" modified="2018-11-07" version="1">MFSVRVARAGLRATAQQFSVPRTAAVNGLRTYATPAQDVKPPVSLFGVDGTYATALYTASAKSANLDQTSKALASLGQTLKADRKLITILSAPTLTVADKQQIVQELQKVAGADKGDILKNFLNTLAENNRLGLLEGICEKFSTLMGAHRGEIELNITSAQELDTKTVNRLEKAVSKSEFSQGKKLKVVTKVDPELVGGLVVEIGDRTIDLSVSSKIAKLNKALTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIE3</accession>
    <name>A0A370PIE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear protein export protein Yrb2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_293937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="353"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="52285" checksum="2B8C0C1722BA36BE" modified="2018-11-07" version="1">MAADPERNGGVEVDETKKEVLERQAADDSQASDNDGGERPVRHKLKETSITSAPKTSTDGDANMTGSAQEGSSSRASSRGRKRSFDEDEPEKNEDDAGHRRKRSRDSNSEEENANADVDVEVPSQPQKGEEVTRDIAVPKKKRSRDQLDKDESTVGASGEKADQNAAEEASTEKSEVEGQPEKKRHTDDAREKESAPITSAFANTSSVSPFGSIGAKAKEEEASKPAAATSSSAFAASSLAAFASSEQSPFGSLGSSTPSVFKSPASTDSPQPAATGFASAAGTSGFAALGSGFSGFSGGFAAAKPAGGLTSFASPSAPSVLGGSKTSAFGAPEEEEEKEDDEEQAGDSGPGEFEQDKTDERFYERPIETGEENEKTYFSCKAKLFHFTNKEWRERGIGTFKVNVRVTDGVEDKKAARMIMRADGVLRVMLNTPIFKGMTVGDGQGKEPKSKQINLASLENGRSVPILLRTGSEDLAKELYRVVRELQDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIY4</accession>
    <name>A0A370PIY4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_319566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="58944" checksum="99C8F0C29A6E148A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ47</accession>
    <name>A0A370PJ47_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_300257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="39933" checksum="398BCDC9082B2CFC" modified="2018-11-07" version="1">MSSNPAPTALTQLPLGEDACPHYSNVELRDYFERLKLPQKYLDSPVLKDATQARTKEHGLPLLQALTRHHTCNVPLENLALHYSTHKTVTLDVAELYTKIVRRRLGGRCMENNTFFGTVLRSLGYEVRNCGGRVARAMLPYPEVRRNQGNTYEGWTHMLNLVRLDDEWYVVDVGMGSKGPNLPYPLRDGFQTTSIAPRLIRVQLRPIPETYARLSTNSTGPPMMWCFDVCYNPADDAKKEWLPVYCFTETEFLPQDYEVMSWFTSTNPRSWFTRYVTSTKMLMDEDKEVIVGNITLFQGTVRETIGANSKVIKECKTEDERLQALAEIFDLHLTDEEKKAIPNERKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJM9</accession>
    <name>A0A370PJM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_300621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="495" mass="56124" checksum="A55A94CDE5454363" modified="2018-11-07" version="1">MSSYHYVRIPHCALCGQRFDKISSFCSVIIRDSPDRDILVTRSLTFHGDTHTIYLEDLGVHIHDYRRKKARHAPSVHSLCMTAGMDLPSPHIIHNLGLAMVPLIMTGLPQEIYRISALSEAVDSLLRDSHDMEVESMLSKLLRRFRDLPLELTMIIWDFLASGPVRCLLALNSSKNIWSDAPLSAGSATISLSGEIVVYFTHLTKENYVCGIRQGHILYGHGSSSFTKIQIPTSNAMFVFSQGIYGLQKLEFLTETGTSPTSETDPDGRRFISVIPYQRELPVRVDIEWDVLKISLISPHNKSVFGHDFIWVPPVPCSHLRWLSPKRFYDWPRHFDFAIQPQRFMTYVPLKRDKRLYGITAFCSSEGFVGLGTHFCSYSYPDFRKQDASVYWYGKQQGYPIHIQLDYSDNISSVHVYWHQSDALSGSYLAVKTIRNRIFVLGPQFPPSKTAMKNIFDSDDGEILGLYYDASPGITKFTSLGTDYSFVTMTAGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJW2</accession>
    <name>A0A370PJW2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="391" mass="41652" checksum="54EA072E7BAAE788" modified="2018-11-07" version="1">MEALIQARQERYGSSSVPLYGTTTSDSSTTAPTSPTLTTPGSSTSLSSQTTSASVVNSSSSSTPTSTASSLPSHNNGVSKGALAGAIVGSIAGTAILVIIGAALFFRSRRKSTPQSSSSGDSDPDGVELVKPRARVQALSSSTPIPPTGGHNSQLDLIPFIPQPADDQTVSTRIQTLFDHIGLHVDNYYVPARYESISPTPEEAFRIESYTSSLVTGSLTTALASRRARRPVLNHVLARNILQAIQPGGSLYPPFMESHGVEPGSAANSTGAMFAWRMLTTRLHAQYLDTTSEAAQKNIATLTEGFSEVFGLYRNPDLPDADRRRHLVSVVKEAAQLSVWLFTQPCSFEFSWSAPSPGSIVILPAVMKISDERGDRLPVPQKMVEETMAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK18</accession>
    <name>A0A370PK18_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_17231</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="173"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="271"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="547" mass="58546" checksum="A822C1EC6F0AD56F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKZ0</accession>
    <name>A0A370PKZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_283461</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0418">Kinase</keyword>
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    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
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        <location>
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    <feature type="repeat" description="Solcar" evidence="11">
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
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        </location>
    </feature>
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    </feature>
    <feature type="repeat" description="WD" evidence="10">
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    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
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            <end position="1373"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="compositionally biased region" description="Basic residues" evidence="13">
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK42861.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2150" mass="233908" checksum="64A13D55730E0E4C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLB5</accession>
    <name>A0A370PLB5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_251033</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLB5"/>
    <dbReference type="SMR" id="A0A370PLB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="124" mass="13448" checksum="25DDF81A7E3631BB" modified="2018-11-07" version="1">MAPKNKGGDKKGKDGGDSNSKGGGKGLKPANAINVRHILCEKFSKKEEALEKLRNGAKFDEVAREFSEDKARQGGSLGWKTRGSLDATFEKAAYDLEPSTTGNPKYVDVKTGFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLF4</accession>
    <name>A0A370PLF4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_276112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="372"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="49923" checksum="37C93554518B94E8" modified="2018-11-07" version="1">MRAAAPPQDLRLRQKITPSPPYLPGPELKLAIFHDLKHALPLSSSPFIASCPGRQSMSQLLSHISLSSLGETCASYLDHVTTNLPPSLHSLHHQLLATLSSAKDSTPLRLLTPLPDLLADHTDGAYTTPVAYTLLVCTIVVLVMSWRSPFANFWRRGYTNVDNTPQVTDNDYSYITQDDIVDPPANTYRNQYAGAEDTEPDTLILKHRKEKYDLHFPAYAINDGALSVGQLRQRAAEATRTPDPKRIKLLYKGKLLDNDSLPCRSEGLKQQSEVLCVVSGVEPGESSPSELSEAEADRNADSARQEGSGRKKSGKNKKRNGKNKKKGGKQADGSNTLPPPPAAAAEPPRPSNGTGMPPPAPNLKLFSNPLDQVNALSSYLQRELVPLCEEYITNTPADAKSREFEYKKLTETILAQVLLNADNINPDGVQEIRDARRALVKSAQNALNSLDQVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLG9</accession>
    <name>A0A370PLG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_166365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="461" mass="50429" checksum="B3D8FDB14E7EC36B" modified="2018-11-07" version="1">MPPPTLTPVKRIQNVRLPGRDSTWEIAISRPHDTPHSIITSITPHPNAQSDQTAPLALPALTHPHIHLDKAFIHNSPEYANLLPSTGSFAEALSFTTTAKQQFTWEDLLRRGEWLIAGSVSAGVTAMRAFVEVDHTVNLTCLEAGIALKDEWKEACAVQIVSFAQDPIFSGEHGDHNRQLMEDAVRRPQVDVIGTTPYVESSVDASKQNITWAIERALECRKHVDFHLDYNLDTGKEALVWFVLRTLKEKGWTSQSTDKRVMLGHCTRLTLFSDEEWALLAQEIRGNDLPVSFVGLPTSDMYMAAPPSSKSHDRPRGTLQVLEMINKHSLDTVIGINNVGNAFTPWGSEDPLSLACLGVGIYQAGTKANAELLYECVSTRARAAIGLSPPEASLSLNQGSRADILLFYDVDDTGSNVSKPRHGVAGIVWDPPAKASRELVVGGQLKASPCSLCPKSAFCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLJ3</accession>
    <name>A0A370PLJ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_335763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2056"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2099"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2125"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2100"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2229"/>
            <end position="2240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2280" mass="251956" checksum="721357E53213E1BB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN5</accession>
    <name>A0A370PLN5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_326809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="45140" checksum="2D589D350480CD45" modified="2018-11-07" version="1">MTETLRPAFADRPRPLLSYGIPFSSSAAHHITDLFHASKIYILCSASLARDTDALDRLTRALGPDKIAGTRIGMQSHTLWSEVLEVVRDAQAVEADLLITLGGGSLTDAAKVVALAISNNTTTPSTLLTLTSEPPTPNPPIKPPSIPIISIPTSLSAGEYSSFAGATHDTSRRKYSFGAPIRGPQLVILDPELTATTPERIWLGTGIRAVDHCVETYLSSGVGSKDGVTEETDRLALHALGLLVPGLVKCRLNNKDGIDADGDGGKAARLDCALGSVDAMAACSAGLPLGASHGIGHQLGPFGVPHGETSCILLPAVCKYNAKHSSSSSSNSDVFPRQTKLRDFLLRQEGVAGVVRKYYADAAVDLGDVLDAVIRELGLPRSLQAVGVGRDQFDALAEHSLHDRWCQANVVPLQEKGQVLEILETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM32</accession>
    <name>A0A370PM32_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="13281" checksum="33F67F8121E26F36" modified="2018-11-07" version="1">MGQRHNRRRTRPRSRNRSANPLLLPSQPFPRPVNLCAPAVSSAFDCPEIPAPTWHYGHLLGQKRDRALRMEASTLEAEQYRLFGGVPGDDVGLCYRMLEYFGGLDYIDCPQSLNALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMH4</accession>
    <name>A0A370PMH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_250109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="435" mass="51615" checksum="F5F991993DC92447" modified="2018-11-07" version="1">MTVPTLEGIPVELRISILFTIPDPGSLWSLLRASPTYYDAFELVKKELLRSLLQKHHAGLVDMTDAIAAIRSRGLYASEQSNKEKIIALLDARNYNQKFPRPDTLPVQLLDEPANTQETVQLLHLHNQAIFFLEDFCKTIRRPVWVDETRWEREIIPLALTETEQRRIIRAFYRLQIYGNIFGSIERTVDAEHTSEDNDWQEKQDVFSGGEMWRLFFGHMAPWEVEEFSCLWEHCCYRYESILREVSDSLVQTGCMFFDELPEDQRPPPGCWYTDCDDFEDPMDKRESLASKGPALLCKVLREEESLARRDLVLVNVRSFRLYFYDFGIWPRPTDTDEMELFYPADKFNFGTDRNGLREFLKTLPPFERPNLAWERIWLRDDLNFAQLFYDMYEFGATNKHRPWQYALWDDERLIEWKVPILSDDYPFWNPTHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PML3</accession>
    <name>A0A370PML3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_156773</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PML3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000162">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="25" id="KW-0430">Lectin</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016909998" description="Crh-like protein" evidence="23">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="34"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK43419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="38327" checksum="734EA1194150696A" modified="2018-11-07" version="1">MYFSKTAVALAAVLPLATAQTYTDCDPLNKTCPADTALSSTTFTTDFTTGSFSGWIATANNVTFTDEGANFVISEKGEAPTIETDFYFFFGKAEVVMKAASGTGICSSVVLESDDLDEIDWEALGGDTTQIETNYFGKGDTSSYDRATWATVSTPQETFHTYTVEWTESATTWSIDGTVVRTLAYSDAQSGTRYPQTPMRLKLGIWAAGDSSEPEGTIEWAGGETDYSDGPFTMTVKSVSITNYNPGSSYTYSDKTGDYTSIVVNNGTSSSSVSSTTGSTSSSTSSSGSTSSSGSSTSSGSSTSASSAAAAGSSSALIGSGSSTSSGSSAAGSGAASASGSASASSSASASASPVYTGAATQVGASTSVLFAGLLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMN0</accession>
    <name>A0A370PMN0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_335247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMN0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="519" mass="57579" checksum="0A574BB13593D150" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMP3</accession>
    <name>A0A370PMP3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_275655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMP3"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39239" checksum="1C2713D5AC1148D4" modified="2018-11-07" version="1">MPLSKLQGVKLPASADFHVHLRDGDMMELVTPTIRQGGVNTVFVMPNLVPPVTTVDRALEYKQRLQAIEPNVNYLMSLYLHETVTPETIIDAKKRGITGVKSYPAGVTTNSSSGVIDYTQFYPVFAEMERQDMILNLHGEVPSTGDVTVLTAEERFLPTLLELHERFPKLRIILEHCTTAAAVEAVKKCGPTVAGTITAHHLSIIIDSWAGDPFCFCKPVAKTPADRDALLRAAASGNPKFFFGSDSAPHPAVSKRGGDKIAAGVFTQPHTTQLVIDAFEQACENGVLKEEDITPEIVEGFMSKFGRNFYGIGEEQKEFIIIDKKDAKIPNILKSDKVDVVPFRRDQQTWSVSWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMZ5</accession>
    <name>A0A370PMZ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="35378" checksum="D5C7660EFB24E22D" modified="2018-11-07" version="1">MTSDKDIDPLDLPICTTCGTQFSTPTPPTPCPICDDPRQYLPPSGQDYTTLRALRAPTHEPPLKNILAPLNNTNTNTKIYTLHTTPKHCIGQRAFLLLTPHGNILWDCIPYLDDDTITQINALGGISAIIISHPHYYATHLVWAEVFNCPVYLSVEDREWVMRLSPQDSSVQGGGSGGGKQIFWEGKEVEVLPGSGVIGVKTGGHFPGSSVLWWKDEGVMFLADTIGTIPSGVGDYGSRGRREGTASYTFMWSYPNMIPLPPDEVHGIWKAIKHTEFDRAYGAFMGMDTVGNCKKRVLDSAKIFVRAMGYLDHAIHEEDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNC6</accession>
    <name>A0A370PNC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_248956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="326" mass="36716" checksum="70A074FB4F4B28C5" modified="2018-11-07" version="1">MKIVLLGSTGQIGQSILRALLTKTSHQVVQLIAPQSESTASSINRQFTAEQQGRLTTESVDLLSCSADDLVPYLANVEIIISALNGKALQAQSKLQDAGAKAGVRRFYPSEYGMHHVYRPPGDEVGYLHPMWTTKSAANEACLHHPAIKSGSMTYTLIGCGDFYNQSREETWCPWTNPKASEYTLHILGDADATIDFTHIDDLGDFIVETIKHPERSENRTLNFVSDRISYNEIARLLEKYSRKEVKKTVYPMSLMDDVWKDKEKVPAEVRGKGAFPDDFWILVKGMQGAGRFWRPPGEVHNGEFEMEGRTFEWYLRGLYGGEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNQ5</accession>
    <name>A0A370PNQ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_282763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620972" evidence="3">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="58871" checksum="FAB9C087F18F86A9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPE4</accession>
    <name>A0A370PPE4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_282748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPE4"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="675" mass="76851" checksum="8343A51EEFA3D31A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQH9</accession>
    <name>A0A370PQH9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_139793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="96" mass="10653" checksum="D5B4C3E0E8AE12E6" modified="2018-11-07" version="1">MFRSSALPMWSRDLLLSPTVSGQFLPLSLTWLEKAKLSPNMPVSMSIFWPQGIPRVPIFVPDEGEALLVLVQWLSTGEKEACLRHALLSSTAPGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQV9</accession>
    <name>A0A370PQV9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_313399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQV9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="241" mass="27166" checksum="3E4F4846A9094535" modified="2018-11-07" version="1">MARHSYKRRASIPEFQNVAIRPTTTKLTITIIILQQPINHSSRANMVSSSSSSMPSTRTITTPSPIDDEDVEVVYTPSTSSTSSSSSPSSIRLTAAGKCKAELKSGNIRLELEEPPTPRHTTLTKLMNLMDLYPLLYVRGIPDSGKGTVNQFRRDNFMLMTREQEAHSFFLPVDKPLEEFDSEEDLLKQVVNSFNRLCKEPRFFFLVLYFLTLSAFMGVRFLELVVLPYLPAPGKGMRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR03</accession>
    <name>A0A370PR03_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_248761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR03"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK44610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="229" mass="25912" checksum="771B357AF28AD59A" modified="2018-11-07" version="1">MTSNPPTTDTTTPTSTNNTTTPLRYIRYNAAHEDTYVPAMRQLISKDLSEPYSIYVYRYFLYQWGDLCFMAMDDNNSELQSSSPMVGVVVSKLEPHRGGPLRGYIAMLAVREEYRGQGIATKLARMAIDAMVERGADEIVLETETTNTAAIKLYERLGFLRSKCLHRYYLNGNSAYRLVLYLKEGVGSMRTNMDPYAQQTGPPYPLIEDRTDTVVTAPEPALLHENGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR27</accession>
    <name>A0A370PR27_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR27"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="610" mass="69139" checksum="F2B302F6EAF73E27" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR44</accession>
    <name>A0A370PR44_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate-binding module family 18 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_334546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703471" description="Carbohydrate-binding module family 18 protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="649"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="701"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="77246" checksum="144F7EDB38DC78D0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRV5</accession>
    <name>A0A370PRV5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016928081" evidence="1">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11233" checksum="7003112F0B9BD1EB" modified="2018-11-07" version="1">MMLMLMLMLLLLLLLLLMMMKQIIPTGLTEDSIPGPNRDQSGNMTGGFATELIWEFLAVPPQSAAVLAEGGSFATDPIKGPDRQLTFAITAEENDCQETGKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRV7</accession>
    <name>A0A370PRV7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="85"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="35412" checksum="6CFB9CB0B172497E" modified="2018-11-07" version="1" fragment="single">MATPAQCYYCFETLAASYRRREPISLASVEELWEQHEQYKKLAALDEDDDSQFVDEDENTAPLSGKSSRSQKIKVPRVSRLQSGSSSSTTQSLASTNSSQSVLSSSTTVTTPSSSDTASGKPREDKYPLFVTWNTVSKHGHKSLRGCIGTFEAQELAEGLKSYALTSAFDDTRFSPIPESLLPSLSCSLTLLGSFEPCTNALDWILGVHGLRISFIHRGRRYGATYLPDVAVEQGWTKEETVNSLMHKAGWDGPSESVARRFLRGSSNAGHGTAGATKPWEQVSDFRAVKYQGLKASSSYAEWQEWRQWVLSLDDGSQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS72</accession>
    <name>A0A370PS72_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3128 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25052" checksum="44603ACB46888FA7" modified="2018-11-07" version="1">MGWWWSSAPKEGQSSAPAASSPPASQPPPETTSAPSQPPQPRTLTREEQADAEWKKLIASLESDISGQKQQQQQTPSAGNSTSSDSTSSPSSADPQAPPSSIAPESLYDDTMSCRSAFDYAFFCQSFGGQFVNVYRYGELRSCSEHWDNFWMCMKTRTLPDQQRRKAIRDHNRKKAIKYKTGPSSEDVWDVRTEPVQNAFSGDFAALEREMQAEEEEAARQKAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS78</accession>
    <name>A0A370PS78_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_131712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS78"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="987" mass="108027" checksum="49A5910323900B9A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSJ9</accession>
    <name>A0A370PSJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_210806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="633" mass="70674" checksum="6C7FB4FED096EE66" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSP5</accession>
    <name>A0A370PSP5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_263958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="12015" checksum="64A1DF238A9E8406" modified="2018-11-07" version="1">MELRYLFPPPPRIPVISQSGQSRHGGPLLELDEVACGLLGGYEIRFHMRYMRQKSDWLGLALEDGGSPYYKRGRGDRSAIDSESLLGWTVVTPLLNVALIIKLKSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT13</accession>
    <name>A0A370PT13_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_135128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT13"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="51"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="395"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="88"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="54881" checksum="79DC2BE59658B8B1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTE0</accession>
    <name>A0A370PTE0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_263095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTE0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="62"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="340"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="455" mass="49591" checksum="5B18DC1C421322C6" modified="2018-11-07" version="1">MSATTTDIAPGDRYRSDGLSGTVPTNNLAESWPSVKNTISMAATSGTGSVPAPSAMQQTEDVSIAQRMVSATIGSFLTNILVTPLDVVRVRLQSQSLVKNTSPFNSHTLQTLKNAPPNLGVTACCREVFWIGQNSQICMVGPEAGALGATSVADCAVEETQRKTFTSTLDGLRKIARNEGVLTLWRGLSPTLMMSIPGNIIYFAGYDWLRTDDRSLIKRWFPDAYAPFVAGSVARTTAASLISPIEMFRTRLQATPGTGAGHFKATLEGLYHMAQTQGYSSLWRGLTLTMWRDVPFSGLYWWCYEEVKKYLVETRKRSYLHGLPHGSSASQHHLHDLDTPTFFDSFFAGASSGSLAAFVTTPFDVGKTRQQVFRHMGDVPGSAGNVPGGVLHPEQLPLPKFLLHIFREEGMAGLFRGCVARCLKVAPACAIMISTYEFGKKMARGVNERSRSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUG4</accession>
    <name>A0A370PUG4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_123458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="142" mass="15899" checksum="6750C33A9E80F216" modified="2018-11-07" version="1">MAPLRILCSTRIEFDPRPSLSKDRYHLGANILSPGLLRFQPARQIRQGDKQYCRMPLLLADPSVKVFISQLSPMIRLVRGCRSDKPWTASNCLGILSVLLIAVAASKGRGIFQSHCQCYGVIDKVREKQKIKKQSGCDVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV5</accession>
    <name>A0A370PUV5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_289505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="535" mass="56154" checksum="E1C7FFE5E3E93283" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVP6</accession>
    <name>A0A370PVP6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_99767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000014">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="279"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="975"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110828" checksum="B11E504E0A537041" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVY0</accession>
    <name>A0A370PVY0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_262645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVY0"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="52727" checksum="705C2F521043D1EF" modified="2018-11-07" version="1">MGGIPFDQPDAIRAGDEKSRAFIHKSSEAIEEGELKLVRRPQSTSGKIPDRQLTRVEPGFPRLNNNAEVRSQLLASFVGGFLPSSRHLQDGKDTNILKTLPELCGNSPLLDRALLSLSSAFLAKQHKDDRLLGYSTKLYNNSMEIMHGKIKSGKGLGQDVLYTTVVFQLYEVSVTILIASRFFSAAGLTLHKLCDAVGRRKAATLYEVLTTQERLSQGSTELEPIDELMDLLAECSALIEQVDTFIEQLPASPDGDKNNGEKLLGSCLSLEERLHQTCLKMQEKLGAPSTLTHDVPLREDLRAHLATSLFPDPFQFVSLACAESHLIYWATLIILYPLVDELLDVLGYRRNDVTPSQSCAIHPQAIEQRPLGVDVATDFTALAEHYADEVCRSVMYCTQSDMNTLGAQHLLAPFSQCAQFFQVHELAQKYRWCQGVFVLLDSLGLGIAPLLKDMVWPQYRSARLRRSLSSVGKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVY2</accession>
    <name>A0A370PVY2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="220" mass="24754" checksum="7C09DFB42AD3037C" modified="2018-11-07" version="1">MAPDRSNISFTITHMNANHQDSLAAYLQVYCHVSAREAKSARLEDISLSDLVISANGTRYTVPIDPAMGSFSESRSRLVAMHQECLARLGRSDITIKEYRRPEGIEIFLFFVFATALVAFSRRSNFLPGSLFYETVGLGAVPPLAQLFYKTQPFVLTVMAGSHVVEASLFTVKRLKRHGVPVLSLVWCAWVVSNLIEGYTVWRRFDRVVRQEGAKREHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW20</accession>
    <name>A0A370PW20_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_324089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW20"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="30955" checksum="88D2FE77B72A4885" modified="2018-11-07" version="1">MAPAKPNKVSRITVACNSCRFRKQKCSGNKPICTQCDQHNRPCDWPEQLKRGPAKGYIEALEHRLHETESLLLNLLAQIPDSQLSASVQGRQDRSSRHRNSGSPPQTYSSSPSRLGKRGTDYWKKFPLHTVQDIRDWQNDCLSNEGDGSTRHSLGPEAVKRPSASQSEYQPETVSPKDQMPEFQGYREMPTLPRIHQIEIPNSPIDAGSSPAKVAYGSGFDGEARENRPRMDPVFEAIQYQRARAEAVHEFPSMQKPSLWRGAPSVSFQQQFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW24</accession>
    <name>A0A370PW24_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_102030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="167" mass="18664" checksum="78C96FF968CFED75" modified="2018-11-07" version="1">MQIFVKTLTGKTITLDVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKPVFPPVPLTAARRSVATPTSSAPRRSSNRRLSYHGFSALLGKRAAGVTIRLQRGRFSTWRWNDESLLIAEVKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWE3</accession>
    <name>A0A370PWE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_103668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="224" mass="26252" checksum="B6A7D70AB40695B0" modified="2018-11-07" version="1">MHKVQEPILHHSLHCIRNGIYSDVEIKCHSSTFKVHRCIICPQSEFFEKALCGEFQEAKTSVITIHDDPTIIKKMIDYFYCGDYDDSPDKSHLATNPDYESPTTKAHVNIEMYMVADKYAIEPLMVLAKNKLEYRLTLVWDNKEFIHIIEKVYGEGSPQNSKLRETIAKFAVEHLATLIELPRFDEVRKEFPQFSYDFSTSMIQRMARVETKLRYVIRKLAQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWH4</accession>
    <name>A0A370PWH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_273567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="253" mass="27689" checksum="22190CA15050CFEB" modified="2018-11-07" version="1">MSSKTIIVTGASRGIGLAITKYLLTAPQSHNVVVIARSREPLEKLKEQYSKQVEVLNGDLADFSIGQKAVDLALKSFGRLDGMVLNHGMLGQVGKVKDADFEQWKHGFDVNFISLVAFVKAGLPALRESKGKIIFTSSGAAVTAYRGWALYGATKAAMNHLALSLGEEEPEVTTISIRPGMVDTEMQRELREDHATTLEPQMHAKFTTVHKDGKLLKPEQPGHVMAKLVLDAPNELTGKFFTWNDKALEAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWS8</accession>
    <name>A0A370PWS8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="474" mass="52436" checksum="32FC38942973E8D2" modified="2018-11-07" version="1">MASVVYTINVECFDDCDSQKNNLRCISQQDTNELIIACDSIVSIVPQKKDGDSLYRLLYFRDGEDTSDLKSKHTLLESIQLATLPTQLRKHLFTQLPSYLRSSGPEGVRIDVIVSTTSGTGTGMSFYSNILQPLLFYIGVTNYELHETKSTRTITELCYERFIPRAKQRLPQTIILLSGDGGLTDMIDAFHSTPESLLVPPTIALIPTGTGNAMANSIGLLAHPTAGLVALLQGTPTSVPTFVAEFSPGASYIIDEGRERIPITRNSANVHGHPKVYGGVVASWGLHAALVADSDTVQYRKFGADRFKLAAKELLYPSDSTEPHKFSGIVTLFKLDDQGRSKREETLACTEHMYVLASLVSSLEKDFMISPHSRPLDGRLWMVHFEPMSASRVMQVMASAYQAGQHVADESVSYGEIEGFRIEFREVDERWRRVCIDGKIIAVEHGGWVEVHKASRALLEILQHQKASPGCIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX18</accession>
    <name>A0A370PX18_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_207873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX18"/>
    <dbReference type="SMR" id="A0A370PX18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="303" mass="33246" checksum="4925CA02B4414128" modified="2018-11-07" version="1">MTRTPAAPEKHNRDSASRYKSGSKISTLFAEELVERSAIAGFGRKDLVVFDNACGTGAISSALHRALGDEKTRTWKLTCGDVSEAMVEVSKQKMIEEGWQNAEVEVVDAQNTGLLSDHYTHVFSAFGKMLGTQGNGIMLTSISAFNLFPDDKAAMEECFRVLQSGGTLAVSTWCSTVWATLIQSAIASIPGDLPTPTTEDIFGLYNKNWADESRVRAQFQQAGFTDINVTSVKKEYTVPVQELAEACKISLPHITRKFWTQEQRDSYEAEVPKAVLRILEEEQRGIGLGAMKAEAIIATARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXA5</accession>
    <name>A0A370PXA5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_64349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXA5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016679367" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8330" checksum="72FDCFB8919B3996" modified="2018-11-07" version="1">MKVSSVLFTVLFSAFAVAAPDGILGTGLGDKLGDKLGDNLHVRSNTDASLPCHGDHAIKCYTTCLISGDPVHCARHCGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXS8</accession>
    <name>A0A370PXS8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_332276</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="12"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXS8"/>
    <dbReference type="SMR" id="A0A370PXS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="18">
        <location>
            <begin position="297"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="43430" checksum="E074CE18C96880F3" modified="2018-11-07" version="1">MSSAQQRLSQVASHFGPGGKKGVSAITEKHPDDIVVTCALRTALTKGGKGGFKDTAAADLLAGVFKGVIDRSGIDPSQVNDIAVGSVLPPGGGATEFRAAALVAGFPESTAVKSLNRQCSSGLQAIVDIANALKSGMIDVGIGAGVESMSSQYGPGAVTEFSELLEAHPESANCKVPMGVLSEQMAKDRNVTRAAQDAFAASSYQKAVKAQKAGLFNEEIIPLQVKWTDPKSGEEKTITVKADDGIRDGITPESLGKIRPAFAKDGSIHAGNASQISDGAAAVLLMKRSTAERLGQKIIGKYVAASVVGVKPLLMGIGPWKAIPVALEKAGITKDDVDIYEINEAFASQCVWCINELGLPQEKINPKGGAIAFGHPLGCTGSRQISTLLTELKRTNKKIGVSSMCVGTGMGMAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXU9</accession>
    <name>A0A370PXU9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_68427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXU9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="42815" checksum="3E4A6C5CA7F2EEAF" modified="2018-11-07" version="1">MLATPMTPQASHPSSSSNMVCSLASTATTTSSSSSSSSSSSSSSSSSSSSATQQTTISSRPKLTLQTTSLPRTFGTSSTGLSLSIAAGTASPTVRNTFKNAYEVTGPLSATASPSSKHPSNLRFSKPSSPFTTHNPYQLPLGVKSILRNSPLEPTCRRRAGSVATTGPNGGPSARRVFFPAKKQVSYRNPLEEEIQTVHYTARHSDLHDDPEPALEPQSQPQQPEVTSSDEDSDSNASGCPSDTSTSEDEPETGLGKTTSSPIKRKKRKHSNAERQVRAVALMDGIAGPSNPDSLTPQTPRRKRAKRRCEWRWTLGPLENRDKLLHPVQDETGPTSSASQPETIPHESETETPSSDPPLSSASTTLYHSSPSSSVSSDVETENDEWQTHTTHELECAHADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY79</accession>
    <name>A0A370PY79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_70321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="549" mass="59953" checksum="4CDFA15691C08C26" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYD7</accession>
    <name>A0A370PYD7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_245423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYD7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135495" checksum="CF44AE01C624D698" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYF3</accession>
    <name>A0A370PYF3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_289325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYF3"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811683" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17514" checksum="BC8A4A5F46F1D36F" modified="2018-11-07" version="1">MKLILTATITTLLAALTCQAAPSFSFRIGYRGSTEYAVAKPDAENANETIAFSSLNTYGLQGLDQWESSNTNQGFMIRNVALRSYISCSGQSATCDLTEDEGTSFQSIQTTNIDGVNYYHLFATTIEDIDGGLTWVLEGGDYLRIGVLDVKNERQEISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYH0</accession>
    <name>A0A370PYH0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_71526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18658" checksum="2181E4E23C0D51B5" modified="2018-11-07" version="1">MDLSVLLGSFSSLRPPQATYSYSSQKPFKCGFCGSHYKRGDVLRRHWKSCSARIHAGQTIPGPRIGGKERHACDVCARLKKSCDGGKPCLECATRRKDCTYLRLQESGGSPRNQHTPSPTLNKLQPEPINPIPDVALPTWDLGLQPYYPNHQTRLKARALRDGIQSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYJ4</accession>
    <name>A0A370PYJ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_228330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYJ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="939" mass="104549" checksum="36890B4BEBB7BB69" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN2</accession>
    <name>A0A370PYN2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_72153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="135" mass="15020" checksum="EA974B0CE5586EDE" modified="2018-11-07" version="1">MSNNQQPQSPRHWHGTVGDRYEHHNVWVRGGPPEPYRRPSIPTTTAATATSDRRGSDSSDMSSNSANLSNSPPSIGDRRRSTGHGASSLFESLTSQKRNSTDQTLNTRRESWNEQGQQGGFFAKWWDGYTRGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYT4</accession>
    <name>A0A370PYT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1742-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_73080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="22668" checksum="570D34436AFC3D4D" modified="2018-11-07" version="1">MSMSIQNIWHLRRVADTAAKACYICYKPSSSVLITPDNRDYFYVCPSHLQDRHFCSPIVDTEAVAAKAKDEAMAREIEKVKKEYEEKQQRKKNKDAEKEKEKKNDDNKDKEKDDKSATKKGDEEDKKMQKERDDKIESIKKSTTSSDDSPRVFALHKNFYQMRIDRMRNAEMARRNRQRLQDPSLFPSVPTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF3</accession>
    <name>A0A370PZF3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_260934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="673" mass="75770" checksum="53F96D802CA0A0D6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZQ4</accession>
    <name>A0A370PZQ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_331454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="10"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2031"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2373"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3151"/>
            <end position="3174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3154"/>
            <end position="3165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="3186" mass="359656" checksum="CA10F63BCA056AA5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q007</accession>
    <name>A0A370Q007_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_5187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q007"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="37380" checksum="4167F2230CAD7055" modified="2018-11-07" version="1">MFRILESQAPAKQTATDTINTLTGRLQSATLLEDRRAAIQGLRSFAKSFPASVASGALRPLINSLKDDREDVDTLKVVLETLLMLFTPDENSPEASDEIALWLSDEFTQRQDNITALLDLLDTRDFYSRLYSLQLMFQISSARPERTQECILTAPLGIPRLVSALGDAREPVRNEALILLIALTPASEEFQKLVAFENAFDLIFSLIETEGALTHGSEVVEDCLSLLANLLRLNISNQSYFRETGCVKRLAKLLADVNQEQDLEEPTPQWALAHRDKNLWGLLVIVQLFLIKGGVNTPANQTAFWNNGVMEQVLNTAFGQRFNVNVTSKVGKTDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q014</accession>
    <name>A0A370Q014_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_288254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="602"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1327" mass="149904" checksum="FFD4EE97F837E355" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q090</accession>
    <name>A0A370Q090_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC fatty acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_244067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q090"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="119"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="462"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="706" mass="80779" checksum="265848D8D86C068C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q134</accession>
    <name>A0A370Q134_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_11093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q134"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="121" mass="13662" checksum="3C93C3C87DF09847" modified="2018-11-07" version="1">MEDRERNGKHQLTSGNDGKGDLFRTDIASLFPLSFTSCSLTSGGGSEKEVGWKKKKKNEKKTTTMEADEEEEEWAAQEEPPRDWDSASLGRGQQVVRSSGKRIERESEKKRATTSRPTRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3E5</accession>
    <name>A0A370P3E5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_287864</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851890">
        <property type="protein sequence ID" value="RDK36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3E5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="17">
        <location>
            <begin position="322"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="55667" checksum="BDA4598E24218379" modified="2018-11-07" version="1">MPQSPMSNTIQKTPSFINKTRSRISEPVVAAFIAGGVAGAVSRTLVSPLERLKILLQIQSVGREEYKLSIWRALVKIGKEEGWKGFMRGNGTNCIRIIPYSAVQFGSYNFYKKFAESSPNAELSAMQRLLCGAAAGITSVTFTYPLDIVRTRLSIQSASFEALSHRGVGEQLPGMFTTMVLIYRNEGGIVGLYRGIIPTVAGVAPYVGLNFMTYESVRKYLTPEGDATPGPLRKLLAGAVSGAVAQTCTYPFDVLRRRFQINTMSGMGYQYASIMDAVKAIVAQEGLRGLFKGIVPNLLKVAPSMASSWLSFELTRDFLVSIDLDRHHVRGTHRKAPKSENVYLQVLVKLYRFLARRTESNFNKVVLRRLFMSRINRPPVSLSRIVSNVTDSHKGKTIVVIGTITDDNRLLTVPKLSIAALRFTATARARIEKAGGEVLTLDQLALRAPTGANTLLLRGPKNAREAVKHFGFGPHSHKKPYVRSKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3F2</accession>
    <name>A0A370P3F2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_243592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3F2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="367"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="57119" checksum="19E6D7C71F8370B0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3K6</accession>
    <name>A0A370P3K6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">67 kDa myosin-cross-reactive antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_287821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851882">
        <property type="protein sequence ID" value="RDK36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3K6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF4">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="504" mass="56833" checksum="D19815715ACF3782" modified="2018-11-07" version="1">MAGMSNPQRRDPSNVQAWLVGSGMACLAAAVHLIREGSCHPYFHGNCMKHLLSIIPNPGGGSKSMMDDIYFMEKTQRQPPQDFAMTRALRLGDSGPQVVPTRGIQVGFKHRLELMKFLLERERSLDAKSICQIFEQSFFKTGFWMLWSTAFALQPWHSAVEFRRHLRKYLEDIQHINDVKKAYRTKYNLFDSITLPITEFLKGEGVDFRFNTEVTDLLLYPESDPTTVSEIKLIKDGDECLIMLDPEDICFVDPGYSRSGAVFGSDNASPPYLTSNWEDLMMKEWKLWQKLSDKSSKFGNPTNFLLRALESGVETFTTTLWGPQFMNLYEKLTRDRPGTGAMLSLTDSKWSISLTIPYQLIFPTQPLDVHVICGYALSPSNEGNFVVKPMFACSGQEIFTEVLSHLGFPVQSVLETATIIPCGLPLGTAPFLTRGNEDCPHVIPPYTTNIACVGQFAELPEDTTLSVEYSVRSAQTAVYKLMGLRKEPVKTKKNILLELFDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4I6</accession>
    <name>A0A370P4I6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_109768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4I6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="76" mass="8290" checksum="38EAAFB09F7C6280" modified="2018-11-07" version="1">MSSAAPLPSFSLSPLPSLSPHSHHPFGIGEIFILSVLPRSRGATWQKSRPCTRRGAARVNRGTLTLTHTHTHHSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Q0</accession>
    <name>A0A370P4Q0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_110752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Q0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="268"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="413" mass="45416" checksum="D5EEE8039DA35513" modified="2018-11-07" version="1">MFSEGHGPSGAASGSQEQQGTTSDSSPSSTLHVSAESPSQPTLLDRFEMLATRVPDYYITPFCGASAGVASGIVTCPLDVIKTKLQAQGGFARRRGKAVEAKTLYRGMLGTGRVIWREDGIRGLYQGLGPMLLGYLPTWAVYLAVYDRSREYFYETTDSWWLSRGYASITAGACSTLATNPIWVIKTRLMSQSLRSSSEGYRAPWQYKNTWDAARKMYRSEGIRSFYSGLTPALLGLAHVAIQFPLYEYLKMAFTGYSIGEHPDTGSSHWVGITSATFLSKVCASTATYPHEVLRTRLQTQQRTSPAASPEEISFRGGMDHPQGHSRPPGAASSDGMPNRPRYTGIIRTCQTILREEGWRAFYSGIGTNLFRAVPAAMTTMLTYEYLKKTIGHVQHEGELKLQKLEATSDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P571</accession>
    <name>A0A370P571_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_107413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000577">
        <property type="entry name" value="WD domain G-beta repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="8">
        <location>
            <begin position="528"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="456"/>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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</entry>
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</entry>
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                <person name="Strasser K."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 13157</strain>
        </source>
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        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="RDK38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="269" mass="30011" checksum="11987396D60057A5" modified="2018-11-07" version="1">MPVASLYLLAINTDTNAFLKSLRSSRNVIVSSRPRHAVIRPTILDQDILTKTPWDLLVLIQTPTDVPPIPSTLQSQIKSQYRVTVGIPSKLLATYASRDESLKRTASSVPLTGSLDQARSKPTSQSLELSPDLLAFMDKLTPHHSGPVTMLNLLHFNHPNGKKSYYQYGQSFIPVAGKRGGDAKIVGNVVKPKSGTADAVDSRGDWDRREEDWWNEISIVHYPSIRHFCDMLAGEDYQEINEKYRLSALRDTFLLCTTEFDVEGASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M4</accession>
    <name>A0A370P7M4_ASPPH</name>
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            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PKS_ER"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="37598" checksum="38EE480D67FE473E" modified="2018-11-07" version="1">MGTPPNMTALVVRVTDGQHPKLSKEEIPRPSPASNQVLVKLSHAAQNPTDVQSFDSNAFGDGAVLGCDFVGEVIELGSDVARLSKGDIVAGLAWGGEVKGLGAYSQYCLADERISFKLPTNADISRAEASTIPLAAATAWLALFSKGCLALNRNQAKGTRVLVWGGSSSVGLYTIQLASLCGFEVVTTCSPKHFNLVCASGAKYAFDYRDKDVAEQIRGLAPGLRHVFDTIGNATSSATASRALHPGLGNLCTVRPGKANTKNVVPGTRVTDVLVWTAFLKDHSYGEFKWPASRDDHELTSELFEKLPGWLEKGSLKPNKPKLLKGLDAVADGFQEYRDGKISAYKIVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7P4</accession>
    <name>A0A370P7P4_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_308064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7P4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="340" mass="36850" checksum="E48EBC67743EF44B" modified="2018-11-07" version="1">MAKIFLTGASGYIGGDVLHALKSALPTCQYTVLLRDEAKALKLSQAYPDVQVVLGDLDASSTLEKQAREADIVIHTASSNHVKSAEAIARGLTAPERPKPGHWLQISGASVLSIPDIVASAFGEPSNKIYSDVDGADELRELIRQYSAKRVVDNLVLSLPHTSSRPKTALIFPPIIYGRGRGPINQRSIQIPELARVTMQRRGGVQVGRGEATWSNVHISDVSNIFVKLAEKALQSEEGKLWNENGLYFPGSRAISFGSISARVAQEVKKLGLAESESVTEISHEEADSLTPHGGVLWGTNAQQVAQRAAKYLKWVPEGRTLEEEIPHTVLAEAQRLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P886</accession>
    <name>A0A370P886_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_297360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2006"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2108"/>
            <end position="2118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2118" mass="232811" checksum="C743312EB242666E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8D9</accession>
    <name>A0A370P8D9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_297240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8D9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="29444" checksum="5133186641113809" modified="2018-11-07" version="1">MSISSSCWQSGKQAGTVSLGTHCVYLAANGPQRLIIRGRLQPAVIIETRLCSGLSEWVAISRLIAQRARIYSYDRAEDGRSEPSPNKQYTAKNRNLELATMLTPLPPDTFSLLGNLSYYEIVGLDQNHVVSEEEYEMIKTEEKRNILKAHIEESFMEESTIAVNDALPEGYSIIGNKPLSVIFANESVDFTKIHHHAVENSIGTGDARQRLAVRLKDMMQADEGLSMQSRFIYVEGKAQTHNLQYVTPKVIRAEVFWVLGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8X1</accession>
    <name>A0A370P8X1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_307757</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8X1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="20">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="203"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="530"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK38434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="62885" checksum="1CECD8904799F96D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Y7</accession>
    <name>A0A370P8Y7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_256918</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Y7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="426"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK38629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="899" mass="99674" checksum="E97D05E9581C9C77" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P960</accession>
    <name>A0A370P960_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_222114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P960"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="50684" checksum="B9A906EF2C8EE1DB" modified="2018-11-07" version="1">MSSTNTPFRAIIVGGGPVGLAAAHALHLAGIDFLLLERRPAIVEDRGASLIVHPHTLRVFDQFGILDDLLPHGTELNHHLSFTADGHVFAEGNRYKLIRENHGHAPFAFHRAKLIEIMYTGLPDQAKQRILTNKSLVDITTTSDSVSATCADGSIYHGSILIGADGVNSKSRHLMRSLALREDPTRSWDAESPYTATYQLLFGSFPSPAPAEAGQGYDVQSKNKAIMYFNGPERGWFFLYKRLPAPTSSRTTYTQEDVEDLASEFAEFPLTRTVKVKDVWPRMLGAGLTNLDEGIVKHWSFGRVVLVGDACHKMTTHLGLGFNHGIQDVVVLCNRLQKVVRAAAAASGSGGPSAQEIQGLFEEYQNVRMSSVCSLEWDVVKSGLETRMHAWHNAWYYLVSRWLSVSNVLEALFMKYVMAPEFRKGQVLDYVPREERMKGNISWIYPMGSTAAKEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9J8</accession>
    <name>A0A370P9J8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl aminopeptidase papa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_286054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9J8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="127"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="57872" checksum="8698EA44128CD3C2" modified="2018-11-07" version="1">MGQLREGVETDGKLNRGSTYRIVKRRYRYSLQLLPKRRLNDRPPPAAVGPILPVKPPQNASSLRKNVANDRWGYPGRLRVAELFFDVPLNYSKPNDGTLRLFARSVRRLVTPAEPSETPKDDKQLPFLVYLQGGPGMGCRPPQEYGWIGTVLEKGYQVLFLDQRGTGLSSTVTAGTLARQGNAIKQAEYMKNFRADNIVRDCEAVRRCLMTDYPEDKRKWSIIGQSFGGFCAVTYLSMFPEGLAEAFICGGLPPLVDNPDPVYARTYEKVLERNKAYYAKFPEDVERVKQIIQYLKDNEVALPTGTLTPERFQQMGILFGMHGGLDSIHDLVLRAWNDLDVFGFLTHPTLTSIDSFGGMDNNIIYAILHEAIYCQGKPSNWSADRLRASNPDFQIDSNKPEILFTGEMVYKDMFDSYTELSQIRDAADILALTDDWPALYDEAQLARNEVPVYAATYIDDMYVHFDHAQNTAAKIKGAKQFITNVMYHNAIRSKSDELIQQLFALREDTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9W9</accession>
    <name>A0A370P9W9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">M752DRAFT_338712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9W9"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="178" mass="20808" checksum="394ABE7955BDF037" modified="2018-11-07" version="1">MKAYWYDNKPGDQREPHDDGRPVDEAYLASLGVFYKYCPSIEDVDALAAERGYKNRDEVTVSPKTMGDVYEEKVKMFFHEHLHEDEEIRYIRDGEGYFDVRGKEDEWVRIKLVKDDLIILPAGIYHRFTTDEKNYVKAMRLFQEEPKWTPLNRSNELDENPHRVSYLGSLGKAAVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA16</accession>
    <name>A0A370PA16_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_285847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="531" mass="60837" checksum="59E321AAB35B6E3D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA4</accession>
    <name>A0A370PAA4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24001" checksum="D4DBBDB995755082" modified="2018-11-07" version="1">MTLENDAVAGATIELLETRLRRLTYLLTGDANWTGNPTPPAKPASLDDSVSRRLLRLERDLEKLSRNIPAVRDVLSLHDRFPDLFRQTPSKSLPESLSTQNLASIVLSYASAFPETASRLTSLNDLPIPNAETSASLIQLQPRLDQLAQTQDDQAKQISELRVRSARVLQRWYEVALVSGGECWAEWEGRLEDVEREVKREEVVRERRAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAE9</accession>
    <name>A0A370PAE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_329331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="316" mass="33957" checksum="15C9642B22ED3EEA" modified="2018-11-07" version="1">MTTTTSTPSSITFPSATHTLSGHLHHPQTGNSSSSITAGIVISHPMTGVKEQTAALYARHLSAAGFTTLTFDAAYQGASTGQPRGLEDPFQRVEDIKAAVTYLSTAVRGVDNSRIGVLGICASGGYACFAAASDVRIKAVATVSGACVGKMSRCGGVQKELRENEEVIGAVLGGAAGDRNKINHGEEEEKAPKMFDAEKVLQEGGNVDSFFRAAAEYYGTTERGKHERSTQRVPLQSYDRMVVYDSFAFMRLIAPRPVLMIAGAEAETLHYSEEAVRLAREPKELFVVQGKNHFDLYDQLEESGPKLVQFFTGNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB43</accession>
    <name>A0A370PB43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase mpkC</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_269007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="48436" checksum="A003F35F45723D85" modified="2018-11-07" version="1">MAEFLRSQILGTTFETTNRYSDLQPVGLGAFGLVCSAYDMITRQPVAIKKMMKPFSNATLAKRTYREVKLLKHLRHENLIGLSDIFISPLEDVYVASAMGDSNELFARVLTIGRSYLVTDLLGTDLNRLLTSKPLDGKFVQYFTYQLLRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQEPQMTGYVSTRYYRAPEIMLTWQKYGMQVDIWSAGCIVAEMLRGKPLFPGKDHINQFFLITDALGNPPDEVIERICTKTTLDLVKSLPKRQPAPWATLFPDSDENGTYPFHNQTTIDLLGEMLIFDPDKRISAAKALEHPYLSVYHDPTDEPVAEQLFDWSFSEVAHSIDEWKIMIYTEVVDFHDIGPTEEPVITEPFLSPDPSLSPEVLDPLGQIQTQSMVTKSAETLDQDILQYLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB70</accession>
    <name>A0A370PB70_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase/carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_56911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB70"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="28060" checksum="623CE0D0EE1CD68A" modified="2018-11-07" version="1">MPTPPTHSHFPSHLTLTITPPSLSSSTTSQSSPNILLLLHGIGDTSQNLSTLARALNLPETTILTLQAPTPLPFDLGGFHWGDDITFSPAGDLDMDVGFSRSTKTIIQEVIVDTLLKKCGYRGRDIIVFGIGQGGMVGLEVARHFKDFSEGVKDGDRELGGVVSIGAPVGLSGKAPASGTGKSRTPVLVVAGKEDGGERSTAVSAAGVRRTKEWFEFVEVSRYKRRGDGMPRNADEMRPVMEFLARRLRSYKGVPEGSIELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC32</accession>
    <name>A0A370PC32_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_278174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC32"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="200" mass="20567" checksum="6385114D801157FE" modified="2018-11-07" version="1">MGLLYPAGVVIVAAAVVGLYYLFRGEGEQINIGYFLESVSPYAWANFGIAMCIGLSVVGAAWGIFLTGSSIVGGGVKAPRIRTKNLISIIFCEVVAIYGVIMAIVFSSKLNLVEGDEAFSGSNYYTGYALFWGGITVGACNLICGISVGINGSGAALADAADPSLFVKILVIEIFSSVLGLFGLIVGLLVGGKALDFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC61</accession>
    <name>A0A370PC61_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_268805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC61"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="138" mass="15513" checksum="8C3D28D309000E85" modified="2018-11-07" version="1">MANKTPILAALIGYQADLSDVERKHTIPLWPMSITHDGAMMPTYAHYLWICNANRVSIDPSRPPADAWMMTMAMAKNIVAMLCSGSLCWVVFKVTRRILPVVPVPRQVSNPRSLRVQEREKGRHALASRQNAHYNTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCA0</accession>
    <name>A0A370PCA0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_285641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="60196" checksum="198051E8411F12E5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCQ7</accession>
    <name>A0A370PCQ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_277872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCQ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479871" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="209"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="439" mass="48898" checksum="41AF209B3996DF68" modified="2018-11-07" version="1">MRTSTLLLLWSTAGAALASPYPLPDSQVVFAADHEVPNTQGQHVVDEAILSALNAHSDPVAAMVSLRPETAAFLAEPRLLHIRGEEKAEWMTEGDKLRLRQRGKKFMDITEHQDFYAEQAMASFAGDPNLPKLSHKGLVKPLFSQIETERMHDILQHMTSYYNRYYGDYHGEMSSEWLHDYIAAIISKSPFRTHISLEYFTHPFRQSSIIARFEPKVRSFSQPLTIIGAHQDSANYLFPLLPAPGADDDCSGTVSILEAFRVLAENGYTPKDGPVEFHWYAAEEGGLLGSQAIARYKKEQGAKIGAMMEFDMTAFIARNATETIGFVATQADAALTNWALNLSREYISIPAEVYELGPNAGSDYMSYTKLNYPAAFASEGNPLAGGSFPGEMDPYVHGIKDRMDVDDETGFFSIDHMARFSELAIAFVVEQAGWDNTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCU5</accession>
    <name>A0A370PCU5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="8309" checksum="654EB015044B42CB" modified="2018-11-07" version="1">MLRSPPWHVEKTVNDGSMDLPIIVLCWLGIPAILGSATPSCHRLDKMVCGGGRSASSLIGGVNFPLGRDIGSEIEQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCY8</accession>
    <name>A0A370PCY8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_328668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="431" mass="49004" checksum="7EEE3F42F89A7D48" modified="2018-11-07" version="1">MNVNRKFDRFKQWAGERMGGEAKTTLSDDFKALETEMNVRHEGIDRIHKATGSYIKSISKRSEGDDKEKTLPIAHLGSSMVGHGEDFDANSEYGRCMTMLGRAEERLARLQDAYISQVNAGWLESLEHSLTQMKEYQTARKKLDSRRLAYDTSLSKMEKAKREDFRVEEELRTQKVKYEEANDDVSRRMQDIKDSEVDGVANLEAFLEAQLDYHERCRDVLLQLRYDWPSRAQPPSTRRPGRPRSNTAHSYHERYEPLHEETDNTADLRPIIRSTRASSIEPAAREVYPPDAFSQRPALNRTTTFEGPTQLRQEQSPGTYQWPSRAASDNYIGRRNSVQSRTMGRSYVDPYMEQSEEPSPISGTSPERTYMGRNPSPVSSYGGAVSRKSSSTTLNGTPLNKKAPPPPPPRSKKPAPPPPPMKRPILSAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD46</accession>
    <name>A0A370PD46_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD46"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="102"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="329" mass="38213" checksum="C3CFCD667542C0AD" modified="2018-11-07" version="1">MVSKKASHRPPPGAGLDAKPRNKIQRQLLHIKRKRAKDSSRRAERYAFKKEEAKNPKLKEERLKRNIPLTIDRKRVWDDAGSDVEDAAKFPSLFSTENPKSPKILITTSLNSSLHHEAELLTDLFPNSVYVRRTRHRFAHQFSIREISKFATNRNFTAVVILREDQKKPAGLDIVHLPTGPMFHFSMTNWVEGKRIPGHGRATEHWPELILNNFRTPLGLLTAHLFRTLFPPQPDIEGRQVVTVLNSRDYLFFRRHRYVFREKRETEKAVVGSDGKEMKGAEGIRAGMQELGPRFTLKLRRVDKGIQRASGQEWEWKGQMEKTRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDX0</accession>
    <name>A0A370PDX0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_42761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDX0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="215" mass="23973" checksum="EDDC90245ED592C1" modified="2018-11-07" version="1">MANRQITRRILISAAIAIFLLFVFFIRPEGPPSPAIRAPGHLEKSTQAVVSKDDLTKGEVVMPRLGNATAKAELGRATWKYFHTMLARYPEDPTEEQQETLRSFIYLFARLYPCGECASHFQGHLKKYPPQVSSRNAAAGWGCFIHNEVNTMLEKPIFDCNNIGDFYDCGCAEDEEGEGTETLKDKKSQGAARDEVDSVEAISLVEISREPTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDY4</accession>
    <name>A0A370PDY4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_43017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="31041" checksum="C6B0FCC2AB0076A5" modified="2018-11-07" version="1">MGKKRKRPIKGDRALDRLSQPCTSPASTCFKGLRSLARDDAAEHSHPVISLYYSQVVTLRQYLLCQIPLSSKSRRRRIVSICHEPAPAKTSYDGGSGGLLANLLNTTLVGILTDSPPTCNEKRRQELAAFTQSQSRSEQASTDTGPLCAQAELVDFVISSLFNRDRFSRQKPLHLLTRGYRRVSAHPAHYGNRTVSCSIAGLEVQFPNDNVQQLKQAPWTEVLGLLGDNGEEIMLKLLLDCGIFVAVDQKRGIYFQLSGATKPFDTKECTSSLSNKQACTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEA8</accession>
    <name>A0A370PEA8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_253546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62122" checksum="C599646FA910CED4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEN8</accession>
    <name>A0A370PEN8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_303339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="275"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="496" mass="53313" checksum="DA47B513B5A18B3E" modified="2018-11-07" version="1">MTSTTKPTEKQDKSTLQLIKEKLKMNPSTEHLTVRDDFELQPPGQADSNESLENATNISTVEDIPPNGGYGWVCTFCVFMINVNTWGINSAWGVILDYYLSNSTFPGASHLDYAIIGGLSVSLCLLIGPIVTKSNELLGTTITLLTGTALIFTGLFAASYSTQVWHLVLTQGIAFGFGMGFIYLTATSILPKWFSTKRSFSSGIAASGAGLGGLAYNLAAGRAIQTMGVQTTYRILAFCALGSHLVSSLLLKDRPRSRAQPRQRTFNHRDLGHFEVLLVIVWGISTDLGYITLLYSLPNYASSIGLSPQQGSVAGAILNLGLVLGRPVVGYISDTYGRITISMVMTASCAILCLAIWIPAHSYALLLLFAVLCGMVCGTFWGTVAPVLTDVVGLNRLPSTFGMVCLMLVAPNLVAEAIALSMAGGGAGYLSAQVYVACMFVLGAVCLWILRSWKFYELEVKGVREGGEVRNGAGMAGVQGFMRWMRPGKLFLRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFB2</accession>
    <name>A0A370PFB2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_277517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000004">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="713"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="809"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="863" mass="95828" checksum="D74694BA9D6830EC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFJ3</accession>
    <name>A0A370PFJ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="10250" checksum="A15CB4CB25A4688D" modified="2018-11-07" version="1">MPAFLKNIKNKLKAIFKKKKTAEENPEGAAAPAENTPAADKPAEPQSEGVSAAPPTLEVTETPAGEAKPETETHAEAAAGASEAAAKPAETAGDAADKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFN2</accession>
    <name>A0A370PFN2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="2">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="284"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58877" checksum="117C7E6D67D29BCF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG42</accession>
    <name>A0A370PG42_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_336968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG42"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF8">
        <property type="entry name" value="O-METHYLTRANSFERASE AF390-400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="45131" checksum="73866A887880367B" modified="2018-11-07" version="1">MLHQAKDIVAALDAVQPLSSGTDEVDRLAIRAAAYRLLNRVETPHERACGFCFENPIVFAALQTCIDLNLWKSWTSLGGGELTVDELAALTTPHVDVNLLRRFLRLLAAFNVVEETGPDKYKSTPFSYAIGDDSTKIKATLQAGTYQYFPAAYNLPTYLAKTSYQEPTDMNKNNYSDFDPAGLNFFARVEQSPSHFEAFMGHMECWTALKTPWTDIYDTAKLLHDGEPNDHSPFLVDIGGNTGTDISYLVNKHPELRRESVVLQDLPDVLDKIQPPLEEKITPMVHDFFQPQPVQGSRIYFMHAVLHDWSDEHARTILTHTRDAMKKGYSKLLIYDIVLPPVKASMSQAAMDVQMMSLLAGSERTEGDWRKLITDVGLRICRFWPDRQQFEMLIEVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG53</accession>
    <name>A0A370PG53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_284635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05664">
        <property type="entry name" value="M20_Acy1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="425" mass="45741" checksum="F11BD3510CE6E0DB" modified="2018-11-07" version="1">MQLRHAASQTALKDILEEARPDLSPFEDIYRDIHSNPELSFCEERTSAIAAQHLEELGYEVHTHIGGYGVAGVLRNGAGPTILLRADMDALPVHEKTGLPYASTKVARNKDGVEVPVMHACGHDTHVVSLMASASLLQSARTHWTGTLICLFQPAEELLSGSRAMIDDGLYDKIPAPDVVLAAHVMPLKAGTVGIRSGRLLTAADSFNVRIFGKGGHGSAPEACIDPVVTGAAIILKLQTIVGREVPPGQLAVVTCGYIQAGIAANVIPDTLDFKLDVRTCDDSIRERVIRAIKRIIRAECEAAGCEKEPQIDHIMSTPATINDHATVRALCNTFGSYFGKRLVEPDPAGASEDFSLLARAVNAPYVMWTYGGIDPETWDNAVKNDTVKDLPSNHSPFFAPVIQPTLQTAVDAMSLGALTFLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGM7</accession>
    <name>A0A370PGM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="21212" checksum="DA59CB19552C5CC5" modified="2018-11-07" version="1">MLTSSSTDSSRSSFSGSPVSQHPPHHQVWFPPAPRRRPEHYKIPRYYSTPVREDVPDSTPLQMYGLEERAPSIAEKPKLLRRFSHALDDIKEDLTLQPSSEKIRSKRRQSIFGIDEIPGSSGSISSPSMDVPVAAEPRPPRSRPLSILASEPSRRLSRRFSIFGSKRSKKLTPGQAGSTSQPNLIGASTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGP5</accession>
    <name>A0A370PGP5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_276865</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGP5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK41377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="178" mass="20192" checksum="BDCC351361AA9341" modified="2018-11-07" version="1">MKQQQQQAENAEGAAGKKKKKVTAAQLRVQRDLQELTLGSTMKMSFPNPDDILNFTLTIEPDEGMYKGGAFHFNFTVNQNFPHDPPKVKCTQKIYHPNIDLEGNVCLNILREDWKPVLNLNAVIVGMQFLFLEPNASDPLNKEAADDLRQNREAFKRNVRTSMGGGSVRGIQYERVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGW6</accession>
    <name>A0A370PGW6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_26724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="489"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="662" mass="71920" checksum="A4051EEF39D9DA78" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGY4</accession>
    <name>A0A370PGY4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_266974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="45"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="62319" checksum="0322E0C2B16309F2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIN9</accession>
    <name>A0A370PIN9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_276740</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF4">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="14">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="440" mass="48429" checksum="65025CC4A73DD566" modified="2018-11-07" version="1">MTPNWSQLWAFITNPKDPSSSSPSPYTLRRIIKSLSLLTVFSILLYALYIHFQPSIIPQNPDLPDPDLPPSPEDSYKSIYGYPPTNPTIPPLHIHDPSILYDLPTNTYYAYGSGPHIPIHSAPTLQGPWTKVGTVLDADSILPKGDRKAPWAPTALVHDGTFYVFYATSHSGCRDSAIGVATSTSPGPGGWEDHGAIAISGRGERGKEFPFDRANAIDVSVVVDYTDTQTQTEPSEGEISLEEGKKGKGKGKGYMTFGSFWTGIWQVPLKPNLLHMDKQGEDEERVKHLAHEPAAIHPPTKKADGLCGDTTGMHPIEGAFISYHEPWWYLWFSWGKCCHFDPEKLPRAGLEYSIRVGRSSSPQGPFVDKEGKDLVDGGGEIVYGSNGDVYAPGGQGVLSGEVEGDVLYYHYLNISVGYEFKEARLGYNYLKYVDGWPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIY8</accession>
    <name>A0A370PIY8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_235461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="608" mass="65161" checksum="4BBD1FBEE1BD616E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJC8</accession>
    <name>A0A370PJC8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_215623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016728344" description="mannan endo-1,4-beta-mannosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="39"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="41300" checksum="B1A62B6896E0815F" modified="2018-11-07" version="1">MKLSNALLTLASLALANVSTALPKASPAPSTSSSAASTSFASTSGLQFTIDGETGYFAGTNSYWIGFLTDNSDVDLVMGHLKSSGLKILRVWGFNDVTSQPSSGTVWYQLHQDGKSTINTGADGLQRLDYVVSSAEQHGIKLIINFVNYWTDYGGMSAYVSAYGGSDETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCDTSVLYNWIEKTSKFIKGLDADHMVCIGDEGFGLNTDSDGSYPYQFSEGLNFTMNLGIDTIDFGTLHLYPDSWGTSDDWGNGWITAHGAACKAAGKPCLLEEYGVTSNHCSVESPWQKTALNTTGVGADLFWQYGDDLSTGKSPDDGNTIYYGTSDYECLVTDHVAAIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKE9</accession>
    <name>A0A370PKE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_326466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017043428" evidence="2">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="43924" checksum="E1CB0644BF2169C9" modified="2018-11-07" version="1">MLRGHLLLLAIGWAGVLHALPNSQRRGTVNKRLQFTSNGTFQLTVFEDLHYGEAEDTDWGPEQDVESRTVINTVLNHESPQLVILNGDLITGEDTFLSNATDYVDEIVAPLVQRNLLWASTYGNHDSDYNLSRNAILDRERTYPNSLTTSMVLGKLAGVSNYYLPVYPSDASQSTPAVILWFFDSRGGNYYQELEGGSEVPQPCWVDQSVVSWFVETNANLTAQYGRVVPSLAFYHIPVNAMLAFQKQGVDTHEEPGINADDPLDQQGAASGQGEVSGTVFSYSGQDIPFTEALLNTKGLLATFSGHDHGDDWCFKWDSKLPGMNLTGYGLNMCFGRHSGYGGYGSWTRGARQILLDERTLSTQLSTWIRLEDGSVSGSVNLNATYGEDAYAAVPTTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKW4</accession>
    <name>A0A370PKW4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20175" checksum="2E80B455F2E03FA6" modified="2018-11-07" version="1">MAPHGLLGATFVCARIIQLCSLVAIIGLTANFIAEIVSNGATPPAIFIGTITVTSIAVIYSFITTILFLDNILHFLISAILDTLLLIAVIVVSVIIGKPLSYLQCNKLSSDGSSGSSAYTFATHLSSYLEDLSGGTVNYTAWIGASKSVCLEAKSIWGLCIAMCIMFFFSGVCGLVLWRQKKAAGVEKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL24</accession>
    <name>A0A370PL24_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL24"/>
    <dbReference type="SMR" id="A0A370PL24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="40787" checksum="DA3158057B4E2078" modified="2018-11-07" version="1">MYPNKSLILTNIPTGLPTPHKDLTPLPRPLDITTPPPNPHSLLTKLLYASLDPYMRGRMRPAHIKSYSPPYPLDSPITAYAVAQVVHSTHASFKTGEIIYARLPIQEYSILSISPASTSEAGGETWTLENSLDGANSPVQKIPTPLPSGIELSQYVGILGMTGLTAYAGLFEIGEPKKGETVFVSSAAGAVGSVVGQLAKRIGCRVIGSAGGERKRKYVVEELGFDECFDYRVEGAKEALGRLAGGEGGSGVDVYFENVGGEQLDAVLEVMNNGGRIVACGMVSQYNLKPEERYGLKNLYNVVTKRLRMRGFIVGDKDIGPKWIKERNEKVTAWLQEGSINAKEDITVGIENGPEAFVAMLRGENLGKAVLKIADPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLM5</accession>
    <name>A0A370PLM5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_214733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="39467" checksum="D3245EF2435A7423" modified="2018-11-07" version="1">MSLRCFEPVSIPTDASLSLSGIADVYHNSYNQGNHSAPAPPPSDPVSFGQGAPQGYNFQYSRCTGKRKALLIGINYFNQKGQLRGCINDVKNMSTYLNQNFGYAREDMVVLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSAGHGGQTPDLDGDEDDGYDEVIYPVDFRAAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSSMMSTAVGFFKKATKGDEAYERTIQTKTSPADVVMWSGSKDDQTSQDAQIAGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSAKYTQKPQLSCSHPLGKQSPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLX4</accession>
    <name>A0A370PLX4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_232700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000061">
        <property type="entry name" value="Laccase TilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016993210" description="L-ascorbate oxidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="173"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="462"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="65381" checksum="6162DEBE9D4B5947" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY4</accession>
    <name>A0A370PLY4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_265101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="143" mass="16993" checksum="FCE66052BE81FD98" modified="2018-11-07" version="1">MPLFITDNEDEYVRFVNQVENGSRLDEGQLGDELPPPLTYEEAIPPQALSTRHLSPDPVQDSPPRYQNGSGQSPSCEQPESPLTPEITDQNERNDSDDEGEVTREDKDDEGKQRRRRERRRVRRRERRRERRREQRRDRRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM49</accession>
    <name>A0A370PM49_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_265156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000093">
        <property type="entry name" value="BZIP transcription factor (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31509" checksum="AD0D9DB97CF5E710" modified="2018-11-07" version="1">MSPTPEPPTTKKRESRAGARKVTSLSAEQLERKRANDREAQRTIRQRTKEHIERLEHQVAELKAKGEQFDDVVRRNVALEHEIRALKHQLALASRQGYPGMEGTYSNAPGSMVPATQFAEPLGMNPASRAPSVLSTSSRVSVGSEWPPYGTNRSPSTCESSETNYGNRAESYLFESQLQPTSAMSVAPPQVSYSAPVGAQPDPTFQSYAQAYHTGNAPRGPVDDLASHPPQPVPYVPGQRPMSVPTIPTERPAGYPLVHAPQPYHQHTLPPQTRNDYGYAWNPHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMK0</accession>
    <name>A0A370PMK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_233015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="56341" checksum="261698C2CD5C42D8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMM3</accession>
    <name>A0A370PMM3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_213428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000004">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="43778" checksum="352646AF980E3077" modified="2018-11-07" version="1">MELPRQIEPGWGSASKQTPSQSTAAPKSDAQLMLENILQGTTQSMEQPAAESANKPQDAKPRLMLMGLRRSGKSSIASVVFHKMPPNETLFLESTTRIQKDSIHSFMDFQVWDFPGQLEYLEPSFDLESIFGSLGALVWVIDAQDDYMESVARLNRTILTVQQYYPNINIEVFIHKVDGITDEYRTDTFQDIVQLISDELSDAGYENAPVHYYLTSIYDYSVFEAFSKVIQKLIPNLSTLENLINTLSNNCGFEKTYLFDVLSKIYIASDTRPVDMSCYEMCSDYIDVIVDISELYSWDHPDRKAKGEQNQEAESHAVLHDDTMIHLMEMNKYLCLVSVIRNPESKDKKGLIDMNCRTFQEALNDVFSRSWEQDQEGPGVVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMY0</accession>
    <name>A0A370PMY0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_158340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMY0"/>
    <dbReference type="SMR" id="A0A370PMY0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF23">
        <property type="entry name" value="PLASMA MEMBRANE SENSOR TRANSDUCER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016861156" evidence="9">
        <location>
            <begin position="31"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="30259" checksum="066B677F4FC4C863" modified="2018-11-07" version="1">MFHTTKSFTMRSALAASALLLSISLPATHAYTEEYNGCYSDSTPLKDQGTYTYQSDGYCQKLCLKDNYSVFALHNGQDCLCGNLLPASSAKVDDSKCNVACAGWPSVECGGSNTYSVYLTGIENDVDHYSASSTSTSTTDSETSTSSTQEAHVVTSSGTTQTVYATSGTEASASATAEGATEASQKKSSSANTAAIAAGVVVGVVGACALAGAGFFLWRFKNRKSQYRRSVGVDNYGNPMSQHSMSDSRFDGDFMAQRRQSNGSIDDDQDFSRRILQVTNPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNK7</accession>
    <name>A0A370PNK7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNK7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF15">
        <property type="entry name" value="DEHYDRATASE (PRPD), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="284"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="475" mass="52476" checksum="76E7A257630E0F85" modified="2018-11-07" version="1">MSSTSDRQYDETITRLVEYVYHYEVTSDLAILRARYALMDALGCALETLQQSPECRALIGPYTPGLVAPYGFKLPGTCHQLDPVKGAFDMATLIRFLDHNDAYPGAEWGHPSDNLGAILAVTDWLSRTGATSQPLTVRTVLIAMIKAYEIQGCYQIRNAFNKVGLDHTLLVKIASTAVVAWLMGLTEKQAAVALSHAWADGHPLRIFRQSPNAGPRKGWAAGDAAMRAVHLCLLARAGQPGIPSALTEPEWGFLAVSFGGKELQLPRPFKTRVMEEVFFKLITAEGHGISAVQAAMALAETMASKGIDPATDISRIDIRTHEAAVRIIDKQGPLTNAADRDHCMRYMVSVVLLKNAIIEAEDYHDSSVWAHDPRVEALRQRIHMAEDPQFTYGYHHKKAAASGLTVFLTNGEQLDEVVVEYPIGHPMHEDTLPKVRAKFERNMQGLFTAEETSRVIDAIHQDKLPVHRLVDLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNW0</accession>
    <name>A0A370PNW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="565" mass="61315" checksum="9B9B9C8BCF8A49CD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP85</accession>
    <name>A0A370PP85_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_325896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14132" checksum="3A1FFD599E357C84" modified="2018-11-07" version="1">MSFLTRIAPAARTASLSLRPATTPVFSVGATRSISATARRDKGPIDATKDTLKKADRKVSDAAVKGIEVGENAAEKVKSTVGSTTAEAKAKTDELSGEASQVAGQGKGKAEEALGTAKGKAKEAAGEVKGKAKETAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPH4</accession>
    <name>A0A370PPH4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_150800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="15">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="38279" checksum="2085D3D6155EC0B8" modified="2018-11-07" version="1">MAAVSPAAARAEPGQWKKNLSAHVICPECKEVPPNLEFPGSHETVCGSCGLVLADREIDMHSEWRTFSNDDQNNDDPSRVGDAMNPLLNGDQLETQIASGGSGRVRDLYRAQNKQSSEKANKALLAAYKEIGALCDGFNIQKNVADTAKYLFKIVDDAKAFKGKSQDVIIAGCIFIACRQCKVPRTFTEIFAVTKVTRKEIGRIYKALEKFFTAQNLERINAVVSSGGVPDPNDTYTATTSTKPSDLCNRFCNLLDLPFQVTSVSSALSDRVTTMGDLAGRSPLSIVAACIYMASYLMGHGKSAKEISQVAHVSDGTIRGAYKQLYAERERLIDPEWIKDGKGDLKNLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPL4</accession>
    <name>A0A370PPL4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_292281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="516" mass="58832" checksum="3040217FB2F9BFB0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPQ6</accession>
    <name>A0A370PPQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex, subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8516" checksum="765AAE6C1F16D3B9" modified="2018-11-07" version="1">MLRRKPTAIAITSEDLATFEQSRLRQLSKETRTEGHASTSSNVNIDPSDELKPLPGDKARIVRSREERIGINRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPS0</accession>
    <name>A0A370PPS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="43167" checksum="EA7B65A62586C8D1" modified="2018-11-07" version="1" fragment="single">MAPPLPPHSESPARGRPDEDDEEEDYMSMIIEEPQQKETFAQKKKRQQREAEARAKVPSKAERAAQEAARRDAALSTSTLDPSNKGFQMMAKLGFKPGQVLGKPTAPSQDSEKDTKDPQDRIRSEPLNLIFKEDRGGIGLDSERKRKFLEEAAEVTKKVKQEEGDYRDRVRLERETRRLEAQFYAGQKVAERLDAEAEGEGEIEPPPTETNGEEKEEQESHAIPDVEGEEPQTDTSTSTTKKAKRPVKPTSQINILYRGLVRERQEKERAVQTRHMLQTSLPSSFFPNPRLPGYEDSTLDPEDHEALGGRREMSSILEQELEEEDPELEEFNALEPGERLGRLVQYLREKHHYCFWCKYRYETAEMEGCPGVTEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPX5</accession>
    <name>A0A370PPX5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_264168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="16871" checksum="D954730ED15CCC6D" modified="2018-11-07" version="1">MTECVCVTSSLYTPTYGAGGREKTSEKSSVVESLGGLLAISNYNDHFGSSCDAISDGAYTIKVTIYGSDAFVSPIYARTFPKLSKISYRVRNLEPTSIERPSYDSSVAESSKHVTSSMLHLPIVSIGAVSNKRPNQTYLHASHRREASRSSSYTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ45</accession>
    <name>A0A370PQ45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_274686</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="195"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="556" mass="60067" checksum="8D6AE1DF1F8F1B59" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR84</accession>
    <name>A0A370PR84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_274038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="94"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="26537" checksum="0A5B0B5D329F6F1E" modified="2018-11-07" version="1">MTEQLQPIKLYGGSFGPNPFKVSIILHELGLPVEEIPTDFTQIKTPAYEALNPNGRLPTIQDPNTGITLWESGAIIEYLIEEYDKDRRLSFEPGSFEAHHARQFLHFQMSGQGPYYGQAVWFKRYHPERVQSAIDRYINEIRRVSKVLDGILSKQDWLVGNKLSFADLAFVSWQNGAKQMLPDEGYDESEFPYMAAWLERMNSRPVVRDLIEKQNKAMAERLSAATAALKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRM7</accession>
    <name>A0A370PRM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_211065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017002758" evidence="7">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="220"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="426" mass="48455" checksum="66FAD6D3A99004E3" modified="2018-11-07" version="1">MVTCKRPVILLILITFVTSAATHVFFPSNTTSSNTTGTPYNLTAPIIIDTFNNSHHNTLGFWHGGLEGLKIDYGRNYVRFYPTDPDHNYDTQLSPATCFNLLPYRTTHYLHLQFTGHTNFSVSLTQNNIHCDSTRSPFPETWDSVEAARYARGNDIYIPLWHFYIDHSRAVSVSFNGFYSPGAVTLYKVELVNAGSVPAGFPIPRRVDNGRVLLRCSRPGSFAFGIDDGQPKFAQEVMKILEEENILVTFFVVGLGLRDLETNFSSVYGEMLKRGHQVALHSDTHRKLEGLDSVEAIDREIVDNIKSFRQILGIESRYFRPPYGTLGARTRQRLAKYIKDPQIINWSVDIEDWLWADTKTPEKQREAFIRDVKRGGNLAVMHYLSPTTVQYFHEVIRFVKSMNATIMRIDQCLEDPQAPPLKIAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRU5</accession>
    <name>A0A370PRU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_248800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="302"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110240" checksum="6ED9B04F75876A44" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS09</accession>
    <name>A0A370PS09_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_333627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="21356" checksum="9FE3AD36CB7D6FC9" modified="2018-11-07" version="1">MDHSMHGMMDMDHGHDHGDMDMGDGQCSMNMLFTWSTKNLCIVFPQWRITSTWSLLGSLIVIVLLTAGYEGIRQLTRRFEAAHARRLSAYTTVAVGGSEVHDDSATANVPSSQTLPAPNTGSPLVVGRDSRRTVEQRGKITMAALYAVQVFYSFFIMLLFMTYNGFVMLAVAVGAFVGYLAFGDNTSASKTVACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS61</accession>
    <name>A0A370PS61_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_131566</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS61"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="51713" checksum="E9303251A9352B35" modified="2018-11-07" version="1">MSKSRRNVRFPRRMSNSSEGRRLSISDASDVLSDPGSPAKDGSVTAPATIPEEKSEKPQLSDYEKKKQTFITRTIWTFVMIFGFFVAMFSGHIYIIGIVTAVQIISFKEVIAIANVPSKEKNLRFTKSLNWYFLATTMYFLYGESVIYYFKHVLLVDRVLLPLATHHRFISFTLYVMGFVFFVASLQKGQYRFQFTQFAWTHMALYLIVVQAHFVMNNILEGMIWFFLPASLVITNDIFAYVCGITFGRTQLIQLSPKKTVEGFLGAWICTIIFGYFMTNILMRYKYFICPVNDLGANVLTGLQCSPNPAFVPQPYHVPEWTGMHKTFHIEPIQFHILIFATFASLIAPFGGFFASGLKRTFKIKDFGESIPGHGGITDRMDCQFIMGFFSYMYYHSFIAVFKASVGDVIEIAINGLSVEEQLEVVRGLSKYLYNQGTVSETILDCINTELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS97</accession>
    <name>A0A370PS97_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glucanase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_333948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS97"/>
    <dbReference type="SMR" id="A0A370PS97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF6">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017026145" description="Glucanase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="48258" checksum="6364A0F4BF7D254F" modified="2018-11-07" version="1">MHQRALLFSALLTAVRAQQAGTLTEEVHPSLTWQKCTSEGSCTEQSGSVVIDSNWRWTHSVNDSTNCYTGNTWDATLCPDDETCAANCALDGADYESTYGVTTDGDSLTLKFVTGSNVGSRLYLMDTSDEGYQTFNLLDAEFTFDVDVSNLPCGLNGALYFTAMDADGGVSKYPANKAGAKYGTGYCDSQCPRDLKFIDGQANVDGWEPSSNNDNTGIGNHGSCCPEMDIWEANKISTALTPHPCDSSEQTMCEGNDCGGTYSDDRYGGTCDPDGCDFNPYRMGNDSFYGPGKTIDTGSKMTVVTQFITDGSGSLSEIKRYYVQNGNVIANADSNISGVTGNSITTDFCTAQKKAFGDEDIFAEHNGLAGISDAMSSMVLILSLWDDYYASMEWLDSDYPENATATDPGVARGTCDSESGVPATVEGAHPDSSVTFSNIKFGPINSTFSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSJ8</accession>
    <name>A0A370PSJ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_274434</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSJ8"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="429"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="545" mass="57933" checksum="73B4148411583CE7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTG3</accession>
    <name>A0A370PTG3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_246745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTG3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="70154" checksum="B3FCB4314E869072" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTH1</accession>
    <name>A0A370PTH1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_333324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTH1"/>
    <dbReference type="SMR" id="A0A370PTH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016762557" evidence="1">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="41034" checksum="6ACA06E8079D8268" modified="2018-11-07" version="1">MVHFLSPLAISVAMLASLGLGHPGHDVKQEAAERAAFLKRAPAQSRSLAQCASTLKARGVEEGNVARRAKALQNLRRERGLTNTQYLKARDVDSVLDTDHHSNLTGVNPSTDPSVLFASGGTCIVQPEVTQGPYYIAGELIRRNVVEDQTGVPLFMDIQLIDTNTCEPLPNIYTDIWHCNATGVYSGVVASGNGNTNDESNLNSTFLRGVQPSGDDGVVRFESIFPGHYTGRTVHIHVVTHPANETKILSNGTIAGVYNGHSSHVGQIFFDQDLITEVEKTSPYSSNTQSLTENSDDSILETEADTTDPLMEYVLLGDSVSDGVFAWISIGVNSLRDDSLSPEGYWTEDGGEVNDDFEMNMAGMGDIAGAVPSSSASASATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU76</accession>
    <name>A0A370PU76_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_122044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="168" mass="18381" checksum="0C69A0C6E7928666" modified="2018-11-07" version="1">MSVSASIPDTSLGLTSSEIQILRQQQQIALQGGHGANGVSRGRGTGRTSNSSSRAASAASSHGRLILDPMSLRALSQQLDGLQQQIRNRLDDLEEQMQISIQSTYDRAGNVIRNADAEIARTRSILASIDDLENELAKIGHIREIVKAYRGRIEGLDQRLDQAARRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUE9</accession>
    <name>A0A370PUE9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_311948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="206" mass="23530" checksum="73BCDF7AF55CBF36" modified="2018-11-07" version="1">MLPTLLSPRLNLDPNVDDTIISVNITNECIAAYKELLYRRGADKPAFVIYKISDDERSIVVEESSPEKNYEAFLQKLTSAHDSDGKPAPRYAIYDVEYDLLEDGRRATIVFISWMPDVTSTRIRMLYASTKEQLRKALDVKVSIHADDVHDIEWKTVLREASAKTVQHNVALIIGAYIEKGTHYNPFGHIRECGIRYTKITRNDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUP8</accession>
    <name>A0A370PUP8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUP8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="436" mass="47319" checksum="678C90567CF308DE" modified="2018-11-07" version="1">MSVICASEGSSPVPTPLFSAPTTPETERDEYFDEPSLPVQDDAPYVLVTGGLGYIGSHTTLELLKAGYNVIIVDDLSNSFHHVFDRILLAAKQHFDRTDGHCPRAELRCIDFRDVPAMRALLASYTVESSSLDTSDSITQSRSRIVGVIHFAAFKDVNDSLRNPLKYYHNNVTGLVDLVSLLADHDIKTFIFSSSANVYGTLAQNHGTLREEHCVHQPETYHSASSGEPITSEQGCTGITNPYGRTKWIGEAILSDVATSDPSWTIIGLRYFNPIGCDPSGLLGEDPRGTPSNLVPVVVQVLTGQLPALSVYGTDWETPDGTAIRDFIHVSDVARGHTAALAAALAGQVKTNFRTFNLGTGRGHSVAEVVSAMEGVSHQSIPRRLAERRPGDVQECVAVPERAACELGWEAEKTLQDACEDLWHSLRGGSVEVMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW35</accession>
    <name>A0A370PW35_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="276" mass="30188" checksum="3A77AA3B3A7133B6" modified="2018-11-07" version="1">MARWPRALTPNHAASSTSSTMLFYLSLMSIALSTVVRAHTVTLLPSVASSDFPSCALTCSVLKEAQNECVPPVAAQTDHATYVSCFCQSALLDQIHFPTGVCTESCPSASDRALIRTWYDEFCSSEDTLAARDTTPSIFARDSRSQTWWTTHYQWVIMVIVLVVAFSVITVVGVWLKRRHDRKYPGLYHATNTAGTDSALLAARQQDNSPSPQPGPPPQGAFRPGRFDPTLNSESIASSSRTNITAPTTRPARSSSRLQKAQPVPEGDIEIREVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW46</accession>
    <name>A0A370PW46_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_332998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW46"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="19890" checksum="8EC205C49E823D70" modified="2018-11-07" version="1">MSAVSLTNQTRLRLSRGATCFKPSTLASRRLFSSSSSARFSLQSSTRTAVAPSFLRPTPFIHSRRAFSHTSSTMSHKVHDITSKAEFAEKVTNSTDAIVLDCFATWCGPCKAISPKVEEFSNTYPNAKFYKIDVDELSEVAAELGIRAMPTFLLFKDGKKFDDLTGANPKGLEQKIQALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW69</accession>
    <name>A0A370PW69_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTH11-like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_102579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="376" mass="42010" checksum="05D7033A04C91ECD" modified="2018-11-07" version="1">MLDEMMGGMLLPRTTDDGTARGQRALVVTAVLTGLSIVIVAMRMYARVGLMKLTGREDYMILISLVLSCTYLGLVAAEVHFGLGKHDADLSDVVVKEQLKRLWAAIPFYNASLIFTKFSILFQYLRIFPDRRFRLACWIVFGIVATYGTWAVVSGFLNCVPVAKFWNRNISGYCLSFEAVWFFNASMNIATDTTLLILPMPLLSQLQLPRMQKFALMGVFAIGGLVVITSILRLSSLRSVAKSTDTSYSNVGAAYWTAAECNVAIICACLPFLRPIVSRIFPRFLSTNSYNRYTRNPTMTASRMTATRMTARSHRQKVELYSQDRDYGMYTIDVKSGEASHDSALDGIAVTTTTMIQETSRNNDESTSQRRLVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWF5</accession>
    <name>A0A370PWF5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_290013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016670668" evidence="1">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="45110" checksum="96E70253DB7148C9" modified="2018-11-07" version="1">MQILKLCLAVATAAHVHGLIQDVPSLNGPVMMVPDTPGSKNRTNQFQHPGLWHSHSQLELMRNNVLKGVEPWASAYTRFAKDPYSSASYEMQGPYPVISRGQISNYTSFHDDSRAAYQNAIMWYITRNESHWNRSTTILDAWGSNLENIIGTDRSLLIGIEGSIFANAAEIMRWEGGWVEEGATFKGGSGLSVQLYWLFARQSIIIGQANYGMASIMGLLNFAVYLDDVALYNYALYAYKYDRCAGFPYNYLASTGQNSEAGRDQTHVQDALQWTALAARVVANQEYDLFALEDKLIFTAAEYAGKYLMNQTVPYDASFYRCEVVLVDGPWANISAINRYIGYQDGKTNPAAWGLIYYEALERGIEVPWTSRVKDVYDASVKGQTSPVDPFSWADLLFAVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWG5</accession>
    <name>A0A370PWG5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_209256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="54097" checksum="537117B48ECA098A" modified="2018-11-07" version="1">MSIEAGPPTTINGTEVLPTKQWARVLEALFSESLLAKVWFVASKAMGSTTPPTFYPEYTGEDKTTYIYRTLDFWTSGFFPGSLYLLLERSTLFRDRHLILQRQTSESILHPHPLQHEHLCRWWTANLHQNALRKDTHDLGFMITPWAMKAWTLHRDPAAYNTLILAAHSLASRFNESTQCIRSWDQCITKRYAYRNSSQDFLFIIDNMLNLDLLFWAARETGCRRLYDIARAHAITTQKHHIRDDYTTFHVVDLDLETGEVKKKFTNQGYSDDSCWARGQAWGIMGFAQTFEWTREMRFLRTARALADVFLARLPDDGVPYWDFDAPVTDTSPRDTSAAMIAACGMLLLYKAYKKLHDVEAANHYLRAAMKLVDRTVVGYLNPPMQFEAGPASEISVYADQCSTHHTETRNGAEVLRVVGDVAETILTGATINNYEFAPRRWSDHGLVYADYYFLLFGNMLLEMDLVDPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWR0</accession>
    <name>A0A370PWR0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_101179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="853"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133478" checksum="06377427F0F0BC75" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWR8</accession>
    <name>A0A370PWR8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_273611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWR8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="374" mass="40323" checksum="E6E4AA3DBC16B2D9" modified="2018-11-07" version="1">MAAPRLFRPAARLLSSRLTSAPLRPQTACAPSILRFRGYATESGTKEVTVRDALNEALAEELESNKKTFILGEEVAQYNGAYKVTRGLLDRFGPKRVIDTPITEAGFCGLAVGAALAGLHPICEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVAPWSSEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSEAAQKDDFVLPIGKAKIERPGKDLTIVTLSRCVGQSLNAAAQLKQKYGVDAEVINLRSVKPLDVETIIQSLKKTGRIMCVESGFPMFGVSSEILALSMEYGFDYLTAPAVRVTGAEVPTPYAVGLENMSFPQEDTIVSQAAKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXG8</accession>
    <name>A0A370PXG8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_244917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXG8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="431" mass="47948" checksum="7F207680D9E0790B" modified="2018-11-07" version="1">MLYTQDISLVAYGVSLQNGFLPEVPPVRRLEDPYYSPWEEIAQDLPGLIQSGTIRRSVDDLGILSTKKLKGEPEWRRAYVVLAYLTHAYIWGGEKPKDVLPPCISRPFIEVSNHLELPPCATYAALNLWNFSVPSTDTDVTDPDNLSVVTSFTGTKDEEWFFVLSVAIEAKGAQLIELMLDAMHAANVDDSQRVISRLEQLNYGLKELGDLLERMYEKCAPPVFYHQLRPYLAGSKNMASAGLPNGVFYDVGEGRGEWHQYSGGSNAQSSLIQAFDIFLGVEHSATGETKPHGKSNPQVMTGFMQNMRNYMPGPHRRFLEMMLRTSNVRSYVLSHKPGSALRDAYNMAVMSLGGFRDKHVRMVTRYIIMAARTPPPNQVSSRTNLATTTSTIVDNSHEKLSAGVRGTGGTDLIPFLKQTRDTTKAAASYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXS1</accession>
    <name>A0A370PXS1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_332055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXS1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="63947" checksum="4638A135877F8F16" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY22</accession>
    <name>A0A370PY22_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_245236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="120"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="56094" checksum="7C86477C8798E379" modified="2018-11-07" version="1">MSTYTIVSGDSLWKISQDHGVTLDALRAANPQITNPDLIYPGQELNIPGPDRPPPESRSIPGDVPGQAPPPSSAPPVHLAVCPPGPPVVPGAAGAPPAIPPRPPMARPPPPWINAGRPGYKTFGYFTNWGVYGRNYQPQDIPAEYITHILYSFANIRPTGEVFLTDTYSDLEKHYPTDSWSEPGTNAYGCIKQLYLLKQQHRHLKTLLSIGGWTYSPNFAAPASTPRGRETFARSAVHLLADLGFDGIDIDWEYPADSSQAMDFVHLLRDVRRVLDEYSATHLGGKRLLLTIAAPCGPDNIQKLRIGDMDPYLDFWNLMCYDFSGSWDKCSGHMANVFHSGRGEITPFCADGAVTMYLRGGVRDARKLIFGLPLYGRAFEGTDGPGSGFQGVGEGSWENGVWDYKALPLQGSQEVVDGRLMASWCFDPAKRKMVSYDTPEVAGMKTEYIAGRRLGGAMWWELSGDHHVSHERSLVKGTAERLGRLGGLDGTENTLYYPLSRFENLRRGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY68</accession>
    <name>A0A370PY68_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="4">2.7.1.108</ecNumber>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_317047</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="4"/>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000444">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000028">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000004">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1373"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1435"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1475"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1533"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1573"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1613"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="17">
        <location>
            <begin position="138"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="833"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1693" mass="185041" checksum="5E6FC39AF083BDB6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY98</accession>
    <name>A0A370PY98_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit ribophorin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_272921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY98"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044332928" evidence="8">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="30807" checksum="53FA165BD68098F7" modified="2018-11-07" version="1">MQLWHSVLQLSLLASAAIPTAAASAWGFTDATVSVNTKGAGVGAGVKEVIPDNKALTKPVALGVADTLKVTLTAQEGRTGKHAHQVYLLLQDPETGLDISYPFNVKDNGKSRLDLTQKDLPIQFLSASEPLEARFLIGSFGESTAYNAAAFQLDVTRNADEPVPTVEVSRYGKLPEIHHIFKSDPQSPPIVITLAFVAMVLATLPVLGGVWLFLGVNVNHLPTALKSAPIPHVVFLGSLLSIEGIFFLYYTSWTLFQILPAVAVVGSVAFVSGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYI7</accession>
    <name>A0A370PYI7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_67493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="174" mass="19107" checksum="2F84C3A37719A71A" modified="2018-11-07" version="1">MELAAEDGRAQRDRSYLRILAPPPTFSVSVSGAELRAAARRSRFPFTLPFTPPPTAPCVLGCPWTALHLSFLHNTLFTRHSRRALARSQPQLLQLLIWVPILFFGPPLSPFFLLILLATTPSRCRQHGLYFTVSSSSLLPPQSLSALTPGTNTWFLASGSHRGLARADCGLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYS6</accession>
    <name>A0A370PYS6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_245671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYS6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="174"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="442"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1087" mass="123537" checksum="DAEA308C00800CC7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYY7</accession>
    <name>A0A370PYY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Localizes primarily to the nucleolus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="388" mass="43231" checksum="9221906415735B5B" modified="2018-11-07" version="1">MAAAVSQSEPSGSQNISALLETLTTCLNSTGSSLPKTKRDAPSDVSIEPPQDGISLLDTKSDLLLSYMQNLVFLVIFQLRGLKSSADKDAETNDSLPDDIVKKLVELRVYLDRGVRPLEGRLKYQVDKVIKAAEDAERAERGAAAPKKSKKAKKSARDEESGSDEGSSDSEGDSEEDDEDEDEEEDIDEMAFRPNVSAFSKKVEPEAKQDKATARATSDGIYRPPRIMPTALPTTETRERRERPQRRSNVIDEFVSAEMSSAPMAEPSIGSTIVRGGRQTKSKKDREREAERTRYEETNFVRLAKESKKDRAKRLRAEGPRGTFGGEEWRGLTEGADRITKLTRRAQGSGSALDRSRKRKNEDGQRDDGMGVGQIFEKRRKKVDSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ63</accession>
    <name>A0A370PZ63_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_206879</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="138"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="460"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK47482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="747" mass="82567" checksum="15BF5C4A83631AC8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF4</accession>
    <name>A0A370PZF4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_288055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="699" mass="78612" checksum="D91C9607333B4291" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZG6</accession>
    <name>A0A370PZG6_ASPPH</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016785769" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="190" mass="20017" checksum="21D67895253D95FC" modified="2018-11-07" version="1">MKLSYLFTLPFTATVAVATATPSKVLLPVKRDASSVVSAVNTISTQLVTLNTTVSSYPGGIEGTLSALQIQAETIQLEVDLKAAIKLTRLSANFTDTESQKVAEAFVTLEPQIASTLANIVSKKSDFDDGLLGIASLSFLVKFDLQELSILSKALGSAVQDKLSGTYADLAPLILNEISAAFKKAIAAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZK2</accession>
    <name>A0A370PZK2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="28913" checksum="E33232F56941865B" modified="2018-11-07" version="1">MSNDSGHHPTAPHSWATKPYTPRPRTLLIARPQNAAVSGVEIVSSTRSAPRLPTQPLMLQYRARRYHGVARQGHGAGCGGAAVDEDCREGGIQLQRLIQRLPDSDQANAHMAAAWKLSCSGMTTCSPARAITYSAKTPSVGCEGLQPWMTPNTRSPTRKGFVTAGADGFYDPCVVAAYCYAGAAAEGDFPVGGIEAYADGIHEDGVVPEGRDGAMTVIARTMVVIVIMQPTSRFSQDLLLLVKPEAGVLVISTNLIPEEDLEQLPSGWDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0M5</accession>
    <name>A0A370Q0M5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0M5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="173" mass="19389" checksum="2BE6912518B6C7E3" modified="2018-11-07" version="1">MEEGRKRYAPSPRQARQGQVSRERHTKPQTTQRLVKILPVRAPMISPARPRIPALTTKRGSLAGKLWDCHELCPGGSDRLISRSFLLGVRFSNLTSGDGGVCMYEVKGTTGYHPDDPERKDRQSYDRTCLVSRLCRNTRPLKPQSALIRPPGTADQTSLFSVMAEAWAPLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0P4</accession>
    <name>A0A370Q0P4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0P4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="46254" checksum="45DDC8ABE6FA69F9" modified="2018-11-07" version="1">MAPKKIIIDTDPGIDDILALLLAFSAEPEDVEVLLISLTFGNIEVKSCLRNVVSMFHILEREMKWRREQGRPEGFGTLRASPPIVAVGAENPLEGQTMLADYFHGTDGLGGIHASHPHLTPKEAWEHLFDPSPDSREIKPVPEGDPAHRSFIPSKRPAHEEILRILSENDPDTITLVAVGPLTNLALASAADPETFLRVKEVVVMGGAINKPGNVTPAAEFNAYADAVAAARVYALTSPSPRSTLPPATSLPEYPPSLSKQLTLRTFPLDITLRHGVTQGQFRQIITPLLEGGSPLAEWVAAFMAHTFRTLERLHPGHVGDAADLSLHDPVCVWYAMTAEDGGWKPSATSPEDIRIETTGQWTRGLCVVDRRNRHRIEADEESANDHGLWLSLRAGNRVWRMDSSPVEDTFGEVLLQRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0V7</accession>
    <name>A0A370Q0V7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_261375</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1180"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1225"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1256"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1429"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1541"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1571"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1596"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1626"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1726"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1764"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="158"/>
            <end position="226"/>
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            <begin position="1961"/>
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        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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    </feature>
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            <position position="1400"/>
        </location>
        <ligand>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003808"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
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            <dbReference type="EMBL" id="RDK48070.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2100" mass="237209" checksum="6FAC81FD121FB737" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
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                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35993" checksum="BE0E341AA913BFB6" modified="2018-11-07" version="1">MPGVLTQTLAVSDGPLTSENAALLRPSDPNLPLDELRARFDADGYLFLKQVLPREDVLEARRQYFSYLAPTGVLKTDSDPVHGIFNPDKTPDDFPGIGAGAAAGNGRPGGESAAEFVDRAIEAHYKDWYAEKLVRHPALYAFIAKFTGWGDNTLTFKRTLLRNNIPETKPIGVHYDQIFIRHGEPTAVTAWVPIGDIKLSGGGLIYLEDSDVVGQKIENEFTAKALAAGMTEEEAKYAFNSNMMSTGMLSENPAEFAKENGRRWLVAEYEAGDVVLHKPHMIHASTVNNDPDRVIRLATDLRFADSSRPYDKRWMNFYRFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
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                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
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                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="755" mass="83531" checksum="E9992B92D4FD0796" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P441</accession>
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    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P441"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712204" evidence="2">
        <location>
            <begin position="21"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="515" mass="56821" checksum="D7512E4D718E19F9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P443</accession>
    <name>A0A370P443_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_260270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P443"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="449" mass="49959" checksum="7AD3322B9DF5E4C7" modified="2018-11-07" version="1">MNTYKDTFHLPHIKGQPLHVLIVGAGIAGLSAALAIHKTGHRVTILERVREIAEVGAGIQMAPNAARILGRLGLLEKVMEKANALEMNSLRRYKNDEELGKAVLMPSVGEKYQAPLAVIHRGDLQSILLEAVRSENIPIRTDSRVVCAAPDFSARVQLHTGEWVSGDVVIGADGIKSDLRHQMAAHHGVKDICQPTGDAAYRIQIPEDKMKGDPRARELLKKNVGMRWMGPGGHIMAYPMKNNTVYNMVLLHPQKEGAETEESWTSKGDKREMEEFYSDWNGLVRDLLSYVPDGEVMEWTLNSHFPLPTWIENRVVLMGDACHPMLPYVAQGAAQAIEDAGVLGCVLALTDDIDSALAVYERVRKERAERIQKSAAVTRKALHLPDGEEQRKRDEAIRGPGKNPDLWADKSWQDFMWGTDVMKETVDNFDDLVARSHGYHPHALNAVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P446</accession>
    <name>A0A370P446_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_113145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P446"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477720" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="42"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="562" mass="61188" checksum="EDA5456A534A0566" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5D4</accession>
    <name>A0A370P5D4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_322071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5D4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016959657" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="391" mass="42389" checksum="0D4122E286FC1810" modified="2018-11-07" version="1">MYLSVVILLALSGIVTAHSSHDQTPLAGPHQRLWYNTLPGDGGTQADSVFSGISTFGRLPYFPCLSSEAERYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLQANPFVSDLRVLDCGDIPVTSYDNAWAIQQIEEGHNSVLMRKPFTDAEKYGLSKAGKTLPRIITLGGDHTITLPLLRSINRAYGPVTVIHFDSHLDSWKPKVFGGSPSQVAAINHGTYFYHAAMEGLLKNDTNIHAGIRTTLSGPSDYENDGYCGFEIVEAREIDTIGTDGIIKKIRERVGTENPVYLSIDIDTLDPAYAPATGTPETGGWSTRELRTIIRGLDGLNFIGADIVEVAPAYDTNAELSTMAAADVLYEVLTIMVKKGPLSVGRSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5H3</accession>
    <name>A0A370P5H3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_339886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5H3"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016571593" evidence="2">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="208" mass="23103" checksum="C6BC66C1380281FC" modified="2018-11-07" version="1">MNRSLFSIFIAVCVYAHYVFASLTSSEIANSLNELAQQGFAAKDLVLEINSTADAGPMRDVYTEMDTMVTVVLTDVEFMTNTPIITDQAEEQTVYEGYSNFVQSLLELMDAFSSSATELKSIDSTTKDKVPSEVRILESAVDAYFYNIIGLFPANSSYNAQASNQKAQVDTHCFQAIWAFDLSDGSQSTTQSRRNTSLHTRRMMRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R1</accession>
    <name>A0A370P5R1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_298599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="117" mass="13283" checksum="6DACC9B48F07CFBE" modified="2018-11-07" version="1">MLERRPMARSQFTPATPCNFISQEAGPMSRQIPRSEPPFRRVSPLSLSAATWPIKHFTWTSCDIFTLILGLAWTIVISLIEYCGSRCTRSSSNVTLSPKDAPVTFSSHDHQSMDYWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6D5</accession>
    <name>A0A370P6D5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_330467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6D5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="359" mass="39136" checksum="759175F3FAD0A6C9" modified="2018-11-07" version="1">MRFRTQIANASIFSKLTASLSSLGKVCWMRLEKDFIRFTIIPDQGTQVWAQLPIDTIFEEESYICESNTGAINLEVPIGALHRALRSAVSAKLANLRLTKKGNVPLLALTIRATSWTTTSNALDIPEATTTTDHSSSTIDNATATATARPSGTGPRERETVITQEIPIKVLHESAVEGLHQPRCRDPDVNILLPSLIQLKSISERFTKLATTSSNKTSTAAVGGSTSTTPSLSSPKLELSANMHGSLKVAVGTDAFRISSVWTDLLNPSLDPGQLGDGRELNQLPSERMREVPADDEAGWAKVRIDGKDWSRILSVGRLNPRVVASFIHETALVLYVFLPGSWNEQDSCLTYYITSYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P706</accession>
    <name>A0A370P706_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_88515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P706"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="96"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="211" mass="23287" checksum="B902784A939DEB29" modified="2018-11-07" version="1">MAIAVKMNGLSRCLGKQFTQFAKAPVFRKCDTIPFRLSGIPVRSYSDRSSKYNGNMTSQPPKNEMVYMPGVMSPNRSFGVFRKVLHTGLYSQFVAMEVPVNGEIGDEIHTVDQVLIFTHGTGKAIVAGKEQEVRQNDVVIVPAGTQHQFLNIGNTPLEVVTIYSPAEHDPRTVHQTKAEGDAQEEAGEDEAPEWSQRSKSENEKIGLVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7W1</accession>
    <name>A0A370P7W1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_307521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7W1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050583">
        <property type="entry name" value="Mycobacterial_A85_antigen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098">
        <property type="entry name" value="ENTEROCHELIN ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="312" mass="35163" checksum="A5EFF0F60D2091FB" modified="2018-11-07" version="1">MTVADKSDEVYPPIPAYGGRWTPPKHLLDCYNHMWIDTDVWELPENVIYELYSQPTRGPGAQGSYLVVLPPGYDDRDVNGERYPVLYWLHGGFSCSRHVMWSLQVYARKMELGTMPKVILVAPQSLPKGRWITSYDGSRRLGDIMRHDLVTAIDERYRTIRHPSARWLEGHSAGGYGAFNLGLKYPDVFGGALSSLAGSFRTELAKEGLEVTYDTYNGSQAFFTSNHALTLLKAILPRVHRDKPELRLLIGGEDIRLREAHEHMWTSLDALGVSYMKAIVPGAPHTAEHVLGGLNNEGLQFWWNARAKVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Z3</accession>
    <name>A0A370P7Z3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_307534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Z3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="40989" checksum="F9DAF8BB73F1B0CE" modified="2018-11-07" version="1">MTVQQPRPESNGSEDENSMRNVKTILVTGGAGFIGGWFVRHLLQVHGTRYTVLCFDILDYCASKRNFEPVEHLPNFHFFPGDLCDPDRVSAVFQQFKVDAIIHFAANSHVDQSLVNPLSFIQKNVTGTHVLLEAARQAGTVVRFIHVSTDEVYGGNLPGQDYAFTEEDRLNPTNPYSASKAAVEMIANAYRYSFHMPIIITRCNNVFGPCQYPEKLIPKFAMQILRSQRMTLHGGGEAVRGFVYVSDAMSAFDIILHQGLVSKTYNISSKEQITVIDVAKRIVRWFHAGQTDSCEQHLETVPDRPFNDRMYWTDDSKLRRLGWTEKVSFDEGLIMTLEWYRDHGETFWSGPGPACKLNGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P834</accession>
    <name>A0A370P834_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_269841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P834"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK38346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="166" mass="17828" checksum="5DAB289B49DB26A2" modified="2018-11-07" version="1">MALKPGDSFPSDVVFQYIPWSEDKGEITACGIPINYNASKEWADKKVVLFSVPGAFTPTCSINHVPGYIQNLPQLKEKGVQVVAVIASNDPFVMSAWGKANNVKGDDILFLTDPDARFSNNLGWASGGRTGRFAIVIDHGKVTYAQIETEKGAVKVSGADAILANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P898</accession>
    <name>A0A370P898_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_329958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P898"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016970111" evidence="2">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="199" mass="20192" checksum="2385BD8E4188903A" modified="2018-11-07" version="1">MKFALLPALLSTSVLGLNIGRAQATAQVTFIGAAGAQFTQDFPTDGSNVKITNPLSISHISCSTQGAVCTFDGIDHSVTTVTGVGQVDVGPPQTQTQGSCRFGSGSTSPSNPGQTHPTGGQVLITFVGAANAQFQQQFPTNGASTKISNPLSISHITSNTGGIHCTFNGIDNSVTTINGAQTVDVGPPQTQVSGTCRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8V7</accession>
    <name>A0A370P8V7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal Zn binuclear cluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_307270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8V7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="460" mass="51443" checksum="A88DC61AF348443B" modified="2018-11-07" version="1">MPPASLRTRNGCLSCRKRRKKCDESRPRCTACTRNSLECKWPSEGNQLPDGRSRQYKSIKAMVRAVAPPGVSLIQLPPPIMMPAPFSSSECTYLYRYFASTILPRFVRRNSLDKTHMLRLAPQFSPLFGAMVAVAGMQLPTKDRWPAHLALQSYLHAIHTIQMSLTDITKAACDDRILATVSLLACFEACARFPKSSCRSDATPTVAPHVTAAGLLLTQRRPCEFRTKAAATFDRICVESFLYQACLMMIFDPTLDALPDNREQLELPLYFDRPTRSDSTPGETVLQASYKFFLLIADVTKLSRLSRPLDSAEVAKWRSLNWELSRWSHLVCSADMSLALCYLALQILLHKVNPNITSSERVRRVHSCLAGGLQRVPALEIDIYPPVYLLWPMAILGSVAVRLEEREVFRDVVASISAAKLGGHAAWVQTRLDRVWRIIGSAPEDPEASLVGLQLLLDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P924</accession>
    <name>A0A370P924_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_239888</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P924"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="238"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK38673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="668" mass="75451" checksum="9A5305C31B691F8C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P961</accession>
    <name>A0A370P961_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_221605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P961"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="780" mass="88069" checksum="1E7E23B40C8955C7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Q4</accession>
    <name>A0A370P9Q4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_321053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Q4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="771" mass="86277" checksum="FD0B7C23D1FA6C2D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA59</accession>
    <name>A0A370PA59_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="427" mass="46942" checksum="960A8121BD6DE5F8" modified="2018-11-07" version="1">MTTKCRHAVEATALGTMVAYLIRNNPRRPSSTNANVLDTGLGGADGAVVVDMKHFTQFSMDDETYEAVIGPGTTLNDVDIELYNNGKRAMAHGVCPTIKTGGHFTIGGLGPTARQWGLALDHVEEVEVVLANSSIVRASNTQNQDVFFAVKGAAANFGIVTEFKVRTEPAPGLAVQYSYTFNLGSTAEKAQFVKDWQSFISAKNLTRQFYNNMVIFDGDIILEGLFFGSKEQYDALGLEDHFAPKNPGNILVLTDWLGMVGHALEDTILKLVGNTPTWFYAKSLGFRQDTLIPSAGIDEFFEYIANHTAGTPAWFVTLSLEGGAINDVAEDATAYAHRDVLFWVQLFMVNPLGPISDTTYEFTDGLYDVLARAVPESVGHAYLGCPDPRMEDAQQKYWRTNLPRLQELKEELDPKNTFHHPQGVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAD5</accession>
    <name>A0A370PAD5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAD5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="66" mass="7242" checksum="171D1B262453215E" modified="2018-11-07" version="1">MDTHPPKYATFPCLGMRVKGCMQKQGGYPTGREKKERKASFQGSAVDSEELGGHLTGEVADQLVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAJ9</accession>
    <name>A0A370PAJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="760" mass="85148" checksum="4CC9325C5871482C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM1</accession>
    <name>A0A370PAM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_238491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="56484" checksum="9DAFA874EF858915" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB15</accession>
    <name>A0A370PB15_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">3-methylcrotonyl-CoA carboxylase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_255821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="38"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="154"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="627"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="77602" checksum="10AADB147A941A76" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB29</accession>
    <name>A0A370PB29_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_56017</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04177">
        <property type="entry name" value="RSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041841">
        <property type="entry name" value="Rsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="211" mass="24272" checksum="28264AEC5CB070CA" modified="2018-11-07" version="1">MRPQREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQIDVDGRQCILEILDTAGTEQFTAMRELYMKQGQGFLLVFSITSMSSLNELSELREQIIRIKEDEKVPIVIVGNKSDLEEDRAVPRARAFALSQTWGNAPYYETSARRRANVNEVFIDLCRQIIRKDLQGNSKNSDSDRKREGGNRQDRRKDKKRQTRRKGPCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB64</accession>
    <name>A0A370PB64_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_320803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="12">
        <location>
            <begin position="343"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="812" mass="87895" checksum="230C16C576F92FDB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBF0</accession>
    <name>A0A370PBF0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_220707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK39508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.40.180:FF:000047">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
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    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
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    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1420"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1524"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1562"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1602"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1647" mass="184872" checksum="0CAE2E5FE9CDC211" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCC8</accession>
    <name>A0A370PCC8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="663" mass="76118" checksum="468D9F287E5F1F83" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCS4</accession>
    <name>A0A370PCS4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_328618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCS4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="250" mass="27945" checksum="1AEF43B2B68938F9" modified="2018-11-07" version="1">MSRFGAKKGRKLPGAEFTWEADPSGEPDTAPTPLFPKYTVPRARPLTSQEQLQVDFYRTLRERFHDGPYYSILEGAGSTMKKDSAARVNFDPFHGMPSYSGKYQKKKRALPRLQGRQYVMKFFPRELWQTIQPTFKPDAAMDGYVPQVARAGVKRGFEDDDEEEDEDAAKRAKAGGEEGEGGEDDDDGDGDILDPEEEQEGEEIEDDDFEDDDDEMGGDYNAEQYFDGGDDEYGDDGFGDGGGGGEEDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD55</accession>
    <name>A0A370PD55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_278019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="173" mass="19828" checksum="BE8FADCEED8D03A9" modified="2018-11-07" version="1">MRTSPNVIITGTPGVGKTVHCEQLAEETGLRHLSINHVAKERDCYETYDHELQTWVVDEDKLLDAIEDQVLQGGYLIDWHACDLFPKSWIDLVVVLRCPSTAVHYDRLASRGYNETKLQENLDAEIFGVLLDEAREAFDEELVVELNSERDEDVESNCARISSWVQSWKHDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDC1</accession>
    <name>A0A370PDC1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="210" mass="24523" checksum="13E40FF94F4359CA" modified="2018-11-07" version="1">MEATNGYNHEEWDTYYEWEPELAAFHQQAQDEQDLMLMHISERDICASVLFGKLIKIESLDRLCDIQSGLTDFDDSMHFLRQIDFYNVVAEPRAWRHQTAIDQLLVDLCSQLEVLVYIVDSAFEFSPVHAEQMILNDYVKWRWSLCRVMIDELKLRVEDLAMNFQRWARVTPGEYADIFPANPPDQEKEAKASEAPEVERLTQVGAVAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE08</accession>
    <name>A0A370PE08_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_337581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE08"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="189"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="405" mass="46790" checksum="24217C11C3CD470C" modified="2018-11-07" version="1">MGVDQHAQLDRFSLFLPFPYRVAVILLAGFWGWGVNLQYLLKANIDVPSLIKYPARQSSSQRPHYASTYQLSTLLTIPLAISLLIFWPATHGSAERVEAVEFIPQSYFFIGLFILILPFHRIARSGRYRFFMTLKRISLGGLAEAQDGKFGDILLADALTSYSRVFADLVVTFCMFFTTDVSSTSKPTRKCRTNDYVVPLIIAFPSIIRLRQCLIEYLRVRRATQRSQGAGSQGGQHLANALKYATAFPVIILAAKLKNYNPLDFYGYSEMSLSRLLFFFTFINSAYSFYWDITKDWDLTLFTPARRSHEHPYGLRRHRYFTNRQYYLAIIIDLAIRFSWLSRYVPGFVWMSETEFGIFVLMFSEVARRWMWVFLRVEAEWIRNSRGPAPDDILLGEFGGKLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE59</accession>
    <name>A0A370PE59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_237445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="759"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="881" mass="96599" checksum="1628C51910D32ED4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE91</accession>
    <name>A0A370PE91_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_44655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE91"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="450"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="628" mass="68226" checksum="917C50F49B78DA9A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEB7</accession>
    <name>A0A370PEB7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEB7"/>
    <dbReference type="SMR" id="A0A370PEB7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="40025" checksum="62BFB32926A9922F" modified="2018-11-07" version="1">MSEKLQSTLTTSLTLLEQFQGAIASPSSDISSSTDLSGKDALPLLSAASTTLKSQVTKLSLLTITSPFTPSAVTSVINALNESVLPSLVAAALLVTPAHHTKAFQSEVHVLTQTALKETTALLQEVQTVAKKAEDAQKKEAGLSQSEKDVVTVAAGRLWDSCDVLIDIAAKGVVGFVVRRVEEWRDLVRDAVQEIEEWDPNEEGDDFFDDLLSDDGKGKADEDDEEDEDDDDDEDTAALQEQKKSALRILKPVSQIYPTISANRLKKTSDSPSLVGKLESLMKYLQQIPGHVDEVAGALYEANTEKSLQYMRITKDCAVKAVNLASLPLDVTDSADAPQEKEDKFTTWARTWLKVMDQVSKSVIDATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEC8</accession>
    <name>A0A370PEC8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_33848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000011">
        <property type="entry name" value="Actin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000036">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK40540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="468" mass="51597" checksum="C7D42C4423D100C2" modified="2018-11-07" version="1">MGTTKPRPSGRASVAKVQSLPDKTFVIDNGAYTLKAGYAPDSAPPDDQSKALSACSEIPNAIVKTRGNKIYVGSQLNTHVTDWNEMMFRRPVEKGYIVNWEAQKEIWEHSFFDEKTVRSKDLRITDPEDTTLLLTEAPNALPALQKNADEIVMEEWGFGGYLRCVGPSMNAWNDVQSLFGDPIVQEANTTVSPKECLLVVDSGYSHTTVTPIYKGQSLQRAIRRLDLGGKHLTNYLKEMVSVRQYNMVDETYIMNEVKEAVCFVSNNFVGDMEQTWKGNRKRGLPDASEGVMVDYVLPDPNAGKKGFMRPHDALLNAKKRKGGLSGASAEALSEDALVLGNERFAVPEILFTPSDIGMKQAGIPDIIMQSLSVLPTGLHPAFLANVLVVGGNALLPGFVDRLESELRQLASAECAVRVKCPQDPIRSAWLGASRFATNKDELRKVAITRQEYQEHGSSWASRKFTGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEI0</accession>
    <name>A0A370PEI0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_277323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEI0"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="35428" checksum="5924CAEA5FE29691" modified="2018-11-07" version="1">MPFTHHSHSGQFCPGHAKDNLEEIIQLAISKKFHTFCLTEHMPRHEEDFYPEEIKAGDTESSHVANEAAYFAEATRLRTKYADQINILIGFEIDWIRPASRQLIEESLSRHPFEFFMGSVHHTLTVPIDYDRPLYEKARALAGGTDELLFEAYFDEQLDMLKQVKPVVVGHFDLIRLKSDDPDRSFQDYPRVWEKILRNLDYVAGYGGLLEVNSAALRKGMKEPYPNGEICKEFLARGGRFCLSDDSHGLEQVGLNFHRVVPFLEQVGVSRLHYLALGEGDAPVDARFPRTQIKEVTLEEVKNMSFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFN6</accession>
    <name>A0A370PFN6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_327785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="645" mass="72472" checksum="D991EC6A27890A91" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGD3</accession>
    <name>A0A370PGD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_277206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="35850" checksum="DA4216D6333ADF44" modified="2018-11-07" version="1">MPQMRAVVVEGGKGPADAMSIQEIPKPTPSVGQALIKVKAFGLNRMDLLQREGLYPLPPQAPETMGVEFSGTVESVAAGAESDFKVGDAVFGLAYGGAYAEFIVVDTGMLVHKPAELSWEQAACVPETWITASQALHIIGGFQAGRSVLWHAGASSVSICGIQLAKAEGAKAVYATAGSQEKCDFLVNELGVTAAFNYKTQDWAAEIKKITAGAGVDLIVDFVGANYFQGNLDAAARDGRIVILGLMSGQKLPNGVDIGPLLFKRLRVEGSTLRSRELEYQRKLRDSMVEHVLPRLKDGSFKVFVEKVFPFAKIVEAHKLLESNQTRGKLVCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGI7</accession>
    <name>A0A370PGI7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNARE domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46403" checksum="7CE396BF8AA02C5A" modified="2018-11-07" version="1">MRKRRPILIRLLKQMLTSSPRREALPFGFVADVLFQIIINGEVNTILTLCRLNRATYETIKVLEPHICGWFMRFHAIEFDPILTLNPWTGEQSTLTVHSLVRFFQRHNIAKDLSRHIVPSVWGPFCDDGNPEMDFEAELRLAKRLERGLHVLFHMADIARDTERLKPSRKPLAPVVSGRLFVLGKMLDEYDELPQHRKQLMSFEEYTNHVYTVLKWGYVEADIGRRRLEFRGWLDEQTEIDFHASLRMLRELMERMLLRHGPKDWHRDAKNEYSVISWFLLKQPPRSLAKLFLSPQNDCCDIDVKATDCGVRKCHFSDPLDNYWKAWKNVPDLGCQDCDCKRRVRSWSVKPALIDARGREFNRAAERYLREMWSQRHVGLHRAFTMGVFTTVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGX7</accession>
    <name>A0A370PGX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_276901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGX7"/>
    <dbReference type="SMR" id="A0A370PGX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000041">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000008">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000142">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016630721" description="Alpha-xylosidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="261"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="628"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="82593" checksum="0AA2256B6288F48A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH01</accession>
    <name>A0A370PH01_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin patch protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_27569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="327"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="808" mass="89667" checksum="AB410F5A515F6598" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH38</accession>
    <name>A0A370PH38_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_267506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="44423" checksum="C0F364915318EBCF" modified="2018-11-07" version="1">MVEKHELRGIASLPQEVYDEITLSFASDDLEVKVRNGRLMRLRLVSVPFDRSASRILFSAVCLDTSRLCKKAQLLHVQSPSSIKFVFTSDLCRFIRYLTVCLSSEIQQWNSRTVERTYENLSRCLIRLPSLQYFEIIPTICDNAHLQVDTMLRALRRAQRYLPRLVGLKISVPEILFQEPPPRLWRLEDVLRRYLPQLQHVDIDFGTWTYQDQDNHLDSTFLPLFCLGPGLRSIYLDGVGRSANHEYRSQELKPARWLHPDAPIEHIRLLRITAPYEVLAIIFRYKGRLVSLEIIDVVLSTGKWGEFFRKLREFPLLSHLVLCRCSYFGDKILNDEDKESRQSAYRVAEQRKKDLLPGKVRKIESRPLARIDKYDIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHC9</accession>
    <name>A0A370PHC9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_294450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45326" checksum="269DEA5E28829A42" modified="2018-11-07" version="1">MAILSRSAGSFGCPIPDHLEQHDVGPIVGNLTFYQFNMIVSGVCTAIVLFLILGLMGRHAMCMSNPNEQLKIMRICNLIPSYQVLSYISICFPNSYIYLQGFTEVLQGVALYAFLMLLCDYMAPDDTSKVKFFSSLETKRQWQPKKKRNGLAFLSLTWYSVLQYPIITWITAVTQVVTQSLHVYCLESNAPHFAHVWIEVITSLSTSVALNAIIQFYMNMKGYMTEHKPLLKLMAFKLIVGLIFLEKILFLILTGTKVLRYPASMTYIDTLMGLPTMLICLQMVPLSFLVLHAYRTKPYEIPNSVRGLRPQAYQALESDGNEETLLSGIPKHYQGGPWGLRAWTIYLNPLVLFQDVHSAYLMIHNARALQKVQEREEQEQEEMTRYETRYDPGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI28</accession>
    <name>A0A370PI28_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_20646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI28"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000163">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000282">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="86"/>
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        </location>
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    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="156"/>
            <end position="189"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="657"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="858" mass="93794" checksum="D94AB3E094C683E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI58</accession>
    <name>A0A370PI58_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_319436</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
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        <property type="entry name" value="EryCIII-like_C"/>
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        <property type="entry name" value="HIBADH-related_NP60_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="87920" checksum="64D02FA5136E8E66" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIC8</accession>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336325</name>
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    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="74"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="60394" checksum="96C72B7546226874" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIZ8</accession>
    <name>A0A370PIZ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_252600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1625" mass="184405" checksum="14678F5942057D8A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJB1</accession>
    <name>A0A370PJB1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJB1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="133" mass="14530" checksum="AED017B993E2C228" modified="2018-11-07" version="1">MPESIIIPSAHKPDAKSAKPTATFTGDVYLDPIHFDSDASIANVTFTPCARTHWHTHENGQMIKVVAGNGWICDKGGVPRRLNTGDVVWAPAGTTHWHGADEESVMTHFVVGLGKTVWHEAVTEEEYGLKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJC4</accession>
    <name>A0A370PJC4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_215030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802203" evidence="1">
        <location>
            <begin position="19"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="688" mass="76121" checksum="22986D828466E9C6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJG6</accession>
    <name>A0A370PJG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_300538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="37260" checksum="80655D438E6E49DF" modified="2018-11-07" version="1">MIIDITSRPDNQPKPPGLDYHRIRTLDAWIEQLMNCVTLSEDDIERLCNQAREVVQDESNVQPVSSPVTVCGDIHGQYHDLIELFRISGPCPDTNYLFMGDYVDRGYHSVESVSLLVALKVRYPKRITILRGNHESRQITQVYGFYDECLRKYGNARVWTLFTDLFDYLPLTALIDNRIFCLHGGLSPSIDTLDNIRSLDRVHEPPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISDAFNHNNGLSLVARAHQMVMDGYLWSHDRNLVTVFSAPNYCYRCGNQAAILEVDEQLNYQFIQFDPSPRTGEPTVYRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKP1</accession>
    <name>A0A370PKP1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_233557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="255"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="449" mass="46513" checksum="FD02DDDAEDD549F4" modified="2018-11-07" version="1">MASTSTTTAVEWQQGPPIELESRAPKNAVAPVSDPTDEVMEASRLADAEVPEGGAGWIVIAGCAVITWWFIGTSYCWGVLQAALVKDGVSSASTLSFVGSLAPACISFLGILNARVIRKLGTRTSALLGIFLLGLGEILSGFAVHEVGGLFVTSGVVMGLGTSISFMVVSITPAQYFKAKRGIANGIVYAAGGLGGAAISFILDALLSRVGTAWTFRILGFITMGTGLPAAFLVKQRIPIPPSAFVEWRLFRDIRFLLLFAAGAIATFPLLVPPFFLPLYTDSLGLGSAAGAGVVAAFNFSSALGRLTCGFASDTIGGLNTLFVSLLLSALSMLIIWPVSTSIGPLVVFVIINGMANGGFFSTIPTVVGNVFGSARVSVAMGMIVTSWAGGYLLGSPIAGYILDASGGEDAGIKAYRPAILYAGFMALGASILAAFIRLKTDTRLLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKS1</accession>
    <name>A0A370PKS1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_326543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKS1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="813" mass="91484" checksum="6B4D3B9CE27B405C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKX2</accession>
    <name>A0A370PKX2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_162677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKX2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="211" mass="25005" checksum="9BEB6A2439E61D3F" modified="2018-11-07" version="1">MTTFSLSEVSFVKQLKNSPVSCIFRTVWHGKDCILKVYHSPQPLSVKHRSRRRDRETDPFKCESAAFMRLREHGFCDRGHVPAFYGLIEHINPVHHLPYLQDFVEDTLYPNAILMEYVPDIHPIDLSNYSEKRLHKLQQILLEMHRAGVYHGDLYPRNLMVQITSDRVLWMDFDRAQTFTPQSIKECHLTWLERETRMMEEFVEGLVNSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKX8</accession>
    <name>A0A370PKX8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ent-kaurene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKX8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="960" mass="108059" checksum="EDB73750B390CD8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLE1</accession>
    <name>A0A370PLE1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_319068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="52322" checksum="ED6C4F116979C779" modified="2018-11-07" version="1">MNKEQSSEKHDDSSRTITTISLGHDSIVPSTDLSDKALSKNDPVDNGPVTSDTEQAQPLAPTEVDGGYGWVCVVCVFLVNAHTWGINSAYGVFLAHYLDTNTFPGASDLDYAFVGGLSLSMAQFIAPVATITTRVWGTRATLMIGITLQTAALLGASWAGQIWQLFLSQALCFGFGMGMQFSATVGIIPQWFTRRRSLANGIATAGSGIGGLIYSLATSAMIQNLGIGWAFRILAIVSAAACGFSAIILLKRPEFLLTLAWGCFSVLGYVALLFSIPDYASTVGLTASQGSILGAMFNLGGGLGRPVIGYVSDSFGRLNTALACTFLAGLFSLVIWIFAKNFGVLIFYALISGPVAATFTTTVAPVGAEVVGLQLLPSALSIFWLSVVIPSTFAEPIALWLRTDNETNFLHAQVFVGFMFMAACICLWLVRAWKVAELENAAPDSDPLKGEVQSRDNDAVLQGPVARTTSRVPSMTSKAKIVRRLFTMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLK4</accession>
    <name>A0A370PLK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_326783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="507"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="46"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="229"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115060" checksum="C05EFAFCFCBAF9B9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLL0</accession>
    <name>A0A370PLL0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_166471</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000681">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="79"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="262"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="51527" checksum="DDAE283D1158A484" modified="2018-11-07" version="1">MPGVKKRKVAREAPAPAPAQESDVESSTPEQTQEPEAQEQEQEEGQSKTFKELGIIEQLCEACETMGYKAPTPIQRESIPLALQGRDLIGLAETGSGKTAAFALPILQALMEKPQPFFSLILAPTRELAYQISKSFESLGASMGVRSCVIVGGMDMVSQSISLGKKPHIIVATPGRLLDHLENTKGFSLRNLKYLVMDEADRLLDMDFGPLLDKILKVLPRERRTFLFSATMSSKVESLQRASLSNPLRVSVSTSKYQTVSTLLQSYLFIPQKHKDLYLVYLLNEFAGQSTIIFTRTVNETQRLAFLLRALGFGAIPLHGQLSQSARLGALGKFRARSRNILVATDVAARGLDIPSVDVVLNFDLPGDSPSYVHRVGRTARAGKSGLAISFVAQYDVEVWLRIEGALGKKLKEYDCPKDEVMVLGENVAEAQRQAIMDMKDYNEKKGSRGKKFGGKRSRDEMDQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLR2</accession>
    <name>A0A370PLR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_293301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLR2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12906" checksum="F73AE905FADCB92B" modified="2018-11-07" version="1">MRATFALRSAARTPLIRFLGRRSVPQSVDHTPRPHPASPSGILPDSFAAYRIKAQQHGPLGRASFSQGIGRSSGASLGPVQPKQGEFFDRDELPARFHRLPWSEAEIEAIETGGASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM04</accession>
    <name>A0A370PM04_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="134" mass="14602" checksum="D2DE4378E4697C99" modified="2018-11-07" version="1">MTTEIKELSLPLPYTPHTTAHIHLTRHQTCTTVFLTSSTPGDAAGSIKPMGSFVYAMPDRMDPKNVISTTIYSVPGSVEYTARIAKILARRLKTPVYVGGSIEPATMGVMAEEEIEGVKRLVEVIVKGWEGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMH0</accession>
    <name>A0A370PMH0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_314591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="601"/>
            <end position="637"/>
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        <source>
            <dbReference type="EMBL" id="RDK43390.1"/>
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    <sequence length="972" mass="110625" checksum="049874B733C2456B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN15</accession>
    <name>A0A370PN15_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">M752DRAFT_250410</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="32"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="1188"/>
            <end position="1214"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1225" mass="131920" checksum="A2EF51175B2BDEF6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN62</accession>
    <name>A0A370PN62_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_318850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GPI_mannosylTrfase"/>
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    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017034482" description="Mannosyltransferase" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="567" mass="63133" checksum="24B2C27E70127BD9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPD4</accession>
    <name>A0A370PPD4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_264943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="769"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="851"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="969"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1256"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1615" mass="175866" checksum="1E90617C37E90E73" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ30</accession>
    <name>A0A370PQ30_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_137967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ30"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29475" checksum="23B15CC0EA08EA24" modified="2018-11-07" version="1">MASAVLPACATPYRSSYSHRYHPNLMDMDVEMDSYGSYQRFLSSSPSRRSLNRQRSTSFPSVYYSGSPEHHPVEPRRRKESSTSQYSSRRHRHGSPSNPQPARYSRNSMLVNPDVIDRLDSASLCQYHHEGPYDAVYAERNYHTKQSPVEAVKNSTAETLKATPKDKIRDCIDSHRPLDGVAYYPPGHTDMEGRTYEYEEGPNMMNDYGNFMRCPGQKFTDEDFKKDPFYNTPHPKPFASLRKALSIRRRKRSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQA4</accession>
    <name>A0A370PQA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_264280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="157" mass="17104" checksum="FEA80669BBF67B3F" modified="2018-11-07" version="1">MQYTVASESYSAKASFPQQTCAKGPNPLETMTLQIRVIVSKTAPYELSKPFLCAFRVLFGSTVDLATIRYYLNGSLDLHPTGGCLTSETNRYKSGGLGSLVLRGTSGNVQWKTAAVVAVQQAAVSEKYCYCPGRLGHPKTSSYFNNHIHSGYDTECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQP6</accession>
    <name>A0A370PQP6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_140322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="85" mass="9779" checksum="2B491FF13E154851" modified="2018-11-07" version="1">MIRSIMMITEEKKWGRTSQCVCVCRLLFAFWVDLIRRKAAWSICLIHALLFSGSMCLFVMLSCKSRQGKASLLASPLFLVYFSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQU1</accession>
    <name>A0A370PQU1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery associated TMA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_334425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="68" mass="7457" checksum="98145C3B9FF412CF" modified="2018-11-07" version="1">MGGQSREGGKVKPLKSAKKEKKELDEDDLAYQAKKRAEEKAKKELMEKAKGKGPLNTGNQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQY1</accession>
    <name>A0A370PQY1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_334447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQY1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="481" mass="52439" checksum="5CE969DB4FB2431D" modified="2018-11-07" version="1">MASLPGYSASSRPQSSDNNTTSTTQQNSVSTNITSSASSTESFETSDTVLLNGTSDTATARGSPTSPTLADASGEEPRRCWICYTDETEDSPLNSQWRSPCPCALTAHEACLLDWLADLENPRSRRRNGHDAKMLCPQCKTEIIVSRPRSYIVDVVRLVERLAGRMVLPGMVFTLGATVWAGCCAHGVYSMYFVFGTDEARQILEETADGAWNSGLNLGLPLIPLVLIFSRTRYADGLLPAIPVMFFATHQPGQELELDLWPPSAAVTFAALPYLKSFYGSIYERMFGKLERRWIAEVQPRQSDVNEFDDNAPPEHPEPDPPNDDNGVLMEIDLELRMGNEDGPQGLFGFNGGNAQGGQGQNQGGNGQPLGLGRRDELVADTSSLADIILGALAFPAISASMGGLLKYLLPTSWTTPSTLGKVRPGLLQTRWGRSVVGGCAFVLLKDALVLYCRWKLAQTHRRRKVLNYDRSKKRVGKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR09</accession>
    <name>A0A370PR09_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular thaumatin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR09"/>
    <dbReference type="SMR" id="A0A370PR09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF7">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016736838" description="Extracellular thaumatin domain protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19034" checksum="2D09CFC9554A27C8" modified="2018-11-07" version="1">MFFKTILTAALATAATALPHSVNNNMVRRNGTSSGSGGVSISNNMSNTTVYAWSVSDRVSNMHTLSAGGGSYSESWQTNDNGGGISIKLSTTESQSDVLQFEYTQDGDTIYWDMSCINLGSDSAFTKYGFSVTPSEEGDNCPSVNCEAGDTACAEAYLQPDDNEATHGCPIDTQFTLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRF7</accession>
    <name>A0A370PRF7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_282051</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRF7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="13"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="102"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="316"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="47119" checksum="45F2868B42B7B143" modified="2018-11-07" version="1">MATEISKIKVKNPVVELDGDEMTRIIWQEIREKPTKTLLPSFLDVDLKYYDLGLEYRDQTDDQVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIIIPTIPRLVPGWNKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGEPETVQVYDFQGGGVAQTQYNTDESIRGFAHASFQMALLKGLPLYMSTKNTILKRYDGRFKDIFQEIYESTYQKDFEAKNLWYEHRLIDDMVAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLVTPTGEAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLVQRGKLDETPDVVTFAEELERACIDVVNEEGIMTKDLALACGRKEREAWVTTREYLAAVERRLKANLKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRZ0</accession>
    <name>A0A370PRZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Retinoblastoma-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_129947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRZ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="608" mass="66557" checksum="C2B3E27AC4013762" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSI8</accession>
    <name>A0A370PSI8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_325096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSI8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK45153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="227" mass="24672" checksum="485850892D72F82A" modified="2018-11-07" version="1">MFSRSLRSTITPPCSPFASRPLFSIPNCKQSSFLSLRPFHQSSAAMSGNTKAFFDIQYAPVGSSAPKTGRVVFNLFEKDVPKTAKNFRELCKLPQGQGYKGSTFHRVIPQFMLQGGDFTRHNGTGGRSIYGEKFADENFIYKHNKPGLLSMANAGPNTPQAANSICSNGSQFFITTVVTSWLDGKHVVFGEVADAESMQVVKEIEALGSSSGSVRSAVKPTIVDCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT47</accession>
    <name>A0A370PT47_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_324331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="43937" checksum="7AF213E70843F375" modified="2018-11-07" version="1">MSPLPAYTADSSPPSYDEVAGKLDGLLGTNPTVEKALEAARSLSDEEINVLANGYEDRKPLQTDQQKADFAVGAGQHLSSEEGQNGMAQAGTAASQASFDIDKRLIDIQQKLAVIDQRYNEGFADTIAGIRQDYNQVLQNSRNLAADISQNGKSFDKIIIKYCADSDIGIEDRKAKVKTFISNTNGFEATAKDIQEQYSNVKSKFSSFVETYSTWAEDKEGELTQQIADLEEEIRSLTQELNSIEAAQKVMAALAGAAIPIAGALGTIFEPVKPLILIGGLIFAGVALAASIGLLIAAERVKNKINQKTFEKEDLEQLLENIRSARQDLQGMQQSGLLSFQACLDVLPQYWNSTVQNAESIHDWLEKGAETTARPMYMNLNVEKGVASYNSTAVYLDNYARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT50</accession>
    <name>A0A370PT50_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_118472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT50"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000299">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477375" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="58547" checksum="DD49E62A0A81D0CE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTA5</accession>
    <name>A0A370PTA5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_290265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTA5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="38560" checksum="71DA05D5FBA3E97C" modified="2018-11-07" version="1">MAFESLAFHTKLRILRWLTRLLAWLDRKRHPVSTITPTSQISIPSTLSASPGNFDLHIYHPPGYNQSSTKKGEALYPVVIVLHGGGWCVGHARHDERFIETVTQRGRAVVVAVNYRLAPEHAYPVPLLDCVDAMLYIWKNATAMGVDKHRTFITGFSVGGQMAFASQYWLAQAIAQHEHPQIDRASLGTVKAITAFYPPMDLTKTRAQRAASNPAFMALKKKPASSSKLIGDIFDRAYFWNLPDTIDKSQICISPGLAPLEMMSRALPNHIYVKLAGLDPLLAEGKAAAAQFEAAGKHVECEVVENVPHYWDHLGKTEHEKTLRSRVYERAADEMEEVLRNVNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTZ5</accession>
    <name>A0A370PTZ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016894179" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31598" checksum="F72FF12236816C8D" modified="2018-11-07" version="1">MIALSWLNFTLTTTPFPVTVATACVTPGAVTQSSAIIFRCNASDPIVNQYTAQGNEACVDNSLASNVSIPLLADMNALGSVFIRSNGLPSTAGYFRSVRKPLILDSKCNAVTISNADCGYWHTIQMNETCDTVTEMFGNSCSNLWQGNSFCVQAVGNIDTYFGYPMTSRTAYITLPQSSILTQMSLPTVLQRKNTLFELLCLRYLDDLQVAASSKPGLRQATATARLTASKSSVSAINSANTMTTSKITQSSEATSMAFSSVNTSPDGIRGESTGYSCTNSAAKLATGGLNQGLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV47</accession>
    <name>A0A370PV47_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_323838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="748" mass="83501" checksum="E0E00AE9996F10AF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV49</accession>
    <name>A0A370PV49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_332703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="310" mass="33490" checksum="9928F58C671F9CC0" modified="2018-11-07" version="1">MFDVQGNYALVAGGSKGLGREISLALVKRGAHVTVIARSQDALDRIKVDMEAVRVHGDQVIGIQNLDLSNSEEVFRFVQTFGNEITALFCTAGGTDEEVGHFVDIPATSIQSCMEKNYLTAAFVAQAVMRTWTTELKRVGECDGAQKSRHIVFTASTAALVAVPGYAAYSPSKAAIRALADSLRQESLMYPPAGAIQVHCSFPGTIYTDSFYREQARKPQLCKEIEGTVDDGGGLTAKEVAQRVLVGLDSGCYFIPTDLQTRLLLNNMRGPSPRDYPILDWCMGSAASLVWPIIGTYLDWKVARSGGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVG5</accession>
    <name>A0A370PVG5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_281954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="27435" checksum="78B4D6EC4B25B39B" modified="2018-11-07" version="1">MSPAIPVIDFRPREDRQRLTDEIHHTCEDLGFFQLRNYTIPVELQTAILEQSKDFFCLPVEIKEKYDRGKLASNIHTAQKLEKRTTGDLKEGFSLGRHLPLDRRPRPPDASELERGVHYQSSRIRLPTTNELTLLAGIGAHSDFGAITILLQDSVGGSTDFLVECLESCLEPGRYLWGCHQNPNIPTIARTDHRDLGELFHRDMEGKQWIDSKRHAASAGSTRTTLKMNPDCSCGLPSAQGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVM5</accession>
    <name>A0A370PVM5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_273334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVM5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="418" mass="44161" checksum="0342D79681B8924D" modified="2018-11-07" version="1">MASNIPASLRSADIGRYALRAAQLERAKPVVAYWCNFWIVNQIIGRGLHTSDDDVKQYTTDLVDKLEQFKSENVDNDAVTDAVAANAYVEQFGLEVLGRAEATMKANKVTKQTADTFQAAATFLELCQIWTNPPEPEIAAKIKFCKYHAVRIIKAIKAGEDPNASNPAPTEEDELESELRGMEAKQDDPEVQAIVGSSAAPPGQPSVEEVPDESTQPSQSPLSLPQPPTTFADAPAAHYGADPMSTSNMEDDAETGAPLNLPSAPETFTSPAPSVPNLPDTPADIGAKAPQARADSFHSFPPPSSIPPSSPSAASHDASSFYTRPTSGVAPPPPFVQSSSATAPVVSRPTPQSIPSSTPPPPAPAASSSSGVNAQSLDDQAIALAQKHARWAVSALTFDDVNTAIKELKNSLRYLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW07</accession>
    <name>A0A370PW07_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A-oxoamine synthase fum8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_332699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="117"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="874" mass="96257" checksum="B0310BB1744FA6A2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW99</accession>
    <name>A0A370PW99_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_333040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW99"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
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            <end position="286"/>
        </location>
    </feature>
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            <begin position="292"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="372"/>
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        </location>
    </feature>
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            <end position="418"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="541" mass="57636" checksum="9960D853468E387C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK4</accession>
    <name>A0A370PWK4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653916" evidence="1">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="28919" checksum="ABB4BD607F2A7223" modified="2018-11-07" version="1">MGKTLISLLSFPLPLDALGLGRLIHDRKNPRQGFFDPTTDLPTKPKPDVSASDIHSFADMVKSTHAVELEASLTRFASAFLRTKAKSFDELKSCLVKEYILSNADSWYDTIISEGATRRWIERSKMRGKDVYLVTGYRTLLDATLSTSSSSGVHGGGTAHGPMGALIGNPDDSLDIKGKAQVDSAKSHNLSMLVPGERVFALQYLKIKFKPFSSDKVDSSYLASRNRWIETLTVRGEEAENDGLEAVLVEDFDDDDDICYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK6</accession>
    <name>A0A370PWK6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_310094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK6"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="339" mass="37139" checksum="ABE65A0A5F718D10" modified="2018-11-07" version="1">METLTQRQTVHKVAITAHHEGVKAQTQPPVTNEMPIQGVAKLVPSSWVPYVQLMRLDRPGFLGFFMPTLMGLSAGATLANPPIGPLDFFKSFLFFWFVTNFIRGAACTWNDNLDQDFDRQVPRTRCRPIARGAVSTTQGHIFTLAQVAITAWILSHLPAQCHAYSLAMGVLHAIYPLCKRFMDFTPVFLGLPFSVTMILPAVGMGVDPFSGPAACLFMVEFIWTIIYETIYAHQDVQHDVQAGVKSMAVRYRHSTKIIASVLGVVMVGLMVAVGVLAGLSGIYFLVGCGGTALSLVVMIYSVDLTKPASCLYWFRMGFYIVGGSKSAGFLAQYLVDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM7</accession>
    <name>A0A370PWM7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_104165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16539" checksum="8C8B10A0DAF6CF38" modified="2018-11-07" version="1">MSHRLFILVYRGDPLDYSEYRHTALYVQFASQKRSILHILGTQGLYRYVEYPEADPMELGDLVRAVPVADLSASVEEDEIRETVARTPVRNGYLDLEWNCQHWVGDALARLVDRSWVAGTERADAIDKMTDACLEAHDDQLLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWU1</accession>
    <name>A0A370PWU1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_101684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="117" mass="13011" checksum="FBD7803180B2EE9C" modified="2018-11-07" version="1">MVQSLSRSILAPTTSSSHPPALHVESPHLQTNGHTSLLAFFLPFLSFLFLEFRFSLFFSLRSVLPYFSFLHVQLTINTVCLSVVSALRPTDELPHPAILTKTSPSVLRLPHSGSFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWZ4</accession>
    <name>A0A370PWZ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
            <ecNumber evidence="4 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_208042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWZ4"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF57">
        <property type="entry name" value="PECTINESTERASE 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477377" description="Pectinesterase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="43"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="327" mass="34613" checksum="FDF6C1B7B7F00B6A" modified="2018-11-07" version="1">MHTSYLLGALAALAATAVGAPAEHIKKRESRTSAPSGCLTVGSDGTYSTIGDALDALGSSTSSACIYVASGTYEEQLTIDYAGNLTLYGETTDTSTYKDNVVTITHTISSSDAGSLDKSATVNVVSDGFSMYNINVENGYGEGAQAVALVGNADQLGFYGCQFSGYQDTLYVKAGTQYYSNCMIEGAVDYIFGDASVWFGECDIVSNGAGAITASSRETSSDSGWYAIDNCNIKAASGVSLTEEVYLGRPWRVLARVIYQNSVLSDIINPKGWTTMADGATPLYYEYNNSGAGSDTSDREYETSISAAVDKTTVLGETWGDWIDRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX52</accession>
    <name>A0A370PX52_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium bile acid transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_244790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="48050" checksum="93A7ACFE299BF51A" modified="2018-11-07" version="1">MSIPNHDPTSTRGITQTFKTIALFILHQWLLIGIGVACVLAYYFPNVAKSGGIIRSEYSILYGAMALIFLISGLSVPREKLIIHLLNWRLHVLVQGLSFLVIPAFILAIVHIILAGDPDEHIDRALLAGYIFLACIPTTIASNVVMTRSAGGDDAAALVEVIIANFLGPFITAGWTVTLLPKSSEFDVWRSGDGDLSDMYRDVFKQLGLAVLLPLVVGQLIRWVWPDIVGKVLAKYRIAKISTACLILLVWSTFSSCFATGALQTLSASSIVFVVLFNIALYMFLTAVCFYCSRPPRIISGVSFTVKGKTFYPFQQMNPQETIAVCFCGPAKSTALGIPLLYAMWGPLSLYIKSKTSVPVLLYTTEQICVAHFFVHMFKWWHRRVERKSASVSDVECDGEGNANENEEKLDGSGSDGRNLDNQSKGADVSLSQEHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXW9</accession>
    <name>A0A370PXW9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_323475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="126"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="448" mass="49160" checksum="13548B8C80B09559" modified="2018-11-07" version="1">MPVAGSKVLLLGSGFVTKPTVEVLSKADVNVTVACRTLESAQKLCEGFKNTKAISLDVTDDAALDKALEQVDLAISLIPYTFHANIIKSAIRTKKHVVTTSYVSPAMMELDEECKKAGITVMNEIGLDPGIDHLYAVKTISEVHAEGGKITSFLSYCGGLPAPECSNNPLGYKFSWSSRGVLLALRNAAKFYKDGQEFSVAGPDLMATAKPYFIYPGFAFVAYPNRDSCPYRERYNIPEAQTVVRGTLRYQGFPEMIKVLVDIGFLSDEGREYLNTPIAWKEATKQILGATSSAEKDLEWAIASKTAFANNDDRDRIISGLRWIGLFSDEQITPRGNPLDTLCATLEKKMQYEEGERDLVMLQHKFEIEHKDGQKETRTSTLCEYGVPGGYSAMAKTVGVPCGVAVKLVLDGTINQKGVVAPMTMDICAPLIKTLKEDYGIEMIEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY09</accession>
    <name>A0A370PY09_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_69607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50708" checksum="8225BFE3AF5CE8B3" modified="2018-11-07" version="1">MNFNVRQVQTHLFRLTISTASFCFLLFLYISFEWSPSASDPSGFSASSYEDDLDAAIPAISACNGFNPATVADVLDATLTAKLPINGSAVDDFVCSIMTHDMNLSAKLDCPATISPRYADLPVRASNSFFSKPKIKYFFALDLYQSAHIMLPLMGTIVETMRFLGPEYCALSIVEGRSTDGTYDILNRLKSEMAAMGVRYYLSTSDLNPKAIWADRIKHLSTLRNQALAPLVSAGAGKFKPYAADATILFINDVVLCVEDLLELLYQHRQQDARMTCAFDWNAAGGPFYDSWVSRSMSGNLFFEITHDARYWLTQDMFFDDQPNQQRYARKLPVQVYSCWGGMVILDAAPFVQRKLEFRNHKEGECHMGEPTLLAKDMWGQGLGKILAVPSVNVAYEYKATREAKDGQGYVHNVIESADYKAGKELVVWDKEPPVRIKCMPLFNQQSWVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY28</accession>
    <name>A0A370PY28_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol acyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_306130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY28"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF61">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="11">
        <location>
            <begin position="373"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="856" mass="96422" checksum="4EDDC0DC84F1F784" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYE7</accession>
    <name>A0A370PYE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_306595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="396" mass="43102" checksum="BE7AD99A6D998BD8" modified="2018-11-07" version="1">MDQYPLGGLSTGPGKSAFVVTIISMVLVTICVGLRVWLSIINPRPFGFMGYFYYAGYIVAMAYSAQFLWGICPNAIGMHIMTAMTLYPDRVVNALKIVLASEFIWAIATTLVKFSILSLYLEIFRGKLFRASCYTIGALSLALAAAMFLIAGLLCQPIEKNWDPLMTTGHCGDSVKMDVATATINMILDLFIVILPLPSLWKLQMSWTRKAMLSGIFSLGLVICAMNLTRIVFAVTLDMTDATHAIARIGLFSILEVNVGMICASLPTLGPLIFGDHRGGSSGGRKGTPDPRSSAAIMNTFVRRRAAGLGRSDGGSGRFSEIATLNDNTVFDEEALPLHQVEKSGKVCEMEDHHDAMMAPSPSPDQTLPRRPETARLSCPDGQGKDINIRTDIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYP9</accession>
    <name>A0A370PYP9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_273021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016481296" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="29624" checksum="B04C3E4FA91F6723" modified="2018-11-07" version="1">MNFKNIFLSFFFVLAVGLALVHAEDAQPRGPKITSKVFFDIEHGDKPLGRVVLGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKDFMIQGGDFTRGDGTGGKSIYGEKFADENFKLRHTRKGLLSMANAGKDTNGSQFFITTVPTPWLDGRHVVFGEVLEGYEIVAQIENVPKGRSDRPVETVKIVKSGELESEDKAGEKETSSEEESQPSAIAVIPSPTPLPMTSDNAPYIFPKFAALAIVVGLLVVLVRRSLKGEQEKAERSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYW9</accession>
    <name>A0A370PYW9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_260764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="484" mass="51728" checksum="6052698DDFC1B38C" modified="2018-11-07" version="1">MTPQTIVIGTGLAGLTTTSTLLTHHIPVLLLDRASKPGGNSIKASSGINAAPTRYQLEPDTISTFQYDTILSAGVPYTSASGVERTRREKLIDTLTTKSADALYWLTDDIGVDLSRVARLGGHSVSRTHRGAGKGTPGYEIIKGLLGRVSEDRNCRMEVGRRVTRILREGGEGRVVGVEYTVTDGEEGGNQTKTETAYGPVVVASGGFAGDARGLLAQYRPDLEGIPSTNEQREGTQPLLQEVGAAVVDMEQVQVHPTGFVGGKEEEAEAMVKILAAEALRGEGGILVLGDGRRFVNELETREKVTGEVMGQAKKLPTKARQWDVKLVLDEGAAAALQSHLGFYMWKGLIKKTTVGELEEMSALKGTLREYADVVAGKKQDEFGRQSFGNWTLREVKPESVVYVGKVTPVVHFTMGGVVINERSQVLDGQGQPIPGLYAAGEITGGLHGQNRLGGSSLLECAVFGRIAGEEAAAYYQGLKETCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ74</accession>
    <name>A0A370PZ74_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">60S ribosomal protein L7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_322565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ74"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="348"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="488" mass="53730" checksum="9A9FEA950DB25DD8" modified="2018-11-07" version="1">MINAVLVFNNNGQPRLTKFYTQIDTQTKQSLIAQIYNLVSQRPASACNFLPLPPLLSRGASSGAENGPSDAPTQITYRNYATLSFIMISTSMESPLALIDLIQVFVEALDRMFENVCELDLIFGYETMHAVLSEMIVGGVVVETNIDKIVSAVRDQEGNLGKKKAIQAASSGIGRTGLPGLGAWRGIVLLWLPEHEFGVSSGFLLLSFPLTVNPAPNAAADPVDKMPAQKSGKKTAPLPYPQGKAGAKKAPKNPLIEKRPRNFGIGQDIQPKRNLGRFVKWPEYVRLQRQKKILNLRLKVPPSIAQFQNTLDRNTAAQTFKFLNKYRPETKVEKKERLHAEATAVAEGKKKEDVSKKPYNVKYGLNHVVGLVENKKASLVLIAHDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHKKTSAVLALTEVRSEDKAEFAKLLSAVKEGYSDKYEESRRHWGGGIMGAKAVARQEKKRKAVEGAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ84</accession>
    <name>A0A370PZ84_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="83" mass="9534" checksum="F14113781B6CEEE8" modified="2018-11-07" version="1">MPNKCIGRESGCLWYLYDGNIRRRFSKNLTNCFCCRLGLFSFVPLRFSGGLHGYIFVLFYIIHCMLGIACIPHFLLFQSGSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZM9</accession>
    <name>A0A370PZM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_72997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="100" mass="10971" checksum="D878D93545EAC7DD" modified="2018-11-07" version="1">MPPFEFLALQISFAAGAACITAVTLKEKARCSRWPAQLQRCPPGPNSSLKRMFKYQCCIIIADDLNIICVSCLLLSILLSSTSSAWAYQPLFSSSPPFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0M4</accession>
    <name>A0A370Q0M4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_8660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0M4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12697" checksum="6542CCD3DFE69A08" modified="2018-11-07" version="1">MIGFLLSAKVNDSNKGRTRAADRMYRKEKKAKSTAACACMGPWPSGWALLFSHFCILFYFFYLPGMTSSGALSSRNRVITVVANRWRKQRMGQIGFHCWRLAKREYFSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q162</accession>
    <name>A0A370Q162_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_12197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF4">
        <property type="entry name" value="PITSLRE SERINE_THREONINE-PROTEIN KINASE CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="792"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2219" mass="247974" checksum="D5D53BC2F6FB16F2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1E0</accession>
    <name>A0A370Q1E0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine decarboxylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_316770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="RDK48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25091" checksum="A2A50D63BCDCA9EA" modified="2018-11-07" version="1">MATQEAKPAVVCVFCGSYPGNSTSHLEAARALAQDFHKHNVQLVYGGGTVGIMGELAKTLVALSGPKSVQGIIPQALVDVEEGYKASASDTQSKEGKAAERIVDQSVQESNFGMVTIVPDMHTRKRLMAQKVLEGGPGSGFVALAGGFGTMEELMEMTTWNQLGIHKAGIVLLNINGYWNGILQWIQTAVKEGLVSPENARIIAEATKAEEVLKMLREYQISSDRMALNWGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q2D8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="51412" checksum="E02B32B5D069BFE0" modified="2018-11-07" version="1">MAAVDHPASSLPHLQLLSDLTPPSLERTWLTAPHPRLPIVATCSSDKTVRVYSLTNFRLLSTISGGHKRSVRTAAWKPHVQGESVLATGSFDATAGIWRRWDSYGQTTGDEGWGLGQETTTNKSESQEEQAQETDILRQQQATHNENDGADDEDEEWRFAVLLDGHDSEVKSVSWSPSGMLLATCSRDKSIWIWEDLDDGDNNFETVAVMQEHEGDVKCVAWHPVEECLASASYDDTIRIWREDLDDWGQVACLRGHEGTVWFVDWESVENAPVCLEEALLAQWKENVKRELSGPRIVSCSDDRTVRVWRRQPKEQAAAGGTGMPSILRPTGLDETWEEETVLPKVHDLAVYAVAWSKRTGLLASVGADGRIVIYEERLVLVDDASAGDSQPMDTDPPAAAAKGVVRTEWVILAVLPGAHGIYEINHVAWANRADRDRDVSKEEEVLVTTADDGSVKVWSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3T8</accession>
    <name>A0A370P3T8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_311064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3T8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="705" mass="77520" checksum="1781DF890A981988" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3W0</accession>
    <name>A0A370P3W0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_331087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3W0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110:SF1">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="38054" checksum="43380AA8276C77E1" modified="2018-11-07" version="1">MTVPSNPSLSDSAPGYVVTHRGSVVENRHQVHAAVTDATGRILYAVGDPTRVTLARSAAKPAQALAVVETGALEKFDFNEADLALMCASHSSEDRHLSRARAMLSKVSMQEEDLRCGGHAALSEAVNRAWIKQDWTPTAIANNCSGKHAGMLAGAKALGATTAEYHCPTHPLQQQVAHAVEELAGLSSDRVQWAIDGCNLPAPALPLQHLAAIYARIANAADAVASDDLSPRTQALGRIFRAMVGHPELVGGDGRFCTALVQAFEGALIGKVGADGCYAIGVRASDYTQRLGSSGALGIAVKIEDGNRGILYAAVVEILRQLQIGSPVQLQPLVTFHKPEIRNTAGVVTGHTSHQFQMGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3W2</accession>
    <name>A0A370P3W2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_340369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3W2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016670992" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="13585" checksum="0118F44149D2EEDD" modified="2018-11-07" version="1">MHFLLLLFLGLLQLVSAARSGTYYAGWPVGDSTWKTTDSVFQRETGIARYRLFQADGIIYKYQLDFDVTERQGEYASTYVFYDSEGDEYYKVVFATGTHTLNYNSGDPYIQQVKVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Z4</accession>
    <name>A0A370P3Z4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_114237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Z4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="37491" checksum="B38E17B8E5DAE53F" modified="2018-11-07" version="1">MAPSTMKAIQIQQFNEPYHVSEVAVPQPKPHQVLVCVKAAGFCHTDLMALNNEFGTQLPFIGSHEPAGIIEEVGSRVTEFQKGDRVGCINFDSVCGKCPDCKAGRPIYCDAPMMKGITADGAWAEYMVADARFMIKLPDDMEFKVAAPLMCAGISIYGGIVRANVPQGGSIGIVGIGGLGHIGTQVAKCMGYKVAAIDVKQSALDAVASYEHKPDVSILATDPVEKSQEKINKAVPGDYPGLDATVLATDHPSAFELAAALTRKHGKMVLLGQPEKGITMSYQTTIYKNITLVGSLIADTADAQAFIQLFHENKLHVEVKEWKLEQAEQMRQEYLAGKSNGKNVIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P459</accession>
    <name>A0A370P459_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_331072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P459"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="360" mass="38629" checksum="9AFA087F9CECAF10" modified="2018-11-07" version="1">MAASDYKFEGWMGLDKNSVGNMVWQEFEPKPWEESDVDIKVTHCGICGSDLHTLRSGWGPTMYPCCVGHEIVGVAVRVGSEAEGDIKVGDRVGVGAQSDSCRGRNGDCEECASGLEQYCRHSMVGTYNGVYQNGGKSYGGYSLYHRSPSRFVVKIPDAIPSAQAAPMLCGGITVYSPLRHYGCAPGKRVGIIGVGGLGHFGIMFAKALGADKVVAISRKNNKKEDALKLGADAYIATDDDADWAKNNARSLDLIVSTVSSSKMPMVDYATLLDLDGCFVQVGAPEDGALEIPAFALIGKRAKLGGSLIGGPNEIREMLALAAEKKVQPWIEERSMKDANKAVVEMDAGKARYRYVLSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P466</accession>
    <name>A0A370P466_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_310842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P466"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016605908" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46190" checksum="3D68C7885D782C65" modified="2018-11-07" version="1">MSPAMSIASPFCTLPPELLLLISACLDCSALCSFRLTCKAIYDCSFPRFCKYLENITTDLSLTSLQKLDTLSRNQRLCPFIQTLNIDGTEQDIIGSGLTWEHHRSGLLVIPQESIQRWQNVLLRLANCQKFRLYKWETPVEPDPFDRTTPNDTITILLSIVIAIERPIRELSILFKRPNIISVDQLDLSRVHNSLLHDPKFITTCCSSLETLTFRFKVEEEDEANFVVHLIHHSKPHLKRLIIDFSFGECSAPLIFDLSLMIRPPLRLQELDLICGCVDSDQDLIRFLFSSKQTLVKIHFSSFKIDFGGWPAIFRTLSEFSSLTEISVSQLSGYTTRGRYGTLYFRELLWDPIVDPVLGTKFSYMVESRTGRTTVKVAYSGRSMNIALQKLAEYAAFWYGENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4R2</accession>
    <name>A0A370P4R2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_280036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4R2"/>
    <dbReference type="SMR" id="A0A370P4R2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="171"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="380" mass="42529" checksum="8B1E748A1B335D20" modified="2018-11-07" version="1">MSAPSDSPAPAPAVDTSQTTPSDPSPSNPAEIAATPETTTKPAESTEQAKEIDEFESQLPLSAADGLIQKPFPRPLESAKPTPPAELTSDQQAKYKDVLKAVSEWTTVPTTSAKNSPTEPITDNERMFLTRECLLRYLRATKWNVSEAIARLQRTLTWRREYGVEKLTADYISVENETGKQVILGYDIHGRPCLYLLPSNQNTETSDRQIQHLVFMLERVIDLMGPDQETLALIVNYKETKSGQNASIGQAKQTLNFLQNHYPERMGRALVINMPFMILGFFKIITPFIDPLTRQKLKFNEDLGQHVPPGQLMKSMGGEVEFRYDHSIYWPTLNKLADQRRAAYKERWIQGGKRVGEIENYLKTGTSPSLSQTEGANGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5I0</accession>
    <name>A0A370P5I0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_279875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5I0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="153" mass="17304" checksum="B6B878158F23FEEE" modified="2018-11-07" version="1">MGNKCPRTFDISSVGWNQGPCTIGRSGSLMIFQNRNPASLNCSWSLIIEGDSKHTTGDAVSTTWQLPVRGSFDCLCTDRQKSDEYVVARPYQSNHLDMWTNFVIFKHPERAIASSIASSSVLRWDEWPRGDSDSAQNTWRGRWVVWSCRRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P611</accession>
    <name>A0A370P611_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P611"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF468">
        <property type="entry name" value="THIOREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="11648" checksum="0AEC9E643C1BFE54" modified="2018-11-07" version="1">MDQLNSKQEINDAIANHASFILMFTAVWSDVGNITKEKFESIGAKYPTVYMAWVSTDDHLELAKEWGFTAIPATVGYKNGAKVETFVGPQYLDEQVEAFIKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P694</accession>
    <name>A0A370P694_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_270757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P694"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39618" checksum="4A89B910CBCDED54" modified="2018-11-07" version="1">MASSSRYQLADILKINPAADHHCLGLSHSYNRRCNNLISYQKRQEAHSLIERGSRVFAATSSISAVDPLLVDIASLLLCPNQHRYQFLTLVAQWEAKLQRYLAEQRSGAPIAVMSNSYFHMPPNPTIMATGSGIAVTNLTTTHHGPGSSSRITIQHGMVGMGANHHHHVQSPRPRVEIIRPAGDPVAATTSISASASSSASPSPHANSAFHHRPQTPAVQLVSSTLIASGHTHPAHQGSPRPLPSGPNTISMYCDSPTAPKHHRVKPRPVDGDCGICLLPYLDESMRCDMSDDGRTDDDEDDEWEELDDEELAGPDYDHGLLVWCRGSCGTNYHRACLEQWLDTFDTLEPTCPTCRNYWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P698</accession>
    <name>A0A370P698_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_298279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P698"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="519" mass="56362" checksum="4F0BF9AB7232AB7B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6A6</accession>
    <name>A0A370P6A6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_330440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6A6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="53725" checksum="D85DD111FBC3D33A" modified="2018-11-07" version="1">MGWVYNLTVPDPHSHVSRVIAICLVFSITACLAVFLRLYIRIHTKRSAWLDDFAALWSALLAMTYAGIAVAQTRWGLGLDARYFPDQNVVMFSKIQYAGGPVYTLALLGFKVSLLSSYLRIGGFVQAYRVTIIVAIVAVTCNQLVFTFLLCFACNPVARQWDTSLPGSCIDTVASYYALAGTSLGFDIIIIALPLPVLLTLQLRLRQKIALVGVFALGFFITIIQIIRIFTIKNLKTYTDSQPIVIWSDVEISLGVIITCIPTYGPFFHAFASTLSSSYNNNRTYTTNNTYNNPHNTYATLTYLTSPTTTTSTSYPLRKTQTRNTTASSIVTSGGRKKSRDLVDASLDEVARGLGMDGLGLESGMLFGTSASEEGRSVRSRSRSRSRGSRREERSCSPGGGGGYGGVWDGSGVAPTTTTICSLPAVARVREGRFAGDGLGGDEDMLEAGYGGGGFGVSAVGGGSSSSMITGSAGASGNANGNGNGSGWRIQKIMEVRVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6T8</accession>
    <name>A0A370P6T8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_258595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6T8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="54903" checksum="A2E9D1716EDEEE52" modified="2018-11-07" version="1">MASPQIQHEGLRAIFTGIERVSEGVTVNEFRGIKYASVPARFERAQPVDGFGDAVVDASSYGPRCPQVDVDVRHLLRIPEDFPIEKEPEDEFECLNLDITCPPASSAKGPLPVLLWIYGGSQVVTFCSAASKICDPVKIVADSIKSGQPIIFVSINYRLNIFSFGDGKEKNLAIKDQKLGIEWVRNNIAAFGGDPNNITLAGESAGAVYTHAHLVTGTPVKRAVLASGSLYLSSPLPVEKGQGLINALEAKVQELGEPSLRLASVPALLQALRECNVNTMWIQEDEDFQGWETKSELVDELMIGDTEYESVIWRNGIETFDGEAITAAFEQNEKWGPKLRKMYQVVADRPTACKLGALDLVNDVRYTLPVGVVAEKLQAAGKRVYKYVVDQANPWQASSRAHHAVDLLFLFDGVDLSFNPAAQAVGQEMRSRWVQFVNGGSPWSTEQRFAYGPLGSCGEISEAQFASRRRVEHVKVLREAGMGVYMPIVFALTAGKISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P796</accession>
    <name>A0A370P796_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_298051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P796"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="998" mass="110776" checksum="D8DF49DA14F9CF3C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7D6</accession>
    <name>A0A370P7D6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_257491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7D6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="30200" checksum="322E32B2B9B8BBB9" modified="2018-11-07" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKANSPLIDPPSLSKISLITPDIGMVYAGMGPDYRVLVDRARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLIAGWDEGVEPESGEAQRGDGEDEPKKATGKTGGILKGGPSLYQVDPSGSYYPWKATAIGRHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIEIGIVGPPADHLLGYEGVEGSRGPRFRKLSKEEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7G2</accession>
    <name>A0A370P7G2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_339091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7G2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="382"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="595" mass="66469" checksum="22EC53A2AEC39AD1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7K3</accession>
    <name>A0A370P7K3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_81812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7K3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="129"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="799" mass="93625" checksum="EC5F4FD7E0F3C158" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P823</accession>
    <name>A0A370P823_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_297293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P823"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="476" mass="52588" checksum="23C04C4A7468DF9C" modified="2018-11-07" version="1">MADDDTVKGLAVEAESSRTDDTELTPQEQRRVIRRVDARLIVMLGFLHTVSLIDRGNLSTAAVAGMEKELHLQGNQYNVIAVVFFPPYICLQMLGPVLIRKLGPKLFLAGICFIWGVSMMCGGFVHNWAQLAGIRIIIGALEAGFFPAAVYLIATWYTRYQMQKRFAIFYLLGCVASAFTGILSYGITFMNGLGGLTAWRWIFVIQGLITCTLAAISYFVLINFPDRMRSSKSRFLSHREYDFITDQINADRGDVRLEPFNLKKYLVAALDINIWGFGLVYFCTTTTAYSIAYFLPLIYREGMGFSMGASLCLFAPPYVAAGITMFATSWIGDKYRIRGPIIVFNAMLALIGLPLMTFTKGNGPRLVGCFLTTMGANSNVPAAMAYQANNVRGQWKRAACSAIFVGLGASGGMVGSLVFRSQDAPEYRPGMLTCIGMQAAAIVLVGLLTIRLYLRNCRVDRGELVIGDLPGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P867</accession>
    <name>A0A370P867_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P867"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="47914" checksum="3A5D95847C94C7B7" modified="2018-11-07" version="1">MTVSNNDKPLRIAIVGGGIAGVTLLLALLKHTSRQNIAPHLYEATPEFSEIGAGIAFGSNSIRAMELIDSGLAAAYNQHATFQPDTGALDKKLWSSYRMGMDGRGPPSNSLKAGDYLHEVHAPVARSSVHRARFLEAMTALLPPEGGFVSFGKRLVSIEEGADGATVHFADGTSVVADAVLGCDGIKSRVRQILLEGEEAANAVFTGKYAYRGLIPMDEAVAALGEYTARNNHFHWGYGGHLLTFPIEHGRTMNVVAFRTKDNGVWEHGSQWVLPGNKKQMLQDFEGWGPDVRAILSLMRNADIWAMFEHAPASTYHRGGRICLVGDAAHASTPHQGAGAGMAVEDVFVLSRLLGAVREKNDLVRAFVAYDAVRRPRTQELVRTSRDAGMLYECQKEGVWDNVDKIRENLDMRMRWIWDLDVEQHLQDALDIFHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P880</accession>
    <name>A0A370P880_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_297346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P880"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="227" mass="24978" checksum="178169DAB2590293" modified="2018-11-07" version="1">MTAIAMGDKYPYERLDKDKALLLIVDLQEGLYSTVRDADPTAFKNNMLAHAAIGPLFNLPAVLTTSAQTGPNGPLPREILDMYPNSTIIKRPGEVDAWDNEDFRKAVRATGRTQILLASIMTDVCTCHLALSLRAEGYSVWANAEASGTSSTLVRDISNERMRHAGVQIVSLFSMVCDLMRDWRNVPGGKQMIPYLDKYFPVWGMIARNHEAAVLNGAVQAGEHGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8A3</accession>
    <name>A0A370P8A3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Striatin Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_78594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8A3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="829" mass="89809" checksum="C38A55776617AEB9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8D8</accession>
    <name>A0A370P8D8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_78894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8D8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="197" mass="21513" checksum="C270A7AFF87F9735" modified="2018-11-07" version="1">MFVFRFSKPLGASEEGREGRTREKENGVREKLKNKRRQQRKINGALTRVEEDKGKRAKREKETSCHYLGWISSAQGFLTAEQREREGEKRMGGVRGKGGKTRNEQVAGGGPGGGTPKESHSLGGGAAAAAAAYCCLLLLGGKRKKGKGKGTPAKTARREKSRQHRDRLVGSGLVWSFSPCSSANPHPKGREKREGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8S8</accession>
    <name>A0A370P8S8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_307186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8S8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF557">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C1039.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="93"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="38047" checksum="E70410009880F456" modified="2018-11-07" version="1">MSHEALNPIHPSVLPHLDPTFIELYNKHVANTPSGPIDLTVLRSKYSVLYSYGTGPAPEPARVYDATIPGHNGDLIPCRVYEPDSPGPWPVHVDFHGGGWGLGDLDTESHICKHIAVKAKVAVVDVAYRLVPEHAFPIGIQDSFAALQHLASPAGRAQFPSLGTTRISLGGVSAGGNIALILAHLARDHQLPLRLVAVGTPVIDDISVYTTAHDSPFPSMQEMEHAPTLNWARLKWFDQLKWRSLSEDENVRQKQMAEVKWYANALKAPDFTRLPRTVIYTAGCDPLRDEGEAYARKLVEGGCEVTVRRFEGVPHPFMHMDKDLWQARQFIDLIAGHIKVALHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8U0</accession>
    <name>A0A370P8U0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_307247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8U0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF94">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="entry name" value="MFS"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="330"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="57271" checksum="CF7A219616A5107A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P958</accession>
    <name>A0A370P958_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_321208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P958"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="37617" checksum="F44C007B4F394CE1" modified="2018-11-07" version="1">MAAPYGISLTDRSGVIVIAATLFMSWMVLVSLFRVYMRVAMNGPAGWDDVVVWIGGAIGIGNVGAIMKSVSQGLGRIDPSDEEGAMKALYTADLLFLASHGASKLSVCLLLRRLGREGAYIRLCTVGLGVLVLWVLASILAVALQCEPSKPWNLTQCRSFITGWRAMAAFDVITEALLVGLSIRLVWGVQMRRTQKVGVIGAFGTRILIVALIILRQRYLNRVGLNNLLLGMSNVVVTTEVLLHSSLMAATVPCLKPFVIAFNTGWGQGGQKDGSYLRSETSEGPPSKARSRPYPADDEIIMIPPAGTREGEGNLEEASGGLVIHETREWSLRTEYIEMQPLKGSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9N9</accession>
    <name>A0A370P9N9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9N9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="37"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="33412" checksum="B83507F1476FBFD5" modified="2018-11-07" version="1">MKSVMRLFCRTENSTDHDIESEGVMESEKIEDIPAGYPRFSTFMSSHPSFQLYRRFSSLRTRDILMKQDRLAVLEEKLHNLDRNEENPSFLASCRRDRNINRQEVLSDIDRALCEYDDAITRNSHILKLEHARTRPVSALQNWITGNPCIARSETEFLQHEDDLMTLFSLEDGTTTYLEGWVEDNLIRLFSRSYKNRCETLSRDPMVYIPRDNVVVHIARGLLGLLAIMFIIGPVIMCNYLESMLSRLIVITASTTCFIGFLLIGTRAKTVEVLVAGAAYATVLTVFITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM8</accession>
    <name>A0A370PAM8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_338157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="244" mass="27622" checksum="8B68254D82E827D3" modified="2018-11-07" version="1">MFSPIIRVSIRLHSSLLSSPLSFAPSRVNSQLTFPPQHHNIPSCPPLEQRSYSESSDDSMQSAFGYFDNTMYTMAATDLPMTQPSFEPSSYESTSFTSSVNSSPFNAYYNFTPSLMYSPEAYTFLQTQTPPVPVSGGEWIAPQSTTPSTEVVYSPEETCDALDNSRPVKPFSCRDCGKAFTRPADLKRHHTSVHNPVFQDCPVQECLRKDGNGFPRRDHLIEHLRSFHHWDVPKRRTTKRSRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAT2</accession>
    <name>A0A370PAT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_329016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="380" mass="42979" checksum="8EF33D6454FC98FC" modified="2018-11-07" version="1">MEALAREVRRLVEAGDEKTRKDVLDALQKLSVSIETPDDTVQRLTFYNMQLAGIRIGIDLKLFELLLEGPLTVDELSQKTGANPVFLARLLRYLASYYAVEEVSKDTFTASGISKTFAVSGHQAAVGHMWNNCGQIIQILPSWLKENNYPDIQDNVKTPFQKALNTDVPAFIYMQQNPEALGYFVEHMMANRAGMPTFLDAYPVLEKATGLSPERALFVDIGGGLGHQAISFKQRYPQLEGRVIVQDLAQTLAHAIEFPGVEKQVYDFFTPQVVKGAKFYYLRNIFHDWPDHKVLEIIKNTIKAMAPDSFLLIDEMVLPNTEVHWQQAQLDMLMMATLGARERTEEQWYRLAEEAGLSINKVYTYTVSLRDSIIEAVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAW1</accession>
    <name>A0A370PAW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_296372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="371" mass="42726" checksum="4D6A8A47C92FCCDE" modified="2018-11-07" version="1">MGSEDIHEREKEIVASVRPPHQRRLSPFVIAGRAEEKQLGISTRRLNVNDFALLKTLGTGTFARVWLVKLNDERQRKNRVYALKILRKADVIKLKQVEHVRNERKTLADVSGHPFITTLIASFSDDQNLYMLLDYCPGGEIFSYLRRARRFNENTSKFYAAEIALTIEFLHDVEGVVYRDLKPENILLDAEGHIKLVDFGFAKQVGDHETYTLCGTPEYLAPEVIHNSGHGLAVDWWALGILIYEFLVGQPPFWDQNPMRIYEQIVEGHIRYPQNMSPAAQNIISLLCKTNPTERLGYISGGSARVKTHPFFEDINWDDLFYRRIKGPIIPRVDHPADTGNFEEYPDPDVKNQSLYTDDLRDKYEALFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB22</accession>
    <name>A0A370PB22_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_238716</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="271"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK39388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="431" mass="47042" checksum="7EB4005D74D1504E" modified="2018-11-07" version="1">MATLQRLPFFVRQSSRTLARCRKPLIQPPALRTLVMKHPKDFVPPTEEDLLELRERVQEFTRREIPEEVAAQTDAKNEFPAEMWKKLGEAGFLGITANEEYGGLGMGYQAHCVVMEEISRASGSIALSYAAHSQLCVNQLSLNGTPEQKERFLPGLLSGEKVGALAMSEHSAGSDVVSMKTTANAVDGGFLLNGTKMWITNGPDADYIVVYAKTEPEKASKGITAFVVEKTFKGFSCARKLDKLGMRGSNTGELVFEDVFVPKENVLGEVNRGVKVLMEGLDLERLVLSAGPLGIMQAALDLVLPYTHVRKQFGMPIAHNQLIQGKLADMYTKLAASRAYTYATARQIDNSAAEGSGALIRTQDCAGAILYAAERATECALDAIQLMGGNGYINEIPAGRLLRDAKLYEIGAGTSEIRRMVIGRAFNREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBL4</accession>
    <name>A0A370PBL4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_337933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="21916" checksum="F0EAC595606ED7C8" modified="2018-11-07" version="1">MQSHHQQPPQPPKQAPYNQASNPVTHTPSEQRIPQNQSSSQTQYDRLPRHRGDALPAITRNAASQPSNSQDQSTKHQAYQQTMRNAGETLDTEYGVEQQPAEGDIAHAVQSKSADARARAQAGAHAGAVGSAEGPGAPGYEKGEMADLDQKREMHDRMLGDRVGQSPAEPEGETEAVRRRKLRQDEEVDVVGAASRGSAGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBT6</accession>
    <name>A0A370PBT6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_255388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBT6"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016978241" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="67"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="28034" checksum="4280C0464E2CEFE9" modified="2018-11-07" version="1">MVSFLGQARLAVPILSAFACMLAASSAIPPPPRGALSPERLQWIREVIGNQTENDSVSDLAKRSTILHTSQDGVDSAGFYYSVYNDNGADVGYTEYPTTGQFELGWSTETEFLAGKGFKGGNPRSLTWDGYFTAEGDWTLAIYGWTTNPVTEWYIVESHGTGTPGNGNILGQVDSDGGVYDVYNLPYRNVPEIYGVTNFDQHWSVRRSHRSTGTVDVSAHFQRWKELGLNPGSPVFQMVTLEGFSGQGYLDFTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW5</accession>
    <name>A0A370PBW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_320625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="711"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119893" checksum="49523C9CDD75B7DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCL8</accession>
    <name>A0A370PCL8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_320423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK39938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="488" mass="52613" checksum="9D0401CACDAE4053" modified="2018-11-07" version="1">MPPPVGRYGPTGLTASYTHLQQAHLQQQQQAQHHPAHAQSANSALPPPSLGGHPGFAAGNPNTNINPFTLSGTGIANGMSVAGFASAGDGGGTGLASHAAQMGFARGAQMQQQQLHQTHDGRLALEAKAGAVKTRIRDVWSHNLAQEMAILRQFVEKYPYISMDTEFPGIVARPMGAFTNKADYHYQTLRCNVDLLKMIQLGITLFSAEGEVPPPNATDANGQPLGNSLVPAPCTWQFNFRFSLEEDMYAQESTAMLAKAGIDFSMHEKNGIDPFEFGALLISSGLVLLEDVHWVSFHSGYDFGYLMKIMLCKPLPENEEEFHKLLKIFFPSLYDIKYLMKHAGRNQAVNDSPLTPAAAQILTNLGQKSGLQDIADELGVKRVGIAHQAGSDSLVTGEIYWKMRQLVFNGSIDESKYSGQIWGLNGQMPALLYHMQPHQTPNLNGATIYSATGTPSTPNAGHLGSQTPHTLTPGATGGALGQFQLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCR3</accession>
    <name>A0A370PCR3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">beta-glucosidase</fullName>
            <ecNumber evidence="12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_237753</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="12"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCR3"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000119">
        <property type="entry name" value="Probable beta-glucosidase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="13">
        <location>
            <begin position="395"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="839" mass="92160" checksum="A7403295CEFDCDB2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDB3</accession>
    <name>A0A370PDB3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63227" checksum="9A640C56DB1317DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDD1</accession>
    <name>A0A370PDD1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_268007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDD1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="176" mass="20221" checksum="301CB2F3005C06C9" modified="2018-11-07" version="1">MGRTYRTHHPKFAPGRTVNLRSFRRSLPFQRDDEGNITGYDQLLNDSRKNVEHYDSSGALYANATEALQGDRFYVEQGDNGFRFKETETGKYLALKGHWIGLDDEGTDLWFEEWPKEEGRYIITPRGDNIYPDDGPGYHLWFEGAPDAVFRNGDDDLNVKGEGQHAIFWIDTLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDP3</accession>
    <name>A0A370PDP3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_295487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDP3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="29677" checksum="96674DC5DBCDD93C" modified="2018-11-07" version="1">MSFPYKKVLIIGATSGIGKALAAKVIENGTQLVIAGRRKENLDEFVQQYGSDKVASKVFDVMQLDQIPQFATEITTAHPDLDCIFINSGIQRPFDFSKPNSVDLTTFDTELITNYTSAVYLTKAFLPHLQSLPTQTALAYTTSQMALVPMMRCPNYGASKAALHHFILALRTQVAEGPGNVKVLEIYPPAVQTELHDPKHQPDLKNGHLIGMPLDEFVGEVWRRLQSGEDQIAVGSANDIYEAFETKRQSLYADMTAMLNGLLKQFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDP4</accession>
    <name>A0A370PDP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_277630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="480" mass="53637" checksum="673B904C6373F653" modified="2018-11-07" version="1">MSGSDPMEPEAAEESQVDESEADVVEAEGARAQGSAEEAAAEAEYDSEDEEPEDLPHDLELFRRSLEHTLSNNVLTVKNFAQVICTICRDHRVPVKHLPRLNFYNALRARLAPLLDQLMYNPRAHNNNQGTTISEAIFKNKVRPIQVLCDLGFRINDIMHSNLTLLGAAILRQQSKIAQYLLNPEFKEKYGVDPFRPVTLDTRFADGITPISLCVNRYEHKVLKTILSYGTPPNVMRTEDVNQLFRSQLWAHVSPIVHDQYFRNAIFAARNPPISPIHCAVVNSDLLVLRNLVWVRADQPNILPNLAFHINAENNVIIPNATPLLVALHRQNAVALTILLRTPGIDPSRPNSRTLTPLYYAARIANLELARILIEHRADPRVVTAMGTPLHALVHTYREAKERRMASENPQEWALLKENLAQLQLLFLESGVDPEARPDGADAMGRTASEEAELVAYWEFLNVLVAFRNAAAAPAPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE33</accession>
    <name>A0A370PE33_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_268236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="35066" checksum="56E4C535FF6887FB" modified="2018-11-07" version="1">MGNDGGSIPTRRELVREAARNPSTAQVKEAQREQQEHSWTTCPISHNQLMRPIVSDSVGNLYNKDAILRFLLPGDEADGISSKADCEEILCGRVKGLRDVVELKFEVDTEREAHPANGKQDKREGWICPVTAKQLGPNVKSVYLVPCGHVFSEEAIRQLKGDKCLQCDEPYTPDNVIPILPTKEADKQQLIERGHKLAEQGLTHSLKKAPGSKKRKKNAANGDAADAGKEPKPTEKSTSATASRSNTSTPTPGGSSGIKNAATALLTARVLEEENEKKKRRKMLGTSDNISSLFTKETKDGHAKNTDFMTRGYSLPAAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEH0</accession>
    <name>A0A370PEH0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_295020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="38817" checksum="415E638E731EA395" modified="2018-11-07" version="1">MFWGKHHDDTPEAAQQPPIPRKKLPSHLQTLADHDDGFYDDIYSSYSVDSTETPYRYAGYANRLRTVLLSAHRYVAYTSDIGESFRPVAHPWLVRSAYAISWTYLIGDVAHEGYKAYLRNRRVLAPPCEAYKDASDLTHDKIAKGMVTGNIAGSLTGGDTLMPWPTTHVPLAEDYRTVMAQRAVFQGIASMGLPAFTIHSVVKYSGRMLKNSRSVFFRTWAPIGLGLSVVPFLPYLFDKPVEEAVEWAFHTGLRAYAGEDAVRPLPQAVRTPHDEDTSLSHFLKLQAEKNNGEVMGHDANLSWEQYKEDRRRAKEQRMQEREQRGEAGPLALLGFGSNSKEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEQ5</accession>
    <name>A0A370PEQ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-alanine--D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_295105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="103"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="312" mass="34710" checksum="9DB79000F6CE54B4" modified="2018-11-07" version="1">MATESLKIALIYELREAYKALGYSNADCDRFEVGEAAEHIAAALKNLGHEVVLVPDIHSLVKRLAHGEAREGQVPALLEAYQIPFTFSDAATMTLCLDKGRTKMVLEHFNVPTAPFAVIHFDHTAEKTQVSLDEILSMIRMSRHSETLLSQYPLFSIESLCDVVNSLRDSSPSSLGVLVEKYLPGREFTVGILGTGEDAWVVGVDEIYADDWAGEADEIKIGWDDQEADLACQTALRAWTVLRCRDGGRIDIRMDHSGSPVAHVMEINPLAGLLPHWSQLPMIAEHNNVSYNELIEYILKSALQRRRGRVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEW1</accession>
    <name>A0A370PEW1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_267785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620957" evidence="2">
        <location>
            <begin position="25"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="953" mass="96887" checksum="DB38139FDD27CE0E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEW9</accession>
    <name>A0A370PEW9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_267793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="11933" checksum="36E5E71DC67E5588" modified="2018-11-07" version="1">MPKTTSSTSTTRSITSLSTIKEADYYSDAGRRQSGTTSTSSNTNQESTQKVKHRNLENIHRYRDGPRWEDPYCLVERETNGKRVARMRDEFRKVEEVLGSGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFI1</accession>
    <name>A0A370PFI1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_277047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFI1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="38774" checksum="7CF5E5B7EF72FAEB" modified="2018-11-07" version="1">MPALPTTQSALVVQGPNSLRCVTDTPVPSLAGDQILVQTKAVALNPSDWKMLEAAAATPGAISGSDFAGVIIACGEEVQNMSIGERVCGFVFGASPTNPTNGAFADYIVAHPSLCFRVPPTMTFEEAASVGMGLMTVGLLFRSLGLQTHISTNPDAAKTKTNKPFVLVYGGSTATGTLAIQMLRHHGYQPITTCSPRHFPLVKQRGATAAFDYASRSCKEDIRAYTKGTLAFAMDCIADSHATTVCYGAIGGDGGRYCALDRFPPRLEGRRQDIQPEWIHSATIFGEDVQLAGSYHRTARPEDREFAIEWAHHCTHILARGELQTHPLQVQKGGLPRIIGDLPLLRSKQISGRKLVYPVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFL9</accession>
    <name>A0A370PFL9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_277072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFL9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="44460" checksum="D82A64B84F93B24C" modified="2018-11-07" version="1">MGLWSTNSADPCSIRRPRTISIFSRLVLCSTLLLGVSFILKTRPHLLPSFPHLTPSRSSYTQPTTMSYQQERYIAELAVQRATLLTQKVFNEKAKGTVSKDDKSPVTIGDFGAQALIIQAIRKNFPNDEIVAEEEASSLREDKALSAEIWRLVQDIKLVDTESDNLLGGPLPSEEAMLDIIDQGKSAGGAKGRIWALDPIDGTKGFLRGGQYAVCLGLIEDGDVKVGAIGCPNLPVNDAETMSAGIGAEQTSGTGKGVLFSAIQGVGSISRPLTNGALAESKSISMRPVPDIAQAVFCEGVEAGHSAQDDNAAVAKLLGITSPSVRLDSQAKYCSIARGAGDIYLRLPVKKDYQEKIWDHAAGDLIVREAGGQVTDIYGQRLDFSKGRTLAANKGVVAAPKALQDQVIGAVKTVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGS8</accession>
    <name>A0A370PGS8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_252752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="59"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="621" mass="67466" checksum="71F57A987C6A3538" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH98</accession>
    <name>A0A370PH98_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_336704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH98"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="37402" checksum="332FAFBC0B4BED93" modified="2018-11-07" version="1">MTTVTAPAPWITSSQQCTLETCPLSYAHITYLPNLGGNAFYIALFALFIPVQLYLGIRHRTWGYLFGAICGLILEVLGYIARIYMRHNPFIDRWFIMYLVCLTIAPAFLSGAIYVSLARIVGAYSSQLSRIKQRNYSLIFISFDIISLLLQAAGGAITTSNSASEVQDGINIMIAGLSSQVASLTLYIVICLDYAFRVYRLSARNPSPPSNMFRMANHTKQESESQDLVSGSRDLVTLNPDFASLRASKRWKAFLFCQGLAVVCIYIRSCFRVAELCGGFSSHLANDQTTFMVLEGAMISIAVIAMSSWGHPGVGFHGRWDALNYPMFQRKKKGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI98</accession>
    <name>A0A370PI98_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_216379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI98"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="366"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="54872" checksum="56F39006522C826A" modified="2018-11-07" version="1">MSGFPAQQQAQARNAALASARLPNGKLGSGANWNFNLPVSGTPGIQGNQQRSIGTMGTFAQSLSGSQPATPLDLSDFPSLSGAPPQSQTQNPSHLVWANASQRAMQQTPVQRPQHATSQAPSRAPQTQTHHPQQQSQPSHDDVFPSGAQFANRLDDFRNGGQGISGQLGAGGQPQTGNIEEFPPLGRNITTDLGQDRRGSLIQSTGLGNYNGGLSFTGVSQAQSAQARNMVAASVNGQERIMSPATAGSGGIETSRSPVNQGSSRVPGQEKEELNSSVISNQSAYTEQQHIMRPPGFPATGKEASGAAQSSDQLPLAEMSELDKFGLAGLLRMIHSDNADVSSLAVGQDLMTLGLDLNQPEPLHTSFASPFVASMPGVPLEQDFALPACYNVANVQPLQTRIPSFSDETLFYIFYSQPRDLLQEVVAEELMGRKWRYHKIERCWLTRDETYPGPVDVDRGVSERGVYLLWDPASWKKVRREFILRYEDLDNRMDPNRGLARVGFPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIA4</accession>
    <name>A0A370PIA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_22028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="73" mass="8015" checksum="1F3DB8656712A576" modified="2018-11-07" version="1">MVRGTAWLLLPCSTDWHCPSLPCVVSSCAISVTLIQPPSILTFSIESPTQQPSHNILPYQHTTLTLEWVLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIC2</accession>
    <name>A0A370PIC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_327291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIC2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="153"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="56302" checksum="5E1C250D3110FD68" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJB9</accession>
    <name>A0A370PJB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_335919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="433" mass="48002" checksum="F50472C7E5037AD3" modified="2018-11-07" version="1">MTIDSVLPPKLRVAIIGAGPAGLGAAIEFAKLPFVELRVYEQARELREVGAGISIQQNTWRMLDMFGVYDNIDPKDLFRPADGHSVQHRNGRTGELLLSKAQEGTPPRYLHARTLRSVLQQALLKGVDKSKLRLSSRLAEVVQLASGAFFLRFEDGHTDEVDLLVGADGVRSVVRQFAHPDHRLKYIGTTAYRALADARDILSIPGIPDSVTFWHGPADRLYTCNLKNNVYEIAARVPQTAETAPVSWGQDASVEEFSWRYKDFSPALQSVLDKIKVVKKFALFSGPRLSSVISHGSIALIGDASHPLSGAFGAGAAFALEDVYVLTRAVKWAHERGLPIQDGLELFDRVRTSHYAAMYDILDGYGKSDVSVKATDDFDEAVSMIVANKWDDDHGWLYSYNVEEAWRETYEAEDARRAAVEQSARGEELNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJF9</accession>
    <name>A0A370PJF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_300525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="580" mass="62251" checksum="7CCAD71D58FAAAE4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJR9</accession>
    <name>A0A370PJR9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_15954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="60809" checksum="E7CF5D92CAFFC34B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJT7</accession>
    <name>A0A370PJT7_ASPPH</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_300715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000699">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="521" mass="58370" checksum="3D290ADC14AC5470" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK38</accession>
    <name>A0A370PK38_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_251748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000005">
        <property type="entry name" value="Sulfite efflux pump SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45186" checksum="B00D8776191F786B" modified="2018-11-07" version="1">MSGQDPNSQSEVTKHDTGWRRVVRHFTPSWFSVTMGTGIVSILLNTLPYNGQWLYWISVVCFAFNVLLFAIGCTITFLRYTLYPEIFFAMIKHPVQSMFIGTFPMGFATIINMFCFVCVPAWGDWTRNFAWGLWIFDAIFSVITALSLPFLLMAHGSEMQLSSMTAVWLLPIVSCIVAASSGAIVADVLPDPQHALWTVLVSYVLWGIGLPLALMVMVIYLQRLTLHKLPPKAVIVSVFLPLGPLGQGGFGIMKLGQAAQEIFPKTQTLEAASGPIFYTMGFMIALILWSFGLVWLFFALASIARSKSFPFNIGWWGFTFPLGVYATSTCQMGKELPSEFFRVLGTLFVMFPDVDVRQILSLCVVVLWIVVSIGTLRGVVSGRLFFAPCLGDLKARENENKDGTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK99</accession>
    <name>A0A370PK99_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_215753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK99"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="623" mass="68119" checksum="21B9B11C98BA1B19" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKK0</accession>
    <name>A0A370PKK0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_275867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="343" mass="37768" checksum="BAD1980D0599E723" modified="2018-11-07" version="1">MTSQRIHLIGLGSIGTLIAHSLRSLPAPPPITILLHRESAYQNFVSGGSKLRLQIGEDGPTQETTGYDAELLQGESSIHHLIVAVKASATIPALRSIQHRLGRHSVICLFQNGLGQIEELNERLFTDPLTRPTYMFGIMRHGVYIKAPFEAVLAGLTGSCALGIVNNDQQASPLSASSTVSAQSRFLINRLVEAPIVRSSELPWMELHQAQLLKLATNCVVNPLTALLDVRNGSLLANSELQEMRRQLLQEISLVFRRLPEFQGLPDVEEQFSVARLEEQLIANIEKTASNSSSMREDVRAGRATEITYINGWIVRRGQQLGLNCPTNRCLTQLILAKSSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKY2</accession>
    <name>A0A370PKY2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_233708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="602" mass="67338" checksum="FC2FE6F68DDC9850" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL32</accession>
    <name>A0A370PL32_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GDPD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_163328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL32"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="812"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131285" checksum="09D9B573ADFC4012" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLB4</accession>
    <name>A0A370PLB4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_326714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000003">
        <property type="entry name" value="D-galactonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000013">
        <property type="entry name" value="Mandelate racemase/muconate lactonizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="42563" checksum="EF2C562DD3C23733" modified="2018-11-07" version="1">MVKIKSIEYFRVPPRWLFVKIVDEDGQCGWGESTLEGHTEAVEGTLNALCKRFQGYEADDIEHIWQMAWRLGFYRGGPVFMSAISGIDIALWDLKGRRLGVPIYQLLGGKVRNKLSVYAWIGGDRPSDVEAAGKARLAQGFKAIKMNATEDINWLDSPRALDSSVERLKTVKALGLDAALDFHGRLHKPMAKQLAKALEPHRPLFLEEPLLSEHPEAIKQLSDQVSCPIALGERLYSRWDVKRFLEDASVDILQPDIAHCGGISELRRIASMAETYDVAIAPHCPLGSVALAACMQVDLATPNFVIQEMSLGMHYNTEAGEYDITSYVKDPSVFAVKDGYVDALTAPGLGIEVNEELVRQLAVNSEPWPPKEFFGPDGGIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY3</accession>
    <name>A0A370PLY3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Adenylosuccinate synthetase</fullName>
            <shortName evidence="10">AMPSase</shortName>
            <shortName evidence="10">AdSS</shortName>
            <ecNumber evidence="10 12">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_249792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="10 12"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY3"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="295"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="327"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="424" mass="46195" checksum="F37DB7808F02785D" modified="2018-11-07" version="1">MGVTIVLGSQWGDEGKGKITDMLAQQATLCCRAAGGHNAGHTIVHGDKTYDFHILPSGLVSPSCVNLIGAGTVVHVPSFFKELASLEDKGLEGAGKRIFISDRAHVCFDLHSVVDGLEEAKLGGRKVGTTGKGIGPCYSDKAARRGVRVGEILDEALFERKLRSLDAGYRARFGELEYNVEEELARFKEYRKRLGPYIVDQLAFLQKYKDAPNTLVEGANALMLDLDHGTYPFVTSSSTGLGGAVQALSLNPTSISSIIGVVKAYTTRVGSGPFPSEQLNEAGDKLQGVGKEFGVTTGRRRRCGWFDMVLCRYSQAINHYTALNLTKLDVLDDFDEIKVGVAYILPDGTRTENTMPADPEVLEKVQVEYVTLPGWKSNTMGVKKYEDLPANARAYIEYIERGLGGVPVKWIGTGPARDHMICRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLZ7</accession>
    <name>A0A370PLZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_292401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="818" mass="90393" checksum="6901C8D190F1956E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM10</accession>
    <name>A0A370PM10_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_265131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="391" mass="44289" checksum="E1A6D872AA7AA35E" modified="2018-11-07" version="1">MASLDSAFATSFAKETWALYSVGVLGAILRFVARIRRLGYQNLQADDYLMLFAVVWYTLLCVALNEVASGGGSNLMDENDIKNLTPSIKADRVRGSKWVFVSEHSFLLAIYAMKACMLVIYARITEGLRQRKWVNYLAVYVALGFVANELSLFLICRPLSNYWAVPTPYEQCSTYQYYEIVQGCLSISADVFMLIIGLPLMVQVRVPLKQKLILLILFGMGIFVIVAALLNKLYCLVPSLISYVYMNWYFREATVAILVTNLPLVWSLLRDVFPALKSWTGGSRRATTERYRSGPWTSKGSAFRHYGPHSQLQSGEYSMHNYNQSTVVAPQKTISEVSLEPSDDREPSEDGSERALRIRQDVTVTVERETRPPEYWESKKAQTSQGRLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMG5</accession>
    <name>A0A370PMG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_232988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="585" mass="67328" checksum="9592432B1996BEDF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMX3</accession>
    <name>A0A370PMX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMX3"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="220" mass="24717" checksum="5B193518E9618DC2" modified="2018-11-07" version="1">MSPSTKPTFTTTLIPPPSTTQLTVPPPTTTLTTPTDPLTTALVIRRDVFIHEQNCTPESEIDSDDPRSWQWVVYAHQDTNPTPTPVAVIRLVPPPHAPHEILTHPETASSLPEWDLKSEPYVKLTRVAVVKEWRGYGLGRVLVDEALKWAAQNRGEIERAFKCVAGTEGEWKGLVLVHAQVQVEGMYQRLGFETDEELGRWDEEGIEHVGMWRRISVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW1</accession>
    <name>A0A370PQW1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative DNA damage response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_274847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="169" mass="18559" checksum="B9FE85B0AA4A45B6" modified="2018-11-07" version="1">MSTPDEAVPPPAEVMTIATPINLILLSLFVILVYLQLRPKAPVSLPKGPPPVVFHTFTPTTLLPFNGENDAPVYLAVRGRVFDVTPGKNFYGPGGPYENFAGRDASRGLACQSFDEEMLTKDLKGPLDDLKDLDNEQLENLQSWEERFSEKYLVVGKLVAEGDPEAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQY4</accession>
    <name>A0A370PQY4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_211724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="42"/>
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            <end position="673"/>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="702" mass="77362" checksum="52F4CB5E1B19CE7F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR92</accession>
    <name>A0A370PR92_ASPPH</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">M752DRAFT_324743</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="106" mass="11817" checksum="9AA0CB1F2350C374" modified="2018-11-07" version="1">MTIPLSTISTFRTTFNPFLRSARPCRLILSLLRNPTTTPASSPGHIDIKVTQLPRSSTQEPELTIGFKNGKELKIEVGKRQMKIGDVVEEIARVGRAIEREEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRB7</accession>
    <name>A0A370PRB7_ASPPH</name>
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        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_126913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular response to stress"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
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        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="624" mass="66545" checksum="0E2971F18C4AE859" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSE6</accession>
    <name>A0A370PSE6_ASPPH</name>
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        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_274407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="54"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="278" mass="32195" checksum="B79B2A71E5C5C3AF" modified="2018-11-07" version="1">MARSKQGVFSWEDVLAHRYQNNKPSGLPRSRRYSAVQGQRTSSKPDTRTEWTIQSQSALLAKLSPELRLMIWEMVLGGMRIHIIQRPNRRMGHVVCPQTSACDICRGGLPGIKESAGLLALSMTCKQIYCESIYMLYSLNTFEFSNTWSLTYLRPTIPADFWDAIREVELRWAFPGHWLPCKDPVKSVYFSAGRQQWVETCLALTDMQGLQTFTLQLSGSWFCEPVEKIPVFLEPLRALHLRQRWKLQLPRQPYYVKEIRNIDGDLRKRGIECVVRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSW1</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_273626</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSW1"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="522" mass="57994" checksum="F28E97256D63B752" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT10</accession>
    <name>A0A370PT10_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="866" mass="97815" checksum="4401D311F3E97602" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU82</accession>
    <name>A0A370PU82_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_333468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000183">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000158">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="638" mass="72025" checksum="8B8760843A990870" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUB9</accession>
    <name>A0A370PUB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_123249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="93" mass="10784" checksum="AFDA3791D9031425" modified="2018-11-07" version="1">MRFRFMGMLRMLSTCLMKGMDEREDFIVCFCLIQSRLSGPFCCCCCCCCCFSTCDDFVILLCLFVQNSDRAEVRISLFRVIYSFLILSLIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUH1</accession>
    <name>A0A370PUH1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_317648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUH1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="21965" checksum="F70ECA8E224FA751" modified="2018-11-07" version="1">MTVALPANVDQPQNDTFTSLLSQLRDRSLKPSKVRSLVRDMTASITKSLHIDAPKDETIAIIVVLRSGLAMFDGFVDNIPEDVSTTVYHMGIFRDQASLQPVEYYNKLPVKPAHIKQAYILDPLIATGGTAAAVISILKDWGIEKVTFLSVLSTPVGLEHAAAVWPEGSRFVVGAVDPEVDAKGYVQPGVGDIGDRLYGTAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUM3</accession>
    <name>A0A370PUM3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058689" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27239" checksum="750B06C2D6542F4D" modified="2018-11-07" version="1">MRILLLLFFTLFSITSHSLPHYGVSLPPPPTDPAKPPTSPYYPWKSRLASGADHVDKTTLYSIARAAHNQGQTHFADYLKHYLGNTGRDAHVSVDEMLSAMPQFRTEVHELAKFKAKLAYESLMMTRPDEAPVVPFTSFWHEYIATPDQSWDWFLSVGRFVYSVTGVVKMDNETGGVTVHYAVHVFTYCDWDGGRDVRIGQFRFDEGRLAGLQVTGLAREFKIRGSSQSRLIEGYTPVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV20</accession>
    <name>A0A370PV20_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_228692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV20"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="606" mass="67124" checksum="F91EE09BB2D64F7F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW00</accession>
    <name>A0A370PW00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_101605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="121" mass="13582" checksum="22B8242BD7D2D1B1" modified="2018-11-07" version="1">MLDAGNVCEFGYGRESEEKNSFLSCSFFSIVVVAAANIPLHQTTALLIFLLLLSSSSIYPGMCIFQFKFETDRRLHAHTDRRRRGKNREGSKSRRINCNKLTSNPAALHQERSGQGSLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW82</accession>
    <name>A0A370PW82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_209071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="58226" checksum="1F557A0113DDF5E9" modified="2018-11-07" version="1">MPDFQVVEDVWHEICEYLETRDLFNICLTSRTINHVGTRYLYRKIKWNWKGKKSRYRIMSLWTALVQDKDKRSRLCGFVREVHLLGSTPPKDTRIVECPEIQESNPSSLSIIRSDKVPFYQEIDYLRDVVSSVVESPKGRLAWSESIAARNVYALVALLLPLLHNLRSLKLDYTFAVNGGYPGQMIESLTSGKEIHSAELQNNFEHLEVFDYGTNALHNNLPHSCDNTYIRMRYSSQLIPIFQLQQVKHLKVWLRSRHGLLLARIPDVQMNHRALETLVLDHISVMDCALFKIFKRTNKLRSLHLGMNAEEKDFWYVGIPSADDSKYIWNGLRALCGCLEHLSISFSITPGSREYHIDTIMWGPLFRHMTAGFFQDFTRLKTLELPIQMLNGFRDIMEVGIQQDLPVTLEKLGLRWDFRDVESYDVPTATVRILWVLTEFLRLPDRHQRVPLLQEVIIRLFIGEDGLSRTVVDCDDLIEQFNMYVGVCADHMRPGLWTNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWJ7</accession>
    <name>A0A370PWJ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="47015" checksum="B4DEB2CA84E332FE" modified="2018-11-07" version="1">MPTVILGGGIIGSSIAYYLSQSQPQEEIHVIESASELFSSASGYAAGFLAKDWFAPSLAPLGELSFNLHESLAAEHGGRQKWGYMKGVALSLGSVSNKGGARGDDWLRAGTSRAETAAGTSQYGEPQVPEWLTQQQGAKVEQISDKDTTGQVDPLRLCRFLMDSCTSRGVKLHYPTKASSLVRNEAGTITGVKIVNLNTKSESNIPCTNLVVCAGPWTPQVFRDLFPFSKVALPIYPLAGYSLVLHSPRHTLEHEQKKYHGETHALFTTWPPSCGFSPELFSREGREIYIAGLNTKTIPLPERANDSHKSVDQKEMDRLKAASVRLLGKLAEGKTESSDETPNVNDLKIVREGLCFRPASDRGTPFVGRIDDSLLGEDIKTATGSRKGGVFVASGHGPWGISLALGTGKVIADLVEGVQPAVDISGLGVSRRGLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX10</accession>
    <name>A0A370PX10_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_227618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="49441" checksum="C153EFF87B887676" modified="2018-11-07" version="1">MRLDGVAPPPDAVEPKSQREKDEDVEDLKAIDNAPEVDAFGDEANAEVKYKTLKWWQCGMFMIAESVSLGVLSLPATMTALGLVPSLILIIGLGILALYTGYVIGQFRERHPYIHNLADAGEILMGSFGRELFGLGQILFSIFIMGSHIVTFTVMMNTITDHGTCSIVFSIVAFVICLVLSLPRTIKNLTYISTASFLSIFSAVMITMIGVGVQYKGGQSISITTETNLYTAFSGVTQIMFAYCAHVAFFGLIAEMEEPKDFPKALCLLQGFEISLYVTAAIVIYYYVGNGVDSPALGSAGPVLKKVAYGMAIPTIIGAGVVNGHVGLKYIYVRIFRKSGRMHKNDWVSVGSWIGIGVTCWVIAWIIGEGIPSFSNLVSLISSLFASWFSFGLPGAYWLHMNYGQWWSSPRKCALTIINMLIFAIGGAMCGLGLYASGKAIHDDSSRSSFSCANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXI5</accession>
    <name>A0A370PXI5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="43674" checksum="88F29429F1B965A1" modified="2018-11-07" version="1">MSGPYVPPGQSPPFQVVDDLHHGAWIIITGALGLVVSLVSFFIRLYVRIALHPPFAYDDYLLLGATIVAIVQAALLFDAVSHGFGTSIHLLEQNQVDKIQTLITVSDILYLITVYISKCCVCGIYLRLTPQKCHNRASLATLALCTAWVIPAVFIIAVNCELNRPWKGSGGQCVNLSKRWQFIVALDIATELIIFGLAVFLLWGLFMPLKRKLTIGFAFMFRLPLIIFSVFHIYTILLLVHSPDPTLAVVTPVIWAQVELNYALVACSIFCLRPFMAAVSTNYGTAGDSNLESTSGVSRSWKVDSSKAESGRQTNLNTERRSWRISGRLDGVGYSGRQAGPVAEPTSIELVEMDGQRSVESDGGSVRMMIRKDVEYTVEYDRRRDLSMSGAYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXM4</accession>
    <name>A0A370PXM4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_244997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM_ETP1"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
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        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_UBP"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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            <begin position="379"/>
            <end position="418"/>
        </location>
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            <begin position="415"/>
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            <end position="363"/>
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        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK46936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="708" mass="78728" checksum="BD701AAE5A6FB200" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXX3</accession>
    <name>A0A370PXX3_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_68585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <end position="38"/>
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        </location>
    </feature>
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            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
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            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47028.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="65372" checksum="AD282B4C0E76A1FC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYA3</accession>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_272920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="19"/>
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    </feature>
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            <end position="40"/>
        </location>
    </feature>
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            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="21803" checksum="49298BED6DB10431" modified="2018-11-07" version="1">MGASSSKPARSAAQAVSRRQYPKQPVSPPTSSPAQPPPASKPTRQQPQPPRQPSRPPPAGPTYHSKEPPSLERSSAIDLDGRDPDFAAQLRTIGPVTPNPTFSPSSTFARQQPAPTVFPPASNPALLVFSARQRLTKAAEQELEAMGRSGFQGREYLDALTIRQVLAMRDRQGLSAEEIERLLRLKSGVVGRLGERGVVGDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYB4</accession>
    <name>A0A370PYB4_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_228249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56491" checksum="92BC7BBF07BBACD1" modified="2018-11-07" version="1">MERPRHIEDLADELISDILSYLLGSEYLSPEPSPTSPQGSSRDSDNGTTHAFGEKSELDRFRLVCRRFKRIGTPRKFTSFVLRFSSHEFRRLEDLLNMQLACHVRYFTYMVRPFYQGSGWSHILDGVDVDNLPVSSIHRRRLDDQKYILDSNLDLRLLRRAIAAFSSLQQVKLLRLQDEADEQLLDHIRERSLGRTTRLDWEPACTRAITSLSISLLESNCNSVRFVGPQISPEATVRLLQAPSTSLSALGARLASLDVTFHSAAKLSTYMETLSNVFHDFFLAAKNLTTIHLGFPTNAPLDLALEQIFHHVQWKRLRTLSIQGWRLGSEEIIAFIRRHRRQLRNVRLASVYLRPGGRWREVLTVLHDEMDLLERIDLRGIDYTSNFDANINTNAHHNADAAGPGTGSSQTPTLAIVVQPTPDMAPHKAFLNMDYYSNSGPPGKTRRSFSETTLEQLRGHTSDVLGDNGESVSHDQRLLWEAWVLSSQRSNVHRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYT1</accession>
    <name>A0A370PYT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_323716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYT1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="366" mass="40090" checksum="CAD295E65AFF92E1" modified="2018-11-07" version="1">MKYPWLRPLKAKALQQIAQKTGIQSSGTKAVLVERLEGELTPLFPHIQNDRGKLNEHKNEKRRNNDDNDGIRVLSIDMGIRNLAFAVLHSPYPSSSSFSSSVSISSTGSSEAYTPRDKVKEGNSITLTAWKRLSIPDLCYAQHEGTPSLITTTTTKPKSQVTEEAKEDFSPSLYARHAYTLITTLLSTYNPTHILIERQRFRTGGGSAVQEWTIRVGVLEGMLYAVLETINSSLLSSSSFSSSPSSGGKVQVYPVEPGRVSRFWGEESGDIGDGGGDMVVKKQKKRKNVRDVKKMKIALVREWLVSAANDDGDGRVVLGGSAGEGDEVRELASAFLEKCEGKRRTKKGEDGVDIAATFTSTSRDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYV6</accession>
    <name>A0A370PYV6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_306717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="791" mass="85738" checksum="166A5790EABD6906" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYW2</accession>
    <name>A0A370PYW2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_207562</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="21036" checksum="0798128B836BDEF2" modified="2018-11-07" version="1">MSLCQNRLTEERYVADNVAYASYGVSFLKLTPNATIYRKQWRRDHPFGFYAKPHRTPQGTLDLKRWECGIPGKAQTLWEGGLFKLDVTFPDEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEEEAWKPAITIKQILLGIQDLLDDPNPESPAQAEAYNLFKKDRPAYEKRVRQVVRENPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYY2</accession>
    <name>A0A370PYY2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_331248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="31897" checksum="710DB5DBC917E647" modified="2018-11-07" version="1">MSLTCTHVTPECPVTATTYGYYPNLGGNIFFAVYFGLLGTLQLGLGVYYRSWTMLIAMVIGGYMELAGYIGRILMNHNPWDQGGFKLQIVCLVLAPTFIAAGIYLTLKHVILSLGPEHSRLKPRLFTWIFISCDVGSLILQAAGGGVAAAAGSENQNLLKVGDDIMVAGIAFQVGTMSVCGLLALDFFIRVVRKGPGLGGEKYIDENGNLTGPKHLRVIVWAGIVAYFATLIRCIYRIPEMAGGWGNPLMQKEDEFLVLDGMMMAIAVSCLTYLYPGFFLQSIRKGMKKTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ09</accession>
    <name>A0A370PZ09_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_322501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="583" mass="64144" checksum="545C601EC60F77FB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZJ7</accession>
    <name>A0A370PZJ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_260972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="16736" checksum="DEB37CDED9EE3F7B" modified="2018-11-07" version="1">MLIGDNFEPVLATTGYLLFRVQVRISEHQARTTTSRFNKELFTIWEVTYRILTSKSICCPRTHGCGSKTMHFLTVMASIPGKYTAKKQFNRAVNVATDDDLAITVSLIMAQVAKVVTGPCFHNATVEALCRLKLSRLCLITIQIRVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZV5</accession>
    <name>A0A370PZV5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor-a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_4153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000308">
        <property type="entry name" value="Possible replication factor-a protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="288" mass="30210" checksum="54FF30AD9E826E50" modified="2018-11-07" version="1">MDGGYNNYSSTYSGGGGGGGGFMPGEMNNSPSGGKSDYTNSTLRPITIKQALDAVQPYPEAPYQIDSAEISSICFIGQVRNISSQSTNVTYKIDDGTGEIEAKQWIDSMTADSMDTDDINNTKAATGRRDGKVELNGYAKVFGKLKSFGNKRFVGAHCVRPVKSLDEVHCHLLEASAVHLFFTRGPPGGGASGAGGVGDVGAKGDAAMGGTGDDYGAGKNLPAMSPVAKRVYQLLRTEPQSNEGLHAQLIAAKLSLPMPDVARAGDELLTAGVIFSTVDEQTWAILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q068</accession>
    <name>A0A370Q068_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_288310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q068"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38210" checksum="9C47CBDE3FC89287" modified="2018-11-07" version="1">MTLTDYASYPDSPDLAALNLSRLVARLEHNLLSSAADLKPLRRSEYQRMRVGANIEYARTNLQTLERTLPQIKPTDRRNDLQTDLARQRQILKQLQIVLDEISSSQAEPQSDEEEEDDSLDGEDLLDTPEEGSTTDEQFEHEEKERDTITDDHEPATTAPTSTLPAPTTATTTTELPSQTPEATPAPTQEQPSTLRNRSHAPTTTPSTATASATGSSIQKNPPSPQQSSDASSDARLQATEETLSSHRAEQENLTSSMLALATQLKTSAQTFHSSLEAEKSVLARAVDGIDRTAGNMKVAEQRMGMLRRMTEGKGWWGRMMLYAWIFGMWVVAILIVFLGPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0L6</accession>
    <name>A0A370Q0L6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0L6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016762562" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9282" checksum="F5DC686F140D68EC" modified="2018-11-07" version="1">MGELPALLACLPLPPMLALLCIFSGLGKSCHGGPDRPPTHSGNQAAVQPIFFFRKIIYRFGTDVGRNSEVEGGLDTERLLGIRRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q125</accession>
    <name>A0A370Q125_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_331850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q125"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="319" mass="35454" checksum="8CD61DD14163B3D6" modified="2018-11-07" version="1">MTLSRTLVWNYNAWDKGDDDMPKFPGLVFDYRNDPVQQIVIAPPADEPPFHKLNRCPRPPIMDSPSLCACATASLPYHFTMAPFRNFLSRKSTAPNGGEVSAAPNDNSASQVSLDTHGSSPLSFRKSSENEPPEYKLSVVDANGIYHPPSPPEKQGFWRKYPGSPRSSHHRDLVNENEPFSISRESFDSYRRSFDISARSPVCYTDAMPSRTSLDSRVSHITSTPSTLYSNLSKQPEAMEEEQYEEVALDDEEVKPKRKSIFSRFGDFTNDSSQNSSTTKSSTLGFHIPGRKRGPSNVGSELGTFKAPPANAESEVHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q127</accession>
    <name>A0A370Q127_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_272347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q127"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="106"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="548" mass="60706" checksum="3392E5BDD09289E3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q131</accession>
    <name>A0A370Q131_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_316703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="77"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1334" mass="150614" checksum="81EA70AA311C6712" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1R9</accession>
    <name>A0A370Q1R9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_331787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1R9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="109" mass="12443" checksum="1A65396A26939625" modified="2018-11-07" version="1">MMATGADDRSNMSIRKQNEHLMSTSATERAWQIIWAHPTNLIWTVQQEMVRTQNDDDESLGQLIMPIRAQNTESPTYPLVSFHRRSEQKQLAGSLIQPVGVSEIEEGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P488</accession>
    <name>A0A370P488_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_243129</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A370P488"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000006">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000676">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016945046" description="Vacuolar protein sorting/targeting protein 10" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1351"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1400"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="50"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="705"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK36610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1483" mass="165460" checksum="2610D8809C4841CE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4B1</accession>
    <name>A0A370P4B1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_280232</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4B1"/>
    <dbReference type="SMR" id="A0A370P4B1"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01582">
        <property type="entry name" value="Homoaconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="68"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="584"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK36706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="769" mass="83363" checksum="2131A00345B50456" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4K9</accession>
    <name>A0A370P4K9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_322198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4K9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61038" checksum="E4EA7FFA61F2DE11" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4N0</accession>
    <name>A0A370P4N0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_310808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4N0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
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    </dbReference>
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            <begin position="22"/>
            <end position="609"/>
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            <begin position="21"/>
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            <position position="144"/>
        </location>
        <ligand>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK36829.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="609" mass="68001" checksum="D3B2559214B36CBB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P535</accession>
    <name>A0A370P535_ASPPH</name>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
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                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="RDK36978.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="38409" checksum="DD568F432ECDBB73" modified="2018-11-07" version="1">MSDDSGVLFVGSRPRKRTHREISEVSEVSSGRPSGEPSSSSLSATPGPSLPPLRRYPGDGLDLRRPATSQPSEDVIDLTDEPDTPYQNSSLQESRTTTEASRPRPPRFPRDILTEVVDLEEEVDDNDQQQPPSSPEVEFIGATVRRPQLPPPPQPPPPPPPRNNEGFYMPSLWQQMLQFRSPRPPGRFGDHGRPDLSFRGFRRHPPMSDVESLWIGDGPAGAIDLTINLDVDGPLGLDYQLTGLTRQRTPANAYKPPSPPPEGFTRNVAEDDVVVCPNCDMELGTGDETKQQIWVVKQCGHVYCGDCASNRSLSKAKKNASKAKPFSKCQVFGCGKPVSSPKSMFQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5G1</accession>
    <name>A0A370P5G1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_106634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5G1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="622" mass="68819" checksum="EED276CFCA6CD541" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5N8</accession>
    <name>A0A370P5N8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein import protein mas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_259343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="45912" checksum="EAE4F43D10535643" modified="2018-11-07" version="1">MSKADVDLYEVLGIDKSAGKDDIRKAYRKAALANHPDKVPEAERQDAEVRFKAVQEAYDILYDEEKREIYDTHGMGAFNGSGEPGMGAGPDLDDILAQMFGGMGGMGGMGGMPGGPHARKPRKSPDEEQKYEVRLEDLYKGKTVKFASTKNVICSLCQGKGGKERATARKCSTCDGEGYKQILRPMGQFLSPAMVPCPTCNGAGDYFVDKDKCKKCKGKKTTEAKKLLEIYIPRGAREGDKIILEGEADQVPGQEPGDIVFHIVEEEHETFRRAAADLTATIDVTLAEALTGFSRVVVKHLDGRGIEIQHPKTPGEVLYPGQVLKVPGEGMPIKRSDARGDLYLVVNIKFPDGKWKPSPAVLEQLKELLPKPEPPIQADTVDEVEFDPKGNLDDFGAHDPEGGSAWEDDDEGETTAQCATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6A4</accession>
    <name>A0A370P6A4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_93469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="479"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="94117" checksum="CEBA56046B692F2D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6C6</accession>
    <name>A0A370P6C6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_279676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6C6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="16945" checksum="DB9C0BCCA70F8F1A" modified="2018-11-07" version="1">MADIDVQVAQWKLVEVGRVVLIRSGPYTGKLAAIVEIVDHKRVLVDGPSTEEQKIVPRHVLPLSHATLTHFVIPRLPRAAGTGPVKKLWQKEEIDGKWAKSNFAQKTERAERRKNLSDFERFKVLRLRKQARYEVQKAHAKLRAAAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Y0</accession>
    <name>A0A370P6Y0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_309080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Y0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50827" checksum="0FD95A9A6AB288C9" modified="2018-11-07" version="1">MALRLLRRSYRGALPLFLHPVFVPGEAYAFRFDSYLLKMINPHLHLDTPQSHIIFIRPGTEPHTLPLSGSLGISNKVRLDLTHSAPNITISLVRIVNFDDHGSSCTHIKGRRRNPFRHGESATKQLIVPAYEETVLDCVLWSASDKIASRWTTSTEVSLVYYFDIPVPNCLPPTMKTTLGTVCYDLKATINLPFGRTVSISKPLAVLYRLIPPVLPPDNYFRRFTASPLVIQTTIAQQRPSNETIKAMFSVELATRNMLTPGVRVGEIKHIAITAIKWRVDEIAVHRNAARGELQALANTNTASRRSLIEGVLDFRRPKAIFRRSDQDCLRDDRFRVEFDIKIPESAKPADEICESYCTSDDRQSGCSLADAPGIAVSHELKIELITRVDTFSSETNNLLGRESIAKLYGATYPLRIHKLADDVDLMETYYIDKPPAFDVVQQMLPPKYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7J7</accession>
    <name>A0A370P7J7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_81743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7J7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="71" mass="8193" checksum="102CE09EF8DD8B78" modified="2018-11-07" version="1">MHTVSNAGGECAGTIIHRSRKRKRKMKQRNGRSKLRPACACKLERVYTVLTQAVYFVVIRRGVRRKCFADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7X1</accession>
    <name>A0A370P7X1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_222248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7X1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="38076" checksum="F21363A321DB7AB3" modified="2018-11-07" version="1" fragment="single">RQCGIPVHKGRPAVEAATIVPLAISTILFFNRVLAKIMGLGGGWGADDVTIAIAWALAVGIFAVNFKMIELGFGENMWDIDPMDNITLIFKCFQGFVVMYKTQVSLAKISVCLFLLRIFQSTLFRYTTYAVIGLNAAIGITWVLTDSFRCIPVHLAWTQWEGLETGRCVDFIAVTFANAFVNIAVDIIMVLMPVYEVTKLNLSARKKVGVSVMFAMGLVLTAVAIIRVVVFWYNRWNTNLTEQLQPIVHWSVLETQIAVMCACLPTFRAMLVHLFPKVLGNTSDHSSYGKRNTPSGGAAFGSQQPLSKSHINKTVSYSVDYGGKKKPQRSSFVQLVEMDPQAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9S8</accession>
    <name>A0A370P9S8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_329510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9S8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017077059" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="278" mass="30893" checksum="443CB1A089A33156" modified="2018-11-07" version="1">MHFLRPKWFIVLGFFVTTSPAVEVDLVFPRSDASYSPAEWFPFVFAVQNTERAELLNLQVTCNIRKRNATLKDIDNQLYLNHDFSWTNWSGSADPYLAYNYIHNDFNTSNHWLLLCVLSWQSCDVEALTHGPYAYGGVSDHDYRWTMRFNIDNSSLKEVDLVAATANDTCPGSQNAISINVTDRVMNSPSYGNTAHRETCVVTTNTTASPTTSTPDPCRIAIDEDTAESMASVQQQRFCYLPVPPDNCPKEENGATPLAVLGVTGMLTAIGALGFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9W4</accession>
    <name>A0A370P9W4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_305466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9W4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="889" mass="100355" checksum="ED285944200EE15D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9X3</accession>
    <name>A0A370P9X3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_307055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9X3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016705767" evidence="2">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="626" mass="71013" checksum="1CE5760AF6A63DF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAB5</accession>
    <name>A0A370PAB5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_305746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="310" mass="34063" checksum="C421EBFEB5AD0E64" modified="2018-11-07" version="1">MTPARWLLSASVRHTRPALSSALPSIVTMTFSTFTIPRHLDHNGSATLPVSCPAELSREDLLRFPAFRIWLTTLQHSLSRQQHPSHEFSKDPYILRKIDIQSVDRFGGGRLGFLKFKAEVSNENGETLPGSVFLRGGSVGMLLILQPDDVPPSAEDEKRAILTIQPRVPAGSLAFSEIPAGMLDDSGSFAGGAAKEIQEETGLTIPQEELIDMTSLALSSVPEEGETLQKAVYPSAGGSDEFIPLFLCQKRMPRKEIDSLQGRLTGLRQHGEKITLKVVPLRDLWKEGLRDGKTLAAWALYRGLKEEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAI7</accession>
    <name>A0A370PAI7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAI7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="43952" checksum="513443B1889AB157" modified="2018-11-07" version="1">MAYYEPQGWQAPAARQASWEQPAPPSRSGSSSVSQRDEIPAFSSQFDEVDRAIDNLVKSGKLWAAPRRDSMPMMMGRPYPDYDPRMVNSMSQRHHSISEFDSRMHPSPNVQGFYASQRFQGRPNEVEQMMQAKRRMAAQRERELRNYHQEQQYNRSLLAEMSGNKSDRSLSPAAMSEESRRELLARQHRALYGNDSPAFFPPAGLADDGTRSESQAGGTPTSSTGVRGASPRNVDPFGLAQTPVQAGADSLGQTAASAASLQSPSRANSTSSPSSAINPVFGKYDSADQPVTSTSSPGGADSPSSRQAPSKSMAGPIGSVGPIGTRPLPQPHAGQVSNPALNKRSTTPLPSPLGFGFTPGDAASDRSVPSVSTAPTTAAATASVKDTSGGVGLGWGNGSGVWGSKNGLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAT7</accession>
    <name>A0A370PAT7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="154" mass="17145" checksum="C4AAF1C03D5A050C" modified="2018-11-07" version="1">MPAEVHTHTISTPHAAGREQNSKAEARSNSQCTVSVSAVSMRTHERGHLACVTQQAPVGSEVSKNIDGKHPQRKSKDTLLRPLLSDMIPHDRHGEVTNTTKIKNPCQHRARQKRPRHVYAFSTPIFHTAPFLPPDRTNCPHTCRKSTASHILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBC1</accession>
    <name>A0A370PBC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="151" mass="16858" checksum="376B02441EDEE353" modified="2018-11-07" version="1">MGRLHSKGKGISSSALPYSRTPPSWFKASTEQVVEQICKLAKKGATPSQIGVVLRDSHGVAQVKTVTGNKILRILKSNGLAPELPEDLYHLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKSVGVLPPTWRYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBE8</accession>
    <name>A0A370PBE8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBE8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="222" mass="25559" checksum="A4F1E7278CB467EE" modified="2018-11-07" version="1">MEDNLHGIIDIKDRRRIQNRLSQRKRRERLKQKDNDKHSRGLGCPDGRASSTLSSRAPSELDQVIVGGPEMSMDTTTVPELLEDCVLFPDEQFTEPVMSLTADGALLDSTQADLSNYHRPSRRDVSGPERILRPNNSAGEQCFWKETNKSARSAHRHVDPDERPLSILKWKADRIIDQVLSMYQFSVQLEIVEEDPAIVDIMERVRARFQRLRPFHLSVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBI3</accession>
    <name>A0A370PBI3_ASPPH</name>
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        <submittedName>
            <fullName evidence="10">Rho-type GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_50059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="863"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134862" checksum="3B9E2E7C0B17157F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBQ5</accession>
    <name>A0A370PBQ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114872" checksum="59FEAD8E47411636" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC77</accession>
    <name>A0A370PC77_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_52809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="15068" checksum="6C4A642E948E23B7" modified="2018-11-07" version="1">MLLLHRTTWGWMRLYEKSTPPRQSRAGIALLGTTTTTTYRSERLDSLLSWLHSPSLLGLSYSFHTCWTSEVQSSHPRLASSSRDFLLSMDIERQHCREHFYITHIASAVFPSPGGPVYDTESPDQEMPWHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCC4</accession>
    <name>A0A370PCC4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_277789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="447" mass="50133" checksum="F9418E89439EDC5A" modified="2018-11-07" version="1">MGVSKAELHEPVPSHSWVWEALLSRSLVSTHYTALAFLLAVCIPSAPRKSILRYGLLLLQITCALQAFVAPPPPTSDSAVLYTTGVLMANLLARYFDRLYTTVPEESFHRISSTNQSEEDATKLPITQRLPWALELFSVTRGIGWDWRVSRIPELTAPKSRARFVTARLLTIITMYAGLYLLEVTCQELLASYPSPGIADGNPIQILMGDLFLYGLIVLGLALVIYSHFALFVLPLSILCVGLQIGPVAWRDMSAWPPDYGSLWESYSLRRFWGITWHQQLRRHTGAPAAYILSLLPEAMRTSKRRPARLIRRYLFVLITFVVSGLIHTFGSYHVSRGMGMPSSYGGEVKYFISQAVFIMIEDFVCWMLGIDDRSAGEASTVRRWVGYTVTAGWYFWSRVHWSVMPVALASGIQDERGPLFIALEHTRRSAAAVPGNFVAKAWKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCD4</accession>
    <name>A0A370PCD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="87" mass="9874" checksum="697612165E693A3C" modified="2018-11-07" version="1">MHQMLIGRSRPVIGNLGQRLQSADPSQRRRHIVRSDTYRKDSSEPGHIPISSLRVHGAAWAVAGASMYATLHGVYMMLKSFRQIRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCK1</accession>
    <name>A0A370PCK1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_254786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF91">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="568" mass="64630" checksum="08F8D85996AE81F8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE72</accession>
    <name>A0A370PE72_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_218915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="143" mass="15807" checksum="7E7FE26F397CD4C9" modified="2018-11-07" version="1" fragment="single">TSSDMITLYESKNRVDGIVGGNNPTGRQSSRLHARPTLLVVPYRRYPIQSSRTFVWILGITGSRKVHCPRAKFHHKGVRTMLWLLATVPAEATVSSSFVPVTNGFNYQHHQTVLFSGVNAPDQRPLVKRHPSFGSAALSSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEP9</accession>
    <name>A0A370PEP9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_277694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="24881" checksum="1268C5F6F6CAB1DF" modified="2018-11-07" version="1">MVGHGMTGMLGEDGIHVDMNHLKSGEVNLGTSIMAINFKDGVILGADSRTTTGAYIANRVTDKLTQVHDTIWCCRSGSAADTQAVADIVSYHLNMYSITNNEAPSTQVAASLFQELCYENKDMLSAGIIIAGYDPKHGGQVYSIPLGGSLHKQPFSIGGSGSTYIYGYCDAHWRENMTEEEGINFVRGALQEAIKWDGSSGGVIRLVVLTSRGAQRHLYLPDTGYTGPGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEZ5</accession>
    <name>A0A370PEZ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_236810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000014">
        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="462" mass="50049" checksum="88BD38A8112F28B6" modified="2018-11-07" version="1" fragment="single">MLLTNATILTLSPTRTILTNGALRTQSSYITDIDKTPILQAKYPDDEVIDLTGHILIPGLISTHMHTAQTLLRGCADDLELVSWLCERIWVLQGNFTPQDGYAAARLSIAEMLKSGTTCFLESMFADRYGFDGLCRAVEESGIRGCLGKIVMDTGRYAKDDAWAMHPGLIEDRETSLLGTMKMWEKWNGKADDRIRVWFGARTPGGVSPSLYKEMTALSAKHNIPITMHCAEVSADRDFFSSVDHTPMTYCDSVGLLSPSTVLVHMVHLDDGDISLLAKSGTHVAHCPTSNAKLASGTCRVPDLQRAGVNIGLGTDGAPCNNTCDMLQEMKLAGIVHKGVSGNPTVVSAEEVLEMATINGAKALGLQDSIGSLEVGKKADIVAIDARGVEMQPWFNPVSAVVYTATGRDVRFVMVDGRVVVREGELVTMDEGEVVREAERRSREVVERAGLGGKVGARWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFC9</accession>
    <name>A0A370PFC9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dienelactone hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_328051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55145" checksum="3D46742CEA77C252" modified="2018-11-07" version="1">MASISINAPGATGFIYNNANLGTARVCISAETPDFDTETLRAWADEGFDVVYAPYNNGGKEYEARLKSVKEGLGVGDNYAVIAFGDAASYCLDYYLKSTNCSRLAALIAYYPTTIPDTRSRFPFSVRVLTHLAGDTVDVVTIPTVIGLQGKKHRSTKQITPGIGTGERLQIGWPAFTYESAQPGFAEHDLEEFDRLASDLAFSRTLQVLRKAFGKDLDLENRWEEQLEARFFSMNLTGTMEPYVGHLNPTLTCTPTMSGGIGTHALRRFYEQNFLRKLPPSMRLRLISRTVGADRIVDELYATFEHTQEIPWMLPGVPPTNRHVEIVLVSIVSLRGGRLYSEHMYWDQASVLVQVGLLDPKYIPEGAPQGVDRLPVIGREAARRIVEEDPEAEGRDYHNRLIRRAKAKRGKDKPVEESGTELAKSDTEKVESKPAGESKGKTVQREQNGNGADALENHGMEENEKDREKKNGEDANGEEKKPVNPAAATVEDTKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE2</accession>
    <name>A0A370PFE2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_285021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="662" mass="76508" checksum="D00CD97C685D335E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFW4</accession>
    <name>A0A370PFW4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_336916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFW4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="768" mass="86539" checksum="71BAF2AD9EDF0E8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGB9</accession>
    <name>A0A370PGB9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_236300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="510" mass="57360" checksum="4688FFA082B7F36C" modified="2018-11-07" version="1">MVPAFGLTGAESKAGSIRSDGKRELKENDCYDKLAYCWPRWKKWSYLAAIACVQVSMNFNTSVFPNAVKPLSEAFNIGEQEARTGQMIYLITYSIGCELWAPWSEEFGRWPILQLSMFLINIWQIPAALAPNWGTIVVARGLGGISTAGGSVTLGLIADLYEAEDQQFPLAFIVLSSCIGTSIGGVIGGPIERYLDWQWFFWIMLIFGFTVEVILLFVPESRSTIIMDREAKRRRESGEDPNIYGPNELKNPRISLKEAGKIWIRPFYMFLREPIVLCLSLLSGFSDSLIFTFLESFSIVYEKGWGFGILGQAWAVIPINIGYVIAYFSYFPWFWRDQKIRDAKGDDALPAERRLKWLLYLALLEPIGLFGFAWTSLGQEYGVPWIASMIFSTLVGIANYAIYLSSVDYMVAAYGVYSASATGGNAFCRDLLAGIAAMYTTPMYENIGDKWHVEYATTILACLSCLVVLPIYIFYWKGPQIRERSKFAQTLASDRKANQGHRVSKEDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGD4</accession>
    <name>A0A370PGD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_336994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="273" mass="30211" checksum="CE7B8C0939007E0F" modified="2018-11-07" version="1">MSSDSSNLYGYVPSGIVAIVFGAIFLVLTVLHLWRIVRTKHWFGIATLVGGIFEVIGLAARAYSHHDALAKGPYIIQVLLILLAPIIFSAAIYMFLGRLIRATGHAELSFIRINILTKLFVLGDVICFFIQASGAGKLVNADTTSAINSAQNTVLVGLGLQVVFFCIFALCAVVFHVRISRPENKMNVDPALHLNWMLYSLYFSSAMIVIRNIYRLVEYKTGTSGYLQVHEWPAYVFDIAPMACMMMASLFWYSADTKAVRVPGSYPLVSQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH26</accession>
    <name>A0A370PH26_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951412" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23746" checksum="8ECED62910511DCA" modified="2018-11-07" version="1">MFQVPILIITLLGAVATAASHANITFSKNFATERLNFDSPFCDLSEFGYLGGQLPKVYELSPNNSAPVYLPDESFSEFHRIISGHSNASSDFLAQQGTLFESMGKRSTTNSISMLLRNSAGGGDTFAVKANHKVCHTGSHSPWHYAVVYWITEAYITFWKSTACNGHKGSFNPVCDYYDDPSEVCIFNFHPNSFRVYSGCHHSYGWGKGCSSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHP8</accession>
    <name>A0A370PHP8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHP8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="200" mass="22908" checksum="C0062C7269E597F1" modified="2018-11-07" version="1">MKWEQPGSVIFEEGDILKGLPYPDETFDVVYCAQVFGYLPPPDLPFRALSEMRRVLKSGGIIATRDGVDQHFYPRSLNLDRLWVQNFNRAVHWSDGSWSPDADSTAAIMPALFRRAGFNADAGRVRIGVGTTLYSGRETREWLAKRAESQLQQEDPLRQNWLRAGITEEEIHHTLLAVRKWAETEDAWYAALQCEILAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHX4</accession>
    <name>A0A370PHX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_301026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="53"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="442" mass="49745" checksum="DE7A866CA13B50D9" modified="2018-11-07" version="1">MGSIDISAAKPDCNLFSERGQHAVELGASRITWDIISDMWHPQKNPSGYLSVGMAENTLLHDTLLEYINGNTHLSAEHLTYNNGSMGSNALRKAVSHFVNRHFTPSRPVKPGHILMTNGCSSAIEHLSWTFLNPGEAILLSKPYYSTFIADITLRPGSVVVPVEMGGMDPLSPEAVENYERAAREFEAHTGKRVRAVMLCNPHNPLGRCYPRATIDKLMRLCQSRRMHLISDEIYALSVWNNRVDKDISFAPFESLLSRDTTGLIDPAYVHVLWGMSKDFGANGLRVGAVISQSNPELHIAQKCLSLYSFISAMSDQITVSILQNDDFTDKYIQKNREMLSHSHEFLVRLLQKHDIEYLPGCHAGFFVWVNLGKKYRETHPGEVEEGHALTDTLFQRLLDNKVYVAHGTAYGSESPGWFRLVFSHPLPWLEEAMIRIVRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIC7</accession>
    <name>A0A370PIC7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U-box-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_266600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="8">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="284" mass="32010" checksum="E20CCDDF063D6A6B" modified="2018-11-07" version="1">MALELKEKGNQLFKEGDYNGAEEMYSQAILKNPKEPTFFSNRALTRIRLENWAGVEHDARAAIDLYGAKSPTSLKSSWYLAQALLGLQRPQEAYDVAIEGYKASLAAKNIQTENLSRTVLRAKQAIWAAKETARIRELDETLASVEGLIEAEMERGLSELKGRLEKGEIGEIGFREDEREIREDAERKVQRVREAFAIASEGKVVERVVPDYLVDGITFEIMHDPVITPSGTSFDRVGITKYVEQAKVDPITRVPMTVNDLRPNYALKAACEEFLDKNGWAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIT4</accession>
    <name>A0A370PIT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_252538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="547" mass="60337" checksum="701B73822C94E0F9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIT9</accession>
    <name>A0A370PIT9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_24270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="153" mass="17453" checksum="39E88A999F510EAC" modified="2018-11-07" version="1">MSMSGLTAVVGHMVNLFNVQLTKFLHLSEPMDPAKPWGPSTHIPVLFVWWSLHPQVFFSFIVSLTALVQAINGNTVRRSGHLRLYRQPDYGHVQRINPSDVPEDWKCTKASCNSHRVENEPLGTVFVLNSDKEVRWLPFIDFEIFCCEVMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKD0</accession>
    <name>A0A370PKD0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_318877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKD0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="45159" checksum="4930C91C43100CD4" modified="2018-11-07" version="1">MVASTLPQQADIEYMPDHDKYLARSKRRQDTEQLAMHLPEGFPAQLSGDLVWDAKTAGRYDWNYQLSTGDISEIDAALRYFQSLGKPIGELCPDTFPLPKLHPKLRDISRQVHEGYGFKVVRGLPVDEYTREENVIIYTGLSSHVAPIRGRQDSKWQGRPADVMIAHVKDLSQSCNSKDIPGPVVTADKQVFHTDAGDVIALFCLNEGAWGGESYLASTCHVYNVLAATRPDLIKTLSEPWPFDDFAPTGDVYKLRPLLYYQPATERGPERLMIQYSRRNLTGYMDCKRSANIPPLTEAQAEALDAIHFTAEAHAVSLDFRKGDIQFANNLSILHARGAFTDSSEKQRHLLRLWLRDPEYEWEKPSELKERFDRVYDGVTVENSVYPLEATIRSNNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKL8</accession>
    <name>A0A370PKL8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_283784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="423" mass="45627" checksum="097E90A8232C5E0D" modified="2018-11-07" version="1">MHTTEKIPSFLSRRKPSNDSEHVPPPPDGGVQAWTQVVCMHFVFFNTWGITTSFSVFEQLYTKILPQSASSISWIGSVQVSLLFFLSALAGRATDAGFFRVMYPLGVLLQLVGIFMLSLCKTYWQIFLAQAVCMGLGNGLTFSPGLSVMSAYFMKNRAFAVGLAASGAATGGLIYPVLINQLLYNHQIGFAWTIRAAGLLMLITHIFGLVFFRPRLPPRTTGPLIELGAFTEPPFVFFTLCYFFTFWGLYFAWFYLGTFARDRLGIADTQNLLLVLNGVGIVGRIGPSIIGDRWTGRLNILIPITLSCAILMFCWIAVSTVAGLYAFVVVYGLVGGAAQSVIPATATTMTPDINRTGTRLGMIMSIVGFATLTGPAIEGALIATDGGRYVAAQIFAGVSILLGVCAVAAARVAKAGWGLDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKS5</accession>
    <name>A0A370PKS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_292972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKS5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016828261" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56029" checksum="40109941A154BC21" modified="2018-11-07" version="1">MRHFRSYNAANLLTLFLGAKAAAESTWPQQTFRSTSIQAPYLNVTKNGKTELGHLFFSPSSSTMEWSYPAIYSDDGQLVWQGPNANTSAYQPQMLGGEPVLAYWQGANYQGYGFGAISILNASYQEIHRITLPGTEQHFVTTADPETFPSYIDIHESQITSDGTILVTAVNVTQFDLSPIGGPKDGWVQDGLFYEIDIKTNKVLFRWSTVEHLSEIPLTDTELPLLGSGTSKSDPYEYPHLNSVAKYGDSYLLSSRFLCSIFLLDKNGNVTWQLHGQKGASFTLTPGSSFCYQHDPRFVNYSPNATSLILHLHNNENANVFTSPTTITTGLILTLDMQNRTVTPVRKLWNSDAPLFAVSQGSFQPLPNGHVLLQHGAMPVLEEYDENGALVMNARFGFDESTQSYRGYRFREWVGKPTTRPEAVACREGGSDAVVVYVSWNGATDVRGWKVRMGDELAVVGDVRDKNGFETRIVLEGVEGRDGEKVVVQAVGGVGDGVQSSVVKVGEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLH8</accession>
    <name>A0A370PLH8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_276139</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="243"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="464" mass="51762" checksum="6A3CB8A440B6D099" modified="2018-11-07" version="1">MSTLEDLDDLEREQRDKKKDQGDDGDGRKPEGEGDADMKDADAKRDEDDGLLDEEILSSSTADIVKRRRMLENELRIMKSEYQRLTHEQNTMREKVKDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIYLPLIGLVDHEKLKPGDLIGVNKDSYLVLDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEADRFKKLGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMAVDDRVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGMSKVGHENYVDAISEVQAKKKDTNMGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT5</accession>
    <name>A0A370PLT5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_232622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLT5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="57396" checksum="F0DA56E808221E9C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM86</accession>
    <name>A0A370PM86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_315521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM86"/>
    <dbReference type="SMR" id="A0A370PM86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016704774" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="423" mass="45904" checksum="1AD372EC2DC16AA5" modified="2018-11-07" version="1">MQLRASVLLSFLGLASVGHAGNVENNHNVCTVRANGGHQDDVPNIMAAFKECGNGGTIIFPEDQSYWIATRLHPTLKDVAIEWRGKWTFSDNLTYWRNNSYPIAFQNHHAGFIISGDNITINGYGTGGIDGNGNTWYTAEKGDTQPGRPMPFVFWNVSEVIVDSFYVKDPPLWSVNIMNGTNMRFNNIYCNATAVDAPWGDNWVQNTDGFDTMDATNIQLTNFVYQGGDDCIAIKPRSYNIDIQNVTCRGGNGIAIGSLGQYLEDSSVANIRVDKVNIIRYNEDMHNSAYLKTWVGALVPQSSYESAGVPRGDGWGSIRNVLFSNFNVQGASAGPSISQDSGDNGSYAGTSKMSISNVAFVNFTGWVDTEKSVVSTVSCSEVHPCYNIDYDNVVLYPGKNATTAGTGSCKYTADGGVHGLSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM90</accession>
    <name>A0A370PM90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_155679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM90"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="21722" checksum="5BAFEB1AF1E305C2" modified="2018-11-07" version="1">MVLLIVGFCRHQVRYAAQEIPAAKSARARGSYLRVSFKNTRETAQAINGMKLQRALTFLNNVTEKAEAVPMRRYAGSTGRCAQGKQWGVSKARWPVKSAEFLLDLLKNAEANADTKGLDTGNLVVKHIQVNQAPKGRRRTYRAHGRINPYMTNPCHIELILTEGEETVAKGPAVKEVRLSSRQRGAQLRRALIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMT1</accession>
    <name>A0A370PMT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_250278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMT1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="29864" checksum="4E2AB6C2C26746A2" modified="2018-11-07" version="1">MTDPNKGTKITLYWLSQSRSHRILWLLEALHLNYELKIYHRGPDKLAPPELKEIHPLGKSPLLTIQPANATPDQKPLVLAESGIIIEYLLDHFGSNAEKPLLPPRWKDTQDGVVGGETEEWMRYRYFMHYAEGSLMPFLVMQLVMDTVKNPPGMPFFVKPLPRLVAGQVEKAFLARNIQSHLEFLEDQLRSSPNGGAYLCGTELTAADIMMSFPVIAMSGRLEEQLDKFPLLKGYADRLEKEEGYIRAVKKVEEVDGKFEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN11</accession>
    <name>A0A370PN11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron permease FTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_275757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26695" checksum="7C41B842FD9499BD" modified="2018-11-07" version="1">MWLEKYVMFILPFITVLREGLEAVVYVGGVGLGLPATSFPLAVVCGLIAGCLVGYLIYRGGSETTMQFFLIVSTCFLYLVAGGLFSRGIWYFQNNAWNNIIGGDASETGSGPGSYDIRQSIWHVNCCNPELGGGGGWGIFNALLGWTNSATYGSVIGYNLFWICVILAYAAMMYRERRGAIPVIDPMIARYQAFKARVIAAILRRPVEEEDVEPVEQSGIFAESGKAKETGVGGPMSVKEAEVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN35</accession>
    <name>A0A370PN35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_335387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="192" mass="21489" checksum="515C58EB0784D932" modified="2018-11-07" version="1">MEQQPLQPQQGELNWRLSAHPITLLFFLGFRIGALLMYLFGVLFIKNFVLVFIITLLILSADFYYLKNIAGRRLVGLRWWNEVNTSSGDSTWVFESSDPTTRTITATDKRFFWLSLYVTPALWIGLAILAIIRLSSVIWLSLVAIALALTITNTVAFSRCDRFSQASTFANSALSGGVMSNLAGGLLGRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN66</accession>
    <name>A0A370PN66_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_233351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN66"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="600" mass="63786" checksum="78136B885FC3839F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP25</accession>
    <name>A0A370PP25_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_249354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP25"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009523" evidence="5">
        <location>
            <begin position="17"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="521" mass="56842" checksum="DF10D9E9FEA4BD4E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP51</accession>
    <name>A0A370PP51_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_275225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP51"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="456"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="688" mass="77611" checksum="87CA214D89F150E8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP53</accession>
    <name>A0A370PP53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_292133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="155" mass="17415" checksum="D4BCF2B55EA528EC" modified="2018-11-07" version="1">MSSPPPSYDLSIQIFGPGEDPHHRSHWGFLIARPSSPTGDLLHVQVIDLDKLWYQFEARINTPLRTMETMMQAVGKVKLATLGSEQQRQQAIEFITASPTPRDGRKRCQDWVFDTLLSLEVEEVVPAGTCHFWEGLVGRSAAEVRERSGVEWAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP55</accession>
    <name>A0A370PP55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_213033</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="25"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="60147" checksum="593DA1127D6CD269" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP73</accession>
    <name>A0A370PP73_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_148403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="420" mass="47432" checksum="63B4E229716D0B73" modified="2018-11-07" version="1">MRATPAVKYPWSKLHLPLPRTPRQSEQLLNAITSSFRRQLDREYPTNNPSTSDRNETSAENSSENPHSSAHATDRLLHNILDNPLFRVAPSASPISSNASGMRDAKQRRMLTEPMVVFDELAAAGHVTKGDLLQCLQYQLMLARGTGDDFVKAMKDSRAGTKVVNWWLASGWRDRLKIFDHRQTSATLVKFMVAEGMQDTVLLWLKMLANTDLRAFNGHISRSLAERVARNLLTDFLAAENQYGGGLASAMRYYVQVGDMYFSMEDLHNRRDTKNLLRHAGKYLFQQVSREVPNDKNMVSATVYEEYARVIATVCTDFVTASVALYHPTVPDPKPFLRYVYNKDMPTLQTWPAGLREVFVRSGSVALRLLMDQGKRGDATWLAGILQHVSDTDKAKVEHEASADEKALLSRLLRVDMAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPL8</accession>
    <name>A0A370PPL8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_152432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="82" mass="9299" checksum="3DBAC2FA245A7B17" modified="2018-11-07" version="1">MHSAVTLLMEVRKISATETCRVLEQLIIDYEQEALRLRDEPLAGHGQSGTLGWHLDRHIWIYSGTVCEAQLVLDIASTHENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPM1</accession>
    <name>A0A370PPM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_292290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="222" mass="24880" checksum="760ED1808ED6EC8E" modified="2018-11-07" version="1">MPSASPSSPFEAGIYLPGGHNTDPPMTTDTDGYRLNHFMLRIRDPQRTLHFYIDLMGMRTIFTMNAGPFTMYYLGYPPTPSDRADLSAWASRVANVRELTQTIGLLEFYHTHGTEKDEEFRVSSGNSPPNLGFGHLGFTVPDVPAAVERLRREGVHVLKDLGNSSRESVPLSTWEEHRGFGTGDVHPKFKDIYDQIACVADPDGYMVELVPQNMQDQWAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPT1</accession>
    <name>A0A370PPT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_313887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPT1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="182" mass="20748" checksum="B336A935F4D91EF5" modified="2018-11-07" version="1">MLRNVVPFPQLQSSSQGYAGLEPYSELTDAYDLRGCFGEMSRMQNGHIPIPLKRPSEEEEDSIDSENTTVQKYNYNHRYRNNSSSSSSSPTNHPPDIEKCQPYRGYRQHDDDDDDDDTEILSNASGDDSINSNGRPKSRVVMLYAACYVAFAILSFFSAAYYFLCWMPYEPSNSNPFPGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPX0</accession>
    <name>A0A370PPX0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_291401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPX0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="382" mass="42502" checksum="CEDDFBBC0BEE3B8B" modified="2018-11-07" version="1">MNARSDSDVPYNGDALIGVSVAIAVVQIVVVVARFYTRRLQQLALALDDYLILLALIASLGQSALYIICKWDISTTARSSTDRWVSFRKVVILAGVGHHMEYVEETPEKLVILEKGLYANEILDFPFTVTPAKISILVFYLRIFTTRSFKNMAYIVGAIVLGHGLGILFAAIFQCWPIAYVWDTTIEGGSCFNQLAFYRYVSPPNILTDVLLLIMPLPYVWKLHTRKGQKLALTGVFLLGSLGTVASILRMTTFFQENATTDPTWTSTNLGIWTILEGGIIIIAACLPPIWPLIMRIIPQQLRSKGSSQTPQCYHRRYPTNQGNAKTPEGFSRLGDNSQSRGSHVPSLGSQTMVARESEYYSENISLEEAMHGYAVRPKEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPX4</accession>
    <name>A0A370PPX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_248241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="45996" checksum="95A72125FC7BE067" modified="2018-11-07" version="1">MNVETSLPGSSGSDLETFHHETKKHANHDSGISVNHEAEIGVNHTFEKPGPVGIRERLRHFTWAWYTLTMSCGGLALLIVNQPHDFKGLKDIARVVYCLNLAFFVIVTSLMAIRFILHKNMWESLGHDREGLFFPTFWLSIATMITGLYKCFGDDANEKFTKCLQVLFWIYCGCTMITAVGQYSFVFATHKYELHTMMPSWILPAFPVMLSGTIASVIGSGQPASDGIPIIIAGITFQGLGFSISFMMYAHYIGRLMEVGLPSPEHRPGMFICVGPPAFTALALVGMAKALPDDFQIVGDPHAVIDGRVMLFLAVSAAIFLWALSFWFFCIAVVAVVRSPPKGFHLNWFAMVFPNTGFTLATITLANMFESPGVKGVATAMSLCVIIMFIFVLVSAIRAVIRKDIMWPGQDEDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ12</accession>
    <name>A0A370PQ12_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_274652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="227" mass="24861" checksum="8BC9F23FA03BA8B7" modified="2018-11-07" version="1">MEPANEDIGSVPPHQPRPSSPTQSSTPPPDIINNGTTAATLSDGVAVSNGSVLPRAQDLSNRDRPVSGIVPPYWSHHRNASRASHLSIDQAPGITLEDHTEDPDCETSRGLWAKSVVVDDHVVVQGKTGIGSYVVWNCRIQTLDGGPITVRLRYSEFDDLRQRLVASFPHAKNALPPLPPKSVIFKFRASFLESRRVGLEYFLNCVLLNPEFSSSPVVKDFLFGRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ16</accession>
    <name>A0A370PQ16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ran exchange factor Prp20/Pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
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    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="86"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="463"/>
            <end position="516"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="525" mass="55503" checksum="80719C174414DB17" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ80</accession>
    <name>A0A370PQ80_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">RINT-1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_232405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINT1_TIP20"/>
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    </dbReference>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="92240" checksum="B5919240FE8B682B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQK3</accession>
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        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_282498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="815" mass="90850" checksum="D9788A6DD8DEDFBE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQT6</accession>
    <name>A0A370PQT6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_318213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQT6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="240" mass="26721" checksum="51D1B536CB4CE391" modified="2018-11-07" version="1">MTGSKNVVFDIVGTLVSYDVLFDAIDTQLGDRLRAEGIKPSLLGYTWIEVAEREYTYLSLSGQYKTFATCLELLFWRMLKMAGIQDPRSFATKSDLEFIMSRYAKLGLRPGAAECVTKLRDAGFTVWALTAGDAARVGGYFANAGLEWPAENLKSCDSQGIGKPDLRVYQPLFEQLSQYGQPWFAAGHMWDVSAARRAGYKGAYCTIWEKEPIVELFGEMEVMAETLPAMADKIISAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR65</accession>
    <name>A0A370PR65_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_143166</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0430">Lectin</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016612872" description="chitinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="42"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="40498" checksum="B38D1A1DBDC2B405" modified="2018-11-07" version="1">MSLFHVLALLVASLSLVTAQTFTNCNPLNETCPADAALGTNHTWYFNTTVDDTIWNVTNGNIGITDEGAEFSIAQKMDSPTMQSNFFIFFGIVESHVKMAKGGGVVSSVVLQSDDLDEIDWEWVGYNTSEVQSNYFGKGNDTSFDRGGFHYVPNADTEFHNYTTYWTSEKVEWWIDQQLVRTLKYEDAVGGKNFPQTPSNIRFGIWPAGDPSQPHGTIVWAGGEIDYSAGPYTMVVQKVRVHDFHTGKEYSYSDHSGSWESIKVVSGNSTTVEQLNKPPPKSLSERWNELPSGAKAGIGIGIAAVGASCLAGFIFFCLKQRKRGRLEHALNDAQWNSERTEMNNFQAEWKQSEWKHKGYQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRD7</accession>
    <name>A0A370PRD7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_127466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRD7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="592" mass="66249" checksum="80DD926C45ED96E2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRY7</accession>
    <name>A0A370PRY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Yippee-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_230490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="249" mass="27641" checksum="E78887454359E53D" modified="2018-11-07" version="1">MHTYPRTSQGRSHIQGSMFPKFLLRPSFFRDKQRSMRSRVSSSEAGPGESVKPSDANYLEGHISCIRCSCCAADICLTSQIISKGFTGRYGRAYLVSGEPSLARKTSPTDTLLNTVIQQPVPRRLVTGAHTVGDINCSVCGNVLGWKYIAAEEESQRYKIGKFILETERVMISSFWESPDVVESTLLPAYPGSTEVGHGQPPNSIEFDSQNEDECEDLFSGIWTPGLAVRRRNRKLPERRSSLFGITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS18</accession>
    <name>A0A370PS18_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF4">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="159"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="55198" checksum="65503CE8DB4FAE94" modified="2018-11-07" version="1">MTAQASHTEMQRASSAVNFRYTHFAMLCIDHNGDLRIEASPSIAGCEKAIFTDDVQDRFLKSVTTAWQPSLQSLHSNTLSHMNGDVTGKPMLLSSPSLGLQHAWYQPSLPRQAGLIPCEWQSLQNKRHRRSLRHELSGIGLDLDSASPTPSLRRTAIRLGQTDLVRRYYEKAFEAFQQLNCRVIAKAFVKLVEPRKQVNHPYNGRRAAGGSSQKMDSELTKPKWWPTGVTHKEPDHLQKAERIRLLVHILCELKESRGITAEKLKDAGQDVRRQIQPESRLQVLDEIYYVRYMEELYMEGKISGDTMIYVSHVHLDEDFLFAEIREQTTNNSRELSLPIMNNKPDAPKGTEGSKSPGDQSEIQAATDKSHTDMPVSSDERRLPPMEVNHQAKRPANQDYCYPPSPVSSPSISRKSSLESGLSTYSTDMAAPMLSGSEPNGAPCASRDIHPAEASCMPDYFGSQQMATSSAEQNHQPGFWSLPPAHTALPFNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSP1</accession>
    <name>A0A370PSP1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_134180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="65" mass="7317" checksum="AF4111B70983E190" modified="2018-11-07" version="1">MYLYSDTVGRVDELIWSRNRQLKHKSGLRSLGDRPCGWAAELTKRAGGDCQSIWTMCESTLGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT94</accession>
    <name>A0A370PT94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_333260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="951"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="229"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="539"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="809"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1391" mass="155098" checksum="43A5A03251025954" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU19</accession>
    <name>A0A370PU19_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_324516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="476"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="73487" checksum="A5E031CADB8127DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUF0</accession>
    <name>A0A370PUF0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_290419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="662" mass="73473" checksum="04DDE827A89B8B35" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUF9</accession>
    <name>A0A370PUF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_290429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="42871" checksum="B54F1EAB589C5968" modified="2018-11-07" version="1">MPASPKMSADEGSLTGAALGMSPPPSDNGALGDDLPSSFHPWWGPESCVWLLVEEPNDIALDPVEQWRRLSFLLEYGDYAARVWNCLLKVSRALKSPIYKSVVQFRDNLTQELKDSSDETKKRIRLVERCVVYLINQGLDIDLEMVKLAILVYSKRNITCHARIGEISNSAALRREIERANRRLPEVLPSDQSRNYSAWQRILAFYGSSQDFINLKPGTGFGRVLPEPDIRSLPSDARCRAFKNNVFDRRIDATFQAINERIPVTSRPVLGQTRTRHSVSDPLPYIPRKRRAVGSPDSDERNNGKPAASPFPTVAFGNVEDACTYQEIYRDIDYVFGKNQRSSRRALQEARKVVRQARANVDRPRGGGVRRAEWKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUY3</accession>
    <name>A0A370PUY3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_333460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="623" mass="69512" checksum="C137E2DDE218BA16" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUZ6</accession>
    <name>A0A370PUZ6_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_208708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RDK46011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUZ6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="173"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="63250" checksum="7DAB5994D30C811E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV00</accession>
    <name>A0A370PV00_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_323795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="210"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
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        <location>
            <begin position="349"/>
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        </location>
    </feature>
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            <begin position="280"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="407" mass="44975" checksum="833825E6B0653339" modified="2018-11-07" version="1">MLQTRLALTGLRLPFRTLSSAVSSRAYSTVVREQENPSADEPASSTFDPSIAFAPPPTRDDAGILLRSYTPRTPGIRHLRRPINDHLWKGRPVQKLTFPKRGQAKGGRNNSGRVTVRHRGGGHKRRIRMVDFARDAPGPHVVERIEHDPGRSAHIALVRSQETKKLSYILAAEGMRAGDVVHSYMSGIPEELWKSMGGTVDPGVLAARTAWRGNCLPLHMMPVGTLVFNVGLRPGQGGQLCRSAGTFATVIAKGIDIKAKRDHSDGQEGEAGAVEQKPLTQRERQRKERISQHVTIRLQSGEVRLIHKDCCATVGVASNPNHQYRQLGKAGRSRWLNIRPTVRGLAMNAAEHPHGGGRGKSKGNVDPKSPWGMPAKSGYKTRPKWKINKAVVHPRERNQGKRRRGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVE7</accession>
    <name>A0A370PVE7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rRNA processing protein Pwp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_332793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="60086" checksum="3EA6F333E83FFA22" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVG4</accession>
    <name>A0A370PVG4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribonuclease NucA/NucB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_262528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016771091" description="Deoxyribonuclease NucA/NucB domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Deoxyribonuclease NucA/NucB" evidence="3">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="248" mass="27177" checksum="A2698396E4A83ADC" modified="2018-11-07" version="1">MILSSTLLPILTILLSIPNTLAHPTTDDLSLSFQPRSNPGDSKSNPIKGEIEIRGEDALTYDVDCWAMLCKGKSAVMQKVDTDAADVNRQVEAGSAANKQPFKDPTKYGMKASPATNSWGNNKGWVSAEEFPFASTKEGGKDAILVGVTINSQDEQKRSLRSFYQKNKVKSYDSKNKKSNGSWFEITGFKVKSGKNAKVGPYCQAFTDKKPGNVCNANTKVTGAWGFDVAEYAYVYNHSTKKFDYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWC0</accession>
    <name>A0A370PWC0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_246384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="5">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="332"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="674" mass="75490" checksum="63B552C66D1254A4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWG3</accession>
    <name>A0A370PWG3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_290039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWG3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57610" checksum="BBFCE428EB99919B" modified="2018-11-07" version="1">MDDPPKTSTVNSLTGTAGTQPSCSVDELFDFASFTWSPDAGAGWQLNHANMNSELPLTLGQAQVRSSDDVLNALAIDEPVSPTGSPPCHEEGLLAWTASPDNERLMTFFSQSGNPPLLAEVETKKTWVSMRRLVIGMARESKMVQSAVLAFSCILFNRQEGLQADARHYYMSAEAEVLAFDKSSTYSHDGRREHLLVSLFFLTYVDVLQSRLEAAYSHLNCAYSAFQLSCKDRLTFSEKQLFLWFRILDGRCVSSGGDGLFLSHDHDLLTMESSPASFTETEYDQAAEDETEGLLFQILCQSGIIFYQKVLGLMSRVAKIDPWHRSRGTVEDETEVMEVAKQITQDLLALYDSRPPLMDHAVEGRLTDQHLSPNLAFTLTRSFRTYLANYYATKIHLHRVAYKTLPLTKDALEALEWIRMLLHQLIDALRPDDVLPINMMWPLLMLGAEVPDPEEKRWTRNQILQTEKVASNARITAQVLEVVQSRQDSTGTRMDIREAMYEVFNATFPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWN1</accession>
    <name>A0A370PWN1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_324028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWN1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="156"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="33148" checksum="E85B8F64B191EA21" modified="2018-11-07" version="1">MTTKIYHTNNLTISLSHHPTTPGHTIATLTNTTTPKTTLFALPKSTFISTLVTLRTIIPSLKSTYHTPRIALITSGNTTLSLLPLHGLTSTWTPITSPETTFNDPQSSSHPQSYITSKSGPRMPSAHLSHIADTITTHTSSTPNYTFHGPSSDTNLFANIIRGTEHPQWRIWEDESHVAFLTPYPNTPGFTVLVPRTHLGSDIFALGEEDFEGLMGAAWTVGRVLMEALGVGRCGMVFEGLEVDYAHVKLVPVYGDGEDDGGEREVFREVYPGYVSSLPGPEVGDVGELVRRAGEIRQLIAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXY3</accession>
    <name>A0A370PXY3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho guanyl nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_68924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000041">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="178"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="826"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="924" mass="104407" checksum="75A8BF3A14B9DA3F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY04</accession>
    <name>A0A370PY04_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="206" mass="22881" checksum="5E6D3501DB5C800F" modified="2018-11-07" version="1">MVPKQRKQARQQTSQQKPQARPSSTSHDIDLPSIPIQVYEATAPGTVVVLPKLSGEDQQVQLPIWSSISRWEACQQLDPDPRRPSTTRTSSDSLLSPTETGFNAVPPRSGRHCWLLICTSSAPRITRHSTTHSISHDSDSFGTPDTAEANALRPPACHIPDLLFVYRRKLPGFPTCLGTPPSSYFPFLNGQILFTHQSDEDLNTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY29</accession>
    <name>A0A370PY29_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_228081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000406">
        <property type="entry name" value="Putative RNA polymerase II transcription factor related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="629" mass="69574" checksum="423B8BA62B823D3F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYD8</accession>
    <name>A0A370PYD8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_228284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="541" mass="59326" checksum="609423B0ECCC4A08" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYH8</accession>
    <name>A0A370PYH8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">M752DRAFT_245486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYH8"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="99"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="801" mass="89065" checksum="CCB2B62E1FF5AA5A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYI5</accession>
    <name>A0A370PYI5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016485703" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="59427" checksum="AFACF7E791EA2586" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ00</accession>
    <name>A0A370PZ00_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_243685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016481659" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="24"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="648" mass="71873" checksum="6934F568B65C1010" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ36</accession>
    <name>A0A370PZ36_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_260821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="209"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="33184" checksum="43E8734DB452FD03" modified="2018-11-07" version="1">MASPEQIPGQEYDYEALPSNYGLGRNMLAGAFAGIAEHSVMYPVDLLKTRMQILHPSNGGLYTGLTNAVSTIYRIEGWRTLWKGVSSVIVGAGPAHAVYFGTYEVVKEMAGGNVDDGHHPVAAALSGASATIASDALMNPFDVIKQRMQVHGSVHKSILQCARSVYKTEGLQAFYVSYPTTLCMTVPFTATQFVAYESISKVMNPSQDYDPFTHCMAGGLAGAFAAGITTPLDVVKTLLQTRGLAQNEEIRSAKGLFNAAAIIKRQFGWKGFLRGARPRIISTMPSTAICWTSYEMAKAYFKGQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZC5</accession>
    <name>A0A370PZC5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="330" mass="37103" checksum="0E76071EC9C4008A" modified="2018-11-07" version="1">MPFEKLRENTLPVADTQDSRGQKTILNLMSNLHLSSEYSDLKIICKDKIFPAHKLLVCPRSKYFHRACFAGFKETKGSICLDDKSPVLIEKVLEFLYTGNYTLGYRTTKTLTPPTDDNEGPRMNTNHTRDPLIYFPSRRRATDEYAAEMEELANDAAVAAVENSADGFVDGSPMNKKGPNEEENNVEPAVDILADCHPCYFHVRMYGEADYFMIDDLKIKAEEKVLASLVNCSEVDSFSQIIAELYSGRADYGRLRKLALKVIVDNLPTLRKGFTPVINAKLMESVPDFAVDLCLPTIDKYVGEPHMRPNPFPTGIEYKGVIYTVHSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZG9</accession>
    <name>A0A370PZG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_288070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="369" mass="41181" checksum="34409F5A184BC960" modified="2018-11-07" version="1">MCSKLFQPLQIGKANLEHRVVMAPLTRFRADSQHVPLPMATTYYEQRASVPGTLLIAEATLISPSAGGVPHAPGVWSEEQVHGWKKITEAVHKKGSFIFCQLIAAGRAADPAQLHAEGGFMLHAPSPIPIEPGMPVPKELDEIEVQEIINDFAMASKNAIRAGFDGVEIHGANGYLVDQFLQDVSNKRNDKWGGSIPNRARFGFEVAKAVADAIGADRLGFRLSPWNTWQSMKMVDPVPQFTYFVERLQQLGLAYLHVIESRVINNVDCEKEGSIKFLLDVWGKSAPVIVAGGYRPENVENALEEEYKDYKVAVAFGRHFIANPDLPFRIRHDVHLNPYDRESFYTPLQENGYTDYPFSAEFIESKTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZP4</accession>
    <name>A0A370PZP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_332597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="148"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="60289" checksum="747826A949B4CE8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZV9</accession>
    <name>A0A370PZV9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">M752DRAFT_261076</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="606"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="1141"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="29">
        <location>
            <begin position="1398"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1890"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="1898"/>
            <end position="1908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2259" mass="248331" checksum="E7D0087A8CA85D5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0B3</accession>
    <name>A0A370Q0B3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chimaerin and related Rho GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_7307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="LIM2_Rga"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho GTPase activator Rga"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="899"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="690"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="329"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="378"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="416"/>
        </location>
    </feature>
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        </location>
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            <end position="451"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120300" checksum="AF622434EC6C14D4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0B8</accession>
    <name>A0A370Q0B8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannosylphosphate transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">M752DRAFT_261221</name>
    </gene>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016777853" evidence="5">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="33753" checksum="FD22EDC2579ED355" modified="2018-11-07" version="1">MNPRGLLAVLTCAIWSAVATARPSPAEHSNHGSFVNRNDPDPLWQKYGLNKSDEFKYFHEPGRDDTLGHYDSRFFQGEPVPDAERSITLTHMIRAYLNFFEDNGLETWIAHGTLLGWWWNGKIMPWDWDIDTQVMDTTLFHLADHFNQTVVQYTTTDPDVERRYLLDINPWARQRDRGMGLNIIDARWIDISTGLYIDITGLSRLTAEKPTEWECKNGHKYQTHDIYPLRRSTFEGVPAKVPFRYDGVLTEEYTKKALTNTQFHNHTWDAELEEWVLDVPAAMDDRQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Z4</accession>
    <name>A0A370Q0Z4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Z4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000093">
        <property type="entry name" value="BZIP transcription factor (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="60780" checksum="2C8CEC9AD22F0E8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q143</accession>
    <name>A0A370Q143_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA splicing factor Clf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_11774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q143"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="74654" checksum="2E68B18443C1BB93" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Y8</accession>
    <name>A0A370P4Y8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_259776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Y8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="54"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="49637" checksum="B25F2303A5F1D919" modified="2018-11-07" version="1">MAPTTRDLESLAVHHDSDIMADDLAEKKVSANESPPENDPFGNEECGEVKYRVMKWWHCGILMIAENISLGILSLPSAVATLGIVPSIFLILGLSGISWYTGYVIGQFKLRYPQVHSMGDAGEILFGRIGREILFFGQLLFCIFLMSSHILTFTVLFNTITGHGTCTIVFGVVGLVVSFIGALPRTMGKVYWMSLASCTSITVATIVTMVAIAVQAPDHVQVDITTHPSFSTAFLSVTNIVFAFIAHVAFFGFASEMEDPRDFPKSLAMLQVTDTTMYIVTAMVIYRYAGPDVASPALSSAGPLMSKVAYGLAIPTVIIAGVVFGHVASKYIYVRVWRGSPQMHTNSLAAVGSWVAIALGVWVIAWIIAESIPVFNDLLSLISSLFGSWFSYGLPAMFWLVMNRGQYTASPRKIFLTIVNLVIFGIACAICGLGLYVSGKAIHDSSSSASWTCANNAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P528</accession>
    <name>A0A370P528_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_287325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P528"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="40345" checksum="E01CDF4FD5EC8374" modified="2018-11-07" version="1">MASQQVTKTPFQKILDPTKIGTWNIVRRPPVENHSIIQGKPREQNSNAFKTHQAKEGTRLRKALKALTHGKNIFAYHNIRTNQVVYSLTRYLENNTTLKQLLYHGKKTVPARLRKDMWVPYFSVHFNDSKIGLRAYHLLREFSMQRQLSPPKEMITITDAWIDQKRPRDPKGAEDFLEKYKDKIGRIMPKHHRKRAVMDQKATSVADIAAVLKIQEEEVQNGFANGKRGYLTPTARKRRRAARAKEEQVAAEQAARVAGLEQALSSEVVEYKVQETADTTGALEDQGVKILWRDLHDARFAEAWPERVRHGELELSRDHVMPGQKGVRSEVLAEGEFRERTEQQQQGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5L4</accession>
    <name>A0A370P5L4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_310298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5L4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984822" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="137" mass="15272" checksum="7EEB5503D1E08FCA" modified="2018-11-07" version="1">MFQLKTILLSLPLLLTTTLAAPSTSLDTRSDSKCVYYCGSHCYWASDISKAQAKGYSLHEEGRTIDDYPHVYHDYEGFDFTVSGTYYEYPILDDYKVYDGGSPGADRIIFNGEDEFAGLITHTGAEEYDGFVACEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P613</accession>
    <name>A0A370P613_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_287207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P613"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="71613" checksum="A4168BB83BABB725" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P618</accession>
    <name>A0A370P618_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_279815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P618"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="741" mass="83390" checksum="7512733EA6E2D57B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P668</accession>
    <name>A0A370P668_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_241796</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P668"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="147"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="62716" checksum="42F008E70AF822C8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6T7</accession>
    <name>A0A370P6T7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_308978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6T7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="43"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="434" mass="46607" checksum="289BE46A6C97E00C" modified="2018-11-07" version="1">MSHDQRSPSEEVSRTALSKPASESTIVGDGHHPLPAKDTSTRAWLVVVGGLLIYFPTFGFLNAFGTFQTFYVQDLLAGTSSSKIAWIGSLQIFLLFIGGLVVGPLYDKVGATKLLVPGSVVYVVALMLTSVCKKYYQLILAQGILFGCANALLFYPTIAAINQWFDRRRGIALGLAVSGSSLGGIFWTEIIQLMLDHIGFGWTVRACGFISLAFLVPSCVLITTRPPEPGESKDMQLDFKAIFTDAKYLLFSVGMLLVLWGMFIPFFYLPSYGETYGMSVTGANNLLAYMNAGSFVGRVLTGLMADRLGRFNVISLAALSCGILLFCLHKITTSGAIIAFSTLYGICSGGLISLQSACIGQITPDHSIIGVKIGLMMGFCSVGGLTGSPIAGALLSADHQKWYGFIDFCGSILMGGAVVTILSRYVAAPREWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6X0</accession>
    <name>A0A370P6X0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_339623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6X0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="44"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="610" mass="66514" checksum="61551CF3818EEB5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7H5</accession>
    <name>A0A370P7H5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">M752DRAFT_339111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7H5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="182" mass="20008" checksum="D133DBAA6FE49E95" modified="2018-11-07" version="1">MLPSMRLTSRLGLRLVRWNSTAGPTLPPLMTALRTDLKTAMRAKDTPRLNVLRALISETNNAAKTNSPIQTDLQLLSLIRKRISASRDAAKEFEAENRPDLKETEDRHIAILEEYGAQVETMSVDDIKTIVAEELTKLKETGKKVEVGFLLKSLFSPGGALDGKPAERSEVARIAKEAVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7I8</accession>
    <name>A0A370P7I8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_297530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7I8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113023" checksum="9483EE7383951FF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N7</accession>
    <name>A0A370P7N7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_339146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7N7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="354" mass="38138" checksum="46F41690E62C9701" modified="2018-11-07" version="1">MKEIINLPGPSTKLIDSPIPSINDDQVLIKVVVSGSNPKDWKVAELANDPNSFLYSRYSHVRDGVNQGDDIAGVVEKVGKNVVEFKEGDRVAAFHEMLKPGGSYAEYAVAWAHTTFHLPESVSFEEAATIPLAALTAVISLHHHHALPTPWSPPSATTTPTPFVIYGGSTAVGSFAIKLLRASNIHPIIAIAGGGSPYVQSLLDLSKGDTVIDYRNGTDSTIAAIKSLNLNIKNALDTIVDETSAHVLTQVVTPGGQVDHVLPRDPKDLPGLLSTNTWVNAAHEKANGVDDCRDLCFVFCRWFSRALKDGRFKGHPFEVRENGLEGVKGAMKDLMDGKASAVKYVFRIAETPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8C6</accession>
    <name>A0A370P8C6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_308147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8C6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="57065" checksum="0AE09ECA67EFF1E8" modified="2018-11-07" version="1">MASPAVDYDVLIVGAGISGINAAYRLQTELPDLTFTILEGRATLGGTWDFFRYPGIRSDSDLFTFCFPWHAWDQAYPIADGATILQYIQQAASKHGIDRRIEFQHRVTRASWSSSDQVWHLTVDAPEDTSIYRSRFLILGTGFYNYSQALKTDIPGLQQFQGTVVHPQFWPDGLDYRDQKIVVIGSGATAITMIPKLAEKAAHTTMLQRSPTYIVSMPNRQIPSASSWLARWLPRPRFYWVQRFLSLVYTRLFILFCERWPHLARAYLRSHVRRQLPPAVAYDPHFAPLYAPMEQRLCVSPDADFFRSLHTGHVGVVTDTIETCTTTGIQLRSGQHLDADLIITATGLQMQFAGGALLDIDGVPVDLSSKFIWNGMMLQDVPNAVVVNGYTNASWTLGADATMIAVCRLIKLLHAHGHTVAVPRVDPQGPPLTPRPTFALTSTYIHAAARFMPRVAAEKPWQRRDNYFTDLWFAKYGDLEQGLEFIPGSGFRRSTTGGGEKPKEVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8L2</accession>
    <name>A0A370P8L2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8L2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="60328" checksum="309F6B1190332704" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8W1</accession>
    <name>A0A370P8W1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_76565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8W1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="46874" checksum="339CEEDA268921D4" modified="2018-11-07" version="1">MAPLPAGEVSGWVDSPNDRGTIDIIWGCCLVLSTALWTVLHLNIPAPDDSLWTVLWRKLRWGTFAILAPDMLVGFSAMQYESAQESVRDMHRLGYKEWTLKHAFYANSGGFVLQSTDYPPFPITAASIHYLVETHHIDCPTITAEEIWDKSKADTFAKCVALVQGVWLVVQSIARAVQGLAVSPLELFTIAFVLSTITTYYFWMHKPQSVGVPTVIELKSGSVNGLINSAGEIGVEPFRETPLDFLEKPHQRWHRRPTLENLRPQKSPLQRMPDDKIVFNGLSQRTWILVSIQAMVHPAVHLLGWNHVFPTSTEQLMWRIMSVFLASGLPLSSMLRITLTALGFDGHQSLTWIWVQPSGQEEKGWRAWVLDVVMSFISACLVPARLFIIIEAFISLRQLPSSSYVTVEWTSFIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P999</accession>
    <name>A0A370P999_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_306770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P999"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="495" mass="54741" checksum="9CD635EE12F28AA1" modified="2018-11-07" version="1">MSKPTEAFTEYHEDATKIQESNQDAIYQTYVAKSPEWHREMTKKLLRKVDIHLLPFLVVMYLLNFLDRNNLSQARLGSLEQDLGMKGTDYNLATSILFVGYLLMQLPSNLLLTRVRPSLFLGTSMAIWGVISACQAATQSFTGLVLARFFLGFVEAPFFPGAIMLMSSWYTRQELSHRIAWFYAGSSLANAFGGLIGAGVLGNLDGAHGIAGWRWLFIIEGCITVGISLTSTLLLPNYPATTSWLDETEKLYAQWRLIHDAGEADEAKSTNIKEALYLVFSDKRIYLFILLQHTSLLSQNFQYFFPTIVETLGYGNIETLLITAPVWIATFLVSLFVTWTSGKTNDRGIHIILLMLVSVVGCIICTATTNIGARFFGMFLMPMGAVSAYQIIIAWVANSFPRPLVKRSAAIATANMIGNTASIYGSYMWPSSSGPRYIAGGSATAGIALLVAMIAFVIRVVHVRMNKALDAAEEDRGGAEVDNLEARNAGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9B7</accession>
    <name>A0A370P9B7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_256407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9B7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="332" mass="36106" checksum="0EC74AD92D12A18F" modified="2018-11-07" version="1">MALTYDVFRGSPEGKIVTDKVSSDLGYNEVFIETLVSGVCGTDEHYLKSDQVLGHEGVGIIKAAGPGVRTVKIGDRVGFGFTHGICARCDNCARDMDQYCREKKQYGTNDFNNGSFSYGAIWDANCVFPIPDEIESTHAAPLMCAGATVWTVLTRFDMRPGDRVGIQGVGGLGHLAIKLAAAMGYHVVVLSSSEAKRQEAMEYGASEYHVFRAESPLRSFKPLKHLLLCGSGGVKYSSILPLMDSPSAIYPLTATFEPSPIPTLELCFKGCKIQGSLVASRQSTQALLEFAAKKQIYPTIMTFPFTSAGIEEAMSELRDGKVRYRAVLVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9L9</accession>
    <name>A0A370P9L9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_256589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9L9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="61279" checksum="9C9A9630A8FBAB8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAY7</accession>
    <name>A0A370PAY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_238663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="252" mass="29026" checksum="314E17033C626E04" modified="2018-11-07" version="1">MARNSEKAQSMLFRFRAQQAADLGIIDIGRTRRPKAITTVDSIPMCEKWRGQVLKEISRKVSRIQELSLSDYQIRDLNDEINKLMKEKWTWEMQIRNLGGPNYMRGSGRVFDDDGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGRRPAEEEDEEGGKGRGGEIATKKVDANYFGYGLDEEDGVLLAYEKQKEKEAVERLRRKDEDVEDGWEPLPGDAGDGVEWRLPTLDEVQEELVDRRRRRLLDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBX1</accession>
    <name>A0A370PBX1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_304891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="320" mass="35869" checksum="5BE5B29DABA9DBEF" modified="2018-11-07" version="1">MSSSPSGSCAKCGKHTSLQCAGCKGAPEYFPGDVKSIFYCSTACQSAHRMIHKPDCISMTCRKKLLRTAIVAKEAFLVYRAVEYDLELSKIERRGDTLYLSDNQKNLDIPPRRGPFPEHLTADPVYREAALTWFQCDAAHALSSRLISKFLADVPCAIEMFSLRIGKPHFITQVIPGPDSPNIPSLDASTMPHSVLKVDLQLSSFTESWIVDLIGAQYGFQEVLVPFLKYMENKECELVDPPESFDITQTHDLDILMKEYPSGVRRAIACAERPARLRFAAFVDTIDKKILEGSLGEFENKLSVFRLALRQHMSNNTQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC72</accession>
    <name>A0A370PC72_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_268814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000005">
        <property type="entry name" value="Mitotic spindle checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="277" mass="30706" checksum="932F02E26CE88623" modified="2018-11-07" version="1">MTTFSAPVTAPRSMPNNQSALAASFTNFLTVSIHQILFLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIIISSLRTNQPLERYAFDLSGFPRVPAGEVNTTFEDRREEQTKAGVPVTDRASAPTSVDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTTEEQTWIVAEPDKVHLRSCTAPYSVSKLRNGEPQQPPPKVSNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPVDSEHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCE7</accession>
    <name>A0A370PCE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_255307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF112">
        <property type="entry name" value="DUF821 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G14740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="167"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="442" mass="50242" checksum="E08E0250EB77CF86" modified="2018-11-07" version="1">MQLLQCQSSGFRFIATGAILSLIITTFLIFSTQYSNDVAKYALKSSLKTAPQTCLNTSPSEASNATTWEFVVERDGDNHGLSDEQCRLAFPKLFVELDKSASLREGHRITFKELDNLQVEDGMVRGIVHHGELYVVDFGAMPATFTRGKATLHALHRALASFPDRSSLPDIEFVLTTEDYSTNEGPVWSYSKRDEQQNVWLMPDFGYWSWPEVKIGPYKDIRRRIAAVDDGEVTIDGGSTPGLPFQDKKKQLAWRGSVATNPEIRGKLLKAAQGRSWASIRVIDWDDENDVRFNLLPMEDYCQYMFLAHAEGRSFSGRGKYLLNCRSVVVSHKLVWREAHHAALIASGPEANYVEVERDFSDLDRKMEFLIDNPETAQRIAENSVKTFRDRYLTPAAESCYWRQLIQQYAASCEFEPILYTQENGKRQPRGVPFESWVLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCF0</accession>
    <name>A0A370PCF0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_45428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016713159" evidence="2">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="28913" checksum="22E9E58858B10BC6" modified="2018-11-07" version="1">MASLSLVLRLCLLLLLLLLFPRSSFPLLLQLPSIPSSNATCLIAGWGPTLYFFGDSSDIARAKCPFLLCPFFTSSSLSFFFFVFFFFFYTHTHTHTHSLSLSLHRQSRDILPRFSWLVFDKLDDFPYSAPSSPILPALLRRFSCCSCRGLVNFGLQCPQTLGFPPPHSWLCSSSPTIYSTIIYLLPAIITPTYPNPPVHPITPPPPSPPTFYLPSLSLSLSLPPADSLGFFLPTLYFVFFFQPTDHDLSPFAKVSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCU7</accession>
    <name>A0A370PCU7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxypeptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_219450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794065" evidence="7">
        <location>
            <begin position="27"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="650" mass="71574" checksum="CC4933B142A7C303" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDA9</accession>
    <name>A0A370PDA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_39847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="77"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="257"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK40180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="43324" checksum="99F4111838D20750" modified="2018-11-07" version="1">MSLPELNDSPLPKDSHQYDPVMQSEPEPDSPAVSSSPNRPRTLRQRISAAVAKSGSKPLLCFLPLGLVADVLHWNPVLVSIYNFLAVIPLSVVVSDCSDELSDSLGQLMGGLINATFGNCVELSTGILALTRGEIYFAQSVMIGSILSDLLLILGCCLVAASYNTYILHFNKPVTGALASLMVVTSVGLILPSVLYSTFPFDLGDQIVAFSRGTSAVLLALYGGYLYFQLGTHSHLFLQGETESNSSRESQRSMEWLTTTLILSALAIVVCTKNIMDSIPATAATLNISKTFIATILIPIISNSCEGAVVITACGGGGDVNFAISMIVSSILQIGLFAIPFLVMLGWVMGTPMTLYFETFHTVVLFFSVLLVNCILQDGKYTYIHGSMLVAMYAILTLAFYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDH5</accession>
    <name>A0A370PDH5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDH5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="15627" checksum="1BDF454DA8A1B193" modified="2018-11-07" version="1">MRTSQCPPNGRDSPAQTNTQHASFAVAFSLEDIVELVVGDEHAGSERATRKAVLDQCIQTLGQLREDMRAAANKGARLVEAIQFMEDIKGWDTGEAGVCTIREQALRGKPNFIGEFTGMPRSSRREYTRKQANFIPRYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDL4</accession>
    <name>A0A370PDL4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_303842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="754" mass="82230" checksum="26FA94E68FF72AEF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDT9</accession>
    <name>A0A370PDT9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_218894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="629" mass="71021" checksum="ED14CC4DD0236B31" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE43</accession>
    <name>A0A370PE43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_43898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11126" checksum="6B46B1CABB096C30" modified="2018-11-07" version="1">MSIKLLRGATLPPVVAPHRHLRLSLHRPYSSSSSLFSPSSSSSSSSSSSQSSNNPTQYSRSNFKVLPFVALFALGTGSYVLLVKSRTGVHKPKPGSNCMSLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE69</accession>
    <name>A0A370PE69_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_277573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF6">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="181"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="350" mass="38364" checksum="F155A980B200C98B" modified="2018-11-07" version="1">MQAVVFKGLFEVALEERPIPQIQDPTDVIVKVRYTALCGSELHVFRGHQPSTAGFIMGHEFTGEIVETGSEVRNFHTGDLIVSPFTVSCGECFYCVRGCSSRCAKCLLYGCPILDGGQADYVRVPLADSTLVAAPKDIDEKKLVLMADIFPTGYYAANNAFKGMDDATVQESTVILFGCGPVGICALISALEYRPKHLIAIDSVPDRLDLAGRLGAEPWNFQTQADGLRERVKELTEGRGADVAIEVVGHSSALAMAFEMLRPWGRISSVGVHNGEIPWTGFQAFSKNLQIEMGRCPVRSTFEDALKLLVQKQDTLDFMVTDVRPLSTAVTAYDDFNHMRSQKIIFEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEL6</accession>
    <name>A0A370PEL6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_303311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="512" mass="55929" checksum="A11EA82943ED0039" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF57</accession>
    <name>A0A370PF57_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_218442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="620" mass="69497" checksum="1EA9CD9A2C90C3AF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE0</accession>
    <name>A0A370PFE0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_319776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="11"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE0"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
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            <end position="23"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40906.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="857" mass="91915" checksum="1C48B129D0632592" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFW6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_336920</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="300" mass="32573" checksum="2103591E0AE0818F" modified="2018-11-07" version="1">MHAEMKQEIEDKTLELINVVWPISAQEGQNSTNLRQVIRYVSSLLRPGDEDELLPSRSIPSPTYNTVDMPSPAYPSYMERDGAKHTTTRAKSPLDRVDGLQTGQVETDFLNMAVSPSDLAAIFPEDFYGNLLNDNLNLASQNSQPQGFGTLMTMADITEDSGLDSLMPGDDLSLISHLTPQLDISMSMNLQPYTSSEFWEAWLAELLPMACPDSPAGLGAPITDLSNDFPQSLNGLVSVTPELHDHLDESEVSAGLSASSAPTSTSIATNVDDIATGLKDKDAESEVFEQIFKLGSFQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG20</accession>
    <name>A0A370PG20_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">M752DRAFT_319873</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="643" mass="68751" checksum="F2B17EC87984773B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG47</accession>
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        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
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    <dbReference type="EMBL" id="KZ851856">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF11">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="355" mass="39609" checksum="0D4080ED829F73C9" modified="2018-11-07" version="1">MPIQKLKVGMAGLGRIGKVHVHNFLHQTPRAEVVAAFSPDPAEITWGRQHLEPYGVTLYDNYDKMLEHPGLQAVVIGTATSVHAEETMKAIDRDLHVLCEKPLSIDVEVCRAVAQKAKTKPHLKVMCGFSRRFDDSYREVYDKISQGMIGRPSIVRSQTCDKYDPSGFYVAYAAWSGGVFVDMSVHDIDLTLWFMGEDSVPKSISAHGITAVQPELKKYNDYDNAVGIVEFHNGKIAYYYCSRMMPHGQEDTTEVIGTEGKLSVNINPQRNFVNYYHNGGITREVPANFHGRFGGAFVNEANEFTACCLDNKPLPLKLSNAVKAVEIGAYLQEALVTGKQIHFDEIGRRIEKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGA7</accession>
    <name>A0A370PGA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_217720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="119"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="32930" checksum="9E9D3C2C78A5C07B" modified="2018-11-07" version="1">MDSNARAYIPLDEDSPKDLFKKATDFYNIIQEKLKDKGNEGTAIISDTLTRHLGTVIFGSNYIERAGLNLEETIKICEIIFRGEFTPASHIIRSRREVVQHALALNFLINEMVVKDKPLSEDLILRTHRILTEYIDTAGGIPWMEYSGRYRNVHVHAGNTNFVAPNYVPAKMRELVADFERDVHKIESTRVLDPFTLAAKYCNDFVMIHPFADGNGRMCRLIMNAILLKYAGIVVCLGEHDESRRQYIDIQKRAGERMEGSGELAALILKKSIARYRTIKQKISGKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGC9</accession>
    <name>A0A370PGC9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_277209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGC9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="134" mass="15021" checksum="4061FDF64CE57BAD" modified="2018-11-07" version="1">MAVRNSSLASSRRKSRAAHFNAPSSERRVILSAPLSSELRAKYNVRSMPIRKDDEVMVVRGSNKGREGKVTSVYRLKWAIHVERISRDKSNGQSVPIPLHPSKVVIKKLHLDKDREAILERVGKGREAVKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGM0</accession>
    <name>A0A370PGM0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_301722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGM0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016760784" evidence="6">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="45935" checksum="129132FC8CFD2159" modified="2018-11-07" version="1" fragment="single">MAPHSLNIAIIGSGLAGCLAARILREQHTVTIYERDTAKAEAGAAINLGPNAVHILNSVGFDRRRACSIPVTRVLSYNKQGELTRESIHDYVQEFGADWLFHHRVDLRDELLRLATAPSEELGLSGEPAKVRYGARVVGGDVEEGRVILEDGEVVEADLVIGADGIRSIMRGLVVHDDAYITAQPSGSSAFRFTMSREKVIELHNGEVPEIMDSSKPGTLIGVYALDPTERRVIMYPCRNYEILNFAVLAPDNMLKAPASSDSWSAPGDKDEMISLFTDFPDAAENIKLWQLRMQDPLPTYIRGRTVLIGDAAHAMTPHQGQGGCQAIEDAEGFRLFLGNHVTRESIPSILEDFDRVRRPRASQIQLNTSQATARHSAKEIYRFRKFNFTYHGIFEELKRIKTGEECNGHHSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH12</accession>
    <name>A0A370PH12_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_27685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="34506" checksum="BC21F70525429825" modified="2018-11-07" version="1">MLYTKTSRSTPFPNLHQRRKKKKKKKGNANNKAVIKACLGLANVLLVITTFAGAFTLNAYFNITCPDSLAATLLHASSMLFLSAPFGLLIIHLLLFSFPDNAKVPFALFFCIYLQFLITGLALATAVLYLSLAFYYYSNTRLVGIGGIAMIGVMVTVSVFHAAFTTVHLLLSLTHQSKVSRKKDAESRPLGSEGISDTSQRVGSTEEPVEEQKQPVFCFLNLVIRVYESFVKLLMDYFLTMIVSYVESLKSGDKISVYSFYLDYWSWEHQKYTIIFWILLEGSVTCAFIVLSAVELHQVPKACIRPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIB7</accession>
    <name>A0A370PIB7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIB7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="270"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="504" mass="58090" checksum="4C374D3F934E59E7" modified="2018-11-07" version="1">MQNLPAEILGMIGMCIALDIDEDCETERRSTLLALTLCCRKFHKIFEPILYYHLDLGYDHPLTVAHIHLIIRFWKHPEVTDWVRSLKLYWDHDEPIPVHDASNDDFDVFSPFVSQALDKMITPGPRFTDLWEEFRDCLLEFEMEAWIGVLFVSLSRLERIEFDHQDSVLFHDLLYKAAKREQPFHETAPFPFLREVVAHCQDEGQGIHEDFLTPFLYFPNVQSITGYSIWANKSREGRKPYIYSYEPPLPVGPVRQISLDDIWGCTGMLDWLKVCKELEHFSIEASLHPDTRVIERRFDTRKLYQALLPFKDTLKSLSVTYDKQYNICLEMNGGIGVRTDNIPFESFREFSVLEHLTVRHAHLVPISSNAPVKKSSVDRLVDRLPSSLQTLAVQDVLSDNSRLLAELLMVAQDRNSFPHLKSLELRDKPLEDLSASDDETIPDGTTVGGTLTLEMSFAIEEVDKEIEGTDKLRRECEARGIDMQWFMEGETDNEAENGADNAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIT8</accession>
    <name>A0A370PIT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIT8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="499" mass="57823" checksum="E777B6D84AEC9BAC" modified="2018-11-07" version="1">MSLDSCNCLCPPDRPTRELVLCFDGTGNTFRVDGGDSNILKIFRMLDRKKENRYCYYQPGIGEDIRPGTFANAAVRPFSNIAPNAIIDEALATSFAQHVIYGYRFLARRWIPGSHIYLFGFSRGAYTARFLNEMLDFIGLISADNEEIMPLVWEAFTSYKFANSGKESEQAEYFLRMCRDTMCRSVGRVHFLGLFDTVNSVAKFNIYDDHRDMRIQPKPRIMRHAVSIDERRIKFQPVLFERLRAHGKIGRVSTWAERADVEFWGSDLMASPETEFEEVYFAGDHSDVGGGWPRELGRDYVASQIPLMWMVEESIDAGLSYEPEQLHKLGCFDFKKQEQSNPEVIHQAERAILHDSLMYDSGKALETLFWRVLECLPIKRPKVAPDGRVQSTRWHVGGLRRPLPQGAKLHYSVIERLKRDPDYRPYNLGVGNLAEVDDVIEGWKHIVHDKDSGRDKEIEQADEVHEDERSRRRRTLCEYYVWHRDAVDRPRTRRSDLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIZ0</accession>
    <name>A0A370PIZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_252594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIZ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="453" mass="50506" checksum="19607D3104EC1340" modified="2018-11-07" version="1">MAPLNILIVGCGIAGPTLASFLLLADIPAAQKPRITILERESTRNAHLRGQNIDIRGAGVTIIRKLGLEAQIRASTTGEEGVRMVDERNRIWTENPADRTGTIQTGTSDIEILRGKLAELCWKNSQRISAAAERDGAAGIEYIFGDYLDDIQQQGNQVHVRFAKSKETKSFDLLVGADGMQSRTRKMVWGEEGEQERLKRLGMFAGFFSIPREEHDDNWRRWFHAPGRRGIMLRPDGLGVRSTVLMYVVNDKDPRFVEVATNGNGGVQAQKALLEEYFEGAGWECERIIREMKATDDFYYDAVSQVKMDSWSKGRVVLLGDAGYCASPISGLGTTLAFSAAYKLAGYLQPYIKGESTDITEALALYNKEMRPIIEDAQQLAPGMPHLINPETAWGIWTMRSLILALSYTRAFFYIIKLFGRVLHLGPQAADYVPVEDFGFKDLSVWGLQDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJE1</accession>
    <name>A0A370PJE1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJE1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016918463" evidence="6">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="99"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="451" mass="47866" checksum="9E4BB8F1ED6FC6EB" modified="2018-11-07" version="1">MYIPVGTLATASLLAGAALAAPTPSPLKGRNIVRRSGSHTVYKPAAFAAPSHNKASSKYLELSKTKSKGNVNPRSAAYVKRSTSSGSSSLISLFEGEEFATSITIGGDSFDVIVDTGSSDTWVVKTGFTCIDLDTGRETSESSCDFGSTWTVESSFKEIEGEEFAIEYGDGEYLYGVMGNETVTLADITVDQTIGVVTEAAWEGDGTTSGLTGLAYPALTSAYSTTTDEQIVYSNIITTMWEEGLIEPLFSLAIERDVSGAAGYLALGGLPPVDFVEDFTNTSILVTNIEGYSKAYDFYTINIDAITLNGKSLTSAGGDDIQYIVDSGTTLNYYPTSIAEEINAAFSPAATYSDEEGAYIVDCDATPPTHGITISGKTFYINPLDMILDAGTDDEGNTICISGIVDGGSDTSEDLYILGDTFQKNVVTVFDIGATELRFAARENYTSNDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV3</accession>
    <name>A0A370PJV3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_16591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="313" mass="35656" checksum="EB3B28DAEEFF1922" modified="2018-11-07" version="1">MNHYANLPLYNKSTSECHLRDLFWVCYSFDKDICLRIGQPPSINDSDCDLSLPLEYGRMQNINIHRDDLTPDDHTLPLFPWDIRLSIIKSEIYQVLYSTKASFKSASEVLEGIRHLDAVLEHWRLSLDPDIRPLLYYTPNIPVSTVLNTQGVILRLSYYHCVSMIHQASDRHNIPELGAGFESEGIRSSVKITTTASRSTLALLQATIPSLKGECCWVVIFYIITAAQCLFRHILKEPLQFESSQDVEMLHQVPALLGSIPIRHLTPAEIIHLKFMNGFTTELARLGRCAIWKAQRESRGSRDPTPVNQKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG9</accession>
    <name>A0A370PKG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_300599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="36"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="916"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="916"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2879" mass="316129" checksum="630F7F9FF151EEEC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKK5</accession>
    <name>A0A370PKK5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_315057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKK5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="523" mass="58571" checksum="4C18FC8B17ED0F5B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKU6</accession>
    <name>A0A370PKU6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_162189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKU6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="58132" checksum="91536D8A7150814E" modified="2018-11-07" version="1">MGLVQRVTKWLPSTPSLPLDDSSREKGRNLSRFAFFKRRIRLKGNSSISIPLGFVLLFPCLVIVLILLLFVRHPSSPGGILIPAGTPPSIRKISEKYDKVFATGCLPVEKTDAPRANAAFVVLARNKELDGVIQSLKSIERHFNRWFHYPYVFLNDGDFDDAFKATVKNYTSAPVEFGKIDESMWGYPDWVDHEVAKEGVRKQGDAAIMYGGMESYHHMCRFYSGHFYKHPLLMKYEWYWRLEPEIKYFCDITYDPFIKMAEANKTYGFTIAVKELRETVPNIFRYASAYKRKHNLESKGLWEMFLEKPEEEPKPEEEKQEKLPEEILQNEPGENTVPDVDPEAMEGEKYNMCHFWSNFEIARLDFFRSKEYEEFFDMMDKSGGFWMERWGDAPIHSLAAGILLSPSDIHYFRDFGYRHTTIQHCPANAPARQLPRIPWLETTTEDEKERIEEDEYWANPDPVKENGVGCRCRCDTDIVDVEGKQGSCLAEWVEVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL54</accession>
    <name>A0A370PL54_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_233809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08864">
        <property type="entry name" value="SRPBCC_DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="688" mass="75683" checksum="30E36C9A7F63E1FF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL56</accession>
    <name>A0A370PL56_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_233829</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL56"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="42"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="746"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
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            <begin position="526"/>
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        </location>
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        </location>
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        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
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            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
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            <end position="850"/>
        </location>
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        </location>
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            <end position="925"/>
        </location>
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        <location>
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            <end position="958"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="996" mass="110422" checksum="8458351280F7E45C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLA1</accession>
    <name>A0A370PLA1_ASPPH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_293150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLA1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="14535" checksum="4945E3ED4A8422CF" modified="2018-11-07" version="1">MSGCESLPANLRRTKVSQILHGLASDPLTGLLFVAAPCRYPPPFLLLFRIPLRDSSPPAVTPVKVCVPQSQSVVAIFYCWRCTEARYERARRCQTPATITLKLDAFFCDIRRIILRITVPPTGISASKSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLF0</accession>
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        <recommendedName>
            <fullName evidence="8">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_319073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016960977" description="Six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="5">
        <location>
            <begin position="351"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="4">
        <location>
            <begin position="542"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="889"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123182" checksum="A67C0B3537E0DB41" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLI6</accession>
    <name>A0A370PLI6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear localization protein NPL6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_166741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="60126" checksum="72563B87B3623795" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLK2</accession>
    <name>A0A370PLK2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_319101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="658" mass="74238" checksum="E50F8C076B626A94" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM59</accession>
    <name>A0A370PM59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_155179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM59"/>
    <dbReference type="SMR" id="A0A370PM59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="375" mass="43361" checksum="96B95D2B530B1811" modified="2018-11-07" version="1">MFEISRLLHQPITMASPNRNNYSYQGIESYDSGRSRQNSDAMDIHVITAQEPPREPPDNNDPYDGHGGPAGTSHYSKPPNRWLFYEENGRTYHGYRRGVYPLPCDEQEQDRLDIFHKLFTVARMSESLIYAPHPPNGRFLDLGCGTGIWAIDVAHKYPNAFVAGVDLAPIQPPNHPDNCEFYAPFDFEAPWTLGENSWDLIHLQMGCGSVLGWQNLYKRILRHLQPGAWFEQVEIDFEPRCDDRSLNGLALREWYQYLKQATQDTMRPIAHSSRDTIRHLEEAGFTQIDHQMVGLPLNPWHRDEHEQKVARWYNLAISESIETLSLAPFSRIFHWDLDRIRQITAEVKSQAFNKEIHAYNILHIYQARKPGGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMG6</accession>
    <name>A0A370PMG6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_335196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="99"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="559" mass="63768" checksum="6269AC886CD6479E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW5</accession>
    <name>A0A370PMW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_158492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="61" mass="6897" checksum="3B562DF0FF018CF1" modified="2018-11-07" version="1">MTYACRILDKAQKTGGKANEENPKIGATQEKRNAKRGVLCNCWVKQTLGYERLEAQRAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNM9</accession>
    <name>A0A370PNM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_275078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="61073" checksum="04CA70D7A7E353E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP17</accession>
    <name>A0A370PP17_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA exonuclease 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_147258</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP17"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000109">
        <property type="entry name" value="RNA exonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="423"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="656" mass="70963" checksum="53D73188DF82F5BF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPE5</accession>
    <name>A0A370PPE5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_314056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="371"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="643"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="996" mass="112504" checksum="6B10C145395ACE38" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPW5</accession>
    <name>A0A370PPW5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translocation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29881" checksum="44CF1799FDC4F50D" modified="2018-11-07" version="1">MVNWLTLAVPFAYLGVLLGSLATFSSLYRKRKARKSLSLEPWFPPHTQRDIYFSLLHLDPSASNDNKGTGKKPPSSVPDSVLKSALLRRAIEDIKRVMALRTQKGALAMLLQRGSVGDDLWQRFLRAEKEMEDEVRDVVAEANAYVPGWGQTIFQSANEMLNNAIFRERMEKQQAKLEEEKQWWEKRKEGYMKELDVEAEKKEEVEAGEKKAAAAPAAASTTTSEEGSGVPTPATKTPESSGAPPSVAGSDDDAVLVEADEQSAEKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQM1</accession>
    <name>A0A370PQM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_211902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF54">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G04110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="56019" checksum="B9B629903CB65B05" modified="2018-11-07" version="1">MATTTTGQEDLHHEKEVPAVTSDPEAGHEPQLTGKPWMYKPIKIGPWSLPYFASPESQLLLVSFVCFLCPGMFNAVSGLGGGGQLDPTDVSDSNTALYSTFAVVGFFAGSIANRIGLRLTLSIGGFGYFLYVASLLSYNHNKNSGFLIFAGALLGVCGGLLWCAQGAVMMSYPNEKEKGKFIAIFWVIFNLGGVIGSLVPLGQNLHSEAGQVNDGTYIAFMVLMALGFVLAWALSDSKYVKRKDGSHVIVMKNPTWKSEFKGLYDTIRTDYYIILFFPMFLVSNWFTAYQFNSVNGAYFTIRTRALNNLLYWLMQMVGAFVFGQILDLKYLTRPVRAKLGLGLLFALTMGVWGGGYAFQKTYTRKTVEADTDWTTSGYVGPMFLYMFYGFYDAAFQTCAYWFMGSLTNNARKLANFAGFYKGIQSAGAAGMWRMDAVGTPYMTEFASCWGLLAGSLVIAAPVVFLKIKEHTDVEADLNFSDETAQEVGVPLEDHPSEKKQEPEMAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQT8</accession>
    <name>A0A370PQT8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_141788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQT8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="453"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="526"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="802" mass="88497" checksum="817F6BFD083B96DB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW8</accession>
    <name>A0A370PQW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_248736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="228"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="618" mass="70354" checksum="361FBB0E6D9F40D4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRG4</accession>
    <name>A0A370PRG4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_140397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="12408" checksum="83E396B84F6A3BBF" modified="2018-11-07" version="1">MKQKRLAPDELFCPERLTLRLPNCVGSSRRTSDDLCVPIDCEAELTCPHSHVDRKLKWHYHGDDSFWGSLYTGSCFIPFAFPSPHFYLLSCFQPVNFPFLPSPIATPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRJ7</accession>
    <name>A0A370PRJ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_274830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.820:FF:000004">
        <property type="entry name" value="Putative RNA polymerase II subunit B1 CTD phosphatase rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="32624" checksum="378B7633880223A4" modified="2018-11-07" version="1">MSQQQQPLPSSIANRTDVDPRHLAIALHHANQIQAQKDTEVLILDRILRLVELPSSRSADPASPSPDDVRVFKSALVPFQPADYDNLIEERNIEGLCGYGLCPRERRKEDGRGSFRITWGAKGSGRGGRGREMDIVPKEKLEMWCSNECAERAMYIRVQLAEEPVWERRADDARGKHLVLLEEARAKEGKGKMRDPVSIRDVAGQLDSMHLEKLQGPGDMADDIARLSVRDETRSRELAMERGDVHPALYTGRVNIQVQENDNPRGPARAPQMRPGDEKGGSIEGYVPHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRN9</accession>
    <name>A0A370PRN9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_325518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="219" mass="24071" checksum="16F78D2696806916" modified="2018-11-07" version="1">MSSPEVVRQITDLIGVIEQLMAAFDSIKDLSNLPEAFQEASNWLPIVERTLRDVKSSAEKLKSAEDVRALKTALYSCDKKADNLLDIIEQLGEKSKGEYHSSVYQGIVMRQGKQRVETLMDGILESLGALVTHKAFLGEMHNQISLLAKGREDLAGVCPSLADSDLADLPGAANQYGENSRQYNLFGEGTQRIADGHYFEAKGNQNFGILPPKETVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS04</accession>
    <name>A0A370PS04_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion related GTPase srgD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_130360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="30328" checksum="2217A1E02DD50F93" modified="2018-11-07" version="1">MSQPWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSSSHDVTIGVEFGSRIVPVGPPASKALGGEFDGSIRNRAPSITPSPLLPATATTSESVASGLPSPPRRVQELQKRMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRPSTFVSCTQWLHDLRQIAEDGIVIVLVGNKSDLAGDDSRSHQTVTRQEAEEWCRLNNITRYVETSAKSGENVERAFLEVAEMIYRNIEAGKYDLYDRRSGVKGYGATGGSNPGIPNTVTLGLDDAMRKGGSGLGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSA8</accession>
    <name>A0A370PSA8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_317916</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="709"/>
        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="120298" checksum="C18BA0B6DE72A370" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSX7</accession>
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        <submittedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">ATCC 13157</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
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            <end position="92"/>
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    </feature>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="687" mass="74904" checksum="67491AEA54B50618" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT78</accession>
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        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">M752DRAFT_273709</name>
    </gene>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="265"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="385" mass="42525" checksum="8F5F73F1C4EE23E4" modified="2018-11-07" version="1">MAHSKRNTSLPHFTSYERDLLKSSWGTKRGVIGRDSFLPFGSCRLCLHPAREPVVACATNGDLFCRECAISDLLAQRQEIKRLEKERDEAKKRLAEEEERALDEARTRELRDFELVSMGLDAAAKKNNGSSQSQNDESSKKRKADTTEALAAFKAREVEVDGKRKKVFELDDKEMARIAREEQERLKNELKKEKESNKSALPSFWVPSLTPTTDPNEIAANKAIKLTPICPASTDSNRHSYSLKSLVEVHFTEEKASDGSPARVCPSCKKTLTNGLKAMLTKPCGHVICQPCVNKFMTPHDAPDPHASKEEQEQTAALHGRILCYVCETDVTPSNDSNKDSGSGKKKKKDKEGIRPGLVEVSSEGTGFAGRGGNVATKSGVAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTK4</accession>
    <name>A0A370PTK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_311624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="628" mass="71525" checksum="CFDAEED0F9198145" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTR4</accession>
    <name>A0A370PTR4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_311695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17568" checksum="E903CB6E78A857A0" modified="2018-11-07" version="1">MRLCSFSPVQALESLDPGIFMAGQEYCVAGSLSSRGPTVSFSSLTTSTPTITISTFPTLFMISLSPPSSPPLVPYQPQQTGTATNCDRYYLAETGDTCGKIEAQFDVSTSDWNPGVASATDTQWAGWRSDGIRSTRNSLYKCLAMMGTTDWATGLQKNKAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTY3</accession>
    <name>A0A370PTY3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="40669" checksum="3EA00554FE4569F5" modified="2018-11-07" version="1">MATTMAPKTPESPPHRGLLIPEVLERILIHLDIRTLLLSQRVCTAWATIIQESPSLQQALFFAPTQCPKEDIIYNPLLIERFPPFFPNTIHNDLAKPRDCYPPHFLPMQYVGDDCAWSHPVKDDLTRAQVFYSELPLQKYPLRRKAYLHPEASWRRMLTQQPPAPNIPVLRVWSYARYKTFDRYRIPGTLKDVMDLERYVKQNPKDSEPSSPPGDKETNDPENSGVTMGLLFDYVTCDLDLKWWMIMWGDLPPVSMALELGPEYVDAYKRAAKDGSIVILTFQIVQGFEWWYDIAGANAKNLRFRIVDEYRARGWVGERPPTFSNRLRTVEKGSFPHFSTIAPFLARYLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUH8</accession>
    <name>A0A370PUH8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_324649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK45847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="332" mass="35892" checksum="BE1BB7330347F38B" modified="2018-11-07" version="1">MSVTYDVFRGSAEGRIVADKATSTLGHNEVFIETTHSGLCGTDEHYLKTNQVLGHEGIGIVKSLGPGVTSVKVGDRVGFGYTHSICTACDNCATGWDQYCENQKQYGFHDFDNGTFSYGAVWDANCVYPIPDGYDSAYAAPLMCAGATVWTVLSEYGIRSTDRVAVMGIGGLGHVAIKLAAAMGCHVVVLSSSESKRQEAMDFGASEFHVFKSGGAVPEGFKPVKHLLLCGNAGVDYPSLIPLMATHGSIYPLTVAFEPAKVPMLGLVWRGVRIQGSLVASRQSIRSLLEFAARKKIYPTIMTFPLNKEGIEEAMQTLREGKMRYRGVLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUK2</accession>
    <name>A0A370PUK2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_124220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="347"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK45859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="48627" checksum="3B99E53DF4303BC4" modified="2018-11-07" version="1">MPGETNIPPRRDRHVSKVHIADTPITLRNWHKHVNWLNVTMIVLIPLYGCIQALWTPLRLKTAIWAVAYYFFTALGVTAGYHRLWAHRSYTATLPLRITLALAAGGSVQGSARWWARLHRSHHRYTDTERDPYSVHKGIFYAHFGWMILKQNPKRFGRTDISDLNADPVVVWQHRHFLKIVVLMGLVVPMLVAGIWGDWWGGFVYAGILRIFFVQQATFCVNSLAHWLGEQPFDDRNSPRDHVVTALATMGEGYHNFHHEFPSDYRNAIRWYQYDPTKWAIWCWGQMGLARDLKMFRENEIEKGRVQQLQKKVDKKRAELDWGTPLSELPVMEWEEFVERARSRALVVVAGVVHDVEDFVKEHPGGRAMIQAGVGKDATAMFNGGVYYHSNAAHNLLSMMRVAVIRGGSEVEIWKRPQKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV8</accession>
    <name>A0A370PUV8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_289498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="141" mass="16321" checksum="6EE726898FAF62BB" modified="2018-11-07" version="1">MAELCSAFEDTLQDNIKLEKHRFELLAIYRHDGDLNPHKTNNFSGPPRPELEEAWDRLMKNADIKVSHAELGEFAGDDSVIKLSDGSGYYVTVSAFHGLHCVKRLHMYIYAEHYYAGLSEFELFMLRRHTGMLRHHENNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV33</accession>
    <name>A0A370PV33_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_309586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="514" mass="54755" checksum="02D99C3D00E5C480" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV58</accession>
    <name>A0A370PV58_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_309602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV58"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016795753" evidence="4">
        <location>
            <begin position="24"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="227"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="6">
        <location>
            <begin position="777"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="887" mass="98649" checksum="464A16E3F1E7C942" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV80</accession>
    <name>A0A370PV80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_317249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="512" mass="56495" checksum="F3F4BD08D3F9EBAD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV82</accession>
    <name>A0A370PV82_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_97060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="2">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6314" evidence="2">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="225" mass="24652" checksum="FF6D6FADEFBA324C" modified="2018-11-07" version="1">MTTITPTLNLTHLFTSLPQKQWTLLRVLKSANPHDINGNLHGTASFTPLDTTTAQPQSPPQRQLLYTETGTLPAYIGHNLQWKKSYIWRLSAPSTSTSAVKDDLSVWFVKVGDERVADYLFHGMEFHTDTSDASTGGEGEGEEDDEYVSAPVPPAAGGETVVVTARGNHLCINDMYRTAYAFRVLKGDGGGDGIGEVVSWASRHVVKGPKKDQDIVNYYTLRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVB2</accession>
    <name>A0A370PVB2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_332771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVB2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="30911" checksum="4AED0049C9492666" modified="2018-11-07" version="1">MVNWKQPESADRLFAALIVAHPSLKLDYHAIATYFGQEATYDAIQNRLRRCHALAEQLRQEAFERGITDVPSAKGRKSTTGSIASPAPRTPRVGRNGIQKPVTSSSSRRRPAPRTPANLITPTRSGAGSSKAGQSIMDAISLEDDMLADEETDVKSTVKAESRSAQVSTTADPASDGSDVEILEVPPSPPAHTASKVEDIHDSISVFPSYSSYSFNSGNGLNVKREREQSHFLDFDDTPVKDTNPTPASNAFSGSRSNNDTSLGLSGIGGFTHGSSSSYDMDDPWGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVD0</accession>
    <name>A0A370PVD0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVD0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="77" mass="8674" checksum="69AFC6D70C998C2D" modified="2018-11-07" version="1">MNNGRCRCVLFCAAFVFRPETPQSHSGSVLPGRFFQTSHSHQWDDSEQTMNGWAGCYSVLDMAFITRAATKVLTFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVQ5</accession>
    <name>A0A370PVQ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_99874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="123" mass="13518" checksum="38F259BFC7AA0DAF" modified="2018-11-07" version="1">MNSSHAFSSRSATFSCAVTGYIRSTYQADQQVLTDPWFAHLFFCQPIFIGDDAVLFRDPDPERRPITPRYFNPAFSGLRVSASRVSNQASSVLLLILLGGPVQCAVGIAIIIFSIARYTVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW63</accession>
    <name>A0A370PW63_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_102752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="72" mass="8208" checksum="C38DAC71A1580BB8" modified="2018-11-07" version="1">MCHTSLRFPLATTTLGACHSYLTVTLHTYNFLTHPPLARLVPPESLFGFYLTFGSRWSFAFFLSSSPPRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWQ7</accession>
    <name>A0A370PWQ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_310116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWQ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="205" mass="23869" checksum="0A84243D8FCC3EA3" modified="2018-11-07" version="1">MLQQSLPCLVIRAAPNLHILRLGLWDQFYNLSSNLFTGLAQQVRFTCFSELHLRWVEPSQPSFQLFLRTAAPTLQILTLIAVSFDDPIPVGMDPSPELREAMSTLWRRFLNTLRDTIPTIGFFRMRWIAHRQHRFSRMDPLESAIGLRNLYSHDIYVYKINTKLRPGYLLDHRLPRHRSMLTLCDSVFEPQYYLPAARGRVANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX29</accession>
    <name>A0A370PX29_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_244733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX29"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="535" mass="60397" checksum="4597643A5547F7B1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX84</accession>
    <name>A0A370PX84_ASPPH</name>
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        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_281614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
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            <begin position="57"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="59423" checksum="A7169130A871377E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYH2</accession>
    <name>A0A370PYH2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_245493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31736" checksum="5EC7B32D7C894DF3" modified="2018-11-07" version="1">MSTQLAASAASIARISLHDPNNFNIQQSQTLHRLTLLQHWTIPTGSKVLELGCGQGDCTTVLASAVGEQGSVVAVDPADLDYGSPYTLAQAQSHISQSPLGSRITWIQQSPLTYLTSLPPSSSLTFDATILAHSLWYFSSPSLILSTFRAVRQHSKRLLLAEWALVATHPSAQPHVLAALAQAALECRKPGDSSDSNVRTVLGPKRLTELAVEAGWKVEREEYVEAGEGMLDGSWEVAACLDGEFEEEVRRVVGDERERAVVLAARDACETSLKGVEGGRKGVRSMDVWVASFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYV7</accession>
    <name>A0A370PYV7_ASPPH</name>
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        <submittedName>
            <fullName evidence="3">G-patch DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_323743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RBM17"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="531" mass="57610" checksum="EE855076B99F6597" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYY5</accession>
    <name>A0A370PYY5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_243681</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="12"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="889"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="643"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="755"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="929" mass="103800" checksum="8EC79699EC4326F1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD0</accession>
    <name>A0A370PZD0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_288038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZD0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57431" checksum="74FC508A773D1043" modified="2018-11-07" version="1">MLCDECISCLLPATGLAEDHFTAFQFCLQHFVRVHAREFPFLHSSSWRTSWELSGKALAMAAIGGCRIPSYGGHSRLYFDLAVHQVKSFTASLDGAEYQDAPGTATWNDAYYRRLLTSFETYILLIRYSVWSEFADLREWGIKSLADHANTVMPRLARVMSDNSHNSTSWLLWLLLEESKRALWCFYCLAVKCRHFLHYSISTFEVVVGNIHLPCPDSLFEAPDEQTWTGLNNSNAPQHLIGLTVPSQIAFYYLMSQEPMPQLTPNKVGTYTSHILLCNLLDTYETGRTSSWNFTSLDAYLDSDISCFRLRTELIRALDYWKWLFWRDPHELWHSRHPDHQINSMMLCVYLEAQMWSSSKPHLLSASRRRAGAQLAFDLLSLISRTGFLEVGAKSPFYVEPVVYFCTRSLGQAMLAWYDSLGDVERTIGRATDDADCMLYDKILECLNRLPGTLDGFSLPRVQEMPLLEYGALLQAMINWQMRVFDRETFIIEFESTGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF0</accession>
    <name>A0A370PZF0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_271867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20302">
        <property type="entry name" value="cupin_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="180" mass="20234" checksum="7604F7E33A3C72E5" modified="2018-11-07" version="1">MTSPSANDRPKATAIPYQGDPLPNVPEDLVVPDIVGLDFEERLWVPQAPDVWFRPILFNVTQGYFVNLLRVRRSGILSRHRHTGPVHATVLRGKWHYLEHPWWATEGSHAFEPPGDIHTLEVPDGVEEMVTLFHVTGAYIYVDPVGNALGVEDVFSKLASARAHYEKVGLGADYVDQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q012</accession>
    <name>A0A370Q012_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_331547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q012"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="461"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="74024" checksum="72CC2CD487871EFD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0M1</accession>
    <name>A0A370Q0M1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_8621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="115" mass="12850" checksum="98566B49BD023C8B" modified="2018-11-07" version="1">MVMLKRFKTNDHRIQHIHGHTIAPKCSDVPDVRHTIPQLRACSTIVSRTTYLTCHSAIQPGASAVVSVQPQATSAVIGYPFLGFVRTQCRTLSLLLVRFRVAYVHMLVCHIGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0W3</accession>
    <name>A0A370Q0W3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_322991</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0W3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK48086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="447" mass="49929" checksum="B9806E4FA0D7FD4F" modified="2018-11-07" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVVDVVRREAEACDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAYSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGRVSMKEVEDQMRNIQSKNQTYFVEWIPNNIQTALCSIPPRGLKMSSTFIGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASISEGEEEYVEEEPLEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q114</accession>
    <name>A0A370Q114_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_10958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q114"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="132" mass="14864" checksum="63FE97FDD48DFD46" modified="2018-11-07" version="1">MLFDVQLRVLLRLCIFHMSMIEGRSDGMAVNVSFCLGRRITTAHVCSYHSSVSSIFNVLEHRESFYLHFPTFCDTPLLLHFGYSSLLLLASTFHFLHMEPHPSCPVAAIVILSMLSLCSLYADQTRLHTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q151</accession>
    <name>A0A370Q151_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q151"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="398" mass="45313" checksum="1835FB81C4A5FF19" modified="2018-11-07" version="1">MDKNSPQEASSPTVVYSNSDDHVSEDESSPQTENVQDLKAQVAFLRDQLEILHGKASLEIELQMKMLTAGAKGWSDFDFEVLGNMIRQVMYRIKHWCQQHVRQGLPDTAELSGLEKQAIIRSLEGYWVQDVEWDTLRKSLPYPLSVCMSEVLAQTILTKNIVEKFFVNPFWYLEGEEFNQQDKVTGSVSCAQNLQHLYQRFLETNGIRATIWKKETVRLSNSVMLTQAPNLELGRQTKEYRTKAVALFASTLLSDPFFQRLLESVDCEEAKKRENSLIRICQFADDTAITLGSNQGHCLYKTLASVGTTFDPRSNEATLHELYNVGGNADDARLAGRRILGITQPVVILKLRTLRSQENVLNKAELLVEYGDYTEEDLVRDRPKPAENPDEEVEKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q184</accession>
    <name>A0A370Q184_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_244383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q184"/>
    <dbReference type="SMR" id="A0A370Q184"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="33470" checksum="6520B4406F86A8B4" modified="2018-11-07" version="1">MSNLEHTKKVYTLNTGDKIPAVGLGTWQSKPNEVREAVKNALLKGYRHIDTALAYGNEAEVGQGIKDSGVPREEIWVTTKLDNPWHHRVAEGIDSSLKDLGLDYVDLYLVHWPSSTDPNDLKKHLPDWDFIKTWQEMQKLPATGKVRNIGVSNFGIKNLEKLLNDPSCKIVPAVNQIELHPNNPSPKLVAYNTSKGIHSTGYSCLGSTNSPLYKDETLLKLAEKKGKTPQQVLLLWGVQKGWSVIPKSVSKSRIDANFELDGWELTAEEIEQLDNLKDRFKVCGDDWLPVKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1A1</accession>
    <name>A0A370Q1A1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_12626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1A1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="392" mass="44525" checksum="680F051070DDEF5F" modified="2018-11-07" version="1">MEDSSFEYPSDILYTQEPLSGYKFGGYHPVRIGDTFKDNRYTIHHKLAWGGFSTVWLAHDNLRHRWVSLKIKTADTSYSSQELQNLQQLEKIAAPDDLSSKYILHLLDAFIQPGPNGIHQCLVFELIGPTIDRIITDYRELSDSLDPQTILRLSRQLLKAIELVHNAGVGQIDISGRNIVFSGRNLSYASEKIIFAVFGSPEHEPVTHLDGTPLHKGFPAALFGPVSWEDWLEEFAEELRIFDLGEGFAQEEKSRILAQPGPSRAPELIFTGRSDHRTDLWHTGCMLFFFVFGTYPFDSDVEDMVVVEQMIDLLGELPQEWQATWDRMREEAGDMMDFQGDEVFTLEDRFDKEVAEPELAPLVPIIRALLEFRPSERITAPQALGLLGAQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1K2</accession>
    <name>A0A370Q1K2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_13784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1K2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="196" mass="21334" checksum="88E9180C494EA6B8" modified="2018-11-07" version="1">MENNNLLESLLDLEEEFYQEGYDLGAADGAQAGYTEGSVFAVEKGFEKFLELGRLYGKALVWSQRLADSQLSGKAESDGQNNGALESDHKQEELSLLDPAICKEMSSFSSSSRLAKNIEILLELVDPASLPMVNTEEAVNDVDERMKGAAVKAKLIQRALGEREDNSDIHPDAKDLPVSGDGTGSIEDISSLNIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3T1</accession>
    <name>A0A370P3T1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_116704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3T1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="946" mass="105895" checksum="C0ACC1BCF942E7E0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P419</accession>
    <name>A0A370P419_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_243140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P419"/>
    <dbReference type="SMR" id="A0A370P419"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="8">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="197" mass="21585" checksum="1DD15A1AEA5AA830" modified="2018-11-07" version="1">MAEVAQPVPAESQAKHVVYCGVCTLPPEYCEFGGTAKKCEEWLKDAHPDMYQSLYSEEALNSNLATLSVSARERAAKDAAKKEAKAAAAEARDAERKAASKVQIKRVERNKRKHVTVITGLDIYGLENKKIAKDLGKKFATGSSMTRSAGGTEEITVQGDVSDDVKEWLLEVYGKEIPEANIELIEDKKKKKATEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4C6</accession>
    <name>A0A370P4C6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_225701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4C6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="543" mass="60660" checksum="4F6DF270BD2A8BCF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4J8</accession>
    <name>A0A370P4J8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_280263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4J8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="37844" checksum="AB21DEB76585950C" modified="2018-11-07" version="1">MSGARHWEQDKEATVYIGNLDERVTDSLVWELMLQAGRIVNVHLPKDRVTQSHQGYGFVEFISEEDAEYASRIMNGIRLYGKPIRVNKASADKQKSVEIGAELFVGNLDPMVTEQVLYDTFSRFGNLVNIPKIARDDNNLSKGYGFVSFADFESSDAAITNMNGQYLMNKQVSVQYAYKKDGKGERHGDEAERMLAAQARKHNVRPPTQPLPPQFSNPGTPMVPAAMANGDSSRPMSTNPPDLNMGRGMAPPNVPFQNVPPPQASRPVPPTSLANPPPGLPARPPPSQAGYGGPQSFLPPGFNGAGQQPPFPQAAPPPGFAPPGFGSPAGTPGPPPPLPPGFQQPGYARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P509</accession>
    <name>A0A370P509_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PalH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_259358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P509"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="768" mass="84993" checksum="54A73AB79D320E43" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5K3</accession>
    <name>A0A370P5K3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_271005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5K3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016697093" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="14601" checksum="9471F927B2960891" modified="2018-11-07" version="1">MKFTVAAVAAFAAGALAQNVQIASPKAGQTVQAGQKVIVQIERPTPPTNVEEMAIAIGLQSCASATCYPASEVLGQVLYNGAFDPEYHEWYLPQYQNFTVTIPEGTASGKAVLGVAHASLIGASFEPYLQTLSQNITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5W7</accession>
    <name>A0A370P5W7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal N-lysine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_258994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5W7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="415" mass="47628" checksum="B11E65EE3D06874E" modified="2018-11-07" version="1">MKPTWWPGEQHELFTEWAKTQGIVINGVSPARFPGRGLGMIATRKIEKDSILVKVPHSAMLTPSKLPSTFTSRFPPDTPTHTLYAAYLTNASPSHLKPWRNTWPTMEDFTSSMPILWSSTSPLTPNSKTSKIQDLLPPSISNTWSTITPGKRKHKSDTRHQNLLKAQETRLRKAWDIVVRVFPETDKELFTYHWVIVNTRSFFYLLPGAEMPEDRNDAMALVPFADYFNHSDVACNVKFDGEEYVFRAAKEYNEGEEIYMSYGPHSNDFLFTEYGFYLDTNASETLYLDEIILQDLNASKQEELEFHQYYGNYQLTSDGVCYRTEVAAGLTYMPLRLWQDYVLGYSTEGVDEKMSAAVIRGWIGVYIKEADVAIARLEDLYIAQTEDQGVVRMLLKRWRQIRGLCEEAVDRVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P688</accession>
    <name>A0A370P688_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_279647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P688"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="546" mass="58083" checksum="D67C7ABE6D3B3066" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6W9</accession>
    <name>A0A370P6W9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_309078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6W9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="478" mass="52265" checksum="355D0981AA3E45EC" modified="2018-11-07" version="1">MDTVDIHEGQLKDASSHEIEDVDATEVVSFTPEEEKALVKKIDMTLLPTVWVMYLLSYLDRTNIGNAKISGMEVDLNLTSNEYSIALVVFFVGYVVFEVPSKYDFSTHDLALGRSRPSIFLSSIMILWGALTCVMAVVKDFSHLVVLRVIIGCIESGFAPGVLLVLSSWYKQTEQSKRFGVFISAAVLSGAFGGLIAAGIVDGLEGVHGIRGWRWLFIIEGVITVGCALISLFVLPDFPATTRRLSDRERRIAVARLARENVTATTEDTEHLSSLGACRVACQDFRTWAFVVGYMVIVGSSTLTYFYPTLVKGLFGDASTEKVNFLTVPIYGVAFVATGITSYCGDKFPTWRGLIIAGWLAFSLICSVIVCAVYNFTARYVLLVLMAAGLWSTNGGTLAYASSAFAGMHPQARGVALAMVNALGNLAQIYGSYLFPDKDSPKYIMGFSVISAMLAVGVVVFLVLHIWFRRRLRSGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P729</accession>
    <name>A0A370P729_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_223811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P729"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="265" mass="30199" checksum="37F5A1442B177DAB" modified="2018-11-07" version="1">MRISQDQPEITLYRGFPGTGIYTWSPFVTKLEARLRLAGLSYRTESGSIRAAPRGKVPYVTVSDTDESGRNQARTMSDSGLIIQDFVKEGVLPDLNGDLTVQEKVLDSGVRALLEDKLYFLQGYEKWIDNYYSMRAHILASLPYPVQVIVGHLIYRKQYQVLHGQGTLRYSDAERTTFKKQIWEEINALLADSRLNSDRKGVFWVLGGQRPTEADVTLFGFIVGALICTACPETQRIVRGLPVVVEYAHRIHDRYFPDYELWAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P790</accession>
    <name>A0A370P790_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_308751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P790"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="142"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="31495" checksum="0FA3EFE2123E262C" modified="2018-11-07" version="1">MQPAAFHPSRHYIWPVLIDRSHRKSTKTSDKQIQTSIPSGPPTRFLRAKTAKTMQPITLYSHPIGPNPWKVAIILSALHIPYEMIMIDFTEVKKEPYVSLCPNGRLPTIVDANKNITLWESGAIVNYLIETYDQSHQLSYDTFPERHQLQQWLHFQVSGQGPYYGQLGWFRRQPEQVPQAIERYTAEIRRVMSVLDQVLTDREWLVGDKCTYADLSFVPWQDLVPLVVGDQRVVQELTEQFPHVEAWMQRMRARPEVQKVLKEKSEAMASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7M1</accession>
    <name>A0A370P7M1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_308050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="40925" checksum="EBF148BCC6813F7E" modified="2018-11-07" version="1">MEVPSPNWKVQDLLYGKHDKWTRITLACKGKCFQIEISPENFVQSPSSFQRYSRYIDLMYDDENAAEAAEDDLYDWVLAPFLPIFDQVEPSLTTGKTATLRDYLSPEIYYFQLYFVDERMEPRYDYEVRRTLREPGVDIGDFALHPNWGKFTPEMVEQCLSDGEYGYSKHPRKVCVDGKLCFLKESHTKRGLLRELDIYRKMENQGLRDDPQVHIPRLVGVVYGSHDSCCIIGILLSLVDCEKLTLSCALHDEVTFAQQKKWEEQITTTVDLLHRADIIWGDVKTDNVLIDKNEDAWVIDFGGGYTEGWVAKEHMETMKGDAEGLSRIMERIYSNDGSQDGGQGSHEEEVANVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7X8</accession>
    <name>A0A370P7X8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_279191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7X8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="204" mass="22278" checksum="175A8041A4942A9C" modified="2018-11-07" version="1">MTSTSNPPTHFSISTARLNITYFDPTSPSHSAFLAHLWNTPDFIATNGKTSITDSHAAQTFIQTRIIPQYTCKGFGLLLVNLRPTSNSPHQNTIPIGTISLMQGDPPNGYSAPDVGFAILPEHQGRGYATEAAKAVIEYVQREWNVQGVFGFCAPGNMRSRRVLEKSGLEFRGVRKLRVFGGKESAVFALVGMEEDLGVYGIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8D7</accession>
    <name>A0A370P8D7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_297384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8D7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF3">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="13929" checksum="F2ED5AA770A3F35B" modified="2018-11-07" version="1">MSTLQPSVNRALVLHPGGTFTHSERRIPTIESDRDVLVRVVATGLCGSDHGKLGRYEVAQPVILAHESSGVIVATGGNVHGLKFNDRVALKPRNPCNVCPYCRSGRYNLYTFDSLESHCIMEKLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8S2</accession>
    <name>A0A370P8S2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_239726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8S2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="264"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="39680" checksum="FD85E311118A8605" modified="2018-11-07" version="1">MYTPRIGDRLSSLDTPSMIVDLDLMESNIQKLFSALLPTGLNIRPHLKTTKCAALAKKLVAAGAKGCCVAKVSEAEAITAAGFDDILITCEIIGAPKVQRLVELARKHPGRLRTVVDSEVGATAIDEALEQAGITTPLAVLIDLDVGLHRTGVADVQAALALARHLAGLKHLKLIGVQGYEGHVQHIHSWEERRQECLASMKILTETAETLRKEGFQIDVVTGGGTGTVEFCASVPGVTELQPGSFIFMDTDYRNAIGRGFSNSLTILSTVVSRQGERQVTIDAGLKSLTTDSGLAECKDSRYAHQNLGDEHGALSWTEGTPDLKVGDRVEMVPSHIDPTINLHDFYYAHRGGVIEEIWSVDARGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9M5</accession>
    <name>A0A370P9M5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate 1-monooxygenase sala</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_239485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9M5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="166"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="436" mass="48220" checksum="85731726115ED2F7" modified="2018-11-07" version="1">MSPSKKDFHVAIIGGGIAGVTLAIALHHRNIPVTIYEQAHEFGEVGAGVSFSPNAVQAMKYCHEGIHNAFEKVCTRNLWPTKQKVWFDYLDGYNHKESPQNGRQNIEFTISNSLGQNGVHRAHFLDELIKLVPKEISRFNKRLEDIHERISDGKLIMKFADGSEDVADLVIGCDGIKSQVRQIIVGADHPSAKPSYTHKYAYRGLVPMDKAVEAIGEELASNSCMHMGPGGHMLTFPVNGGKTLNIVAFHTTTDEWAEYPRLTRQGTRDEVLRDFAGYGPNVTNLLKLTDPQLSVWAIFDLGDHPVPTFYKGRVGISGDAAHATSPHHGAGAGFCIEDTAVLATLLEDERVQTHKDLQAVLAAFDENRRERSQWLVQSSRFIGDCYEWRADGVGSDFKKIEEAINYRNGVIANVDVGKMCEEAKGVLGRKIEKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA06</accession>
    <name>A0A370PA06_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_256054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA06"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="380"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="551"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="702" mass="77581" checksum="AA919ABA85CBE849" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA6</accession>
    <name>A0A370PAA6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_278581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="237" mass="25624" checksum="8E337EC07DBB471C" modified="2018-11-07" version="1">MSLKAISSKDAASLDKDLMEIGGWSLDQLMELAGLSVSQAVYRVHPPSSGKDVLVICGPGNNGGDGLVAARHLAHYGYKPSVYYPKQGKNELYQRLKTQLENLSVPFISDLPVAIKSADFLVDAIFGFSFGGPLREPFPTIISQIETASIPVLSVDAPSSWDIESGPPKEGPGSKFMPEALISLTAPKPCVKYYKGRHFLGGRFLTKSIADKYKLDLPEYPGIEQIVEVGVNAEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAG4</accession>
    <name>A0A370PAG4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_220811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAG4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="496"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="703" mass="78536" checksum="DA6F4F48D419BCD4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS3</accession>
    <name>A0A370PBS3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBS3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="533" mass="60438" checksum="7E6A5910AF109F76" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC66</accession>
    <name>A0A370PC66_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UMTA methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_338093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC66"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="328" mass="37420" checksum="08BF092BFF432289" modified="2018-11-07" version="1">MPQPDSEEHIQVDTSDEDSLIDEQSIIESNISITSSVRDYCYENGRRYHAYRYGQYPMPNDEEEQDRLTLMHHAFKLLLGGDLYRAPIGDPQRILDIGTGTGIWALEMAEDFPNAEIVGTDLSPIQPKWAPPNCSFLVDDAESDWAYIGNEPFDYIHARSLGGSIADWGQLLRQAYENVKPGGWVEIQESETWIHSDDGTCKDAVMVRELQQKLEESSTKFGRRMNIAPEVKGYMQRAGFVNVVDDIYKCPVGTWPKSPRLKEIGRVGKLILYDSVEPYTLALWTRVLGYSYEEAQAFVKKVHAELASSTYHIYIFFHYVYGQRPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCI3</accession>
    <name>A0A370PCI3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_255337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885469" evidence="7">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="507" mass="56877" checksum="D9A518ADA7028EDB" modified="2018-11-07" version="1">MSILIALAFACLILLPLYLLINHQIPSLPLPPGPKGKPIIGNLSDLPPPDTPEWQHWLEHKKRYGPITSVTILNQPIIILHDAQIAIELLEKRSLKYSSRPQPVFVGEMIGWKDTLGMQPYNARFRAYRKAMHQVLGTKALVSRFDTLQELEARRLLRRMLEDPGEWVQHLKTEAGAIILKIGYGYDINPHGRDKLVDLADDSMETVSAVLNQMWLVDLVPVLKYLPSWLPFSAQRKSQFWRTQLLTTIETPYRMVREQMASGIAPPSYLSNLLREEDTKEEKTLTAEEEFTAKWTAGSLYIAGADTTVSALRTFILSMALNPAIQGKAQAELDTVLGPHTLPKLSDRDKLPYVNAIVKESLRWYPVAPMGIPHLCVEGDVYDGYRIPKGAIVMGNIWAITHDPNIYPHPEKFDPERFLGENPQPDPSGWVFGFGRRVCPGRVLADASVFVTVGMVLSAMRISLEKGEGEREEVRFTPGVVSHPVLAGVKVEARSGRHEGVIREVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCW8</accession>
    <name>A0A370PCW8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_254998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCW8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="622"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="859"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="965" mass="108102" checksum="05085AA83BAF2ED8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD16</accession>
    <name>A0A370PD16_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_48198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD16"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="8">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="7">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="168" mass="19122" checksum="E0B88088F507AD16" modified="2018-11-07" version="1">MADTPAPHSGPMLTFISGDGVHIECERDVAERSLLIKNMLEDLGGANEEIPIPNVNEAVLKKVIEWCRHHKNDPPSTGEEDDSRGKTTDIDEWDQKFTQVDQEMLFEIILAANYLDIKGLLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDN9</accession>
    <name>A0A370PDN9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_303898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDN9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF38">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="333" mass="37701" checksum="662409B29C2F5395" modified="2018-11-07" version="1">MLSNKQAIGTLSLGQHPSHTLDQKIRVASQHGFTAVEVVYSDLKRYSDALGVPMLDAAGKIKNLCDDLSIEILSLAAFENFEGNRTSLDERMATAKHWIDIARKLHATYLQVPSNYSHDASTDKNIIVSDLQKLADLASAEEPVVSVAYEPLSWGTYCSTWDTALEIVEAVDRKNFGLCMDTFHEVTKLWASPFETSGKYPTADRDLTASLERFLKQCPLEKIFYVQLSDGELFDPPFSEAHPWYLEGEAPQFTWSKHARPFPFETELGGYMPVLEIVKAWVVDKGYTGWISMEVFDRRMRNAEFNPQDAGKRARKSWETLQDRLRPPTPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDU1</accession>
    <name>A0A370PDU1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_295543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40735" checksum="54CD55DBBDE22CC8" modified="2018-11-07" version="1">MSTTSLCESEVFTSARLVASDCKLPPNDRYGEYYPTDPKNLKLESNFGPMLPEKIGYLQPTSKDTPIEVMRERLIRDGYLFVKQLLPRNQVLECRSNYFSYMAPSGLLKEGSDPVDGIFSDNDSRKFLPPGNLRRLFGLKDDYESEKYLELMIKAHEERFYLQLCESTELREFIHKLTEWKDITMLQRTMLRAFVPDSELTPVHFDQMYLRAGPPTSITAWVPIGDISLEGSGLMYLEKSVDIGRQTEEEFTRNAANLTDEERVSAFNKNMNDGGFLSRDTVAYGENAKRKWLITEYEAGDVIFHDPFLVHASCKNKDPERKIRLATDLRFVNANEPYDKRWMKVWRPLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE83</accession>
    <name>A0A370PE83_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_277781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="8713" checksum="E220B926F603DF77" modified="2018-11-07" version="1">MAQTPQQRKANERFAKQESAKRGKGKTVAKSKQTPRSPVSTVWVAILAFVVCGGIFLEILGIIPKLWSTMVASINRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEK0</accession>
    <name>A0A370PEK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine peptidase, family S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_253734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720988" evidence="6">
        <location>
            <begin position="23"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="562" mass="61683" checksum="F363248060FE51E5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEP0</accession>
    <name>A0A370PEP0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_254420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEP0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000020">
        <property type="entry name" value="Pre-mRNA splicing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="698"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="919" mass="101945" checksum="DC6AFB57E147C228" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEZ9</accession>
    <name>A0A370PEZ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_328147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEZ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016687775" evidence="9">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="220"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="49452" checksum="B6DFBF73B4B5D809" modified="2018-11-07" version="1">MKWLNLLPIALGLANASIISFSPPTNPDIIYSLTIPNTTTLSTPGPIYIQITAPTSIQWVGLGQGAQMTGANMFLLYTSSSTKITLSPRSGLGHFEPQYTSNTQITMLPGTGISTINSTTAALTNSSSPSSDNTRTTMTANFRCDNCLTWQDGTGTMNPKDPNFPFIWAYREGVPINSAAMDADISIHDDMGGIQVDLTRAGMPPQPNTSTTEDDQINPFTNYNPATDSVPVQAPSTPTSPLPNLTKMTHILITHATLMSLSFVLFYPLAALLMPLPISLPVSKFRLHMPLQIFTMLMTLAGFGCGIYLAYETGQLKTAHPILGIIVVGVLVLFQPAMGWLQHWGFLRTGGRTGWGVSHRWLGRGVIVVGVVNGGIGLHAARGMGMAPLGAVIGYAVVAGVVGVVYVVGVLVGWVVERRRKRVEGERADGEGVGEVQRGASVEGRDVRENDGEKGGSVEERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE9</accession>
    <name>A0A370PFE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_253102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="32"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="38529" checksum="79616801D3C842CD" modified="2018-11-07" version="1">MSTNINNIPLSYATCSLGPPSIPLEDKLSSLSAASFTGIELAFPDLLAYANTHNAGTTQILPHDYTSLVHAATEVRSLCETHNLQIMMLQPFANFEGWPRNSPEREDAFTRAKGWSQIMEALGTEILQIGSTDTPAEKLSLGDSKNKENVVDDLRELADILAPKGQRIAYENWCWSTHAPGWKDVWEIVRDVGRENVGLCLDTFQTAGGEWGDPTTADGVVGGGGDEVRKRYESSLEELARTVPAEKIFLLQVSDAYKPPSPFEDAVVDGARPRARWSHSFRPMPYHGGYLPIEEVGRAVLRTGFRGWFSMEIFDGGVNGDEEIEDVGKFAREAMGSMRRFLERCADGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFG0</accession>
    <name>A0A370PFG0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_319783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="801" mass="89789" checksum="975E54824F135206" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFK0</accession>
    <name>A0A370PFK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="125" mass="13055" checksum="6D61AAE7F6CEC1D3" modified="2018-11-07" version="1">MSQNRLPGSTRGGASAQPTPANNSGGGSGWGDEGYPKGGGLGTANQTSSDEVSPDILTTPALQGISQQKQAAEQKFMSRWDEGHDEREGTCATEDHSFMGTKPGGSDALPGWNVLKDKLGFLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFT6</accession>
    <name>A0A370PFT6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_294710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFT6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="95" mass="10884" checksum="5E369E260B9B8F71" modified="2018-11-07" version="1">MLEELNILIATVVNEEAYRVEQQSEAETQNEIMELLRKMLQDKDDPDPVVWILLELATGGICPNALASPREFWTGFVCCRGYKPTIFQVSAWRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG10</accession>
    <name>A0A370PG10_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_267891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25680" checksum="80C6CD8DEE57DF18" modified="2018-11-07" version="1">MNVFDEEPSNITLSTPKASTTGTTIAIILEELRLPYTFHLLPHSSSTTTLTDIHRTGHGPTLHSLPSITTYLLTRYDGDHHHHHHLSYPPHSPEHVAVQESLSKLADRMGITHHHLHHQDSEPDNKHEHKHHHNKQHLPAIKETEVVGNNNNTAKETATATVPFARRLLSLYLHLEEYLSRQRRGGGRIWLMGHSTVADIAHFPYVAAASQYGFDLERFPELTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGX1</accession>
    <name>A0A370PGX1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_294283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016787408" description="Fungal calcium binding protein domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8504" checksum="44DB3EED5BC09CB8" modified="2018-11-07" version="1">MKTWVFFLAAFAAVANATSVNLNHEREASINTPIEGLEKRCRGSRALPALIAAVALAVSSPGAALVLKLKPRLSEELDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGY1</accession>
    <name>A0A370PGY1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_284277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1481"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1500" mass="167501" checksum="4D35645D7C8F48C6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH73</accession>
    <name>A0A370PH73_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_301977</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="507"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="590"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK41547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134918" checksum="38E5122E91A791E8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHH5</accession>
    <name>A0A370PHH5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_319729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHH5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35957" checksum="9F29B24BD11661C3" modified="2018-11-07" version="1">MSSTADHLSAASTKAIAPRSKSQTVQVEFGGQKVDVPKGGYYDRYRMNPNLDEVAQDPNIGHDIAFLRKIPKKLVDSRVGQVYAPNFYYRTSSVQLVILAPLDQLKSKLPAPLEPLTALPGYGLVALTFYSYLVCDNDPYNEVSIAIIIRQPGNASYSPTQLLSSIWNRTFYGYVLALPVDTEIARVRGIYGYQLPKWLANINLKMDNHDIKADITATDGTPDLTLHVPLPALRTIPSESQIGTNNAVNKIDGKWYQVAVQTNPLLATQCLFPTNVKLARNEGPLSQLLNELGVSTIVRMDVIKDAQMVLNMPTPLKVFNRVGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHR5</accession>
    <name>A0A370PHR5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_301864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHR5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="7" id="KW-1207">Sterol metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="386" mass="41893" checksum="7FF2962949A51DB9" modified="2018-11-07" version="1">MAPPSEKTKAQFSQVLTGIEHITRHNQDPFKVKIENFIGYTHVPVGLAGPLHIRTPTGPDKEIWAPMATTEAAVVASCCRGCKAANASGGIEVHMGEEGMTRCPVFQFQNPRDALRFARALPTLQASFKEVAESTSKHARLQSLTPHTIGRSVHLLFNYTCGDASGQNMVTIATDRVCAWVSKNLEKEYKIVDTFVEGMLSSDKKPSWRNVTVVRGVETVAWTALSESACQRILGCSSAKLYDLIQITQDAAIRNGEHGSNMDSANILAAIFIATGQDAACVADASWAHLTPEYDQMSKTLTLSLYFPSMPVGVIGGGTSYATQQEGLRIMQCSEPGGKRRLAGYIAAFALALEISTASAVVTKTFARSHEQLARWEASERPRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHW0</accession>
    <name>A0A370PHW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rxt3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="847" mass="90919" checksum="598A8E959FC0B120" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHX1</accession>
    <name>A0A370PHX1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_319383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHX1"/>
    <dbReference type="SMR" id="A0A370PHX1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479146" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="520" mass="57793" checksum="FBAFE6877B8BED6B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHY5</accession>
    <name>A0A370PHY5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_252026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="291"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="609" mass="68533" checksum="4811B4677F64B8EE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI72</accession>
    <name>A0A370PI72_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_216535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI72"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="956" mass="105772" checksum="BC7E41EBD5D4B6B2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ14</accession>
    <name>A0A370PJ14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_14441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="46328" checksum="9DB007288ABA66FE" modified="2018-11-07" version="1">MDPISMDIAISAGLQVGIQALKILNRWLHEEEIAKTWYGKSNYKIFTRRRYWLIFYQPWKFGGREIQRVFRIKKDAWHKVIQNCLTDCYSWHQRMKENYEGECCWLLLYQSLPDETQTNCLEKPQRSLSSLGIITSLPAARVDSWGLVVMALANGAKIEATNPPDGACNFSRLDAQYFVLTIWQNNVAGPITAHIEPKEHPSECRSLTSPEWNNLLWYGHSFGEHDHIFGWPLLSKKPPEPPNDLVSDIRNEELSRLVIDNMRVKRLRDQLREAIYDCHDEWDNLKSKVQSDIDLRDQITDIQQNLRRLKLVLVDEEQPDETPYLQEQRPEDTLHYAEEQLKLVQNKVDERRVNLVIAKPSPKSRLSWIQPIYVFEVTFSRWKTITPDLRSTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ31</accession>
    <name>A0A370PJ31_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_327463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05118">
        <property type="entry name" value="STKc_CMGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="437" mass="49470" checksum="F7F15F6310AD009F" modified="2018-11-07" version="1">MSISPPPTPPSRAVTDDEWRFETITLPCEWVEDYHPGGYHPVVLGDVFNNGQYKIIRKLGEGSYSTVWLACDLRDGGYVALKILVSQLPESTAELHILRHITETAPTEAARHVTRLLGEFEHHGPNGVHKRLVFEPMGPSVNSMVEELPQFKPRMFGMKVRYPLWMAKSILKQSLDALTFLHRNGIAHGDFQPGNILFTLKDLCSTPEDVLRQEEDVEAELISPPVQRLDGKEDKWAPRYLCVAQPLSPFTNYTEGFNVKLSDMGGAYFFTNPPTKPVTPLGLRAPELILTGVVNNTLDVWSFGCLVFELITGERLFCVPPSEYEDDDHLLSLTERLGALPDELFKHWKTSSLYFTPDRKLFNCQIGGVDPGEEPLMVEQISMEEQFDSAEPDIDEKEADEVKTLIRWILQYDPAKRPSPEEILSHPWFRNIGAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ55</accession>
    <name>A0A370PJ55_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_300290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="59484" checksum="96EF68DDEC05BC67" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJX6</accession>
    <name>A0A370PJX6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_301667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68951" checksum="90E9392BA006B062" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKM9</accession>
    <name>A0A370PKM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF94">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="41903" checksum="129754BC1FD9D5EC" modified="2018-11-07" version="1">MSSDSTPDPRLEKPRVAVASRLNFFTSQLNTSIEASSIEDLCSVYRPFELLLETGAHSGLWWLDITAPSEEDIEALARFFNLHPLTTEDIKTRETREKIELFGQYYFLSLRPPRRLETDTGVRIVSHNLYAVVFRGGVLSFSFDPSLHTSHVRQRIKEHSSHLLLTSDWICYALIDDIVDGFAPFISRVENGVVTVEDSVSITRPDDMGLALQRIFKLRKEVMNIRQPLHDKIDVIRSFARHCDISDTSSSQVALYLSDICDHVVTMIANLEQAEQMLSRLQSKYLTQVHFDSGRMRNGIASALSKLTVLASILVPMQFITGLFGMNVRVPGKTHDGDNSLTWWFSILGFILGLTVIFAWVAKRIGLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKV9</accession>
    <name>A0A370PKV9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_318969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKV9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="31587" checksum="5FC5B26B3BD5EA49" modified="2018-11-07" version="1">MSDLDRAIAQLRACRLIPEAQVRELCYKARELLIEEGNVVCVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALIRLIDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGGDIVKRFNYRNDLSLIARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDTSNGGTAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLC2</accession>
    <name>A0A370PLC2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_276080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLC2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="16354" checksum="9CC42ECE03E3E83F" modified="2018-11-07" version="1">MSDGEETQSNPVVAADEVEVSADAGAGGQMSVLDALKGVLRISLIHDGLARGLREAAKALDRRQAHMCVLNEGCEEEAYKKLVVALCSEHKIPLIKVPDGKMLGEWVGLCQLDREGNARKVVNCSCVVVKDWGEESQERSVLLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLE7</accession>
    <name>A0A370PLE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_319069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000014">
        <property type="entry name" value="Translation initiation factor eIF-2B alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="37495" checksum="D6C115B56C0E08FF" modified="2018-11-07" version="1">MAAPTSGSSAAAKPFDIVATYNDLLRSDPDLTMPIAAIEALVLLLTNSPSSTISETLDLLEKSTAHLKQSIPNPIGLSAGTDLFQRYLITTLQRPGQLGPAGDFNAIRAHLLSNGRLFIRRAKESRDKIAAFGRGFVRDGSTVLTNGGSRVVASLLQKAADEKGGPSAVRFKVIYVLSSAKGTGAHPDEPEGMETVRALRAKGVPVATIPESAVAYSMGKADTVIVGAEGVVENGGIVSRMGTYQIGLLAKAMGKPFYVVAESHKFVRIYPLSQYDLPIEQRVIDFKTEEDVADEAKQQQALSTDTVDAKAVNTADSADVVDFTPPHLISALITDSGVLTPSAVSEELIKIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLM4</accession>
    <name>A0A370PLM4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_234077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="522"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="642" mass="69563" checksum="633A5E7402C068A3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLR3</accession>
    <name>A0A370PLR3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLR3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="52" mass="5720" checksum="A3C49D5962CBB9FA" modified="2018-11-07" version="1">MYPFPPCLFRCTACLASCRSCASLTNHCGVAALHDTVRPSCAFEIIFIIIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLU5</accession>
    <name>A0A370PLU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase TilA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_282987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">ATCC 13157</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laccase TilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
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    </dbReference>
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        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK43168.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66237" checksum="63484540A5D4E23F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM13</accession>
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        <recommendedName>
            <fullName evidence="7">SRm160/300 splicing coactivator</fullName>
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    </protein>
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        <name evidence="5" type="ORF">M752DRAFT_154425</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Baker S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">ATCC 13157</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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        <location>
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            <end position="1449"/>
        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="RDK43230.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM58</accession>
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        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM58"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="44878" checksum="E0B13E3BBCA0C7AD" modified="2018-11-07" version="1">MSNQQVGTVFDRVIQEVCDGSQVDFEESGVDQQTLLDLRKSWQKKLSSLGVAHFPWDPPPPQPAPPQTQNILPPTATVPSNAPRPGPPPQPQHHVPPPPLQQPIPQSAPATAPPLQAPTPVGAGPNAMGQQQPHIKTEPGVNGQPGMIPMNNMMMPNSSNPQSAQERAANMLRQRYGAAAANSVSQLQAQSQAQAAMAMPGQQRPQPMQHVPNGQAPQIKQEPGYPPVSQPPVGNTQTDGAGDDALSAWKAEVARRREAAERQGGEGDRLLREHLRQRMLQLEGGGLMLPLDEHDYSSKTLTRGLVATQAEPAEVSEVAGSSLHPPKVLGAQFDGPGGDDERDEDDEDAINSDLDDPDDLVAEDHDAEDAVGQVMLCTYDKVQRVKNKWKCTLKDGILTTGGKEYVFHKGQGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPB6</accession>
    <name>A0A370PPB6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_325910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="426"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122079" checksum="689E5292B81C16D5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPD2</accession>
    <name>A0A370PPD2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="576" mass="63185" checksum="545465260179DF98" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPI6</accession>
    <name>A0A370PPI6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_232514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPI6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="8">
        <location>
            <begin position="332"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71924" checksum="631804B5E50A19F5" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPM8</accession>
    <name>A0A370PPM8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_318564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPM8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="159"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="58688" checksum="1E60AD72D2D8643D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ10</accession>
    <name>A0A370PQ10_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_231175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="611" mass="69638" checksum="2BEE6A8BCCAACCF2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ58</accession>
    <name>A0A370PQ58_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_313123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ58"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="84"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="26428" checksum="C0F2616F67E7F80E" modified="2018-11-07" version="1">MTKKPFFLIASSLTLIIIILTTLTTANSFPLRKRLPRPFVSAPHLRHDLHLQDTTNNYLADLKEWLSQQPSTNKMGSQSSSHENPIISDVLPKNRLINIYASLTRQFDSVESRFNDPSSNVTVLAPRNSAIQNLPRKPWENPEDYERFGQAGAYEGDEGQDRATKNLERFVKAHVVVGSPWGEGDEGVTLAGEKVRWNRGEGGKIYIQPGNVEVDSIAEKVSNGELWILNGVVNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQH7</accession>
    <name>A0A370PQH7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_334358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="266"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39755" checksum="631CB281252B5672" modified="2018-11-07" version="1">MTDLTPTFSELLRSKSPSSKLSTGYMTTEIADEFLKEAYRINNHITSLLSYLHTIRPSYLSLTTKPTTKQQHQHQQPEILDDTARDTITTTTSTLLSNLSTSITTLSAAENLRQETVSRSITQRFGKGLLAKWAGGATLSSGNNDNNEGKEEEQVVEEEKEKVLKGVRESVLFYLRIKLGGVVNEQRDMVEKRIERVRERERSVLYKSSGGKGGWGSVEGGKWRGDVAGGGTSGSVMMDESEVKEIEKQLTPQQLQLFEEENDSMVKYFEDVVGKVQNAEKSLLEISSLQQTLVSHLSTQEEYISQLVTDASNTEANIGQGNKELKRATERRSTAQAVFWGTVGLCTWLVVWDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRJ6</accession>
    <name>A0A370PRJ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_333730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="484" mass="55092" checksum="EFECB22F411F3F0A" modified="2018-11-07" version="1">MLYLVLALSLPGYLIALTCYNLFFHPLRSFPGPPLAKVSKLWSRIGNRTGRKSDRIHEAHLKYGPVVRIGPNELSFAKPAAARAIYTSDAMVKEETFYRAKTIFHENHLFSTRDVQAHRQRRKLFARGYSQAAMLEFEPHISNKIDMVLKQWKARVVDGPIDVYPWLHWLAFDVVYHLMFDDDPGQVTSGRSHEVMEYLQAWKPTYIYKEFFPQLDRWGVYVPGYVGDYFRKVQAWKNYSVNLIQRSRERGTKTPFLRAALNGDEDAFLGRPLTNSELAEECMGGMFAGSGTTANTFAFLLWACLRKPAVVARLKAELREAFPDPSIVPDHRTCSALPYLQAVISEAFRRYPAAIAILPRTAVRHTTIAGVPISKGTVVGAQNRTIHFDEKAFPDAQDFRPERWLEKENEALRKEALAPFSLGPRKCVGLNLAQMELNKLTAAFFRRFDGEVDGSMGEEDMRMYDTFTASPAGGRLLVRLRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRM1</accession>
    <name>A0A370PRM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl coenzyme A transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_230266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="696" mass="77238" checksum="1B214050AB5FCCD0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRR4</accession>
    <name>A0A370PRR4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_274166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000002">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18168" checksum="B39BD6FB7AFFE5FD" modified="2018-11-07" version="1">MGHSHGLRAGTRYAFSRNFKENGQIRLSTYLKTYRVGDIVDIKVNGAVQKGMPYKVYNGKTGVVYNVTKSSVGVLLYKVVRNRYLEKRINVRIEHVKHSRSREDFIKRVKENAQKKRQAKEQGVHLHLKRQPAMPREAHLVEGTAAETITPIPYDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS06</accession>
    <name>A0A370PS06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAE2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_317876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="658"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="808" mass="90100" checksum="14730C287E34EF35" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSQ3</accession>
    <name>A0A370PSQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_312933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="30578" checksum="9E9E77A42CFBCC62" modified="2018-11-07" version="1">MPSPSKRIILEKSRTVRRRYQRSNKRFQFTASQIARIEREQEREKRAQQLRDKEKKRVANKKKKAEKEARDREERRRLGRMGLPDPNAPAPPSSQPLLFKFIKKRDGEEGGSNSGGGDTEVDEGGDTEVNEDLLENLEAVVDAAEADLDLDLDTEDEGEEGEGEDHRDEATSCDQGENEGEQQVQAKEEDEFSDCCSIFYDEDVIKETGNTTAPDQGAPQDKPQPENHAQPENHSAADSFQDDTALLLEEFGHEFDIDEEFEQALVALDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSV5</accession>
    <name>A0A370PSV5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_334110</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSV5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="35"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="202"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="315"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="12">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="585" mass="65377" checksum="FCFC8C6A666A2731" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSY6</accession>
    <name>A0A370PSY6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_210977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSY6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="37599" checksum="3DEBB869A17FAA0C" modified="2018-11-07" version="1">MAPVPATLLRALSIPDPAKASLSTAGLGSGFTNTGAIRATVPRSDGSGEEERRYFVKTSPNGEAAEEMFRGEYESLNAIATSVPGFCPRALAWGPLEESAGTSFFLATEFLELGGAGRRGRGDTLAQRLGKLHSTPAPPDPATGRRRFGFPVPTFCGDTKQPNRFCDSWADFYANERLLTILESSETRNGRDAGLRDLVERTARMVVPALLRDGHLGYDRDGNGQGITPVVVHGDLWSGNADRGQIVGSGRKDDEEVGDVVYDPSACYAHSEYELGIMRMFGGFGSAFFAAYHKIVPKTEPVEEYEDRVRLYELYHHLNHHAIFGAGYRSGAVSIMQKLLRKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT23</accession>
    <name>A0A370PT23_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_281700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="499" mass="56586" checksum="FFB4864E06E83E9E" modified="2018-11-07" version="1">MDYYKALIVLIVYLCLRTIYRLALHPLRGIPGPKLAASTSLYEFYYDAIKGGKYIWEVERMHRQYGPIVRISPREVHIKDPYFYDEIYTSSSIRKRDKDSKLVASFCAPTASFSTVDHNLHRSRRAVISHLFTRKAVVSHEFLIQDNVGKLASRLESIHKKGSVFSLKIAAAALISDVLAQYMYGTSTHYLDDPTFRSESVASATELASKIHILRHIPVIATIFQLLPLALLRPFRLLSDFCDFRLWLRKQSQDALQGKGGSTVRRGPVFDALLRANVPAEEKTLQRLEDESFTLFSAGSETVSQALSVIFFHLLKNAEFIKPLRKELKQVMPMPTDLATWSELEKLPFLTAVITEALRLSGTSGRLPRVSPTEPLIYGKYIIPAGTPVGQSNYFAHRDPAMYPNPNAFDPYRWIHAEDENTNPKPFYAPFSKGSRQCIGINLAYATLYLTVATLIRRFDMEISDSTEDELRTARDFLIPFPEKGQAIVKARVKNVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTC1</accession>
    <name>A0A370PTC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_273703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="162"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="470" mass="51607" checksum="C1D12CC5CE5BC093" modified="2018-11-07" version="1">MPPPKLGYGLNLPSKSTSRPNPPVPKRKKPIFGDDSDDDGPQPTTNTNKGPNSGGGAIEITTIGGLDDLTPSNNQEEEEKTEERPAKRKLLAPGASSGAPKPPNMKPLNKSSIFADASDDDNEEANTPTYGLNPSTSKPNPKSKDIDTTKPYTNLSALHSSRKHAAEASELDPTIYSYDAVYDSLHAKPGKDKKASDSESGSTVPKYMTSLLRSAEIRKRDQMRARDRLLAKEREAEGDEFADKEKFVTAAYKAQQEELRRVQAEEEAREKEEEERRKKNGGSGMVDFYRDMLSRGEERHEAVVKAAEEAAKKVKEGGAVVEEEEGEKEKSEAQVAEELNAKGAHIAVNDEGQVVDKRQLLSAGLNVAPKPKQTQREKDAAAAAASRAAVQASRFGAQRQAERGGQRARQTEMIASQLEERARQEEEAEAARQKEIAERSRSRKTEGDVMSAKERYLARKREREAAAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTI3</accession>
    <name>A0A370PTI3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ser/Thr protein phosphatase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_311588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016877520" description="Ser/Thr protein phosphatase family protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74074" checksum="2B621595CB4BC1B6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTQ2</accession>
    <name>A0A370PTQ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTQ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="442"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="534"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="688"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="985" mass="112247" checksum="CE2B05D4327E31DF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTS0</accession>
    <name>A0A370PTS0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_324470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="192" mass="21295" checksum="8D16787BF2B63848" modified="2018-11-07" version="1">MHFLGWVPRARSEHGGRESPEEYAEPGPAHEVIRGKYSKQKARIVVGCSVQTGWVPSTIFTDKYRFWTGWNPWNIKFKSRTPAWDPNSGASTNGRVSFGFEWLNLWAPKAPIKGSDTWGPSTIKNISSNTALLGYAQINITGATSLEGWLNDRELGQKKVAMLEAIIGSVVVDGLSRTGSYQLFKFSDPSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTS3</accession>
    <name>A0A370PTS3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTS3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="410" mass="45504" checksum="588E5DF51A417D27" modified="2018-11-07" version="1">MVEKGEANYPEALFARLEDSLEKAIEDGVFPGVVVAATNKTGSLRYVKAFGRSACNDTGVPLSPQSVMAFASMTKLMTCIAALQLVERGTISLDDDVGPLLPDLAQSKILTGWDKEGMPLLRERQNPITLRHLLTHTAGTGYDMTNSDLARFSACQGRHINSGETVKERFGYPLTYEPGTSFEYGCGIDWVGQLVEKLSGQDLESYMQENIWGPLGIQGITFWPAAKPDIRNNQIRMAIREPNSERVTDFTGRFLTEGVTECFGGQGAYGDMESYLEILFSLLVDDEKLLSRQTTEKLFSPQLSHSSKHSLNEYIRNHPPNAFIGIFDTESEYDWGLGGILTTQDTPSGRQKGTLIWSGKPNLFWFIDRLSGLCGVFGVQVLPPGDEKIGKMIQIFENTLYSARETRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU21</accession>
    <name>A0A370PU21_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ethanolamine utilization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_324538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU21"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13236" checksum="F4B90F75632D1471" modified="2018-11-07" version="1">MAIAFKHHPRSQQTYEPPLIANENAFLGDVDSSDSYNPEKPISAGFYRLEKGTPLVYEYTFDEMKIILEGKFEISDETGQKVEAFPGDVFHFPKGSKVTFTTPSYGLAFFTGQRAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUB7</accession>
    <name>A0A370PUB7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUB7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="231" mass="26036" checksum="5C4DEFFD45079EDD" modified="2018-11-07" version="1">MSQSHALSDDQVAGELRKMTAFIRQEALEKAREIQLKADEEFAIEKSKLVRQETAAIDTQYEKKFKQASMSQQITRSTLANRTRLRVLSSRQELLDDLFQKARDQISGIAAKDASKYEAVLKGLVLEGLYALNEDKVSIRARKQDTDAVKKAIEEAEKEFKETVGKETSAELDEEEPLPEGSAGGVIIIGGQGKIEINNTFEERLRLLEIDALPAVRETLFGKNTNRRFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUP4</accession>
    <name>A0A370PUP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_317701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="387" mass="41268" checksum="153ED301D3F45F33" modified="2018-11-07" version="1">MPTTPLRTALIGLSSSAITSWAADAHLPALQSTAGRSHYHITALCNSSVAAAESAIRTYQLDPATVKAYGNPDELAADPAVDLVICNTRVDKHFETVLASIRAGKSVYIEWPIASSLTHVDELLAVAGASGASVAVGLQGRFAPAVLKVKEVLRSGQLGRLLSTEVRGFGGTLDREFLPPGLKYFSQKEVGGNPIVIGFGHMIDYVQSVVGDVVAGTDEARTQIQRPRIRIRDPQTQKIVEEVDSDVPDLLSVHGSLPESPYTVPGASLVAYFARGQPFPGDPSLSWTLNCEAGAIRLSAPAGISLQADAYQNPATISIHQHATDTVEAVEWAWSEEQLEVPVKARSVQRTLIDFAQGNREGYVSLEDAAGRARQLARWLDASGVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUZ8</accession>
    <name>A0A370PUZ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017026646" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="26613" checksum="458C7E8F7DADF015" modified="2018-11-07" version="1">MKLFGWISAAFLASTVLSIETTPAPSIDTIPFYPPRNADSGRRAFEVLQLLRKRGDNCPSGYDSCTNLGYSDICCADGSRCTRDAADNVACCPTGASCTGTLSETGNAGGGATSSFRFPQTATATQTTDGTSVTLTGSTIAGAYPFVNIPTSFANARVCTSYYSLCQSEYTGCLSQLGGGYAVTVAAEGGGVTRAGGGASAAISTCSSLSMEACHGLSIGYCGSYSTDVYENRGTMPSRSSSLEDLFFGMIIGLAGMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVH0</accession>
    <name>A0A370PVH0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_332803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33075" checksum="30C26604FDB6D37B" modified="2018-11-07" version="1">MLNRLRNRSLYDLLHVDPPRDRAHVYETSWLLPPLPYAILRGTISLYIFTSIFFIWGWSGTHGDRAEIGESFSYFTWLTYWGLGFYMLFASIHTACYALKGHSVLFDRWPRALRALHGLFYATVTTYPFLVTVVFWGILYSGPWYTVTFSGWQNISQHGLNSLYALSEIILPTTAPHPFLSFAVLVFILLLYVSLAYLTYHTEGFYTYSFLDPGPHGEKSAHVTGYCFAILAIILVFFLFSWCAIWLRRRLTGGKVKRSVYDRDYAGAEVGGDIEEEVGVEEMREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVZ1</accession>
    <name>A0A370PVZ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_209352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000021">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="79"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="277"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="434" mass="47179" checksum="AFE17CDBC71F7749" modified="2018-11-07" version="1">MTGLSSENGSTEPDERAALLGDIARSNSGLRPRQQKLHWSHWPRRVAHLTWSTLVRDYVNVLLIFVPLGIISGALHWDSTVIFTLNFLAIIPLASLLSFATEELAATMGQALGGLMNATFGNAVELIVSIIALKDNQIRVVQASMLGSILSNILLVLGCCFFVGGLKYSQQSFNSTVASTMSSLMTVSSASLIIPATLYASLSGSKDKEQRRDNILILSHGTAIILLVLYVMYLYFQLKSHAELFEAANDELNDTENQGGEVEEAEEEEHLLSPWAATVALIVITVLVAICADYLVGSIDSIVTKTGMSRTFIGLVLIPIVGNAAEHVTAVVVAWKGKMDLAIGVAIGSSLQIALFVTPFLVILGWIMNVDMTLHFHIFETMAFFISGLVVTFLIQDGKSNYLEGGLCLGMYLILAIAFYIYPDDVNEDALFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW23</accession>
    <name>A0A370PW23_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_324098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="136"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="336" mass="37467" checksum="1D698229FB437828" modified="2018-11-07" version="1">MVASAWLSRQPLRCTLAFPHLPGTESSTTTFENERELPKMANQGYDVVVDVDAEGDLGHTDLQEDLEFHRSNFENDQRNAKAQQDSAPFLGGGSSRGRDRSPGGTPSKLNWWSIHYYSQFFDVDTNEVLRRCVAALYPRSNFLDVLEGNPDLYGPFWIATTVVVILFLTGTISQWLSNNDDEHFEYDFTLLSGAAGLVYGYTGIIPIALWGALKWFGSSSADLVESWALYGYSNLVWIAVALVSWSPLTALNWALVGVGFGWTVFFLLRNLYPVLSATDAKASKILLILVIVLHAGFALAIKILFFAHGSPVSKKNKDHDDDDDHDDDKRRMFGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWE5</accession>
    <name>A0A370PWE5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_290017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWE5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF87">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="336"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="409" mass="45307" checksum="A4DC87450F61A9B5" modified="2018-11-07" version="1">MMKRKSQLSSFTLVTAAILPFVHLVMGGTSLPQKPQMGWNSWNAFKATVNYTIVQEVISLFDTLGLKEAGYEYVLLDDGWASYNRTSDGYLQANATSFPQGIKALAEEVHGKGLKLGLYGDSGHYTCAWRPGSWGYEERDAQTFAGWGVDYLKYDNCGGFQSMTEAPQIRFGAMKNALALSGRDIFYSVCGWGYQFPWHWGGDIGHSYRMSGDITTSFSNETECQCKTAYCLNTGYAGCSVLTIINKMKEISQYQTPGHWLDMDMLEVGNANFTLNQQQTHFAFWAALKSPLIIGADLSKLSNDSLAVLTNKAIISINQDALGEPVTYREAHSKEGLFQVWAGKIEDGYVVLLLNEKSYPQTVSLSFASLGLGSPQKVIELWSGQTLQDFSKFNGVLGSYQTLVFKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXF1</accession>
    <name>A0A370PXF1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_64793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXF1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="483" mass="52420" checksum="84BC25F786571A0C" modified="2018-11-07" version="1">MNAYLLNRALGSISPSTFHVAQTTRLVQQLEPAPGIRFSARRDILLGERQAGNEYPHEDAGLVFDDEVFAHKAGVNVLAIDHYEGRFMVSGGADPSINLWDLETRGSDLKHVHQPVASVNRASHEDAHTRAITSVSIYPFDPTPSTILTTSYDGTLKLSALGPGAITPVHTFNLDCTPYTHSLSSNPGSPLLIAVGTSEKPVRLLDLRSGLSTHGLPGHESSVLSVSWAPHQPHILASASADNRVILFDIRRGGHNSAIAALDMDDAVGLVRPGSIPASYQSRPAFSPHARAHNGAVTGVRWTSSGSHLVTAGQDSRIRVWDAGTGANTLVHFGQRVRNSVTSHLAERAPLIIPRGMVTPGQETLLWPNFNERDDRGEIFMFELREGAFVKLLRVPGLMTGRQQFQGRSSALSAARINALAWRGNGSSGEGIEMYSAHGDGTIRTWASREPEGEPDDEAEEAERADRKRKRDILDELYRGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY85</accession>
    <name>A0A370PY85_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_70470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="386"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="536" mass="53786" checksum="5BF29D1662A37283" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYA4</accession>
    <name>A0A370PYA4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_323585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000093">
        <property type="entry name" value="Calcium homeostasis protein Regucalcin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="35027" checksum="F90B37A28D103518" modified="2018-11-07" version="1">MSGFQYQKWTVSEPYVDVPGTLLEGPFHDKTKNEFRFVDIWEQKLYVLDLAKGPDSLKIMDTSVSIGVTANIANAGDSRENQIVVAAKHGFALVDRTTGALSYIQKVWDDPAKEHRMRFNDGAVDSHGRFWAGAMNDSKVQNPVNEGVIFRLDPDMKLHRMVEQVTIPNGIGWNPADDTMYLTDSPTGKIYAFDFDAETGNISNRRVFFDIGEPKEPDGFAIDEEGCIWSAIYGGGKVIRISPEGKIIGEITFPTRNITCPAFVGTELFITTAKDDTNDDQFPESVRYGGRLYRVDVGIKGKPKNEFRLEGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYA9</accession>
    <name>A0A370PYA9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_317077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="333"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1395" mass="156466" checksum="190447FA362006EB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ92</accession>
    <name>A0A370PZ92_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_331355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ92"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="165" mass="18279" checksum="9109A71956B08428" modified="2018-11-07" version="1">MFKTGSAGVLLSEEQEDQALLPQHWPYGVGNEFVASKPNHPFVIKVALSVHEHRWGFVPAYVTAFVSAGAVLVSRVLGVWLSAVGGRVGIVPRSMFEGTEKAFFMRFVEERPRGDEVAVAEWFFGNWIGWCAAGVALGVMGMVVFGVRREPRVRRDRVFTLVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ95</accession>
    <name>A0A370PZ95_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_226640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ95"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="24590" checksum="031D94D523F90778" modified="2018-11-07" version="1">MHSPLDPTLQFDSIEDTIAAFKNGEFIIVLDSQDRENEGDLIIAADSITPAQMAFLVRHTSGLICAPVTPEIATRLALPQMVTENADPKGTAYTVSVDAADPSITTGISAQDRALACRILGSPTSTAADLRRPGHVIPLQARPGGVRERTGHTEAAVEFCRLAGKTQAGVIAELVEDGEVVPGVPEIGGNNGMMRRDGCLRFGKKWGIKVCTIEDLVEYVERVEGAGAVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF2</accession>
    <name>A0A370PZF2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_299469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="62237" checksum="93AE9B32076DFA22" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZS0</accession>
    <name>A0A370PZS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_206445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000678">
        <property type="entry name" value="Putative UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000592">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000006">
        <property type="entry name" value="UV-damaged DNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="425"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="784"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124499" checksum="F50D4A1B62003A81" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZZ3</accession>
    <name>A0A370PZZ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="4 9">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_331524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="4 9"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZZ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000369">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="41853" checksum="B1A4F5CCE5EBFCF7" modified="2018-11-07" version="1">MSASHIPNLNTLRRGGGRGRFRSRGGGQTGDAGHGSHGAKDRVVQGTDNDASVSRLSAVNLGYLDDVYAPALTPPGMETRRLPIINRGTYVRTTAIDRLVTRFLNAHPSHPKKQIISLGAGTDTRIFRLLSSPTYDASNLVYHEIDFPVNTSAKIKLIRAAPLLQRVLSSSSSDTVEISPTNDALHSPSYHLHPLDLRNLPTSPALPGLDPTLPTLLLSECCLIYLTPSEASLVVRHFTETIFPATTPVGLVLYEPIRPDDAFGRTMVANLATRGIQLQTLQEYASLGAQRRRLRELGLDGGQAAADVDFIWERWVSEREKERVAGLEMLDEMEEWQLLARHYCVAWGWRDVPGGVFEGWRDVPGGVFEGWREMEGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q030</accession>
    <name>A0A370Q030_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_288270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q030"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000014">
        <property type="entry name" value="SET domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="498" mass="56444" checksum="A9C943F43F9DBA04" modified="2018-11-07" version="1">MKHEYYPIETLPSWIKLNGVSVNGIAFRKLQADDGTDKGSAIVGTEVKSTGNAEGSEVEPEVLLRVPTDLVLSFDFVEEYSKSDRQLREVLEAVGDFGRTARGAILIFLLVQLTHSSPDYASERHQIGLSSPWTEYMKYMPPAISLPTFYSEEELELLRGSSLRLAVHAKIASLEKEFEHLRRSTEGLDWCEKYWWDEDTGKLTFNDWKYVDALYRSRMVDLPRHGHAMVPCIDMANHASEGTVKALYDEDADGNAVLQLREGRSLRADEEVTISYGDEKSASELIFSYGFLDEHTTDAKQIFLDLDIPDDDPLKIAKKAFCKDTPGVKILATSPDSSETVAATTWDSPIIWWACVNEEDGLDFNVLQTNDGGRELKATWNGQEVSDPGCLRDLLAADPRWDIYQLRAAVLILERLETQFFVLRQTDMMISEIRENEDMRAVFDPYVFQTILRLRELESKLMEQAIEDLVNQRETLMSSPAVSAYLTQQSGDIEEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0E6</accession>
    <name>A0A370Q0E6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_331666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0E6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="46974" checksum="1C6930FE20499F07" modified="2018-11-07" version="1">MSDSVDRVFVHALNTVKRIPRTGTARPPASERLKLYGLYKQSMEGDVEGVMDRPVGNTADVFMECEKWDAWHAQRGLSRTEAKRRYISTLIETMHNYASQTAEARELVAELEFVWDQIKSNPSSSSMSSSQEPGSPVASAAVSMRDHARLQPQSSNRLTRPEYEQLLANTARGRGSERLRVLSPVSQAESGFRRQMEEEPAEEEEEEEEEEVYAEAQDNLFENEEGEDDDEEGHMEEEEYNNNHDRHESHDYHQQGYNFPSHQEEYDHDHHHHDTLSRRRPPPPPDDSKRWRRTVEQALTTMTAEIAAVREQLEARALAHRRRTGLWAWLKWLVWVAARQIMVDLALLGMLLIWMRLRGDRRLEEKLKVGWAEVKTRLVLLMVFRRVRRVVSTSPESSSSGDKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0T2</accession>
    <name>A0A370Q0T2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Supernatant protein factor, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_272251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0T2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016886192" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="23471" checksum="C13E0085CB2B9B0B" modified="2018-11-07" version="1">MRFSATTLLITALAWFSTVTAHNIQLRAHSRECFHESLHKDDKMTVSFQVGDREFGGSGNLEIDFWVEDPLGNRQYYKHAISSEDYSFNAHADGKYVYCFSNEGWASNSKEVSFNVHGIVYVPESELAQDPLEAEVRKLSEALAQVKDEQSYIVVRERVHRNTAESTNARVKWWSIFQLAVLIGEGIFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q121</accession>
    <name>A0A370Q121_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_272074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q121"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="53" mass="6294" checksum="2424315EA2ED2F0C" modified="2018-11-07" version="1">MPGGCGRQVAESFFYPWETLSQHEMMRLKEYILDFDVATGRNHKRVSELRRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q156</accession>
    <name>A0A370Q156_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_272350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q156"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="88" mass="9906" checksum="1E1669A12C0331B7" modified="2018-11-07" version="1">MSNPTATQDTKAEPTQQPQQQKPPVLEEDDEFEDFPVEDWPQEETEQGSAANGASAHLWEESWDDDDAAEDFSKQLKEELKKVGASNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1P9</accession>
    <name>A0A370Q1P9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1P9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="175" mass="19268" checksum="A39A35D646D4D793" modified="2018-11-07" version="1">MSRTRQIASEPASSSQLELTEEHTETSSAVPVPATLRLRGADEPAANRLELNEGNSRRIRWSEDVIDNEGMGKKSSKVCCIYHKSRPIGDSSSESESSDSSTSNSDTDSDDEAACHRRTGHRPPTAQGENYASSGQRLSSNSEERTCRSSHRARKTKRKPSPNAYEKMPKTTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3H2</accession>
    <name>A0A370P3H2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_125259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3H2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="170" mass="19162" checksum="1705658133ACACAA" modified="2018-11-07" version="1">MADHLQASVSSLGSSLQLLDSSISTLDSGISDFPRLCKVLQTTRHFELLPEPTLREAQQSLLDEITPSIAHLLSLASNHVEKLSRREQGLRAKCELQEGRMYSNESRQPSRMRSAFGDRLQSAGASGKAAKAAELKRLMQKKERLQYAVERLELQSTQRERQLRKSMAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3W3</accession>
    <name>A0A370P3W3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_113918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3W3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="54467" checksum="98A512B13E6F9A4C" modified="2018-11-07" version="1">MNRKKDQDSVQTTEAAQSAKQTQVQISSDAAEDVAPDQSRRKTSKLSVLLMIVFSGLAIGSDGFNASIIGNLELIMEVIYPKALTTAVASRLSNAFMVGMIIGMLSFGYLSDRLGRKTGAVLTTVILVLGIALSAGASGTNRDGMFWMLIIARGIAGVGAGGEYPVAGAGAAEATDEDLGVRNKRGFIFAMIADLSASLGFAFGALVPLLLLLCFHQQVHHYEAVWRISLALGVIPPLSIFWFRYRMAVSSAYRKSAMQKQAVPYWLALKRYWRPLLGICGSWFIYNYISYPFGLFSSTIVGRVNPTSSLALTMAWGTLINCFYIPGAFIGGFLSDRIGRRRTMALGYFLQAALGFILGGALGPIEKSLPLFIVLYGIFLTLGEVGPGSTIVVTASESFPTAIRGHAVGFAAAWSKAGAAIGTAVFKPILASWGDDEFRGTQAVFLIGSGFAVLGGLLAWFVFQDVDHALDNEDQAWKDYLAANGHGDVQWGIASNSTHELESKAVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P445</accession>
    <name>A0A370P445_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_225998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P445"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="308" mass="36151" checksum="955085608404ECA0" modified="2018-11-07" version="1">MLCYSICFFRSLWPRGAREGFDSARELAQYLINHYNEVNEGFGRPLSLYDKKEGADPRNWTLDYNPINSMFQPRMDAYWNTKITSPIMSGDRALEYMGYFFETMDKLFKVESDNMDTLQIYFMPAEGMWTAQELKSVVRAIIHFKDVIEEFVDPDLHNANREYDATKEMNPEVKEALINGLELATSFDHLHQFLSSSSGLENFRNWKFWQWPGAKCNTLVFVREYIKLYSDEDIKNWYIFVETFICAAMNSHGPNIYKFDANMEGLQQFLLRYNEDVDVQWLCAFTSPPSDMVLSSQALTKNKKKGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4B0</accession>
    <name>A0A370P4B0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_113051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2060" mass="233475" checksum="B4E4526D3DA248B0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4C7</accession>
    <name>A0A370P4C7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_243206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4C7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="632" mass="71281" checksum="4A24F2FECED5AD54" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4P5</accession>
    <name>A0A370P4P5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Teneurin-like YD-shell domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_310521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050708">
        <property type="entry name" value="T6SS_VgrG/RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305:SF15">
        <property type="entry name" value="PROTEIN RHSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1515"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1653" mass="180564" checksum="00B29D6194DF7522" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4Q9</accession>
    <name>A0A370P4Q9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_280188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4Q9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="238"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="39187" checksum="D4DB0FAAF5FDA298" modified="2018-11-07" version="1">MMTLRRSARLTAASVSKNNSTTTTVPHLQPKTQTKRAASRTTNGVSKTRKPAAAAARGKKAQLNAILKLDQAPPLTDSPTSSSSSSSSSSSSSSSSSSSSSRSNNSRQSPNTTTTATTNNIWDPIPTPTVHTSSSRTTPPPLDRPVEPHHTNATLLTPHGSSLVAYPPGTDADASPSKTGRPRPTATTGTLLEKAAAHLIATDPRLESLIREQPCPLFTPEGLAEEIDPFRSLVSSIIGQQVSGAAAKSIKDKFVALFKTNNKDEDGTRPSFFPTPEEIIKMDISTLRTAGLSQRKAEYIHGLSEKFANGELSARMLLNASDEELVEKLTAVRGLGKWSVEMFACFALKRIDVFSTGDLGVQYVIICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5E2</accession>
    <name>A0A370P5E2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_280027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5E2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK37076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="87775" checksum="AF22AD91E2BC534A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5E4</accession>
    <name>A0A370P5E4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_225131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5E4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61125" checksum="314E9F6651C9EE74" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5G3</accession>
    <name>A0A370P5G3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_224888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5G3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="39769" checksum="6C65ED7A1C576DC6" modified="2018-11-07" version="1">MSTHKAAVIYARDKPLVVENVPRPVASTGDAIVRILAADIVPYMREVITNRRPYPLSIPMTPGNTAIARIHEVGPDCVTLTPGQLVFCDITIRARDNPAVTMLYGIHGAIHPAAQKLMDGVWRNGTYAEYTRFPLENLYPLDEEVLLGRLGYSITDLCLLTAYLVPFGGLAEVDVKPGEVVIVAPATGRFGGGAVGAALAMGATVIAAGRNRAALDKLEHIHGTQRLTTVQTTGDEASDTQSFQTAVGHPDGANVYLDLSPPTIKDSSLLVAGIRALGSFGRCVLMGGHLGNIQLPYGEIMFKGIRIQGRFMYDRPHVFRLIQMVRSGLLPLGEKGGVTHSEEFGLDEIERALDAAERLSGWGGQVVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P626</accession>
    <name>A0A370P626_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_330609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P626"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF6">
        <property type="entry name" value="LETM1 RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42589" checksum="1234BF7507F4C298" modified="2018-11-07" version="1">MPSALHPPRVLLHPPQFTTAIASRLVHQHPHHHNYTLLSVRPYASHSKSKSNSKSHTRPSSAAQPTTTTTTTTTPTTTTSTAILTSLNPPPSTRPASLALPPSPEDPNTPLPPSAKLKRYITIGRAYLTFYKTGLKNVYHNYRAAIPLRRTLNLSPYVPSSIPPSPTTKDAIPFYQTLQTHSLHRSHFQLLRRSAHDIRRMIPFSLILIICGELTPLAVLALGNAITPLTCRIPRQLEKEREKRARAKRDALVSPGTVTPPETGSQDEMSVLKRMVDRKWIEGAEAGEVLRACAALGLARSYERPAWLVGVVYRGRLRRYAEYLECDDELIRRGGGVAEMEGEEVRIAVEERGGVGVGVGGVREGWEAEREERRWLERWIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6F6</accession>
    <name>A0A370P6F6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_279707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6F6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="791" mass="88539" checksum="A2C1C4348AE22268" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6L1</accession>
    <name>A0A370P6L1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_308827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6L1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="36989" checksum="F3AC46EF51F8E326" modified="2018-11-07" version="1">MKQLDIIVANRFQIVNFISSGAYGDIYEATDLESKTKERVALKMERTKFPDSLTRESVFYAKLQKGKTTGMLKLHFPTDICDDYRVMGIDLLGPSLWDLKHFCGGKFSLKTVLLIVEQALFRLKSLHDQGIIHRDLKPDNFLMGRGRQGNIIYLVDMGLAQERVEAPGNPMDYEGHQALSFVGTNDYAPRAAHRLHYQTYRDDMESFGYVLIDLLKDVLPWGHMTTSVGGVTPQDRMGRMKEQISLDNLCKDLPEVFKHYFEHVRSLRYNQRPDYTKLRQMFLSEFKRQGFHHDFVFDWTQRRFDQAAEESYVSFSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Z0</accession>
    <name>A0A370P6Z0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-deoxyglucose-6-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_321633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Z0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="376"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="59351" checksum="6294123B6110F3CC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P769</accession>
    <name>A0A370P769_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_270538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P769"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="728" mass="81625" checksum="862591B5984CA75A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7H1</accession>
    <name>A0A370P7H1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_339089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7H1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
            <begin position="283"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="469" mass="52473" checksum="5D19F1B62B30B255" modified="2018-11-07" version="1">MLDSFPSITTTIQYGLISPQATLLSIILPILLCIILLLPYLNPTPPPPKGCRRLGLSPSQRSNLHDEYSPKYAHGVPSTATDPDTGLSAWRIKALFTYPIKSCGGVELEAADVIETGLKYDRLFCFAEFFPSPQPTTTNTSTSTNNQEENNGTWTARTLRDRDFRQLALLRPEIWIPDPSSPTYSSTNPETLSNGVLLVYYPLPPSRNPLVTLLRTLHILPSQSSFTIPLDPPPHSLTDFPLTPVKIWKDIPLAHNYSHLLPQSLKDLLTYDTTLPPHQRRQLSLFRATHIHRREIYRNAPRKEKIGFQPVTGFADAYPIHLLNMASVRDVAANCADEIPELSVRRFRANVIVQGPGKFVEDEWKRIVVGGSSGDADGVEIYTACRTIRCKLPNVDPDTGVRHPREPDRTLKRYRRIDAGDLTNACLGMQCVPAVREFTLRVNDPITVLETGEHCYIKMLAPGEKVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7J2</accession>
    <name>A0A370P7J2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_307990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7J2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="16"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="32857" checksum="BF72B1FB400C2ED3" modified="2018-11-07" version="1">MKAEAGRHKTGLTPVHLFSHGSPLMIYETTECSKYWRKCGDEARAHNVKGISSHWATLGDGIEVATNPAPQICPMGIVPSNDYKTYKMTSDLATAQQCIDLLQAEGFNVSGNPQYNWIVDVYTIIQKMFPEGNPPPVTVVSSNARYDPHYHLKIGKTLRQLRKENYLLIGTGGSVHNLYRNRWGSMVKYRDSLAQEIPPEEWALEFKQSLEDVMTKTSGLQLQRAVTRLMKHPQFRDAHGTDDHFVPAAFVAGAAGDAEDEGCHGVLGAETWELSNMANLQFTFGKWPKQPPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7S6</accession>
    <name>A0A370P7S6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_240562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7S6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052990">
        <property type="entry name" value="Sulfoquinovosidase_GH31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959:SF2">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016697095" evidence="3">
        <location>
            <begin position="22"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="282"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="633"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="744" mass="82944" checksum="9CFFE4BDBC31F19F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P897</accession>
    <name>A0A370P897_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIG-P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_321293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P897"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="194"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="358" mass="39741" checksum="EA4CA32F14C09B60" modified="2018-11-07" version="1">MTLLDNEEDENSRYLRNNSEPPSVITSIEPKQPFPPLPADDLATTTLSSQNDGYVEEDDHDPTSPSHADIDAEDDADFQSQYSLDDQAFSDASTDSEEQSPEDGLSMHHPFRQSTSSLHGPNAFAPPFYNRPPTPLPPSPSLTSLLRPPFSTTTSRPTTPDSSDVETPNDTEAAVAKSARRATTVPRASPKVPTYEYYGFVLYLASSLAFLIYILWSYLPSPFLHQLGIYYYPNRWWSLAFPSWLVMSIIYIYVALASYNTGYLTLPMNSMENIVDEVANVAVIDGKGRRRPGGAAKMRPGATSYQIMGPQNRKVNWKEIWSEGTDAVLDVPVGGVCEVLYGQERDDDELFEEASTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8M6</accession>
    <name>A0A370P8M6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_76141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8M6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="82" mass="9028" checksum="A40FB73F0C0AAC36" modified="2018-11-07" version="1">MTSSVPLATSSIYFKTSENGACRWLQLYANQPGVSRNPGPIQVSCKDLCCFRSSTSFYNVDIMIRWGNPSNDAENIGYVGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P927</accession>
    <name>A0A370P927_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_321199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P927"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017083888" evidence="6">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="500" mass="54648" checksum="78CC43F18339777F" modified="2018-11-07" version="1">MFRLKMEVLTAIAAWAFATVSQQIPRSSSWESDLQTLSGRLSNTSQIYYPGSSGFTNATTRWSVLDEPEVNVVVVPGTENDVAEIVKFANQKDVPFLTYNGVHGALISLGEMTHGIAIYMGQLSSVEVAADGKTATIGGGTMSKEVTDQLWAAGKQTVTGTCECVSLVGPALGGGHGWLQGHHGLVLDQFVSMNIVLANGTLTHIDANSDLWWAVKGAGHNFGIVTSLTMKIYDIEYSDWAIETLTFSGDKVAEVYQAANDYLVKNGTQAAGVINWSYWMNNADADPNNPVIIFYIIQEGVKTVNSVYTAPFRKIGPISVSPNNGTYKDLAAWTEVAVDSAPCQKMGMANPRYPIYLETYNVTAQQKAWDVYANATRGSSAFNNSIFMFEGYSVGGVHDVDSRSSAFAFRNENVLAAPMINYYPDGAELDRRGANLGQELRNILFAGTDHEDIRAYVNYAHGDETPQQLYGSEGWRQQRLRSLKAKYDPTGKFSYYAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P947</accession>
    <name>A0A370P947_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_239887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P947"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="707" mass="80272" checksum="137776B12FB43D66" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P994</accession>
    <name>A0A370P994_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_77591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P994"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="721" mass="81013" checksum="0231A80B71F8745F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA77</accession>
    <name>A0A370PA77_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1,6 mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_320892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="251"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="725" mass="80519" checksum="23D32A4DD030DAF0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA1</accession>
    <name>A0A370PAA1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial 37S ribosomal protein MRPS16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_269237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11651" checksum="6DA64E0A9F60644E" modified="2018-11-07" version="1">MVVRIRLSRFGNRHQPFYNIVVAQARSARDSKPLEVIGTFNPIPQRPTNLSEQEARTAKAYKEISLDRSRAKYWIGVGAQPSDSVWKLLSLAGIVKESKNVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAK2</accession>
    <name>A0A370PAK2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAK2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="157"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="581" mass="67173" checksum="5B0AB131DBE63E68" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAV3</accession>
    <name>A0A370PAV3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_329032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="265" mass="30612" checksum="3CA8B6BA5E76CFBF" modified="2018-11-07" version="1">MDEILARERADRRHKLARIEELIRQTPSQHVEPADLKAASICHLPLSLEEDSEHHPRFFNPYPEELPLPEKEDEEKLLEFPPDPNHILWDTRDMEIFFTNHFSNSWEYASDEYPHNPPPSGIYREIGDYKFGQLLESVGFNWYAVSVTEYPEGNYPHFKAMLESEAIGDNRLLRGEIMTITDIMAARLRTRSLRPHINAPLLVVSLMGPRHARVLEADFAADMLNIRASKLYDFSRKNTDSAQLITRYWLGGACGQTTMQAMKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB24</accession>
    <name>A0A370PB24_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8518" checksum="97721C05BE8CBAC1" modified="2018-11-07" version="1">MSTPQFWSTPLRYLRWASHERPAIFYSLIIGSMGPVALVGLPPLRRALGDVDPETIPMSYPIPSGPRTFPKGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBI5</accession>
    <name>A0A370PBI5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_50244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15771" checksum="FDE86396226872D4" modified="2018-11-07" version="1">MVSIKWCGGRLHVYNRSLTRGWNWSGLCQTFRLQSLNLQLVKLSRAIGISPASISSSFCSAAVELSNQGPVSLGPVPFCPSVFSFLSFSLFFSRAPHLHAVLFYSLRFLFFFPPSTTCFCAFFLFLHLHNPTSARLSPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS5</accession>
    <name>A0A370PBS5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_320607</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000254">
        <property type="entry name" value="Myosin I MyoA/Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054489">
        <property type="entry name" value="Myo1_CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22773">
        <property type="entry name" value="Myo1_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="23">
        <location>
            <begin position="323"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="24">
        <location>
            <begin position="1060"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="1361"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1229"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1413"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1292"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1348"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1426"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1437"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1507"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK39651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1539" mass="169324" checksum="6D15E0CF5AE2DF1E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBU2</accession>
    <name>A0A370PBU2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBU2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="256" mass="29221" checksum="7CBE0BC959E1DEAC" modified="2018-11-07" version="1">MLQQLPCTPSDAHALATLYLQCFDRPVDQRLWPNTPEIHAWWVASFTRKLTEGVDKYHILKVIDTEKDDELVGFLEWKLPAPIQQDPTVSDTEKEEHADGEDPETQELLATYPSHVGDLGLLKITLEHFKTNVGAIMGERRFYYLNMLGTKPEYRRRGVASQMIKWGTTRADEEGIETFVVSAPGARPVYLKHGFELAREGEDMGDFVPWYMVRKPKIEAKEAKKKEGGYVKWLLGVSAVLGVAAIVYQRVYRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBV4</accession>
    <name>A0A370PBV4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_338009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBV4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="13813" checksum="2A0B41A76DA5D2CA" modified="2018-11-07" version="1">MPYTGRCNCTSISITLPAQPERSVACHCINCKKAGGGSFSINYFINQDDMTIEDPSQAMKIYSDPNTSSGNTIQRHFCSSCGSPLFTLSPKVPGKAYLKAALFDSVSKPESVFFGDKRDEWVAINTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCH8</accession>
    <name>A0A370PCH8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_304290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCH8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="43179" checksum="64151D3BFE580180" modified="2018-11-07" version="1">MCYSTSTALSTDLPQWTLLDAPWDGVSKCPFLSSSALLLKTEHPVVGFSRQDPVDPSVLAELPKGNRVISAEEHGISFWGTTGRINVELADGTPVSFFIKATTKERGKNMVYGEYESMKAIYNVAPNFAPKPIAWGSYQDCPDTHFFLCEYRDMAADMPDPDKFAAWLAALHNNSASPTGKFGFHVATHNGNLPQMTDWEDSWEVFFANSMRHALDLETAVKGWDPELDFLVPALFERVIPRLLRPLESEGRSVKPSLIHGDLWYANSGIDTETGESLVFDACCFYAHNECELAGFYGEGTETDRWDTNEDEFGQWRPICNRFGDEYLEAYRSYAQVSPPEEDYDGRLDLYKLQEILNDIRDLVARYGSGVEYEASEASEGRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCP1</accession>
    <name>A0A370PCP1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_238288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCP1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="567" mass="61048" checksum="E756C8DB3FDB368E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCU0</accession>
    <name>A0A370PCU0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_277884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCU0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="344" mass="35811" checksum="BAF79A4366ADDAF1" modified="2018-11-07" version="1">MAPTNTAAWLKSEKAYPLEIDTAPYTHPGENELVIRNHSIGLNLVDYARQDLGSALFAWTPYPAILGSDVAGEVVEVGPGTISSRFKPGDRVLGLTGELKSTRSCQGAFQTYVVLKAHMTSPIPSNLSYADAAGIPLGISTAACGLFQKDYLALQHPIAPQAPSTGQTVLIWSGSSSVGSNAIQLAVAAGYEVITTASPRNYDFVKSLGASHVFDYKSETVVEDIIATFAGKSSAGALAIGTGSPEKCGQIVARVEGRKFVALASPPSGPLADGVESKFVFGGDLAENEVGPAIFVDFLPAALKEGSFVSAPKVEVVSEGLESVQEALNVLKKGVSAKKLVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCX3</accession>
    <name>A0A370PCX3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_237894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
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            <begin position="10"/>
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        </location>
    </feature>
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            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK40043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="877" mass="98427" checksum="FC1CDDB385B1609B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ9</accession>
    <name>A0A370PDZ9_ASPPH</name>
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        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="82"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <end position="368"/>
        </location>
    </feature>
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        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="98199" checksum="3A749D2774970B87" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE47</accession>
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        <submittedName>
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    </protein>
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        <name evidence="6" type="ORF">M752DRAFT_39700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00092">
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    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016604185" evidence="3">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="37227" checksum="74D0C1F3DF9622BD" modified="2018-11-07" version="1">MILSALWLLPTVGLASTSAIPASDAATTLDPGLFSGECTPEKMTIRKEWRNMTKVEQQSYLQGVNCLMDLPAQTGLEATTNRFSDLQALHRALTNTPVGDIIHSVGQFLPWHRYFLHTYETLLKEQCGYTGPMAWWNEAYDTDSGNMFRSEMWDADAFGGNGTEPDGCVTDGAFAYYTEHIGPQNQNTVFCMNRSWGNFEAIMNTTGAAVAHCNTFDSYDEYFACIAATPHRGGHWAVGGVMEDVKTSPGDPLFYLHHGYIDRLWYRWQMHDPANRLWDMGGPAINESANVEPASGWPQTTLNYTLTTFNIMPDVTVADVMNPVGGYLCYNYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PED7</accession>
    <name>A0A370PED7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_34069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PED7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="71" mass="8149" checksum="7C7ABFC20EB69347" modified="2018-11-07" version="1">MSVRFYHVAVLLLMEADDPMTALRIAGELESKQSCYHHSTLVDYKRKRSVLPTIDPYWVALSNQKRAKGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF3</accession>
    <name>A0A370PEF3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1774-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="293" mass="33080" checksum="34DD9EBAC476CCB1" modified="2018-11-07" version="1">MSTYNPFSRRESHGRFSLRTYRVLVPLSWLLVVVVGIYYSSHAPDVKHGHTIWKQANKHITPFSLSTVIAGIYWIITLLSQIGFVYHLFSNDAVTATAAANVGSHFILNNLFIFAWILLWTRNHFWGSEIILIAHFLNQKTTYWRHRTLPPLAHFAAVAAPYAWTLITLFWNGAVAVNSNSLPARIVANVFIWVLFALGSTHILSTQDDILGYSLSLLTLALAVKQFGVKVISLQWIFAIVIFAVFFAESLYISLTKYSGRNIFFRRAGQPAPATDREREPLLNDSTQPAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEL7</accession>
    <name>A0A370PEL7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEL7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744528" description="Six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76561" checksum="C4849B328648DD38" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF15</accession>
    <name>A0A370PF15_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_253965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976883" evidence="10">
        <location>
            <begin position="23"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="521" mass="58649" checksum="1E4ECDC5E0944799" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFH6</accession>
    <name>A0A370PFH6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">M752DRAFT_217306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFH6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="315" mass="35336" checksum="49CFC1698A7B30E0" modified="2018-11-07" version="1">MSSRTVWRSLQLQARRRFIVPETPYRCFSCTRRAQESPKSNQDDRMTHFGFQNVPEAQKESLVGAVFSSVASSYDVMNDMMSLGIHRLWKDHFVRSLNPGSALPSREHDTAGRGWNILDIAGGTGDIAFRMLDHATNINNDHETRVTIADINPDMLAEGQKRSVQTPYYNTNRLSFMQGNAQSMPSIPDNSVDLYTVVFGIRNFTDKQAALNEAFRVLKPGGVFACMEFSKVDNALFNAVYKQWSFSAIPMIGQLVAGDRDSYQYLVESIEQFPSQEEFRGMIQKAGFMIPGRGFENLTGGIAAIHKGIKPLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG60</accession>
    <name>A0A370PG60_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_217664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="389" mass="43489" checksum="B31719206BB7C8D7" modified="2018-11-07" version="1">MAASGVPGPTRARLWSTITAKRQEPIPRAITENVRRGLRAQPQNNPLTLTILVQMDKTLTPLAASDSLRRSLAEPGKVSLFKWTVDAFTVTVSDGAFGKVCLDMFPEVVDTMFLLQTNIYSIFTRRPRILAPKAYAASDKLACILAKYFALPTEKKLDCAEFVTMTEDEIRAAAVTKEELAMIMLDNPSTAAFWVLCRVLYNPELLATIREECEEAFERNKPVAPSEIPARLECCPILKATFEETMRLHSGTHVFRHISENTEIGPYRLRKGSNILIPYNRIQVSKTHWGPDAEEFKHRRFLDNPGLANSRYFRPFGDGTHQCGGKIMAPQLVMYFVAIVVCRYDVGIPGGIENCPFPRVDIPKGRATVPMPVAGDVPHVTITPRKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG94</accession>
    <name>A0A370PG94_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_217448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="30852" checksum="3164725524B873F4" modified="2018-11-07" version="1">MRPFGILPQNKTPDYEVRLLLEPAEILTPSIQLTNDVQSTFNMQPSATKESIEFFDTPTKEIFEAGWSVSARKVQGEDTIEFTYKHHYPITNNDIDSALTHANRHGFNNEPTGDSREFKAQVEWGYENKVLSMASKKKLDGFLADELDFLSADSMRQMLSTEAPNKFRHWKIHDWGTYALQRSIIYGPILVDRYSGSWDNKPINLEVWYMVNPSASRTDYIVEVSCKTNNRASALFKQRRLVDELKSKGWLVDEDLRKTEAILDAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGA0</accession>
    <name>A0A370PGA0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_303058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="545" mass="58400" checksum="E53DB17670CBE6A8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH4</accession>
    <name>A0A370PGH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_337037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="684" mass="77498" checksum="D93FD46385F36C42" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGS9</accession>
    <name>A0A370PGS9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_266933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGS9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="302" mass="33655" checksum="F655C0A5D9D0A534" modified="2018-11-07" version="1">MPVFVCGATGTQGSAIAKYLHENGIKVHTVTRTPLSTKAQHLRILGADVTAGDYDSEASLRASLANCTGLFLNMVPDFQNPDNEVIRGRRLLTLAKEAGVKHVVYSSAFAVNEPHKIRTFTPTGFIGKMLLPKQALENELQTMGFERWTILRPGSFMTNFLAPMVYMYSGLVDKGCWITAWTTETKIPLVDPMDIGKLGAMALTDEKFHGKEIEIAGELLTVEEIVDQLRKATGRDLKAAYLTQEEIEVQAAVNPLIEAQLAMRDMAQFANLEKTNEWNLDLGTFERFLKREKEKVVRTFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHP4</accession>
    <name>A0A370PHP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="233" mass="26896" checksum="9384A7126531A69D" modified="2018-11-07" version="1">MSPTTENKRCQAYEHLINIFQIHSPYLDKQRILNIYIAPEGFLRTALRVNPKARAIGFSLLRYEEDHNILLSKYPNISVKFIDITLLTADMGLLEIPNNHPDTGKFLPRQFESGQAFDLVIYNNQVLRNHDRATYHKHQEASRLTLTQLALGLEHIKLEKTMIILLHKHPRFHAKRSSFYILTTNIRTDCPDAAMAIQGTNNIYNQALQHNVPDINLILKNFGPRLAVLDKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHS2</accession>
    <name>A0A370PHS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase regulatory subunit Gac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_234783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="316"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="704" mass="78270" checksum="7B8C8D79AF8B5840" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHZ9</accession>
    <name>A0A370PHZ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_276531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
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        <property type="entry name" value="RFC_lid"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="276"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <begin position="456"/>
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            <end position="1031"/>
        </location>
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            <end position="1044"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK41810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116938" checksum="5AFE9771CCB0594E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI52</accession>
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        <submittedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_216611</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="511"/>
        </location>
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        <location>
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            <end position="485"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="583" mass="62247" checksum="D39E9E42225C40D7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIA9</accession>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">M752DRAFT_276989</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
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                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016778200" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="383" mass="41584" checksum="8D36EBE6B603FB3B" modified="2018-11-07" version="1">MIRLLLHTVIFLFVGLSRAAIVPLPPSTGPCDVTLQASELVDQARTNPFDLKGGKRALMVTTFTPVNCGSVLSESYIPNATAAYEDESFQSLGLAAGTFESFRIQTQQQPSPSSINGSYPIVLFSPALGTSRLVYTSLLQDIASYGFAVISVDHPYDANIVEFPDGRTVIGVLENTTTDAQFTWAMNVRVQDMIFVYNRTRNETAVGDIFPLSLENPHLLSLDRVAITGHSLGGATAAQTMLVDNRFVGGINLDGTFWGSVLTKGLSSPFLLFSNANHTAATDPSWGTFWSNLRGWRLELRLAQSKHYTFSDFPVLLDSLSISDELKEIVQASYIGTIGALRAKNVIVSYIVAALQYFAYGRTSDLLSGPSAAYPDVTFVHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIF5</accession>
    <name>A0A370PIF5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_235203</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="474"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="785"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1269"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="17">
        <location>
            <begin position="1495"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="15">
        <location>
            <begin position="1781"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK41960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1992" mass="223676" checksum="B0C284C37673075A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJI5</accession>
    <name>A0A370PJI5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_326943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="29155" checksum="06DCB8F35F796282" modified="2018-11-07" version="1">MEPGTPSETAFYSACIDGDLRKIRKVLANGLPTRTLEHGLSLATGAAHPDVVAALFDAGAPMTAFAIDALGGRDGEQHPDVVRHYLNRGLNPNRTTSDREPLLRFLNAAPARELLLRGADPNRRGPKKVAPLATALEIACKDDTSLFNLFVEYGANIEPSLFFRAIRPRGVDGEFKTKFLLGKGLNPNTTSPEWGTPLHCAVYIAKEEIVKILLDAGADPAARSKCRQFGDKSPSEVAETRMKYTTNVPDLQASFLTILELLQNYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJW1</accession>
    <name>A0A370PJW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_276333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJW1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="45969" checksum="25CB637ABF337066" modified="2018-11-07" version="1">MASFFQTPSLVYTSAIALRAILLIYGAWQDANSAVKYTDIDYLVFTDAARYVSHGASPYERDTYRYTPLLAWLLLPTSWSGPSFLFSFGKALFALSDVLAGWLIARSLVSAYGMDAPRALKYASFWLLNPMVANISTRGSSEGLLGVLVIALLWAVLRRRVVLAGVLLGLSVHFKIYPFIYGVSILWWLDRERDGSSSSTSKNNAGDASIITKMINFITPSRIILTLSSLITFSLLNLLMYHLYDTPFLQHTFLHHLTRIDHRHNFSPYSTLLYLSAAGEVQGNFESLAFIPQLLLSVVVIPLVLAKKSLPGAMLAQTFAFVTFNKVCTSQYFLWYLIFLPFYLPRSSMLKAPRFGGAVAAAWVVGQALWLQQGYNLEFLGLSSFVPGLLLASLGFFAVNVWILGIIVEDVGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJW3</accession>
    <name>A0A370PJW3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_283822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJW3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="31953" checksum="D90FB90A7E0D1FD7" modified="2018-11-07" version="1">MFTSTKTTFTPSTDIPSLKDKVIMVTGGNSGLGKQSIVELAKHRPKEVWLAARDPKRAAAAVTSIKCDLVEPVDIKILDMDLTSLDSVKRAAERFRSESSRLDILLLNAGIMSVPPGLTNEGYEIQFGTNHMGHALLAKLLVPVLLKTATLPGSDVRVVVLTSHAHNYAPESGIHKLANLLWGREMARHYPQLTVPLVHPGLVRTNLATTMGQGSLIMRILWWIASLVTGVDVETGTLNQLWAATYPRVESGQYYVPVGKTRNGSKYAQDLGLGKKLWEWTEMELEAYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJZ5</accession>
    <name>A0A370PJZ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_16969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="582" mass="64174" checksum="973EE01C411307E4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG7</accession>
    <name>A0A370PKG7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKG7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="147" mass="16906" checksum="AD5932D7265BF80A" modified="2018-11-07" version="1">MTTSKPLIRFDTYVKRHPSLTVEEFHHTWTTSHAQLLKTWLARHGVYRYTLFHTPPDVAKQYLGQKHAGGDHVMESFDGHAEILLESWDILGRLRADPYYVEVVEPSEVTLVDKASVVRRVGYEEVWVAEGKAVHQTKFAHPDSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKM3</accession>
    <name>A0A370PKM3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_315087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016587930" evidence="6">
        <location>
            <begin position="21"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="547"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="66170" checksum="D1D6B89E89964FF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL57</accession>
    <name>A0A370PL57_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_250928</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL57"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="497" mass="55849" checksum="22102FEABE57FB17" modified="2018-11-07" version="1">MAPKKDSKTKVRVQPVPEKRGYEFGGPLGAFGIVFGLPVLVYSFTFLCNDVSGCPAPSLLHPSTVTLDQLKAEVGWPKGGFADFYDTSVTLWVLGYYLLSLAMYVFLPGQEVEGTELACGGRLPYKFNAFLSAVLILSGCATGTYIYGADFAVWTFLWDNYLQVITANLVICTVISIFVYAKSFTVPAPGQPNPELRQLAPGGHTGNALYDFFIGRELNPRVRLPIPFVSEASRTIDIKSWLEMRPGLLGWIILNLSNIARQYRTYGYITDSIVISTAFQAFYVLDGLYMEPALLTTMDIIMDGFGFMLSFGDLVWVPFIYNFQTRYLAVFPYELGFNGILLVLAVTAVGYSIFRGANNQKNRFRTNPNDPRVKHLKYIQTASGSKLITSGWWGSARHINYLGDWVMSWSYCLPTGIAGYAIIQTINPATGDLQKQAVQTPESRGWGMIFTYFFLVYFGTLLIHREQRDEEKCRRKYGADWDRYTSLVRSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM33</accession>
    <name>A0A370PM33_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Camp-specific phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_314412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53443" checksum="D211F996FC078E73" modified="2018-11-07" version="1">MQASELPFVGANPPEAASRGEGPGSPSLQIIVLGPTGGPREDRVTGLLVRSTSTKWSANSIVAVDAGTLLCGIIDTLEPCDNNKKLSDQGPFAGLELPHNNVPANAAHVFRHIIGAVCITHPHLDHLSAFAINTPVLEAGSGAKTLAALPSVVAAIKTHVFNDVIWPNLSDEDGGAGLVTYQRLMEGGNPMMGRGDEKGYTRVCEGLLAKCLAISHGCCRQRSSVDNDVQRRMSSAPFGVDPMRLNPRAFSISFDEPETGYFSGARSPGYRVPGKDSWATVESSAFFIREPTTKREVIIFGDVEPDSISLNPRNRRVWEAAAPKIVASQLRAIFIECSYNDDVDDASLYGHLCPRHLIDELIVLAQKVTELKYPDSFSVRKRKRASAPEAAGDPALSPKSKKAALAGEKGGGSRSPAVSHAPSEVGMDVSLAESSDPLTVLQWPEPPLAGLLIYIIHIKDDMNDGPPPQERILQELTAQGQAAGLGCEFRVPTRGESVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM85</accession>
    <name>A0A370PM85_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_155698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM85"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="80" mass="8589" checksum="D397C9428E003DCF" modified="2018-11-07" version="1">MAMKGDTACLAGIACGPMTLTTRLIVAHTDAIGEGAKPVFKYCGGNSHQLWHIPRLWVRQLLAGWAAYGVPLSCLTKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMN2</accession>
    <name>A0A370PMN2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_326267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMN2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="614" mass="66893" checksum="D299904B6114726F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNV2</accession>
    <name>A0A370PNV2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="34725" checksum="FB083BA35D3D44F0" modified="2018-11-07" version="1">MQILITGAAGFIGQLLAKELLNDPSYIVTLTDINEPPIPTGVAYPQNARSVTTDLLKGADAVVDKSLDAVYAFHGIMSSGSEANFDLGMSVNVDATRNLLEALRRTCPGVRVIYSSSQAVYGQPLPEVVNDSVIPTPQSSYGAEKIICETLINEYTRRGFITGFTLRFPTISVRPGRPTAAASSFLSGMIREPLDGKECVIPLEDRSFKSWLCSPKTLVHNLVHTFSLPKDALPPHIRQINVPGICVTIQDMMDALEKVAGKDKLGLLKETEDPTLRPILESWPTRFDNSQAISLGFKRDSSFEQAVRDYQLEIGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP11</accession>
    <name>A0A370PP11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_326435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
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        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="319" mass="34264" checksum="58B99A2FE7914A3F" modified="2018-11-07" version="1">MDQIHTRALEALQPFIHLATSNSATSPRFITNLITNATSNPNTYVFAELLTTPAIQSLRDPNTPAEYASYLTLLEIFAWGTWQDYQSTPNLPPLNDAQTLKLRLLSLLSLSTTTNPLTYNTLMTALSITQPSELESLVTKAIYASLITARLSPASNPPTVNVTSVAPLRDVKPESLGKMIDILTAWETRCGDVIGDIEAEIVRIKTESARRRAEEREKEVLFEKALAGWGAKMDEKKVGGGGGGWQQGGRGGGVIGGNKREFAADELDDDGYWEYGLEGGDGMGGGGSRMDIDDGAGARLGGASSGPARHPKRVLGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP46</accession>
    <name>A0A370PP46_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_282666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP46"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="36058" checksum="A9314C6C18F18664" modified="2018-11-07" version="1">MLSQALATHERRSNTPFLLSKESFDTHVHVFDPKLGPYAAGRAYTPEDAPLQKLLALNQSLTRSYNNTTLVLVQPSPYKADCSVMMHCLRELKDRGISSFGIAVLDLNSTTNAQLSELHALGVRGVRLNFQADGKEVDITHLVAILNHTADRIHHLPGWAIQLFVPGWTWDLLYDAVRELPVRVIADHLGGMRGASKLPSDLQSTPTSQPGFRSLLSLAKQSIVYVKVSGLYRMSNCLASTFDDLQPIVQVMASEISNQIIWGSDWPHTGDGHERVKHSIENKEPFRTIDNHAILQRLYDWMGDDAYWKMMVDNPGRLYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPT3</accession>
    <name>A0A370PPT3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb1 C-terminal repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_211487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038799">
        <property type="entry name" value="LEKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251:SF1">
        <property type="entry name" value="LEUCINE, GLUTAMATE AND LYSINE RICH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251">
        <property type="entry name" value="LEUCINE-, GLUTAMATE- AND LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="700"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="145611" checksum="D7C6BB38CF892509" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ33</accession>
    <name>A0A370PQ33_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_274660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:histone acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
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    </dbReference>
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            <end position="428"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
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    </evidence>
    <sequence length="1126" mass="125434" checksum="ED5B9480AB09E80D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQL9</accession>
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Sandor L."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <ligand>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05199"/>
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    </evidence>
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            <dbReference type="EMBL" id="RDK44451.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="691" mass="75577" checksum="2C1F576C264C1CA5" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR71</accession>
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        <recommendedName>
            <fullName evidence="3">Mucin-like domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032059">
        <property type="entry name" value="Mucin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16058">
        <property type="entry name" value="Mucin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017077073" description="Mucin-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Mucin-like" evidence="3">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="182" mass="17912" checksum="2BB43E1043755118" modified="2018-11-07" version="1" fragment="single">MVKGGVAFLAFAGPALAGVIARGGEPGGEPQVGTIVGTNYPVATGTAPPPPPPPIQFPTGTAPQPKPTTSHGTAPIKPTTSIGTVPIKPTTSHGTAPIIRPTTSQGTAPIRPTTSFGTAPIRPTTSFGTAPIRPTTSSGTAPIRPTTSSGTAPIRPTTSSGTAPIRPTTSSGTAPIRPTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRE9</accession>
    <name>A0A370PRE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_274795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="53621" checksum="336849B64E0E698D" modified="2018-11-07" version="1">MAHIENLQGLIAQSLLLAAFAIVSAIFCRCFYRIYLHPLSSVPGPKLAACTSLWLAYHTYIGDECTVVCDLHRKYGAVLRVAPNDVDIADKDALEPIYIARGGFPKTPAYSKFDIDGHTTIFSSLTLPERATRAKAVAPLFSTASIRSSQEALREVFDDFAKRLQAEARTGRPVNVLNVTRAMAIDAVTTYLFHERYGAITEKTESMSASPFVDSFAGVGAFFNIVPGKIGDFVMEVIERWSTTKNVEQSHGLIDQYTRRLIQTAIPKSGSYQSRLLEKSTIAQSQIELKDVCFAGTDSTGMNTATILWYLAKHPEIYDRLRQAVMESINNDEDPTACAYLRGVVREGLRLSWANPIRLPRAVPAGGWKYRDYYFPAGTSVGVAAFQLHQDSSVFPEPQRFHPERWDNADDEMLTAFFAFGKGTRACIAQSLAMYEVTMAIFTVVKADVLRGASIVGDRIEIKEWFNSKVKGQEILIQFASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRN8</accession>
    <name>A0A370PRN8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterigmatocystin biosynthesis dehydrogenase stcV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_324838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="42440" checksum="A56F3ED32C0E1645" modified="2018-11-07" version="1">MAGPVPKPEFLLGFHQVLSPTGGIKVSPLCLGTMNFGTTWEPYMGECSKEESFAIMDTFFDHGGNFIDTANVYQDGQSEQWIGEWMKKRGNRDQMVIATKYTTGFRRTHVSTEPIQSNFVGNSVKSMNLSVKNSLEKLQTDYIDILYVHWWDFTTSVEEVMHGLNALVLAGKVLYLGVSGTPAWLVVKANAYARANGLRPFSVYQGKWNAGFRDIETEIVPMCRDQGMAIAPFAVLGQAKFRPAEQRNAEYKGSGRAALRAEEDDKVSDVLEAVAKRNGTTLYAIALAWVRFKAPYVFPIIGQRSAAHMKANIEALSLDLSKEDMDEIDKATKFNPAFPLDYLLAENFSTAFTAADVQLTKWTAHIDAPTPVMPVRPRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS42</accession>
    <name>A0A370PS42_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_247720</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YME2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000959">
        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="21">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="1319"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK45013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1376" mass="154629" checksum="E1EF5864656AFC56" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSK9</accession>
    <name>A0A370PSK9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_274452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="688" mass="75622" checksum="EC2FE6060CC0407B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSN3</accession>
    <name>A0A370PSN3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_134018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSN3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12751" checksum="9F86B37B3C654F50" modified="2018-11-07" version="1">MIRCKIGGFYFMPLAFSFSFFSAFSSFLLFFFLINFSFPPYSFACCSSPPLLKCYVSRSKVWLKQPKVDKLEFMGCFLVFLFPKGGEKDGVLKCMIKLQCCFCCCLYVAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSN5</accession>
    <name>A0A370PSN5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">M752DRAFT_334058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSN5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="629"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="828" mass="90301" checksum="17D86ABF6CA0BEF9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU26</accession>
    <name>A0A370PU26_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_324534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="223" mass="25314" checksum="4045F26B30A35FAB" modified="2018-11-07" version="1">MSRNYASLADQSIFLAFSDLPGDYTCPQIGGGRYGCLLLEIVSIERFTRLVLRTFDRADLPVTVAFYTEDRGRSIENDPKLKPGNTMAILFPRRHLFLDGTVGVRQEHYGYSKLLPGKLNILFQLSDEMRSWPAKFATHKICHGCGEKDKPLLRCAKCGVVVYCDKECQKAGWEEKGHKKTCKVIADRGFRTLVTRPNCTTDPVAQLSFRMLREAYERGLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU58</accession>
    <name>A0A370PU58_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase, alpha subcomplex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_121202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU58"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000219">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="94" mass="10683" checksum="F4DBD16B0DE383AD" modified="2018-11-07" version="1">MSSKYVFTKGLKELRFLFCQTSQASAATRSFLQRAYPTMKKHNPYTPILMREAAGTVPRVYARYAFGQEKQEALTGLTDQQIEEKITQLVKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUD4</accession>
    <name>A0A370PUD4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_123680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017060178" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="232"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38269" checksum="61200F2A34BE2034" modified="2018-11-07" version="1">MRSLLLLLAAIALTTTAQYLKDINPTPVDYPVHVEFVPDSTALADLEAPKLSEVNTTVFEWWYFDAVSSANPNASVVLTFFTTTATAFPAVPPNSSSVLLTYAWATFPNGTTVVQSAVPIDASVMGDRDVNSGGWEGTGGWSGKESGYEAWVGWQGSRVNGSIQLRNPTPPLLPCSTPEQVNRALGLGEGLGWVSMVPDSYATVDLMVDGEKLQFTGYGYHDKNWGNRPFQNTVKTWSWGHVHIGSYSLVWLQYTPRVGADNSTTPIRSAYLARDGKVVQSGCRTSIISIQERMTSSSYAVDVMMSGVDLQIQGTVEVAGDGKDYFRWNGVVLGTVEGQRLDGGVAVFEGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUE3</accession>
    <name>A0A370PUE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_311950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="373" mass="42723" checksum="56CF9AF47AD910C7" modified="2018-11-07" version="1">MPARLIDRYDHVPVTKENLDWAELITLDLSQYDQPGGKESLVEQLDHAVRHVGFFYVKNFNISQEEIDRQFALGREFYALPLEEKLKYHSSADLDRGEYNGYRPAGHRILGNGIKDNVQVYNIPKFDGYHQRQQPSILADNIDEIEQFSRKCHTEVVEKLLRLFAILLELPDEDQLVRDHQYDVKGEDHLRYMHYAARGAELNKKVGGLYSPGHTDLGTVTLLFRQPVAALQILNSEGQWKWVRPQDGTITINTCDALTALTGGLIKSSIHRVHVPPADQAHVDRLGVLYFARPNNHVVLDPIKNSPLLNRLGLTQNVFTELGQHLTTEQWVKARQTQQQRRTREAKVSEDGKYTYGEKDLQILPGLDAKVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV37</accession>
    <name>A0A370PV37_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_96552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV37"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="296" mass="33120" checksum="26C166B48938FF19" modified="2018-11-07" version="1">MAEYWKSAPKFWCKQCKIFIRDTAFEKSQHEATAKHQGNLKRFLRDIHRNNEQQQREAQRAKNEVERLRQTVAGSAGGKDGDATPWKRAPAPAPKPQERPVSLEERKRQMAQLAEMGIAIPEEYRSEMALAGEWQTLSEKVVQPSEESKASQSLGVRKRKHEERDEEEEEAKQEAERFVSKGWGSRTRVYPGAQEDTDLDALLESTKDIKKGKSAAPAESAPEPEPEKASDSVKGQFLPVKSEGDAAAPETGEPSQVKQESETAPSEAAPVTKEELEDAPATGVVFKKRKAKVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVJ5</accession>
    <name>A0A370PVJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_262533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1686" mass="188664" checksum="1C4CEACE2BEE53C4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVX2</accession>
    <name>A0A370PVX2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_317356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVX2"/>
    <dbReference type="SMR" id="A0A370PVX2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="203" mass="24162" checksum="8EDE8E2B412A0F84" modified="2018-11-07" version="1">MGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNAIHRASRPSRPDKARRLGYKAKQGYVVYRIRVRRGGRKRPAPKGATYGKPTNMGINQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYFEVILVDPQHKAIRRDARINWICNAVHKHREARGLTATGKKSRGINKGHRYNNTRSGRRHTWKRQNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWA7</accession>
    <name>A0A370PWA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_289978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="56669" checksum="7FF9703BB40538BC" modified="2018-11-07" version="1">MDYIAPSLISQLSSILQNPSFPAHLQSAVHALRDSLDSKQKSASEKENDHPQLHLRIEASIVTDVTTSKQTSDLVLGYIDLRSGQAVPLPPTPVSTPDSTINTEYATISTDSNGGRDNSTAQSHPHKRRKTVSALRPAKATTIQPNESRDHEYESLDLEAVADSSGTKPFVRQVHSDTRFPQRKNPRQEYSLPVLEPTSADKLIAGIWRQLHSPVKLSRLPSIIQSNTDIRTGVSLEVFREINTLCLKYYNQSQSSRALEMIVQAYWIECFEARVAVVRLEKPHLSTTDARMMVLKEACVVLNWKEKDLRNRMAIWRGYKEIKDTGGWACLIFASTGIYRFCKYRTEFGEGLFTRLRHLQSSFEVAADTLHPGWRDLLQVIRQNTSCVYHGHPHEWVNMSEGAAVPLASTYEHLDLPQGLQYQFIEECVLDRTHFGTHDPRRVPELDPDLCLVCKERQSDEIQKNQCLCFPALFGGVRHPVPVQVFRTSTGKNNGVIARCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWM3</accession>
    <name>A0A370PWM3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_290077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="31329" checksum="9C3D4B1162FF3778" modified="2018-11-07" version="1">MSSDQTASYLPTPNNVQPTKGPRYKRKYLVSILLGTISLVAIIVAVVCLSVLLPKKLKHDNNHDGGNHNTGVSTTQGNDTHSLDPDGSTYNGGGVQNGTGTHTTGATPTGDVPHQPSATSNGEDSQRPNGVVNVTDTQPVQGGSQSQDGECHVVSKVSYTFYGYPDNDPPGSDISEDCGRGMAAGGIGTHENPLTFATAPGEFDRCEVVYSPYLQKYLINEDYCEQCTKDWKSHIWHVDVWLGGNSTTYGTEQLKCENSLTSAEESQVVIKNPSSNLPVDREFLYMLMLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX71</accession>
    <name>A0A370PX71_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lectin family integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_332103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000245">
        <property type="entry name" value="Similar to lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579726" evidence="8">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="45663" checksum="3A170CE9F53F9EEC" modified="2018-11-07" version="1">MMKIPVSLLSLVAAATAQSVIESSSFGFGQTLSADGGAISGWQTGGESHTPDILSNKIILTPPYPGNTRGFAWSQTPVSQSEWTAEFQFRATGPERGGGNLQLWYAKDGKDRIGTSSIYTVNQFDGFALVIDSHGGRGGSVRGFLNDGTTDYKSHRSVDSLAFGHCDYPYRNLGRPSTVRLKHTKSIFEVTVDDKLCFSTDKVALPTGNVFGLTAATPENPDSFEVFKFVLQSAESGTGSAVPVQQQNTNQQPIAAQQQAVPQQQQQAPPVNTGFEQQFADLSNRVQVVNQATDNIIRELGSQDTKAANRQVELLQKLASKEQIASLDARLQRMEQMLQTIQRDLEGKDYHSRFNQLQETLRSSHLSLTENLLGVITSSAPRMGFFICMIIAFQGLLAVAYIIYKRRRANMPKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXP2</accession>
    <name>A0A370PXP2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_272733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXP2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="732" mass="84827" checksum="899D81EF0B593EBE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXV9</accession>
    <name>A0A370PXV9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_245141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXV9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016654835" evidence="1">
        <location>
            <begin position="25"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="591" mass="66152" checksum="28B9E940380F5681" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXX7</accession>
    <name>A0A370PXX7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_68543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXX7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016935759" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9838" checksum="E97B3BCA39402780" modified="2018-11-07" version="1">MWLLRCANCHGYVCLTMSSIILIGDALFSCPSTDTVERISLDSLYPSQVQTRPSVHQIPARRCDPSSKQTSASIWLAALLHVRTYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZG0</accession>
    <name>A0A370PZG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_260937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF10">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="32971" checksum="D8A9D104E7B0340F" modified="2018-11-07" version="1">MISTWQAPKDYRERPVVVLGGGVLGRRIACIWASAGYNVHVRDPSPEQRADCITYVNENVASYAVHTGAKPGPITAFEELAQAIENAWLVIECVPEVLQLKIDTFAELEKHAPTDCILATNSSSYRSSEMLEKVSEATKSRILNMHYYMPPQVMVVELMTDGFTEPSILHFMAERSKEVATKPYIARKESTGFIFNRLWAAVKRETLTILAEDVSTPSEIDSLWTEMFIKGKTLPCEMMDAVGLDTVAFIEKHYVAERGLDTEKTVDFLQTNYLSQGKLGNKSSKGGLYSPAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q056</accession>
    <name>A0A370Q056_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_331593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q056"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="509" mass="55850" checksum="797AEFBFEAB15A43" modified="2018-11-07" version="1">MAEVVAEIVANACHLEQEKATHIETLLSRFDSLSAAEQDQERASYVAAVFPLFFGAAAVVHGSNGYEPQRIVPWSTNCWLQPRVIVRPGSAQQVAAALALCRFFHVKFSIRGGGHLQIPGFTSNQDGVVISLGAFDQVRVAEDKSTAEIGVGLRWLEVYRALEEHGVAVAGGRVPTVGVSGLLLGGGISFQNSQYGVGAMGVCNYEVVLANSQIINANARENSDLFWALKGGGPNFGIVTKIEMNTIPNQIWTEVRIYPLTAADQLRAALMQYHEAIETDNRASLIWNATNDIILIVYFYCAPVENPPVFQAFYDIPFLTSFVPPGIRTVYDLVQAVASVNEAEPTVHEFRTMSSRPSLEVYKAIEQAHAEQAEALKDVEGIALTTVIQPMSSLAMRETLKNGGTPLGLEPVGQQWFLARADWKNIQDEERVREAVRKIVDAAESAAKQTGVYLPYKYSNYAAWDQDPLASYGAENVRRLKEVARKYDPEGVFQTLQNGGWLLSKVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q088</accession>
    <name>A0A370Q088_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q088"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42525" checksum="749AB129C7DD9F8D" modified="2018-11-07" version="1">MAHDVRDSHLQPPDAAPLSDEQLSEQPSATEWMSAQSNHSTGALHSDNDIVHPHDAVDYSAGHSRSPESTVVGEFDNIPAMGKKPRTLPAWIRSVEYTEDEADAAVTDRLLPSQPGEAVVAQHNHSPYAASRPTLSSGQGESSRGIIGRERESRWKNFSRDIAYPREQGVQEKPVTPDWLNENLGDYSEPWRGQGEPDEDTEDPLRMRRRREIWFKRFHNTLLKSPMVPLIFRLTVWCFSLTALALGGSIQHLSGKYQHPQGPSALMAIIVDAVALVYLVYITFDEYTSKPLGLRSPSAKARLILLDIFFIVFDSANLSLAFESLSTVRGACTMAEVNQEVAPKNDAICDRQIALACVLLIALLAWLTTFSISVLRLVERVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q093</accession>
    <name>A0A370Q093_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein fta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q093"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="234" mass="26756" checksum="3B70E565AEEF385D" modified="2018-11-07" version="1">MESTRTISELKSSFIRAQVRILSEGLEPAEDWRNYAAETEEDDLSDKVVGDVLQKLNAALKQHSRIVYSSQAVQHVAQQITSLYWSSATQAIPNPGSLLKGVERSVDLSSHLNIAQLPLELENQSASEAQRARYQELRERLTDLDRLRQQRQRRLDQLRQLQQLLEPFREPQKNIQPNLVTRDGELVQELDKMRMLVARVGGRVEQGKKKLGAQEQDKPYLGCDQKLDALLDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0G9</accession>
    <name>A0A370Q0G9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_288391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0G9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5416" checksum="F75DE95C16D6649F" modified="2018-11-07" version="1">MFAPGQEQLSKEEIRAGEVQASQTIRMAVSGGILLYLSPFAIDFVKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0K7</accession>
    <name>A0A370Q0K7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_331706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0K7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="168"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="50322" checksum="06AE48B091CB71D7" modified="2018-11-07" version="1">MASNLPIPIPPRTPTPPPDDSPSTSNQSPRLQDKDSLSPLRDTFPNLRGSLDPSDANRLSPTRAGFNLSPADALQPSDQSDNASAGPFNFKTTTMAKSPVVKSNIGQRRGHKYKHSSISHQIFLEPPPRAPLALPNSLPIPTFKEYRSSMSKDQTTRFWWSVCHMSVAAYTLWSAHGSLAMTALSHLILFDSIGALLCVAVDILGNFEVWKRSSVRHPFGLERAEVLAGFAMCVLLLFMGMDLISHSLQHFLESSGHEPHHTHVHERVSLGRVDFTALLAISSTLISAIGLKNHGRIGKAMRFGYIESLPSVLSNPSHFLTLSCSTLLLLLPLVSIKLYNWLDVLLSSTISISMCVIGVRLVKTLGSMLLMSYSGPGVSEVIRDIEADPCVYGVDDARFWQVHYGLCMANLKLRVSGTEENLVRLRERVASLIKNRLGGGYGSGGQKWEVSLQFTAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0T3</accession>
    <name>A0A370Q0T3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_9483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0T3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976634" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9528" checksum="C7585773E4E31506" modified="2018-11-07" version="1">MCAIQSMLLMSCTPLVYACLDNGPTLSRNNCMSQANGHGAGWIVGSLVDVAVEASALSPEATPHPGSGVKYHTERDEINYRRGSSFPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1F0</accession>
    <name>A0A370Q1F0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1F0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="261" mass="28004" checksum="39B213DA298B19F8" modified="2018-11-07" version="1">MDPKMDPKMDTRKISAQRLPPPVLFQGPPSHNASNLSLPPPVSAVPSTGVSPRPPLQRNRSSRAGTLEAPGSLSPFLTRKQSKGEVDGSEAIWQEMQSALSEVELSAATGEHVFGEKHSEALEDLRTKQLKLAQAWARSEAGDEVVETKGAVAAAAAATAKSNASLRPASRSTAGPGDSANPDDGSSRNLDEETEKDILLARERREANDRYFDRVNNGVLDVVAKLEEVAQAMRAVERESKDIWSDTDSMSTTTQTTTDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1T0</accession>
    <name>A0A370Q1T0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_272281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1T0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="81" mass="9018" checksum="47B2D3BAFAA3DA0D" modified="2018-11-07" version="1">MDLQETRSPNSGQWVPLINHQTHATIHASGRSSRCQLIIVQLFIQQSGGEFKKVHEAALNGHLQMPEKENAYQPDKSPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4K8</accession>
    <name>A0A370P4K8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_280153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4K8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK36805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="458" mass="49078" checksum="474AC7387BF5839B" modified="2018-11-07" version="1">MGKKPSGPAYVLGVGMTKFIKPRGKVDYHELGFEAGVKAMLDAHINYDDVEQGVACYVYGDSTCGQRVFYQFGLTQIPIYNVNNNCSTGSTGLAMARTMVSHGAADCVLVVGFEKMSPGSLQSVYNDRANPTGLFGTMMAETRGITNAPGAAQMFGNAGREYMEKYGAKTEDFAEIARINHEHSKRNPYSQFQDEYTLEQILKAPKIHEPLTKLQCCPTSDGAAAAVIVSQAFLDARPHLKDQAILIAGQQLASDNSSLYNRSSIDLMGFGMSRGACRAATAEAGVNVKDIKVCELHDCFSANEMITIDALELSEPGKAHEMVRKGDITYGGKMVINPSGGLISKGHPLGATGLAQCAELVWHLRGWANNRLVQGTDAALQHNLGLGGAVVVTVYKRADGKVATPVPSDVVAKISGLGYNPAVEAKGFTAEQAKSVQSKNHSDTWALGDTQERVLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P518</accession>
    <name>A0A370P518_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Catalytic LigB subunit of aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_259359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P518"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="271" mass="30563" checksum="04C5B629CC3A27D8" modified="2018-11-07" version="1">MMLGEESTSADYWRRCGDEALVQGIKGVVIMGAHWACHGDGIEVATNPNPGKSPVAYVHPSKYVDYKLNPDLPTAHRCISLLSQAGFKATGNDTFEWIHDVYLILIRMFPNACPPTTIISSNARYDPHYHMKVGSTLRQLRRENYLIIGTGGAVHNLYRNRWAPMLRFRDNFAMETPPEDWALEFRQAVEDVMVKCPGGPKMRRAMTRLMKHPEYRDAHATDDHFMAALFVAGAVGEWEDEGSKVVLGAETWELTNMCNSQFTIGEWSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P525</accession>
    <name>A0A370P525_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_106789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P525"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="127" mass="14144" checksum="C8C104F241598CA6" modified="2018-11-07" version="1">MFVLDCESLGLNTVANPLVGRPHAGSVHHDGGLACSFLFIFHLMVLLIRHRPSNIRSDFCCRLVTPGCSCWSPWEDVGFSYLLLHRPIPLRLRKAACDTKPGQTRGQRGSRGLATTDYHSSRRGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P527</accession>
    <name>A0A370P527_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_259390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P527"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016584">
        <property type="entry name" value="MeTrfase_VrtF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011491">
        <property type="entry name" value="Mtase_YbcY_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="3">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="250" mass="28013" checksum="E61E32209CEA6600" modified="2018-11-07" version="1">MTASPKTPTSLNEGIALYTPFLLRYFYDFWVLWVSNKFAWKCSTSTVQLPLFNAAMGQSHLDIGVGTGYYPAKSLKAGAKCTEITLLDLSPNSLQAAEQRILETVGREAVRVNTVVASALEPLPFDKTKRFNSISVFFLLHCMPGTPEEKCKLFDVVRPHLAEDGVLVGTTVLGQGVPINWLGQKMMNSYNNNTKSFHNSEDNKAQFDEGLRRNFEEVDSWIMGQVMLFKARKPRQQDAITNVVPKDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5D0</accession>
    <name>A0A370P5D0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_280023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5D0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="32802" checksum="3E7CCEFB6A468323" modified="2018-11-07" version="1">MVKRKELKDNDVEMSGTDPRVDGDDSDEDMDMVNVDFEWFDPQPAVDFHGLKNLLRQLFDTDAQIFDMSALADLILSQPLLGSTVKVDGNESDPYAFLTVLNLQEHKDKPVIKDLTAYLQRKANAVPTLAPLAQLLSQTPIPPIGLILTERLINMPAEVVPPMYTMLQEEIEWAIKDKEPYNFSHYLIVSKTYEEVESKLDAEESRPQKKKKKAAGGEKAERFLFHPEDEVLERHAVCVGPVEYTHKAEEGLSDAKRAFQDLGIVTKGSLILLEANKLDGAVKDMAEYFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P681</accession>
    <name>A0A370P681_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_279651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P681"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="57"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="411" mass="45164" checksum="1DD69B71C9FBA5FB" modified="2018-11-07" version="1">MSQQPAILPRSAAHDNSPGSIRGFFIFITIITILSISLRFWSRCIRSNAGLGAGRHTQRLWWDDWAALAAVPWILGLCGVAFAMGFYGLGHHAQFVDSKDLAIFLRLLYAVYYVYDIGLFFTKLSAILFLSRIFPWHANSKWFNYTIVATHCLNCAWLVGIIFGTTFMCNPVQKGWNPTLPGHCGTTSALWLGSAIPSVIIDLIILLLPVPKIWSLQMTTTRKLGIIGVFVIGYSVIVVSLGRLTTVLLTGSSLNSDITYTVVHLAYWVGAEAPITMLCICLPPMTTLGRYLANNYFSKISSRVQSLFSTIKGSRGTVASRSYSAPDSQSQSIAMHRSSMKKSVDNDGHSLESQESSAHLFPHEDANYYAGARANVSYPRSGTHGTSPLPNSGDTGIRVDSIVTVTQRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6J3</accession>
    <name>A0A370P6J3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_270589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6J3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="373" mass="41339" checksum="9887EBF2CDCD0880" modified="2018-11-07" version="1">MVPTYASTLSIPIGLPPRDERAIEFTSDADIRIKGDTSNTLGQLNNHRYTKRWRISGFQCTQTATSWQHAPCGNSEPLLLIVYSFDAASRANPKSPSTSASFPFRRYLLTRLLVPLRVVADCLFDIIKKRTSFSGYSTSNRVLSSIVIVFLRFSARPSHPTPYRVRATRLPTLRIEISTKVRAPLLSETFYACQAALLHPDNTNTGQQHTRQTPYQNLSAEDTICPGTGTWKNPETGVLVGGLLNVALWFQSLKLGLSLSSRYWQSRASTGKSVAHVGFGVLILLEIKLLLGLGAVTPNSPLEYKLRGSIRATTPLCQGREGKRYQNEDFDASVHSAQGPLTADRTQAQLADRFEAMDNTVLVHLHKYMDAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Q9</accession>
    <name>A0A370P6Q9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_339600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Q9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK37558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="207" mass="22424" checksum="3BBEC2E1F86B0B42" modified="2018-11-07" version="1">MVRLKHRYILLDILYPDPSTWPPAASRTNKNPLSKSKSQAQLQIHSPTSDALTPGLLAKMVREEVSLMFGDYGVGRLGGAGAGGISVKYLSPATSTAIIRCPRASFRLVWTALTCMSQVPGFSEGGSKRTTRACVFRVIRVSGTMRKAEEEAIRRARREIVRLREAEESGVLEGLLGGLVDVAGEESTPVTGEDVVGDVMMESEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6S5</accession>
    <name>A0A370P6S5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_330369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6S5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000968">
        <property type="entry name" value="Aspergillus niger contig An11c0010, genomic contig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="31159" checksum="4E8C20F787CBEC37" modified="2018-11-07" version="1">MEPILHIQGDAHSSLTPLIFIHAVSGLAWPYMALGNLSNTSDPARSRPVYGISSPVYSSELQPHGPYLLGGWSMGGMIAVKMAEILQAKKETVQQVILLDSINPEKYPAFVNEEEHRIIADGLFTNVCQAMGMADLADNSDDEDNRSDASDASDDGSTMSDEEEEDDNLHRLFSTMRRHIHASTLSIASTEPGKLLPPNSVCHTSVTLVKCTQLSETVPALFSARQRCIRRCALHPTLQWRPQNFDRFRTLLIDARHDSLFDEEHVEEVTSMLRQILESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P740</accession>
    <name>A0A370P740_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_339503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P740"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017052423" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="11474" checksum="CE3090562EC3262A" modified="2018-11-07" version="1">MVSYKTLVLTMIPAVMAQNKTLIGTTTEFRVCTVDARPIYSETCIPLNQTGSTQFNVAVGCRQFGNTACTGSYDTVGYRSDCYQNSRFFQNFGTISGSIYCYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7B2</accession>
    <name>A0A370P7B2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_269993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7B2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16179" checksum="2B37309250CBE9A9" modified="2018-11-07" version="1">MPPSPRRPRHWSTLPVVRFNHADSIAPYNGMVAVTANPQVVSEEEVQDPAFRKIMEQCENVAELIGATAPIRVDIRRFSKGSPFALFDINMKPNLTGPGRPGREDRASLTALAAAALGWDYGTLLENILRTAQPFDVFRSYCSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7C3</accession>
    <name>A0A370P7C3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_80971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7C3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8539" checksum="0B56FDC94717CC9B" modified="2018-11-07" version="1">MIYLPFHVFSVRNLTESPLSMQHGPCSSTASLPKICLSCVVLFLLMLIYLTPTLATVDDPHDDDDDKDDDKITSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7I2</accession>
    <name>A0A370P7I2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_270044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7I2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="316" mass="36892" checksum="6462CE625064A967" modified="2018-11-07" version="1">MHSAYFPVGRSQRFWLRFLSNVVMVFMLVVGLIRMFSQFQSPHETQISDSQPMIRKVTMVYGNRTSYYRGLKTHEDHSLKFGYPMTVLRKPILGGYWSKPAILLSALVEEMEKPEEDQARWLFWFDGDTVLMNPNIPLDIFLPPPQFDDTHLLMTSDWNGMNNGVFFIRVNQWAIELLSATLAYPTAHPEVSLSFADQSAMDNVILEHEYFRRSIVFYPLRWFNAYPRNADAVDLNPDRPVDSQVHHGDLLVHFPGAPPDRFDEIMDPYLKVAEAHTPEWELPLQKTGYMREITDFWRDRHELLFGETPESSDNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P863</accession>
    <name>A0A370P863_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_222550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P863"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="459" mass="50990" checksum="C1701E3E734EC4A3" modified="2018-11-07" version="1">MAGFAGTALDLANQLAMKDQAKNWDKELIEITYTISASIAGIAYGPLLINPVAQAFGRTAIIFWCLVFAMACAIWSACMTSKGDYERFVASRLFDGIFGSIPSIVGVGAVYDMFFLHERGKAYAIFHVSFLFGTVAGPTFGGFIVQHTNWPWVFWWIVIAQGLVLILALFFLEETSYPRDGKMLSAVMPKGFWAKRMATVLPHKTGICRAELGRIARLPFRIGLSPVGLLIGIFQLASFGWFVATHSLLTVWLEKPVSVGGWGFSPQRNAFFIFSLWVGLLTAELWGYLCNDRIALWICRTREKGVWKPECRLHALWVPSLIILPIGLGIVGSALQYHLHYMVLALGAYLITFASMSSVPIAVTYMIECVASQPTEVGAFMGAYRLTLGLVVPFFIDQWVARVGFGWVYGMMAFFSIFAFGFVVMLMLFGDRLRERTLAKLAPSEIGAKVIYTSDEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8I6</accession>
    <name>A0A370P8I6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_307815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8I6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="315" mass="34086" checksum="E09B2B979639394A" modified="2018-11-07" version="1">MARVMISINNLRKTVRLSSTIMAVAALDQLRSLFSGTTGSIELTKALAIIRRTGTKFAVRTTGYNSNIGFSGTSDTAIVLNIKQLKSKELLADQNIAQLRSGNTRDKIYTWLEEQGLSAIGYDGSLINANSKESSNLHCSLESSGSDFAINQTTATIYQAMEEDPKIALFANFNNGFGAPPKAFKPFHSLKRLVTTVLPSTNGTILSFAHALGEVGHAQTSQKVGFAYEWPKDGSDDAAAQKAVDTISKTVQCLAKTKGTLLDFKYMTFDTGSQKVLGSYGAENIKLMQEVAAKYDPEGVFQKLQNGGFLLLDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Z3</accession>
    <name>A0A370P8Z3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_269710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Z3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF814">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="571" mass="64280" checksum="E45CBA91C165CF73" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9K2</accession>
    <name>A0A370P9K2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_278915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9K2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="54" mass="5956" checksum="30D47F9C8D1FBA01" modified="2018-11-07" version="1">MCMKVNCSNCNKATWWGCGAHIPSVLDSVPESERCTCAPKVVRDGKEYPPKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA43</accession>
    <name>A0A370PA43_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_220801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="58869" checksum="F322FB8A186AAFF0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA65</accession>
    <name>A0A370PA65_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_329230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA65"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="457" mass="49810" checksum="B9E0536171E8DA47" modified="2018-11-07" version="1">MEAVHDSPPPYATEGIDEKKEDISQVEQNLKPGLEESDAFGNEEFAEIKYKTLKWWQCGLLMICESVSLGVLSLPAAVATLGFVPAVILIVGLGILATYTGYNIGLFRERYPHIQNLADAGEILMGPFGRELFGLGQFLFCIFVMGSHLLTFRVMMNTITDHGTCSIVFSVVGMIISMVLSIPRTMKGMTWISFASFLSIFSAVMITMIGVGVEKHPGRIIEATVDTNLYTAFTAVSNIVFAYCAHVAFFGLIAEMEKPKDFKKSLFMLQAFEISLYVTAACVIYYYVGKDVQSPALSSAGPLLKKVAYGIAIPTIVGAGVVNGHIGLKYIYFRTCSKSGLIHSRSRRSVAVWIALGLACWLVAWIIAEAIPVFSDLNSLISALFASWFSYGLSGIYWLHLNYGQWFASPRKIALTVLNAAIAVFGLVLCVLGLYASGTAIHNDANSNSFTCANTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB80</accession>
    <name>A0A370PB80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="39136" checksum="50C9CC260FE3D8E8" modified="2018-11-07" version="1" fragment="single">NASLQEALSCTSCDLTSVPKDIYYDDRIKGIYDASRDPPFLTPGLTITTEDREIPPDEIPLAPKEGNGNKEEPSPTYTELLTPTQEQAYNAQLQIYLSHDATDDPKFAKYLVDYHIHIHYLLRRSMLGLCRDVRDVYELKNWMKRMHPVNHEDEVSVSATGIDITQPKLGPSQNLYSLRSKNYWKRYNRHQQSYQSPFYQPQRQYLPRSSGSSSVSSKKDDGPSDWPGDSNRQMKYQVKLWEKGAIMRKKRFEECEARWAVIQEERERQRVKMMRSERNLHRTTSARMIGGRGAVKVRLYCSTQVAGVGGDGLYYDGKRRFLREVEFEEMAFGEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB97</accession>
    <name>A0A370PB97_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_269050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB97"/>
    <dbReference type="SMR" id="A0A370PB97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480969" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="16225" checksum="9999BED4EC8FA107" modified="2018-11-07" version="1">MKFSITAAVLAFAATVVAMPGGSPSTGNGAGNGNGNDGNSQVRFPVPGDMTVKQAEDKCGDQAQLSCCNKATYAGDSTNVDSGLLAGTLSNLIGTGSGSEGLGLFQECSKLPIQIPIIGIAVQDIISKQCQQNIACCQSSPSTTDDDLIGLGLPCIALGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS1</accession>
    <name>A0A370PBS1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_328834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBS1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="37404" checksum="492FB150F1493C5B" modified="2018-11-07" version="1">MQHYISHFDGIDGLKKEDVTIPSPGPGEVLVQIRAISLNYRDMEVINGEYNHHRAIKQGSSIIPCSDMCGVVQSVGQNVAKWNVGDRVVSLFVPDHKTGKLTERALATSLGLPQQGVLATHRVFAEDALVKAPEHMSDEEACTLPIAGVTAWMAINGTRPLSQNGGRGEYILLQGTGGVSIAGLQIAKASGAKVIITSSSDEKLAKAKDLGADFGINYRNTPEWANKVMEVTNGHGADIILETGGSQTLSQSFVCAAYGGLINCIGYTSGKTQASGEQKNVNLLTLSRSLTLKGSVNGPTDRFEELIKFGERHEIHPVICKVFPFSQARDAFRYLESGSHFGKIVIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW7</accession>
    <name>A0A370PBW7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">M752DRAFT_238293</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="425" mass="49138" checksum="1E6245D051EE03CA" modified="2018-11-07" version="1">MASSPFRLSQLAIPSVCILISFLAYSSQYFFLYFEPAPLRDTELWRLNIFALCIWICYYRTCTVDPGHIPKDWKPLDSKQLEADRASGRQRWCRKCEAYKPPRAHHCRTCQRCIPKMDHHCPWTSNCVSHFTFPHFVRFLFYAVTGMSYLETLLYERASIIWASRNRPSYLGPSALQMGHLFVLLVVNSFTVFFLMILLGRTIWSMSINTTTIEEWEIERHQTLVRRSRHFGGYLTGPGGVRIRIRKQEFPYDIGIWSNIKAGMGGTANVLSWFWPLARTPDRRTGLEFEVNDFEDPDVTWPPPDPDRIPVTARVAMDDVEPRTPSIYGSAGGMPIGGPKATLRASQDIRRRKRFHDRAQEELNQSASSRESSPGYSSEPEDGEEGWKNSEGERLRDFGVEEDIEFYDEEDIPLAILMQQKAQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBZ4</accession>
    <name>A0A370PBZ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_304946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBZ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="289" mass="30392" checksum="6DE1E9FA3CFDC53C" modified="2018-11-07" version="1">MAAPSLISINKLSNSRVLIIGGTSGIGFAAARAALEHGANIIISSSKSERVSSTISHLQTLYPDNVYTDRITGRPCDLGDQAKHEQNLLSLLDYATSPLLFPNTTSSARNKDDTIERVLLNHIIYTAGTPPPRIPIASSETTASSFLALSTLRLLAPMLIGKHAKKYLVNHHTSSITFTSGLMAARPAAGLAVGGAAVGSALEGLTRGLAVELAPIRVNVVAPGAVETEIFERLGPAREAYMEAFKRGTLTGEVGRPEDVAEAYVWCMKDGFVTGQRLGSDGGALLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC40</accession>
    <name>A0A370PC40_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_278189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="12597" checksum="0D208A92E2719251" modified="2018-11-07" version="1">MSAQAYYELYRGSSLGLSLTDTLDDLINEGRIEPQLAMKILSTFDRVITEVLADKVRARLTFKGHLDTYRFCDEVWTFLIKDVTFKLDNQTTVSADKVKIVSCNSKRPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC49</accession>
    <name>A0A370PC49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="320" mass="36656" checksum="5B23B59B9C0D2DCF" modified="2018-11-07" version="1">MASRDGHMPEPFQRKVDELVRKYDRIIEPNAVLHAILQDPESLNSLVNAIQRQASLVRHRSQNPEDGEITVFDNALMILSGNGHDTQDIGALELYLAEYLGICTFSPITHAKQGLHEYDMLQNTVTGGDLCPSTFHLAFLLWTILTSFAESVSNSTNDRTTAAEQQPHSSPEQAVNTYVQGHEHPRRQQHILPPRPPPTLEEIRRREQVERLLRIYEKAKAEYNKKNPEEIDVGLARYFRDTAETTLDFLRVNDMSDHPLIPDIEFSFERAKCKAAQLAGRGRHFDQPQAAASTPNHPSKNRRRRRPRYREVDSYRPGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCT8</accession>
    <name>A0A370PCT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_338040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCT8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="593" mass="67470" checksum="3F66249550765589" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD76</accession>
    <name>A0A370PD76_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_278029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD76"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="126" mass="14176" checksum="58A4BBA520652B51" modified="2018-11-07" version="1">MGKRKKSSRQPQQPRKREPLPTTFACLFCNHENSIVVKLDKKLGLGNLSCKVCGQRFQTGINYLSAAVDVYSDWVDACDAVAKDTATKYEDSDPRVRRSNDFATSPSARDVGFEEADRNDTYADEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDY2</accession>
    <name>A0A370PDY2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_254425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="564" mass="64623" checksum="DEF4BFB73BCD258A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE54</accession>
    <name>A0A370PE54_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="26187" checksum="BA4D1B400DE205F3" modified="2018-11-07" version="1">MSSSILDTPDPASLSPFLNASSPSLRSLLHHPDYLPIRTYSRIPKPSTGEDGYFANTLATSRTIPHVLTLRRRPHLLSLLPNSPPTWPAPTGSPTPIEDPDLILILDIAAPGVSGHPSTAHGGVLATSLDEAMSYAVALYAPETGPKLVEDEQPDGPHVPPTPRGMLYTAQLDIRYKSPVAAPGYLVVRTKVLARVGRKFWVRAQAFQPQDTEGAVTSPQAEGEPMRLTTDAMAFWMQTGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEK4</accession>
    <name>A0A370PEK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_284846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016943141" description="6-methylsalicylate decarboxylase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="52"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK40619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="42508" checksum="59DE3A4CF608EEAD" modified="2018-11-07" version="1">MPPMSLTLASIILILTIFLFQPSLCGIMGEHVLDWLRDKAVGWSHTPPVNKIDTHHHFVPPFYAKANPTTAVEQQGGDPSGWPTPSWNPIASKLLMKRVGVKTAVLSVTAPGACIAPDRQSRFQLARQMNDYAADLRDKDPDHFAFFVSLPNILDTEDALAEIAYGLDTLHADGVTLFTRYGPSNTYLGHRDVEPIWAELNRRGCVVFIHPTHPVDIRPVNPKLPQPAIDYPHETTRTAMDMITSGTTLKYPNCKVILSHAGGALPYLISRVTTPMKRAPDVAVSYRIGTTHDKAMEAFRSFYFDLALSSSPQVLDMLLKMVPHDHILYGSDFPYAPITAYPAFLEELETYGMDQELRDMINFKNALRLFPRLANRTGPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFE6</accession>
    <name>A0A370PFE6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_277034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFE6"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000040">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="192"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="56624" checksum="9023B24996F3AD0F" modified="2018-11-07" version="1">MPSHSFKRIGIVGAGNMGSMMSFAFTELGLDVSIWDVKRENVDGIKKWYDEGKFSGKGKVEGFYEIDKFTKSLEGQGERKLFIFSITHGDPADSVLDMIQNDLKKGDIILDGGNENYRRTEQRQKRCKELGVSWIGMGVSGGYQSARHGPSLSPGGDPEAIELVLPLLEQYAAKDEKTGKPCVTNVGPAGSGHFVKMVHNGIEGGMLSTTAEAWALLHWGLGLNYQEISDIFEEWNTKGELRVNFLLDIGVQILRTKKTPQGDYQGEGASQNGGYVLDDVLDKVVQDDDDTEGTPYWSVMETANRHVAGPTLATAHYMRIASGNRAERLEVAKKLRIPGPKAIETKDRKDFIEKLRRAVYCSFLASFCQGLELIARASKDEGWNVDLSKCIQIWRGGCIIQSEAIADLLQPLLRPDLTNMKFLDEIASELHKHFDALKEVVLAATVADQYIPALSATLEYLKYEGGTMLPTKFMEAQMDLFGAHAYYKPGVPGEDPGPVKKGPHHYEWRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFJ1</accession>
    <name>A0A370PFJ1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_253861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFJ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016476672" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="470" mass="51988" checksum="DA7821FC68F2F346" modified="2018-11-07" version="1">MWLFLVCSILLPLGVVNAQSQYFNNKTKEFVVNGSAIPFVDFDIGESYAGYLPNTPSGISSLYFWFFPSSDPDASDEITVWLNGGPGCSSLAGIMLENGPFLWQPGTYRPVRNPYAWNNLTNMVYIDQPAGTGFSLGPSTVVSEFDVARQFMDFWRRFMKTFDLQNRKIYLTGESYAGQYIPYIASQMLDQDDDEYFRVAGIQINDPYINELPVLQDVPAVATVNQHRSLFPFNDTFMSQITKLSDDCGYTSFLDDALTFPPRSQFPSVPYNASCNIWDIINNASLALNPCFNRYHIPDACPTPWNPVGGPIVGLGPTNYFNRSDVQKAINAYPTDYFVCKDGIFPTANGLDTSPPSSLGPLPRVIEQTNNTIIAHGLMDFELLAQGTLISIQNMTWNGKQGFEREPVEPLFVPYGGSSGGGVLGTAHTERGLTFSTVFSSGHEIPEYAPGAAYRQLEFLLGRVANLSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFK4</accession>
    <name>A0A370PFK4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_236053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="550" mass="58917" checksum="742A93CD6A52213A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFK8</accession>
    <name>A0A370PFK8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_217782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="257"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="663" mass="73538" checksum="7E75BB88FFB54FF0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFV0</accession>
    <name>A0A370PFV0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_336905</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1128"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK41067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1173" mass="127586" checksum="CEE2F8B07F9B72AA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFV3</accession>
    <name>A0A370PFV3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_284563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18990" checksum="B3CFE48C4A369F23" modified="2018-11-07" version="1">MGPRYKLLEGLPRELWFHIKNLLHPADVENVLNTGPKIWNYVFKDESWLKLALTFDRCSPVLLGYNLSRLRLRGKPQKLYVALLARDYSGDLRWKKSEFFAALQDGWEYDESHYEIHFSSGLTVNVYEVLTGDDAARLPLEKIFINKKGGVYSEYCFYMDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFV8</accession>
    <name>A0A370PFV8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_217585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RDK41086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="13053" checksum="C04CF5185C4E4487" modified="2018-11-07" version="1">MAAKKRNIRRRRPSSKRSTYQQRTRRKNNLFLKAFEYCNLWEADIALVIRLKHNGQVFEFNSNSQWHPSREELVGNLYDSLKDTWYPKPREITWDELAAQYEMGEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFX6</accession>
    <name>A0A370PFX6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_236154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="956" mass="104487" checksum="690F1448C02C4280" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGD6</accession>
    <name>A0A370PGD6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_294921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGD6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35139" checksum="583D54D9C313D92F" modified="2018-11-07" version="1">MEDSISDLDTVDYDMERETESFDTEPHPNLYRHGRRYSLTRLEQHPWPIDELEKDRLEEQHVLLRELFQDRLYLAPIQSPRSVLDIRTGTGCWAMECAERYPSSTVRGIDLVNMQEEWVPPNCEFWVDNLCEPGWHTQYANIDLVHINQIQGDRQLLSLLLEGSFSCCALGGWVEICDMRVKLDNPGEDSPFHSYIREMTTAHARDGRQLDLPLHFGAELSQHGFTNVTQHTYAIPLCTAGRDELTKKIIQNWAAGLEGYSFTLLEKYLGKSFAETVLMCASARRALKGKIEGYLQIQVVYGQKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGL0</accession>
    <name>A0A370PGL0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36674" checksum="4542D94621BBB587" modified="2018-11-07" version="1">MSGNTSRSPFDVPFDELPNPKQVWIGKPGSREEGLGKLAILTPEVVANAAATEIKTGRRVTMGWELTKLDYPNLNRQPCHHQIIPLLGGVAFDDVYTMNPQQSSQWDGLRHFSQTVEGQTERVFYGGATVEEINDRTNDRIGLQHWAKEGIAGRGVLIDYATWAEKRGIRYSTFSTHQIRLSDIKEIAKEYGITFQKGDILFIRIGVTKEWDTAMTDDQKRQYSDNPSPEHAGVEATTDVLRWLWDTGFAAIAGDAISWEVYPPQSPDLFLHEYVLAGWGMPIGELFDLEALSQICQDLQRWTFFVASIPLNMPGGVSSPPNIMAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGQ6</accession>
    <name>A0A370PGQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">M752DRAFT_276861</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="RDK41369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="278" mass="30655" checksum="AD04DD4B2C148851" modified="2018-11-07" version="1">MTLITQGAEAHLYKTTYLSPTTPAALKIRPTKPYRHPILDRRLTRARVLQEARCLVRLVREGVNVPAVLAVDWDINNKNNNNGGEGDDNDVRGNGAWILMEWIEGCVVRVVIQRWERYIKSRAGSGSGVGAKRQVDGEVKEQDNEIEEEEKKVKGLLRRIGAAVGALHKAGVVHGDLTTSNLILRGADEGGDGDGASPDMQGEVVLIDFGLASQSIQDEDRAVDLYVLERAFGSTHPRTEPLFGEVLEGYRASYRGSGSVLKRLEDVRMRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHD4</accession>
    <name>A0A370PHD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_302061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="490" mass="53850" checksum="EF87E7BDC293BEAE" modified="2018-11-07" version="1">MTRTNSDEVNGGGSTFRSNVIKDGVLRYPPTSVKVVIVGGGISGLFAALECWRKGHDVQVVERGANISEAGDVVGIGPSAWVSLQKYPSMIEEWDRISDDPVWLFCGEDGRPVAPPSEYEHNSNGVAQHVCYPLRIKPLIVRSQLAEMLAGQCKRLGIPIHFNTPIVDYEEDGPSKRATAITTNGQRFSGDVVIAADGIGTKSHKIVLGEEVRAISTGFIIYRLKCPVSRLANAPAFQQLYQQMGRPEIRLGPAGQLHYALTMAKDYVSLGLSVKDDGTATESWSATVSSDYVLSEHPEFIDCQPVIADIIRNAPDNSIVRWPLVMRNPQPKWTSPCGRIVQIGDSAHSFLPTSGNGATMAIEDALSIAECLRLGAGDVGTATQVHQLLRYQRASVVQQTGMNNRSEINNKMSNDVLRQGKWIWTHNPEQYATTEFYRARSCLESGAEFHNTNLPPGYVWTPWTIEEEMAKEKAGVHSQDLKKNGYWGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHQ6</accession>
    <name>A0A370PHQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_319774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11284" checksum="0F5C2574F4A33F1B" modified="2018-11-07" version="1">MTERKSTVPGVRNVARRRETIFRKCHELSKFGVGVWVVICTGARDTMFKSSNTPLFEQLDRQMIRASRRPVWKYSSDYDRLLRGDRPLRLIDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIU3</accession>
    <name>A0A370PIU3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_252525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="561"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117218" checksum="395FE8408CD559F3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIX1</accession>
    <name>A0A370PIX1_ASPPH</name>
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        <submittedName>
            <fullName evidence="7">Choline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_294112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="76"/>
        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="350"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="523"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="544" mass="59273" checksum="239B01B4DC348BDD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ29</accession>
    <name>A0A370PJ29_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_336509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ29"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="5">
        <location>
            <begin position="249"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="47725" checksum="84C0E618E3DDEEDA" modified="2018-11-07" version="1">MDIVASLYPALSERKPLPTYYTPVCLGLSLVPFLVENEGFSAFSTWPFLLYLCASWPCFTTGDPSSDYYNNSHFIAFPLWYLDFVFLTPRDGKDAPAFIGRQLTDEERGDEGGVITVQRQRWKDLTTFSQRVKWAFRLMLPVHRGIGWNWQVKGVPADPYAKLPRWQYVGWQMWWVVFYYVQSMGALAGLGLGCALRAQIRSDELLKTVVANAIVGWSGAVWVWDRLNCAYRLAAALGVATGATETWEWPPLMGPLKDAWSVRQMWGATYHQVCRRLLSQPSKRLVRFLRLCKGGLASSYSQLFISFGISCLFHQAQMFNVTRRDMGELAFFMSQPLAIVVEDLVRWVWKKTGLSGKSIYFEKVVGYSWTLVWFSTSLHLYISGLVQARVIKDWLFGHRPLEIGADAGQQLLMWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJA0</accession>
    <name>A0A370PJA0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_234258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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            <end position="76"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="275"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        </location>
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        <location>
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            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        </location>
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            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="532" mass="58885" checksum="6DE028E793F3B7BD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJB0</accession>
    <name>A0A370PJB0_ASPPH</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="6" type="ORF">M752DRAFT_251394</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="436" mass="48694" checksum="A424B65E86C70E04" modified="2018-11-07" version="1">MVYRGKPGLGCALCRTRRLICDRRRPSCTQCLRINQECSGYRDPNVLRICDQTDETRVQGLLSYLPHLLSTNPSPALQATIKAAGLESMARINRRPELKRAAGEEYGRALIATNNALRDPVSAKSDSTLGAVILLGMYEWNACSGLMQGWSQHVRGATKLVELRGMEQLNSETGLELFTLVRLQNAISGVFKRSRRYKSAKITALTKLAQAKKDRNSQPIEVFYDILMELHDLSVEVDDAAVVDDSIGTLSILISKALHLDTDLRAWAMSLGPHWQYSVVDTHSNPKSRPHIPLHSDTYHMYKAVGVVSMWNHYRQTRIILHEMIRSMGLRLWGLQGTSECQQIVFDSIDTIKQMTDDLCASVPYHFVSGEVTFPAVIRLLWPLFVAGDCAGAEPATKEWIIQTLELIGNTTGIQQGLGLAHMLRNGHTRNFIPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJN1</accession>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_215127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="78525" checksum="9861DB8D7503C3EA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJN8</accession>
    <name>A0A370PJN8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT DNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_319554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55741" checksum="DFFDA9A65487B5CE" modified="2018-11-07" version="1">MSDSDTALVPWETVNDELFGSQCDSTAPQITSLLSACSYPVPQQIRRQRNAQFPLLGGIIPENQLLLYNNDTQPAEPAVKSLKRTRSDVDKRGSTSLTKRGRPRKVVDDTADEDPEERRRRQIRLAQRAYRSRKEANLSSLKGRISELEGIVEKMSTAVLSLSDELVQSGVLASHAGLTEQLRDTVQTCLTLAREASNDSPQEVTMISPPQTEDGLPDFLAHEQRGQSAQIVELDESVSSILEPSLQLELRETRNRNIPRFFESLETAEMDLTVFTDRLHMSCVYQGCFALCDESISIDRIRKHFCLLLQIMDRKRIASYFQAALNEKESRRYFEEWEEVPFFSLGGAGTHYSRSSLKCKAADRPFRPGVRWVSVRSLSHFPQDIQTKLEGDWFDMGDLEGYLREHDVHLLAYPPMDHARHRLKGTAINAARFIQALSANAICLGWTPGFRRRDVENALQTCSDFSYTSEDASGSPGISFAGFSERLARQTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKA5</accession>
    <name>A0A370PKA5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_251835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKA5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="192" mass="21805" checksum="83D08A059D97B2F0" modified="2018-11-07" version="1">MSSATKASRIGEELWKTRVDKVNAELVTLTYGTIVAQLCQDYDGNYQEVNKQLEKMGYNIGMRLIEDFLAKSGVGRCANFRETADMIAKVGFRIFLNIAPTVTNWTSDNNQFSLIFEENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMQIEAHFVSDVLRGDDTTEMRVSLVRYIEDEMPPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKS3</accession>
    <name>A0A370PKS3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_275909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKS3"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="38058" checksum="2CDB3D8C10C8040F" modified="2018-11-07" version="1">MAVSSRQQHTFQVFRDVPPLRQLRRELLLSKRTVGLVPTMGALHEGHLSLIRQAAAENTDVFVSIYVNPTQFGVTEDLSSYPRTWDSDVAKLEELNAELARQNSNSGRITAILAPTSKVMYPTLPPSSEIDGDGSFVTITPLSRKLEGASRPVFFRGVATVCMKLFNIVHADRAYFGQKDVQQTVVIKRLVKDFYIDTEIKIGETVREHDGLAMSSRNVYLGKRRRAVGLVLYEAMKAAENAYNAGKVNRSEILDAANSVTERVLSEQKALAPTERALYEVDYISLADPDTLDELEVVDPAKGAILSGAVKMAPLEEAKPGEDCGLGDGQVPVRLIDNLIFKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKT2</accession>
    <name>A0A370PKT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_335538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20436" checksum="F039A6D012B384DA" modified="2018-11-07" version="1">MLRNTKLLSTRSHPFLPAITTGPGQLCHPSVSSYQHRCLVTSQTIHKERHLESDLDRHLLRPEHNENTKSGTDDEAAHHWSSYDPTITDPDLEVLACEEECELDGDLDDPLFVSPGNREVSRFLDPMVGGAVHGATRPGPSGRGWTRKHKEVIIKKIPGSQFERYDRILQELRKADKQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL30</accession>
    <name>A0A370PL30_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_233792</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL30"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="600" mass="67705" checksum="A16885F889980822" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL37</accession>
    <name>A0A370PL37_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_163666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL37"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="116" mass="13341" checksum="7A932AE781CE8357" modified="2018-11-07" version="1">MKKYTQHNLNRKRKKKVKGGKKKHLASRGILMILLPLLSFRAVSPTRFDRRGTIRNPPNQVAMPPGNDGRLGRTFLRCRQRVVWNISSSFCSQYCFGGVDRLGVERKRILTRLSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLE4</accession>
    <name>A0A370PLE4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_265869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLE4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="95"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="478" mass="52573" checksum="7118404B5E5721D5" modified="2018-11-07" version="1">MTPTAWLLAKLKSAVVLTYGLGGLLFYGLVAVKLGYFFKQTTEKEELELKIARNKFWDLSKKWDGFSHHILTLRNGFKFHYVCNDQGASLDQDKPVVVFIHGFPDSWAIWRDILSSSSLQQSATLIAVDMPGYGGTDSLNAYSPTNVLESLTEFILAIRAKYGVDTEAGMRQKKLVVVAHDWGCVVSMRLAAEAPQLADRFILSNGPLPRLASSNISRLLSASGKMLKTASRSPIQSRSMIFKAFATLSPIFRQFRKSKYIFAMQLPMPLVRYFGRGGNYSFLKLIHRGSFGKREYTPQDAAECFASSLGPSVAESRTQTADGEQYPESLKNERAPSSFQHMACYYRDGTAFVRWDKSVETISALHSIASSSGGRRASSGAGLFDDGPKGALKACATVIWGKGDIALEPQICLDGLADYLVADSQLVELPLSGHFTPLEQESQVALEKAVEWAVKGEKEDIGAVIKACYPTAVVTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLR4</accession>
    <name>A0A370PLR4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55082" checksum="24DEADD9261D18E2" modified="2018-11-07" version="1">MLKPAQFLDTRRRDSFETMAESSPSSRQPPSPWTTNSSTPVSPAVSLFSAKGHTRFSSSVSSLVSSPGHGNSMESSSRNPLTGVKEEPCGSQPRDLEEDYFQHFDQGLSVAEDSYYASFDASDSYDLTDAGMDLTHSPRNRRSDSISARGLSRIGSRISTISTRWKSKRASDGLDGADVFATQLRSRTNSASSAIASPTTGSFTRVNSMQVPPSPARTIFEEAISEAGTQPIDISKANRYSQEEDSAPQATTPLLPPFMGDEPSYQTASRVHSPLQSPSVADNMVDDGPVVCSAVADLRLADLPSPPLSSKPSVSSFNRPRASTVRTVSGDAPPFTLSDPNDEWANRLGHANFTIQPEPYVPETCDLGAFGQLRADWDLAQCNFMRHLVRTGEHYGVTSTIYKLTEEKWESINREWRRHHEAMLSELEVTEGPRLSLMKFHCDPCDPVKIPRLHDDKFPELGDGEIVGPMKIAPAANGSGLCRTRSLKRNFVKFFQDLVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT2</accession>
    <name>A0A370PLT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_153077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="936" mass="105407" checksum="5C2BC400936512BE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM22</accession>
    <name>A0A370PM22_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_213540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="619" mass="68550" checksum="FB914CC267AE8267" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN94</accession>
    <name>A0A370PN94_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_292809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN94"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="77" mass="8096" checksum="31B69B840443C42C" modified="2018-11-07" version="1">MSLNEVWQAASASPYTPPVSKDNQFLVGFSLLLAAFILTGLFGLNRSFLSIASFGVPASLAFGFGAVFMICAVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNI1</accession>
    <name>A0A370PNI1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipo protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_334628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNI1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="81586" checksum="21FDC8EE0DAEDF00" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPP9</accession>
    <name>A0A370PPP9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_292303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPP9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="37699" checksum="368AED9D51EF3787" modified="2018-11-07" version="1">MAISYEGMGLAAHQFSGQKLPLLQAAVEWFGVCGEVLGEVQDDWDGGGGVLVCEDEDDPFVEYPHHYHDCDEEDGGGGGREWGEDEEGMLFSGESDSSFDYTNTTVSAYSEVSLFDRAEEDNGYGDERGLVPSPLKVRKVSGESVGSGALGISEVEDYAMDAAKAGVGVSVPALPLPLPLRIAAPATPTPEYTGHKEELGIRTMQLVKRPEYENKLQINTTIDFLRHQVTSSVTTLHKMITDVAEMQHARRMSKGMRRSGSFWSFSPVKEKQVSGGDGDGDGDEKEKSSFGVKESKEQRIARLRRDGWQTVGIRGQKSGWKGEGYYREYCERVLDELYLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ55</accession>
    <name>A0A370PQ55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_274699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="49896" checksum="A3C68F9858A9FBEF" modified="2018-11-07" version="1">MTEDQDLMAKISQLAGQINRHKTQQSQPESPYSSEIAPGHHVSRHVPYRGRGWAPYRGRHYARGRHVAPHRHRTLILNNATSGTPGSATPAGTGTDTDGEARSATPNEWVVKRDRHMQLINTSIYDKETQARTKAMEESRQAKAQKRAQVEQARVLNYAQGVGRVHPTGFAAPQVSTADPSAEYQVFVNDIPFRVSRGGGKLIRVSDNPNTANATPKRVTVAGVAFVRSKNGNLHRLGAVTSKRKPMTVKKKNALCQRFTTTGSCYKGPTCPYIHDPNKVAMCKDFLQTGQCNAGISCDLSHEPSPHRSPACVHFLRGRCSNPECRYAHVRVTPGAPVCRDFAVLGYCEKGAECDQRHVHECPDYANEGVCNKKRCRLPHVDRAGQIRKNAASKTDATAQAEESDASSEEEEYDEIDTDDVDSDDLDEDEPQLIAAESDTGEVSQQQDYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW0</accession>
    <name>A0A370PQW0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_248697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQW0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="799" mass="89537" checksum="730CEF7D2E3D2EEC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR16</accession>
    <name>A0A370PR16_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_274946</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000005">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="13"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="360" mass="40539" checksum="6E8C927F474D41E3" modified="2018-11-07" version="1">MAPSDPVSRTEPSTDRNVKHVVLGDLLFPTWYQSIYPEDLVNKDTDRLYVCRWCFRYSCDVHAYAQHTRLCQHRITPPGTKVYDHGGYSVWELDGESHKLYAQNLSLFAKLFLDHKSVFYDVVSFLYYLLVFTDPNDPENYYVLGFFSKEKLSWDANNLACILVFPPYQHKQLGKLLMGVSYKISSWESDSGLIGGPERPLSEMGHRSYTRFWQERIARYLLLKGGKPKEADASGSVPLKQKSPKTSKRKHTHELMTVQDIGLATGMLPEDVVTALQGLGAVEPATPAKKRRTKDSSGEAGSGADEALLIRKSKILEWAKSHHMALQDPVRDEGFLGKWAAVDSTEASDVDSDDVDEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR83</accession>
    <name>A0A370PR83_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_274028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="27391" checksum="5D20709582CDB71B" modified="2018-11-07" version="1">MAEPAAATPAASTAPAPATTTTSTAGPTSTTTTNSTAPNPTPNNSNANNNSNNTTSTSTSNPNPNQSADSSASSTANRGLPYYEKLRRELRDTLQKKRLMDKSMAQLEDQIYRFEQSYLEETTAGNIIKGFDNYIKGSSSGAGIGGAGIALSSSMSGGGGAARRKATVSDADRVFSRSSASFMRDSPAPSSAQTTPSHAATPNSTYNGSTGKPGNGDASSAANSVKGGQASKNKKKSAASNKDKGDDDGTDGDRPPTKRLKITYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRC4</accession>
    <name>A0A370PRC4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_274045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRC4"/>
    <dbReference type="SMR" id="A0A370PRC4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="497" mass="54027" checksum="19D84C6C1A275110" modified="2018-11-07" version="1">MTSKIAQSLKQPALDFLSFVNASPTPFHAVQSAKELLAKAGFQEIKEKDSWASTCRPGGKYYLTRNQSTIIAFAVGKKWKPGNPISMIGAHTDSPVLRVKPVSNKRGEGYVQVGVETYGGGIWHTWFDRDLGVAGRAMVRNGDGSIVQKLIKIDRPILRIPTLAIHLDRQETFAFNKETQLFPIAGLVAAELNRTGASEETDKAAKEANEDKGDLSPLKAITERHHPYLVELIAAEAGVKPLDVLDFEMILFDTQKSNLGGLLEEFIFSPRLDNLNSSFCATVGLIDSVADSSALDEEPAIRLIALFDHEEIGSRTAQGADSNILPSVIRRLSVLPSTAGDSDDIATAYEQTLSTSFLVSADMAHGVHPNYTAKYENDHRPQINKGPVIKINANARYATNSPGIVLLQEVARKAGEDVGEKVPLQLFVVRNDSSCGSTIGPMLSAALGARTLDLGNPQLSMHSIRETGGTFDVAHSIRLFTGFFKHYANLSKTIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRH4</accession>
    <name>A0A370PRH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_263634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="16152" checksum="7F232E1ADF02DD5A" modified="2018-11-07" version="1">MPYRTNYEPYTSQSFEMKRELSTEEILYPLGTLYPHVVALQLQTDEYPWCKANHYAGYDSSLSVDEASEHYSTKSMLRRNSGMCTCPSSVASDFKSNQSDLSDKVHMSHANVCADSTACRIVSRIRRLLNRDELRRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRQ1</accession>
    <name>A0A370PRQ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_324864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRQ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="193" mass="22189" checksum="0CEDF7C27068F1E9" modified="2018-11-07" version="1">MAPVPRVYSKTYKVPRRPFESARLDSELKIVGEYGLRNKREVWRVQLTLSKIRRAARELLTLDEKDPKRLFEGNALIRRLVRIGVLDESRMKLDYVLALRVEDFLERRLQTCVYKLGLAKSIHHARVLIKQRHIRVGKQIVNVPSYMVRLDSQKHIDFALTSPYGGGRPGRVQRKKAAAAAGGGDDEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS55</accession>
    <name>A0A370PS55_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_263604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="247" mass="27017" checksum="59F7A6FB86EC33B2" modified="2018-11-07" version="1">MSMASQSDFFSAMTNRSLRNVRSELEFLADASVITPQQLSSILSQLPRDDERSRAPVPQQQPPVQQPPVVAQQPPAPYSPPTNQFANTTLNEKATYQQPPPQQYSTPPVPPPAYPQAPPVLSIASALYAYTPTDPGDLALQPHDRIQVLEHMNADWWRGRNERTNLEGIFPRSYVNVLNEKAVSSPPPTNYGNMPLEVSQSGSTPPGEEGKKSKFEEQGKKFGKKMGNAAIFGAGATMGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSF3</accession>
    <name>A0A370PSF3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="254" mass="28476" checksum="4C5115E0C75D86F3" modified="2018-11-07" version="1">MAPIRRYLRISKYTVLECRIYLENPSDIRWLLNARDAVLPRVFAAIRPLVLPKLREENERLFAKKKGKPVKDVISEEEFDVALFLRESRTRHSLLTRHKEFDEDEGGYAVGRGSGSGPGGAGAGAGILIESDDEGEGLEMRDIPQATSDDDGAGAKRQRDDADGQSDDSPERQRTSKRRKDDGTLSRDADDGDDKKMRFRTNYEGFNIYGWVLCLLVTRKGDKTGTRAATGEPGRQVLMEEWISTQAQGDLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSK8</accession>
    <name>A0A370PSK8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_133322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="297" mass="31917" checksum="9F94DF4CDCC72E5E" modified="2018-11-07" version="1">MASAIGKEGVFQPPQAAQSQNKPGLEKKMAPASEATKLESSGTFVEYVGSGKLKDKKALITGGDSGIGRSVAVLMAREGADVTIVYLPEEEEDAQDTKKMVEAEGKSCHLFSGDLRSRETCRKAVEEHMNTYKKLNILVNNASKQYMCKDFAQIDLDNVTSTFESNIIQMFAITKFALPHLSKGDSIINTTSTVAFRGTSGMVDYSATKGAIVSFTRSLAAQLKPKGIRVNAVAPGPVYTPIQVDTREPEQMENWGAGSSIGRPGQPSEVATSFIFLASADAALFYGQVLHCYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT49</accession>
    <name>A0A370PT49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="706" mass="78734" checksum="E61F1D6A94EF858E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT83</accession>
    <name>A0A370PT83_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016571070" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="156" mass="16960" checksum="DFFAF8D1C105A4C1" modified="2018-11-07" version="1">MSPTQSLGKLLVLILISSSSAMSLARYTAPIPQGAKVVETREQLNQVVRENPETVLYDQDGGYILKDESGTVVAIAADSLCPELDQALAEVEALQAETKLAGNAGEQSDTTSKKRDVNDVQDTNRPLRCSHPRCFNSAICLTYTDCHVCLRSHHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUG9</accession>
    <name>A0A370PUG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_247001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="303" mass="32911" checksum="B5BDA81ED4F9D20B" modified="2018-11-07" version="1">MSLSIDAYTPTEVINLVARAGIAKGNTRLDKVFLSSVSAGCLLALACGTALSTNTSTWFQENAPGLIRTISALVFPYGLCMIILTGADLCTGSFMFTTVAALQRQLPWWKMLLHWFITFWGNLCGSLFVVAIIFGYGEVFSTDPYKSEVISFATKKQVTPHFQQIFLRGIGCNWLVCLACFFGLQGRDLASKIMGIWWPIFAFVSLGFDHVVANMTFIPLAIWLDAPDITVGLYVWKGIIPTLLGNIIGGGLFVGTYYWYMYLLQGESITLAGLRRQGMATSATATPATAGGKDDVEATAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUJ0</accession>
    <name>A0A370PUJ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="264" mass="29135" checksum="B11268AB308A9745" modified="2018-11-07" version="1">MSTSKPVILLIPGGWHTPNSYDKLTNLLKSSGHEVHVPALHSMNGARPPTADLETDTAVFREYTQNLADAGKNIIVITHSYSGQVATNGLSDLAITNRSKQGLPGGVVHLVSLSAFTITEGRSMFDIVDQFGHASLMPMAFDFAEDGTCVDRDPKGLLVTPGPEEADSEVDWYLGTLQRWNGKCMYQPITANRAAWRDIPVTYVLSTRDMTVPVDYQRWMVDMMRKEGAEVEDFELDSGHSVDFSRAKEVTEIVNNVVARYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUM9</accession>
    <name>A0A370PUM9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_124888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="261" mass="28144" checksum="F30FE95A8220792D" modified="2018-11-07" version="1">MADAVEQSPTIDAQKNVPSSSNPDRVRKPPKLQRRGGPSDASKSVDPAPEPEQPSAEAAKAGEAAVAEAPEETETMDPSPDTEETQIDRDTRSTSWSEGEQPQLQPEQQPLQRQRSVISVTESVSSPSSSTPASADAYYRQTRRRGQRGDMRRQQREQQQALALPALGNVGDVPGNLTQGVGDLAQNTAGRAVGTLGNTAGKALGRSIMGGRNDTQVQQQGQQEVGKKKDEQLRLRLDLNLDVEVQLKAKIHGDLTLQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVF2</accession>
    <name>A0A370PVF2_ASPPH</name>
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        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">M752DRAFT_323937</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
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    </dbReference>
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        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RANBP2_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
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        </location>
    </feature>
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            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="417" mass="46789" checksum="9C98086881C4BD65" modified="2018-11-07" version="1">MREIDPLVFEYQHEKQRPREAEALLILRKVASLVKPIMRRRDWKVGTLCEFYPHQRNLLGLNVNAGQKICLRLRYPSDQRQFLPIEQVVDTMLHELCHIVHGPHNQQFHALWNQLRDEHEELVMKGYTGEGFLSEGRRLGGRKMPVDEARRVARAAAEQRQSLSAGSGRRLGGAPVLRGTNMRRVIADAAQRRIEVTNGCASGADNSAELAEEASRNGFRTKAEEDDANERAIMEAYIDLIEQEERERYGPSYIPPSHDNPAGPRTTLSPPPVLESSRPRGPSQPADTIDLVSDDNLYDKPWSCPTCTLENPANFLCCDACASERPRPTTTRSVSGPPTTTASSIQPNPAVSKNKRSISPSTRYTGFKNRTRAVESLAALERNANKRPLGWLCDNCGAFMETEWWTCSNCGLMKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVU3</accession>
    <name>A0A370PVU3_ASPPH</name>
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        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_229021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVU3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:establishment of meiotic spindle localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="627"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="988" mass="110459" checksum="1DC1CF041F1B6AC2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVZ7</accession>
    <name>A0A370PVZ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_332972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1702" mass="189462" checksum="EDBB414037A2E921" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWJ4</accession>
    <name>A0A370PWJ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_103914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWJ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="142" mass="16105" checksum="F58B32514F2352E0" modified="2018-11-07" version="1">MSDREFSANDDLSLPKATVQKIITEILPPSSGQTFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVERALRDLGFSDYIPDVLAVAEEHKEQLKSREKKQSKMEQSGLSEEELLRQQQELFRSATEKYHAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX15</accession>
    <name>A0A370PX15_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="604" mass="69467" checksum="5E3BF1F6376268A8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX64</accession>
    <name>A0A370PX64_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_244799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="111"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="551" mass="60449" checksum="38AD5858D596EE80" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXK4</accession>
    <name>A0A370PXK4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_227831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXK4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="552"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="653" mass="71142" checksum="74131CA909EE9360" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXL8</accession>
    <name>A0A370PXL8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">M752DRAFT_332223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXL8"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="36612" checksum="8789F358BF7AB74A" modified="2018-11-07" version="1">MLRPTSTSTTTTLLRTLRTLTTITTKRHHSSVSANELSHFSSLATSWWDPQGPSRVLHLMNPVRHDFIASCLAESTPISSTTPSSPMDASNTHNKNNLRYLDIGCGGGIFAESLARTIPASSSSSEGTLTRTRAASITALDPSPTLIKIARDHARLDPSVQAHLDSGRFKYVNASLEEFIPTLQTEERRFDIVTLFEVLEHIDNIPGSITPQSFLSNCLSMVKPGGWLIGSTIARTFPSWLVNQVVAEAPWPIGVVPKGTHEWKKFVNPGELEGWVQEGLMRGLDGRAARGGSEALEGAKWRCEGVVYFPGLGWKLVKGSESWGNYFWAVRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXQ0</accession>
    <name>A0A370PXQ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_207591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXQ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="556" mass="60967" checksum="B2459ADCD64ECD3C" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXR0</accession>
    <name>A0A370PXR0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXR0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="137" mass="14906" checksum="21562B4947961C24" modified="2018-11-07" version="1">MDLVNGNIDKEVRQGETQKAELRKSVAKTGVDGLSSSDQREMDMDVQLFGQTSSSDYHSPSSLLDAMEQAISDIDRQVSETDEEATAILAMLNNTVGEMSDLRYGKMQGPAGTSGEDMVNEAIRGLGHLENACYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXR5</accession>
    <name>A0A370PXR5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_272752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXR5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="212" mass="24690" checksum="CAF4C0C82B4205A1" modified="2018-11-07" version="1">MAGLQTRSTMSLPFSLSAAFRNLSVTTPKRSFSTTLAAQKTKQLPDYIPPYPYGPNYVFKQSNSGLYGGAMIQFGNKISQGRNEGKTRRFWKPNVRRKKLYSEALGEDLFIKVTRKALRTIRKAGGLDNYLLSDRPGRIREMGIFGWELRWKIMQTPKIQERFREERKKLGLPEPPTFEEWVKQKEDEIKAKVEEETNIKEITKPTYNEKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYJ3</accession>
    <name>A0A370PYJ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="152" mass="16707" checksum="960C7DE3EBFECC7E" modified="2018-11-07" version="1">MSLPSQRKFNLNANKANPAVSGGLRRSNAQHRKREDLVPLMFDPAQALTFDQSSNSWKKQEFRQDPLNQLTIRPGAETTRNKDKGKRPANMNAWSTKSGGVCSTTTITTSKSSSLNPASASSSAQLAGPTRERGKIETDPSKVRWPLIGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYK5</accession>
    <name>A0A370PYK5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_273007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYK5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="140"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="628"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK47282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1249" mass="137742" checksum="5A378303429DFD44" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ38</accession>
    <name>A0A370PZ38_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_1115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ38"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="64565" checksum="4A0B09ADE5B062BA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZL0</accession>
    <name>A0A370PZL0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_3245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="13180" checksum="4274D8567C650246" modified="2018-11-07" version="1">MPSFTLGNAVLTAFEASSVKLTGGATAGTGAVVSVTVASGTAVTAGPVSAAAASLPPLATISGTVVSGAVVTPRSAPALTSLSSLVAVSGTTVSGTVVSVTPVSVATASISLSLLGTVSSTSLAGTLFRREKCQCHCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZQ2</accession>
    <name>A0A370PZQ2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_299567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZQ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000285">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="57699" checksum="20A732F3CF8CABA0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q005</accession>
    <name>A0A370Q005_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q005"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34136" checksum="6A385C9BE7B80911" modified="2018-11-07" version="1">MNNHALLIRRIQPLRSLRRQPPRRHLSSTPHNAEPHHNPVPEKHHTPSNNPQPAPTVPGPVASTTAAPGSVSASRALIQRIQAGPVGRVARAYARVQERRPYRTQVISTIVVYLCGDLGAQLLFPPDNGSPQDVQAGDQKQEAGNNAGGIGGGYDPWRTVRHLTVGVGSAIPTYKWFMFLHNNFNFSSKFLSILTKVCVQQAVFTPVFNTYFFGLQSLMTGKSLEETFERLKVALPTSISNSVKLWPAVTAFSFMYVAPQFRSIFSGVIAVGWQTYLSWLNQKAARKVEAERLASVEVGAGADAGVGAVAMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q087</accession>
    <name>A0A370Q087_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q087"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="311" mass="34470" checksum="EBF7548138F9CDAB" modified="2018-11-07" version="1">MAQPCHPAELPMSHSANAQYTATQEYSSGKSHLQPSVYTWSTLEDVNSHHCDSDNPAVHQFPEGEFVPSGFFDKVNISLFKNTNSPGGDWRYEKRRQVHQILPFLHLGPWSCLADRGWLNQEGFTLLLGIRHSRLAKAGLLSGSKAAAALDIMTTSVDYRDNQELIGMLPSVIRCINEHIASSAPLGLSQSTEKKVLVFCETGNHSSAVVVMAYLMVMLNISPMKAMDLVQSQRLSIIVDEPASQLLLAFEAIIMAKRDVERVRRASILDTSSSSKKRTNSQDTDDMDIDEIGTLDPERKPLAPFQDRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q129</accession>
    <name>A0A370Q129_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_244319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="280"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="623"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="919"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1477" mass="162809" checksum="7D614F01578080F6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1E2</accession>
    <name>A0A370Q1E2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_12552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="102" mass="11604" checksum="F53F97ED30D8F677" modified="2018-11-07" version="1">MLAWDWLSRFIIVIISIHCLILGGTFLVESSVFTCLCLGFLASCLGLHIPRCSFAHNGEQGRNTTYLASFGFLPFYIDTLFPLSRFPSFHFAIESLISFWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1G3</accession>
    <name>A0A370Q1G3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_8160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="241" mass="26748" checksum="5B36380C57AD7F33" modified="2018-11-07" version="1">MPSTTKRLGADPSSTTTTTTAARDLDRREHSPTDDDHLQHTATSTTGREEDEDDDDDYTSSSGSSDSDSDSDDDEEEEEEEQVNQKETTKSESTPATTTSDDIPRIRAIPKPRIHRINKNPDLLSRLSAFLPQMKSANEKLEQEIAAGRGKDVRLELDGDDDDEDMEGKRYIEMNLGLGVLEEKRPGDDDEEDNVESKGDQNNQHVLPERPKSGKDSNVLDTLMGNADSSAEKEKPTIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1L8</accession>
    <name>A0A370Q1L8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_300152</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1L8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="502"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK48339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="711" mass="77857" checksum="29C96CFECC47E048" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4F9</accession>
    <name>A0A370P4F9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_280105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4F9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="232" mass="25947" checksum="7B8F689586CA67C7" modified="2018-11-07" version="1">MLPLTGRAIPGAIPNALHVRPRITSCQFRIQPVSFLSTSSVKSATAIEQRGQSGQALTASGKVRKEVPLPSQEKKEGAMQYVLTTLDQVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQKKMRHTRITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4G1</accession>
    <name>A0A370P4G1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_287527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4G1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30751" checksum="E14F3AB2AA738604" modified="2018-11-07" version="1">MSPTRTVIGHSSPLLTRELGFTRQSAFPNMCPVNACSPALFKYNNVYFSMRIIELFDSHCYHKNRAAKDVPLKVSHSLPDIVHRKGIMARDIVKAAKSASNVIAVHKKYTVQSTGIWERIRRLLAVDPNRSTGVPLNAQYRLPTPGALPPLSYDDPVTVPAGDLADNPYWKRDTRRNYPRLSAVSQADAVGLLSVGSQAAPKDDVLQIGEAGEKQLVSVKQQAEERGLAGLFEKDKNGIKEVLGANGLPPLPCNLNPTGGKYQLGHDHGYPNIYPCRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4J0</accession>
    <name>A0A370P4J0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_322187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4J0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="171"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="36369" checksum="169F5D6B90DF35AD" modified="2018-11-07" version="1">MKLQQCLPSNNPRVWQRLSSVALRFSSSNQPRQQRCFTSTTSRSYRPLDSLNDADINDFRQNYFTPERPTILPRGSFPDFPAFERWFEPAPTEPNVSQLNTTYLAQHGADAFVPLELTQLASDGAAGTGADGLTFQQFHAPLSLFLDWIRTAETLETQSARLYLAQCQLLDLPQVLRDDFPTPELVAQAGKGDVYDTNVWIGYPPTYTPLHRDPNPNLFVQLAGQKVVRLLSPGDGQKVFGSVRRQLGRSGGREAAAIRGDEMMQGQERALLEQAVWDEEKAVPGLDGYEAHLEAGDGMFIPRGWWHSIKGVGTGVTASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4S6</accession>
    <name>A0A370P4S6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_280137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4S6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016705762" description="Fungal specific transcription factor" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20318" checksum="E1743AB0AD205532" modified="2018-11-07" version="1">MYMSSTLTRASLINLLLTTTARIAPASATATLTTTTYTPRHFLHQATLPLHPHCSAIHLYNNAITTTTNRYQKEQSSHYSTMSTPNDQQTQTQTQNQQEGDDQQKPILALPDAESATKLDVSGDGSAVALDHLGPVVVNQDGTLSRISNWEAMTEIEKKNTLRVLGKRNKMRLEALKKERGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4T9</accession>
    <name>A0A370P4T9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_225241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4T9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="56628" checksum="FC0DF99B92E3DE12" modified="2018-11-07" version="1">MPGRLLSSFVRPSLSHHHSHHSPVSHSNSSSSSSVNEIPPNTVVSKKPSAHGAERARSPERRLSFAVEHLIHPHRDHSKDKRRSHGRSSRSKERAGQEEIAHAHAKLDVIVESPPLVCYGSPANSTGALFSGRLKISISELAGMVTLDTFDMRLMSRLTTKKPVSRDCANCASRTEELTHWNFLTEPIHLKNGDHEFPFSYLFPGHLPASCNGSLGQVEYFLSARAHNINGEEYTYEMPVHIKRAILPGNDKSSIRIFPPTNLTGRIVLPSVVHPIGTFPVQMTLSGIVDKKEDTQTRWRLRKMMWRIEEHQKIVSTACTKHAHKIGGEGKGVLHQETRIIGHNEEKEGWKTDFDTAGGEISMQFEANINPSCNPVCDLETPGGLEARHNLVIELIVAEEFCPNRNPKLITPTGAARVLRMQFHLHVTERSGLGISWDEEMPPVYEDVPASPPGYTMLDGDSIMEDYHGSPIHLPEYEQLERMDSLRLDSDSTHSSIRGRFSSTGPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P587</accession>
    <name>A0A370P587_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_340027</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P587"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12042" checksum="5EE02D1400278738" modified="2018-11-07" version="1">MSTTPIPKNRSSSPTVFEQQRAELVREIAVGMEQVLQNINRLNRNLESIISVGNEFGSVEALWSQFENFMGRPGEENEAGDGGKQKAGAGGSGGGHHQDEEQSQLQEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5W5</accession>
    <name>A0A370P5W5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_224526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5W5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="114" mass="13068" checksum="BDD5D2ABA1D84AC6" modified="2018-11-07" version="1">MSIENLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVNDTEMGEVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P798</accession>
    <name>A0A370P798_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_330370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P798"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000469">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="432" mass="48165" checksum="6938C24A90D612E7" modified="2018-11-07" version="1">MSTQVLIVGGGIGGLTLAAMCRRIGVSCRVLERSAALEPVGAGISLAPNALRALDQIGLYDYVRQEGQPVRKIRVYRNQTQWSEIDFQWLERTFGYPVYSIERHGFHRRLYDAAGGSETVILGAEVAKVIPPQEEAEGVSVVLKDGRRYTGNVLVGADGVRSVVRRALMATINSPPGQSGAVGEDEDAADVIQFTGRVHLSGYTHPLDHLGPADEGIAYWMLYDRSILTTWPCRDHRQWFVGAVPSKLKDPNRSVWKHADHNTINQVYGSEYHPFAPDFHFRDVVKHAERVVASDVFHQTTFPPMAAGRIAMLGDASHAMTSFFGQGACQAIEDATELASALGMIDVRPTDAETILQGYRHSRERRGRDLVVFSDRFALLHTGRLLGSWGPFVRQMVYTWMPLWGWKWALQWLYGHQPTLVEQRNEAAKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7H6</accession>
    <name>A0A370P7H6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_81728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7H6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="8283" checksum="281D47C86194290F" modified="2018-11-07" version="1">MSQRPIPGQEEPRGKRSAPREGGGAGATTKGSWAPVGLLHHKLCRGSEVATSKLKAGFENCGEDDAQFIGPPWNERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7X4</accession>
    <name>A0A370P7X4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_307522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7X4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="38605" checksum="F925B2B9CF94490D" modified="2018-11-07" version="1">MSSSNQSHYYADPEKAKVFAAALLVKAGLMAEDARSMAECLVLADVRGVDTHGLARLPQYLDRVSNGRVNPQPSINITQKTPVVAHLDGDNGFGFVVATRGMDEAIKRAEIYGIGMVTVNHSNHFGMAATYVLQALKANMISLVFTNSAKQMPPFGGKETLLGISPFAAGAPSNTEVPYILDMAPSVVAKGKIRRAARRGESIPLGWALDADGNPTTDANVALNGSMAPIGGPKGSGIAILMDIMSGVLAGAEFGGQVGDQYKDTKPQNVGHCFIAIKPDIIMSTDDFKARMDILAQRVHGVSPAPGFSEVLFPGEPEHRLGLQRRAEGIPYTEAEKTLFTEAAKQYEVPELPLSDYPLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P803</accession>
    <name>A0A370P803_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_279142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P803"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14297" checksum="277132190C0A1038" modified="2018-11-07" version="1">MSDSSESISLQVTVHLKPEDLPKFWEAFEPTYKAVTAEPECTFFELYQAPDSPGTISWVENWSASKEWLMGVQLVKPYYRDYFAATEPLFIKPREAKLLKRVGAPFTMVKKTNGGLVIDFEVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8J6</accession>
    <name>A0A370P8J6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_75858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8J6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="109" mass="11819" checksum="203862077241DFF2" modified="2018-11-07" version="1">MTGQHKPCPRRAAFEKTSLAALVRPPVWDLGILSILAARYATIRSVVTPVVLVFATRTRPPAAPTPTPVPFHSSAHPPVTPVNGPRCRCMAMWRDRSVDLPARSACEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Q4</accession>
    <name>A0A370P8Q4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_338951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Q4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39859" checksum="771AB3446DACB079" modified="2018-11-07" version="1">MGLTLTGAYNTRQLQIVIINSILVVLSILAVVLRIWARRLQGLSLFIEDYLSIIALALALAVNALLFQSLHAGVGEHVDTLSAATVQEYSLNLYVMQLFWNTCLPVIKLSIVLFYQRIFPVPSMIFACRSIMLFLAVWYIAFQTTAIFQCIPIHHEWQKKTTKGHCIDFVPFVTTLAATNLCTDVLLLVLPTREIWKLQIPWARKIGLSIIFTLGVIVCAISIVRLENLIAISDSDITWSDTYSHLWTAIESSLGVVVSCLPSLMPIVRLIRDRKVRRSGKSFSRPRDGSSSYPSYVRPPYELSKLSNQVTSAASRTRHRSGSSRSDLIQKPVGDIEIVTEINQQVESASQCGFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9J5</accession>
    <name>A0A370P9J5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_239432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="396"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1853" mass="206086" checksum="7D95950F879ACFDA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAF4</accession>
    <name>A0A370PAF4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF914-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_256307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="426" mass="47149" checksum="103A9948FF20F31D" modified="2018-11-07" version="1">MSDTKARLAAQRSSPLPASYIPVAQSPEQVAPTLEAPQSGDTLPEVPATHVEKQDNVLAYLATKEFYITLFLGQVLAITNTACSTFSTLLVSEGTSIPAFQTFFNYFLLNAIFTPYTIYCYGLKGWTRVVLQHGWKYIILAFCDVEGNYFIVLAYRHTTMLSAQLINFWAIAVVLIVSFTILRVRYHITQVLGIMICIGGMGFLIASDRITGADDGNYSRADLIKGDLFALLGATFYGLANTGEEVFVSTAPVYEVLGQMAMYGMVINGVQAGVFDRNSFHNAIWNFQVGIYLTGYTLCLASFYCMVPLLFRLSSAAFFNISMLTMNFWGVLIGVGVFHYTIHWMYPIAFALIILGQLIYYLGRRVLGEARKPWLGRNQECGVSGLFTARRKIETAAGRSRSDSISTTCSERDPMLPHASVAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM6</accession>
    <name>A0A370PAM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_278265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="121"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="33223" checksum="339A75A2E9ED673A" modified="2018-11-07" version="1">MDYSFYSNHPQQPYPLYGVHGLPTPDQGNPAPQAEAIQGAFAPLGAQNYQPFDPNLRFQDPHAAAAFVAPPHSPPESLTKQSVSSNDYSNQNVDRASYDGDDQLLDQSLGRSSSEEKESLTPAQSKRKAQNRAAQRAFRERKERHVRELEEKVSNLENASNTLVADNERLKRELAKFTTENEILRATSTSMRQSGQRSTDEEPTTTGPLQYSPTDFKSDAGGGNGPAHRVTICGKTGEKLLDAGATWDLIQKHELFKRGLVNIGDVSGRLQGTAQCDGQGPAFRESQVLQAIEESAAAGNDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAN4</accession>
    <name>A0A370PAN4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_238510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAN4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="42414" checksum="54AE94E442A963BA" modified="2018-11-07" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGTLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFSIYLNYTRSLRFDDKPDYSYLRKIFRDLFVRESFQYDYVFDWTVYKYQKNAAMIVDANKKDKEAEEQQRRQGVAAAAPMGTPGAAKPGAISSQRRKVIERGTLDNTPETNRAVGGSDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB73</accession>
    <name>A0A370PB73_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_238785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="456" mass="51177" checksum="A61E19D8E7541C52" modified="2018-11-07" version="1">MTKAAGDISSVFPSLRPDYKPEPLPPRFRDLKLKYFEKNEKALKQSWERLLPSLEEEVHKIKAKGSDIIPSVQYSDVVNGTVPDHLLAEIRHRGSVVIRNVMPREKALDWKERIKDYAAANQERVKAFPPDSPAVYELYWTPSQAEARAHPNMLGTQRFLQRLWHSSDPNTPISTRNPLTYADRLRIRQPGDAKFTLGPHIDGGSLERWEDPEYSRVYTKILEGKWEEYDPWDAKHRVSANMDLYNGAGSCSMLRFFQGWLSMSNTAPGEGSLHVCPMLIQSTAYTILRPFFDPVSSQPVLDNTFPGAVPGTCQEYNPVTHPHLDLETTMVSVPEVEPGDYVAWHCDSLHSVDKEHRGKGDSSVLYIPATPMCEMNVDYLLKQRQAALAYSPPWDFPGAGGPGEIGFQGALDWSSVDAEGLRAMGMGSQPWEITDDMSEGEKAVVRAANKTCFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBA9</accession>
    <name>A0A370PBA9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 adaptor complex subunit MU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_238850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="446" mass="50529" checksum="5AAAFD6D70AD0D8C" modified="2018-11-07" version="1">MASAIFFLDLKGKTLLARNYRGDIPMSAVEKFPILLSDAEEESSAVAPCFSHEGINYLYIRHSNLYILALTKKNTNATEILLFLHKIVEVFTEYFKVLEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSASGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECLVESHSGSRMEYMLKAKAQFKRRSTANNVEILVPVPEDADSPRFRTNIGTVHYAPEKSAIIWKIKQFGGGKEFLMRAELGLPSVKGDDEHGGGMTGGFGGSMGGTGQGKAKRPINVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRMPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBD4</accession>
    <name>A0A370PBD4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_57946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBD4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="148"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="59239" checksum="7BADCA0FEB7AFBB8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBH2</accession>
    <name>A0A370PBH2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_278059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBH2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000128">
        <property type="entry name" value="26S proteasome regulatory subunit S5A (AFU_orthologue AFUA_2G15070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="276" mass="29765" checksum="DC9F5E2C35DF8DF1" modified="2018-11-07" version="1">MSLEATMIIVDNSESSRNGDYTSTRWQAQIDAVSVIHTTKMRVHPQSAVGLMSMGGKGPEVLSTFTSDFGGILAGLHRTKIHGTAHLSSSIQVAGLALKHRSEKSQRQRIIVFSCSPIEEDEKTLVKLAKKMKKNNVSIDVIAFGDLESDQTKKLEAFVENVKGGDGSNLAIIPPGPNLLSEELQVTPILGGDSSGADGAGPEGGDGAFGFEDAAENDPELAFALRLSLEEEKNRQEKEKRDREEQERKANLDNIPEEGSSGSKDKKEDGDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBL6</accession>
    <name>A0A370PBL6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_278079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="138"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="493" mass="54748" checksum="7343188912CDC1AF" modified="2018-11-07" version="1">MSDTPRPSLKLTFGKKKAPEEPSQRQPAAPPPPTETPQRKLTLKIARRPAPEAPPEDDKLKKKKKTSKKRPAEGPALQEPSTTVATTQPSGPKRLKLNPSKKPGVQSLRIKNKGLVPNRPVGVGYDSEASDTEIDPSIEEQFILRMLPGEDCEYLQRAISERRFDRSEISFKPLTREGRRAIFKIRDHQYAAALVDLPCIIEGMKSWDRRGWYKSADICQMLLVLGPVANEQEAMDYPLPSDILHPDDKTLQYPHGLTPPLRWVRKRRFRERISTRTIEQVEKAVEDLIAQDEAAVAPIRYELVDKTALNRAEGLVQSGDYDYEDEYDDEQDAEGEMEEGMEDGGLFDDFEDTLAAEMEAALAAGDEGEPGAAAAATGAEPPSDAGVYQAGTPMATKPSTPAPESSGDESDGSDDGDEPEDELDDEQLEQQRQMQQQREEIAELEALIRAETAKWEKMQNAILKGKLAKRIHDLKQDLSLKKVSIGEGDDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBQ4</accession>
    <name>A0A370PBQ4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_304782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBQ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752">
        <property type="entry name" value="BNR/ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752:SF2">
        <property type="entry name" value="BNR_ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="43247" checksum="C332F0C53D1479D2" modified="2018-11-07" version="1">MASTFPSDSLIRSVEKPYFYREAYLPAPTVQSHASNLLRMPNGDLLCAWFGGSLEGKPDISIYLSRLRCGESEWTEASKMTHDDTRSEQNPVLFHAPTGELWLLYTSQHSGDQDTAVVKYRVSTDSGATWGNEKVLFHDTGTFIRQPVVVLEDGAWVVPVFKCRVQPGERWLGNDDISCIRVSRDQGCTWTESEIPESTGCVHMEIQRLKDGSYLGMFRSRWADNVYLATSPDGVVWSAPQPTSLPNPNAGICFDVLPSGMVVLVYNHSSKLDALGRRQGLYDDIADGVDERKNQASAKDGRESFWGSPRAPLCVAWSDDKGKTWKHRILEDGDGYCLTNNSEKKLNRELSYPSMVCAEGIIHVAYTFWRQRIKYVQFKEDFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBW3</accession>
    <name>A0A370PBW3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycosyltransferase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_278142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBW3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57570" checksum="4096235F62C78730" modified="2018-11-07" version="1">MTWDESRKLFSHNMSQFAAIRSHRGFRIIFAAVAVIFALSIFMLLPPASSTSQVFGFGQGQKPATHSSSAGTITIDTTLITDISQYFADHPIQKPFKEKFGELGRRNRVLRDWLIQAEASQDSTTKSILHNAIEEVAIAQYPFLQPPKQTQSHHSRSSHHPVQDLRASFEPNSAGIVIPTSDYTLRYAAHLIASLRSVLNSTLPIQVVYAGDDDLSPTNRNHLSTLAASGPAITFLNILTAFDDTTLKLQTGGWAIKPFAALASPFEKVILADADAVFLQTPEVLLQHDAFVNKGTLLFHDRLLWKHAFEGRHEWWRDQIRRPSKEMDASLVWTEDYAEEADSGLVVLDKRRPDTFMGLLHICWQNTYDVREETTYKITYGDKESWWFGLELSGAEYEFSKHYGGIVGWENVDDKERVGVCSFVIAHVDAKGRLLWYNGSLLKNKGQAGMEDVYEVPNKWMIDAEWVKGSRKQDHSCMVGGEVRDLTKEELDVLQRSIAAARQVDTLVRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCF7</accession>
    <name>A0A370PCF7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_277819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCF7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="39885" checksum="A13CAE2D912DACB5" modified="2018-11-07" version="1">MASTVGQTITCKAAVAWGAGEPLSVEDVEVAPPKAHEVRIQVLHTGVCHTDAYTLSGKDPEGAFPVVLGHEGAGIVESVGEGVTSVKPGDYVVALYTPECRECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKARGKDLLHFMGTSTFSQYTVVADISVVAVTPKIPTDRSCLLGCGITTGYGAAVVTAKVEEGSNIAVFGAGCVGLSVIQGAVKNKAGRIIVVDVNDGKEAWARKFGATDFVNPTKLGGKTIQEQLIEMTDGGCDYTFDCTGNVGVMRAALEACHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRTQLPGLVDDYLNGQLKVDEFITHREKLSDINKAFEQMKAGDCVRCVVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCS7</accession>
    <name>A0A370PCS7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_277889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCS7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="649" mass="70702" checksum="661649215EC97904" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD35</accession>
    <name>A0A370PD35_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_238454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD35"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="123"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="604" mass="67298" checksum="9ADFABBC6CB676E7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDW7</accession>
    <name>A0A370PDW7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_254406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDW7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="439" mass="48304" checksum="83E32C971207CD86" modified="2018-11-07" version="1">MSRIFSHAISIPKTLSPLSTLNLRYSTAVRTIATMRKPAPIAIVGGGPCGLTFARLLETAGIDYVIFERDISAENALQFQGGTLDLHGETGQEALRRAGLIEEFEKLARRDATTLTVQDFRGNLRKTFGEGRDAPEIDRLQLRQLLLNSLPAHRIRWAKALQGIERTSKVGYGHIADCTLRFTDGSTESGFRLVVGADGAWSKVRPLITPAEPQYSGRMFIEGRISPGNPQYAAAHEMVGAGNSLASTRGCTLCIQQMSDRSYRVYMGLEVPSTFTRPGGEGDITKPEKARAAVLQHYADWAPHLRAFVEAAEEPWRPWPLHRLDPEIYLDGSPNWTRVPGVTLLGDAAHLATPNGDGVNIAMYDALVLFDSLMEEVRKKQSNTYQEGEDAVAVERAISAYEADMRARGRAHILDSIDMEDMMFAEDGTARMLAMIGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDZ7</accession>
    <name>A0A370PDZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_277705</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDZ7"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13592">
        <property type="entry name" value="PBP2_HisGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK40406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="307" mass="32924" checksum="2FA41EFF9AFA80D2" modified="2018-11-07" version="1">MDLVNHLEGRLLFAVPKKGRLQQATLDLLAGCDIQFRRETRLDIALVKNLPIALIFLPAADIPTFVGEGRVDLGITGRDQIAEHDALLPRGEVSNVEEVMDLGFGACKLQVQVPEKGDITEAKQLIGRNIVTSFTALTEQFFAKLEGKSEADKSELSTKIKYVGGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVVETISVLVKSKKTQNPLVDLIASRIRGVITAQKYVLCQYNIPRGELATASKITPGKRAPTVTALEEDGWVAVSSMVEKKKIATVMDDLTKVGATDILVLNIANSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE97</accession>
    <name>A0A370PE97_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_294950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="230" mass="24756" checksum="9BA7834891DBC98A" modified="2018-11-07" version="1">MLTVPEAGRDHRRTTKHHPVVEAEVKLPDVTGKKTTAGLRVPLPMLQEAQRSIVIEKLTKNVTESHLREIFGGFGDIQSLDLPMNKAFMTNRGTAYILYHDPADAEAAIAHMHEAQLDGAMLNFNIAEEALAVQDTAADLRRIVALQGRRHPLGGIAVLGIWKGMTSIGLALCRAPGRHAVLDPFLPSLSQTPHRQDGHIRVWTALSVAVAVARATAAMAIAVAVIGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEI4</accession>
    <name>A0A370PEI4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uridine/cytidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_328031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEI4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="36184" checksum="F8E6C1C2B9BBEA4F" modified="2018-11-07" version="1">MPEIIDDKSQHCIPFLLDRLQAHQARHPTNTPPFFLGLNGVQGAGKTVLVSTLQSTLRSPPYSLNVVTLSLDDLYLTHAQQEHLAASHPTNPLLQHRGQPGTHDLTLAKEVFSALRTGQRTAIPAYDKSAFSGQGDRVPASQWEVVNKEGEEKVKVVIFEGWCVGFRAWDEEVLRGKWEDAVRLREAAAAGQSEYKGRLGYVGLEDVRTVNEALRGYDVITDQLDALIHIDAQDLHFVYDWRQEQERTLRAAKGTGMTEEQVTKFVDGYYPSYELFTETLREGTFKPVPHATTASAPPTGWEGRQLRLVVDKNRRVQEIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFA0</accession>
    <name>A0A370PFA0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_328233</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFA0"/>
    <dbReference type="SMR" id="A0A370PFA0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000005">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK40872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="55623" checksum="7A77C326E408432B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG00</accession>
    <name>A0A370PG00_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_284623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="14236" checksum="7A5C9ABF326440DB" modified="2018-11-07" version="1">MAAKTRNIRRRRPSSKRSTYQQRTRRKNNPFLKAFEYCNLCEADIALVIRLKHNGQVFEFNSNSQWHPSREELVGNLYDSLKDTWYPKPREITWDELAAQYEMGRPRCKILGRWQRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG43</accession>
    <name>A0A370PG43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_336970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="53594" checksum="0F6CBE84A0A48A87" modified="2018-11-07" version="1">MIRHCRRFSLSSPFVAPFNRLSCTSSTSRPFWSPGKLNPVFFARLNSTMAGDRVEYNWIKGVETLEEYVPGGYHPIMVGDVLHNRYYIVDKLGSGGYSTVWLAHDTVIKRYVALKVNTADALPREATVLKSLSTPRPSTSLLHQGPDLVPILLDQFEVQGPNGTHTCYTTAPAQSNLREISFSRLFPLDVARALCYGLTQAVVYTHSQGYVHGDIHLNNVLIKLPSNFDTLSVKELYEKYGEPETVPITRCDGKPLPPNVPTKAVKPLFLGKYAETLTLADVRPLLSDFGEAFAPASEVRLGKDCHTPPAFRAPEARFDPQGPLTYSSDVWSLATAIWEIVGMKPIFSTDIVPDDEIVAQHMDVLGPMPQEWWQRWEGRRKFFTEDGRPTKAYLENKWPPFEESFEIDIQKWRRKWRGAIEEEEKVVFLDVIRRMLAFRPEERPTAEEVLQSEWMVKWALPDYKRSIDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG99</accession>
    <name>A0A370PG99_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_303063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG99"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="609" mass="68906" checksum="3D6B093B43017B9E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGU2</accession>
    <name>A0A370PGU2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_266952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGU2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33843" checksum="37644BFEC1C60869" modified="2018-11-07" version="1">MSDPTLYLYTSLTAGSSHIVTATARLETILKANKLPFRAIDVATDDVARKLWGRRSKGKKLPGLVKFGTVVGDLEQVEEWNEYGELRMQVNSVEDIDSIPATSTPIAPPSAASTPTPEPTTLKQSTIKIQSPPSKETPKDTAITAAMRQASGEAAAKAKGSGTQPTPAKEAAPAKEAAPAKEATPAKEPAPAVTEQKETPKETPKETPATGEQSQAGKEDTVRGNEAAPDAQASKPKRPPLVPEVAAESSANFHADAAEALGMVQHHRGSIISATSKEEQEKVAQDLRKSISGGQQDLLKSLREDNAARTDQEETIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGW2</accession>
    <name>A0A370PGW2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_336944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGW2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="35377" checksum="BB3D8A54969A83E4" modified="2018-11-07" version="1">MLGKRLFSTFRSLQHENPLGLPRSGTPPSLRSRRGLPEKRKIRDVKKVIAVSSAKGGVGKSTIAVNLALAFARRGIRTGILDTDIFGPSIPTLLNLSGEPRLDDKNCLLPLTNYGLKSMSMGYLLPSTQPPPNTDPTERAPMDPTPISWRGLMVTKAMHQLLHSVSWGPLDVLFLDLPPGTGDVQLTINQEIILDGAVIVTTPQDIALRDAVRGIGMFQRMDVPVLGMVRNMAFFACPECGTQTKIFSQGRHVHEGADWGVEAECRRLGVGFLGDVPLDARVCEDADRGVPSVVAEEGKEGKEGVRRKAFLDVAEQVAKKVGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHC7</accession>
    <name>A0A370PHC7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_267093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHC7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="208" mass="24726" checksum="2FA7141329D6744C" modified="2018-11-07" version="1">MAHHGQSQTVAPVEPCWNYPIYQSYLARIDPAAQPYRNVVDHFWFNFLRQYFSQTEGCAYERHICTTHPGPRRHWNVFLTNLREQQAHHVIAVEARWFSTDTAPGWENDYDWRDVRETLRCHMLRDWTMRTTVQTTYGIVAVGDRVRLYYMSRDDLEGELRTWNGNPVDAPEADESPILNIQDLVDRERIHQLMLRMRQDVLSGNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHH2</accession>
    <name>A0A370PHH2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_28473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHH2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="246" mass="28367" checksum="AD9CC0DC4FE94D09" modified="2018-11-07" version="1">MGDLGPYLEYDGEDYICSICDRYFRTDGALFAHCRATTRHEWCERCRRVFISEASKNAHIQASNKHHICRSCREATDFESNQDLRDHLVGYHHACLECNIFLESAEGLRSHDISDHCLCVVCDKYFSNENNLRMHRQKHQAKTLECYGCYHNFKSFSGMLIHLESGACQSGVTEDTIDDLAKECYQSRRYTVETDGGWRYECPECEKEFTKLSALYQHVEDVPACSHLANGNGCLAKLERFMASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHH4</accession>
    <name>A0A370PHH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_284391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="552" mass="58283" checksum="4A5B4A77D20EC750" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHU3</accession>
    <name>A0A370PHU3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_215992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="647" mass="71634" checksum="E463E86B5F2D586C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIE6</accession>
    <name>A0A370PIE6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_235910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIE6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="283" mass="29428" checksum="AAD34508F9A84CEE" modified="2018-11-07" version="1">MAPLQTVLITGCSANGIGSALAVALANQGHHVFATARSPSKIPSSLTTLSNVTPLQLDVTSSESVAAAVKAVELHGTGLDILINNAGSGYTMPLLDVDLTQAQQVYETNIWGPLRLVQALAPLLISCGGRVVNISSVGAVVPTPWIGIYSSSKSALSNLSETLRLEVAPLGVSVATLMIGTVTTPFHANEPRFTLPPNSRYAAIAETISRWASGEASPKGCSAQELADLILPDVLGTTGHGMFWRGPNSGAVKFVSQWVPGWLADRMMSTGQGLDELAASQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIX5</accession>
    <name>A0A370PIX5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_276791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="354" mass="38203" checksum="52D373879D38A1F1" modified="2018-11-07" version="1">MASTSTLELTPEFLAQDRRPQARIGIGVVTALSGVIVLIRVYARWFMIRSFGWDDGLICIAMLLNIAVMALTTQVLRYGAGLHIWALDTAETPLLYKWLVAAQLVYMIALWTCRLSGLAFYRRLNPMPQFQLYLQISFAFVTAVMLAQVLIIALQCIPLAALWGGATGKCLGSKTVFISTAAMTIICDSLILLLPVKIVFSIKANATRKAALSVVLCFGVFAVMTSVARIISMIPAIQKTDATWYFSVVMVWSDTEVSTAIIALSLPALKGLVGAVAGSTRKGTDQTPGSNGGPDLHLQNVHAGGGHRLYEGPGSYPNEARAGLGDNASQEALWVDTTARIHVKNSVRVSVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ84</accession>
    <name>A0A370PJ84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_283680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="389" mass="44371" checksum="4696E59E01064DD7" modified="2018-11-07" version="1">MAILNLVLSASYLYIFGTIFFDIIHYLLHQWSRSRWRILRFLSRCHQYHHLYYPRSLQFNQRYAKPNALIALPLELICQLLGSIIGWILATILSLHVKRLDTNALSLVLVVQTIRSLFVIISNGQDSNHIALDKVPKDHSWAFVGPEYHSLHHIYPDRYMGSMVKLFDWVAGTAYSLKNKTVVMTGGSGAFGQAMEKQLLAEGVKSIHKLQFGKDWYNEDFSRVGPTLEGADIIILAHGTKGSDAMDSNCTSSVRLIELFMQHMSAQSQRTKVLPEIWYVGSEAELHPAWGGPEMVRYTASKRAFLPYARALYKSDKVIYRHIVPAAFDSRMGKAIVSADWAARCTMSWIRRGAYYVPVTYTGLAYLNFFKFLFGASAHLKWMDKMENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJN0</accession>
    <name>A0A370PJN0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_319550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="318"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="582" mass="65611" checksum="265CD382ABFF5D60" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJQ4</accession>
    <name>A0A370PJQ4_ASPPH</name>
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            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_283783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
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                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="518" mass="60095" checksum="CA200CA728ADB0EC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJQ6</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">M752DRAFT_300648</name>
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    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
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                <person name="Makela M.R."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
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        <subcellularLocation>
            <location evidence="3">Membrane</location>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="75569" checksum="D54A0BFFEB37A6E8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK11</accession>
    <name>A0A370PK11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_234600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK11"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="579" mass="63614" checksum="196D6540CE949E53" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK40</accession>
    <name>A0A370PK40_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class II aminotransferase/8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_300827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="38"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="431" mass="48531" checksum="126B67F3ACE5779C" modified="2018-11-07" version="1">MSTGRDILCQNLQVLLDRRRAEGRLYEPASPDEYEGTVDFGSNDTLSLSASGLLTEAFLHQLERHPHFTIGANSTRVFEGTRQYIVDIERDLAHFHNAEDALFCGSGYDANTAIWSAIPQPGDFIVFDELVHSSIREGMRLGRAKSIPFRHNDSLSLRQRLEELRDQNGEVAEGRRLVFIAIESIYSMDGDVAPLHEIVKIAYDTLPRGNYILSVDEAHSNGIIGPHGSGVVSLYGLENEFSIRLQTCGKALASAGAVVLCNSTIKEALINYGRNIIFTTAPSFTAVAAVRAAYEILATQEGHRRQDRLQKNIWYFYWTLTKHPQWEDIKARSILSLPTEKTWYTRPFKSPVVPIITKPKQANSLCKRLRRAGYWVNAVDYPTVPKGTGRIRLMIHADNTREEMDGVIQLIMNWAIEQYQPVEPVQAMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK84</accession>
    <name>A0A370PK84_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_18232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="112" mass="12286" checksum="08A905EC5AC1240F" modified="2018-11-07" version="1">MKPPLGASTSPSIPFFPSPSSSFSSPLPPSIFLPHHHHHPHPHLHHHHHRPILTTGVCHQRLTSTASFFSPARLSPLSDRVSPPPTTNTTTIHPVPFHPTNQSLNTHVTIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKI1</accession>
    <name>A0A370PKI1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_215082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKI1"/>
    <dbReference type="ESTHER" id="aspnc-faec">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027160188" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="270" mass="28563" checksum="CA11A59E6BE721CD" modified="2018-11-07" version="1">MTRSIFIHTLLALSALTSVHGANSPGCGKNPTLANGVHQINGREYTLKIPDDYDANNPYHLIFGLHWRGGNMDNVVNGDSIQPWYGLESRAQGSAIFIAPNGLNAGWANTNGEDVAFIDAIMEQVESDLCVDQSSRLATGFSWGGGMSYSLACSRAKEFRAVSVLSGGVISGCDGGNDPIAYLGIHGINDPVLPFDGGVELAERFVGNNGCQPASIEKPQSGSNGWKRTDFDSCSKPVSFIAYDGGHDGAPLGVQSSLAPDATWEFFMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKY7</accession>
    <name>A0A370PKY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_335598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="314" mass="35394" checksum="9BD03FA2121E5F6B" modified="2018-11-07" version="1">MVNVAIAGGTGAVGRTLLEVMASQTRHRAFALTRREPTEDEQLLVPTYQVNYEDIDSLKLFLEEHNIHTVISAFGINATSLATSQLNLIKAADASSVTKRFIPSSFAIPYPEEDVSILPPLEHYFASFRALKISNLEWAPVYNGTFLEYIAPPTLKSYHPHSVLVLDVEHNIAAIPGDGNTPITFSYTFDIARFVVAALDLEKWPQELRIVGDELTFNELLKLAEEVKGVKFDVVYDDIMKLKASQITELPGHFKSYNKFPKDRLQWFLAIFETWMATGQARVAREGSLNEIFPDIKPLTARQVMEQYWKSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL44</accession>
    <name>A0A370PL44_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_251868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="59515" checksum="3114396E8505FA8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLW5</accession>
    <name>A0A370PLW5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_314311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="4">
        <location>
            <begin position="724"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="873" mass="98142" checksum="B30586F78DB176F7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM18</accession>
    <name>A0A370PM18_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_249884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000084">
        <property type="entry name" value="Heat shock protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016968423" evidence="10">
        <location>
            <begin position="39"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="947"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="968"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108701" checksum="A23B5ED6CA44629A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMA7</accession>
    <name>A0A370PMA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_326181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="45"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="808"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="163"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK43323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="880" mass="98934" checksum="0252C781C3676C5F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMI2</accession>
    <name>A0A370PMI2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMI2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="35637" checksum="8D1B8C50DB9C3A91" modified="2018-11-07" version="1">MSIPPRSTSFLVYIAPSRLLSRQIPYQTLQLHRKNFSSLNPTANMKIAITGARGTVGRAVVREASQAGHSTVQVDRTDTEYDGTPNSEMKTADTANNYEATLEAFKGCDAVIHLAAIPDPIGKDDQVVHNNNVTSAFNGFYAAAQLGIKRFCYASSVNAIGLEYATRPLQFEYFPVDEEAPPNPTDSYALAKQEAETQARTFARWFPGMNIACMRIHAVASREEAQKGHNENWEDSAVKSLWGWVSPDATARACLLSVEKAEKLNGCEIFNVVAPTTTQDTPSIELAKKYYPDTEVRHELKGNQSFFTAEKANRILGWVHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMT2</accession>
    <name>A0A370PMT2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_335055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41630" checksum="88DC0EEEF776E9A6" modified="2018-11-07" version="1">MNTLSCLALSIFLLSIIFTRYRKNLPSLWRTKHAEPGCNDLKKMAPYPAQPIKGRERYRVMMDVRRLDVENWLTVDKNYMDEHEVRSQLLEKEKSKVLQCLPESYDACLEALEEVVEFLCQRFSNVFEQKKCGDETTVHNKMTGETFSFGGKNKDVDPLEIAVRLTMEDLSILMKNEEDEYYLAASASLFPVGWTVQDRIGWTISKLHNPVPLWHQQVANSVSKFLARLTPASPMERSNYFVEVKRPDEDLFEILYRPTSLSEENPDPTPQDIVIRRERQTFRRLPRTGALVFGVKTILTTLDELPMQELQNLAKEIKSWPEYVGEYKGREVWGPKALEYCEKKSQLYQQDPEKMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW9</accession>
    <name>A0A370PMW9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_158252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="48041" checksum="980B0E31402F4790" modified="2018-11-07" version="1">MADLQGRKIFKVFNQDFIVDERYNVTKELGQGAYGIVCAATNAHTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEETLSRIGSPRAQEYVRNLPFMPKIPFQRLFPNANPDALDLLDRMLAFDPTSRISVEEALEHPYLHIWHDASDEPTCPTTFDFHFEVVEDVQEMRHMIYDEVVRFRALVRQQSQAQAAAQQQQIAQQTNVPIPDNQQGGWKTEEPKPQEALAAGGGHHNDLESSLQRGMDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN51</accession>
    <name>A0A370PN51_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_233342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN51"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="113"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="619" mass="68346" checksum="0337BA71A7B83058" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN96</accession>
    <name>A0A370PN96_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_291836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN96"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016704135" evidence="4">
        <location>
            <begin position="19"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="605"/>
            <end position="606"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="624" mass="67523" checksum="427B425B3436CE14" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNE6</accession>
    <name>A0A370PNE6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_313585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNE6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="57853" checksum="E6F3AD56161C4D12" modified="2018-11-07" version="1">MALLLTLTLIILTLLIKPLFSYFTTKTLTKYPRLNPLSNITTLSYTYEHRHPFRTQRLYNFHHQHNHPIIRLSPTALSIADPKAIPAIYGHGTPCLKDDVYALTKGTHTHSNMLNTISRDDHSRKRRMLANAFSTKNLENWEFKIVDKVERLLRQLDGRCSSSSNGVMDGDEVDLRFWLNLFTIDAIADIGMSIKLGLLDRGTDEVGVDGEVVRYIECLHRGNRVSSWVIGASGWVGFLRGVSRVVSPYLREQWECGRRFGRVVRSLVGQRVSVQEGGDTLSDFLGCLIEDKRGVGRELERGEIEAEAGLLLDAGSDTTAIALTNVMYYLIKNPQSLIKLREEVSGAVLENGVAPYAKVRNLPYLKACLEESLRLSPPVPRGLERKTPPEGMYILGERIPGNFTVSVPTYAVHRDPEIFPDPEAFRPERWLEDDEKVKQMRAVFIPFSSGARACIGRNITFMEQQILVATLVHRYEFALPSKDWMLEWEEAFNLWPGRMPVRIWRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNR9</accession>
    <name>A0A370PNR9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_145889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="794" mass="86831" checksum="03DF2CC2C8533397" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPI9</accession>
    <name>A0A370PPI9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_249601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPI9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="460" mass="50844" checksum="65620ABB5551F446" modified="2018-11-07" version="1">MAARPQNIGIKAIEVYFPRQCVDQSELEKFDGVSEGKYTIGLGQTKMSFCDDREDIYSIALTTFSSLLRKYNIDPNSIGRLEVGTETLLDKSKSVKSVLMQLLAPHGNTNVEGVDNVNACYGGTNAVFNSINWLESSAWDGRDAVVVCGDIALYAEGAARPTGGAGCVAMLIGPDAPIVFEPGLRASYVTHAYDFFKPDLTSEYPVVDGHFSLRCYTEAVDACYKAYNAREKTLKEKVQNGTNGTAQDDSKTALDRFDYLCYHAPTCKLVQKSFARMLYNDYLTNPTHPAFAEVAPELRDLDYATSLTDKNVEKTFMGLTKKRFAERVKPALEVATLCGNMYTATVWAGLASLISHVPFDASESKRIGLFSYGSGLASSLLSVKIVGDVSNLVEKLDLKNRLSNRNVLPPQSYVDMCALREHAHLKKNFKPSGNTETLYPGTYYLTEVDDMFRRKYDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPY5</accession>
    <name>A0A370PPY5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA cleavage and polyadenylation specificity factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_231074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPY5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="786" mass="87853" checksum="1EBF7FA0CAB6052F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQQ6</accession>
    <name>A0A370PQQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_231495</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000381">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="985"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1241"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="1997"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2358"/>
            <end position="2390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK44520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2390" mass="269919" checksum="BB8CADC8E34F8FFC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQT2</accession>
    <name>A0A370PQT2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="7" type="ORF">M752DRAFT_141053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQT2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="486" mass="54619" checksum="C5F4C296E615C57B" modified="2018-11-07" version="1">MSSQLGHESSVGSPLSYKTDSNAFTREYAESLDAQDPLRDFRKEFIIPSKVDLKRKTLAIDDSSKDESDPRCIYLCGNSLGVQPRNARKYIGYYLRTWAIKGVTGHFLPHEDQLLPPFVDVDDAGAKLMAPIVGALESEVAVMGTLTANLHFLMASFYRPTQERYKIILEGKAFPSDHYAIESQIRHHNLRPEDAMVLIEPEDRLKPILRTEQILRVIDEHASSTALVLLSGIQFYTGQYFDIEKITAHAQSKGILVGWDCAHAAGNVDLRLHDWNVDFAAWCNYKYLNSGPGGMAALFVHERHGRVDMDKVGNDEEPFRPRLSGWWGGDKKTRFLMNNNFLPQTGAAGFQLSNPSVLDMNAVVASLELFNRTSMAEIRQKSLNATGYLEHLLLNYPADFPTGKRPFSIITPSNPAERGAQLSLLLEPGLLDSVLETLEEHGVVVDERKPDVIRVAPAPLYNTYTEVWEFCQIFFEACQKALKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR36</accession>
    <name>A0A370PR36_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_325594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR36"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="580" mass="64536" checksum="CDF5E13D80E6B2BD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR55</accession>
    <name>A0A370PR55_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">M752DRAFT_313442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR55"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="207" mass="20935" checksum="2CA9655A6D90F026" modified="2018-11-07" version="1">MASRSPTAVTPLPKSSVAPETPMVKDAPATPQAVPFPSPQTFDIVPPLHGLLSRLLSPPTNAAGVSNGVRAADDPTGAAAPTGPPSGTPGQPQSQQQAGAENTNNAGVLGTVTSAGPGGAEISGLGSGTSPALDIKDLPTEVSSIKIRIQKAQAVVENLPDVDRSVADQEEEIQELEDRIAKLKSVISDFGQMASSGGARKHKSQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSL7</accession>
    <name>A0A370PSL7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_264009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSL7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000958">
        <property type="entry name" value="RNA binding protein (Rbm8A), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="160" mass="17481" checksum="E947F18AC0C24D1C" modified="2018-11-07" version="1">MSTEMEVDPPVAQEEEVPAQSGNNTSDPRTQASAVAVRSIEGWIIIATNIHEEASEEDVTDLFAEYGEIKNFNLNLDRRTGYVKGYALIEYSTLPEASEAIKALNGSKLLDQTIQVDFAFVRPPPSNKGKNAGQRGGRGGRGRSRSRDRSRSPGAEEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSN7</accession>
    <name>A0A370PSN7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_134012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="306"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="626"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="876"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="102821" checksum="6EB47CA073D93D7A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT31</accession>
    <name>A0A370PT31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_229463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="57739" checksum="F4C14E31FBBF75A1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTP8</accession>
    <name>A0A370PTP8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_317484</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTP8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000017">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF108">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 20" id="KW-0521">NADP</keyword>
    <keyword evidence="13 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="290"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDK45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="695" mass="77763" checksum="FB7ED3D350F7B554" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTQ3</accession>
    <name>A0A370PTQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_333377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="22409" checksum="B9D5D2B5FC493E22" modified="2018-11-07" version="1">MTFALPLGSTAELHNRLQTEQHWGYTIYRTTFSTQADAAFPTILRYLDAFDPAIYEGIWARYQSTVIEDAARFTGASIESVRDHFEASVENQDRRDLFNSDRMCIVIDEESLLTLPDASVEGLEAEGPTHVHESTRFLKVLEAWPTVDEYDSFPGWMKCSPRALWDLWKMMGDGEEMRNSWEDMDEMDEGVYCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTT1</accession>
    <name>A0A370PTT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_333384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTT1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK45603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="358" mass="38940" checksum="BF346DFD1927B297" modified="2018-11-07" version="1">MAPSTNDSPVGISTSPYACKVGINGFGRIGRNLLRASLVRSDIQVVAINHTCVTVEDLIYLIRYDSSMGDLDEDTTIQIISENRIIIDGAPITLTSERDLKKLKWDALGVDYVLECTGKFTKSHQAIDHITYGQAKRVLISAPSDSPTFVYGVNSDLYRPTQENLVVSNASCTTNCVTPVLKVLHENFGVAQGFLTTIHAATRSQQVLDGYSKKNRRLGRGVFNNIIPTTTGAAKAVASVLPELSGKVTGVSIRVPTPNVSMIDLTISTEKPTSLSEILSTFRVASKSSMAGVLRVTDEELVSTDYNGSPYSAIIDAPACTELNPQFFKIMAWYDNEWGYSNRLLDLATHVHAAQNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU12</accession>
    <name>A0A370PU12_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_333283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="57312" checksum="D20FD7171592FA2B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU18</accession>
    <name>A0A370PU18_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU18"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="13772" checksum="7B5073E46A91D2B8" modified="2018-11-07" version="1" fragment="single">MCYVGISNRHNNALHRRLIDGCGNCPNRHLQAYSRNKYMSDLHNIFSTEAVDMDCRSMNGQTAHAPAEELSGARSSDSLEMLIRYEIQLYCVANSSQAREILVYIVKVPSRGVHPSMQRKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU45</accession>
    <name>A0A370PU45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_263322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="514"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="672" mass="74519" checksum="0C181677E73F4269" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUJ9</accession>
    <name>A0A370PUJ9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_312072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="620" mass="67567" checksum="4E14F73490DECD46" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVF4</accession>
    <name>A0A370PVF4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVF4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="295" mass="31549" checksum="626E1746FB817BF1" modified="2018-11-07" version="1">MSKVASTFSRLVRFVPKSNPAKVLIGEPVDAAVDVGLAVYQGKDVAVRPFSGSSVLNPGQKTDTTETIERVLSPLAQSEVGSIRCIGLNYVSHAAEMKLSIPDVPTLFMKPSTALSDPWPAPTVLPKLTQIDNTGDYESEMVIVIGRDAKDVSEAEALDYVLGYTAANDISSRTYQMNQSQWCFSKGFDTSCPIGPVLVSAAQVPDASKFHIRGSKNGKVLQDCPLTDLIFNVPQLVSFLSQGTTLPAGTIILTGTPPGVGAAKNPKEFFKHGDEFAVELQPHVGTLITKIENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW71</accession>
    <name>A0A370PW71_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_309929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW71"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF250">
        <property type="entry name" value="MFS-TYPE TRANSPORTER AFUA_1G00970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="44381" checksum="9167738EC6CC06AC" modified="2018-11-07" version="1">MAHPEDAPTDSPPSEYTPRAVQTLLGSFCGMFCTVGFVNSFGLFLEYYKKDQLSDQPESTIAWIAAIDIFFIFGVSVVSGPLLDTIGPRLLLCIGSLGSVFSIMMTSLCKELYQFILAQGILLGISLSLLTCPMIALVGQHIKIKRGAAVGIVIGGSSLGGVLWPIIVNELLQKPNIGFGWTMRIVGFIMLPLLTVTCFCCQPAAPPPSPSPSSQHQPEPQSEKFSPEPQSPDPTKDTETPLLQNRTLHLTCLSFFIIYFGMFSPFFYVSSYGVARGFSSSLSFYTISMLNGASLFGRVIPGILADKYGRFNVCLVFTILAGIVALCWTKATSVAGLVVFSIAYGFSSGAILSLQQACALQLATPKTVGLAVGVVMGATALSAMAGIPISGALVQKYGFLALSIYAGICRYCISAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWB1</accession>
    <name>A0A370PWB1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11 12">Catalase-peroxidase</fullName>
            <shortName evidence="11">CP</shortName>
            <ecNumber evidence="11 12">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">katG</name>
        <name evidence="15" type="ORF">M752DRAFT_103166</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11 12">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="11 12"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWB1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="130"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)" evidence="11">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="762" mass="84285" checksum="3F1E75DF8D420C5E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWC6</accession>
    <name>A0A370PWC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_289998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="132" mass="14979" checksum="20896D4E68B44A61" modified="2018-11-07" version="1">MKPPYLAVAIYHPRYGNFQHWALHLHSDTEDLIFEVDGEHPCFQKVVSNGLPSDNLGFIESLFVCQIGSLDIPTVKDVVDATPVDNETLEWDCQDYVLDILEGCEREAVLEDEDADYAEAMEILRSRRGPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK8</accession>
    <name>A0A370PWK8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LPS glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42480" checksum="1D7532D96CE67C9F" modified="2018-11-07" version="1">MAAMMTPGSPVRLVPGPRRRSSNLVILLLVVIALLWSLVFHQNIGRGRHVTLDDIRDPLDAIVNNTLGFEKIFAISPAQRLDRRDAIVLASSATGFHVDFIDGLILDEDSAKELNDSKDSETVSVSRPHANAVQRIVADGIASALILEDDVDWDINLKMQLKGLALGSQQIPKINAPERNATTDSPYGDSWDVLWIGHCGMKCNSSSPVQVMPHDITAMPSRYLPPYLYDAPAGTGNNVRMSCIIEKAACSAAYAITYGASQKILAALTRLTDDDNLDFPDLLSELCYNGSLECYSSYPSLVGRWKSSRKEEYSFDNDQEAIDRQISHSSGVMYSTLGNIEHILGGESTVRASIDDAIVPKLNPDLFEVPHSFLQWADRKGGHERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWX4</accession>
    <name>A0A370PWX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_207752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="39015" checksum="B3658C9DBD0DF84E" modified="2018-11-07" version="1">MFERNADIAVSPLHSLPVISGKGKLPKQSFSKGAHSGNSGGEIPEYNSTSPETLPPSPSYITTIFYLAYPPPHSSSPFRQIKPRLLLQLLQQAARKNRLHPVFEVLLTAPVGLQNYQKEVRCRSGDIALVHSDYYSDCTLPDGSRAKYSGNEEDEDERAGKIKVLAVIRDQRKIHARRDHLGQAADNDSGPVRFFFSCGAIWEAITAQNGNNYQLVAVDPGESTVNGDLKLISWTRECPSHENGGNETRRDIRFRLSIVNGDFQELPIVATATIQSIQVMFQPRKHDDLKSPSSCRPSSSLPSISRERAQLLTTRDNPFSSLDVSISEPLYLLCLVITSAVWVTSSEGWLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX59</accession>
    <name>A0A370PX59_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_63649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="194" mass="20895" checksum="470588430B4A327E" modified="2018-11-07" version="1">MLDAIQSLDCTRTWGGLGGFPPDFLVVAFLAGFFFAAGGKGEGRGERRGNGREKRSTESSNRRSSALPGPLQVWSARVPCVRAEWLREGGSWAGASSTRRISCDQQPVRRAFRNSHEAIPGPFSCCSAFWSDRNLPYAGYCMPAVIPSAVSYGKQRVSARYPASGRQVTPSHSLSGKMRDARASLPVLGGPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXA4</accession>
    <name>A0A370PXA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_332134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="31694" checksum="FC5FA585C8C8BEF8" modified="2018-11-07" version="1">MAGQQLTWLVTGCSSGLGEALVRAILDKGDKVIATARGSKGVSGTDRLSSLKDAGAAVYELDMASPEEEIKRQAQDIWDKYGPIDVLVNNAGYIDISTFEEMTDDFLLNSLRINALGPFTLTRALLPHMRARKTGTILFSGSVGTYYGVPCGGPYVGPKGLIEGMVPAFAMEVAPFNIRVSILTYGHFRTQVMAAGVIQDRNPTRLPEYEKLNQEVYDGCLDWNGNQPGDPRKGAELVVEAVKGEGRCKGMELPLRLPLGSDTFGIVRNSCEELLKVWDEWDGITSKTDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXV2</accession>
    <name>A0A370PXV2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_332286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="32722" checksum="4DAE21BCAB193996" modified="2018-11-07" version="1">MSSAEESPAQRAARLRRERREAKIKGDGAARLDKITSLSGRTPASLREETSPSPSPSPAPAAAQATTTALSPSPSPSPAPEPRTTQPSFPSQAPQQQQELDPETLQAQQELFRALLRQSGQPGDSPSGSPGPQAGGPGGMGGMGGLGGEADDPTLKLLSSLMAGDTSALGEGSLPGGQSPADLLTGLGVPPFVASMLGEATRKKSDEEKREILVWKVLHVVFSVLIGVYLLVLIGSSVATFGSQPPPPATARNPFLFFTTGEVVLTGARVMMKRGGGGLGLWVQLVRDIARDGSIVLFLFGMANWWHREWTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXZ4</accession>
    <name>A0A370PXZ4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein Ucp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_332335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXZ4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30989" checksum="3911F6EFFCD88181" modified="2018-11-07" version="1">MLTSGLTNASISKSLLIYTIASSVALAIFDLKHLTSIQVVPHIWQYGQFWRILVWQVAGFANSTEALFAAMLVYHLRVVERAWGKRKFATFLLTTLPYTTLLPPLLLILVLRPITLGKMNYLPSGPVATIFALLAQYHASIPSTFRYRISTSSSSDSNDTKDQPQQSNKSLTLTLSDKSTTYIVAAQLALSQFPAMIVPAAVGWLVGVAWRMEFLPGTGAWRVPAWMVGEKERRVVNGAGGGDGGRYEDLRRRLEGEAIAASASSSATGAAGETVGQRLRRSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY86</accession>
    <name>A0A370PY86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_228205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="320" mass="35027" checksum="C24D55D88B327191" modified="2018-11-07" version="1">MDRSNKPAAIGVGASLPQPTISLRDNTVEATLPTGESVTVHLYGATVTSWKLANGKEQLFVSEKAHLDGSKPIRGGIPVVFPVFGPPPSNHATSALPQHGFARNSNWEFLGKSSSEAFGRDRKEGGDAVKLDFGLSHPMLSEEFQKAWPYQFGLVYSVTLTKGSLETSLQVQNQGEQNFDFQVLMHTYLSVEDISNIRVKNLQQKEYLDKTQGGAAITETSEAVEINKETDRVYKALDPKVPIIVSTASDDQPLFSITREALTDVVVWNPWIEKAKGMADFGPDEAYKNMLCVEAGSVAGWQTLEAGESWEGGQTIRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ49</accession>
    <name>A0A370PZ49_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_1606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016678792" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="55"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="288"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65766" checksum="02E0F2ECDB900AF0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZE3</accession>
    <name>A0A370PZE3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_280552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016485704" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="591" mass="64695" checksum="50A7AD66981CBEE2" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZP6</accession>
    <name>A0A370PZP6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_322671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZP6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479872" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="45"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="559" mass="61688" checksum="6EA1DD7D1F432A18" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q063</accession>
    <name>A0A370Q063_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_331592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q063"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="39550" checksum="26974F2A20157E6B" modified="2018-11-07" version="1">MGGSIEQQDDVPTSSMTIAVRIIVLVLAIPTTLVCVLRLYLRKFVLNNFGLDDWLVLVALIGVDLFSALAYIITYYGLGRPMKYVPTDHLVVFLTLEYASQCAYLVIAATVKASLLIFIMRLFPTRFVHIAGKALLGIIAAFTLSGTLALVFQCRPVQAAYDKAITNSSCYPTETSYAILMMQGVIMFVLDVSILVLPIWPIWQLQMPIRRRILVLGLLCIGFTACVAALVRFSTLKFANDTTNFTYSASTSLIWMEIEFNLGLMSGSLPSLRKLFKLGSLFPTSRSTKTQQSYTSDFELHRHSWTITGITKKTEIQRAYERSESQEFIAPIYGQGELTTTTKAYADGETSSASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q130</accession>
    <name>A0A370Q130_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_323028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q130"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK48133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="32025" checksum="D05FCB30718ACFB7" modified="2018-11-07" version="1">MPRKSTSSSTPGDDGGPEQSQSQRIHSQSPSDIVHLPESTGQMVEATEQQLKARAEGGVSIEDYLLPRSLTLRLAKSVLPPNTSIQKDAVLAIQKAATVFVSYLSSHANEATLKRTVAPSDVFSAISELEFDGFRTRLEQELEAFTELKAGKRRAKKGDSGTTAAAAAEGVGKSGVAEEEEEDGDRGVKRVKRAEGEKKNGIDAGGEEEEGDETQEEHEQEQEQEDEEEEEEEEEEDDEEEEEEHKGDGDDDIDRVEDLDRARRPTNPDVEGDDSDSEDEDGPGSQLRGDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q166</accession>
    <name>A0A370Q166_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_11734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q166"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="59" mass="6133" checksum="5E78D3806DD7CF63" modified="2018-11-07" version="1">MNRLEQLHGSAVASGSSSSSSSSSSSIRCTVSSMISPPTTMTSYHPTNPNPAPINSNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1C9</accession>
    <name>A0A370Q1C9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_244494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1C9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="189" mass="20995" checksum="26629EC336D2A39A" modified="2018-11-07" version="1">MATEENEIKDERLQHQEEAGDDEEEIAAMKKRVAEMESEAAKLREMQATLDQQSENLREDKEEIDARSVFVGNVDYGASPEEIQAHFQSCGSINRVTILLDKFTGQPKGYAYVEFAEPSLVAQALVLNESVFRGRNLKVVPKRTNLPGMSRGRGRGGFRGGGRGYRGGFAPRGGYRGGYRGRGRGYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1G0</accession>
    <name>A0A370Q1G0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_207466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1G0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="83348" checksum="82AE3D507910C567" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1G5</accession>
    <name>A0A370Q1G5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_288710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1G5"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="494"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="827" mass="93503" checksum="B6AC6B7E495B503F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1K8</accession>
    <name>A0A370Q1K8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_272456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370Q1K8"/>
    <dbReference type="Proteomes" id="UP000254937">
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="392" mass="43180" checksum="469C0D3C33C08254" modified="2018-11-07" version="1">MSEEDKTTPNKLSTGPLSPKPESPTTARPLDFDDEPQETGVTAAPSTAPAQQGAAEAAPPKPPRPLSPRQEAENTLKEAFPSIEASVIKAVLVASNWDVERSFHALLSMTDPSAVEQDAPPPKPPRPTAAQRQLEADEMYARQLAEHYNRPARQPRWDNEYPQQRPRRGSDGSEEKEYSFFDDDLPVIRENLRKGFLDTQTKVNSWVQNLKKRLDGETPEAGPSGQGQPDENYGRPRRSGDLGRRSGDRERYDADHRILNDDFSSLELRDAEAPPPRPPRPLANPDLFKTSSSSPDRRKVSFQEGPPTEIDNLYDASEPVRRTSPATGKSSKWQPLSTVDPSPVGEHDPFSLGDSDDEKEKEAKTKEQSTAEAGPASEASKDSSKAENAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3M1</accession>
    <name>A0A370P3M1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_280442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000017">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="47258" checksum="66339DBD355C3A63" modified="2018-11-07" version="1">MSSTSAQEIPEKAPDDSSKLKTFLSILRKFVGVADIASVRFSLPAHLLEPTPNLEYWNYLDRPEAFASIGQSEDPLGRTLEVLRFWFTKDLKYIKGKPCKPYNSTLGEFFRCTWEVDQTLPEVSPTPKAFSNAKDSSTDPVKICYLTEQTSHHPPVSAFFIDCPDTGVSARGFDQISAKFTGTSIRVAPGQHNLGIFVNLKNRDNEEYHLTHPAAHLGGLLRGALAISVSDTCYITCAKTRIKVILQYLEEGWIGRAQNKVEGVIFRYDPDKDVTTRIKDVPEGDVLARISGSWHGQVFYTLAGTNEPRLLIDVTPLFPVAKTLPPEESQLSNESRKFWSSVTEAIVDKKYGQATKLKQDIEERQRQKAAERQNKNETWQPRFFTGAVTPLGRPELTDEGLKVLDGLRSGDYRLDESLTKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3N2</accession>
    <name>A0A370P3N2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_280474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3N2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016737319" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12834" checksum="A2EA48518E1D3CC0" modified="2018-11-07" version="1">MPRGFATSLFSLLRTVLLGVAAQPGWPLSHSGILEFMDRHHHSLGEIKPVIPLPRHFTCVLSRRHRRHYLFSSQISFCALVCSPVTSRSPKASHPHVQGYSGSTFRLSYRPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P406</accession>
    <name>A0A370P406_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPD-GlcNAc transporter (Mnn2-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_340320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P406"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="467" mass="50511" checksum="41BB22E42F5E9AA9" modified="2018-11-07" version="1">MSARKFSVHDRNPLSTQTESKPNADYKLKTTITSGNGITNVGSEKVLKRAKRNDEVMGSTGATSGHLTSVLSATTHTVLPQWTNIILMSSLIFGGCCANVFALEAIIKDQPSSGPLITFAQFLLTAVFTVPGFLSVSAGPRSLYLSPRAIPLRSWIVYTAFFVTVNLLNNWAFAYKISVPLHIILRSGGPVASMIIGYLFNAKRYSRGQILAVLLLTLGVVTAALADAKAKGQSMNVESTSATTTLVGFTILALAMILSAFQGIYADRLYEKYGRDHWKEALFYSHTLSLPLFLPAYAQLASQWRTLFPTYPLTSGPEVLGMTGMGPPSHASSAGLESISSSEESCEGWHFASIFRSLSGQNPILKDTFQLHSIFTCVPTRVIYLLINALTQYLCIRGVHLLSAKSSSLTVTVVLNIRKLVSLLLSIYLFGNALSPGVLMGALFVFIGGALYGFEGARPRVKSAKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P448</accession>
    <name>A0A370P448_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_225934</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P448"/>
    <dbReference type="SMR" id="A0A370P448"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016935187" description="Glucoamylase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="533"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="640" mass="68309" checksum="26F58DD18AD7F702" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P475</accession>
    <name>A0A370P475_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_225847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P475"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="384" mass="41601" checksum="7CE05E6AA2D49F4A" modified="2018-11-07" version="1" fragment="single">PFSRSQAGSTASRVIVKKEPPSSPAMQSHTRPRPRRLDLSSSLPNSGGLSARPPGGPMTAREGVNMQEVGIACLSPGFQTHDPVMREQLQRSLSVRDQQRSIIESRLQKSAKDDGPDGIKPSESFGLPRVGASKRRPPPGLSIVPPSAAQFASERVIQSAPLNQTFTGRNEAQPLTRHVVNQSPTLGSTSHIHHLPATQTTNRLPPLSDVFGNEALGRDREANRGMYYPSATAANPPQSNNLPPIPSPRISRDAAQPPKRPREYRSAEEAVQELSGGREELLPRIVHYGGHQPPTPPSPRVANGPPKSGGTARRRSRNEYEHEHGSPPLGHGPDPHYRPNPALASGASATYGPFGAGRDSPETQRRKKEEFLSLCARAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6V3</accession>
    <name>A0A370P6V3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_92142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6V3"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="38815" checksum="ADA9F0748A3BD0F7" modified="2018-11-07" version="1">MAPASTSHRQTHNLLLISKLLSLRDTASPLTLVLDSLEQPATPLTKEYIRRAKLSRTHVTLLAFETLKPPEGVDAFIPARRKSPLEILKAVGAAYQNVSSNSPTRRRLILIDAINPLLHSKKNDPQFHVSQFLSSFLIPPNPTAPKVEVSLVVNFHQDVPSPPALSPYAPSPLSMLTYLATTIITLHSFSHILAQKAARDRSLAAPVFGLEEEQDGVLLGRLDRPSGQDSSEGIVLELEHRRKSGRGVLEWYFLPPASRYPPQYVKEIVTLLDDHPLYRPPQEPDAGAGEEEPESTFELRLTERQRREREGVVLPYFDAQQGDGPGEGGRILYDMGEEDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Q3</accession>
    <name>A0A370P7Q3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_257608</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Q3"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK38206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="410" mass="47932" checksum="7DB3EB971AC96E24" modified="2018-11-07" version="1">MWRLLGRSSNTPEKSSPPRSLPASWYRSDAMYQLERRAIFSKRWMLLTHSSRLTKPGDFLSFTISNFSFFLTRDREGSINGFHNICRHRAYPVVQARSGTTSILSCKYHGWSYGLKGNLSKAPRFETVSSFDKSQHGLLPIHVHVDKAGFVWVNLEAGDPEVKWEDDFQKIDEQPRMQDFDFDGEYTFDHYWEMDVEANWKLLIENYNECYHCATSHPLINGVSDLPRYRVEPKARYMEHHIFNKDNIDAQFRRSITYFYPTTSVTVTDKFFYIQRMIPVSATMSKIENEVYRHRDATDEEFANINAFYRQVLDEDRDLCVGAQENLSAGVFINGELHPDKEKGPIHFQDHVKTMVMEHRRKEEEQGGEEIWPAVPKVTKEMRTGKLAEEERFCSQLEAASCMARSELAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7T3</accession>
    <name>A0A370P7T3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">APH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_222920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7T3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="41309" checksum="0098AB1EE333A0AB" modified="2018-11-07" version="1">MADQAGQPIDIHALEKYLTQALPQIRPPFHVQQFQVGQSNPTYKITDSGGIAYVLRKKPPGKLLSRTVHQIEREYRALSAFQGTEVPVPKTYCLYEKDDVLGTPFYVMQFLDGRIFTDFTMPGVSPTERTALWRDAVRVLGKIHTTNPHSVGLQSFGKQSGYYDRQLSTFTYLSREQGKVEDPLTKVPVGELPHYTEMVDFFCRHEPRPKDRPTIVHGDYKIDNLIFHPTESRVIGVLDWEMATMGHPLSDFCNLTHPYFWDGLNQDVAMFRSGKVAGLPSRAQCLQWYVETAGWDPEPDLWWGDAFFAFRTIVILQSVAARHAERQTSSPDSVKYALKVEPSADAAWELVRKAKLKSKCGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8A7</accession>
    <name>A0A370P8A7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_297380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8A7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="39818" checksum="41CD144CB417C0FF" modified="2018-11-07" version="1">MGFTVDRSKFDSVLAELVADVLEHFASNGAPQEVMNYVEKCFYENSTNGKMLRGLSVPQTGLSILGRPVTEQEYHDLCVLGWLVELLQAYLLTHDDIMDNSSTRRGKPCWYRLPSVGMKAVNDGSLLRSSIFFLLKQHFQTHPAYLRMMETFQEVAFLCEIGQECDGIASEQRNIENWTMAEYEKLCNLKAGYYTFYLSVSIALQYFQLDASLNVQQIQDILIPLGSFYQSQNDYLDIFGNHRLTGKIGTDIQENKCSWVIIQALKMCSTEQRHVLLENYGQSSHDSALKCQRIFEALPLRELYGSEEDRVLNKLEDKIDRLDDSEGLRGGIFDVLLGCVRGVTKQARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8C2</accession>
    <name>A0A370P8C2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_279026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8C2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="369" mass="40179" checksum="4410A274A3E8863C" modified="2018-11-07" version="1">MILGTVCSLAGIFCLGLCTGTVLLTCPQAHAANSHYFPFLPEYYQFILSLSILNGIGSSFLFTPAMGTISHWFNAKRGLASGFAFTGSGLGGVIFPLMLQSLIPRLGWGWSMRLVGFVLLFLCILSVVLCRSRLPPKRGATSSWRDVLPSAAIFRDGTGAMAITSAGVFLVEWAYFVPITYLPTYYLTRKGLSGRQAIVDSDAAFAYQLLAILNSVSCLGRFFIGYIADRIGRYNTMIVSTLLCLVSVMCLWLPDAMADSPPNLALIIAFVILFGFASGSNISLTPVCVGQLCGTQDYGRYYASAYTLVSFGCLTGIPIAGSLMKATDDSGRKSFWGVILFTGMSYIASFACFLWVRVRIKGWNWEVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8F4</accession>
    <name>A0A370P8F4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_339009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8F4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48205" checksum="8B2E2B0D0415C5DF" modified="2018-11-07" version="1">MSQSLQDESQTNPTTPLHLHAELLPNIRQLTLYISVPPNTPRSNLQITLSDSRRAVTVTSSLSNTNQDDPTSTSETIKLPARVSESSRRILQQRPPSTQGESEYSFRMQVDDNDTSLHKEETTLNDGFIPWTATDMSAHTRLRCVKCHTPIMEGGKVWKDLPSGNWAEMMDFWHCHKPDPPEGERNKEGEDPNAVVKGYGAGNQLVAVEGTVLVDVTSFLVKGVDCLGVEESKVPPKDSTSTQPDTNTEPTILTCTTCTTQLGLPDPIANGYRLFKTSLSANTTSSSDDNNPPEETWESHPPETILTAQLLELIERESYRRFVIHCGAKDGLLIWPFNPSLRYSTTSASHSTAPQLAMKVFYQHVDNVEEILHPEVGKGNQSLAVEEVRLPGEQAYRELVEVLEERNAMLPASARVFREWRVGLLWRFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8M0</accession>
    <name>A0A370P8M0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_297308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8M0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="40998" checksum="FDD3A7DE46B577A4" modified="2018-11-07" version="1">MPDNTQLLEFIAQKRFHQRIVLPATTEHGRLAVTYADIGPQTKKDGSPTPTMLLIQGMAGSRLWCCQKDHLANKLGVRMLSIDRPGIGGSTPVPPEKRVKVWLETVSAVLEHLSIKHVVPISHSAGTIYLLNLLSHRRDLLWPKMPLAVLMAPWVEPKHSDILSLQMAKMLPTSVLKQWNKVMKFVVTKAAPSLSSSVDILSSMGGSIPRGSTEDINHCEPNLTADEIGPRTAKQLENLCIEYIFLEDTTGMNDEAVVCLKKTAGLWEACEDLPIYIRWLVQAEEWYKQGHPEEQKPLQLKAIFAEKDGMIGPQGQKYFENCFAPINLNNVVSFQSVMEKGTGHDTLWASETGAFLKVLEDIKDAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8R7</accession>
    <name>A0A370P8R7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_76152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8R7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="289"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116779" checksum="903063294F5625D3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P928</accession>
    <name>A0A370P928_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_257027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P928"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="58"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="39789" checksum="2526A5018C5A5F52" modified="2018-11-07" version="1">MAETDAPFETLSDDNHGPLITLVSVAFLIVAIIFVSAKLCSVLYFKQRRSAVHTPVWLALALLIVEVVVIQKGVDNGIGRHIDTLSDTDIQTASKYLYAAQLLHVVVLSLSEISTTLLVWKLTPHRGIRQTCRITVGVVAAWTIFSIFGIAFQCQMPNSWLYTASRCAGQGSILYPISIIHIITELVIVVIPFFMMRNVQLTLTTRVKILAAFSARIIVIALAIAHLALLPSYLHSTDITWTITNPTICQQAMTCSTVTIVCLPTLYHIFAGLHSGLITTRLPDEVELKHNYPYGQNSTLGSHESKGKRPTELATIDSVVTAKRKSTIKRSSLSDSTKRLTDGDKGGGVLMTVDITVEVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P936</accession>
    <name>A0A370P936_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_221850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P936"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF86">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G07000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="287" mass="31324" checksum="63C753242CF732CB" modified="2018-11-07" version="1">MSSFGYLCHFQTDNGDEFFANSSSTSPVIGSSVTAYPTYEELVQGQSSTTATIAKLLPPLPPTNNSIYCVGLNYRSHAKEANLNVPANPPVWTKPPAALASPDETIPISRFCASHLPDWEAKLVFVTSRECRDITPEQASQYILGYTVGNDLSCRFFQLPEQSGGQFFYAKAFDKFAPIGPVLVSPDMFAQTRASATLVTRVNGEVKQDTVIGKDMIFSPERILSWMSQSTTIPAYTVVMTGTPAGVGVFQKPRQLLKDGDQIEVEISGLGTLKNVVRFEEGQDSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9D1</accession>
    <name>A0A370P9D1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_73879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9D1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017018672" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55354" checksum="98BD92FFE1924F7C" modified="2018-11-07" version="1">MARRFFAACSALLLATQAAADNFPYNSYRTAPYTPPQIKVTKSGQTDPGYIFVGPRGNQPQGTAALIYDEDGQLVYEGPEEVTANFKVQKLFNEDVITFWAGNMMDLGFGYGTVHILDNTYREIYTVTLQDNFVSPDGTPRDSYIDLHESHVTDRNTLLVTAYNVTQHDLSSIGGKPDDYMLDGMFFEIDIATNEIVYQWSALDHLQDIPLEASKQGLGADQGTQDKPWDAYHINSVELMNEGYIISLRHYWSGFYVHNNGTVMWQLSGERNAGDFEIDDGAIFSWQHDIRVYHQTEDSMEISLFNNANTPTDTVDATTGLNLHVDLTNRKVSTLRTLKDSSDVIHSVSQGSYQLLSEETSHVVLGYGSIAKVKEYDAHNNEVMTAQFGDDNAVASYRGYKCQWKATPFWQPAVAIVRTTSDAATLFMSWNGATEYDNWAIYTASSADAVDPTFVTSIKRNGFETTAHVTGLRTNWLQVVARKGNVPLGTSAMAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9F3</accession>
    <name>A0A370P9F3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_239803</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
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    <sequence length="1403" mass="154242" checksum="431982618416A379" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAC5</accession>
    <name>A0A370PAC5_ASPPH</name>
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        <submittedName>
            <fullName evidence="3">tRNA a64-2'-o-ribosylphosphate transferase</fullName>
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        <name evidence="3" type="ORF">M752DRAFT_278589</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
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                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="460" mass="51190" checksum="78E141E3E8F7FAC4" modified="2018-11-07" version="1">MGSASASDPYPVSVSSLHFPSAEQQSISQTLSALRRSALSVTNRLRSIEADAAFVREVAAHYHLPLIANERCGSWYIPPEVKSGSAYFKSTDGHTGQWDFSFRRLNLQLLPIAREHGGCIIVDSTRRGKLMPDALSKTVPIWCAVINRALFPSDTAYHAVNFPPNYLGASEESQIERRIDGFVKSLENLKLDLDELKQQLGKPIRVAWANRAYFHPTDLHKGNDYRLFVLCSASKRVHGAEMSEGGYIQGAGDDSESWAYGLTPPVFWATKATLFQYSEEDLPTVIEQLVEDHSKKNVDQRAIRVAPTRNLYISQTHPQLNNGSMFNLVIDCNASPEGAEDNANRLNLGCGSSKLGSRDLRKHLDKVQDFVKSRLSSDPSQSLLVTCETGKDLSVGALLAILCLFYNEEGEFNAIPTNQLIGKQFIRQRLAWITSSKHDVNPSRSTLQSVNAFLMQRPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAS2</accession>
    <name>A0A370PAS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951916" evidence="2">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="59434" checksum="0960A17C7EADA9DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBH4</accession>
    <name>A0A370PBH4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CNH domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_49938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1464"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1836" mass="201921" checksum="2102279CC91B99F4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBL0</accession>
    <name>A0A370PBL0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_337930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBL0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12058" checksum="D96BDA0B1CAF9CD4" modified="2018-11-07" version="1">MPTPESASFLAKKPTVPPTYDGVDFEDNVAVHNARDAIIREQWVRSMMSRLVGEELGKCYAREGVNHLEKCGVLREKYFELLGERKIKGYLFQEKNYFAGEGNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBZ8</accession>
    <name>A0A370PBZ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_304945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629230" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="332" mass="34856" checksum="7008C6F02377D1D6" modified="2018-11-07" version="1">MKIHPSLLGTLALSASTLVSAELNVRTIYQFASNDTWLENLAVRSNGLILATEIGPPASLLSFDPRSSSPKKNVIHTFPSVLGLSGITEAAHDVFYVTGANTTSDNISDPPKNATHIWRVDFTANSDTPDIKLIARPTAPTGFNGLAAFNETIILASASYQDSIFAVDTTTGRTWEAIKDANLMSSINGIKVQDGFVYWTAGGDFCRAKLYSNVTAGPGEVIAEAIAFDDFAVSPDGFRAGSGRKFAYAATAAENTIMQISFDLQGGRNLTSVIAGSLDSTEIAEPTGCAFGRGEGEMDWLYVTTGGGSGVGVDVDGVEVAVGAQLLGIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCA6</accession>
    <name>A0A370PCA6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_278243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="65465" checksum="C548F88C96548C6D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCB8</accession>
    <name>A0A370PCB8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-methylsalicylic acid synthase</fullName>
            <ecNumber evidence="5">2.3.1.165</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_304212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.165" evidence="5"/>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050641">
        <property type="term" value="F:6-methylsalicylic acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="51"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="956"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1711"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="956"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1787" mass="191772" checksum="565FAE3D5AAE4D50" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCS2</accession>
    <name>A0A370PCS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_328603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="37809" checksum="3046A324F1FD59B3" modified="2018-11-07" version="1">MAPQKVFLTGVTGYIGGDTFYDVYQAHPDWQYSVLVRNKDKAAQVTSKYPNVRIVLGDLDSADIIEEEVKNADIVLHCADCDHVAAAEAIAKGATHHTPDRPVWWIHTSGTGILTVEDFRSNTWGLERAKQHDDWDGVDELLNLPADSFHRNVDEIVINAGKRAPDSVKIAIVCPPTIYGPGRGPCNQKSVQAYWLASAVLKRKKGLQVGEGKNIWHQIHVQDLSDLYLLLSEAAAAGGGKATWNDKGYYLAENGPFCWGDIQKQVAQVAYEKKLIPSPEVEPLTDEQVTETNQFGLYAWGSSSRGTSYRGRKLLGWNPHRPSLKELIPEIVDIEAKALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD14</accession>
    <name>A0A370PD14_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">M752DRAFT_255088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="247" mass="26608" checksum="610AD240A30BD348" modified="2018-11-07" version="1">MAVRAQFENSNEVGVFSRLTNSYAIVAIGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNRNGLLVPTTTTDQELQHLRNTLPESVKIQRIEERLSALGNVICCNDHVALIHPDLERETEEIIADVLGVEVFRQTVADNVLTGSYMALSNQGGIVHPKTSIRDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWLAVTGLDTTATELSVIESVFRLGEMGPRGVGMGDANKESIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD22</accession>
    <name>A0A370PD22_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_295927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="846" mass="91812" checksum="8DA5165B79BA7D0B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDG5</accession>
    <name>A0A370PDG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_320218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24983" checksum="8CF755091A49D79B" modified="2018-11-07" version="1">MPPPEYVYPRDYLDNNRIVLTDLSRRLPPSVQLDAFDSSLAAFPPKQFLPRNIGLHQWDMKTDIPKELEGVYDIVHVRNVVSVLSDEEVEDILKPGGYIQWGEINEECSTSALEELVRITRSALPRLVPHWVPVLPQLFESTGLVDVKKDTREGLGYMDYMLHECVLMAHDIIVRNTNNKEVGQRLQGILSEVLKETYDGAFHVWTKLTVVGRKPEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDH6</accession>
    <name>A0A370PDH6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_285081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDH6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37531" checksum="5418AB039FF2BE06" modified="2018-11-07" version="1">MDPKNQVYPSFNELPLQKDGPAGNAWGLWGPDDQLGCLNHLTDDVVARAAREEIRTGSRISLNWALNASSYPTLTRKNLELKLINKAPLKIAHDDEWSFNPQCSSQWDGFRHYAYQKEELYYMGRTAEEFRESTNPNGVQHIAERGIGGRGILIDWYRWYQANGHTVDAMSPHPVPFDQLIEVLRYQGLTDKDIRPGDILLIRFGYINQYENMRGDKRARLDALYKKQKPENIGIEPSEALLRFLWEKKVSAVAGDTRSFEVWPCTQAQWHLHEWLLAGWGMPIGELFDLEKLSKACSEAERYTFFFTSAPMNAPGAVSSPPNAFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDY3</accession>
    <name>A0A370PDY3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent leukotriene B4 12-hydroxydehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_254455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="38624" checksum="7ED9ACD8D4C03161" modified="2018-11-07" version="1">MTITNRQLIYVKAPTAAIDPSVTTGTFNLKSTTIASKDNVPDDKVLVRIHYLALEPAMRQWLTAKRSYIAPVKIGSIMRGQSIAQVLSVGSSLKSQYKVGDWVIAYSGWQEYAFLGAKEAQKISVPAGCKPTDAMSVLGMTGLTAYFGMMDVGKPKAGDTVVVSGAAGATGMVAGQIAKIQGAKRVIGIAGSKDKCEFLCRELGFDVAINYKDEDWKKQLKEATPEYIDVYFDNVGGEILDACLGRAAQFSRFVICGAISQYNVAKPKGPANIMQVISQRVKMQGYIVFDYAKQYPDALQDLAKWLTQGKIKRKEHIVKGGLESAPQSLVDLYKGVNTGKMMVEVVPAEEGIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEA7</accession>
    <name>A0A370PEA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin fusion degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_253558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="4">
        <location>
            <begin position="168"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="3">
        <location>
            <begin position="270"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="2">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="756" mass="83010" checksum="FC691E9484F30617" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEY7</accession>
    <name>A0A370PEY7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEY7"/>
    <dbReference type="SMR" id="A0A370PEY7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="41537" checksum="E337FDCA2B73A667" modified="2018-11-07" version="1">MPGHFGQKILNTLGIDHHGHHGHGQGQPYQQPPPPGDNRLAGNRVIHNDERLLSPHPAGTYPRLARLHDGRILASFTRFVGDGERVLMVSISEDNGQTFVDHGEITRGKGDVDNVYLLEIGPGTVLAAFRNHDIGPGGPTHFRITVCRSTDAGRSWSFASQAAEKPAPLGIWEPFMRLGRRPGEIQLTYSQEFAHNNQCTMLVRSYDGGSSWSAPHCLHGAEDQRRDGMNGIARTWDQARNCEALVMVFETTTYGTFDVEALVSYDDGETWGGRQQVYVPPQGHNAGAPQIASLGDGSLAVIFMCDEDFGEVNWTRNACVKVVFGSMPHEGRIMWTRPTTVCADSSHWPGIFTLDDRRLLALYECGGPKAKTIALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEZ8</accession>
    <name>A0A370PEZ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEZ8"/>
    <dbReference type="SMR" id="A0A370PEZ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="209" mass="22698" checksum="9D3A7E0262792982" modified="2018-11-07" version="1">MRLPYAPSTPPDPTDLPTTEIYSRIAARRHPRPLIPLDLSLLHSPPVADGWNSFLGAIRTQTIIDGGLLELAVCRVAVLTNAIYEWNAHAPLALKGGIKGAELGAVRTLPSLAEGDAKADEELEGSQLTSVQKAVVRYVDEMTRTVKVQDSTFEKLKEVGLSDREIVELTTGVAGYNCVSRVLVALDVGENNAKEMRSVEDLVADLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF05</accession>
    <name>A0A370PF05_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF05"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="41496" checksum="D165E4F7A9924A0C" modified="2018-11-07" version="1">MASTSPPAVRSKIDLLITNLVNIQDKTGQFLLPLADGRIIDTKSWHGWEWTHGIGLYGIWKYYEMTGSPHLLQIIEDWFAARFAEGGTTKNINTMAVFLTLAYVYEKTQNPVYLPWLDAWAEWAMHELPRTKQGGMQHATYLTENYQQLWDDTLMMTVMPLAKIGKLLNRPDYVEEAKRQTLVHVKYLVDTSTGLWFHGWTFEDGGHNFARARWARGNSWVTMVIPEFVELLDLKEGDPIRLFLLDTLEAQCEALMGLQEESGFWHTLLDHPDSYVEASATAGFAYGILKAVRKRYLPKKYRVVAEKAVQAVLSAVDETGELQQTSFGTGMGDSLDFYKKIPLTAMPYGQAMAIMALGEYLRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFC5</accession>
    <name>A0A370PFC5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_328247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="7">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="153" mass="16446" checksum="B5AC53DC95F634CC" modified="2018-11-07" version="1">MAEKANPPAVPAYEEQPAETHELSSSREVPAYTQPPAGQTPEIQPHQPQQTFYAGSQHPSGYNTPTPLYALQKTPAPVDCPACGERKMTRVEAETGSSTHAWAAVLCCCLCLGCIPYMMSSLKNQCHYCGGCGALLATWHNSGRTDVHRSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG58</accession>
    <name>A0A370PG58_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_217765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG58"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="322" mass="36149" checksum="A2E1C55B051F6D20" modified="2018-11-07" version="1" fragment="single">NKIASIKPRKVNELETQIRGFQAANLKLSDEKQQLEEKIQGLAGSLRESEGQVKALHKIIINSGLESPGPLDDDVVLSFDQLFFRIRQFVGKYCRGCELRDGAYQRLSLANKNLWLTATIADRLYSQLFLPNVSLFGFTAEWDSCLGHLEEELSHGRNVPAADIRKWRASTLKLAQLHDPELKYACTALNEMCGNISSEIFQDEWRNEDNPDTRYQEIQAAMADICKQAYRLAFLLRQSKVDYTWLQAKDPGSLTTDETEVVGSEGGKGLETSAKIIFGGALKGPGPYLALKWQVIYVNDLLLGRCERDGPFPTSRSQVCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGE8</accession>
    <name>A0A370PGE8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_253477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGE8"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="50953" checksum="95E5937A5D8143E4" modified="2018-11-07" version="1">MQSISPVYSSATDRRYSPPWADLSIIGIAGSSGSGKTSVAMEIVKSLNLPWVVILVMDSFYKSLSPEDHARAHRNQYDFDCPESLDFDVLVQTLRDLKQGKKADIPIYSFAEHQRQPETSTLYSPRVLILEGILALHDPRIMELLDVKIFVEADMDVCLGRRIMRDVRERGRDVEGIVKQWFTYVKPSYKQYVEPQRAVSDIIIPRGIENRTAIEMVVQHIQRKLDEKSEKHNAELNRLGLIASEEQLSSNVLMMPQTPQFVGMNTILQDPATEQVDFVFYFDRLAALLIEKALDMTSYVSQAVDTPQSTSYDGLNQAGVVSAVAILRGGSCLETALKRTIPDCITGRVLIQTNEKNEEPELHYLKLPPNIENHENVMLLDPQMSSGGAALMAVRVMIDHGVQEDKIIFVTCAAGKIGLKRLTTVFPGIKVIVGRIEEEREPRWIEKRYFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGH3</accession>
    <name>A0A370PGH3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_217223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="12">
        <location>
            <begin position="635"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK41300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="965" mass="105839" checksum="ECF5459A5CF547AF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGL6</accession>
    <name>A0A370PGL6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_277114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGL6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="249" mass="26347" checksum="DBF7C6B15DD0AB6B" modified="2018-11-07" version="1">MIFAATPPWDGTLAKYHVNASDFCYKVPDHMSMEEAAMVEPVSVAVAIAKTADPRAHQTVLVLGCGPIGVLCQAMAKAAGAKTVIGVDVVQSRLAVAESYGVDHVFMPERPAPDDDPMAQAEKMAVKLKEECGLDEGTDVVLECSGAEACVQMGIFAARHGGTIVQAGIGKETVNFPIAAVCTRGLALKGSIRYLTGCYPAAIDLIGKGIIDVKRLVTNRFEFEEVEQAFESAKSGRQDVFKVMIAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH08</accession>
    <name>A0A370PH08_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_27646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH08"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000099">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="147"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="535" mass="58113" checksum="83CB2340E633AD23" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH44</accession>
    <name>A0A370PH44_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH44"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016909965" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="121" mass="12875" checksum="A3D6CE77F862F81E" modified="2018-11-07" version="1">MKFILPAVLFLASAVSAQNVVLDYSDGIPLCCTTHDLVSEAEDEVIQQVTSAFESDGGGAWDLGEAIAGECQTAFPTGFAGGNRTDCPEDLTAIWCKKHAPWTLTINGTSTPRDAHGQCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHD0</accession>
    <name>A0A370PHD0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_302066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHD0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72133" checksum="3646372DA1AF3B5D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHI4</accession>
    <name>A0A370PHI4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_276997</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHI4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="24">
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            <begin position="740"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="968" mass="106804" checksum="8B92F1272D0D1387" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHR3</accession>
    <name>A0A370PHR3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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            <end position="246"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="323" mass="34289" checksum="DCDC3CEEE90DBA59" modified="2018-11-07" version="1">MVSTVERPAHIQFARNGTRGRHVSSRSPTSGLTIEDALAPITSTAAKTRKKRQIATFIYAGLLAASLVADILALLFLTRPSVQQAGVATLHLNGEGLLSKRGKKAYTMGETYVTASSARIDDNTAEITTAASNVPLLTATRAPDRPGFLTSDTNGSDWISIGTQALCFQSGPSSRVCHPLPANLSIILPPPMQLVLGDSVSQLQDFERSAAVTARRGARSVMAIGLLLISVAVTLLLIFSWWSWAYVHRVKWLMMAVASLCGLVCFTVSSGVLGTLQSSIEEAVHRGIPGIARMEWGSANRYSLGAMCCAIVAFGCSLASQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI02</accession>
    <name>A0A370PI02_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_327179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI02"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="816" mass="88864" checksum="A32144E80AFC28B4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIP3</accession>
    <name>A0A370PIP3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_266716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIP3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="202" mass="20869" checksum="2592013B54244C0C" modified="2018-11-07" version="1">MSNIWDSITGRKQSKVSEATASAPDATSFLSDLPDPSQLHPLAGLNQDTLDYITLEDSALDQTPGSRSVLPSRGWSDDLCYGTGTTYLAGLTLGGAWGLAEGLKKTPVTAPPKIRLNGALNSITRRGPFLGNSAGVVAMVYNGFNSGLGYARGKHDAANSIVAGALSGMVFKSTRGLKPMVISGGIVACIAGGWTVLSKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIV3</accession>
    <name>A0A370PIV3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_294097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIV3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="210" mass="23369" checksum="A48BB42E964B5570" modified="2018-11-07" version="1">MRFLCLHGIGSNSRVFEQQTAALRYELGERHSFDFLEGTLPWEASVESIIETGEATFAYCDPHQPQSCLQAMNDLERYIRVKGPYDGVMAFSMGTCLALTILVDHALKGGTQEPPFKVAILFSNPEKPFNMESLRQGRIEPWNPRPIISIPTAHIWGSTDYLGHNASLAPQYYRKKSEAIFVHKGGHKVPTSAEDVVQIANVIHRAIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJN4</accession>
    <name>A0A370PJN4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJN4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="39703" checksum="50DB2C962492C1CB" modified="2018-11-07" version="1">MHLDHKIPWNTAATHLNLIKCNPRFTPRRTDFFARNKPTESSDLNYFRRILTKTIREFSCTEESKLLDPVPLENLLSDNLLCYSEHQFDLGSHRTNSALHNPLSTKHRDIQYWINRASSSDDNYPISYSSADGDLADAVKMLIIIAASGKKHDSTSKQISKEAISVLLTLSRHPQIPLHTLAGIHWGHAFGVELVAETALGVYIMINLMDLLLINKQLKKDEVASLLETQTFQYWARHALADYDFPMQNIPHRRFWNHFGVTDMCASQQQCEEVVSVSVEDGGMTDPLKGESEDVRLRLQDYLKACFAILYIYDMLLREWYGEEEADEKWGYWIGCLFESWGCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJU5</accession>
    <name>A0A370PJU5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_283817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="777" mass="86405" checksum="7A90C474C84AEAA4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK82</accession>
    <name>A0A370PK82_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_266401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK82"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="353" mass="39182" checksum="A802977BC7AC7D58" modified="2018-11-07" version="1">MESVQLSHSGSTTHSSSIPGMFSPDRSSHVNTSGSIADDQPRRAPNREERFTSWVADHRLDLEQRILGDRAERRESRLPGRPAPSHSSLRDAAASQYAPRGPYVPIELQSAAAGSSGEARSHARSERESHSAHSPPDPEDLRCRQSQSFVSRLKEKRLRRRLITLVISACFLILVIAIYLAFAASRTTLGRELQILLIFMILILGIVFCHSLTRFLMALLRRPDSDVATNRIPSRAGPAGYAQPARPIHVILAGDEDVGAASPNAVREKVTAPPPAYGLWRESVRINPDLLYWQRIENNNAHVPKGVGRHGSNKSRIPRPPSYTSDNGVDYVIEAQPRSFTQWRIPEESGHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKD9</accession>
    <name>A0A370PKD9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_234371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKD9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="509" mass="55187" checksum="DAADDFAA21709111" modified="2018-11-07" version="1">MPSEDSATPVQSNTSTGVATPEPPYSIFDKRQKWLIIIIVSTAATFSGFASNIYFPALPTIANDLNVSIELLNLTVTSYLIFQGLAPSLWGPVSDVKGRRTAYMCTFVVFLGACIGLAESKNYATLIILRCLQSTGSASTIAIGSGVISDITTRAERGGYMGIFQAGLLVPVAVGPVIGGGIAGSLGWKAIFWFLTIYSGAFLCFLIVFLPETLRSIVGNGSLKSSNPLVNFPLELYQKTTKVEWEQVPDGQSQRAAKKKIDVLGPLRILISNHAAPIIIFLAVYYAVWQMSITAMSSLFKSRYGLSEIQIGLTFIANGVGSMIGTLVTGKILDADYRRVKSRYEASLDAEQGEETTAATREENFPLEKARLRLVPIFSILQCLSIILFGWTINYARKVHIAVPIVSTFITGWTAVSTQSLIMTYLVDIFPDRSAAASASLNLARCLFAAGGTSFIMPLINSVGVGVAFTICVAVQLLALVGPLIQWRFAAGWRRKERERDAQRADVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKU4</accession>
    <name>A0A370PKU4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_214279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKU4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="437"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="828" mass="90658" checksum="F82E4BD64CB04A87" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKV7</accession>
    <name>A0A370PKV7_ASPPH</name>
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        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the EIF1AD family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="104" mass="11790" checksum="C798B90AFF5B4C40" modified="2018-11-07" version="1">MGPPRRKVLATAEETMFPPDELSQGHLIARAIKATGNNIYSVELPSKESVLVELPARFRSTIWIKRGSYVVIDTNALEGRDNKLKGEIVNIVRDEKAWRKAPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLN6</accession>
    <name>A0A370PLN6_ASPPH</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">M752DRAFT_233647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="8">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="436" mass="47199" checksum="8688B1BB6C634BBC" modified="2018-11-07" version="1">MEAPETTEGSVLVGAARRTLGICLLLVVVFLWTASNFLASTIFADDTYSKPFFVTYINTSIFILPLFTILFRRLVKLWRAGKLYRIRSFKSLLEHLDSHDTNVEARGILSHDASGEHWRSEDEDPETWAAARFDAASRGQQSKLGLKATAKLSFEFCLLWFSANYFAMACLQYTTVGSTTILTSTSGVWTLIFGALIGVERFTIRKLIGVIASLIGIILISRVDMSTPDNPSNNNNSSSSSGSGSTFPSKTPGEIALGDAMAAFSAILYGVYTIVLKKQVGDESRVNMQLFFGLVGLFNTVLLWPGFIILHVLGIETVGMPDTGRVWTIILVNALASLASDIAWAYAMLLTTPLVVTVGLSLTIPLSLVGQIVLQGQYASALYWAGATVVFLSFLVVNQESREVDGEGPVVVGRGGAGSGYEAIPGDRGNAYGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLT0</accession>
    <name>A0A370PLT0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M752DRAFT_213611</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLT0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDK43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="42350" checksum="E57CBD4E344EF3D0" modified="2018-11-07" version="1">MPGRTLPTFTPAEVESHNDANSCYVTLGSKVYDVTDFVAGHPGGEELVLEYAGKDVTEILRDPASHAHSDSAYEILDECLVGFVSSEPNGKAANGGVTQPKEQAVFATTGLSCEEDLSVETDYTKDYQTHKFLDLNKPLLVQLWNSGFTKDFYLDQIHRPRHYRGGESAPLFGNFLEPFSKTAWYVVPIMWLPPITYGTIVGFSGLANVPAAAAYWVGGLFLWTLIEYIMHRFLFHIDKWLPDNRVGLTLHFLLHGIHHYLPMDKYRLVMPPALFIVLATPFYKLAHTVFFYNWYAAVTVFCGGVFGYVCYDMTHYFLHHRNLPSYYKALKKYHLQHHFADFDNGFGVTSRFWDRVFGTELEMPSPKNVKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PME4</accession>
    <name>A0A370PME4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_318701</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PME4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="641"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="689" mass="77847" checksum="6386DE5C990A7D0A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PME8</accession>
    <name>A0A370PME8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_314521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PME8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="487" mass="52642" checksum="0489D85F74541FB0" modified="2018-11-07" version="1">MDRSCPMESIQSTQEARTKSSEDYNSADNGDYESNESVTNPKLSIDTDAAPDGGYGWVIVACVFWLQVHTWGINGSYGVFLSYYMDNNIYPGTSSLAYAFIGGVAIGCAYLMAPVTVFLIRRYGTHTTIISGIIIQTAGLILASFTTRVWQLFLTEGVCFGVGMGIIYMTYLGVPPQWFDKKSSVANAIPAAGAGTGGLIYSLGIEAMIENLGLPWTFRTLAIVSLVVNLVCAAFLRDRNKATASRHVAFNFPLLKKIEVLLLIGWAIFSTFGFVAINFSLPNFAISIGLTARQSSVVGALHNLGQGIGRPLIGLFSDRLGRLNVATALSLVCAVFCFAIWIPARSMAVCCLFAVMGGMVSGTFFATVAPVFVEVIGLQDLPGALSILWLVLVGPGAVGEAIAQALRRPAEGMEAYRQVQIFAGMVFVAAALCLWVVRGWKVQQQRRGAATHTAGMCKEMVEVEVRAEKSGWNVFELAREMVRYSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMG9</accession>
    <name>A0A370PMG9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_318708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="627" mass="68241" checksum="59D462AED2A62082" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMM2</accession>
    <name>A0A370PMM2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_275640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMM2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="228"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="481"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="657"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK43432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="729" mass="80700" checksum="84B820184180C291" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMM9</accession>
    <name>A0A370PMM9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_157181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMM9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="89" mass="10017" checksum="3906E705F0F051E6" modified="2018-11-07" version="1">MAPTRKKWSKGKVKDKAQHAVVLEKQVAERLNKDVQSYRLITVATLVDRLKINGSLARQCLADLEEKGQIKKVVGHSKMNVYTRAVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMQ2</accession>
    <name>A0A370PMQ2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_250206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMQ2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="135"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="985" mass="109294" checksum="5F3F3DFA2D346933" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMW6</accession>
    <name>A0A370PMW6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_335313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMW6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="572" mass="62234" checksum="C2C4DE76A4A51ED8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN97</accession>
    <name>A0A370PN97_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_325618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="39409" checksum="16FB006F1AE310A7" modified="2018-11-07" version="1">MSEQQPNGTTPKVTGLSERTRAKWAAASTPEEIAANLPPMLDLTIENITENVMKINSMCDNPRMRYLILKLIQAAHDYIRDVGLQFDEWEQAWQFLTRVGQISTDVRHEFVLLSDILGISALVDALSYPAVPGATESSVLGPFHDEEAHSFEYGESITAEGTPGEPTIVRGWIKDTEGNAVPKALIDVWETDGNGVYDLEYDGSEDPNCRGKIFSDERGHYLFSCVKPVAYPISNDGPVGELLRKLKRHWFRPAHMHFMVAHPEYTKLITALYSRDSNFVESDTVFGVKKSLIVDYNWCEDLELAKQHNVEPIVKTIDGRESKGFWLLERDFILVKKSPPPPRKTEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNN7</accession>
    <name>A0A370PNN7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_318372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000292">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487868" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="35"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="561" mass="61543" checksum="846C0545B41DA9AE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNP2</accession>
    <name>A0A370PNP2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_313723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNP2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="531" mass="61099" checksum="C2A7957B9051F142" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNS8</accession>
    <name>A0A370PNS8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_282773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="724" mass="79592" checksum="57A54AFCC646C5F6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP48</accession>
    <name>A0A370PP48_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016876387" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="8691" checksum="7BC3350E5A1FCC60" modified="2018-11-07" version="1">MRLSSIITFLSLAVLPATLASPIDNQESSIAKRCCILCDNPYARCGANDKREAVQTEEEVFHGQVKRCCVNCDVNRCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPI3</accession>
    <name>A0A370PPI3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPI3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="191" mass="20395" checksum="B2F23087F43FBB1B" modified="2018-11-07" version="1">MAQLNYRTINIDVLDPESSINFPMDTLLPPTLPAPTTSGAAASVVNQVRQLLRSGDNEGALRYVLETAPLGGDDRAKEVHLAAVVEVLQGIRQGEMSRVLEAVCTGEGGSERADCLMKYLYKGMAAPTPSNAAQSPRMSPQSTGFSQIQARNLGEGGGGQQMSVLLNWHEKLVEVAGTGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPS9</accession>
    <name>A0A370PPS9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_211430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPS9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480642" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="528" mass="58351" checksum="C60D54CDDCF3CF5F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPT4</accession>
    <name>A0A370PPT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_282355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="230"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="807"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119673" checksum="C43D3A169B9060EF" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPV9</accession>
    <name>A0A370PPV9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_274604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPV9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="217" mass="24900" checksum="58E1CAE9F48EFE42" modified="2018-11-07" version="1">MDLPPLSQEQLTAVVASAKTPTELYETLSDYESQACLLSMQKGKHAELLSLYYSTYFFSNLLIDKTIEARLTTQRMPQELLQNDSSLQNCLTLLRAVWQRKYEQVYKILRELPWPEALQPIVQSYESHFQEKTLKEVSRAYEAIRPTAAATYLGLDPAAAQQGDPAIMQKFIAYGWTWDQEKGLLHPKPIVDEVPQKDVRLYNELSEVMALIGNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ52</accession>
    <name>A0A370PQ52_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_138602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ52"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="110" mass="12221" checksum="0E011D5AA52124C7" modified="2018-11-07" version="1">MKDAMLAHRIILSSKPVLVGNTPYFFIRNNSLIQPQELLFPAFWRAKLMITMEIVSSWPMRDVALSRARMIGLAPVRAGGRYAALKLGNVRGCGRGVGGVPYVLYDIESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQN7</accession>
    <name>A0A370PQN7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET and MYND domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_334392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="481" mass="53530" checksum="203F7DF504FBC0B3" modified="2018-11-07" version="1">MNTKTTPQPAPGGLGRGLFASTDIAVGEEVLHIPVPFVAVLDTEHLGEVCSGCFGQRQLEEEGITLKGCRGCGIVKYCDKTCQAKDWKLGHSLECSIYQNLKPRVLPINARAVLRMVLRSELQKYSSEELDQFLQLGTHIKDIRDQSASQWERISLSSKAIRAYSGTDMSEEVISAMGAKLDLNSFNLTNAVYDRLGVYLHPYAAIFNHSCDHNAAVSFDGPNLHIKALRPIRKDEQIFITYIDVTDPYPIRQANLQSRYYFTCHCSKCTREAGSPAAITLHPAQQEAYKILQSLSTLENPIQTLLQALTTLQTFSLPKTTQPSISLHDELITALLAKQKYKSAFAHAAARYRAVDPIVYPLQGHPIRLLHAWVLARLAIHLSQGVEVQHTGGNEEIVLEKYESNFNLIIWSVLAKLVGMESMGGMGPGFWRLVKREFRAVRGEFVAAGLDPRGSRELEREIGREWGKVDGVVRDLGFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRK1</accession>
    <name>A0A370PRK1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysophospholipase</fullName>
            <ecNumber evidence="3 11">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_230234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016483487" description="Lysophospholipase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="51"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="640" mass="69271" checksum="578639AD42D86A99" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSJ7</accession>
    <name>A0A370PSJ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_334018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSJ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK45152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="216" mass="23636" checksum="A66305D4027908A8" modified="2018-11-07" version="1">MDMTSSTIDISMDSPSCKISMLWNWNTVDACFISESWHITSSCMFAGSCIGIVFLVICLELLRRMASEYDAFIIDRARLKADTGDDRPGVSSIDDTFAARRPTPWTPSGSLSALPPVPESPPESDPMPAAPASAAKQDQTQFIFRPSQGERIIRATLHVLQFAVAYFVMLLGMYYNGYIIICIFVGAFVGFLLFSSGKVVGDEIRNDATSVTKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSR2</accession>
    <name>A0A370PSR2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_230795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="293"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1801" mass="205981" checksum="DE3E8C813047F903" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU43</accession>
    <name>A0A370PU43_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_324545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU43"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="214" mass="23590" checksum="93EFAA56CCE3D6F1" modified="2018-11-07" version="1">MRFLCLHGAGTNAEIFEIQSGGITYDLAKYGHTFKYYNGCMEAEVEPQLKGLFTGPFYNHYPRDRAPGEYLAPAMKHVYDIIERDGPFDAVMGFSQGAALACAMIAHHAKMHQEPLFKVAVFICGAVPFDSTGNEIIPEPSAGDEYPVNIPTANIVGKQDELYPSSMRLSRLCDPSKMSFHDHGSKHMVPFDVKNTEAMVAVIEAAVQKALRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUD2</accession>
    <name>A0A370PUD2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_210147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111368" checksum="DD42129CFE485F44" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUG1</accession>
    <name>A0A370PUG1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_263419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUG1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="183" mass="20766" checksum="DC9A95A2372D1786" modified="2018-11-07" version="1">MATPPKHFEDITDAQDKPNPLSPPPLVTLPDLKGSAVSPTLWYRIHVLIFDLKNFGNTSSKKRLDKVTDPSYIGEPYFTIEEAEKIKQTIIDANGKTFSETLVEGLNERLKRRNKKRVQSDDFRVCAAHDLAPLMASALGIDLKQMEKDNDFARMVELKGLNLRGEIWSGLKKKSFSPKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUV1</accession>
    <name>A0A370PUV1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_262311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUV1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="29685" checksum="BD075D0FBFBF7C55" modified="2018-11-07" version="1">MHPAAVSFKLPTLPKASQKPDEDEEEYNEGLLAARESSDLATASLALGRLSSDKRHCTSTSSRLLKRIGLLSFYLVILLLALNGFYHLVRPYSGTVAQYIHWPGSLSQDDLSCSCGDSIAEALTRSCRYDTLSAAWLPPHCRDDELTARFDAAGPGDGGAWTYYADQSGNYTMTLAEIAQLPGNDTHEFFYMTYRWHVFHCSFYWRKLHRMVHGVEGAAKRIEYRSDSESHIDHCEGIFTLNYPLDAIATGSGVSLNADRIPNIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW3</accession>
    <name>A0A370PUW3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_309500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016563345" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="11137" checksum="E5CF3CEFFDEE1D9E" modified="2018-11-07" version="1">MHFRNFALAITLLTVGVQAAPTPGFIGIEKRNDAAPWTAKLDEVEKRSDAAPWTAKLDELDEVEKRSDAAPWTAKLDEVEKRSDAAPWTAKLDEVESEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUW5</accession>
    <name>A0A370PUW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rcd1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_209093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="31840" checksum="7DF4A46B188F6D3F" modified="2018-11-07" version="1">MDGGISDENRKVFIWVAELLDPSRREAALMELSKKREQVPELALVIWHSFGVMTALLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHNETRTLFLNAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSDVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDIGLAYICATYERFYAVGTVLSNMVTQLVEQQTVRLLKHVVRCFLRLSDNSRAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVSDGAPGVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV59</accession>
    <name>A0A370PV59_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_209078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="543" mass="61155" checksum="892DA3F7EAA1CFE8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVJ0</accession>
    <name>A0A370PVJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_98900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVJ0"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="28899" checksum="9E444606A6E57536" modified="2018-11-07" version="1">MAGSAPNLYSFPSNDALAQQLRPYVLRCQNSAISRHNTFRVAVSGGSLPKVLAQALLAPGNGSPEDTAQFSKWDIFFADERAVPLDHEDSNYRLLKEELLNKIPSELGAPTVHTIDADHVNDEDPQELADLYQEELMRSFAAKDSVKLPVFDLILLGCGPDGHTCSLFPGHELLREKDAWVAAISDSPKPPPKRITLTLPVVTHALNIAFVATGGGKKDIMKQIFDAEEGRDLPSTLVNQGGGEKVSWFTDNAAVEGVAFPRRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWH0</accession>
    <name>A0A370PWH0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_290031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWH0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="11305" checksum="6953D56A920515F7" modified="2018-11-07" version="1">MPSNFCKNQSSSSKSSGTALGLQSETENIRIKGVKTAPRNIVKAFVDRDQDVKLLRELSESLQALPGVKLQREQWKTDVFDDLGKEKSDFQENFATKNRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX70</accession>
    <name>A0A370PX70_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_272589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX70"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="502" mass="57571" checksum="B2DAC8CC1BB7A2F5" modified="2018-11-07" version="1">MTDLYPSLAQCAIVATAFKILLFPAYKSTDFEVHRNWLAITHSLPVKEWYYEKTSEWTLDYPPFFAAFEWVLSQAARYADPAMLIVNNLNHDSWQTIYFQRATVIVTELVLLFALSRFVKSVSQQNKHLAHIASLSIFLSPGLLIIDHIHFQYNGFLYGILILSIVLARKQSTLLYSGISFAVLLCLKHIYLYLALAYFVYLLRVYCLDPKSIFRPRFFNIIKLGVCVVGVFALAFGPFASWGQLLQLKDRLFPFSRGLCHAYWAPNVWAMYSFTDRILIQLAPRLGLPVNQDALVSVTRGLVGDTSFAVLPEVTKEHTFILTFLFQLLPLIKLWRNPEWETFVGAITLCGYASFLFGWHVHEKAVLLIIIPFSLIALKDRRYFSAFRPLAVAGHVSLFPLLFTAAEFPIKTVYTVLWLVLFLYVFDQVAPVSERRRIFVADRFSLLYLTIAIPLIIYCSLLHQLIFGLERLQFLPLMFMSSYSAVGVVGSWIGFMVVYFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXD8</accession>
    <name>A0A370PXD8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="244" mass="27327" checksum="951649E0AB323E10" modified="2018-11-07" version="1">MSYGKSLALSQNSFVRPPTPDVVEAQEQDEFGARRQKRQATVYDAVAGRVNHHGFLPSAPYPSKYRDTASSSTRPVRPEEVLFRRQHAPQRYEENDFYFAHEALPPSCPLPCSELLEAIHAYSADFYDHATIDGGRDDYQSMDETALIAMGILMEEMAKESLGETGDMVLVEGEEIPTDELPSVPQLGRNIGRKRANTGQSSTMASSGDELESVVAKKRRPKKRKLGRKMTSAAELDMEDDERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXG6</accession>
    <name>A0A370PXG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_227789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="678" mass="76130" checksum="0467DCE5242CA729" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXV0</accession>
    <name>A0A370PXV0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_227992</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXV0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000029">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK47016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="531" mass="57980" checksum="3A3383D93D83999F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY45</accession>
    <name>A0A370PY45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_281171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23612" checksum="E6C54B74B97115E7" modified="2018-11-07" version="1">MRLLNTYLSDTQDFVIQEFLDYELPPYAILSHTWGKEEVTYQEVNTASTKEKSGFEKITQCCSYQKAEICYAILENVQSKEEIAQILGDRATLRDQLSEYTGIPAGILSGEDNLETSSVAQRMSWAAKRQTSRIKDRAYSLIDIFNVHMPLIYREGKTAFIRLQKEIMRISDNQNLFAWTSSNDRGGLLATSPAAFANSHNIDYQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY59</accession>
    <name>A0A370PY59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_70242</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="66674" checksum="1B1577389F809C24" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYD2</accession>
    <name>A0A370PYD2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_332447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYD2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK47192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="480" mass="54948" checksum="44DFE71746E814B3" modified="2018-11-07" version="1">MVVDPEKTAVGEASEATPLLQKTAVLVSPQACQQHQLLLRCFSNLKQRTSKTAGLFKTEYDHEINSEVDPIARQSMMEERRWSIYVSRAVHRFSVWWALLPADPEIPGIESEKPYGHHGGWIWTRDQLPPLDVLMVLHALILHHKSFGEDCLRHKKMAQWNEGFPLQLASQCIDTDSLKYTCPESCKLNFESMTKLAWDNPDDAESVSIGCPRCQDQNVVPWTTRRRKGFADDSYQVCQSCKYVLGKNAFIVRKLRQDLHLLLDKGIPLPGTCWSVEDGHGTLTPNNAPNEFVKRYLMDTLLEETRPTNLFPDITQILELLGQTVVKQALPILHDIFEHYLYVENSSCDLSAAVRRMLKSATAAQDIILSETDFHSPQMQTQYVDYLRGQGKGFWSRSPDVSELNLMDPIMWVWSTHLLTARSYYEFFRRVGNGLPVDWQPPHSPKCRLCHTMRPPSLARRFFQGLVSLSAWKEFMEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYK8</accession>
    <name>A0A370PYK8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_306641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50391" checksum="B7C4F9FD8426C888" modified="2018-11-07" version="1">MSAAAMSKKNKGKKVADPNETSKLLAAKISQLEQDAAGEKDQEAEIEREVKKATRDLNQLLSNIESPMTRLETVHKKYTELLADMKKLDRDYSKSKKRADQLQKDQDKGKSELNKTVTMKDKLEKLCRELTKENKKVKDENKKLEETEKKARLIVNERLDSLLYDIQDVMAAKGNPRSEKADIDLDEALRAKIKTIGEKFEMRELHYKALLRSKDAEIQCLTAKYEEQRRTAENEAARCRALSSQVSTFSHTEAELRSQLNIYVEKFKQVEDTLNNSNELFLTFRKEMEEMSKKTKRLEKENHTLTRKHDQTNRNILEMAEERTRNHEELEKWRKKSHHLEALCRRMQAQGRGQGLAADLDGDDEGTESEYDEDYEDEEDDEGISDDDYELDSPDGDMNGDRNIPQQTEKPVFGPPPPPNLLEARANGNKAMINGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYZ7</accession>
    <name>A0A370PYZ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_287906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYZ7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
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    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="486"/>
            <end position="590"/>
        </location>
    </feature>
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            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="590" mass="66282" checksum="6E3C47BABDD05FC7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZP0</accession>
    <name>A0A370PZP0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_322673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZP0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="18042" checksum="A8B25B5E330943F7" modified="2018-11-07" version="1">MPLFHSSSHSSSDRSSIDDPNTTSSHSHRRSHRSSGSGSYHSSSSTSPSSSRHHSHSLFGHNRKNEDPSILAAKEQVSRAEAAEREADRALMASKRAVREAREHVRRLDEEAKMEARAAKMKQDQVKSITKRAKPLGIGNPLAYYDETQCICYIVVDWILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q072</accession>
    <name>A0A370Q072_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_260925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q072"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="36724" checksum="E721E4E77108C199" modified="2018-11-07" version="1">MSSASEVSWEVSFLQVQTSTADAATDTLFANGHMQVPVIVTIKAIDPESASTYELKDSDLKNIKLIDYDDENPATEISGSWSYSATENEFEHALPTSRKEPQPDLSLADGDPQRKRYWVTTTKIENKRIGASIQQPDGTVVHTASAAFDSKATLRGINPETYTKDDLNLERNDTANGDFYSPNYHWYWDQDNYFLTSTKYEFRKVELYSYDGGSSDPYLKYSTGFFSVHAPCNIFYYWPMGSQETRTVGKGLMTTEITMNQRLNAMCCTRMMFTGANPWEESHYWEGKFTIYDKFGNFGTFFMGYDEDRNQMQILTKKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0D8</accession>
    <name>A0A370Q0D8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Developmental and secondary metabolism regulator veA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Velvet complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_7605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0D8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="11">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="234"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="555" mass="61288" checksum="EE1CFA9369B94102" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0F4</accession>
    <name>A0A370Q0F4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_7835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0F4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="479" mass="51653" checksum="0D292BAD33BD8142" modified="2018-11-07" version="1">MSLFGQPAAPSTGGGLFGQANNTANKPSPFGGGGGLFGNTSTTNTTQQNTTGGLFGGATQTQQPSGGGLFGGATNTQTQQPSGGLFGQTATQQKPAGGGLFGGLGQTQQPQQQQQQTTGGSLFGQKPLGGGGGGGGGGLFGQQQQSQTPQQQGGGLFGGLGQTQQPQQQQQQPSLFGGSLLGGQQQQQQPAQQQQQPQLGQTQMGQSTAQLGSSLWEPGRAVTGVHRTVPMQIQIVKDKWDASSRASPFRAYLYNNVGEEMAPFYQPGPEDDDTKWEDALRKRPDSGYVPVLVKGFFELGKRAQRQKDFLTMMQTRLHEINNCLSDLLSRHDLKISVKIADCRRKHLVLSKRCLALAAKTQVLRNRGYAMDDAEEELKKKLSQLERSVFDPSLNGRAEEIWARMLAIREHSRRLQQEMERAGPGAAAQADDELDEQTMKTAKKILDDYHTQIQHLQKELEAVRKDFEEAQKLPGGAVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0U8</accession>
    <name>A0A370Q0U8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_322977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0U8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="39657" checksum="988DD863E3EDC552" modified="2018-11-07" version="1">MNRVLALPALFFCLFTYTPSYTTFNLIFFYMTWTTLILSHSPFKVELFGSIGVRLLFYILPSALLFLFDALVPSAAVLLKAHGEQGLPTGSKRRGVRVREIKVAGWSFLNIFISIAVQAAIETLRIGYFNTRSALKVSFTIPIIPWNIAFHLACVLLLREILAYTIHRFVLHNDKYRITRYISSLHQTWYHSLHAPYPSTAHYDHPIPYLLGNTVPTLLPAVFLRLHMITYAMYLSIVSLEETLAYSGYSAMPMDFFLLGGIARRVEKHLLNRAAGNFGPWGIADWFCQTTIGDEEGEVLIADTEDDEDEPTPVLRGKEIFEAKVQEALDSHAKKTQRKHKKKLKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1U5</accession>
    <name>A0A370Q1U5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_323012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1U5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000024">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="97"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="804" mass="88784" checksum="8AA5E1896584F83F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3H6</accession>
    <name>A0A370P3H6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable Xaa-Pro aminopeptidase PEPP</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Probable Xaa-Pro aminopeptidase pepP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_125661</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3H6"/>
    <dbReference type="SMR" id="A0A370P3H6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK36405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="466" mass="51472" checksum="162A26E9A5A823F8" modified="2018-11-07" version="1">MTTLDSILAGRYPAKAHARRVAERLQVGGSGRNGIIYLEAQKTRLIEDNDEAMHFRQRRPFFYLSGCPLPDSSLIYNIASDKLTLFIPPIDPEDVIWSGLPMSVAEALRLYDVDQVLHTTDVNATLASIASDGNGKSVAFAIEGQITEGIKFDGFLETNTSVLKGAIDSTRVVKDEYEIALLRKANDISAKAHIAAIEASKTATNEREIEAAFLATCIANGARDQAYHPIVACGQNGATLHYGRNDDDLVDPVTKAGKSSVLIDAGAEYRTYCADITRVFPLGGRFTSETQEIYKIVLQMQLEAIAMLKENVQWEDVHAHAHRIAIKGLLKLGILRGSEDELFEKRISVAFFPHGLGHYLGMDTHDTGGNPNYADKDTMFKYLRVRGRLPAGSVITVEPGIYFCRFIIEPYLTSPETSKYIDTNVLEKYWNVGGVRIEDNVHVTQQGYENLTTAPKAIEEVEVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3J8</accession>
    <name>A0A370P3J8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm to vacuole targeting Vps64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_299257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3J8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="747" mass="80975" checksum="5DA555CD28C7C1CA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3R1</accession>
    <name>A0A370P3R1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_226257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3R1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK36506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="234" mass="26131" checksum="0BCA581961AD6D37" modified="2018-11-07" version="1">MASSLSSRRTLSGFPLLTAEEFETACHAFLGRVHVVDDSKVGWSSIRLDQRATGPILSIARDIGHVGTRDRDEPLPDPEMNEELQWKASEEDPEALIRAPETSVHLQVIYNILLSPTYHVPVLYFQLRQDNHPGPLGIDAVYQYLVPEQYRKELQSIGIMGGISFGYRPDSGTPAFFVHPCQTTDAMRHIAGQLCLTPEIYLIIWLGLVGNRLGLQLPKELFTVEGMETFQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Y6</accession>
    <name>A0A370P3Y6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_340384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Y6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720100" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK36564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="272" mass="28396" checksum="EE29F7EE0CE9CA1B" modified="2018-11-07" version="1">MPSMNMFTSLLATASLMASGVYAAEASDMGAAAFLWPPDRAWGATWDTTAPCGSSAGVTNRTEFPLTNGAVSIVLQDESYSVNLAISFDNDPTKNADFTTVVAGSRFPDVEPGHECYSVPNPPSNITSGSNATLQLKYISDFDNDGNETYYACADITYVPYSSFTTDIPCFNVSEADTSSSSSSSSSSATTSTSSSSSSSSGGSNGLSGGDIAGIVVGTVAGAALIGAAAFFLGRYWQKRVQREHEVAMNMMNPVQKTWSASTAGRQQQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P420</accession>
    <name>A0A370P420_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_322305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P420"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753840" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="195"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="395" mass="44365" checksum="B2A14A2B5B94D89A" modified="2018-11-07" version="1">MHNGYIAALLLLSSSSNALAEQRTTDEFTFSCDPLTTQLSDPIVAPGKPSTHTHVVTGGTAFQRTMNESTAQNAKGTTCEVDIDRSNYWVPQLYHRLRNGSFELVEYQSSVGIALDFAGSPENLVEDRDELANGLDRVFITLIERVIIRLVLRIVMRSWFHWRRRKVCACLLGIRVFGSFACFIFRWVRVLISDGNRTYNDSNWSQRAVSHMCIGKDGSSNETKGLPQQPCEILRSQVFMSSCWDGENLDSSDHKSHMAYPDTGDYNKGVCPKSHPVAIYSIFLEFFFNTAPHPDYKNWIYATGDKTGYGLHGDFMYGWTDQVALQQAIDTCTGPQGLTDPDCSITRNQTRDLAPMPQPLDVPAPDDNIGQHGPVDRLPGHHNWVTEHDNSTWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4K1</accession>
    <name>A0A370P4K1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="10" type="ORF">M752DRAFT_280148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4K1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="196" mass="22564" checksum="53F34F96B39D4728" modified="2018-11-07" version="1">MLSLLWSVFLVHVAIYLVNTIGASTIDNLLWLLYLKVPTPTSKKYKEQNRLKREVVQLKRDMNNTSSQDEFAKWAKLRRKHDKTMEEYEAINKQLVSQKTSFDWGVKIVRWFGTSGLKFFLQFWYSKTPVFHLPEGWLPYYVAWLLSFPRAPMGSVSIQIWSNVCATAITTMAEVVTAVLLQRATATAAPAAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4V4</accession>
    <name>A0A370P4V4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">M752DRAFT_225374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4V4"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000143">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="366" mass="41184" checksum="0F2D3F4C1C3517F9" modified="2018-11-07" version="1">MPGKELPDRCMNCHEAEPAFLLRERHVCQECYIRFLNFKPFRRMERYRLRRNMPQTGPCKLLLPLSYGVSSTVLLHMLHRQLEALRSKKHGPAGFEILVLVVEPSTISPVPPHEEGFALAQQTFPLCSFTRLPFHSIFELDPDVHQIMSQYAGEHFTDDTSLSDEERLNRFRRSITTATSKSDVDQILLNKLVVAFAKKMECRGIVWGDSDSKLAAKTLANVAKGRGSAVTWQVCDGMSPFGLEFNFPLRDVFTAEIRTYATLFPELAGIIVHDEPPSENTLTKNLSIDELMIRYVSTQGEKYPGVMLNVTRTASKLQSSGTSIGGLQCNFCGAFMTTNENITGEQGNEQLQFCYACARSQPELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P501</accession>
    <name>A0A370P501_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_310682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P501"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="506" mass="56759" checksum="0C9A134BB815E7CC" modified="2018-11-07" version="1">MVKVTWQSPHGLRCSLKAPVSFSGRGLATTSQAPRKEGDISSVFVSLSGAKEKALPPRFADQKKRLIAGREEAVKKSWDRLLHRLREEVRTIERMGSDVVPTIDFKDIKTASKDFRRELRKRGVAVVRGVIPEAEARRYKEEIEEYVRANPQTRAFPPTDPQVFELYWSQSQMKARMHPNMLETQRFLMSFWHSKNSDALVSPSHPLTYADRLRIRQPGDAGFALGPHVDGGSVERWEDNGYGLGNVYKAIWEGRWEDYDPWEASCRIPAVSDLYNGAGACSMFRMFQGWLSMSHTGPKEGTLLVNPLLSMATSYFLLRPFFEPIYSPPAGSSRLALDTYLDPTNWRLETETSSKLEGATPGYSQELTDVLHPHLRLDQTMVHIPQIAPGDYVAWHSDGIHAVDKVHQGQGDSSVMYIPACPVTEENAAYVQRQREEFIAGTPPPDFPGGEGESNFVGRTTEDSLRHSQTVNALRSLGLAAFDTQEVGIKLGQKLVLERANQVLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P532</accession>
    <name>A0A370P532_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_259413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P532"/>
    <dbReference type="SMR" id="A0A370P532"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="246" mass="27917" checksum="E895E0EDAB68F38B" modified="2018-11-07" version="1">MPRSKRARVVHESKTTKKSHKEQTRRLYANIRECIEKYDHLFVFGVDNMRNTYLKDVRTEFADSRLFFGKTKVMAVALGHNPENEAAPNLHKLNPYLTGAVGLLFTSRDPQSVTDYFESFRPLDFARSGTVSTRAFSIPNGQVYSRAGEIPVSEDEPLSHTIEPELRKLGVPTRLVKGKVMLELTEGQEGFPVCREGEVLDSRQTTLLKMFGVVMAEFHVALKAHWTRESGEVEILEKDEAGMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5A7</accession>
    <name>A0A370P5A7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="4 9">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_310476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 9"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5A7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016828255" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="12">
        <location>
            <begin position="393"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112181" checksum="86D80B5BAA63A86F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5E8</accession>
    <name>A0A370P5E8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="4">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_279862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="4"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5E8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="517"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116147" checksum="491BD4DDDFDA9EA1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5F9</accession>
    <name>A0A370P5F9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_279859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5F9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="123" mass="13725" checksum="5415E26444F4ABCB" modified="2018-11-07" version="1">MTPILYDISLDLLADNEGVIDQQHSPEQHESDATPWLLITRSGGNMNLFKLCKRPSIRHLPLASSALRSIEQVVGVHDNLAPYHAFPTLYFCCQCGDGPKSWDNQPRCAICNHNICGYCMPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Z1</accession>
    <name>A0A370P5Z1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_105517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753843" evidence="5">
        <location>
            <begin position="22"/>
            <end position="5728"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="810"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1918"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3000"/>
            <end position="3076"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4088"/>
            <end position="4164"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5207"/>
            <end position="5283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="5728" mass="633507" checksum="48E3A3A99FA66E26" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6A1</accession>
    <name>A0A370P6A1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_298267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6A1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="68" mass="7389" checksum="236DF501835A1EEA" modified="2018-11-07" version="1">MAPGDKNAGRDEAAYRLNLGESQAEALRKQGVRSGEKRGKSYEPSSLRLPNEREEDQLAKAATADSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P864</accession>
    <name>A0A370P864_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_222349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P864"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="57541" checksum="C65EFEB3E8B552DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8I8</accession>
    <name>A0A370P8I8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_279051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1384"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK38461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1467" mass="157998" checksum="B532C7F7BEA082B1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Q8</accession>
    <name>A0A370P8Q8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Q8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041021105" description="Hydrophobin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="122" mass="12504" checksum="A089B76ED0C7BB15" modified="2018-11-07" version="1">MKFAVAAILGFAMTAVAIPAAKSSQQKLSIDDASGQCSIGDIYCCNPTNEEETDGALNNALREGLLIGSLVNGKGSACAPTSLIGSLNLLAFFEEGEDDDKSYCKNVIACCPGGNCAALDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8T0</accession>
    <name>A0A370P8T0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_76516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8T0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="351" mass="38824" checksum="7EC57F1765A0BACE" modified="2018-11-07" version="1">MPTARYFAQAPPFPANTPTINLPILTFSQLQSGNPIEAEKLFAACREWGFFLLDLHDSADGRTLLHDAESMFDLDTELFSLDQSTLDQYAYNAPKDLTGYKRMGALKTDDGKLDHMHLYSINQDDILGKRPPRTNAPPIEAHRPQIQAFIRHASSALDVILTTLDKQLGLERDTLSKLGPLDHESETSVRLLCSPPHTSGDAERDRISLGGHTDIGTLTLLFHVIGGLQILPAGLENNMENWRFVQPLPGCALVNIGDTLVEWTGQLLRSSLHRVLAAPGEQAFVPRRSVAYLVRPAKSASMRRIRGGKIPAVAEGEVEEKRSVDEWAAWRSKQIMLGLLKPQTRGGVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P909</accession>
    <name>A0A370P909_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_222013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P909"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="335" mass="38035" checksum="24B00CE919B1B581" modified="2018-11-07" version="1">MEPSQHHLPQISLAFLALLAVPITALVWDRILNPLPTTKRAWLVGKKQPSRITSLECPYSYIRQIYGKHHWAPFVDKLAPSLKLEDPPKYQLILEIMDGIHLCLILVDDISDGSNFRKGHPAAHKIYGPSETANRAYYRVTQLLNRTVHEFPRLAPFLMQCLEEILEGQDMSLVWRRDGLASFPVAPKERDAEYRRMASLKTGALFRLLGQLVLENKSMDATMTTVAWCSQLQNDCKNVYSTDYAKAKGALAEDLRNGELSFPIVVALDAPEGHLVARALEYGSPYNIRNALRVIQREDVRSACLWDLKKSSASVQDWLEVWGRKEKMDVKSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA95</accession>
    <name>A0A370PA95_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_239053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA95"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="399" mass="45104" checksum="1B34F4E6B26DA0B6" modified="2018-11-07" version="1">MNGFASHGLDEDAFGEKSGLQGGLKTFDAFPKTKPSYTAPSRRGGQWTVLILVICTVFTFSEFRTWLHGSENHHFSVEKGVGHDLQLNLDLVVRMPCDTLDVNIQDASGDRILAGDLLQRERTSWKLWMDKRNRETSGGVHEYQTLSQEDTDRISAREADAHVHHVLGEVRKNPRRKFAKGPRLRRGDTVDSCRIYGSLEGNKVQGDFHITARGHGYRNFGEHLDHGVFNFSHMVTELSFGPHYPTLLNPLDKTIATTETHYYKYQYFLSVVPTLYSKGASALDTYTNHPDLIATNRNRNLVFTNQYAATTQATELPENPYFIPGIFFKYNIEPILLMISEERTSFLSLLIRLVNTVSGVMVTGGWVYQISGWVGELVNRKRGRGKSEGVLTGKHYAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAB1</accession>
    <name>A0A370PAB1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAB1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="340" mass="37158" checksum="EA950F75B9CB481E" modified="2018-11-07" version="1">MASDIPKVVPLTCHGHSRPVPHINFSSTVEDDQYYLISACKDNNPMLRDGITGDWIGTFLGHKGAVWQARLSTDANLAATAAADFSAKIWDTHTGECKHTLQHSHICRAVAFPIQPSPQVVATGGFEKKLRIFDLTRSGGSNSSSPTSATPNNDASPSAVTSYEIGPGVHGGTIKSIVWNQDYNILTTAAEDRKIRWWDLRSRHPVVEYAVEGTIGSCELNSLAVRPNDAGILTVAAGRSVYLFDGLSPGRLLKKIDFRYEVASAAVNNETSRLVTGSAEDTWARVYDVRTEEELEVQKGHHGPIWSVSFSPDGKMYGTGSEDGTIKLWKACREPYGLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAC8</accession>
    <name>A0A370PAC8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_278592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAC8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="207" mass="23208" checksum="776C61DF408ECBC6" modified="2018-11-07" version="1">MSDPKYAGSKLLSRGPLDPKEAKWTRLVMSSYTDPNGVERTWESAERQTRPANCEIDGVGIVTILNKETGPELLLQKQYRPPIDKVVIEVPAGLIDPNETVEECAVRELKEETGYVGVAEQTSSVMYNDPGFCNTNLNMVHVRVDMSLPENQNPKAQLEDNEFIECFTVPLSSLFEEMKKLEREGYAIDARVGTIAEGIELAKRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAS0</accession>
    <name>A0A370PAS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_305131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="678" mass="75490" checksum="34AEAEF721BE7674" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAZ5</accession>
    <name>A0A370PAZ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_285726</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK39363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="683" mass="73175" checksum="1D07FFB313C4AE16" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB23</accession>
    <name>A0A370PB23_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_296419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK39379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PB23"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="506" mass="55798" checksum="C530756C15705D35" modified="2018-11-07" version="1">MQGQALRYAQIFLVACPSFILFGYNQSGVGGLDDFPSWVRVFPEIDTVNTTGAQESHNATVQGAVVASYTIGALFGSLICTMIGDMLGRRRSIFSGALIALIGQILECTAYSLAQFVVGRVILGFGVGMLSATVPVWQSECAPAAQRGRNVVLTGMFIAFGFALTQWVNFGFYHMENSPASWRASLAIPALFSFIIMGSIFFLPESPRWLVMKNKSDVAQFTLASLRGKEVDSLEVVAELRAYELSLEESSNNSLRLRDIFSMGEEKLLYRFILCVTLQFFQQMTGGTLISVYIPLIFQTDLGLGASLSKILAACALTWKFLCCFVGFAIIDRMGRRTAFMVSGGGMGMCMLALAVSNSFSNNHTASIISALFIFIYNFFLPIGFLGANFLYPAEVAPARLRVAMQAISIANQWLWMFVVAMITPVAIDNIGYRYYIVYAIIGGIIPPIIYLFYPETKGRSLEEVDEIFRDAPTIFAAVSMSKHKPMGDRAMERVMEEKATVEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB66</accession>
    <name>A0A370PB66_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_238759</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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            <end position="46"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="1279"/>
            <end position="1302"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="646"/>
        </location>
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        <location>
            <begin position="681"/>
            <end position="936"/>
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    </feature>
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        <location>
            <begin position="1011"/>
            <end position="1336"/>
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    </feature>
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            <begin position="1373"/>
            <end position="1638"/>
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            <begin position="401"/>
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        <location>
            <begin position="930"/>
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            <begin position="404"/>
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            <begin position="962"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1663" mass="183550" checksum="12021507C0F99EBE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC06</accession>
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        <name evidence="9" type="ORF">M752DRAFT_304950</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">ATCC 13157</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="545" mass="60859" checksum="349BE39F0A9A3717" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
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                <person name="Hainaut M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
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    </reference>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="PANTHER" id="PTHR24320:SF252">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="330" mass="36288" checksum="BEA6C92FC12E2F1A" modified="2018-11-07" version="1">MVKFFQPKVDPLPTGIDLTGKTAVITGASAGMGLEVTKQLLRLRLSTAILAVRNVTKGEACIKSLLQDRGIQTHNPKPTIKVMELDMDRYDSVQQFAKTLREEVPVVDLLILNAGVASLNFERSPSGHERVTQVNYCSNVLLVAELLPHLEAGAEQTGSPARISWVGSRSHETPSFEKKSPIGADEGVLEHMDKEGAFVPFQRYNDTKLLCVLFLYSLAPRLDPKKVVINTMCPGMVNTGMSDMLPLHLRLIFNVIKAIRARPVEVGGWIILNAAIVAGPESHGKFLADKTITDKSAIVTSPMGQDIQKKLWEETITELSKLTTLPPQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCF1</accession>
    <name>A0A370PCF1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_45401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCF1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="90" mass="9771" checksum="C98807F68E1E2FA7" modified="2018-11-07" version="1">MWMVDVTGECAHVIFSSLGIPFIACLNRLLQFYPLRLCLVESVCFLLAVCCSAARDRLVQTLHNAALHLIAGPPIGDTHGPSNVPKIHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCR4</accession>
    <name>A0A370PCR4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_268425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="178" mass="20267" checksum="3AEFF9EB5AB8345A" modified="2018-11-07" version="1">MSLWVTVGTCTATRTFRQILAPTHVRADWRTRMANDFWDAKPVPPKMPKEAEMRDESTQVGWTTDLCPKVSTTTGTIVIQAFEPVYLKPEMGNSFWKFATADGQTIAESTIQLLSEHTFQKDHDDHLARRDPSWTAIRLLVEDRSARTKAYMRIYKQLMHGGTEAEPTRAKAFAHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD04</accession>
    <name>A0A370PD04_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_48132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD04"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="178" mass="20292" checksum="D3EB5E6DE90B395A" modified="2018-11-07" version="1">MTASIRDTLTCSNAVCAGWRSYKSNSGLILLIFHILFHFTLWLQMTEARLCTYVSVCRRFSGYCRRDAILPGASFSYAHFNTFPSFTKLWPGSFQEQLITTNHVYGSPQLADYLPAFGWPTRSSLRYGTQHPATIRACPFHGFIAFWAWSLSTHVTLIYLRQGFSCLITIPTLVTHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDE0</accession>
    <name>A0A370PDE0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_337411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDE0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="364" mass="40810" checksum="210EB91BC62B4642" modified="2018-11-07" version="1">MIHIEPGCSTKESRLPFEIEEWVEMAIGMFVILLRLYARTRAVGFRKWQGDDYLGIVALVLWVTEVFMFKFVFRFGANARLSDEQRASMEEWEIREREFGAKCLLVSWVVYVTLIWVLKACMLFFYNRLTIGLVQQRFVKVAAGLCLCTYVATILTILLHCNPVSKLWQIYPNPGKACTQGSANYIAILVTNILTDVVVLSIPLPLLIQVQLPWRRKLVIALLLFGGVFVMVAAVFRCVLSLWHIESVNTSNLWATRETVIAIITVNIPCIWPLLRRSSSSREVSTGASGTGRYKLGPLAGTGTANRRPAGPESILEDSQSQFVSDVRGGTDRVGDETGRGIDGIQVTTVYEVKHDPYGVKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDK0</accession>
    <name>A0A370PDK0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDK0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="294" mass="31739" checksum="B2AAF7B00D84F60D" modified="2018-11-07" version="1">MAPPTATETTIFSPVPVQAHSTQEAAAEAAKVKNTPQKFPQPPVFEDKYKEREYLKGRLAAAFRIFGKNGYDEGVAGHITLRDPVDPTTFWVNPFGVAFSQIKSSDLIHVSHAGEIIGGGPVRLLNAAAFMIHSAIHAARPDVLCAAHSHSIHGRAFCTLGRPLDIITQDACAFYNDIVLYNQFNGIVLAEEEGKSIAQALGNKKAALLQNHGLLTVGQTIEETVFWFVSLEKCCYVQLMADAAAAGRGGQTVKVDEADAAFTYKSVGTPRAGYFSAKPMFDLIHEETGGSYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDN7</accession>
    <name>A0A370PDN7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_254923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDN7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63693" checksum="6B5C5BD8E4D66DFA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDR4</accession>
    <name>A0A370PDR4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_328380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK40332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="523" mass="59926" checksum="CDAAE4618D2BCF25" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE01</accession>
    <name>A0A370PE01_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_295601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="377" mass="39148" checksum="54F5284A22758DE6" modified="2018-11-07" version="1">MTVPIDNANGSTAVPEIPAKQKAAIYDQPGTVSTKVVEIDVPEPGTGEVLINLTHSGVCHSDLGVMTNTWRSLPYPTQPGQIGGHEGVGKIVKLGPGAESSGLKIGDRVGIKWVSSVCKTCEPCQAGADGICFKQKVSGYYTPGTFQQYALGPANYVTPIPDGLASDEAAPMLCAGVTVYAALKRSNARPGQWVVISGAGGGLGHIAVQLASKGMGFRVIGVDHGSKEELVKASGAEHFVDITKFPSDDKGQAIATHVKSLAGGLGAHAVIVCTAANAAYAQAVPFLRFNGTLVCVGIPENAPQPIATAFPGKMIAQHYTITGSAVGTQRDAIETLDFAARGIIKAHFRTEKMDALTGVFEEMSQGKLQGRVVLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE12</accession>
    <name>A0A370PE12_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_43216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE12"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="453"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="820" mass="94292" checksum="03A81C3FBFAF7E47" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEC3</accession>
    <name>A0A370PEC3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_294971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEC3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="131" mass="14530" checksum="90783367DC2728AA" modified="2018-11-07" version="1">MTRAQQTLSVLLLVSSLYLVLYLGLVPLNETVQTEVIPVVRSSSLTSATNNPPPPIYNISDSQFHTYSLLIIAPCHSQLPFYALICFGCYLLGRLGLAILTFNDVPEAHDELQKEIEQAKAELRRANVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PES2</accession>
    <name>A0A370PES2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_35765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PES2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="171"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="46154" checksum="5A87E07885F13D0A" modified="2018-11-07" version="1">MRLSPIYALSWALQASATILQNGQVREDPYPGQAKAISLDNGSWRTYQPDASEIAYKGRWDSKHVSWWSLPGIKLGFTGEQLAVSFGPQTSEGVLLAYRIDGLDWQFSNVTANSTYQFAGSWTPGLDLSKNNTFEMRVTNWGYGVQLAGVSVASDSQLVTVPQYNKTVEIIGDSFASGQYGTYEGLSSWAYNYAAGLGDVEYSITAYPGICLTDEQCYADKARGMTHQWFYASDAGVRANATYGNQPEKWDFSAHRAADLVIIDLGTNDHRAVNDIPGSTFYDSYVELVTSVHETWPDAQIVIMSLWGNFTRSGDTYVQSPFYVSEIQRVAEHFQDDGFVYYFDTKGVLQHNDIDPQEHPTDVGHIKVASHLMQWTKLKLGWEFGATGPEVQHDTLYWNNEDSYRRSFTGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PET3</accession>
    <name>A0A370PET3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_303419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PET3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016478404" description="Cutinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="26690" checksum="3A178BD7633E5C88" modified="2018-11-07" version="1">MAPLKSLLLGASLATLALSTPLATDADNLYARQFGTGSTANELEQGSCKDVTLIFARGSTELGNMGTVIGPPLCDNLKSKLGSDKVACQGVGGQYSAGLVQNALPQNTDPGSISAAKQMFEEANSKCPNTKIVAGGYSQGSAVIDNAVQELSTTVKDQVKGVVLFGFTRNVQDHGQIPNYPKDDVKVYCAVGDLVCDDTLVVTAMHLTYGMDAGDAASFLAEKVQSSSSSTTSSSSDSASSSSAAGTSSSGLSGLSSFFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF77</accession>
    <name>A0A370PF77_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_254066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="440" mass="48838" checksum="0729EA0B969A59BF" modified="2018-11-07" version="1">MPIPIITTAITEGTNSIPHLWTVLKILPWAVLLAALKYYFGGARNTSERLMHSKVVMITGGTSGIGAQVTSALASRGAQIILLTQHPPTDIFLAEYIEDLRRSTNNQLIYAEQVDLSSLHSIRTFATKWIDNVAPRRLDMVILCGNAAPPVSQKRKLTVDGIDEEWMVNYLANFHLLSILSPALRAQPAHRDVRVVFTTCSSYIGAKWDLRQVEASAAITAAAAANAEGDNGEGRRVVMKNGKLQREKPKSKKKKTKGVSLYGLSKLSLMVFAQSFQKHLNSFKRPDGQPCSARVIMVDPGFSRTPGMRRWMTGGSLWGLLVYLVTWPVWWLVLKSPQQGAQSVLYAAMEAEYGRGEGGWMIKECKEVDLARKEVKDEEAGKMLWEFSEKLIEAKERESAVRRALANKEKEVAEENEKNKASGSGAKEQTPGSRRSRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGA1</accession>
    <name>A0A370PGA1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_267249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK40924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGA1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="322"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK40924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="667" mass="73951" checksum="DBA63162E88036E0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGJ0</accession>
    <name>A0A370PGJ0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_336517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGJ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="540" mass="59069" checksum="C21BCEC8DF0EF1B6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH00</accession>
    <name>A0A370PH00_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_235732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH00"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="769" mass="86162" checksum="EAA16A7BAB7DE190" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHB6</accession>
    <name>A0A370PHB6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="42479" checksum="8BF18C07C2192934" modified="2018-11-07" version="1">MATEDDNFDIDIYGDGGGYNANEQGDFKPEDEMKHDDTELILDAPEPTQNGNPNQGDGSSDGTVKPDSEGGAPHSDPVTQAANPQSAAKDTPAPQQGVKRKEHDDRPTDPDATPALLISDLYWWTTDDDIRGWVCQADCEDELKDVTFSEHKVNGKSKGQAFLEFTTLQAATATKHKIESFSAGGQTRKHMVTYTSPQPNPFRTLPKDAPMRKDNQARSMSGGFNSPNPNMNFSGGMNNMGGGYRGGRGGYNNRGGMSGGMGGNFGNNRNFQNPMGGFQGPMVGGGFQGNPMGMQNYGFNNRGGMMGGMRGGPGGMRGRGGGMAGPNMMGMPGMNPMGGMGMNAMPGAMNPMMGGMTGNMGMQGQGGFQGPNPAFNQGFFPPNQGVGDGSWNPHGAKRSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHS7</accession>
    <name>A0A370PHS7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_294570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHS7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="144" mass="17228" checksum="48A466556FCFB9BC" modified="2018-11-07" version="1">MDDRWSDAEIIILIYFTSRGFTDLAVSHVLHVRGYWRPPSAVWQMLQVILEQYPYLQTKTGHWDIDQVDEWIDSLSMEHEAVNWLISCTNIDAAIAEENYWKRFWETLPISVQGAHQLLRRPIKIQYNNCCLHLRFQEKDHNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHV6</accession>
    <name>A0A370PHV6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_276473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
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        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CENP-T/H4_C"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="36"/>
            <end position="96"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK41742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="11386" checksum="2696CB0E75674EFF" modified="2018-11-07" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
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    <name>A0A370PIB2_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_21946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
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                <person name="De vries R.P."/>
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                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="57" mass="6544" checksum="791DBC4008E55C60" modified="2018-11-07" version="1">MSFSIIFPLLSLSFQAERRMHLVFLIVGMIGTTYYLSTTCLLARHLAHQPSNFQPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PID4</accession>
    <name>A0A370PID4_ASPPH</name>
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            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
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        <name evidence="4" type="ORF">M752DRAFT_252311</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Vesth T.C."/>
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="113"/>
        </location>
    </feature>
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        <location>
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            <end position="104"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="780" mass="88025" checksum="5EF5F7C9E8C29378" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="73"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="363"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="671"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1444" mass="159646" checksum="1A0F38B40F91F856" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJZ7</accession>
    <name>A0A370PJZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_251629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1503"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1535"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1605" mass="177950" checksum="21B30D815707C467" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKF3</accession>
    <name>A0A370PKF3_ASPPH</name>
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        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_314937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="protein sequence ID" value="RDK42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKF3"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016761522" evidence="9">
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            <begin position="25"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="12"/>
            <end position="461"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="56895" checksum="72533940822C466A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG1</accession>
    <name>A0A370PKG1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30kD heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKG1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="186" mass="20598" checksum="1AF9FF0FAE63E8B8" modified="2018-11-07" version="1">MSLFRTIPTAGDFAPLFRLLDDYDLHRSSQGSSVTSARTFAPRFDVRETSDGYHLDGELPGIAQKDVDIEFSDPQTLVIKGRTEREYHSSDNDEAQNTPTPENTNNNNQGEGSAVVPSGDKQVSKNKSKAKHHYWVSERSVGEFHRTFSFPTRVNQDAVKASLKNGILSIFVPKAAAPSSKKITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKP0</accession>
    <name>A0A370PKP0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_318926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKP0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="484" mass="53740" checksum="2C22004F84D9A8B3" modified="2018-11-07" version="1">MAIDNATSRPRKQLILNAFVEMCSGHQSPGLWRHPEDESHRFNDIDHWIELAKLLESAKFHGIFIADVLGGYDVYKGPRNLEPAIISGAQWPVNEPLAVVPAMAAATQNIGFGVTVTTTYEQPYHLARRLSTIDHLTKGRIGWNIVTGYLDSAARNLGHTQQPQHDDRYAQAEEYIKVTYKLWESSWRSDAVVLDRTRGIYTDPTRVREINHSGKYFTVPGPHICQPSPQRTPVILQAGTSKAGKAFAAQHAEAIFVAGHSPSVVAKNIAEIRETAKTQFGRDPAGIKFLALLCPVLGRTEEEAQEKFRYFRSLGSIDGALALFGGWTGIDLDRYGEDEELRHVESNAIRSAVEGWSKATPEVEKWTKATVGQHITVGGLGATPVGTPEQVADEMERWVNEADVDGFNLAYAIKPGSFKDIIDLLIPELRKRGLFWDDYTVKKGTYRENLYSKEGQSGPPADHPAAKYRWHAGVEAADHPVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL07</accession>
    <name>A0A370PL07_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_214272</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL07"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000133">
        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000383">
        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="847"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115228" checksum="3A4EE4AAD02D5C3B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY6</accession>
    <name>A0A370PLY6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="75109" checksum="410361BA33494B69" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PME0</accession>
    <name>A0A370PME0_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_314515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="TesA-like"/>
    </dbReference>
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        <property type="entry name" value="Thioesterase"/>
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        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="596"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="966" mass="105646" checksum="4F5DDD1CC0BF0541" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMR6</accession>
    <name>A0A370PMR6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_335274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="174"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="277" mass="31195" checksum="DE31D0CB9AFEC978" modified="2018-11-07" version="1">MSPRTPGKASRPGAARRRRGRRKLTPRSPLSLLAQTRKNSVVKKRDRGDVVSSTKTKLTERRSKPGRSSRLNLLPLSTEPREKNCFRRDVSPANYRFVPKGNIYITRNCRKLTKESGRVVYVVYDDRGKNTLGLRVPVDIHEAVLRLADETAHSRAQAIQVRDEKDSAQARQLLRAQFPLMPDESLDTILEHAFLKGSGRVGRTSRLSDEDKAKLAVEAHIRHTHTSYEALLKAGKTRGEARQASKEMVQAIRTAWAGGNVEPTDCLTMRDRVIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNG0</accession>
    <name>A0A370PNG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_275026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="626"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="682" mass="76484" checksum="2C1EF07CC4EFA23C" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNG5</accession>
    <name>A0A370PNG5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_326282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNG5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF79">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016985617" description="ribonuclease T2" evidence="11">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK43454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="29210" checksum="1A6E35B5E96E0BEA" modified="2018-11-07" version="1">MSFLPSVGMLALGAMQLSSGVLATIDTCSSDSPLSCQTDNEASCCFNSPGGSLLQTQFWDYDPSDGPTDSWTIHGLWPDNCDGTYQEYCDDSREYSNITSILEAQNRTELLSYMKEYWPDYEGADEDESFWEHEWNKHGTCINTIEPSCYTDYYPQEEVGDFFQQVVDLFKTLDSYTALSDAGITPSEDATYKLSDIEDALAAIHDGYPPYVGCEDGALSQLYYYFNVKGSAIGGTYVASERLEDSNCKDSGIKYPPKSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNH7</accession>
    <name>A0A370PNH7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_144335</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNH7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="11">
        <location>
            <begin position="136"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="369"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="516" mass="57258" checksum="EB56B10DC46F7C28" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNQ0</accession>
    <name>A0A370PNQ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyl pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_145794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNQ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="432" mass="46847" checksum="6884E728785D4E0F" modified="2018-11-07" version="1">MVRNIVVIGGTSHPQLTQTICNVLGIPPADVLLSKFSVGETRVEIKESVRGKDVYIIQSGGGKVNDLLMELLITISACKTASAKRVTAVLPLFPYSRQSDIPYNKTGAPLVKSSLAGRQGNNYTFESTPPTPHPGKPDGGSLLNGLNGVDNLQKSLAKAQLDDISNGSPVKKQRPVNGLPRSDTMESLQSEGNRFALNGADEKINNFQPRPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGRPLLKSYIQRNIPNYKQAVIVSPDAGGAKRATAIADSMGVEFALIHKERRPTRITDRQNATMMLVGDVKDRTAILIDDLADTSNTITRAAKLLKKEGAAQVYALVTHGILSGDAIDRINASALDKVVVTNSVDQADHLRRCPKLEVLEVGHVFAEAIRRVHHGESISTLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNS9</accession>
    <name>A0A370PNS9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_232094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNS9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="796"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117427" checksum="36DF7C971F4C510F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPN6</accession>
    <name>A0A370PPN6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_334973</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPN6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="376"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="917"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK44148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130274" checksum="9699917DE70A7B7D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPN8</accession>
    <name>A0A370PPN8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="71" mass="7972" checksum="B7F018BD80B81361" modified="2018-11-07" version="1">MPHQYIVSLNKESPPEELEKAKKTATDNGGKIVKEFALVKGFVVQYDDEQVSTLESSDHIHVEKDSEVSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPQ5</accession>
    <name>A0A370PPQ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_312966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPQ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="442" mass="48664" checksum="40D029D11B2BA7BD" modified="2018-11-07" version="1">MSSTTTGSSSSATSTDRNGNNNSSSPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQLRSEVTGEPIDLVAMPRTHRRRREKKLMTMDDVNERFPLTKYKAWRSSRENEGLSGAGGISAPNSRSQSPKDENYMLSASLGAPSSMVASPLKSHQRVDSNTSQASAPLENLETTLPQSEEKSQRYSEPSPTNIGVNDNANISAPEQPRNHALNHVIVEDVGDLEDHIRTAVPADFLANPGDTCAICLDTIEDEDDIRGLTCGHAFHASCVDPWLTSRRACCPLCKADYYIPKPRAETSELAPSSERQGRRGMARVTPINPPQAVFIGGRVNFLRPTSGSPEQHVQRRPLTHRAGFSRLRLWRASQSNHQPTSPVPDTSSGQPDRRAQRLALFTASYFPLNFSLRGNRASRGLANRNADVRHSENNRSLGELEAGPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ77</accession>
    <name>A0A370PQ77_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_231240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="36984" checksum="28A2669F97C5AE07" modified="2018-11-07" version="1">MATTSDSVPASCKVMLSKHVANGLLAEVQQGVHTLEKPPHLVGFLANNDPAALMYAQMTEKTCQENGFRYSLREVARDDLEQAILAANADSDVNGIIVYYPIFNNRQDQYLQQIVDINKDVEGLSHRYIFNMYQNIRFLDPETKRQKCILPCTPLAVIKILEYLNIYNTILPYGNRLFGHTICVVNRSEVVGRPLAALLANDGACVYSVDITGVQKFTRGEGLKKGRHEVVDLEGKTLKDVAPLCDVVISGVPGEKYKFDTSLLREGAVCVNFSSEKNFGPEVKEKASIFVPSIGKVTIVVLLRNLLRLIQNSRVDDVKPAEATERPGTLEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQF5</accession>
    <name>A0A370PQF5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_313235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQF5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="29961" checksum="2FB77B0D674DAB5D" modified="2018-11-07" version="1">MISRETLSPAYADYSVHTDQFSRFRATQSYYAKLVQAGLLKVTIPKSAAGACEEWVNHGLIVEELHNVDTSLSIHLIGTVLGLLPHIIGGTAEQKKFLAPFLSCDRDHLASLMRSGSGDTASHLKEGGKGLEITARKEEDIYIVNGEKLWTTSSATLDGKGVTLSCLVACCLEDGGTENRESPGDNIMVLLMTRDIIAQNSPGAYAMLSEPDFKGQVRRAADCTAVMILISDSRCIRALASSANASPAVCGLSGFDRTALRSKKRAATENIEKKGRGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQM6</accession>
    <name>A0A370PQM6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_325427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQM6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="860" mass="94096" checksum="5EA6E2832BBA5EB1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQR4</accession>
    <name>A0A370PQR4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_274812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQR4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="153" mass="17737" checksum="BDB374427B85E76C" modified="2018-11-07" version="1">MADEHYNAEEAAEIKKRRQFRKFTYRGIDLDQLLDLSSEQLRDVVHARARRRFNRGLKRKPMGLIKKLRKAKQEARPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQIEVKPEMVGHYLGEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQS9</accession>
    <name>A0A370PQS9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQS9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60532" checksum="0A8865141100AD02" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQT9</accession>
    <name>A0A370PQT9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_325497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQT9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF5">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="327" mass="35245" checksum="C753698096DC68A6" modified="2018-11-07" version="1">MSHPGILHHYTPRLVAFEFTPPNSTPTTNALLFIGGLTDGLLTVPYVPILASALSSTPNNTWSVFNVLLTTSYQGWGVNSLDRDIEDLAQCINYIRKLKGPESKIVIMGHSTGSQDVLHYLSAPNPIPQNPSVNGLQYLTRPPVDGAIMQAPVSDREGMHITITTAEARGAYEQLVGLAKAAVAEDPRAILPLNLTSLVGLDAETPVNAWRFLSLASPDSPGSPSQDDLFSADLGDEKLRETFGVVGKRGLLRGKLMALYSGADEYRMPGLDVEGLMKRWQRATDEGAGEVKWDAEGSAVVEGASHNVQDVGQEELVERVRGYLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR22</accession>
    <name>A0A370PR22_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_274947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="58764" checksum="089443050A8588AD" modified="2018-11-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRV6</accession>
    <name>A0A370PRV6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_333819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRV6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113881" checksum="F690277CDD934118" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSG9</accession>
    <name>A0A370PSG9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_312882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016836378" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="38291" checksum="64455911C8C8BE62" modified="2018-11-07" version="1">MVPINQPRSSALRFFLLVLLFSTANAHSWIEQLLAIAANGTFVGSPGYARGNVHRTTPGFSDPTMTYLIPPNDRANQSLILPTDKMCKSTQRTRNQTEGSPRLQAAAGSPIALRYQENGHVTLPWNQPGKPKNRGTIYVYGTTEPKEEENFLDVFNSWNRDGTGGDRRGVLLSKQNFDDGRCYQINNGNISEHRQAVYPHVANQLMGADLWCQQDIALPSNAPSGKPYTLYWVWNWPTAPGVDPSLPKGKQEIYTTCIDVDVVDSPTTHTHVQEGYVEGQSLDSAAIPSEFAEVMGSSTDSKEAGSSSVPYSSTPAPTPAPTSVAPFRVLTLTTVITTHIPVPSSDTLAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSH5</accession>
    <name>A0A370PSH5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_247856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSH5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="183"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="589" mass="67541" checksum="E5324E7B93381B78" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSI4</accession>
    <name>A0A370PSI4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_132642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSI4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="312"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK45121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="719" mass="76371" checksum="3A0A2603AAE0C30C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSK1</accession>
    <name>A0A370PSK1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial import receptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_291205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSK1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="8">
        <location>
            <begin position="217"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="444" mass="49194" checksum="8A0BED064B8B3C08" modified="2018-11-07" version="1">MVLELHIWGPAFSLPSIDAQCLAAITYLSLTVPKDAWVLVASSDPSVSPTCELPALRNGSTWVSRFRNIVDYLRQYSNGDWDLDQGLSGIEKADNTAFSAFLESRAQSLLDLSLYVTSQNYYNCTSPSYGAILQWPNQWILPPKLHSAAKTRTEHLGLSSLDIQAIEDQRKRDHSAAVAAGQIPKNLIPQPRDTVSSLLGKTAQQNQFKLEALTAELFEPLEEILNGKGYFLHTREDGPTSLDCLALGYLSLALVPELPNSWLRDAMRSKAPQLTAYTERMGKEIFGMVELEHALPTDDTQRSRSSILPWQAPQRARLATIGSTLYNTLADATPIWKDIRLNNRMKEAIDDNGELSGIERRTMSAFAAAQSKDVWLSVGYAVVSVVAFVGYLTLQPSIRKGWTQTIQAVKEEGEGEGEDEFEVATEGEGEIDLETDAMNILREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSQ7</accession>
    <name>A0A370PSQ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_291290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSQ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="27660" checksum="6F6C3231695852F7" modified="2018-11-07" version="1">MPTVTVNNHQVYYADTHPDGAPANGQTIIFIHGLGSSQNYYFPILPYLSNHRCITLDTYGSARSTYTGDAISIASIASDVVGVLDALQVPKAVAVGHSMGGLVVTLLGAQYGDRISGVVAIGPTHPSEKLTEVMTQRSETVSKAGMEPMANTIPNGATGSRSSALVKSFIRELIIGQNPKGYAALCLAIANAPVIDYSKVTAPYLLIAGEEDKSASMEGCEHIHANVSSAQKKLEVLRGVGHWHCVEAPEEVGGLIGGFVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTE9</accession>
    <name>A0A370PTE9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_290273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTE9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017027562" evidence="7">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="26313" checksum="5F31A195310CAC60" modified="2018-11-07" version="1">MFKSLALVALATISPSALCAPNTSRDIPFGQVITTCTTPNTIALTFDDGPSSYTPQLLDLLSEYKVRATFFVLGEASQSNPQIIQRIRQEGHQVGSHTFDHTSLPTLSYDQIVQEMTSLESVLQSTMGDIPTYMRPPYFDVNALTLQVMSDLGYHVITASIDTKDYNHNSPDLISQSYDKFVTELNNGGNLCLAHDTKEQTVVSLAKMMLDETKSRGLTVTTVGDCLGDPEASWYRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTH4</accession>
    <name>A0A370PTH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxaloacetate hydrolase class protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_290336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="335" mass="36730" checksum="F0D6740E385BABA5" modified="2018-11-07" version="1">MSASEVPYPFQFDSLRTHEPGVGPQDGTTQDVTVKLPNVRGRIPSLQASRLRTMMLEAHGDPNKILAHACSYDGLSSRLVEEAGFPMVFLAGYAVASSYGLPDTGYIAMAEMCDKIRDAVRQVFVPVMADGDTGYGSPLNVKRTVESFAAAGAAGVMIEDQQWPKRCGHTKGKSVVSREEAFARIKAACDARNQGLDIFILARTDALIHGWNEAMSRAHEFRRLGVDAVFVEALPDREAMKRCVQEVGIPTFANIIEGGKTENLSAKDLAELGFCAVAYPWTLVAAHVRGLREALDGLKRSMTVGAPPMILTYDQVCEGVGFNKYWDLEERYKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU61</accession>
    <name>A0A370PU61_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-ketoacyl-acyl carrier protein reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_317542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU61"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="251" mass="26615" checksum="9B60FFB992C952BF" modified="2018-11-07" version="1">MSTNDIRGRLALITGASGGIGSACAHKLAENGAHLALTYSTNLAAIQSLHADLQSRHPDLRISTHQVDLRSATDITLLFDQIIAQHDGHSPDILISNAGTGKRITNIWDIDLLDFDDMITTNLRASFILVKGVVEHMKAQRWGRIVFMSSIAAYGGGINGCHYAASKGGLTGMMKNLATRLAEYNISVNDVAPAMIGDTGMIPNAEAVPEVVKGIPLGRLGTPKETANVVLMLVTTGYMTGQSLLLAGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUB6</accession>
    <name>A0A370PUB6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_290564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUB6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="99" mass="11150" checksum="65F7CD248D6A765C" modified="2018-11-07" version="1">MASNQKVRRIVLTGAVTVITIAGSLYGAGIKTGQQVTQQAQKSQEVTIDDRIDGLRSMRQNLVSKKELVEKQLRDLDVKIEERKLKNMDGPKREPPNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV16</accession>
    <name>A0A370PV16_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV16"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="186"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="509" mass="57701" checksum="9C0C20941594CC90" modified="2018-11-07" version="1">MPCSRRRPPRQDPHNNSTSERVHHKRSKKMVAEHLTIRNLTSTPITLKRIERFRAPDRSLGVQTFAKNFTRVLTNTTRANTPVAAVNDDTKPFAEKDVDIHVAPFESVQTELRSFIESEKERLRWFFEVEGERHQIQTPVPTTETATMKALCDNPKFKLTGIYITAASHLTIFSSANLNAWMGELKDDTLLSSLSIPGTHNSPTCHVAAPSVRCQAVSPREQLRNGVRFFDIRVQPQYPEDTSKEELILVHSVFPVSLTGNKYFRDLMHEVNDFLEQNPSETLIISLKREGPGNHTDEQLSRIVNDHYARPGSRWYTEPKIPTLGEVRGKVVLVRRFEILEHLKDIHDGKGWGINASGWADNCASATCPSGQLCIQDFYEVMETTNIDKKIEYVTEQCGRACKTRYPFGVLPGPLATRAHPFYINFLSASNFWKVGTWPEKIAAKLNPATVEYLCRKHGEGDGDWSTGVLVTDWVGLDGDWDLVRCIVGMNSRLLHRQLMHAEESNGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV86</accession>
    <name>A0A370PV86_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1793-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_317251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016713166" evidence="1">
        <location>
            <begin position="24"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="106"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="332"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="689" mass="75379" checksum="9C9B37675CD48F87" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVB1</accession>
    <name>A0A370PVB1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_273223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVB1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="56"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="41230" checksum="1666A627C4895F23" modified="2018-11-07" version="1">MSFFIENPNVGDRCSLEDSRIRGYNPLTPPNLLQHEIAMTEKSRQTVMEGREEAIAIVQGTDTDRRRLLVVIGPCSIHDPEMALEYCDRLMKMKEKYKDELLIVMRSYLEKPRTTVGWKGLINDPDIDNSFKINKGLRTSRQLFVDLTNKGMPIASEMLDTISPQFLADCLSVGAVGARTTESQVHRELASGLSFPVGFKNGTDGSLDVAVDAIGSVKHPHHFLSVTKPGVAAIVGTVGNPDCFVILRGGKKGPNYDAQSIAEAKAKLTAQGMPPRLMVDCSHGNSQKNHKNQPKVAAVLAEQIAAGETAIMGVMIESNINEGNQKVPPEGKAGLKYGVSITDACIHWEDTELVLENLAQAVRTRREKLAVNGNGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVG0</accession>
    <name>A0A370PVG0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_98266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="247" mass="27271" checksum="E68785D3A080AC49" modified="2018-11-07" version="1">MALARAFTKRSKRPEVSAPMPYRESHKHAGPINRDKISAPVELLSTTNMLAYNAPDIHSATSSSTSSLQSPDDSEMSFTQRSFGSPLTTPDESPIEPNPLPSYFPKRSATVTSHPRSSTSTNSSTDAPLVPKRALSHTKRTHQELARQRSLSRLSPPPLNSLRNASAARQTQDSYKAEPHPFSKELEQVNEVVEEFGGTRILDDEELILRDKGLMKFTADDYLVEIEALYGSVFDDYLGPIGTGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVR6</accession>
    <name>A0A370PVR6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_273369</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVR6"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="363" mass="40774" checksum="1625AEA2932437ED" modified="2018-11-07" version="1">MQHQFEPLKNDLLLRAARGEKVQRPPIWVMRQAGRYLPEYHEAKAGRDFFECCRDPEVASTLTIQPIDRYAGLIDAAIIFSDILVIPQAMGMQVEMVDKKGPHFPEPLQSPDDGQYEKVMQKDVDVKSELDYVYKAITLTRHKLQGRVPLIGFCGAPWTLLCYMVEGGGTKLFVQSKKWIYKYPKESQALLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPAAFKSFSLPYLRHISANLPKKLKEMGLEPVPMTVFAKGAWFGLEDLCESGYNVVGLDWLHDPAEARRIANGRVTIQGNADPGVLYGGREAITEAVETMVRGFEKGKQGWIANLGHGVTPFVNPDDLKFFFEEIHRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW97</accession>
    <name>A0A370PW97_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_103054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="539" mass="59158" checksum="E351A25B543F1CA3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWE7</accession>
    <name>A0A370PWE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Catalase</fullName>
            <ecNumber evidence="3 10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_229264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:catalase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to hydrogen peroxide"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="53"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="727" mass="80329" checksum="651405F70FD312FA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX67</accession>
    <name>A0A370PX67_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_244807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX67"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="707"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="884" mass="97303" checksum="2A7ED373AA3E737D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXE7</accession>
    <name>A0A370PXE7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_272648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="162"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="405" mass="45899" checksum="42FB8D7E921862B7" modified="2018-11-07" version="1">MFRLPIVRAFFRVSPQPAIASSLLHSTRIPSHIPRSTPLTRRLSSRTRGTTSQAFLPSRRISGQSQLRSFSASARSRARYNRFNEPQFPKLQDGEHWQAWLALIAVGGSFYVYNLETVELTGRTRFNCVSDDLERQMGDNEYQQLLKRAEGMILPPSHYISEEVTRVFERLIAHTPVQGTNWEVHVINDMSQQNAFVLPNGKVFVYTGILPVCGNSDGLAAVLGHEIAHVLAHHQAERMSHSVPSVILTYGLVYLFGTFGHFASQMLDWSVNLPNTRVQEAEADNIGLMLMAKACYNPRAVVDFWDHMHKSERVRVPEFMSTHPSAFNRMQSMSERLYRAEALYENSGCHMVRGYIPEFTDAIDHYAGPQGRGPAIRNHHGRGHHGGVRHEQLQHGDSSDGEYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXN8</accession>
    <name>A0A370PXN8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_332234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXN8"/>
    <dbReference type="SMR" id="A0A370PXN8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="559" mass="59157" checksum="23739F23BF27E7D0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY54</accession>
    <name>A0A370PY54_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_64678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY54"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="334" mass="37722" checksum="E3B705D4EEEA9AE4" modified="2018-11-07" version="1">MPCKPAIASMSVGRAWVHSLPEKLSQIAQAGFKGVEIFYEDLEYLAKEKGEPTEENLLIAARETKDICDRHGLEVIGLQPFLFYEGLLDRDVHQQKIAKLHTWFKIVKILGTDIIQIPSNFQPDGISGDLDLIVSDMIEVADLGLQQEPPVRFAYESLAWGTYVSTWDTMWEIIQRVDRPNFGCCLDTFNIAGRVWADPASPSGTVPDADTLLAQSLDRLVKTIDVKKVFYVQVVDAEKMEQPLVPGHPFHVDGQPARMNWSRNARLFLYEQEKGGYLPVVEVARVILKELGFEGWVSMELFSRTMADPDPTVPQSHSQRGIRAWQQLAKELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYL5</accession>
    <name>A0A370PYL5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_72092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RDK47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370PYL5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
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        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L5"/>
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    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="175" mass="20169" checksum="F1A8A5EB3A9BBE8E" modified="2018-11-07" version="1">MSESKDKSANPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKISVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPGIGIYGMDFYCCMTRPGERVAKRRRCKARIGSQHRITQNETIKWFKNRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYN8</accession>
    <name>A0A370PYN8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_332547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="613"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="876"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="690"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1388"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1463"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK47306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1477" mass="162229" checksum="19756027E2BD199B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF8</accession>
    <name>A0A370PZF8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_72034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="150" mass="16666" checksum="DF954070E784C655" modified="2018-11-07" version="1">MAAAIKAINAKIRSNKALDYFCSTHFWGPASNFGIPIAAVMDTQKDPEIISGQMTGALVIYSGTFMRYALAVSPKNYLLFACHAVNFSAQLTQGYRYLNYWKYVTEWLFLPTLIEKHKDNADFRINSWGGREAQLAEAAKQGKDATEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZZ9</accession>
    <name>A0A370PZZ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_5107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZZ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="645"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="723" mass="80001" checksum="BE24C0DAF8DA8114" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0R8</accession>
    <name>A0A370Q0R8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_9221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0R8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="93002" checksum="6BEDAB010329AC89" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q102</accession>
    <name>A0A370Q102_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_316684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q102"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="486" mass="55751" checksum="F5CB6503E00526ED" modified="2018-11-07" version="1">MFAANIISYLAKLEPPRWIWAPILAAVFFWLLSAPSLKTSLPVINQRRRFEIGSLGSLKRFFKDAHGLVRAGLSQGSAFYLYSEFGPKIVLASKYADDFRSHHALSLLDAVAEEYHAHIQGFDPFNRDPAVIIDMVRMKLTPYLDWHDLELKPNMLDLISRLTSRVFLGEKLYRNPDWHRVTAGYAVHTFMSALFLRMFPRCTRPFVANLLPFCRKMRKELQEAKDIITPVVEERRTAKQDAIRQGKEPERYVDAMQWMEECAKGRPYDPTLAQISLTLATIHTTSDLLTQTLFYLAERDEIIVALRNEVITVLQGDGWSKSTFSNLKLMDSILKETQRLKPHNMVAMRRLAQEDVTLSDGTVLPRGSISVLTTEAMRDPTIYPDPETFDAYRFLKLRETPGYETMAQAVSTTPQHLAFGLGKHACPGRFFAIALLKIILCHILLEYDFKIADGWSPTVRKYGFIWQADPVAKVSVRRRKEEYTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3E6</accession>
    <name>A0A370P3E6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_287875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851892">
        <property type="protein sequence ID" value="RDK36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3E6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="62" mass="7027" checksum="6881C062527E8D08" modified="2018-11-07" version="1">MCPRHALTESRRCVQAMTASDGMSRAKARVLKREAPVLRPKQVNMMKNGEHGFDVKMSLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3K8</accession>
    <name>A0A370P3K8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_280487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851889">
        <property type="protein sequence ID" value="RDK36400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3K8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="266" mass="30795" checksum="6FF58C553EFD7019" modified="2018-11-07" version="1">MASTATSPSFQKPNSVTVKGFKISTQKLPILKADPIEEMTKELGITPPEMIFGDNFVAIEHEQSSWGIAFNAFDALDRVDKTGTSMLKVAYSREWQKSREKTHEGIKEIVKPFDWSYTTDYMGTVKPGSRPFVATTKPIPIELLKRPDPILFYDDVILYEDELADNGITMLSCKIRVMPSRLLLLTRFFMRLDNVLFRLRDTRVYVDFEEREIIREYQSRECDYEAVRRTLATTRDDVPAVMRDPNRLSEILPLVEKRLERVSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P464</accession>
    <name>A0A370P464_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_340354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P464"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496:SF1">
        <property type="entry name" value="ZEAXANTHIN EPOXIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="407" mass="45963" checksum="F66AF5E1437C81A9" modified="2018-11-07" version="1">MSTWRPGKRVAIAGGGPGAISTALAFIKRGYDVRVFERQTECRALGGAVLLSIPVLAILRSYGISLENFGSYTSTYFKNKWGKERALLPFNAEVERRMGIKGWQYGVLRSSAFQKMLDLVPEGVIFCNHEVTGYEEVEGGVKVKFKDSNTAPVTADILIAGDGIRSAVSRQAFGDPQLFHTGIRLWLAWCDHIPGIPANTGVISHDWQYQASFFPMLHDGKPGFEWWVVEPAWEGKQLPDDPKAHVEKILQGWSDPMPQLVEATNFDTQVYRWDIYNRPSMKKWSSGRIVGIGDAVHPVSPYAAYGMGMAIEDGYFLAKALDGVDLRDVKAVNAGFELFEEQRVDYVNHHMEFARFTSNMFHSLPWPLARLRDLVFDYTPFLKGLLQKEYLKRAEDETMNLKEFHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P469</accession>
    <name>A0A370P469_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_331116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P469"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="382" mass="41875" checksum="10C07DBFC440F365" modified="2018-11-07" version="1">MAPSLPELMLSIEDIKIAGSKKLPLKAREFYNSGSTTQITVTENSTAYKKYRLRPRVLVDVSQLDLRLNLFNQTFDFPLGLSPTGIQAMAHPQGELASSRASARRNIPMAVSSFSTYPVEDVVQAGQQLNPSATHTMQLYTFRDRALQTQIIRRAEAAGCKAIFLTADSPVLGYRYNETRNDFRTPEGLSWPMMGVSSEQLQQVTHDAGFVATNSDAHSWAKEIPWLRSVTTMQIWIKGVLTAEDVLLAREYGCDGVIVSNHGGRQLDEVVPTIDALPECVEAAAGKIRVHIDGGIRTGTDIFKALALGAECCWIGRPTIWGLAYDGENGVSRVLDILYEEFKRCMQLTGCRTLADVTPAALAVLRPDGPAAKLTSRQWGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5M1</accession>
    <name>A0A370P5M1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_224788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="56782" checksum="89B27C1699606B51" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6F0</accession>
    <name>A0A370P6F0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1777-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_241732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6F0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="28612" checksum="43395DEC477F6951" modified="2018-11-07" version="1">MTEPPAKRARRVDSSAMWDQDDRRTRSPELEPDYTRSPRRDHVARDDGRRDGPRDDRRYRSRSRDRRDRRRDRSRSRDRRDRDRRDRDGRGMRDRERSVSRDRHYDRRGYPSKGDRYRSRSPIPNGNRDRSRTPPPRGPRSDRRHDRRDHRGQTNGATDAKSGGNRFKDEMEVDSDGAVGEDDVEEMMRRSMGFTKFRSTKNTKVPGNDIYGVRKEKKTEYRQYMNRVGGFNRPLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6H9</accession>
    <name>A0A370P6H9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small subunit of serine palmitoyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_298336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6H9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13741" checksum="97C60E73021C7CBB" modified="2018-11-07" version="1">MTLFWILNSFMRWVRLKIYQYEVTFAVYMLTPTEKFIFNSLLLTLLSMIVTGIYVYLPDHIRSIYSHLYYYWAGERPFISASLPSISSVFRETGTQTLGVMYETAKNAAATATAPIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P715</accession>
    <name>A0A370P715_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_286866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P715"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="37333" checksum="61DC4BEBA3155CD1" modified="2018-11-07" version="1">MSLEADIDTSSIGARLARFGIVEAGLDYIRRLDTSFVAGGLAMATPGGAWQALAGKEGNHGKGEGARPPLSMKKRSHQAGTTAGSQHMVRTVPFLTGCSPKHPSTLRGSFHAVFSASQSPACSSRHPSRERWLGPSSRQSGLPGCETTDLLFRPIQVFKSEANSWSCRQPGPLVTHAPSLTIGNIQASRIHGFFYELVVRLKERYGNHECLDGQIVEVTVPWGKGVSSGIPTGMPVSEHSLGGLGYPPKWDKRVPPGSYAFCVDAALIDLICPVPCTGEMEDGGVCRSVARMLCRAASSNGNFASTATNYWLLISASGLLDLPLPALNSNRYMMARRWHGAKGDRSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7B5</accession>
    <name>A0A370P7B5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_279091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
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        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="964" mass="106959" checksum="0E5C9E77D6E170D3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7B8</accession>
    <name>A0A370P7B8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016597581" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="134" mass="14126" checksum="C35E47967C8655E4" modified="2018-11-07" version="1">MRLLAALYLPAFMASLTAAQSTPFEHTLLFPLANFHGSDGTAVASIGGCITLPGDAPIGSVRVASDEFCILYPYDCAPVPLQFINQLTKSRNNYCQGDTSQTISANVAQFPDSQTWIGISCSSGNPDSSDGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7Q1</accession>
    <name>A0A370P7Q1_ASPPH</name>
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        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_82194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7Q1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <end position="338"/>
        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK38209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="643" mass="72233" checksum="FF850EE05A2CF8F1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7X6</accession>
    <name>A0A370P7X6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_257079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="McDonnell E."/>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="7 8">
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P972"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="34219" checksum="E79F063C11AB9AB6" modified="2018-11-07" version="1">MSPSIPQVGWYGLGSMGLGMSLNLQRYLQAKNLPPLRYSNRTISKGDILRDAGAVPEEFDALVQKSNVIFTMISTDDVLIDLLERASTMGNSLKGKIFVDTSTIHPDTSEWAAKRLKEHGATFIAAPVFGASPVAAAGKLIFAVAGPVTVVETIRPLIMNVMGRSIIEMGEDVRKSSLLKISGNILVISFMEVIAEAQVFAEVAGISTQQMEKFIGNMFGSVLQSYSKRITSGAYAPPLDTAPGFAAALACKDMKHALSIADSHNVRLHTLETASKRLNTAREYAGENLDSSAIYGIARQEAGLSFWSANSRQQSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9D5</accession>
    <name>A0A370P9D5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_329606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9D5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016804323" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23457" checksum="E3E5F79F2590D2FD" modified="2018-11-07" version="1">MRGIDALAFLAAIGAAHGQSTVGFGPYFSLGPTQSWIREANTTLVLPEAPSPQKDRLALWPGMGTSGGDLIQALAVSFSDPNSNCGASSGQWCTWASTLEGTQLGGKEVPASAGDKVTMHYKYNDSTGKYDQTVSINGEVVSTLSTSSGQAQGWGTAVECQDDACQSTAGAHKYLDTTIILNAEDNSFGDTLSINEASSSGLSTSDNGKTWTVSTINIDSHTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9L7</accession>
    <name>A0A370P9L7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_286066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9L7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="41089" checksum="59F927497ACE943A" modified="2018-11-07" version="1">MTSFRMTYPILSTSNQAKAAIPSPAGEFREAKRHGLIAQLLCATRPTKLDSITWAYLWLADLLNLEELVRACEKTRLLTNCMHLGLSKSKDKTQVIDTWAVARPREELEKASEDEELDTDSEEPPTKKRRLALDQEKRPSVSEEEATPIANKLCTERDNASCVVTGCRDPVEIAHILPIGLGMKEAQETQTFWSQLYRFWSKERVDAWIKQARALEGTGACSNLLCMTDMTHKLWKKARFALKPLSLSEDRRSLEVQFYWLPVCKYRSRVSATEVPSRFPRKLSGTDVYGQETMLFSIATDKILCSGDILTFTTNDPNSHPLPSMELLDMQWVLNRVLALSGATYATDKELYDNYCEDDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9M1</accession>
    <name>A0A370P9M1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_74513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9M1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="468" mass="48706" checksum="38A68D71FE8842B0" modified="2018-11-07" version="1">MSASPSALQSTKRPLEDPSSPSGPNDQPEAKRPALDKVVKGDESEAYADVKTDAPAATADGQGDTVVPDAPNSKGAQETQPIQSTASHAESTGAQSEQHRPQDESSWIHIRAVISSQEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGPQDAAAKAFGLIIRTLNNEPLDAPSTAQSKTYPLRLLIPHILIGSIIGKGGSRIREIQDASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPDTFKRHHPHPNRGAAGGYGVPYLQGPAAQTPVAQPSMPYGATPHTPYAGAGPHQPAPYGAPQAAAAQARGGPTPAAPVGGVMPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQENSNERLVTITGTQECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9V5</accession>
    <name>A0A370P9V5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_75662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9V5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="365"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="718" mass="79192" checksum="44A8B991785DB2A6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA58</accession>
    <name>A0A370PA58_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_269199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA58"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="263" mass="27397" checksum="0EAF2B5B8A5539AF" modified="2018-11-07" version="1">MSIDLTGKTCLVTGGAGGLGKAIATRFFSAGANVVVCDINEERLRQTSLDLAGPSGDARLKVIKTDITSATEVQALFDEIVAKFQKLDILINNAGIMDQFDAVGDLDEKLWDKVMAVNLTAPFLLSKLAVRNMLAQDVVNGSIVNIVSIAGKAGFMAGAAYTASKHGLVGLTKNTASYYGNKGIRCNALMMGGMETNITDAFMSNINLEGKDKAVALMTAAAAPMCDINRVAELCLSISCGPGAEIINGTCIPIDHGMSGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA7</accession>
    <name>A0A370PAA7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">High osmolarity signaling protein Sho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_59980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="311" mass="33387" checksum="CE1BD43AA27C77D2" modified="2018-11-07" version="1">MVAYSSRSPSFQKPYTYPEPPRKMARFRASNILGDPFALATTSISILAWLIAFISSIVTGVHGGYPTYSWWAVAYSFCCIVGMALVFGTDTGAVYNIAIVGYLSAGLVITTISINTLVYANSAASQAAGAGFILLAMVIIIWIFYFGSSPQASHRGFIDSFALQKEGAGSYGNGRPMSTAFGNRPETTSSQPPQMYTSAQLNGFETSSPVSGYPGGAPGSEHRSSSQPRFGNPSATNLPNNGAPDEVPQPTEYPYRAKAIYSYEANPEDANEISFTKHEILEVSDVSGRWWQARKATGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAQ3</accession>
    <name>A0A370PAQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_338161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK39263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="443" mass="49020" checksum="19C9E5E3FC8DF803" modified="2018-11-07" version="1">MAPSTVTHDSTILVVGAGVWGCSTALHLARRGYKHVTVLDPYTVPSAIAAGNDINKIMEHKEPKAGEESPRSIAFATCTRAALKAWRTDPVFKQYFHETGVIVSGHTPALIEHIRKDEIESSDADFVELKTAEDFRKTMPPGVLTGEFPGWKGWLNKSGAGWIHAKKAMISAYTEAKRLGVNFITGSPQGNVVSLVYENGDVVGAKTSDGVIHRADQTILAAGAGSDRLLDFKKQLRPTAWTLSHIQMTPEEAKQYKDLPVLFNIAKGFFMEPDEDKHELKICDEHPGYCNFIPDPARSGEIRSIPFAKHQIPLEAEARVKDFLRDTMPHLADRPLVFARICWDADTVDRAFLIDKHPDHPSLLVAVGASGNGAMQMPTIGGFIVDALEGHLQDELKHVVRWRPETAVDRDWKSTQNRFGGPDAVMDFQTVGETEWTKIKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBD8</accession>
    <name>A0A370PBD8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_238896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBD8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.40:FF:000001">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="416" mass="46895" checksum="481E88599621FED1" modified="2018-11-07" version="1">MTVGAFSEWRKLPVSLNELCINTTLRCGQSFRWHNVPDTDEWRCVLHGRLLSLKQDPTHLYYRTYRTAQSPKPKINDDDTTLSLLTHYFNLSANLTSLYTEWSAQDPNFRKKAPQFTGIRILRQDAWEALISFICSSNNNIARISQMVEKLCLNYGPFIASINGRAYHGFPAPDALTAHDVEGKLRGLGFGYRAKYIYQTAVMVAKERESGWLDSLCNPECPAWGVETAPAGEMKPEGREGYREAHEKLLELQGVGPKVADCVCLMGLGWGEAVPVDTHVWQIAQRDYKFGKGGNKSLTKVTYDAVGNHFRKLWGKEAGWAHSVLFTADLRTFSDRLAATTSKKVDVKVEKDDKEGVEVETKVTTAIAVPTKRPIDEEGVKAEEEGETKEKEELNTIVQASQTTTTRRMSKRLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBI8</accession>
    <name>A0A370PBI8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_50275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBI8"/>
    <dbReference type="SMR" id="A0A370PBI8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK39555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="321" mass="35105" checksum="456A68BE60D3005D" modified="2018-11-07" version="1">MSAGGEHLKDEGTRRQVVLAGGIAGLVSRFCVAPLDVVKIRLQLQIHSLSDPISHRDVTGPIYKGTLSTMRDIIRQEGITGLWKGNIPAELMYVCYGVIQFSAYRTTTQALAQLDTYRLPPSAESFVAGATAGGLATASTYPLDLLRTRFAAQGTDRVYTSLMSSVRDIARNEGYAGFFRGCSAAVGQIVPYMGLFFATYEALRPPLAQYQDLPFGSGDAAAGVIASVSSKTVMFPLDLIRKRLQVQGPTRQLYIHRNIPEYQGVFNTMKLILRTQGIRGLYRGLTVSLFKAAPASAVTMWTYETSLRLLQDMEVATSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PC07</accession>
    <name>A0A370PC07_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_296182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PC07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF2">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="195" mass="21531" checksum="BC97FF81CED27BCB" modified="2018-11-07" version="1">MLVNKVPPETLTVPPTAHSPNSTRPVLVYRNALIDKTPQGAADAIEQSEWIYGGHWIIAENTLAAVPHYHSITHEAYTVLHGTGTYRLGKSSLDPGFDANGEEVGVVFTARAGDVFVFPAGVTHCVTSTSDNYEIIGWYSLNDKNSRAQPWDYEEALDSPEETNRKRLICESVSTPVLDPVYGKEGHLPIVWKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCY9</accession>
    <name>A0A370PCY9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1770-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_337801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCY9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="184" mass="20681" checksum="D51C35FAE666719D" modified="2018-11-07" version="1">MTDPALQIPEVIQTASINPAPSPEHDVNPPTAASEKQPIVEDDVASEAGSIPSDVVDPHRMIKPVSRRHHLPPLPDLRFEQSYLASLRGADTWGRVAWITIRDQVLLPLIQGTVWTLALSGWRFWNRNASLSGQTLGSKIRRWWYEVNNWKLPPLRSARDPHMAAKVEDFLQFYTAQFSNAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDA6</accession>
    <name>A0A370PDA6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_303693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDA6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29037" checksum="2541CB33D7C72473" modified="2018-11-07" version="1">MLNRLTPETTREAAKEIIDGVRVSTDWFSTSMQKPCFGRPKLEHVVKNKAPRAISSQWDGFRHYGYQNEKIYLNGLWVENGEIVGRGVLLDYASWAEEHGIQINCFSTSSISVSFLKEIAISQGTTLKTGDILFIRTGWTHAYEKLSAEQCQELASVKVPPALGVESSEETLRWIWNEGFAAVAGDMPSFEAWPCQNTDFWLHEWVLAGWGFPIGELFDLDRLSQECRKRNRWSFFFSSVPLKVPGGVASPPNGVAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDS1</accession>
    <name>A0A370PDS1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_277649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDS1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="538" mass="60269" checksum="AC6108C460C40DCD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDT7</accession>
    <name>A0A370PDT7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_304001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDT7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="449" mass="50942" checksum="3F894CB90D9189C7" modified="2018-11-07" version="1">MAGLTIPPSPPSSTTGASRLEARAKEIVEKIFGIAVDGVERAPILDYNANTISYEVYFLQTMWSLLDAPKQHGVVRMPSGSRQLVIQFKIPEGNMDQGRWAENKVAAMYTARTILYNTLYLHTVPEVYAWSDGSDDEYNNAWIIHSSHPPGDAPLKQSFYEMSAEHQSEILGQIATIHKLFQSYDHMVVCQGYGGFRFSEEGYVRSGEALMTGVGGPFPNLGSYLTEMLRRDLRRAEERQDIEGWRKSPELRSRLEEFVEQSVKDVVAEIPEYRPTFTLNRIELGNFLVSQRPDQSPIISYILNWNYASLGHPLEEFIYSYNSLHGALLFPMDSDSIVMYRCILEGFPDGDVEIDLRDLDKYAYYDDGMSAQSQYNLARNLYEALQIAEVDRPQDIEGAKKLVVFLGFCAAVGGRGLYRDDPASNADPDEVYQDKAKQVEEYMKLLGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE86</accession>
    <name>A0A370PE86_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_33125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE86"/>
    <dbReference type="SMR" id="A0A370PE86"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21029" checksum="3BCDC54FD15EA848" modified="2018-11-07" version="1">MATDHKSILVPPKRANTDYPLIDSDPHLRRVFGYARPSDYAVGGGMAAASPLAFWIMERVSPSHVGRGGFAPVMRLATAIGLIGGLHVVYQRSCNRFYGFTENSREADMDMKEMVDKVKKGESLYGTSKVSSYLQGVAARNSRYSELFIHVLPWFNLVNHDQHGVDTAKYYQQAERELEAERLKQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEH3</accession>
    <name>A0A370PEH3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_34568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="51" mass="5686" checksum="DD435C9344EE8625" modified="2018-11-07" version="1">MTGMSEMQESRSLFTAPAGAAVRAETMAFPSLRSQNCHEQSRTKFHRSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEQ7</accession>
    <name>A0A370PEQ7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_337179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEQ7"/>
    <dbReference type="SMR" id="A0A370PEQ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="153"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="349" mass="37848" checksum="C75F06CCD9F0C6A3" modified="2018-11-07" version="1">MQPVAHQSGGASGDPLPPSLPTEAIEEKASVSSLGSWNHLVAGATGGMVTAIVTSPLDVLRTRLQTDYYQTQGVNRSIPTHAHVRQSFVRTSIRHFRETFGILFSIHRVEGWRGMFKGLGPSLTGVVPASAVKFYTYGNCKRLLPEILGCDKDTTLVHAMSAACAGIATGSATNPIWVVKTRLQLDKAGARRYKNSLDCTKQILQQEGPKGLYRGLTASYLGTIETTLHLAMYERIKGLISKEVNLDKNSDSNKFVQGLALSGASGLSKLFACLIAYPHEVIRTRLRQAPMADGRQKYTSILQCARLILKEEGVIALYGGLTAHLLRTVPSAAITIGTYELVLKVLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEU4</accession>
    <name>A0A370PEU4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_267778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEU4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="339" mass="37766" checksum="110676CE4CA6F51D" modified="2018-11-07" version="1">MPAQMDALGAFTHLTENIPSWIDRLAELSAHTAAKHAEYAEAYRRHVSVRPRRRKNSSVCSIRTEDLRSSAPETETRPQSSAAATNTTVTTPSTSQHEANVNPRKRGAEDAPSMEARDRDLLVSTRNNLIIHYDGHTQHVLEEMVRHIGTARNNIRKGRMTQLPLPGYRSKMLDRSARMNSLAPSLSPSESGEDDVLSSIRKARNRGPPVPRAPEMPRESPFDMAEKQLELVHGVCETAAYQFLRSGDCSTELSSVEGKFKSLLDLATNEVRRLKAEQPQEPTVEEDETEAPAMEPATTTIEVDRQSLSKMDTIEVDDSAQSVESIDLTAFRANRLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFX3</accession>
    <name>A0A370PFX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_294729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="188" mass="21166" checksum="0A1C6516B5AC9813" modified="2018-11-07" version="1">MSSSYPRQQPRQTDLTIPDENEPSPAQLEDVTIPIPAHMGCSTSPDPKTLSSGRDPVTPSPTRAALDQDAIRPATDLPIVASARIHAKPILLPSPIPLGTSRSPSITVTNWNAYARRNAAARILTLQLINCMDNDDKLHDEVTSWYQEFRFQIWSPLASMISLNWRQVEQLCWQMEKKEIIRRATKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG69</accession>
    <name>A0A370PG69_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_217574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG69"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="557" mass="62391" checksum="742814B5D5F82785" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGU5</accession>
    <name>A0A370PGU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_276885</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="517" mass="58049" checksum="27BEC83F79998901" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGY3</accession>
    <name>A0A370PGY3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, amino acid transport and metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_276904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGY3"/>
    <dbReference type="SMR" id="A0A370PGY3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="195"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="64245" checksum="6A26BC4B88602CCC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH22</accession>
    <name>A0A370PH22_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_27688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="586"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="951" mass="107563" checksum="A5F0650A1FCD40D6" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH45</accession>
    <name>A0A370PH45_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_216684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="30"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="413" mass="45741" checksum="84A6A326FCAF5281" modified="2018-11-07" version="1">MSEQYLGLPIAPADTAFGLMAEYDADQHPDKVSLIAGAYRDQNGQPWVLPSVREAKALLARNQNHEYLGIAGSPALISLAQSLTFGSEITAKLEKSIASIQSVSGTGANHMAAHFLAHHLRPKRVFIPSPTWINHKTIWANVGVPIAEYPYYSTKTRGVDLEGMLSVFETTAGERDVVILQACAHNPTGVDLTHEQWAQVAEVMKRKKLYVVFDSAYQGFATGDVDGDAWSIRFFVEQLILNGQPDYPGLCVAQSFSKNFGLYGERVGALHLVVPRHLGAQGARSELVALARAEYSNPPRFGASIVEAVLGNEKLKGQWLRDLDTMSSRIKNMRRELRRRLESKETPGDWSVLESQIGMFSYTALDQEQVTRLREKFHIYLLPSGRVSICGLNEKNIEYVASAFGEVIEFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHZ0</accession>
    <name>A0A370PHZ0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHZ0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="268" mass="29835" checksum="E61E6EDAF85793DF" modified="2018-11-07" version="1">MPLTYSTIPLKVNGVRLEISTIHNNKLNSNPPIVFLHGFGSCKEDIADIIVHPSFQQYAYLAFDAPGCGHSHTDDLSVVDIPFLVATAEAVLAHFGIDQFHLMGHSMGGLTALLLAHRLPDRVLSFVDIKGNLAPEDCFLSRQIFQFPADDPEAFMDAFIVRTETAESYASPLYASTLRARVRSGAVRPIFESMVKLSDEEDLMGMFLGLPCRKMFMFGEENRGLSYLPRLEKEGIELAMIAESGHFPMYSNPVEMYRRIAGFLEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI01</accession>
    <name>A0A370PI01_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_336219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="245" mass="27674" checksum="7D4CAE6D283F4F71" modified="2018-11-07" version="1">MMVDPFEVRMRFTAQLQHLNASVTSSQKAAHYALKYRDMDEDLHSCILEQLERNNMNNRANIMYFIEQFCDMATKEDHAPYVRMIQRDILRIVDCVAPADGSGAANVKHVRRVLNGLQSKEILSAETIAEIDAGLKDRETHPAHLDLEAEEGGGGGDGGGDARAKHGTPRGSKSSGMRVDKRQIEQRIEEDRERNKRLRESMWTVSGDDGDEHGKFWDEASDIGEDDFLAANEEVMERRQMIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PID7</accession>
    <name>A0A370PID7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PID7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="291" mass="31539" checksum="6F7A013657EB6EC8" modified="2018-11-07" version="1">MKPDVTTTVVTHPETFDIGLSPTGDAGSAFHTQNDPSAPYQRENYIERKTAVDIRCSCVDVVHGLLSPDGSSYATLIVLQFRFDPRKRARRISQVDIELQFSGSEPGAADPEVYAIAPNEHLSVSRTTQTETTSTEGSLTLGAGTVVSNFVDASSTVKYGHDISREMSYAATIVGSIDLRGRNYGKANCASWTLIENPATKAGVPAAMRAAILLKRKDEGKFQADVSIRAKADWKTQLEWLVGSTRADDPVLFDPTLSPTSDKYDDMELKMGDIDLKGISEVVVESGKTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIG6</accession>
    <name>A0A370PIG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_327340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIG6"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="374"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="723" mass="77464" checksum="444B16565D86EFF8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIU0</accession>
    <name>A0A370PIU0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_293796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIU0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29239" checksum="CD67AAC0FCD7E502" modified="2018-11-07" version="1">MPPKRKHSSNGPEQRSEARNKPYAYLKPQVRQVSERTIKSKWSTLPEPVQDRVRDMFRALERPVIVRQQNEGKRIEAQAAVQAVVKNLGKRLPRMPFPPVTKDSVFEYEAALKEHCSLEATLATVTDSIDLLKAEVEKEEAMLEREKKQLQEMERNAKRAEAERKRQSKNEHPVLRQVDSLPDEYNQKQTEFTLAGGKETQTMFDELENDPEVSNILKQLTGHLKSMQNNTAPVAGLKDAIGRSHAALSLTFMPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIU7</accession>
    <name>A0A370PIU7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_301539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIU7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="446" mass="49329" checksum="EFE987FAE6F708D9" modified="2018-11-07" version="1">MTYEENRYWKNVLTIVPIIGAALATVSYVLRLYSRRFTTAGLKVEDWLMGVGLLLSYCATAFVVDTAFNGVGLPVSSLPADERQRIQFGSWMIQKFWAPSAAFVKISIVVFLKRLLGTVRAYAIISNVLIAFIACWALTALLVNIFQCTPVQYYYNKDLKGHCMSGQRSFFQAMGAISLVEDVIVLCLPTPIVWGLQITFRQKIAVTLVFSLGGLVCIFSLMRLIEFRTFVTTDLASSSAKESVWTCLELDVAIICGCLPLMKPLIQGFLGKVRSGVSKARSHPSSGTKLYFPNGTTHNNDGFRQINDPLSSLASKNAHIAANESRRSSDVELQGIAVTTRIDQDVDRPRTGNSTDISADHDDRRFRAYKQCSSLPNKKGYPARLDEGVSLHPDPSTVHSSDTRDLACVVHAGSRNMVSWDLVPARHLRGNNGDERVYCSSATHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIV7</accession>
    <name>A0A370PIV7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_294100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIV7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41560" checksum="7A07F974D2A30F5F" modified="2018-11-07" version="1">MSSNLSGELLPRHGSHDARGQDTGMSIQFYNVFAYPIVRDQLIANTVLVALSTASIGLRFMSRKIRQSKFWWDDAFIVVSMLHTYGMLAMQYHYARVGMRHHVTELPAMNTILIFKMLIVYQIVYYNAMVTAKFSYLFFYLRIFVTPGFRMAARVCMGCAGAYWLGSMLQVFLICQPFAKNWDATLPGHCASMNVAFSTIGAFNLVTDLLIMALPVHHIWKLQMSTGTKVALYGIFGVGLFISAITIIRIHVLTTVDFTDLSYSMIWAAFWSVTEPALAITNACVPMMRPVFKAAFPGVFSSAKNAYSSQTGAQSGASGSAFKRMRDTESEMPLTHLEPTKSGSRGVEYEASLNDRSQDEHMPRSVIGESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIZ7</accession>
    <name>A0A370PIZ7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_20815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIZ7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="25413" checksum="B774F6B928A2B117" modified="2018-11-07" version="1">MAPPRQRTTAAQDDSRSEGSSTAREHKTTTGKSRKGAGGAAAVAALNSREAKASAISANVTSAPAGGEQDNLPKIPWSDMPLELLHSYRHAYKLSTPSAFASEYSHLLLSRGIGLRSPTSIAAQRAHLARQDQTTNGSQSSASTSRKALQSNSSAPNGVSTRHKDRPSNKGPDTIDTKGALHHIIGQERVCKNQLAVTVRKHFNSAGLAEQEAIARFLYKVREEGRGRHFRLRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ06</accession>
    <name>A0A370PJ06_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_301641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="292" mass="31976" checksum="43C2AE37B065D802" modified="2018-11-07" version="1">MSKKLTVLITGCSDGGLGSHLALQFQAAGWRVFATARNLSKLKEAKKSGLEILHLDTLSDDSIYKCVSEVRELTGGSLDALVNNAGAGYSMPVMDVDIQKGRDLFDLNVWSIISVSRAFLPLLMRSTREGGALLINHGSLSGTIAATGPFAGVYNASKAAAASFTENLRLELQPWNVRVINLLTGAVRSNFHVNAPRPELPPDSLFNIAKDIVEQAMDNSDDSGDTDPATWARQVVQELSKRSPAYWIWRGKFSTLVRLGNILPLGFFDRIMKKMVGLDVIEQRVKRRRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG2</accession>
    <name>A0A370PKG2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_250570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKG2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="245" mass="27420" checksum="29C08ED73FF5B219" modified="2018-11-07" version="1">MTSLPPAQCCIAGHLHSGTPKGELKKIDDILTYVSYPPNKSTQNAILFLSDIFGPKLVNSQLIADQFAANGYFVVLPDLFHGDPVPVEREGNFDVMAWLQNHLPPVTDPVIDRTIRYMRQEQGCQRIGGVGYCYGGKYVARYLKPGLLDVGYMAHPTHVEVDELKGIQGPLSISAASSDYLFPTEKRRESEDILSELGHPYEITVYSHVEHGYAVRCNMEIKQQRVAKEKSFAQAVGWFDAYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKH4</accession>
    <name>A0A370PKH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_233441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="473" mass="51908" checksum="45D8B5700819140F" modified="2018-11-07" version="1">MREDTSDKRAAETVVADQEVESGLPSAYRPTRWQSNLTILSCYIANFSDGFQNQLANPTNVIFKKLLGKSGYPSEMQTRISNSLLIGAILGVVVLGYVSDMASRRAGLLFTSGLVTISTLMATLALQVHPSHNMLWYFVIVRGICGFGVGGEYPPSAAAGLEESDDFKRRYRGPVFVSFTTLMATTASPILMIIYLICLKATNNNLPITFHAIYSIATILPAIIMVLRFFMTDSTLYHHSNFKRQRKPARFYWVLVRRYWKRLFTTSLAFFLYDFINFPNSIMSSTIISSLVKDGNIQTTAIWQVILAALPVPGVIIGAWLTNLIGRRGTGMVGFAGYVVLGFIIGGTYAKLSQHIAAFVVLYGLLQAFGHLGPGATIGLISSESFPTAMRGMGYSVATAFGRTGAAVGTQCFTPLQDAAGDSATFYLLGGVAILGMIVYWFLPESGKLDLEKEDRELEEYLAGHGFTMEKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKJ3</accession>
    <name>A0A370PKJ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_160742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="255" mass="28045" checksum="BA8BDA1BDC0845C4" modified="2018-11-07" version="1">MALIEITVISDPVCPWCYIGYRRLTKAIRLYQKTYPGGSQDRICISWKPYFLDRDAPMESVPYIERMTQRLGADKVPAAKARLERLGAQEGIYFKFGGRFGNTLRAHQLLLLSEFVSRQGKIDGCGARDTATAVAEGIFRAHFEDELDITDVETLVRVAVHASEGYLDEAKVRSWLEQGQGVEEIDDMATRARQEGVHGVPCFQIGGGENAEGAVLTLSGALDVDEFLQALIAHKTGKGLDSADKVLGGQEMTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKM7</accession>
    <name>A0A370PKM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_315080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="556" mass="60678" checksum="7ED004E0550BA1EB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLK8</accession>
    <name>A0A370PLK8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_335795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLK8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="285" mass="32590" checksum="B87404C53E16E1D8" modified="2018-11-07" version="1">MTAPDSENYQIFRDCVSSAIVAKFSPTPRTKKARRPRTTPRQKSSSRAEPKPKPEPEQPQQNEFTKTDPEDLADFIDRGRERESGVSPSSPSPPLSSPIKQFIATETFPSLQPPTLQTLSYDPNTDFTSSKEYSPQHLAEKTSHTLPASITDTLTAYALIESASDIPYFLAPILGEYVASVTKPPPVWATTRTDACEICERDWIPLSYHHLIPRSVHAKVVKKGWHEEWRLNSVAWLCRACHSFVHRMASNEELAREWFTVERICEREDVRDWAKWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLM3</accession>
    <name>A0A370PLM3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_276184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="443" mass="50407" checksum="8AB0B4729AC42E47" modified="2018-11-07" version="1">MDSPAVPAPLDPKEQPILERLLRTRDALILLKQDKSSYIKSRDVLPLYEEVVAEVEKLNAARKEQDRRRAHNRLDYVLDDCFQLISLLFLTVGRNNEAPAVYSLATTVQRLLDHLEEAGFYSSKDLISITKTLANMNETLDRCRQAYSPALITLLESRLEKCQLLLEKLQSGLAKLGPELAATHETLVSILRSTSAVNTRSKFSSSEVTTLRTQLKKIEEGMKDGQFVDAEGVPLPGAQQDVKLLMERCWLWTEIVLERQGKIDERFKEQYDRLIEIRNQLDRLAVTQAWSLRETDLFGYQRKLDRIDEARVNGNFVDAEGNAADIHAQRTLLYLIRRSYGYIYALLISSEPVSEALLPVYNQLQTLRKCLLEVQESGGVSNSRELYPYSMKLNSIDNMRVDGKFYVGTDIPEGQGSVNALLAECYDIVWELRAAVDEDERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLY8</accession>
    <name>A0A370PLY8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_275468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLY8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="365" mass="40539" checksum="74083A90883C9664" modified="2018-11-07" version="1">MAQSATLFKPPPLDSTKAPIENVLELTPVIDVGKDVFTNTRPLWHPPGARGIYGGAAIAQCLAAALRTVPADFAVHSMHCYFLLAGDSEIPILYHVERVRDGRSYITRTVQAKQRGRPIFTTTLSFNKANSGGKKKLEHASSMPAVTLPEEPGPGSKRKFEESGGGPFESQRAGVVDRNLPPQERKTRRFMRSRGKISDAGGHQAHLSALAYMTDSYFIGTVSRVHNIPRFSSPEELKKALNALKNPSDLDDEDIARALKELKEEEAADLRRRLEGALHRVTTQPPQEHKEVGMMVSLDHSIHFHNPWAFRADEWMLTEMESPWAGEGRGLVLQKIWSKDGTLIATCTQEGVVRLKQDEPPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN61</accession>
    <name>A0A370PN61_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_275796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN61"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="120" mass="13777" checksum="9C5BCA4DAB4BFDF9" modified="2018-11-07" version="1">MSSSNTTTTKKPKPKTQPQSQPQEERPHLSANFANPSSQRIDYDHEVYLHLMSGDDGDDTRKDKNRSKTPNQVYRENIVRRHTTRALDPAVVDPNAQRDPSPLDLEWAESQRVRERLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNJ3</accession>
    <name>A0A370PNJ3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_275678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNJ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20275" checksum="83F8BA3A1FE2C33D" modified="2018-11-07" version="1">MIIYTDIVSGDEVLSDTFKIQEDSDSKLLWTCDCRKYLKKKNEDFELEGANPSAEGGDDDAGGEGEAVMVHDIEDQFRLVWLKTEEGMKPSKDAFKSHLKNYMKKVLARLTETGASKETIDEFKAGAPAAVKKILGNYDNYDVLMGQSMDGDAMHILIDFREDGVTPFATLWKHGLQEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPA5</accession>
    <name>A0A370PPA5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase III transcription factor IIIC subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_249078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPA5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="197"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72050" checksum="E0AFFD411B88F43F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPG2</accession>
    <name>A0A370PPG2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_275310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPG2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="51" mass="5542" checksum="650D0B2E861E66AA" modified="2018-11-07" version="1">MAGARLKPYPPCDVYNVGKSGWQGLYVSRADFPGIPQHECALAARATLFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPI5</accession>
    <name>A0A370PPI5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_275347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPI5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="44458" checksum="09152E0CF889EDAB" modified="2018-11-07" version="1">MGSVAPSPAELDASVVKVTRSTNLRDVPLPGSPEELSHSHCTDHMVTVRWTVANGWETPEVRPFENLSIPPTASCLHYATECFEGMKVYRGFDGKLRLFRPDCNGERLMNSAKRSSLPSFRYEEIKRLIAKLMQIDGPRWLPKDQPGRFLYLRPAMIGSGPHLGVQTPKEALLFIIAVPWPDPSKKVSEQPGVPSGLKLYASQPDSIRAWPGGFGYAKLGANYGPSLLAHGKAQELGFDQVLWLFGEDRQVTEAGASNFFMVWENKETKKLELVTPSLESQLILPGVTRRSVLELARERLTQSVGKLAAVDVVEKHFTIGDVEEAWKEGRIVESFVCGTAFFVTPVKLIRNGDVDMNMQEAGAERAGYAAQIKAWLEAIMFGMKGEAAHEWGYVIDGEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPM7</accession>
    <name>A0A370PPM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK43864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="36889" checksum="8E91CD28F4424FDA" modified="2018-11-07" version="1">MASPQTTTPLPVVAIAGATGHLGKHVVSAFLASNLRNRFSEVILLSRQDSHQHPPTGLPTPSNSTHPKLTIRKYTEDDPASITRALHGASILINTVGPSGHSFKEKLLHAIPQTSIQLYFPSEFGVNHYVHDFPHLEWDAKKKHMALAEQLLTQGPKKVKICRVFCGLFLEDSIGPWFGFDTKRGRYESVGSSRVPVSFTSLGDVGRSVAALASLRVDEVPEVVHVAGDSRSVVEIAEVMGGAGGGGEDGNGEIEVVEVGLEEYKRDVTTGKKDSWDPAPYLRFLMGEGKIMHTRDGLGDDDELVNPGERLWKWETLRDLAERTGGRPWGDYAWPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ15</accession>
    <name>A0A370PQ15_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_291443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ15"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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            <end position="513"/>
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            <begin position="434"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="RDK44278.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ41</accession>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
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        </location>
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            <dbReference type="EMBL" id="RDK44313.1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
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                <person name="Theobald S."/>
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                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
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                <person name="Tsang A."/>
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                <person name="Andersen M.R."/>
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            <strain evidence="3 4">ATCC 13157</strain>
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        <property type="match status" value="1"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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            <end position="165"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="262" mass="27522" checksum="7B97BCBBF38F74FD" modified="2018-11-07" version="1">MSESTSTNTPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCSLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPSSLTKAKHWVAELQRQASPGIVIALVGNKLDLTNDGNEATGESPADAEGESSTADADETAEEPQEAQDVTSGDARKVPTREASAYAEEEGLLFFETSAKTGTNVVDVFTAIANAIPESSLKSGRAGGAGTGQTSLNSGRPAEDSRVNLGERGPATAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQQ8</accession>
    <name>A0A370PQQ8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_291670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQQ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="714" mass="79542" checksum="5B16E109DB6E5785" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQY9</accession>
    <name>A0A370PQY9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Forkhead domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_142272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQY9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="450"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="753"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="753"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="831"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="971"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK44599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119107" checksum="9FB0747E64553324" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRF3</accession>
    <name>A0A370PRF3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRF3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="8858" checksum="B5E7E64DB0D3B7A7" modified="2018-11-07" version="1">MTTNHYTYVPAPTGGRKLRLFIGDPNRVRGYEVVIRQRVSRRPQQQQMLDINSSSSSSAILARSNHPSSVARYQPTVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PST6</accession>
    <name>A0A370PST6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_133708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PST6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="77" mass="8515" checksum="1019E1977422CB57" modified="2018-11-07" version="1">MRYPIFRLHGLYLDSFRSSSSKLLCLTFLILSTSCHTMGGLIWGVVPRGGDPVCCCSIYVLSVHTTSKAIRNDAGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PT39</accession>
    <name>A0A370PT39_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_246604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PT39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="31364" checksum="CFCAF749293714B5" modified="2018-11-07" version="1">MSHSPPSPSPSPSPSPPFRPYRPPPPPTNNHNHTTTFDTSILPNGSKSLSAISIRAYLLGTVLGVSTTLTILSLLYDPLYTPLWRIPFFLSSLSLFHFLEYYTTAAYNTHFATVSAYLLTSNGWAYNIAHGSAILECLLMHTYFTARPVPLYLPSSLTTYQVAVGLLLMVVGQTIRSVAMAQAGSNFNHTVQVTRREGHVLVTGGVYSVLRHPSYFGFFWWGLGTQLVLGNGVCFVAYAVVLWRFFSGRIWREEKFLVAFFGEEYERYRKRSWVGIPGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTG9</accession>
    <name>A0A370PTG9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_273771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTG9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="318" mass="34870" checksum="92C7F21E2E715CD9" modified="2018-11-07" version="1">MAPTILIVGATGNTGRAVTETLPTLLKANENFKNHRVLALTRSLTSSSAQLIAKIPGVQIIEKNWTDITSDWLREHEVVRAFIASHNAPNQFAEESAFHVAALGAGVEYVVRISTTAPNVRPDYAAYYPRSHWAIEAMLGSAEFSALKWTSLQPNVFLNFYMALVAEYIKQYKRTGELGPLKLMASKDAPVAPIHPDEVGVFAAHLLALDNPSPRSGAKYVLNGPEDITGEQLVGLVEQHIDTKVKDMEYQDLSFLDAMLGSQYEGSGESMTVIKSIKYAPLTMWEGKCNASTTSKEVLDIAPPRRTPTEVLEDLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTH9</accession>
    <name>A0A370PTH9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2 type zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_311585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTH9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39169" checksum="2F7E7E6B2D038B9C" modified="2018-11-07" version="1">MPPKTYWCQAPGCKASYQRKEHLRRHEAQHTQHQLRQCTACTQKFRRSDTLRRHMQNVHGVNDMPDSKHACAHCRKQKSRCQGGPPCNKCLRRGIHCSLERRAEPHPADRPDPPRMLQPPPAQPETEDSDQESHYIGIYFNVFHPRWPFVHQGSFGNHEAPLLVKSMLVLGLWMSKQRKAQSKAIELHNVLGLAIRQQTDAWDASIADATSNCKWPISTYQAILLHIIFAGLYRGGGELDLDLKPSLAPADADLLERLVYIAWVFMDKEEGIIIPGTTSGRLRACDLQFPPPKNTPLWNAVTKDEWESAATADMDRHGIYDPLPQEWISNSADIVELVVTGFPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTL8</accession>
    <name>A0A370PTL8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_311630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTL8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="171"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="419" mass="46561" checksum="A8CF0358BC7B69B3" modified="2018-11-07" version="1">MVGQTFVRDTPSKKLSGAAAEAAAKVNKLLLHDFTVKVNNNPSTDLTELLQFKLKTYPPLRQTFVDSAVESTSTKSTDTTTGTAPDVREEFLIPSDVVIIRPLSMAVTQAVQSVSSCDSDSSEISSAIRGLNDLILRSDILWHWGSTAVLGLTPNLALKLGNHIDVNYLAMVEEIKHQTLRIPIPEIHGVLQQSGTRWKFIFMSRVPGVPLDSIWKTLNPHQKASVQDQLNVMFTDLRSLPFSPSDEPGAVYGGGTPRRCKDTRREIRVADAPISNEREFNCFLSFNPRRTGTGHHAMLRAYMATDHRLVMTHADLHPRNIMATLTPCSPGTNEVDGLCLQASTALAGTDDLPSGQVTITGIIDWEMCGWYPEYWEYLKALNTPFGGGEFDDWWKYLPPIIGTWPREHAVDLMLDGWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTM1</accession>
    <name>A0A370PTM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_117119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="102" mass="11493" checksum="48ACF8198AC00EDB" modified="2018-11-07" version="1">MSPCFRFDSSPFSYCRQVLLPFVIFITFYYFLLSCCLSLAMLFHRRGFGCYQSAGHQPFICNGGGRSVALSDTSSITCLLDRDPRAQLWQALVESFGGFSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTY4</accession>
    <name>A0A370PTY4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase, flavin-containing superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_333405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703474" evidence="1">
        <location>
            <begin position="23"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="466" mass="52065" checksum="55D919235B66C579" modified="2018-11-07" version="1">MHLIPPITKFLMTLNIITTTMSSTTSTTSATPVLTRDVCIIGGGAAGTYAAIRLQQLGKSVVVIDHKPRLGGQTTTYTNPAITPLPIEYGVTYYQNMSIVRDFFGHFNIPLTYSAFDYKIDMFDFVTGTAIPATAEAESNAAMDRYIAQLREYPYLRVGFELPDPVPEDLVMPFGEFVGKYNLEAGVGDLGGSIDPLGNWPDLPALYVMKYANLEVLEGDRNGFVRPKGRNNSELYGEAEKELGQEGLLLGSEVVSMDRDESADWVYVTVRKGEEETTIQAKSLVMAVQPSLDSLKGFDLGAKEKTLFGQFNNLFFYTALVRIKGLPDRMCYMNRGANDSFLIPRLPSMLVLKPTEASELKVANYLSTKALSEEEVKQGMLHDMESIRRRTEVDFPEPEFLAIGDHSPYQLTVPAEAIKNGFYRELNALQGERRTFYTAATWESHSTPQIWEFTEQMLQNHLLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU50</accession>
    <name>A0A370PU50_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_210056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU50"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="581" mass="66015" checksum="E599B656D8A22ADA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU77</accession>
    <name>A0A370PU77_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_122274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU77"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
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        <location>
            <begin position="54"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDK45747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="578" mass="62341" checksum="59D8E8AAD61AA891" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV66</accession>
    <name>A0A370PV66_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_332705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV66"/>
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    <dbReference type="GO" id="GO:0003871">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="186"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="408" mass="46437" checksum="EC7C81270BE166EA" modified="2018-11-07" version="1">MANQLHSAPPFRAEHMGSLLRPESLLAVREKIRDTGISEEAAGLHAVEKETVRDVVKLQQDLGYKAVTSGEFNRTRFWGQMWDEFEGTIRLQDAEASMFRLYHPDVVSLIEKDRKVMPGDSVIAGTKLSWNPEKSVSNLHELKLVQQALPESEWHTIKLTMITPAWFHMRYKQGKAYTPEAYANDEEYFQDVAKVYQAELDALYKAGLRNVQFDDPGMAYFCSKAFRQGWEEDKDNIGTVEDLLDAYIKLYNDSLSKIPADMHTGIHLCRGNFIGGRHFAEGSYDIIAKKLFENLNVNTFYLEYDTERAGGFEPLKFLPKNKNVVVGVISTKLRELEDKEAMKERIYKAADFVSAGSGETREEALKRICVSPQCGFSTHESGYPLSLEDEKKKLGLTRQIADEIWGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV81</accession>
    <name>A0A370PV81_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_309617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017011100" evidence="2">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="200" mass="21905" checksum="A156079FAB1D89FB" modified="2018-11-07" version="1">MKLSAVLSTLMVAGLVAAAPPAPRPTDVQPHHHPNPPPNPPLPRPHDNNKRDGPKPPKDEPKPDAPKPKKGPQPHHQPKPKPQSLEDGAHIRDPKSPQKRDDGPKPPKDGPKPDNAPKPKKVNSQPHDSSKPKPHKEGPAPKDPKPPHGDNHKRDGPKPPKDQPKHDNGPKPKPKPKPQPKPHDDKPHKDPKPQNQPRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVH4</accession>
    <name>A0A370PVH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_289730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="79" mass="7983" checksum="B1298C424D8A07CD" modified="2018-11-07" version="1">MSSSSVQVQPQPSGATKGVTSPTGSTPGSMNFDIVRCSRCQRSMSLENESSPGVCVVLCCAGAGAGAQATRRMAGAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVH5</accession>
    <name>A0A370PVH5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVH5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="63" mass="7568" checksum="0903807AB1C4B99D" modified="2018-11-07" version="1">MWMPVSELNLEDVNHERWRREGEDQSFMYVGRIPLRWNDDVNILVSECCRTTTCHDMRGGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVI6</accession>
    <name>A0A370PVI6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_332819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVI6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="89" mass="9651" checksum="CF625EE037254C11" modified="2018-11-07" version="1">MLGPIVGSAMLLVATAIFLYYTTWTLLMPFVDPGHPLHDLFPPRVWAIRIPVFLTLLGSAVVGTFIGIVMINSNKKKAAKAKAAAKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVQ1</accession>
    <name>A0A370PVQ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_100170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVQ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="581"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="842" mass="92455" checksum="95DB15C1E3F5C709" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVU5</accession>
    <name>A0A370PVU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_332904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15319" checksum="6DDE905B94DCAE17" modified="2018-11-07" version="1">MAICITFGTHEFTSMLEGYENVRAFCYNCQHWNGHCLTRWPWFTVCFIPVIPLATHKYKEVTCYTCRFTQDLRDRPDITPDTRPPPGVVPGQLPQAYYGGGAPFYPPQQASGPPPQASGGVVAPQQQAEQQNHVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW30</accession>
    <name>A0A370PW30_ASPPH</name>
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        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_281556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="11">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="1444"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1816"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1825"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1842"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1872"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1900"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1920"/>
            <end position="1948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="2031" mass="228249" checksum="304F2719150BC77A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW33</accession>
    <name>A0A370PW33_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_273500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="369" mass="40137" checksum="038B14E9DC595056" modified="2018-11-07" version="1">MANNRIVILGAGVSGLTTAYLLSQDASNSITVLAKHMPGDYDIEYTSPWAGANYLPYVLQGVGKAGSDHERWERNTWPALRELTKNHPEAGIHFQETIVYNRTKDQGSATGEWFSELVQKDPWYMEVVPDFQDIPADQLAPGIDNASKFTSVCINTAVYLPWLVGQCRKNGVVFKRAVLKHVADAANGHHTGQKADVVVNCTGLSSKKLGGVLDDKLYPARGQIVVVRNDPGKMVSISGTDDGEDEVVYMMTRAAGGGTVIGGSYQKNQWDPLPDPNLAVRIMKRAIALCPELVEKGQGIEGLDIIRHGVGLRPLREGGPRIEAEKVDGVSVVHNYGHGGFGYQASFGCAEDAVKLVQETLRRKDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW60</accession>
    <name>A0A370PW60_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_102679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW60"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="52" mass="5987" checksum="0A0BD2548B4C06B3" modified="2018-11-07" version="1">MYPCNWFGGECGVVQLEDCVGIWMGACSWYLYHLMNDSLGVEREVYDCRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWS2</accession>
    <name>A0A370PWS2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_273601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWS2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK46628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="478" mass="50925" checksum="86182B2FF2A3A587" modified="2018-11-07" version="1">MSAPSDPSASASSRGTRVHHRILAELGLISVWQSPRDVKLLCAQRFVRLFAYGGSTLILAAYLSALGISDERIGLFMTLTLVGDVAISFLLTLFADAMGRRAVLALGSALMVGSGILFASVGNYWVLLAAAVFGVISPSGNEIGPFRAVEESTLAHLAPNDILSDIFAWYSLIGNAGTALGMMTGGWAINLLQVIWGWPYIPACRVIFFAYAAIGALKFLLSIALSSAVEAEKKKPARQSTNEGERQPLLGDQTGNATPQEQQPQKKKSILSFLGDSEVVSLFLRLAILFGLDSFASGLASLSWMTYFFKRKFSLPEGSLGSIFFTTSLISAASVLVASSIAKRIGNVKTMVFTHLPSAICLALIPVPSILPLALTFLILRACSQTMDVAPRSAFLAAALPPDRRTAIMGSINVVKTCAQSLGPLLTGILADRGVFGLSFTIAGILKAVYDIGMLLSFAGKEKQQRRPAPRNEDEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWW1</accession>
    <name>A0A370PWW1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_305903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWW1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="843" mass="93739" checksum="DC018B1C5D69FCDE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX19</accession>
    <name>A0A370PX19_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_305968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX19"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016876390" evidence="1">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="380" mass="41867" checksum="1BA6DE8A117BFA93" modified="2018-11-07" version="1">MIASAVYTLLGLAPIVASSPTQLTLSSTTPYLDNAKSAVNTLQGWYNQTTGLWDTTGWWNSAICLTVLGDLTALDPSMLNSSSATFNNTFIQAPTSTLSHSVRKPTSQYKRQVPLNDTESSTEFLNDYYDDEGWWALAWIQAYDLTQDRRYLDTAVNIFDDMTGGWDTTCGGIWWDKDNTGNNAIENELFLSVAAHLGRRDTEKASYYRDWAMKEWDWFENSGLINSQNTINDGLDLTTCHNNNGTVWSYNQGVILGGLVELSQLVSNTSYLTTAHRIADAAMQALGDANGILKESCDPSCTGDAPQFKGILMRNLQMLYQVSPDDGLKQFLQQNANSIWQNDRGDEDQLGAVWSGPFTAADASTQSSACEALVAATVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX24</accession>
    <name>A0A370PX24_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter Nha1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_272554</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX24"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="792"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118758" checksum="227715DEC0F75D1E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXC0</accession>
    <name>A0A370PXC0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_306134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXC0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF160">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="503" mass="56176" checksum="88156426449F82CB" modified="2018-11-07" version="1">MVFAMALPSGQMPEINPSNLSLPVMAVVIVPWIFILLIKFLPKGPTIKGVPGSFLDLFCCGIATKFNFVTGRSAHYFNSLHASYAGKVVRFAPGQATTNTIKGLRNIYGAGSGKGSTFLKTGFYKGISRRNIFTASDPVYHASVRKLFNPSMTPNSMQAHANVVLECTSRLHDVINSTLKSTDTISLNRLLYCHSVDTVSEVLLGKSLGCLKRGKPYFWTEQLSRIFFWATIRDQFAGSGVPTMIKMMLRYLIRKGVRSRAEQARMRLINEQLTASHNRRDIMVEVMERAATSDLPVDEIAENFSAIMLAGFHTTQNALCATIYFVLTHPEAHAKLISELQAAFASPEDVSGDVAANLPYLNAIITESLRLYPPVPLGGPRVSPGAYVDGTYIPAGTEICTSLFALHHNPEYFNEPYEFIPERWTDPESTDKKEAVQPFLVGSRSCVAKYFAKQMMQLTLASFFLEYEAEYIGPVKDWQRESRCYAFWEVPDLKLKLRKREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY84</accession>
    <name>A0A370PY84_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Telomere length regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_323567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="135"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1580"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1590"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1619"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1682"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1765" mass="194897" checksum="124F5D425B89FCAA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ47</accession>
    <name>A0A370PZ47_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_287952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="162" mass="18723" checksum="189D3C83021D525C" modified="2018-11-07" version="1">MCRLVESLRLIPKEDRKKIHEYLFREGVLVAKKDFNLPKHGDIDTKNLYVIKACQSLTSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEVVPATHIKQQRSHAPPRGMMGGEERERRPRAPREGGYRRREQDKEGAAPGEFAPSFRGGFGRGRGAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ83</accession>
    <name>A0A370PZ83_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_271821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ83"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="228" mass="25679" checksum="A7A5EF76A7BE3DDF" modified="2018-11-07" version="1">MRPANLLRALQPLRSSMMRSTTTTTSSTTAPSLYQTTRRSLTTTVPRLNEQQQQQPQQEADLSSSSTTTTTTVVPPSLRSYPYKTKTGTVVSVGRMDRTVRVSHRHTIWDAHIQKPYPKITTYLVSDPRNSLREGDVIEFSSGYPKSRNVRHVVERIIAPFGSAIEDRPAVMTREERDAERAAKRAAKWERREARRVEAGVPEGEGKVGEHVGRIRRLVLERTGGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZF9</accession>
    <name>A0A370PZF9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_299474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZF9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="31098" checksum="F2687D946BD7E2DE" modified="2018-11-07" version="1">MPRGPTRRHPASARQSNFLITRHSERILWCIRATMETECSRLADTIHQLAQNHHKPRYLVAIGGSPGSGKTTTAKMVTHLLNKGSVKRTVLISMDGFHLSRAALDKLPDPEMAHARRGAPWTFDLPRFQDFVRRLYTWANAVPLCTSVKGWSDAEVLTAPTFDHEVKDPVEDGIIITPDTSIIILEGNYLLLNEPGWRDISSLFDYRVFINIDLQEARSRVAKRHVHAGIERTLEEGLRRVDSNDYLNALLIHEKLLVPDMFVESIPWSFTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q071</accession>
    <name>A0A370Q071_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_299715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q071"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="39716" checksum="884947FFA252C98C" modified="2018-11-07" version="1">MGKPFKSIYASSFGKFDGNSDKIPQWIRANGGQYSKDISKEITHLITTKEAFKDNAEAVRKAKQLRTIKIVSYDWLEDSLLSKNRRPKRETEYLLVNILKSENKKRGKERDKIRKKEKEKPRRKGNLKNQDPFGRKRKGVKAGTAVYQDARVTYNATLVRSMQGKNYKERYVVRVYESNKEPHVYATHLEYSRIGKQQSQLLTPLKADHDSAVKAFKEIFKDKTGKEWEERLNGVLPSGKRDADGKLLLPHENWFYYEHRAGMLSNFLRGVIDTPDGDDSMVVKQEHLDAPMQGIKHESPQDANDERPGSDKSIIVYDLTGSDVEILNCPRDKYTRSASPNCFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q086</accession>
    <name>A0A370Q086_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_244036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q086"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="562" mass="62045" checksum="BB48751B33D47663" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0E8</accession>
    <name>A0A370Q0E8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_331665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0E8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="522" mass="56166" checksum="A4FDD40413BB1FFB" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0Z8</accession>
    <name>A0A370Q0Z8_ASPPH</name>
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        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_272314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0Z8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
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        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK48122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="292" mass="32364" checksum="F65B77AD2006C818" modified="2018-11-07" version="1">MSKYGVLVMGPAGAGKTTFCSSIIQHLQNTRRSCFYVNLDPAAETFNYEPDLDIRELITLEDVMEELGLGPNGGLIYCFEFLLQNLEFLSEALDPLSEEYLIIFDMPGQIELYTHIPLLPSLVQFLSRQGPLNISLCAAYLLESTFVVDKAKFFAGTLSAMSAMLMLEMPHVNILSKMDQVKDMVSRKELKQFTNVDVNNLLGTAGDEETSSVATGDPSSKDTMLSGGSFQQLNRAVGQLIDDFSMVSFLKLDVQDEDSVAAVLSHIDDAIQYHEAQEPREPSDAQDVDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1X5</accession>
    <name>A0A370Q1X5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_261440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1X5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="868" mass="94498" checksum="4EC93C4FB205C907" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3R8</accession>
    <name>A0A370P3R8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_299168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000066">
        <property type="entry name" value="Rho GTPase activator (Bem3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="843"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="963"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK36516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1467" mass="159925" checksum="CB4A6538F5E327AD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4C9</accession>
    <name>A0A370P4C9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_243200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4C9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="485" mass="55493" checksum="DEA7172C37ECED22" modified="2018-11-07" version="1">MTADRTSEEVSAKDCRVCRTRRISCDRTLPHCRKCFSRNLRCPGYGINLRWGQGVASRGKLTGQAIPVRKDPQISQKALYRRAGVAVPDVDLQLLARWPSSPFDSLTTQLLDHFDRGVATRLAWVDDLHNPWRSLVLPLSHDSSTVRYSVLALASKDLAAKYPTDHHWAQRLEAISRHHQNVALSWLSRDMRDILQDPTAVQTRDQARHILASALILYNVELLTAPAAQWRIHIQCAREIVQWNIQSARSALYTNVADVFLFYEYYYTSVYIGLTTFDPVDQLQDDFPTHDNVTVFSDFIRIMHSVTRAERQTYTMQSISQPVPIESTLLDIEFAKARMMQMSHTIKFKTVQARHDFECLVHMFYHATLIYTHRVFSDSVSPDEYIQASLGVLLEHALPLSCSAAVAQDLVWPLFITGTESRGNPQMQNIVEEAMMNVIRLSGSLDRSRVLSFLKTFWSLELEPGTTWIQYARAKCIDFSFLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4W9</accession>
    <name>A0A370P4W9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_280078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4W9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016563079" description="Integral membrane protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="184"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59744" checksum="88A2F6C2A46E5028" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Q3</accession>
    <name>A0A370P5Q3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_279737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK37205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="29024" checksum="A729856873ED2638" modified="2018-11-07" version="1">MPRGPKKHQKRLSAPSHWLLDKMSGTYAPKASPGPHKLRDCLPLIVFIRNRLKYALNGRETKAIMMQRLIKVDGKVRTDPTYPAGFMDVIGIEKTGENFRLIYDTKGRFTVHRIQAEEAEYKLCKVKRVQLGKGGIPFLVTHDARTIRYPDPAIKVNDTVKIDIATGKIADFVKFDTGVVAMATGGRNMGRVGVVTHRERHDGGFNIVHIKDAIDNTFATRESNVFVIGQDKPWISLPKGKGVKLSIAEERDRRRALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5S9</accession>
    <name>A0A370P5S9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate-forming enzyme AfeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_321858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5S9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="441"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="549" mass="60563" checksum="CE17D262BA99E2E9" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5U0</accession>
    <name>A0A370P5U0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_93163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5U0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="408" mass="45772" checksum="5980B9F86FE319F4" modified="2018-11-07" version="1">MVYIRQHQLPKLREYRYAGVDLSLVSRYVLKPFYNNFVIKFFPMSMAPNAITLTGFFFVVVNFFTILWYNPTLDQDCPPWVYASCAIGLFLYQTFDGVDGIQARRTKQSGPLGELFDHSVDACNTALGVLIFAAAMNLGQSWATVLTLFGSTMTFYVQTWDEYYTQVLTLGIISGPVEGVLTLCVVFGFTAYMGGGSFWHRSMLETVGVPKFAFIPEHIYDMAFTQWYLVYGGVLLFFAIASSIVHVMQVRRERGQDPIKPLYGLLPLVAVWTLVPAYLYLQPTILENYMVPFCLYVGMINAYAVGRMICAHLVKASFPYFNMLLIPLALAVLDSAGAVLGYWPSVLGDGVRQIAFVWVCLGLSIGVYGSFVHDIITTICDYIDIWCLTIKHPHVEVVTANGDAKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P630</accession>
    <name>A0A370P630_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_224554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P630"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="460" mass="50052" checksum="E5D074A444457C51" modified="2018-11-07" version="1">MEDVMDNQILKAGDSFSLSPATSRLAGPLTRHRWGYEVDRDTSSEPYCPPATIFPVMVKRAGGGPKVSTLDTTEPNLMFGSGTTEPSPAHTPAGGEGVREWEGSLPHLAVWIDSEWILLVSHGRTSTQAEMPTSRPKGLNLDFPPDYGGFDAVLFFTVPISLIPFRLPDPVGQGWAPVSPPFQDSKAIVLSGNNHPNTGKASDTQTVVIAGHQHTLPQNICMQRSHQGVDFDKNDFSCLSYWHKVLSDSRRTTLGVTLMAMGPAMPNADATVLAIPGGRAISCAVLLTRSYAMVHMPFGQVANARTGLSKSKELLLPPYKIGLSRWQEHDCHKVFRFRFHTWVKSAESAAYGIGTEAPSSAETDPSFLSASERLFALTPRFGLGVLSSGTSWQYVMELGPCSRSTVRLIGSRKPFRMSHFVSDIHHFCGDPFGDGEESDLDRTSKIACVMGGNEEVGCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6J5</accession>
    <name>A0A370P6J5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_270587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6J5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="311" mass="34672" checksum="933F8B54D38E3BD1" modified="2018-11-07" version="1">MDASQLPVAGTSDVANQAHLEQSQSLDTPAPASLGLAGPDEFTSTNGYSSDSRAHYSSHEFNSPARDFHNENDQPRQNFSPLTHQPQPLSSSRPSSEMSTSLPQPTHDVSQKQPSQSTKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLIGTKYDHFVNFPREDQEEISIQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLAKAFDLKCTIPEIENVGEPLLLYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6M4</accession>
    <name>A0A370P6M4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_298101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6M4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="267" mass="30532" checksum="3951FBBDDD8A6204" modified="2018-11-07" version="1">MSEILAPEFEKRRKANFSESNKPNTMLQWVWDDSTEKDRTDEHQSMIQILATVPSTYTVAFAATQALFDLAARPEYIPIIREEFESVCDSCEEKRLTKEAFGKMTKLDSFLKESQRITPLALVSFERKTLENIDLADGTHIPKGSHIAAPSYHIGLDESHFSSPETFDGLRFHNLQQAEFERTGKPSTKHQYVTVNESSLHFGYGLQACPGRWFAAIVLKLLLGLMVTEFDVKLMDKGEGRPKSEIDRFFIYPDSTKMVVLRKREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Q4</accession>
    <name>A0A370P6Q4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_224032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Q4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="401" mass="44405" checksum="1706B49B7DB4EB68" modified="2018-11-07" version="1">MAAFVRVSGPPNGHFLIGYPGISATMPRIEGKVEIRPSVGITAPVNVSLVTISLHRRETIHPSADSVTKKHLAPPRKEITDIVGKEMLLFRCPAGREYEEVISMDLPFVLFIPFGRGGPDASRRVPPASLQLPSRTAETFYEIVVMVQQGHSDQRKYTFPVPISRYDTLSTFGMYNRPESAERVSDHLVTLGISLPRWSYGPLDPVSVYVKLSPNLDWIGKARKVTINKITIGIDEEIIYNHEGDEPQRKVRTLTKRTEPIGVKLPPSGFLTNLGLVFPAKDLRDSKGILPRSDMAFPAYAVTGFTTTASLYKIEYYLTVKAHLTSARDIVIRQPIVVCPLDHAGCKEEMDAIEQAAREAVHINPDNPMLPLPSIVRPSDPNALRHLGVAIVGNQKKPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P758</accession>
    <name>A0A370P758_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_88973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P758"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="511" mass="58208" checksum="AB58239F09BF16D9" modified="2018-11-07" version="1">MGCRGLWNLHVNGRWYRCCHPRGCISEPDHPVTLKKIKQLCEHPGELNAWEEAPFPAPLHSNLDWVYTIHLDAGTWAITFWDEAEGGLLPKTVCLDLLTACQASSLSRTDLRQLPSHFPTWTPEIATDDGSVQPAAEPLRLTLGFPTPLNELQARLFIDFLFSWRYYIDDPMTWYYGSPVFKRFCIAILRLAAWDFELSYDTDVELPISFNSVPSWNCPKDNVYWFHGFLVALHDDLRSQAMITSAVWKAQQYVGHSTISGRGVRLIMMSPYHIAFAELSNGFVTSTRSIVLLSNSSAMQCSPGFRALGRILTSDCWKHWTTNRETWKYPMPAEITQHVLQKLEPRDAVALSQASFTAEECYYARISQFPGMTVRSFPLLIPCCGRRSGLEECGIMCSVCYSWQHGTCVELPDGSDSDTYVCVPCRSDGSHNRHTFGGLQRFSRHIRRQGCQVRLDDTAKLLQPRLLKPAHLRPELRFRRDISRVPPEGIDYTIRFNGCFSGLAYGLDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7C7</accession>
    <name>A0A370P7C7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_298193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7C7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480230" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK37597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="534" mass="57753" checksum="664A8C8FD12018B7" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8L8</accession>
    <name>A0A370P8L8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_76157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8L8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="278" mass="32667" checksum="5A51B312ADD4B352" modified="2018-11-07" version="1">MHNFSEEFLARPEYQVIKAFVQDPDVSPAEAVQRLLRVREVLHREGREPPTDIDGTHTWIAMVTVVDLVSLTPAAQQHKFIEFIDHLQRTKVIDPVSGEEPTAVDMKLWTELPYLGVYLRDMYFFKYEPEYAQQVDDDPRREYPPSELQEWENRNAFMAQLTAKADHLGHIIDASLYALWACRETFEECDPLVEEAVRISCIWYIYASQRMWENCQVRRTFGDADNPSPRQRFTMKKWYHWRNGLKAAQLQFPRASTQEMIQKALTEIEKAEHGSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8R2</accession>
    <name>A0A370P8R2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_76418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8R2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF39">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK38577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="565" mass="62956" checksum="00F0B8929D333F18" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8T9</accession>
    <name>A0A370P8T9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_321138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8T9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="151" mass="17027" checksum="30A21453D32C68FC" modified="2018-11-07" version="1" fragment="single">MAVYLDEEFNNKVLGMKVCLMHIISSIPWSTQIGFVESAESQPRLAMSVDDYPFRHSRPVEASELPDGYFHIIPCRLISPPLDSSIIDRAKDDWSRAVGKELPVSILNEKDFSSSPHVYPECPPSKRGLMLGFVTIATLWNDEMGTLRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8V9</accession>
    <name>A0A370P8V9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8V9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="235" mass="22191" checksum="E8F93DE85420205E" modified="2018-11-07" version="1">MDSYGQDNFGGGRRGGGDSFGGNDSGFGGNGSQFGGGGSGFGGNDSGFGGNGGGNNFGGGNSGYGGDNGRDNNNFGGNDSNFGGGGSGFGGNDSGFGGGGGGGDSNFGGNDSRHGGNDSGFGGNSSGNSGFGGNDSGFGGGRNNQDNFGGSGGGNDSFGGSSGGLGGLVNKAEGFLNNHGGNNNNQGGSNNGGQGGNTGGNFVDSMVDQKVDQYVPSGMDGAVNQGINQEVNKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P944</accession>
    <name>A0A370P944_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_321209</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P944"/>
    <dbReference type="SMR" id="A0A370P944"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016869390" description="pectin lyase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="379" mass="39854" checksum="FC398DC1C935F222" modified="2018-11-07" version="1">MHYKLLFAAAAASLASAVSAAGVVGAAEGFAHGVTGGGSASPVYPTTTDELVSYLGDNEPRVIILDRTFDFTGTEGTETTTGCAPWGTASQCQVAINLHSWCDNYQASAPKVSVTYDKAGILPITVNSNKSIVGQGTKGVIKGKGLRVVSGAKNVIIQNIAVTDINPKYVWGGDAITVDDSDLVWIDHVTTARIGRQHIVLGTSADNRVTISYSLIDGRSDYSATCNGHHYWGVYLDGSNDMVTLKGNYFYNLSGRMPKVQGNTLLHAVNNLFHNFDGHAFEIGTGGYVLAEGNVFQDVNTVVETPISGQLFSSPDANTNQQCASVFGRSCQLNAFGNSGSMSGSDTSIISKFAGKTIAAAHPPGNIAQWTMKNAGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P983</accession>
    <name>A0A370P983_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_222081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P983"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="93"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="594" mass="67698" checksum="55805F1C9EA70D8D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9E6</accession>
    <name>A0A370P9E6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_269397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9E6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK38808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27194" checksum="349AFB1E827EDE18" modified="2018-11-07" version="1">MPTEITVTPSEIDFLETLQESKNSVVFKVTFQGKPCVLKQQYHDRGPSEFDPPDREVNLFIAESTAYQRLKSKGFCNRGVIPDFYGTIRNIQPALWPGLSMFLGDKLPPNAILIEYIPNMQAIGLSKYSERRMAKFRRILDDIHEANVLHGDPMPRNMMVSVSGDEERVLWVDFDSAQTFPEDGSHPRQKVWVEGEDELVDYFIAALVRFNVLVGEDYRHGNLSRTVSYYYDYFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9R3</accession>
    <name>A0A370P9R3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_278782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9R3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.60:FF:000004">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="272" mass="29774" checksum="F51988F9C0102EAA" modified="2018-11-07" version="1">MASTIELASSFIEGAPPGELADVVADVKALTSDGPDIIPSLAPAFERYNETQLATVKLPGASQEVLISEYNKLEGNRYFDVESQTSFEVDHVTQEASAAQSYVLESQNADLIKSLLKSLSAHATEHYRTCSYGVYPIEDDTAVAIVLVANRYSPNNFWNGRFRAIYTLPVNSSSTTISGQIKVDVHYYEDGNVALNTTKPVNLSVQSVDASAIISRIAAAERDYQEELNRAFVSTAEGVFKGLRRQLPITRQKVEWEKVGGYRLGQDIAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9R6</accession>
    <name>A0A370P9R6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_221947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9R6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="179"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43170" checksum="F040BE4AFA46E212" modified="2018-11-07" version="1">MTKANVNGKPKVAFIGLGAMGRGMAIQLLSEGFPVSGFDVNPMSLETLLAMGGTAAPSPRECVHDASFFICMVANAPQIEHVLFTESVGAVFGLEKDATIILCSTVAPGFPQKILDQIHHRFCRPDINLVDCPVSGGTLRAAQGTLTIMSSGAQNALGLAHPVLQSFSQTLYTIDGGLGCASKVKLINQHLAGVHIAIAAEAMGLAATMGINTKQFYDIVLKSPAHSWMFENRVPHMLRNDWSPHSALSIFVKDLRIVTSEGLNEDFPLYIASAAERLYQFAAQAGYEKEDDSGLVRIFIPQNLSWISEATHRESHAADHERTSRMICLMLSIVHGVAAVEALSLGIKLGLSIKALNSIISNTAGASRSFAAVATAMMGQQIAPIRTLTQCRDILVSLFAIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Y9</accession>
    <name>A0A370P9Y9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_296559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Y9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="101" mass="11194" checksum="EF4AD59AF05ACC29" modified="2018-11-07" version="1">MSAAAPPAPPVNGDRPETGHSHGKSSLSSKSDPNQALRGEEAVYSVGSSGFSLRSMQHRDREGKIITEPDLSNPTRYRFERPLDTIRSFEAAIERRRREAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAK9</accession>
    <name>A0A370PAK9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_338555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAK9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="236"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="325" mass="34056" checksum="92979D2EB0D87B91" modified="2018-11-07" version="1">MTASPSAAESIPEEIRAPEPKPINQTIAQIRSLAAGAAGGVCAVVVGHPFDLVKVRLQTAEKGVYSGAIDVVKRTVAREGLARGLYAGVSAPLVGVTPMFAVSFWGYDVGKTLVGKMSEVRVENNTPQYTIGQISAAGFFSAIPMTLITAPFERVKVLLQIQGQNPPPPGQKPKYSGGLDVVRQLYQEGGIRSVFRGSAMTLARDGPGSAAYFAAYEYIKRTLTPKDAQGNVTGELSMPAVLAAGGAAGIAMWIPVFPVDTIKSRLQSAPGRPTIGGTIRTVYANGGFKAFFPGFGPALARAVPANAATFAGVELAHQFMTKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAL2</accession>
    <name>A0A370PAL2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ResIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_62067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAL2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="292"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK39199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="679" mass="76335" checksum="3641A5E3BFA80096" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAR6</accession>
    <name>A0A370PAR6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAR6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="34061" checksum="36B6ED29D6346D58" modified="2018-11-07" version="1">MLHSKHLCRQFHTAARRVPLAYELHRPPTSNSTTSHNSTSSTPILFLHGFLGSKRENRHVSRLLAKDLFRPVYALDMRNHGESGHHPKHDYMEMALDVKSFIERHQLRAPTIIGHSMGAKTALTLALESPTLIKDVVAIDNCPIRLPLESDFVRYLEGLARLRDERITDHLQADKILSQYEKSPAIRAWLISNLHKKPGTPFLQLRVPVETLSTAIRPLGEFPYRVGEESQAIRQFNGRVLFLRALQSNFIPESALPLINSFFPSSEIVDIDCGHWIVQEKTEEFRKIVGRFLLAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PB14</accession>
    <name>A0A370PB14_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_256152</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001751">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1569"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="855"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1569"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1843"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1429"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2059" mass="230406" checksum="2B166E162C3D6CEC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBF9</accession>
    <name>A0A370PBF9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_255235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBF9"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="304"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="563" mass="61729" checksum="CFCB758859635FF3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBS8</accession>
    <name>A0A370PBS8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_268682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBS8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="310" mass="32978" checksum="DD1833DC05A628E4" modified="2018-11-07" version="1">MASNLRLKALFEVKDRWVAITGAGEVPSKEKNWLNIDILLSGSGIGRILARGCTVNGANTILIDVNERSLEETKTELQELSRSEDLSPTSVVTIHGDLSSEAGVTAVVAAIKSIRGSLDALIHCAAVRYMNEVTYKPGGSLGDLEDATMSAPYQGWEQTFRLNVLAPYYLTAGLVRPLGTAAAKGDGRGCVLMLSSPASVHNHQFVPCYQTSKAAVDHLVRIMAAEFADYYIRVNGISPGIVPSGMTTTDANSNLHLAAEAPAGRAGNEDDMVGTMLWLISKAGAFMDGKVFRVEGGRLLILRGATCHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCB3</accession>
    <name>A0A370PCB3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_304200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26389" checksum="F271A92BEAE1B477" modified="2018-11-07" version="1">MLEQGAYSDVDACLMVHPMPIASGFLAIDEVRVTFIGKPAQAAAAPWEVHGIIVSGGDRANIIPMSAMEYSMRSPTSESLNVLKRKLTDCLEAAATATGCELELTWGVGYADLKPNPTICRSYVSALKAMAHHAVFDGSNIEGVLNGGSTDMGNVSHAVPGFHAMFAIPTEGVNHTPQFTAGAGSAEAFKRSLACAAGMAVTACQILVDDTFAAQVRSDFDSGWCLSRFDPFSLDSHAKLYDLEEYGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCL4</accession>
    <name>A0A370PCL4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_277846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCL4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9780" checksum="4E2B8BB1204F3149" modified="2018-11-07" version="1">MAPNPTGFDINEFKAAAHPRSAWAKKDPWARYEAWRYTGPFSRFNRFKRIFPGFGIASVAFAGYCAYEHFFLKDDHHHHGEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD34</accession>
    <name>A0A370PD34_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_277999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD34"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK40109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="103" mass="10870" checksum="0D71B77E1031EC94" modified="2018-11-07" version="1">MESLLAPIQDALEGQIDFQGQRIAELLSTVLLVLSGAVAFIVGYIFQDIHLTLWVGLAGTLITGLAVIPPWPMYNKNPEKWLVPLTAGVGGGAGIMVDGVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDH4</accession>
    <name>A0A370PDH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_337430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="158"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="406" mass="45482" checksum="0FF2726635C37051" modified="2018-11-07" version="1">MLINHFFESNGSFSYEALRAAGYSNYGGADLGEVIAICSKIRPGNEEDWVREWRNAAERAVSNADHSKTAKNSESAYHGYLRASNYFRTAEFYRRENVDEDEISQSLYESSESSFVKAMEVSEFCYEPISIPYEETSLPGYFVRFDRTGKPRRTIIFNGGFDSTASEGWFAIGAAALARGYNFLAFDGPGQGAAIRSQGMHFRHDWEKVLTPVVNYAISRPEINANGIVLFGWSMGGYLVARAATQEHRAAAIVLDDGVYDFGSAFRNAQPLLVQKLVERKYDAVPNLLFEFVSSFSTGTRWALRNGKWTFGVDSAAELSRATSKYTLEGISHDIVTPCLIIDAENDHFLKGQPELLRRNLSCACEFVSLGAEEGGDTHCHQGAFFRLHQVVFDFLESRLQPERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDM1</accession>
    <name>A0A370PDM1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_41346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDM1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK40303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="12344" checksum="15649CB63CFD965A" modified="2018-11-07" version="1">MVSPYFPWKCRPRTQLIRIRVGHSRLTYNLLLCTRKAVGPACHGWARSRRSNAAIGEWKRSCKERVRFHPPRSHSVRLCNPPMSSEECHLVVRTCLLLMPLAVHLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEC7</accession>
    <name>A0A370PEC7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_236495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="491"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="705"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="808"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1418" mass="161067" checksum="4F61C1D8F048C378" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEF8</accession>
    <name>A0A370PEF8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation diffusion facilitator family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_337101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="396" mass="42840" checksum="136300FF795161CE" modified="2018-11-07" version="1">MVLKISRATRLTVVVVISSAFFVAEISVGFYTHSIALVADAFHYLNDLVGFVVALVALKVAHDTVRNVATGTEIKLQVSEADESPKALSFGWQRAQLLGAFFNGVLLFALGISIFLQSIERFITLQRVENPKLMFIMGAIGLTLNLISATFLHEHHHHDHGHEPSSGALEELPVSTTDDITGSERPGSPNHNDHKHLSNGAHAASHGHDLGMLGVLIHVIGDAANNLGVMAAALVIWLAHYGGRYYADPGTSMGISIMIMLSSVPLVRRCGIILLESAPNGVDLEDVKHDLEKIPGVLSVHELHIWRLNQHKALASVHVMVSDCSVPSFLKLSKTINECFHAYGIHSTTIQPEMAHPEAIALGRPAVETELSSQTEMSEKCQVICGTLCEELTCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEU5</accession>
    <name>A0A370PEU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_267780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="259" mass="29168" checksum="E1D4C85CEEE51539" modified="2018-11-07" version="1">MPPKPAPYLPLLSSHLTSSPTSTSISLTTLSTHPITRTPQPRSRTVEFRGFFPTLNLHSSAVQSLKDQHIGLNPDIYESEMIALTTDKRMEKVQEMESSGGVVEAVFWLKEVGNQWRVRGRGVIIGGDPEDQGEKEGRGFIEKGLRRKEDGGNGAGDGEWSWERQVDMYFANHSPGMRGTFKNPPPGTLRSQDPGNPELKLGQKVEDLKDKVARENFRVVVIRPEEVERLDVNDPSNPIRTRWTAVRDGEEWEEVDLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PG33</accession>
    <name>A0A370PG33_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_294812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PG33"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK41148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="777" mass="85974" checksum="7E896159858D03F3" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH92</accession>
    <name>A0A370PH92_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_267063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH92"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="118" mass="13345" checksum="92076610BC2E5AC0" modified="2018-11-07" version="1">MPKHQEHSSAQPLGPHSTRTILMILCCGPLSMLRRSVLIRWDEFSQLSAIRAPQAQLSSAKRCLLTRLRGALKARKRLHNMRPSIMLKQLSGHADQTASSYTFRIATYIKSSPTFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHM4</accession>
    <name>A0A370PHM4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_302210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="492" mass="53779" checksum="9F8C1B63B845D6E4" modified="2018-11-07" version="1">MSSDQNESSTVDAVTEERPAPPYTIFDRSQKRLLAVLVSAAATFSTLASNIYFPAIPSISRSLNVSTELVNLSITSYLIFQGLAPSLWGPISDVKGRRIAYIGTLFVAVCACIGLAETRNYTMLIIFRCLQSTGSASTVAIGSGVIGDITTREDRGGFMGFFQGMMLISIAIGPVIGGALAGSIGWRTIFWFLTVYSGVLLTMIGLLLPETLRSIVGNGGQLPSPRIGRYPLTLYQRFSKTNWRETVGYSRLAPKKRTELLGPLRILISKQAAPLVLFFAIYFAVWQMTITAMATLFKEHYGLTEIQSGLTFIANGAGSMVGTLITGRILDKDYRRFKEQELAETSPSRQEKLFPLERARLRLVPIFAGLQCLSVMIFGWTVQYSSHVHIAVPIISTFITGWTAVSNQSIVTTYLVDVFHDSSAAASASLNMTRCCLAAAGSGFVMPMVNRVGCGVAFTVCVAAQIFANTGLWIQWRYGGLWRSEMEKKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHU5</accession>
    <name>A0A370PHU5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_293757</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHU5"/>
    <dbReference type="SMR" id="A0A370PHU5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK41768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="305" mass="33480" checksum="A09CB317DE80134E" modified="2018-11-07" version="1">MSAFSPENITGAFIPSALFVAGTFFFKQELTPFAVALAAVLVGWKVFSNKPRKVLNPGDFQHFTLKEKNDISHNVTVYRFALPRPTDILGLPIGQHISLAATIGGKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLEVGQTMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMYQIIKAIIRNRPRNGGNDTTQVDLIFANVNPDDILMKDELEQLAKEDDGFRIYYVLNNPPEGWTGGVGFVTPDMIKERLPAPSSDIKVLLCGPPPMVSAMKKATESLGYTKARPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHW5</accession>
    <name>A0A370PHW5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_336161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHW5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK41752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="38792" checksum="3EBDD10F152C54D4" modified="2018-11-07" version="1">MYEEMEYALDRELGNPHEWHPLPTFPTILRIIALVSGRINIGLPLSRDPTWLTLYTKYPLTMMESVSSLMKYPAILRPLAQHFTPSLRELDSIRNEITALLTPEYEAILSGKSDRNTMVRWLWENCEEHERTITYQSQVQAMMSIGTVLANAAAAAQCVVDLTEHEEMIPLLRGESEGVVGGNGKDEISKQALTSLSMMDSFMKESQRFKPPGAVTFERKVLEPFTLPDGTRLHAGEHIAAPAFHVGWDPEYIENPEVFDGLRFHRLRNQGGLSATTAAGKYHYVSVNETSLHFGYGRNACPGRWFTAIQIKLLLGRLLVRYDVTSGEGSDTVLIRRRKGGEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI47</accession>
    <name>A0A370PI47_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">M752DRAFT_20858</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI47"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="204"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="898"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="828"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="828"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1033"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="609"/>
            <end position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
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                <person name="Sandor L."/>
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    </evidence>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
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                <person name="Strasser K."/>
                <person name="McDonnell E."/>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="334" mass="36992" checksum="7DC29E320FF2F5E9" modified="2018-11-07" version="1">MTDSEITGFQSHHKDFTTITGQTPSLELLAEHRDYPFAHEAGIYIPETNNLWITSNRCVDPNGSKTQQRVYITRVDLNTSPITYEEIPTDIPMGNGGINYDKDSILICGQGSMTQPSGLYRMSITAPYTTELLKGDFFGRPFNSVNDVVVHTDGSIWLTDPIYGYRHEYRPEPCLPCQVYRWCPREGTIRAMADGFGMPNGICFSPDEKTVYITDTDRLHGDGTVFDHRASSIYAFDVSTIHGQPFLTNRRLFAMADHGIPDGIKCDLNGNVYSGCGDGIHVWSPGGVLLGRILIDGGVANFCFGRNGEIFALNEHRLWRVQLGAGVKGALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJV8</accession>
    <name>A0A370PJV8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_234466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJV8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="594" mass="67326" checksum="1353CB9FD39B1C16" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKG6</accession>
    <name>A0A370PKG6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_214587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKG6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="608" mass="69067" checksum="80C221A6C3B4F6DC" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKX4</accession>
    <name>A0A370PKX4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_335576</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="264" mass="29428" checksum="3BF32CD1810D33E6" modified="2018-11-07" version="1">MSGAVGREAVFPTRQSLGLMKGKLKGAETGHSLLKRKSEALTKRFREITRRIDEAKQKMGRVMQIAAFSLAEVSYAVGGDIGYQIQESAKQARFRVRAKQENVSGVLLPHFESYTEDGINDFGLTGLGKGGMQVQRCRETYARAVETLVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDELDREEFYRLKKVSGKKQRDNAAADAEILAARQQEASRLQESAAAEKKEEEAPEAPDVLGEQEDADVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL40</accession>
    <name>A0A370PL40_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_163689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL40"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="345" mass="37854" checksum="13D7B333BA5C9040" modified="2018-11-07" version="1">MPTVLLPSSAAAFAPRSSPNVVLNARIEPWLTATLKRVNRVKRPLNNVTQHTRCLTETLSSPDAIWTLCSLMFPKAPDAELKKDDNPLVEAMYNYQMVHVEAYVVHVDMVSQNEVAFKLTPETIEALVDYHKDIYSVDTAASTWDWPDKDSQLKKLHEEFVQAVNKFVYRTEALALEGLEEDGAGELLGGRSDDAKAAITSLFVPLLPPPPRVVDVLRSTPLLPSSTVPGTWWQEPMPQTLPLESWKVLPSSPATTSTGEPNAGMWTTMNGMGEAQLTSPTFSQPYTTSPYNATQYYSTAATSAAIAALPLPSMLVQPCSTAAGLAGFGWENRYQDFTLPYGTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLH3</accession>
    <name>A0A370PLH3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_161155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLH3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="424" mass="46894" checksum="9E61EFDDE021A286" modified="2018-11-07" version="1">MNPCSRGTEHPCLLAAHIMADLPVLIVGAGISGLLLAQHLQKLGVPYKIFERDAAIDARSGGWGLTLHWALPALRELLPDHLVQRLPEAYVNKAAAARGDTGRFSFFDLKTGSALYSVPAAERIRVSRVRLRQLVATGLDVQWNKTLQNIESTADTVTAHFADGTSYTGCLLIGCDGSRSPTREILYPDSHEMNPLPVQILGAATLYTAEEMAGAAEIDPFIFQGSHPESNVFLFFSILDTPNNFVESSKDKYECQIILSWADSKDIAVPSDNGERIALMKSLASDWAEPFRTLVHRLSEDTEARSIRIADWMFRPLQNRSHPRVVLMGDSAHTMTMYRGEGANNAIVDVLDLTQRVDMRSLGTMSTQALRDALDAYENDVFRRAEPSVLNSRQACVDAHDFTRILDESPLVSARVLKEDTTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLM7</accession>
    <name>A0A370PLM7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10353" checksum="9F1974B50F5F154B" modified="2018-11-07" version="1">MSESTAEAVPPPPTTSTQNSDAQGQFSAAVDDLLDQLQHKFDGVSREMFGKLDDMARRLDELEASFTVVDGTTTSGGGGGASASQTGTGSVVGSAAGSGSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM01</accession>
    <name>A0A370PM01_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_275472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41487" checksum="F5BBD088250A0A56" modified="2018-11-07" version="1">MNTTHRRRQAFYALPSAHWQMLAEPPFSILDNFNRVDDAIDVNADIADAILTTGLSSFGLSANPDPSDPRQNWHGTATQSDVNKAHSTLRQFYRDWSHEGQAERDVCYGPVLSDLQDEFGARIGSSEDEDEVRVLVPGAGLGRLVFEICRQGFAAEGNEISYHQLLASSWILNHTLGPQKHALHPFALHFSNLLSREQQLQEVKIPDQHPGTAMVEAQANSAPFGRMSMSAADFTVLYTNPSNKEVFDAVATVFFIDTAPNLIRYIEAIRHCLKPNGVWINVGPLLWHFEDGSNRSQHGGSDEGHGDQGIGEPGNVELTEAEVFCLVERMGFAIEKREAPDRRPMCGYIQDPDSMLQPLYRPSHWVARKQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PM61</accession>
    <name>A0A370PM61_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_201267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PM61"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17154" checksum="80BE67A4B4B07EE6" modified="2018-11-07" version="1" fragment="single">MDAQAYLLRHGWSGPGNPLNPNRRPGTHGGLGLTRPILVARRQGNQGVGKKTTKDPTNQWWLRGFEDALKGVGDENKSAGDAKRTPNALTSELYRYFVRGETVPGTLGNKDKKEDGESRKRKAGEDDEDADGKKKRKKGEETKEERRVRREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMC3</accession>
    <name>A0A370PMC3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_335163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMC3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="103"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK43339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="451" mass="47730" checksum="35B0E233FF9C6367" modified="2018-11-07" version="1">MSYRNLSSLDVSDRANLPDYELHNVPVAPPYTATASAPAAAGAGAGAAEATQKAGVAKGAGGPWYDPRSWSLLTKLLVAGGVVVVIVALVVGIYEGTKSSSYPDYSALSYKLADTYSGSSFFDEFEYYTAADTTDGFVDYVDSSTASEMNLTYASSSRAVLRVDTDTSNQTSGRKSVRITSKKTYNNGLFIFDITHTPYGCATWPALWLTDPSNWPEHGEIDVLESNNKATHGNAMTLHTSSGCKMNVKRKETGTAKYTNCLNTANDNAGCSVTGAKATYGEKFNSNGGGIYAMELRPAGIRVWMFTRDSIPSDISNSSGTPDPSTWGEALADFPNTNCDISSHFKNQSIIVNIDICGDLAGASTYYTDLYDCPSTCTKWAAENGGNFTNAYWEFKSFKVYQTSSTSNSSSSASATASSSSTAVGYGASAASTTTTAADGAGTQKILTVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PN26</accession>
    <name>A0A370PN26_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_275780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PN26"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44595" checksum="70DACB1DE801B193" modified="2018-11-07" version="1">MPTFKRKARKPRACVKTGGLWNDEERQRLWDQRSLYRHMHWKPFGKIFFPHRSLNALQKAYSNMSIQRRLTANMSNPDTPQDPPAGRIVTLRTRANKRSLPDESAPESRPGKQTRTAAVLSSGKDQVEETDQNGMTDEDSSSDYEQDSDEETLQGPSLPFEEEESQDGIETIVIDDGNNDPESHQNGEEEAEVHRPDAEENTDEPVSRSTTGVSSNNPPPTRLMPGRKSMTPSSRSEEKYAGYEKLAKEATEPTRPSLPPDVQYLKNLTWRFETVFFKTHDQEKVISSLQSQVEDLKNLNSDKAAKLESAQEEVRKQLQTIRSLEQREQKYKKEIDDWKRKIKVSEQQVTVLECKVAMARNQNKCETCERVSKFFAPASASGKAGESSGSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNB7</accession>
    <name>A0A370PNB7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_291858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNB7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="208" mass="22475" checksum="685FCF5085121D2F" modified="2018-11-07" version="1">MRGSPSSGSKPEKTMSSRLLTMKFMQRAAATNAARETSQPASTDDSKVSTPPKRQRLSTGPAESPVGTPKSDLEAISAALAEEEEKRKEALARQAQDSGDTEWVLDYGVAEPVAQYAPPPFIVADGSLDADDDDIAVGGRQAYGNFKRKKKTATGETEAESDDDDVDAMIKKESNKPHRVKLSQLTSISGGRHATMGDDKKQKKRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PP45</accession>
    <name>A0A370PP45_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_212471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PP45"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="402" mass="45430" checksum="E03587681C2B7475" modified="2018-11-07" version="1">MAPQLHRNPPFRAEHLGSLLRTEELLKTKTAFEKGEVSEAQLDAIENKDVKEVAETQKKLGYAAISDGEYRRHMFWGSFFPGLEGFEEVRDVDADVFRPYAPDVAAFLEAGHKPGETVICTGKIKHVGSTYTKEFKYLASVVPPEEVKNLKITLAAPNWYHLRYKEGKAYPKDVYSSDEEYFGDIAKAVQAELQELYDVGCRNVQFDDPNLAYFCSEKMLAGWKEDSLNVRSADETFEQYIKLYNDSISKRPADMHIGVHLCRGNFVGSRHFSEGGYDRIATKLFKELNVDTYYLEYDTPRAGGFEPLKELPTHKNVILGVVTSKFAALEDKEEMKKRVYDAAKFIAEGNNISLEQALNQVGVSPQCGFASHREGNAIDRDGMIAKLKLVREIANDIWPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPB7</accession>
    <name>A0A370PPB7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_334878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPB7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="180"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="435" mass="49341" checksum="125FDD32B616391B" modified="2018-11-07" version="1">MFARPRLCTLSSRPSAVKFLRQPRSQYLHATPPLSYPRRKDFFSSNAYLYQKQMKNGDTTDETVLESQKQRRRSNRSPAASTSLRRVAVEAQRSKDGMLSKAQLREQGLYQPKTVTAYAVAEQFNIRKVRDILQERGYEPDPYETGLYPQVVHIEVPLDSIRRQSNPNTLDLSPSEVGDVFVFPSGTVVAWALPEGFTSFLATRTLLPAAEGAHLDDLETEDLEYVEDSQRENSSIKGDTIILGTKPGNDGPNSHLPTRQSVDTVLTKVAFSSGLARSTKLAVLESLLANYFESTRPIPTLLSKGSRLPFTRDFILRKTGQLLSVRAQLNLYSELTDSLPDIFWDSRHELGLEGYYEQVGRALDVGIRIKLLNEKMDYAQEIASVLRERLSETHGLRLEWIIILLIAVEVGFEVLRLWKERVHEQEAKKEQATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPE7</accession>
    <name>A0A370PPE7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_325940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPE7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000006">
        <property type="entry name" value="CFIA complex component Rna14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="10">
        <location>
            <begin position="253"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114155" checksum="8D22EA1D77EC15E0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPN2</accession>
    <name>A0A370PPN2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_152679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPN2"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="421" mass="47193" checksum="7601EF654CEC31C4" modified="2018-11-07" version="1">MAATGAPQRWKHLYSVLTKSGPFSDEDWVPGQETISALESSKILVIGAGGLGCEILKNLALSGFKDIHVIDMDTIDISNLNRQFLFRQSDIGKPKAEVAAAFVERRVKGVKITPYVGKIQDKDEDYYMQFKIIVCGLDSIEARRWINSTLVGMVDFEDPESLKPLIDGGTEGFKGQARVILPTLSSCIECQLDMHAPRPAVPLCTIATIPRQPQHCIEWAHQIAWQEQRKDDAFDSDDMEHIGWVYNAALERAKQFNIPGVTFQMTQGVVKNIIPAIASTNAVIAAATTSEALKIATSCNPYLENYMMYAGEEGVYTYTFEAEKKPDCPVCGNLARKLTVNPNMTLEEFIETLGERPEAQLKKPSMRTEEKTLYQRFPPQLEEQTRANLKLKLKDLIEDGQEIAVSDTAYIIDFRFRLAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPS3</accession>
    <name>A0A370PPS3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_334123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPS3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="206" mass="23453" checksum="81328A85B4C39C3B" modified="2018-11-07" version="1">MALHPKFLGQKLLANAQQPWHTLELYLDYVCPYSAKLFNTFYTSVRPIILQKYQSRLQVVFRQHIQPWHPSSTLTHEAGAAVLKIAPDKFWEFSAALFNHQEEFFDVSVVKETRNKTYQRLAKIAATVGVDEHEMLELLNISEVMPDGQLNTGNKVTNDIKLMVKSGRTIGVHVSPTVYFNGVEEPGISSSFTATQWEQWLAMNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ22</accession>
    <name>A0A370PQ22_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_137890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ22"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="29074" checksum="3B403B4A5DC18F6C" modified="2018-11-07" version="1">MSKTPLYTFCLISLTLTTLFLTTITILLLTPPTFLPRIIPPMCPSQSQSLSRDQTHGRVFNERPELERTVNDSDEVQTWESILLPPGGGGIRSHTIPDSIHLTADEKKEEKVLSWGISMFHQLHCLIVLRAIVFPETTENTINSTSQAHSGDMLHDKVHWAHCFDYIAQGILCAADDTIERPRKTQVRHGKTIFDVDGVGAVHQCRDAKVLWQASVKSLEEPVDMENWREGVGVRAFLGERKMGQDEEVPELYTLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ28</accession>
    <name>A0A370PQ28_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_291431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ28"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484261" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="508" mass="55041" checksum="43F6D9CF4193D229" modified="2018-11-07" version="1">MGLKAFGFIVAAAQLSAATAAVSRLTVDTTVGRLYGMVNGSAPDVAQFLGVPFAAPPVNELRFAPPQAKPAEAIIDATKIGPSCPQYPLTTKTDPSVYTFDSPWLQPYGPTSENCLTLNVWSPLHAVNDTDEPLPVLIWMFGGGFYEGGLLTNGFDPSNWIQRTQSHIVVAINYRVNIFGFPNAAGLAEIQQNLNLGLLDQRFAVEWVRDNIAAFGGDASKITLWGQSSGAASTDYYNYAWPDDPIVSGLIMHSGSVFATGSSADVEHTNFTFVAEHMGCGDLSPRAELACMRNVSADSIIQFYENYTLYSTGPTLKFTTIVDNVTKFEDYTARAYAGNYSKLPAIFGTNANEEASLVAWAGPQGPNMTYVHEETVSTHLCPANYNGHLRYNTSSLSFRYFNTANFSNISPRPWEGAYHSSELPLLFGTYSEYGGPATPFETAVASHWQDLYLAFMRDPVNALPAMGWPAYHPDGYAMMFAANGTVTSLLPMSTLETPCAGIPEPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ81</accession>
    <name>A0A370PQ81_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_274703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ81"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF2">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G05520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="483" mass="51044" checksum="86C0DDFE31F1339B" modified="2018-11-07" version="1">MTAPPRPPVIPLIINGQEECTGSTFDVISPYTNQTCWTTASASAQDAIRAVEAAEAAFPSWSQTKPTVRRDILLKAADILESRLEQNAEYMRTEMGADVGASQHFIVPLGIRMLRDIAGRITSICGSVPVVEEEGQSAMIYKEPMGVILGIVPWNAPYVFGVRSAACALAAGNTTILKSSELSPCSYWALARAFHDAGLPAGCLNLVSCRPQDAPEVVNAMIEHPAVRKINFTGSTAVGRKIAGACGQNLKPCLMELGGKNSAIVCADADIKTAVKGVVGGAYLNSGQICMATDRILVHSSIAPVFIEALKEALTSGVDPASQPPTLVNMASKARVNKLVKDALAGGAHLIHGSVDQESAQSDNGVRMAPVLLGGVNEKMNAWQEEAFASLAACMIVENDEEAIKIANSSGYGLSAAVFTEDLRKGLAMARKIQSGAVHINSMTIHDEAVLPHGGVKNSGWGRFNASQGLEEFLVTKSVTWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ97</accession>
    <name>A0A370PQ97_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_274735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ97"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="458" mass="49522" checksum="CB6276D04E93FF17" modified="2018-11-07" version="1">MAPSHEAAINTQTNDADILDKEDQRSQNTLQESELAADTEKQAPSQPPAQSPWGTADPPPDGGFAAWSVVLGAWCAYFCTFGWINSIGTFQTYYETTLLSKYSTSTIAWIPSLEVFFMFFMGPIVGTLSDRLGARVVIIAGSFLHVFGLMMTSISTEYYQVLLSQGVCSAMGLCAIFQPSMSSIPSWFNKKRGAAYGIIASGSSAGGVIFPIMVDRLITRVGFGWAMRIAAFLILGLLVVTCLTVRARIPPMKQRMDKEALMRPYKEVKMLFLVSGFVLLTFGVFIPINYMETSAIADGMSTNLAQYLVPILNAGSLFGRMGAGAFSDKVGPYNIFVVVCSLTGILVLALWIPATNNPGNIVFAVLFGITSGAYFSLSAALVAKIAPLREMGYWTGVLFLFASIGALTTNPIAGAILQRDDGSYTGMKIYSGIFLLAGTVCVLMTRIRQTGWVLKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQI1</accession>
    <name>A0A370PQI1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_139893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A370PQI1"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="RDK44452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="404" mass="45075" checksum="52E9D69A02E4F884" modified="2018-11-07" version="1">MGSGELRVGPNRLFQLESVNVEDFKKICSQTTDPASYPLAVAVQKNIPIYDAATFDPLNADTTAALQAEWHHVLESGPGIFVLKGMYHPSRYADTLNATNTAFQHIIDRERQSLGPKGDHFAASGKNDRIWNSFSKHAFVDPSSFITYYSNPWLRAVSEAWLGPAYRVTAQVNIVKPGGAAQDSHRDYHLGFQELDRCAAFPRSVQLASQYLTLQGAVAHSEMPVESGPTRFLPFSQTYAPGYLTWRRDDFRAFFQANYVALPLEFGDGLFFNPAVFHAAGANEMAESTGFHRKANLLQIGCALGKTMEHIDAVPVVEKCWEEVSEMYRRQGGLSAELEAWVYAVADGYPFPSNLDRRPPAPSGMAPESEQEMIVRGLQEAWDRTRIVEELRGLQREGRGHQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQT1</accession>
    <name>A0A370PQT1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_141214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQT1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="577" mass="63419" checksum="817E1B65F8CE038A" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQW4</accession>
    <name>A0A370PQW4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_274881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="205"/>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="44637" checksum="7CCEA96FF2747361" modified="2018-11-07" version="1">MSTRDSYSHSRSHRDRTHSHTRSRTRSRSPNRDPTSRSDKHRSSRHHHHHRHHHHRHDRHRDHDRDRHRRDRHTSRSKDQPEPAPAAPIVLPFNSRELTKYDLEHYAPMFDMYLDIQKGIIMDDLAEDEVKGRWKSFMRKWNRGELAEGWYDPATLEKARTNLAQMQAQTSTNTGYRGESQQDERRDATRDRDVEGEDDEDDDEYGPVLPSTSGRGGGPSSGPTIPTMQDLELRKELAAEDAIAARQDSRAQYRSELRSHKSEIKYLQEEVAPRAEPGTHERRMEKRQEAAASNRAFAEAKRGGSPEAAPEEELMGSGENDLDSLKKAREREQRKKNEREIRREELLRARAAEREERLQQYRQKEEETIGWLKTLAKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PR10</accession>
    <name>A0A370PR10_ASPPH</name>
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        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M752DRAFT_282604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PR10"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="144"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="654" mass="74819" checksum="5388EA88CB8EF2D4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRA9</accession>
    <name>A0A370PRA9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_291586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRA9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="55"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="471" mass="50487" checksum="E7F97F446ADE86CB" modified="2018-11-07" version="1">MESSIGNLEAGNGSNKFNKEPLPAKLNAWVDGKLPDAVDDGEQQIIEAGEAKYHRLGWKGLTVMLIVEAIGLGSLSIPSAFASLGMVAGVICCVGIGLIAIYTSYVIGQVKLAFPAVRDYGDAGALLMGTWGRELFTFMLILQLIFLTGSNCLTGTIALRHITSSGICSVVWSVVSAVILLLLSIPSSFADMAWLGYVDFISIVAAIGITIIATGIRGTDSTGGLAAVDWSATPQGDPTFSDGFIAISNIVFAYTFASCLFSFMDEMHTPKEFTKSIWSLGILQIVIYTVTGATIYAFVGADVQSPALLSAGTLVSKVAFGIALPVIFISGAICTIVAGRLIHGRIYANSVTKYINTPKGWITWLTVITILTIISWVIAEAIPFFDDLLSITSALFTSGFSFYLPPIMWYVLIRKGPWYSKENLLTSLVNLFVFIFGLVVLVGGLYSSIQDIRLNYREGDVNSPFTCGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRG0</accession>
    <name>A0A370PRG0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_333679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRG0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="439" mass="47892" checksum="4B18EEC6CD221D8A" modified="2018-11-07" version="1">MYALPVGIVFLCLATVTVALRLYTRLKLVRKPGWDDLLIVLSLATDVVFFAFLVIEIQNGLAENEADLAPEVVRRQLKALWITIPLYNLTLTLTKLSLVFLYRRLFPTHTYRILLILTLIFVIITGLWMVLSTLIFCIPINAFWDTSIPHTCLPEDVVWCLNAAFQITTDLILVVLPLPILANLNLPKRQKAALLVIFALGFFVCATSIVRLSTIVHLLRDPDFTSGNGLAATWSFVESNVAIICACLPPLRPLLVRIFPKLIPSRMRSYQRDKDSRSNSNPNNNKAAEAAAGQPPPTISKSRTRKSLSKRGSRNEPEHIDFDFLSVYGAGGNMFAPGSTVSTSVWGDAGSVRSGVENGNKDGDGNGNGGGEGDSGGEGIQIMREVRWDSVSVSGSAEGASHGTGGWGDVEGRLSEGTRRSSGAPFLHPQWVGGNGFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRW9</accession>
    <name>A0A370PRW9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_247558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRW9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="414"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="721"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="781" mass="82148" checksum="0B940752951EA375" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PS11</accession>
    <name>A0A370PS11_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M752DRAFT_274265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PS11"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDK44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="628" mass="71964" checksum="6715CFA484650304" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSB4</accession>
    <name>A0A370PSB4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_274370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSB4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Related to multidrug resistance proteins"/>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Hoof J.B."/>
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                <person name="Salamov A."/>
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                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
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                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
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</entry>
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            <begin position="1685"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1799" mass="196932" checksum="8AD2E91461E0EF43" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTX4</accession>
    <name>A0A370PTX4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_311765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTX4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="497" mass="56823" checksum="BAC2087B660D5350" modified="2018-11-07" version="1" fragment="single">MMSMFSIRNLGTAITSTMTEALCSWLLAVACVLLIANALYYSLFQNNSISSIRVVVRDFRDHRYYRPWAPKPIMIPARKRIMTELSETSVLSQRAVYSDLFGFKHTLNGVDHNEINTRKSRLLSRVLQVRGPTEFEKLYPYLLRNLKAILDAELSSADMQRGITSIRLALFGETILSRLMGVWFFGENMASDSLLRNALLNHPRQIKACSAAFQLTPRFLAPLVHAIITWRGSAMHLIQDRLINTITAGIDDLDEKPEIKKLTLLYHMVDLSAADRSYWTPERLSQSILGLWLAASHQPWVNLHAILVELCLRPEWQDLLRDEALQNQRNLARNMNELPLLDSFMRETARVNSLDRVAIRRKALKDYSFSSAPLSIAAGSILCVSSYDVARNEHIYPDPEQFDGGRFLTGRCKDTSRKFTDVSENHLIWGYGSLACPGRHHAAFMIKMVVVHIVTNFTLQLADPEAPRWWTWEDFRMPYASTRVLFSKRTTKTDAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUA4</accession>
    <name>A0A370PUA4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_273925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUA4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="683" mass="76270" checksum="54FAF93D384C776E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PUN0</accession>
    <name>A0A370PUN0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PUN0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK45907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="151" mass="17128" checksum="4EFFBCA5B928B269" modified="2018-11-07" version="1">MAQPANPQPSTALPVRTREQQRTRRKRGNVLDDRVHPNTSTALQPVRRQASRSPSPATDEESILAREQTRQRARGDLAKRDPAGQEMTQPSEEEDTGLKLRLELNLDVEVELKAKIHGDLTLALLMYMAASWHVPPRDTILSSYKRRPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV09</accession>
    <name>A0A370PV09_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_323801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="234" mass="26896" checksum="DE52547848A19826" modified="2018-11-07" version="1">MGREDQIEEREVLDSIFPEEITDISDTSYRISIALDAPENDVEETEQPVLLLQVTYPEDYPDVAPELELTAPPNAPKHPRLDISEDRDRLLETLQPTIEENMGMAMVFTLVSALKESAEELMAERVNAVHAEKEMEAKKAEEEENRKFQGTAVNRETFLEWRDKFIKEMEEEEKRKREEKEAEEKKSNKKGPGKEEKKLTGKQLWERGLAGRADFDEDEEDGMPAAVENMKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PV14</accession>
    <name>A0A370PV14_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caffeine-induced death protein Cid2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_273156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PV14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK46033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="202" mass="22824" checksum="4D3FC8C2A861B970" modified="2018-11-07" version="1">MSRASSTSAPQLTPQFCFNERLLRDFLRISRSTIDDSITQNLNALFTPARQGFDPSSTAIRQIDASEGKQIEPAACQSFKDKVLFPSWQVRSDVLNYCAGVATSPDPEDPDLILQQTESAEDREHIVDDRLDPYAARFLPREARTESLANLVRTQRGVEEIIRARTWGLVTERCGGPSEGWEEALNKWRENKQREQAPPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVB3</accession>
    <name>A0A370PVB3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_309656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVB3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="243" mass="26217" checksum="BECA2ABBA608E1D3" modified="2018-11-07" version="1">MKWTPEKDQLLLLKILETHSLSVDAKRVAEAWPKSLGPDMPTPRAISERLVRMRNTARESGGENGHFSIGKGLKNGSPMAKSTTNVASSFASVSTPQTLRISNARKGFSMKRKRDDDDDLDEDREEGEYTPTPAKVKGDGGSDTEIEIGLETPSKTVKGKGVSARSSAQLKKEVIDLESEADVAPVKRVRKASSLAPGMVEWKDEEDDGEGESSASEYVPKGEGEGAGVDSGEEFDDGDLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVU1</accession>
    <name>A0A370PVU1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_273397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVU1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="94" mass="11005" checksum="87BBEFFF354D081E" modified="2018-11-07" version="1">MASEKKDKLEAQIKSVDMTEDMQQEAVEVAIEAMDKYHIEKDIAQYIKREFDSRKGATWHCVVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWU4</accession>
    <name>A0A370PWU4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_262929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWU4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="163" mass="18013" checksum="43A0C0D6EB843436" modified="2018-11-07" version="1">MPYHHHSNMQQYSEALLASLPEGGNEQVPVNAAGLGWEEAGRYLSHESPGHDAIVLDILRIQGKGPLSRPKGLPFSVLDMVEFWINGFVTMSGTQRLNLSSFAKVASTRDYMDGLCQIAPFLFRATLENENRDLRSVNESDAEDPIRAMNRLSMVDVLAEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX61</accession>
    <name>A0A370PX61_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_272579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1304"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1437"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1468"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1494" mass="164961" checksum="F26FE5B6729A7779" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXQ8</accession>
    <name>A0A370PXQ8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_323412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXQ8"/>
    <dbReference type="SMR" id="A0A370PXQ8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="575"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="749"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK46965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="849" mass="91723" checksum="59B0E6D5E03D97BA" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY14</accession>
    <name>A0A370PY14_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_332352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY14"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="278"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
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            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="342" mass="37716" checksum="5E81D60004C1E9DF" modified="2018-11-07" version="1">MNKSHPTSTRPKRTRPTRRTKPKTKPASSIRSGLINRASPRPTSSSPPPSHPPSPRRKRPLLPSLRTGSPGSKDPALSIEEWLSLQLPTCLSPARPSRSSAQNETSPPPPYNSSHFYQDLSQYPDSFYLPPEFHNNPTFDFSSAAFPPVDTTSLFYDDSPPDTSLTAGSNSTINTALSSLSDSSYQDQIIGYPDPTTQHTSCATILHPHPHSLVPVTTAGPDLDPIDSLLSSPELSEELNLLASPGVNSLPEPESEFPPMPAVSSTTSSRAAAPPKEAPNRVKKRELNTLAARRYRQRRVDRMNQLEEELEAIKRERDELKMRVSKLEGETEALRSMVRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY37</accession>
    <name>A0A370PY37_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_262035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY37"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="246" mass="27647" checksum="42281514F39B1051" modified="2018-11-07" version="1">MEENPCQIQSGLGTNDLSTPLILFHDAGGTVFPYFCLGDLHRPLYGISNSHFDQGGKWDHGIRQMGVVYSHLLRSVIKSGDVILGGWSLGGCVALEVASRLMKLPQYTVQGVIMIDSVFPTSKVTDRYPRTIAEVAASFQLPTRMSDARRVQAQQCILYAHEMQRDWRPPLFPSGLPPTVLIRAADPVHLDPDAKPHYLDLIRNWTYLGWEEYDRSFIQSCLCHQTTTKIREACAILARPQQPNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYT2</accession>
    <name>A0A370PYT2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein Sog2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_208026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYT2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="991" mass="109495" checksum="998639A73814A488" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZ59</accession>
    <name>A0A370PZ59_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED8</name>
        <name evidence="13" type="ORF">M752DRAFT_323608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZ59"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1710:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK47194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="269" mass="28859" checksum="016C376F965B7C49" modified="2018-11-07" version="1">MSSLNQDQIKTLEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHLSDNRDLLSNIVAYPDASYPSRVPANNVALEQVLRTKLDPRVEDWVARGRRAGAPTTSSDAGAGGLGQYQTSSGPRLLSDDAIAELWDWAPVAANEEARKRNWGGNYTLEEREMGIENVVTGLSRVLEDDDEEDESDSEEGEGEADEMEVVGARRRSGAGAGLEFDIAAANTGSGANTGAGAKVVAPVVPLDEILRFMTTGAVPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZD3</accession>
    <name>A0A370PZD3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_271858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZD3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="176" mass="20459" checksum="7FF182AC9A3B5472" modified="2018-11-07" version="1">MTFEIYIPSSLTFQDYIAICQCARTFADGYDRKDKTRLRAALAPTVIVDYNKVLPHVTRETYEADDFVEKWLNPTNLGNKALATQHLLGAPYFKFASEEKIVVQWQQLASHGRWVEGQDKTRPVLCKIDETSDGRSWMQQTYVKVDGQWRIQVLEPEVLYHTGDFQKIRRPDEKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZI3</accession>
    <name>A0A370PZI3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gladden J.M."/>
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                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
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                <person name="Kuo A."/>
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                <person name="Hainaut M."/>
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                <person name="Gladden J.M."/>
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                <person name="McDonnell E."/>
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                <person name="Chen C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">ATCC 13157</strain>
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</entry>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="McDonnell E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="463" mass="51042" checksum="4279AEB34CFCB3C5" modified="2018-11-07" version="1">MAPRSSNTSKKPNKKENSKKKLSSSSQTQPRRNTSKTEPNHHQDHLNLSTTIPLTLQQLLLNVFKTALLTNGHNYLHNREETKKNDNDESGATTADSAEQQQEQQQLDIKSLIQTIKTHLYNRDFDSAFTDANEDLLRAYALRWSSSRALGYAGIFRALLREVVKPVSDHAATTSTNNVVCIGGGAGAEIVALAAAWRDFMDGAELRSSSARDEDQIADAVEAVSLDDGKEEEGSKEAVKQPTSTTTSTTTTTYPGLSVTAVDIADWSKVVERLSTAIQSPTVTGSKSHPAPLLPSNKDEEKKTPSFSVGFEKLDVLSTGEKELQGLFSRQGAESCSTVLVTLMFTLNELFSTSMAKATGFLLRMTDMLRSGTVLLVVDSPGSYSTLKLGKGGDGEVRERQYPMKFLLDHTLLSVAEGKWERLMSEDSRWWRRDAARLRYDVGEGAGLEDMRFQVHVYRRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0S4</accession>
    <name>A0A370Q0S4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_272237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0S4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="301" mass="34057" checksum="33A3B402588AB415" modified="2018-11-07" version="1">MEDPTTNHTYSPPLDSIFLLLPILLLPTIFLLHRIHKDYQAFLALGPGGTPSTPTGYLRICLLRLFTIRDPFEPPSLPLTLLPKTGLLNTSSLPQRQGPRPTVAGIAPQRQMTQKANPAMYETLSREIQHLVSQNPEALYEGTSCFEKHSTGMFCSSTDTPTSTQQQGGGTLKDRDISSLMMSRNQQWRHRRTCNGEVCHAHPSDGSLHLTLHPADVKVVIERGWGQRHPLTRESWWWCYLRTVPTGFVMIYAPRNQEELECVLKIIRAAAWWVSGEELVQQKTQKREGGIVRRQVVEGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0V1</accession>
    <name>A0A370Q0V1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_4936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0V1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="146" mass="15167" checksum="6522AC5FCBA1375A" modified="2018-11-07" version="1">MSCPPPASPIIPGAFDDSDDSSSTTDYGSDFSPEEDALLTDLLAKIAPDRHAITTTAPAEAAAHPPSSQVAPIVRDIEDQYADPSNSRVPRVLGREKPTWPQRNWANRPGGGGARAAAIPGYGRAASGSFPFPMAIVVCGLIGQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q168</accession>
    <name>A0A370Q168_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q168"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="140" mass="15247" checksum="CD9314EEFD289192" modified="2018-11-07" version="1">MIPQAATPDDENSDLIDTLFDSIGLHDLTKLNHWKSDNEPDVIDDSNSPTKTVTSQNNDVNQEDDDETDNGKDTNKDTDKVADDSTSNDNKKDSDDGKSSKGGRLPNPAADPSGFVKALMENIQDAFKDAVDSSDEHTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1G6</accession>
    <name>A0A370Q1G6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_272454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1G6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="168" mass="19063" checksum="A1570F0DAE99D3E8" modified="2018-11-07" version="1">MPPADLTPSLTISDIHSLKKDQALEILAQISRVEKKTFPANEAFSFGEELWRKKPNTKVLYVTRAPSAPGDVRPTLLAYAVYVRQKGIALLHKVCVGEAYRRQGVGMRLMNYIRARLQSEGCQQIQLWVDKARSPARSLYVRNGFKERDEIPDYYAPGRTGIKMVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q263</accession>
    <name>A0A370Q263_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_300060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q263"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="612" mass="69700" checksum="2B4B733B621E179F" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3L6</accession>
    <name>A0A370P3L6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_322401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851881">
        <property type="protein sequence ID" value="RDK36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3L6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="296" mass="32734" checksum="8EA6F3DACF34EB99" modified="2018-11-07" version="1">MESLTADPDTQVEVDLMILDYLLCMAIDQVLSPGNGGETQYAHECDISWSLKTINTIKAALLPSDILPKDMQIKTQILELAQLFSDGNGHPEPSRRPAVEPSQGDQRTTTENRSPIAQSERRPPQLHQSHENDKPPAHNSRDLALNRSYNTLVRFVALCGTAVDNLPDGHADTTAKLITEAALNDYHMAGAQSPGRYRECIEHVTACLREDLDPHADQANLEYLSTLLPPIDLLLDVSEGSGQTSSLGDTTTRLVHRFLTDLMKTLDPPILIQLERGRLGGLSREETQQLKDRIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P400</accession>
    <name>A0A370P400_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_311151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P400"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="507" mass="56468" checksum="55457E886E4BFEFA" modified="2018-11-07" version="1">MRLWKHDFRGRALIIAITMASCQAFLLLGFDQGVMSGIVGADNRFARDFNNPDAAMQGNITGLYDIGCVIGSIICYFIGERMGRRTMLMMGGFIMIIGTVILASSYTIAQLLVGRIVTGLGNGMNSSTAPVYQSECSPAAYRGALLTLQGTVTILGVVIAYWMDYGTSFTDSSYEWRLPLAFQAVFAICLILQVVGLPETPRWLVQHDRHEEARAVVAAIEDTTIDDPNVTKTIMDIQFVLEEEQKDGPFRVKELFTWGEVQNLRRLFITITIELGQQFTGSNMINYYGPVMFQETMNMSRNLSLILGGAMQCTYLVGSAIPVFLMDRYGRRTLLMVCSAGLCLCFVMVSILLSLDREDCAYGATVFIFIFQIFYGVGWLPVPWFYPAELNTTRVRTRMQAIASGWNWMAVFAVVKITPIAFDNIGWRTFVIFAVLNAVFIPMVYFFYPETKGLELEDIPLLFHKGGITGGVFTSKGGRTVTPGQHALEARVDQKVEGTVQQVEHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P487</accession>
    <name>A0A370P487_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysozyme-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_111021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P487"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016689610" description="Lysozyme-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22479" checksum="0E095B9101397BBD" modified="2018-11-07" version="1">MKSTSILSTMCIMPLLAYASPAGRIRARDNSALTVAQLEAIAPTSNTCDNPPAAGECATAEQAVPHITKSFDTYGVTSRAEQAAVIGLMAFESGDFKYNKNHFPGVPGQGTRNMQSPSYNSKYAASLPALAGQLSSVSGDPTGVLNLLLANEDYDFGSGAWFLTTQCSASVRSQLQSGSEAGWAAYITDCVGTNANDDRKAYWTRATQALGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4D4</accession>
    <name>A0A370P4D4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_225796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4D4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="394" mass="45258" checksum="2A0202C21DC366AE" modified="2018-11-07" version="1">MSQNRPGVFSSLRMGEVVREKVQDGLTGETKEISYSQCKIVGNGSFGVVFQTKMMPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPNTGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRRAPHEAIDLISALLEYTPTQRLSAIEAMCHPFFDELRDPNTRLPDSRHPNGSTRELPNLFDFSRHELSIAPAMNSRLIPPHARPALEARGLDITNFKPLTKEEMIARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4I8</accession>
    <name>A0A370P4I8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_280135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851876">
        <property type="protein sequence ID" value="RDK36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4I8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="8672" checksum="90CAECFE5270358E" modified="2018-11-07" version="1">MSSESPQVDMAPPQPDSGEQNATPDADTAKRKAEPANGTHTRSKRNRYISIAWYDSARCHPPMLTLSHHWLSTLPLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P548</accession>
    <name>A0A370P548_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_107108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P548"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK37003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="107" mass="11494" checksum="66BAFFEEC443CE6A" modified="2018-11-07" version="1">MSPQFPSNAPAATEKLGNQAAKLGHQIRGREGATPACQFRPATAPTNYLSSLRLPFLRRTCTLCRHIPPVPCPIMLIHGPVLESPSLVMSQTPKHQCQKCVIVAGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P565</accession>
    <name>A0A370P565_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative U6 small nuclear ribonucleo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_225428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P565"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="83" mass="9493" checksum="21F3285ED8B653F2" modified="2018-11-07" version="1">MADTEDAGTSSVSEPLDLVRLSLDEIVFVKLRGDRELKGRLHAYDSHCNLVLGDVEETIYVVEEDENEQETLRVRRSIHLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5K6</accession>
    <name>A0A370P5K6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M752DRAFT_279898</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5K6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="244"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="539"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1007"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RDK37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124838" checksum="5675DCAE7AB2EB9B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Y1</accession>
    <name>A0A370P5Y1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_224462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5Y1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="465" mass="49875" checksum="9D43ED44043F5088" modified="2018-11-07" version="1">MFYSGSLQEGIAAAVAESKAVVCFVRDDEQASTEWEESYFTFDEEVCSTFDTHISASANATQLAQLLQSRAVLLRFTKGSQEAGFLASFCPIVKFPTVVVIKNGMMCDYFVPDISKEDFRDRLLAKLDESRAPVQQDVGSAGTAGDETVSAPVASDAPAPAPVSSVPILAPAPVAEPAPTPAPAQPAPQPSTTEPEQPRDATIREGKRRVDDARVEQHPTQESKPKPKPKPTPKEKPSAPAAPKEPTTEPAERRQPSPPKQYRLQVRLFDGSSVRSSFTPTQTIRNDVRPWLDSQMEERSPYNLKHILTPLPNRTLTIADEEQTLAELGLGSSANLVMVPIQSYTEAYSGAGASLPVRAVSSAYGLVSSAVGTATGLVGSFFGYGTTQSSGNEAAPAPGTASSGSNDAGRRRVNASRGPIIRTLRDAQNEGDDRQFYNGNQCYVCIKLLLPLLVAKHPVLSSVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Z7</accession>
    <name>A0A370P5Z7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_94790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5Z7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="147" mass="16507" checksum="D362975737C6CEC2" modified="2018-11-07" version="1">MALKRINKELTDLGRDPPSSCSAGPSGDDLFHWQATIMGPGDSPYSGGVFFLNIHFPTDYPFKPPKVNFTTRIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6Q8</accession>
    <name>A0A370P6Q8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_224096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6Q8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK37551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="368" mass="41032" checksum="8AB48088A59277C3" modified="2018-11-07" version="1">MDFYLRCNSLKCRAPLKERAVVTTCSHIFCLHCAGSLGLSHPTANERSCPACQTVLVNPDDAVATALNPTEDYKTSVLSGLDPNTIMECAGRALLFWTYQTTQEIFYQEFLAKTLTEKYTNLNTQLDKVVHNANSEISALQARISDMETAQDQLRKKNQELVDMYREKCKKFTQMTNLYNILKSRAMRSQMQTAATDTVSQALDSLTASRNNPTGLVPGHQESSRPPHTPMSRQLNVYPVNQEGVEQIHRHQRSGTGSSKGNKQKTDIAAMPPPSRPIDSRSKYDQPGATPQHRTRLVGLSRPSTGRTALPHDSIMLQRFQAEAGPSDTLVDTRDPTRRGNIGMQLHSQRHSPTNCPRLGSFFDSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7U5</accession>
    <name>A0A370P7U5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_297642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7U5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="245" mass="27590" checksum="0AC502E12D65F6EC" modified="2018-11-07" version="1">MSELIYVKPLSNEDYSMPNLLILTDFQSPALNTGEMKIPRLHPWGASAEIFEKQISLICAMISESHDYVFLDGSVSCGLQQVRRSQLPGSRPAVLGPRGYDRSLIISARDTYEMLTALPLSFFTIGSPPNLPGPFYNWYDVLSSSQVKDAHDLVKDVIEDDGSFDGVIGFSQGALLALSILYYHEVCHLDHPPPFRFAIFFCAMLSISPDPMFNAGIVAKYSKYYKQVRHYEQSDKDKTKMEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P835</accession>
    <name>A0A370P835_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_240049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P835"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="778" mass="88173" checksum="9B9D8AE712E44146" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P866</accession>
    <name>A0A370P866_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_308065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P866"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK38204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="352" mass="39738" checksum="8D82C4754CA4CEBE" modified="2018-11-07" version="1">MQRKLELVDFSCLYEFCTYLLGAAGALLECDVVKTRQSNTRAHKEEWAWKDLVLTIWLFTADDFTTFVIPETAFGVCAALSGPLLTDDNTPDLLSVVSRIPIVMLWNWLNLFVFNLANQRHPDSVAEDKINRPWRPLPAGRISILQTRRLLLLAIPMVLASSVYLGAWEETALLYTLNWVYNDLSGGDDGFILRNVLLALAFSQYNKGSLRVATGTGFDILPRAWRWIWVTSAVIGTTMHIQDIKDVEGDRAKNRRTMPIVMGDGPARWSVAVPVAIWSVVCPAFWELDVAGYVLPVAVGMTIAGRILLLREKAADKRTWKMWTAWTAVIWMLPLFKNNSVFVRFGKKFGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8C5</accession>
    <name>A0A370P8C5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_222317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8C5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="317" mass="35488" checksum="D36A9B94B7A8CDFA" modified="2018-11-07" version="1">MARAAMSKLSWESHVLRPVQNAPPAIIPTLIYGTAWKKDQTADLVHQALGAGFRAVDTAAQPKHYREDLVGEGIRRALQDGYVRREDLHVQTKFTSVNGQSPDNMPYDPKASVTDQVHASIKSSLHNLRPSSTADSVNDAYIDMLILHSPLPTMSQTLEAWSAVESYVPHQVRNLGISNTTLSILKELFAQAKVKPAVVQNRFYADTQYDVPLRAFCRENQIIYQSFWTLSANPELIRSDAVQLLAHEADISPAAALYCLVLGLGYTTVLDGTTKRHHMEADLAALQKIERFTENQPDLWQRILKRFQQLTGDQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8E4</accession>
    <name>A0A370P8E4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_240229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8E4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
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            <end position="271"/>
        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="530" mass="57891" checksum="F88CA057DDCA4F89" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8H5</accession>
    <name>A0A370P8H5_ASPPH</name>
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        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_286462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8H5"/>
    <dbReference type="Proteomes" id="UP000254937">
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    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
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    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="41"/>
        </location>
    </feature>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="263"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="342"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="42177" checksum="ABE821FF12EC160F" modified="2018-11-07" version="1">MTASGKPLVVIDESHHAGIVIVVGTLALIMTLICLIIRVYVRTILSPGFGRDDYLLFVATAFAIIQTSLVMSNSAKGFGTSIRLLSSDQVVKVQRTTAATDTLFLITVFLSKCCVLGMLSRLTPQRIHHFVLYGVLGLSICWVLSSVLIILVNCELNRPWARPIDHCTGLFQKWEYIGVMDSIIELMLFLFSILLVKSLQMPTTRKLVVLSSFAVRLPLIIFTSLHLYHLQKYAYSMNPTLDIIDGYVWTQMGMNYALIVCISFCLAPFMRAISVTYGIAGEVTLGTSSARSKSGKYGRDISKQSQSYVLQSMDNQEEAGHGMSNPRHSQPTFVPEHYGGMLSTTAYDGSSRTDGDSVASSESTKMIIKKDVEYTVTHEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8X6</accession>
    <name>A0A370P8X6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8X6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="186" mass="20190" checksum="7EDB601159F35081" modified="2018-11-07" version="1">MDTIKQTMATTPNHTEEEQRKLYDSLPAEQRNKQSFTEWVKEAYNEQYEKWMPWLEDQYLKWFGKGDNKASYVTKDNLSKTKVTGVKQADQIQDDVNNLVGNQLGENGLLAPVGNMVSKEGLNRAERGGKDENGSYGGPLGGATDPIVDNSKKAGQGLATGIQSAGSSVASGARSWGSAIPGFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P908</accession>
    <name>A0A370P908_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_279063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P908"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK38474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="398" mass="44392" checksum="B6A23DF0F6190281" modified="2018-11-07" version="1">MSTPFAKLPSSASISPTPFTVSIPDEQLNDLKTLIRLSKIAPPTYENLQSDGRFGVTSEWLSSMREKWVSEFDWRTFEARLNTFPQFTTEIEGLTVHFAALFSQREDAVPIALLHGWPGNFVEFYPILQLFSEEYSPETLPFHLIVPSLPGYTFSSGPPLDRDFGLVDIARVVDQLMKDLGFGSGYVIQGGDIGSFVGRVLGVSFDACKAVHLNLCAMRAPPEGLSTESLTAAEKEGVARMEKFMTNGLAYALEHSTRPSTIGHVLSSSPIALLAWVGEKYLQWVDEPLPATTILEMVSLYWLTESFPRAIYSYRETTPTASVPNGATMLQNELYIHKPFGFSFFPKDLCPVPRSWIATTGDLVFFQDHTEGGHFAALERPRELKADLTAFVEQVWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9U9</accession>
    <name>A0A370P9U9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_75300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9U9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21817" checksum="98E87F3685D54801" modified="2018-11-07" version="1">MSNPHLPITITSTLTILLLLVSFSLTTYTLTTYLHLAHTATSLVPKAIVHDTAILATTSYHIFTTILTSATFITIFFLFPRITKSKGGNPSWIQKGLTCLATLLLTTSLLAFTIILATRKMSFGDVGPHVTVYLDEGLGEKQLVYRDDGRAVAGVVLGWVGWIGASVLGGMMMLGGKKEVGRGEMWVDKVEVEQESRAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9W0</accession>
    <name>A0A370P9W0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_278696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9W0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK38774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="693" mass="78577" checksum="5DF730DF5175962C" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAA8</accession>
    <name>A0A370PAA8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_239059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAA8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="17522" checksum="9FC4785E74E7E479" modified="2018-11-07" version="1">MAIHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVTQLVLSRRTRMCNFLEYKDTKVVYRRYASLFFIAGCASTDNELITLEVVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDMEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAJ5</accession>
    <name>A0A370PAJ5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_305844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAJ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.670">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK39228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="206" mass="24404" checksum="DC065BEF34B354CA" modified="2018-11-07" version="1">MAAPTWPLYPLLSTACSRSSVTILGGSRHGVWMKAFLASQRASGSGWPTRFGRFSRFSPVASCPDDRTRSVAKGDVDIWTRTDAALELRQRLRKQRVAVNWDDFDALVSRLYQVYEYYYYYYYYYYYYYYYYYYYYYYYYYYYYDGLTGNCGNMAPNIIKILKLAVVDERREVRPNSAAQLFVSSMVDGHVMRGRSGRRNGNSQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM0</accession>
    <name>A0A370PAM0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine hydrolase FSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_321075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="3">
        <location>
            <begin position="278"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44626" checksum="46950EB15FFFB3AA" modified="2018-11-07" version="1">MRFLCLHGIGSNAEVFKTQLSAIQAALGSQHDFVFVEGDIPSEAGPGRLASPRSTNEAHLCTGVYGVAEGPYFSFFNLPIASQIYDAFELIDQALEYDGPFDGIMGFSQGASVAASYLLRNQGAHLPFKCAVFFCATAPFNVESTPFRLMDDGTFRDEVTGEDISAEIAANIPDLLDRKRFPSYGKCMIRPYPADGSIKIALPTVHVYGRTDGYYPQSRNLAEMCQSFDREELEHKRGHSIPLEQGMTSRIVDLIRRLIHAVELHMGSPQDIEQALLGSWSLLDYRSQLQDGSETFPMGKGARGVINFNPNGRMSVQLQPAVTKKVKETVHDLLAYTGRYWVETQPDGSVMLKHHLEVCSWPEGDGSYQLRTVELSEDQLVLSSPAPLNVEVNPLVTYDFGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PAM4</accession>
    <name>A0A370PAM4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_268856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851861">
        <property type="protein sequence ID" value="RDK39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PAM4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK39236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23634" checksum="CD8B808768482994" modified="2018-11-07" version="1">MPFYNNLYPTFSFSTSSPPVLAEPGAGLDTKQETNVGEGSSSGRRTLCGLRRRYFFLGIIVALIVIAAAVGGGVGGSLASRKNSSSSTTNTWATPTTTTTTSTSTSTSTNETCPASNGTTITVQGIEYTRLCGIDLCSSTNGCTEMTISDDTLKDFTTESLVKCIQQCESYNDIITGSECQGVSWDANAPASSNHTHRCFLKNATSIRKSAPDGWTIMSAVRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PBQ6</accession>
    <name>A0A370PBQ6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PBQ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="319" mass="35266" checksum="68F11A797E1F04A4" modified="2018-11-07" version="1">MTRQWSPLSDGLLLLTLACMTVFAALLIQYIVAGPGPGTFDLNEFAADADIGGMVWAKAFLKTLYVADLFFMATITFVKLSVLAFLHGLFKVSRIYRVLNYVTAALCVAWFLIVLFVNVFQCHPIHMLWDAMGAAEYCIASGRLWLGMELTNLFLDVIILFLPVYVVTRLQLSRTRKVQITGIFLLGGLVCIASICKLSYLWIPATPQVVRAPETMVWSSVQLGVATLCACLPTYAPLFRVARGKMSTVKTPTAPYPYGSDNTPRNAPAGKSAPYRRVEDPLLSTQQTEITRGDGESYKMDQLGPCHIYVKQSVDVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCA7</accession>
    <name>A0A370PCA7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_278222</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCA7"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK39799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="969" mass="109299" checksum="BEDEE3D498A59E2E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PCK3</accession>
    <name>A0A370PCK3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_45866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK39915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PCK3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK39915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="93" mass="10444" checksum="FC5A3C84BDCD1890" modified="2018-11-07" version="1">MIQRAHRGPGYRSVSDSFVPPAYNIPNRPWSRRSGGAADAGLAPLMFGLCLNSRQTRFSLVSGETCSKSLFVIFYFFLFFIFICKFSSNSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD01</accession>
    <name>A0A370PD01_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_278195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851860">
        <property type="protein sequence ID" value="RDK39774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD01"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="321"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK39774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="797" mass="87630" checksum="FE34228D7E842305" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD07</accession>
    <name>A0A370PD07_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M752DRAFT_337824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851859">
        <property type="protein sequence ID" value="RDK40071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD07"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="60"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDK40071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="56801" checksum="444E8582B3C0C27E" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PD89</accession>
    <name>A0A370PD89_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_39480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PD89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="280" mass="32175" checksum="CC594F4DC756FC3A" modified="2018-11-07" version="1">MDPSVWYHRDLGSRLSPACRFVYNRWSSIADTDLSAHLHRVRDRAWPVGQYPCIGQWMFLLPGLAGFPEFPSILDLVRQPREAIVLDLACGLGQDLRLLAAHAAYPDGAPTARWWAVDLEPRLWELGYELFRDRDRMAAHFVAGDFRTLDITAESSPLAPLRGSVDLIIANQFIHLFDLADQREVIRRIIALSHPGTTVVGFQQGRRQPREDVRPWGTMFFHNRDSFVALWESGQSETATEWTMQVREVDLQRDWGLQEEDVTWMPADQGGLEFVFVRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PDN4</accession>
    <name>A0A370PDN4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_277626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PDN4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="574" mass="62344" checksum="DBAE461CA0CE3259" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE48</accession>
    <name>A0A370PE48_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-threonine protein kinase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE48"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40700" checksum="30A1111EE4011FC0" modified="2018-11-07" version="1">MPLRVTSAPVSGIKKNRKPAISRPRASPFAAHARRKPSAPSSSGTSKISSEQDECGQGPLPDLGPSRYISETASVTDVVEALQYICNSMFDDLPRRAGMNSTRIAEVLNFRRSLPPLASVAHVHTLLEAPTKVEKEIMELVRAGRVRRLIVPGRGNDAAGLGDCLVLSEEWDGLVLDSPALEAPLKEKFLALLGRIGNTCAIPGAALTPPECMALVRAGFLVSSSSLAKGSSSLASLPVFPATSPSPASASRSGAYTLSEVGANPRSSSTTATLFLSLPNTGPYLRLLSAGRSHLLSLLKKSSSSEVPVYLLRDRWDGAVESEKSFSVAKRARGEFSGILPGRTKKYKELYGMNFRWVLEEALGAGLVEIFDTGSVGPGVRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE53</accession>
    <name>A0A370PE53_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_218621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE53"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="648" mass="68437" checksum="55BA6A1BF1F8F791" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PE89</accession>
    <name>A0A370PE89_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_295412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851858">
        <property type="protein sequence ID" value="RDK40224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PE89"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK40224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="139" mass="15329" checksum="0EA80BEAE65D44D1" modified="2018-11-07" version="1">MAMALNIRCYVNLEQEMNSMQRILSVATTTPTERDTQMDLSLPEGCSQEEPLEGSGLAVHHASHLPPVLKRISFSIALNTRVDVIGRTGVGKLSLVLALFRFLEACHGQISIDGIGISRVPVARLRNRLAITPQYPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PEU3</accession>
    <name>A0A370PEU3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_328108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PEU3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK40706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="337" mass="37951" checksum="ED412DCFB81111B4" modified="2018-11-07" version="1">MRLSYRIGAAALIILAIILIKRHLDLVQDDARVQSGWSFSSFSAESAADGSSNNVNSGNDGVSTPKNSKPILTGSDNSNSNGKTKGSSDSAVSRPLYETTPIIVPNDRVIVMAKLSTEDTSWVSNDLAEWRNVIYTVDDVTAPRHTPKNKGRESLAYLQYIVDHYDDLPSTIVFLHSHKDGWPGAWHTDTMAYSNVDSIRALQTDFVQRNGYVNLRCQQTPGCPDEIRPFRDPPQFGKTAERVYAQAWVELFNNTNVPDVVGVACCSQFAVSREQVLKRPLEHYTWFYDWVLNTGLSDDLSAHVMEYTWHIIFGKDPVYCPDAYQCYQDVYGNPYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF28</accession>
    <name>A0A370PF28_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_37553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF28"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK40783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="378" mass="42092" checksum="B14C8B111664882C" modified="2018-11-07" version="1">MSRTYATPAAIITISILFPVLGTLTVILRFYTRRKTKSVLWIDDWLTLPALGLEYVLAALLLWGTTTGSLGGLLPQPDDPRPDAYIFSNSDQQIRLLQIQYVADIVTVWAFGFTKLSILYFYRSIFCSRRTIRTAFHSVTMCMTVLASVWTVAFGVGTIFICGAHPVNAWGTIAVVTTECTVQVPIVEGYAISDFIMDVIIWLLPLPRIWLLNISVRQKMALGLVFLVGLLAIAASATRMAIYIAHLINPFAQSDGETLVTYLLFWTMIECGLGVIVICLPSLRPMYKKRELNSLINSFKRYLYRIPTSTTSSALRNNSLNGLTNSNSSNVNLVRPWHPGPTTSPAVGHNASMAQHPSNTEQRIQVTREIELIRLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PF31</accession>
    <name>A0A370PF31_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_277269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851857">
        <property type="protein sequence ID" value="RDK40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PF31"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="627" mass="71352" checksum="FB47C75AC846DF14" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PFU8</accession>
    <name>A0A370PFU8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M752DRAFT_302538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PFU8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDK41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="463" mass="50737" checksum="7CEF58D9F27D5044" modified="2018-11-07" version="1">MGVDMFQAIQEIRQALGEDGISTDNDDLKDHGYSEWSSINIDRLPTAVAYPKCTEEVAKIASICHKYKVPMIPYSGGSSVEGHLSASFGGVSIDFLNMKNIVAFHPEDMDIVVQPSVSWMDMNEKIQDSGLFFPVDPGPPAKIGGMIATNCSGTNAVRYGTMKDWVVNLTVVLSDGRIIKTRRRPRKSSAGYNLNGLFTGSEGTLGFITEATLKLAHIPEETGVAVTTFPTMRAAAKAATQVIHQGIPVGAVELLDNVQMGVINKMGGTGREWKKLPTLFFKFSGTKVGVDDNIQAVRRIVDQNGGSDFEFEQDKAKQATLWSARKEALWSMLCMRKSGNEVWSTDVAVPLSRVPDLVDISKRDLDDLGLFGSMLGHIGDGNFHETILFDGEREREKVSKAVHDMVHRALEMEGTCTGEHGIGLGKKEFLVEEVGENTLDIMKAIKASLDPHWLMNPGKVFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGM3</accession>
    <name>A0A370PGM3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">M752DRAFT_252676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="258" mass="28937" checksum="208765275991C1B6" modified="2018-11-07" version="1">MAEEDNFDTGAMFEDPEGFYEPEPEPTFAEHHMLSGQKVRVRLVGSHPLYGNLLWNAGRTSSHYIEERASTLIEGKDVLEIGAAAGVPSIVSAILGARTSVMTDYPDLDLVGNMRYNASLAAPQIANPGSLHVDGYKWGNPVEPLLAYLPAGATGFDVLIMADVVYSHREHPNLIKTMRETMKRTKEAVALVIFTPYEPWLLPKTEKFFPLAEESGFKVTKVFEKLMDEVLFENDPGDERLRRTVFGYEIRWADEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGQ3</accession>
    <name>A0A370PGQ3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_319619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGQ3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK41359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="414" mass="48061" checksum="E13879346040BCF8" modified="2018-11-07" version="1">MLSSLLRSLTHLGRRWKPLNFPNSNFVRIPNWHNIEEETLPEYTASQYYPTRIGEVIKERYQVIGKLGYGSTSTAWLARDMENRRYVMLKIFIEASSMGQQADIELNMYRLMEQSPPIHPGRDAIRTLLDTFYIDGPQDKHRCLVHPPLWESVLAFLRRNPVERLPSAVIAVVLHRLFLGLDFLHTECKIAHTDIKADNIMFGIKDDSVFTDIEENELQRPVPRKEVDERTIYMSRELKVPKGIGAPVLCDFGSAMVVNDEYQRVFIQPQIYRAPEVILGVPWTYSADIWNVGCMIWDLYEGGSLFTGQDPVDERYRSRAHLAEMINLLGPPPASLLTQGELRDKFFSSEGAFLHPDLLTDYVPLEERETTLEGEAERDAFLRFMRKMLQWEPNRRSSAKDLAEDEWIHSHMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGR9</accession>
    <name>A0A370PGR9_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_277133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851856">
        <property type="protein sequence ID" value="RDK41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGR9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="125" mass="14858" checksum="ED60F84BA86D5EAA" modified="2018-11-07" version="1">MDPEFLTWNGPSILSPLTHPEDVFRYASAMLSYPVDCSEMHLTVVHKYTLESVDVLPFFLWRVECTPCNLEQCRQQICQVIRSYMRAIDHADYWIRMFVWPRDERERDTLRRSGVFSGTDPKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PGX3</accession>
    <name>A0A370PGX3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_266962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PGX3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK41441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="282" mass="31434" checksum="B07D1DE4C01AF9C0" modified="2018-11-07" version="1">MATGWTAYAYYPSVGGAAVMIMLFLAGVIVFTYQLIRTRAWLTIAALIGGLFETVGYIGRAMSGNQSPNWTLGPYIIQSTLLLIAPALFAATIYMILGRIIALVHGEHHSIIRLKWLTKIFVVGDCLSFLMQSSGAGIMVQSKSATDNTGENVIIGGLLVQIIFFCFFLVVAIIFQRRIYRHPTVRSESPMIPWRKHFFSLYASSFLILIRSIVRFIEYIQGQEGYVITHEAFIYVFDAVPMFLVLCILIRFHPSEINGLLGKSRVAAVGYGLRFVDVSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PH49</accession>
    <name>A0A370PH49_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_336630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851855">
        <property type="protein sequence ID" value="RDK41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PH49"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056669">
        <property type="entry name" value="DUF7767"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24962">
        <property type="entry name" value="DUF7767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24465">
        <property type="entry name" value="Tri-helical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7767" evidence="4">
        <location>
            <begin position="497"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="587" mass="66976" checksum="DE0FEA102C173AB4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PHT4</accession>
    <name>A0A370PHT4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_276486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PHT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="108" mass="13006" checksum="1085066099A1371C" modified="2018-11-07" version="1">MMFKPSSPLFSGLLWKIPWRLSQPQKARQRKRLRGVDRVVDTVSAALERNGYTTKAVERWYREMPREEEMLPKDKYTLFDKKEKKYRKGIHKLPKWTRVSQRVNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI06</accession>
    <name>A0A370PI06_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_20043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI06"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="279" mass="31907" checksum="00B9360E32825D78" modified="2018-11-07" version="1">MTHHSSKAHMDVVLDFAAELTNSLVIDQKKPHLGLDDKILAQLDRQFKHFPLLPASPSSPTRRGFDQEGTKLWNICMQLMTVYRDRSEDLLLACKVKAFAYAMLDYAAPYQGQGSNRALEAAFSIAMTCIDNDCLSLSQKIIEVAAVRLDKLERYESDVENSKLQQYTIEYYMIRAHLAWLQGRLDIAEHLFSKIPVSDNGRGQERVMDICYKIGNCAISRKQYDVSMKWLERALRACESIRHMQQASILSNKDKELLILHASGRVLLVDDKVKFVHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PI39</accession>
    <name>A0A370PI39_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_336240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PI39"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="304" mass="34024" checksum="4906857F5A63A37E" modified="2018-11-07" version="1">MNNNMNNNMNNNMNNNMNNQSQPQSQIPMPPPPQPQPEPTPLIEILICINAHGTLICIQSNNAQPTSTAIPIETIIANPTSYIFAFRDPIALHYAFSNQATYSLITRHAHYIRLYLLHDLQIGYRPSSPTPMPLSPLNIDNLFFYDSAADPNTKYITPPRIFCMPLVRQPQRMDNNRVCTISWPGFDALMNNWRYACRAIPWGHDIWYLVFNLASRGARVPQGVRRSLQMLSTAVCLKERVKGRFRCVVEGCSRGVVERFDEFLVANVAVMGWSVVGDDDEVRVEGWGDGGGGGAAAADCVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIF8</accession>
    <name>A0A370PIF8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein TMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_235239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016777841" evidence="8">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK41977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="478" mass="52585" checksum="38841580AC639419" modified="2018-11-07" version="1">MGALLSLPLLALPSASTLITLATSCCGAATCSAVCSACGKFQNSMATRIAYAFILLFNSIISWIMLTPWALKKLQHMTLDYMEIRCDGKECYGWVAVHRINFGLGLFHLILAFMLLGVRSSKDGRAVLQNGFWGPKIILWLALVVASFFIPESFFFVYGHYIAFICAMLFLLLGLILLVDLAHSWAELCLQKIEDSDSRTWRGLLIGSTVGMYVASLVMTVLMYVFFAHSGCAMNQAAITINLVVFLIISIISVQPMVQESNPRAGLAQAAMVTVYCTYLTMSAVSMEPDDRHCNPLIRARGTRTASIVLGAIVTMATIAYTTTRAATQGIALGSQGGHNYSQLGSDDNEHGLVTQQPTTRREMRAEALRAAVESGALPASALDDSDDESDEYDTKDDEKGSTQYNYSLFHIIFFLATTWVATLLTQNLDPEAVDDFAPVGRTYWASWVKIISAWVCYGIYLWTLIAPVVLPDRFDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PIM7</accession>
    <name>A0A370PIM7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_336432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851854">
        <property type="protein sequence ID" value="RDK42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PIM7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like"/>
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    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="248" mass="26733" checksum="51966CB17BFD5506" modified="2018-11-07" version="1">MFKYSLACLALLATGCLSSTTTTTTSKPGYSRNITSTVTDPSFSFGQHYAVLNLDLIDGLVANVNTTKAGQLWIDNVANWIDAVHKQDPPPLSIFTRIFFSNTYRPELGNAPFASAVTSLGNATASSPDSQIYSAFKTLDNWDVVLQKARYYAGAGNQLEEILSSQNIDTVILSGIRTSGVVLSTALRLLDMNYNVYVISNNTIETPSTYAPLNQKIILEGILPGLPVNVITIEQAIGALNRSGPAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJ79</accession>
    <name>A0A370PJ79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJ79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620932" evidence="1">
        <location>
            <begin position="20"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="616" mass="64205" checksum="896EC9449CEE8208" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PJF8</accession>
    <name>A0A370PJF8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_283730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PJF8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="468" mass="51583" checksum="90C38EC325B8860C" modified="2018-11-07" version="1">MAYDNAIFTSESGDLKISGSIDVNAWVEDPNHPRNWPTWKKNAQILMVAFHCMGATFMTAGIIPAYDVMSEEYGVPVESATYLTATQILLLGITPVFWKPITAIYGRYHVFLFAVFGCMLCNIGGAFCTSYGTQMATRVIAAICVSPPLGIGSGVITDLCEPHERAQKIGWWVLLLTLGTPAGPLIMGFVSGHLGWHWVFWILAIVNFVQFMLYVLLGDETIYLEEGVPQTRSPGSFFNKFIPRRLDPRPLTAYHFIEPLLASRHPRLIIPIIAQTIVFCYGNIALIVEMPIAFGDKFQLDEQQVGLQFIGIIIGCLMGEQLAGPTSDWFLRAIVRRKGSHRPADRLWLSYIGFSTVICGLLVWGFQLDNASSTWNVTPLVGAAIASFGNQMIGTILMTFSVDSHRELATDIGVCLSVCRQLYGFVGPFYFPAMFDTLKFAGAAGVMCAIIFAVAVVPTIAIQFISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PK63</accession>
    <name>A0A370PK63_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane associated DnaJ chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_251805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851853">
        <property type="protein sequence ID" value="RDK42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PK63"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="356" mass="40084" checksum="9BDE094EB3A3BD12" modified="2018-11-07" version="1">MSSLLSFFGWAVLPNYVTSIVQSVYYGITIRAGEPRPQPGTPRYARHRRRIYILVVTSYLLYTLYETFHRVQVAGDFYRALGVSPFADERTIKSRFRRLAAQHHPDKVGGAVSDSYFVYLRLAQDTLLDPVKRVAYDMYGPDMLNWGDKRTLQEFVMAGLQRSLPQYVIGLVTIVVLQFTYWSEWGRYWRYFTFAALVTLESILLTRPAAVLLPWSYIPAGLQGLLGFSSKGPEFYLLPFQILTLAQRASVTLHIFISQVTPPEISKRASSAPGDRLHPQTMQKLGQLAQLSRATDGEATRLLQLGFAPFKGDREGVTALRKGMKEALVLGSVRASPGVQQAVGEVIRRKKQGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKS0</accession>
    <name>A0A370PKS0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_233612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKS0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="706" mass="79364" checksum="91D918D5DFC3FC02" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKT4</accession>
    <name>A0A370PKT4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_292985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKT4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="109"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="229"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="466" mass="52453" checksum="77CB2A2745DB179A" modified="2018-11-07" version="1">MSDVAETKPDPTTNAPEGAEKPEETTTTATEETKTEEKPEESKSVTESAAEAVKDTATKTTDSVFSMFGGGPKKEKQEEPEDAKDEPSGSSKAQKGEDEDEAPESPDVHFEPVIRLTEKVETKTNEELEEQTFKMRAKLFKFDRDSKEWKERGTGDVRLLKHKENQKTRLVMRRDKTLKVCANHYIVPDMKLSPNVGSDRSWVWNATADVSEGEPEAQTLAIRFANSDNANLFKEAFEKAQKENEKLLNLQNKDSGVEGFPLRSWSIEIYVVNEHGEQVPANVFDKVTYTLHPSFGDRAIQTFKNPPFRISEEGWGEFDMQIGLTAADKEHFVTHDLNFAQPRYESKHVITFKNPKPALLALLRESGPVPGDENGVKSKRAAAGEEGSKKKKRTEKSVDMDKLADGLQRLGEDDLLQVVQMVHDNKAPDSYTKNDVEQGEFHVDLYTLPDTLIKMLWDFTQEKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PKV2</accession>
    <name>A0A370PKV2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_318967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PKV2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="524" mass="58503" checksum="B03E4FADA176FE6B" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL73</accession>
    <name>A0A370PL73_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_265808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL73"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="274" mass="30489" checksum="193BB263A91708AC" modified="2018-11-07" version="1">MDLSSLEGPPIADTRFTVSPRRANVPSIRLDTSTPVSPISPLTPHDLPPRPSSTDAIFSPVSESEYSYALFQQEPEANLNLWQRCHSPQPPVTADEHEYQQQPRPQPTLNLPPPPPSSSFSLHPWSSRTRSVSDLTPHQSPIPMLSTTTTTTVTTQAVTTTITTEGNRLVWLEKEKLWFLKPSPCPSPHLSPDYAVTTRPTPDAHYAPYRPSSFHGQVHLAALAQRRDVPPPYGRHILDRPLPPLPTDDSENEGSCGSRWTEVARRRANRAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PL79</accession>
    <name>A0A370PL79_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_318873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PL79"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="361" mass="40459" checksum="AD84D435CBCAD7D1" modified="2018-11-07" version="1">MTGPPLDAFSRPMRSGLFCSGFLMYTKLWMYAAGVKIRRSGWVHPYFYGTTRWVRALLIQDPPAAENGEFIFTMLMDVDSRCSTSDACFTICCCIMSFPYKKVLLIGATSGTSLCQSPKREVTGADTATGIGRDLATSFIQHGRFVIAVGRRQENLDAFVQEHGADKAAAFQLDTSQLDKIPLFVKQCSFMLTVLDSDRVTQRHPDLDCVFVNSGIQRRSVFSEPEAINMAVIAEEMNGNYISYVALTKEFLPFFQSKKDTPTSFIYTSSNLALVPILRCSNYCASKAALHHWILCLREQLKETNIRVIEVFPPIVESNSPFSCSDQIPVGLSNIAFNTWEQQRQQAFFHVVEMMKKSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLJ6</accession>
    <name>A0A370PLJ6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_335793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851852">
        <property type="protein sequence ID" value="RDK43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLJ6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="277" mass="31706" checksum="BEF7EE475660BB51" modified="2018-11-07" version="1">MPHRHIDTTKAAWLYPLRGIYYFASHRYLWPLFKTRLIPIVLLSAFIYVLLFLFAYLPQVAFLSIFQGVGAWINGAFLVLGEGAAIVAALFEAFFVDETLVDIFDSVLVSEGHGELVTMSRVLYPQGDDVVKRLGKPTKSAVYAPFSLRQIVEFIVLLPLNFIPVAGTPMFLVLTGYRAGPFHHWRYFQLLDLSKQQRKERIRRRQLQYTTEPRFGTVALILQLVPILSMFFLMSTAVGSALWTVDLENKRDLLGRRPGRDPEGLYHDDYNDDDAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PLZ1</accession>
    <name>A0A370PLZ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_335031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PLZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="369" mass="40124" checksum="1673815E41B476E4" modified="2018-11-07" version="1">MDGIDDLTALSDTMVYRHVLTVFSPVIPASLRRRITSLYPSTHRPVRLEASDSASVKENTAGEAGGDSMVSMRQSSESGGLEYVASMPDLSSGPTFQRPSTASSASNGLESCFSSVAEKSQELSDISSIRSSRSSDVFSPMAPKYEAESGLRWNRIAPALNLLQNACHEAQQRQCDSRLARMLYVDALGYLLDGLPDDMSSQETMTIRDNLPAGVKGSLAAPSVTDPSAAGLHSLLAEENSLPERSYLHRLLSSTIVYFFIMLQFLMPYVKILVCHLYQYERSHRITERAVTKVLVAADNFGKRGMVIGAAVLNYNEGRVSANLMDLAAWWVTSIAGGIYEGFAEGMTIMGVTRSHVELGKAFVQASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMC0</accession>
    <name>A0A370PMC0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_265231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMC0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56744" checksum="86DDC09CFDA57029" modified="2018-11-07" version="1">MAADAKSAPATEHKVKPTKPNEEAFKADLAQAEKEHAAVQAKLTEIKAKIETAKPNNQDSPAAKKQQELRAELSSIRQKQQGFKASRSSTQEKINALDATLKARISEQNNSRTRMSFKNVEELDREIARLEKQVDSGTLRLVDERKILSDVSNLRKQRKNFAGLEEAQKVINDLKTQIASLKKTLDNPEAKALSDKYSEIQKELDAIKAEQDSAFKNLNALRDERTKLHGEQQKKWTAIREIKDNYYKARKAYKEYEDEAWRVRREKQKAQRDAFEREKRKKIADKKLEEASRLAYTDEILTAQGLIRHFNPSYDFVSLGLDEKKDESSSFRADVGRTVDDSNLKGMKVLKKEDREEDYFVGTGGKKGKKGKKGANGSPAPGTPTETKFNLNVGVIEDFAKVKIDPPMNQSDVPAVIEKLAAKITEWKKNQASKTEENIKKAQEEIDRLEAEETAVNGATDAAKKPAIKNSGVNGEVSAEAELKQEKDAAADVSEELQKASLEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMC6</accession>
    <name>A0A370PMC6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_275588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMC6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK43348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="528" mass="59342" checksum="6F2DAE0EFBF8D0BD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMY2</accession>
    <name>A0A370PMY2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">M752DRAFT_158928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMY2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK43566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="205" mass="22283" checksum="9605D899ED2AF67C" modified="2018-11-07" version="1">MPSPFPPNATTKVCFVTVGATASFHLLLQSVLSDQCLLSLQKLGFTHLLLQYGKDGQALWDEFQSRCPPDSESRHGLEIAGFDFNQAGLDEEMGLTRADPSEGRVGGLIISHAGSGSILGALRLGVPLVVVPNPTLKDNHQEELARELQEQGYVVASNYWEISSALAHAEKLRAQMLAWPPVCGVSQRRQPTLESVMSDELGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PMZ1</accession>
    <name>A0A370PMZ1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_275722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PMZ1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000438">
        <property type="entry name" value="Probable thiol methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="31950" checksum="E15C199118898451" modified="2018-11-07" version="1">MTDQSTLTAAQQSVHNTLAKYPGEKYVDGWAEIWNANPSPPWDKGAPNPALEDTLMQRRGTIGNALATDAEGNRYRKKALVPGCGRGVDVLLLASFGYDAYGLEYSGAAVQACRQEEKESTTSAKYPVRDEEVGRGKVIFVQGDFFKDDWLEELGLGLNCFDLVYDYTFFCALSPSMRPDWALRHTQLLAPSPHGNLICLEYPRHKDPSLPGPPFGLSSEAYMEHLSHPGEQVSYDAQGRCRGDPLREPSDRGLERVAYWQPARTHEVGKDANGEVQDRVSIWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNC1</accession>
    <name>A0A370PNC1_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_326235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851851">
        <property type="protein sequence ID" value="RDK43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNC1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016605918" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="87412" checksum="E8AE95C939252683" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNC5</accession>
    <name>A0A370PNC5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_334590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNC5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK43696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="381" mass="40092" checksum="886CDADEAEC99EC7" modified="2018-11-07" version="1">MFKYTYRNRVASSARRYLSKQHSIPAAYYRGGTSRAVMFNQAHLPPRSEWDAIFRSVIGSPDPYGRQLDGLGGGISSLSKVCVVGKSTHPDADVDYTFVSLGVKNSDVDYSSNCGNMISAIGPFALDQKLVSSQTPESATVRIHNTNTGKIITASFPVVDGEAASSGNFAIDGVAGTAARIQLDFVNPAGSVTGKMLPTGQTRDEFDGVPATCIDVANPCVFVPASSLGVRGDLTPDDIAAHPDLLQRLDSIRRQAGVKMGIASTTGAVPGSIPKVCMVSPPQPSKGKDPVDLLVRAISVGQPHKAVPITVALAVSAAARVTGSTVEDATNQDRVSDAGLTIGHASGNLLVGAQFENDQLTAATVFRTARRLFEGQIYWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNX8</accession>
    <name>A0A370PNX8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M752DRAFT_275166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNX8"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="185"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDK43882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="501" mass="55365" checksum="D350A064770F1CBC" modified="2018-11-07" version="1">MAPPRPPYVCINCRLFGRRPFSSSTRRADIIRPATAPKPTPDIKHIRQNPELYSKNCVDRNYPAHAEYPLKIQQLTDEARRLDQDLKTPRARIKELEKAIAKVASAANNDSSSDLTSLRAEATRLKDDSNNMSTRKTTCTEEVHRLALSLPNLSSTHTPIGADPTLINYINFDPQSPPEWVTRPDPNRSHVTIGTKLGLLDFTSSAITTGWGWYFLTNEGALLEQALVQYALSVARRHGWKAVSPPSLVYSYIAEACGFQPRDQHNEQQIWTIEQTEKDKSKPQRSLAGTAEIPLAAMHAGRDIPASQLPLRLVGPSRCYRAEAGSRGVDTKGLYRVHEFTKVEMFAWADNLPDSTNTTSTSDDLFAELLSIQTEILTALNLPARVLEMPTSDLGASASRKRDIEVLFPSRLRAGDLESGWGEVTSASICTDYQSRRLGTRVRGGAAKESRFPHTVNGTAMAVPRVLAAILENGWDAERGVVVVPEVLRGFMGGLEVIGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PNZ5</accession>
    <name>A0A370PNZ5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_232188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK43907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PNZ5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK43907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="575" mass="64494" checksum="0A05AF78EE6B9709" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PPE3</accession>
    <name>A0A370PPE3_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_150104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851850">
        <property type="protein sequence ID" value="RDK44058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PPE3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="403" mass="43948" checksum="39B8B50EDC9771DF" modified="2018-11-07" version="1">MVSMVETSNSTQNDNPATEPVVPKTEPLPEGSISSAVSTPEAEGEILMQDVTQTQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIRQLESTIKRNEDSLQTLQQNHRSAADECLMLRYKNSLLERILLEKGIDVQAELRLKAGAPGAGAAKPTPMAAKPPSTLERAAVNRTSAQRHPGIAPKEPFGMAQHRDGAYGIPSPQFQATPPSHVSSPSHAKSPGFPFQGAMSPVGVDPQAQQRSQMLSHSRNISQTSPPMSIGQPESTDPKAAMPGGTNPRAPRVPSAYYPSPFQKHYDQLEQEYDAQADMIDEEHDSTVGASPYVSGYNNPASVPAGSHPMGAHNLNQYTQHAAEGANGAYNNANHLMGNYEPMLDADPFGLSASMHFQTPFSYEQNNTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQ84</accession>
    <name>A0A370PQ84_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M752DRAFT_334285</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQ84"/>
    <dbReference type="SMR" id="A0A370PQ84"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017077070" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDK44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="370" mass="38735" checksum="158C187F95078BB9" modified="2018-11-07" version="1">MPSAKPLFCLATLAGAALAAPAPSRVSDFTKRSTCTFTDAATASESKTSCSDIVLKDITVPAGETLNLKDLNDGTTVTFEGTTTWEYEEWDGPLLRISGKDITVTQSSDAVLDGNGAKWWDGEGTNGGKTKPKFFYAHDLDDSKISGLYIKNTPVQAISVESDNLVIEDVTIDNSDGDSEGGHNTDGFDISESTYITITGATVKNQDDCVAINSGENIYFSGGTCSGGHGLSIGSVGGRDDNTVKNVTFIDSTVSDSENGVRIKTVYDATGTVEDITYSNIQLSGISDYGIVIEQDYENGDPTGTPSNGVTISDVTLEDITGSVDSDAVEIYILCGDGSCSDWTMSGIDITGGETSSDCENVPSGASCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQH4</accession>
    <name>A0A370PQH4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_248500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQH4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="226" mass="24523" checksum="EB261B4449AEA102" modified="2018-11-07" version="1">MAIRPNVLSALRRFTSCDVGDALVKLGVSQGGYLSGLKMYSPDSMSPTAKFLGPAYTVKMVHASDKVSPTPKVHFADAIPKDSVVFVSQPKGLISACWGGLMSTRAQKRGAAGVIIDGKFRDINEHRELGMTLFARGISILGSNTFTRSSELDVPVTYENSENGGQVVINPGDYILGDADGVVVVPPEKAEECVQLCQERFEIDEETRRCLERGDEIGSTIKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PQJ9</accession>
    <name>A0A370PQJ9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M752DRAFT_248541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="KZ851849">
        <property type="protein sequence ID" value="RDK44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PQJ9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000006">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="452" mass="50136" checksum="C43F2BC7A93085C6" modified="2018-11-07" version="1">MVKITSFTTRDVRFPTSLDKTGSDAMNAAGDYSSAYCIIYTDSDYTGHGMTFTIGRGNEIVCSAISLLAPLVVGKDLDELTADWGKTWRYLVSDSQLRWIGPEKGVIHLALGAVVNALWDLWAKTLNKPVWRIVADMTPEEFVRCIDFRYITDAITPEEAIALLKEVEAGKQDRIKEAEQSQAVPAYTTSAGWLGYSEEKLKVLLKESVEQGYKHFKLKVGGNVEEDRRRLAIAREAIGYDKGNILMVDANQVWSVPEAITWMQQLAEFKPWFIEEPTSPDDILGHAAIKKALQDTPYGPIGVATGEMCQNRVVFKQLLQAGALTVLQADACRVGGVNEVLAILLLARKFGVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKKSVLEYVDHLHEHFVHPSSVKDGYYVTPMEPGYSVEMKAESMDAFSFPGEEGKSWWRSEEAKTILEGPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PRE5</accession>
    <name>A0A370PRE5_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M752DRAFT_274078</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PRE5"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDK44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="939" mass="100712" checksum="CB282782EF583E72" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSB5</accession>
    <name>A0A370PSB5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_131600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSB5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="95" mass="10647" checksum="8ADF5DA4D47E27A8" modified="2018-11-07" version="1">MCTVCTVPNLATGFSWSAEVIAITLAVDHRHFGAAMNLMRTKVRSILLWIPELGFISDKHAGSPRLSSDTAFQTQMWVRRSLLTDFGLSRRPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSM3</accession>
    <name>A0A370PSM3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_334027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSM3"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15197" checksum="38847EE6F1DF5798" modified="2018-11-07" version="1">MADAEPLYVYKLIPSTSPVREPLPDRLPVSELDEKSGFVHLSTAFQVPNTLKMFFKDEPLVYVLRIPFEGIAGQVRWENPEGTVCGPRPKEGLFPHLYNDLKLGKDEVETVAIWKNDEGWDKALLQAKPWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PSP2</accession>
    <name>A0A370PSP2_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_134298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PSP2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK45229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="152" mass="16907" checksum="194381F9E5325A36" modified="2018-11-07" version="1">MPQTQIPPQNPRKRRASPQSSSAATMAAPGAAPATGETAHEQGPGGSEPAPKKKGRTNTPWTAEEEQRLKTMRDAGRTWSEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESVALREAIREYDANKWKAIGLKVGKPAKACEQYAKEHFKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTF2</accession>
    <name>A0A370PTF2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_334066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851848">
        <property type="protein sequence ID" value="RDK45214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTF2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK45214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="25528" checksum="21F449FEF62D4866" modified="2018-11-07" version="1">MHPPSPQLLRALRTSISPNCSSSAICTQLASRSVSPLSRLTSSPLTFHRYNSNDARPTRMIPRAHSAKPSSRDRGPPSKEDTQTDFSALNVLGNIPAPTTAIDATLDTGFHLDNGVKITGGDGVFLVGGEAFVWRPWQGAEAGKNSMVNQKGQFEVPEHAWGILDLVWPRPDMLIIGMGETVFPLSPETKRHVNSLGVRVEVLDTRNAAAQFNLLATERGVSEIAAAMIPIGWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PTX0</accession>
    <name>A0A370PTX0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_311463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PTX0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="226" mass="26512" checksum="FD3152533C6457B5" modified="2018-11-07" version="1">MERTQTRRINEEVIRKFSTSEDEILADKVNIDLSMDSAYEWSIQVRKKLKKWHVQDLVNIKLPHPPKDDSTTWQNWKYLSGCVKIYILHNIPKGYIFDPRFTQQSTEYADILYETCLRIAVTPIAENLAIRYRGLMDFSQSAPHVLYKDDIELLARIVSSCNELDSTFISPLQATCILLSRLAKRNSEGKNYAEIVFARITPKDASNMTWDDFNELWKELLYWKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PU09</accession>
    <name>A0A370PU09_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_273835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851847">
        <property type="protein sequence ID" value="RDK45661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PU09"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK45661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="181" mass="20354" checksum="51DCBE066482ADC1" modified="2018-11-07" version="1">MPPQIAFISGPIDTGPNESYFHTHYPPLLTAAIARNDSFVLGPLPYGVDSDALSYLLQYPVSPARITIFVTSREDSLWGMQFRALGVNVHVVEGDSTHDRDVAMTAASTYDILRIRTEEEAKQMYGRLWREGYVTNTERNWRRRRGVGEDERVEAEVVNGVLGVNGGKKKKKRFLGKVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVL5</accession>
    <name>A0A370PVL5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_289750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVL5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="78" mass="8267" checksum="97D3254F81B23BBC" modified="2018-11-07" version="1">MSIPTLPGMRQSQKIPNLQRALAGSAPITAPTQTVHVLGNGPRGVEEGSSLRPVRMRVSGGQWALPAKVVSISYFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PVL7</accession>
    <name>A0A370PVL7_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">L-cystine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_99121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PVL7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000071">
        <property type="entry name" value="Lysosomal L-cystine transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32809" checksum="C8A5D09440C00FB6" modified="2018-11-07" version="1">MATQLEIFVRALSRLLGWIYTFCWSASFYPQPINNFRRRSTTGLAIDFPTINVLGFVCYTIYTSAFLYSPVIRHQYAARHPLAEDPTVRFNDFAFALHAVVLSFITYTQFWPFIWGFKVSRHQKVSKPVAGLFWGSIVGVTIVIFIVLGQSPNNGYDPYSWAWIDVIYALSYVKLVITIVKYVPQAWVNYKRKSTYGWSIGQILFDLSGGVLSLAQLLLDSSFQDDWSGVTGNPIKFLLSNVTIFFDLIFVVQHYILYRDAEDDSGKDRNPSDRTPLLSVSDGQPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW13</accession>
    <name>A0A370PW13_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_289885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PW13"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF5">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="513" mass="57687" checksum="2766EF733F5903DE" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PW90</accession>
    <name>A0A370PW90_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_324147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="870"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="870"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2261"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="902"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2440" mass="269247" checksum="95290DFEFFA2060D" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWK7</accession>
    <name>A0A370PWK7_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_324214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWK7"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="149" mass="16395" checksum="559EDE8054E4B42A" modified="2018-11-07" version="1">MSSFTQPVPVVACGRIPTMGKSISQHLLPEYQVIHFILSYEAAEAELPHLLAGRDPQSRSPNDIGTHDYSQPPRAVIFGRGYEPQQVEELKKKFAGVPKEPVAWVRGNPADLRAGAAGPEYAQNVAADMKKVLKKWRDGGGKDEEVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PWP4</accession>
    <name>A0A370PWP4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_290111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851846">
        <property type="protein sequence ID" value="RDK46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PWP4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="161" mass="18052" checksum="D584B2AA96862EA1" modified="2018-11-07" version="1">MSYTSSSRFSRSPSPAPRTRRPSPLERTSLHLRLSLLSGEKYDQESSAKEPDLRRCLSHAHIHAKSMAMVKRDIRVHIRSMGMAMDDDSDEELLDHEVLPPPPSRRSSRSSSKAAAAPRVTVSPKPSEKSSLLDKGRKCLEKLFPRKNNVHLAQSRVTVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PX80</accession>
    <name>A0A370PX80_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_288926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PX80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="323" mass="36091" checksum="AA788B704D0B4B6F" modified="2018-11-07" version="1">MFRIFNYPQPQPHLSTSPPTHHNPSPIPDIRVEIPSERLPGITYDDLPLLGARPSSSMLEYHQLPALRHLDWRIDDETGEPLRRPLKDVVSLTAAFAQTRGCEPLEPCVHCRVGKSVWKTCVVGFDTREGMGVHGACAACRFSRRGCSLNTQLEEPETPSRVKDEIESEGGAGAGPMTPPPSGSRRYLTAVPVAAAGRGRGRGGIRRRGSRFTRQRPYNLRPRIATPTPSRSDMGYNSHLERGSERRIKSEKSDLLTSSPGTSRLDGSILPFPLGPETIDDLPFLRQAVTEMEMHLGILRRRVRQLEDRERVKNNSIDPWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXM2</accession>
    <name>A0A370PXM2_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M752DRAFT_244990</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PXM2"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="301"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDK46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="482" mass="54930" checksum="CDC90D8A17CE12D3" modified="2018-11-07" version="1">MRSILGRVPRVGHVLPQVPRARWNTCSIAPAILGAATTRGGYNGSAHMQPNRGAVWMPLDRRWFRAGIPGGSGMRNTRTKEQLERLRLRDRTGGVQEEQKGGDSGGKLEDAMTKGKLLTTPSRLFKLLIPLSTGYQGEHKDIEPIAILVHPQQPLSHLERLIQSEVPAIKKEDGQTRPPTVSFIALQIEDHPIRPRKAVYEGTGAEVHQLDEMGRIDDGEGKRTPTEDDTYTYLRRTEPTKKGEESEGGGRREQRFVRWSQSTEIGDFIRDAARAREFIVSVEGAPAGVHQIRVAVPSFDERTYFLRMRLRKISGRIKGIAEIKHECDALAHRGAQRVAMGGLGILAMWWYLVYRLTFETDLGWDTMEPVTYLVSLSTLMGGYLWFLYHNREISYRSALDFTINARQKKLYQEKGIDLQLWESLIDEGNTLRKEIKNIAAEYDVEWDERKDERDQRVTEALKQERTQKNGNKRRGDEEEDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PXT8</accession>
    <name>A0A370PXT8_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_272785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
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</entry>
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        </source>
    </evidence>
    <sequence length="511" mass="57262" checksum="3D3A5C15342473F8" modified="2018-11-07" version="1">MIDEEKTQEVVHGLKTTPDGLILDPQPSDDPNDPLVCSASGLSGQKLTKPELEAFEKGAYTFDMGNRLLLESSYLYDEHAGIISSGASLSQDGYSDFPLLVPLSRRYGSCICLFWSTIGILFGAVWSAMMTSSSDYIPFLISRLFSGLCAGVPLILGSEFVMRAFFRHQRGKCLHILHIPFLMGVSIGPTLGAYIDARASWTVSFWYTVPLNGVLALVILIFLEEAVYAEGEQKRQSFLQEKWNMYVRGRAIPPQLRASWKNMTLALRQWLLSSVSTSLKPLETMVDTQCQRFRWPHVCAQYSLLFTLAVNLNTTVTLTQAIGTALAELYGHFISDRLPLYLSHRKSKTQVIEPAEWRPEYRLHCLWIPVIMLPVGLGLFGASLEYHYHWVLLALGFLLLTFGAISLLPVAMTYLCDCFPNYVSEVSAGMGVWRLILGLLSTVFITPWNDRVGPGWLFGSAGLITLPAFGGVMFLMVFGRQVRQMGFQKRLRTASQNRTILHNQVTTYSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY64</accession>
    <name>A0A370PY64_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_70325</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PY64"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="281"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="869"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK47131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="899" mass="97280" checksum="35597F29611E8CFD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PY88</accession>
    <name>A0A370PY88_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Peroxidase</fullName>
            <ecNumber evidence="22">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">M752DRAFT_245292</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="22"/>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47125.1"/>
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    <sequence length="555" mass="61509" checksum="D6431A9D74D70053" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYL7</accession>
    <name>A0A370PYL7_ASPPH</name>
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        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">M752DRAFT_317127</name>
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        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">ATCC 13157</strain>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDK47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="698" mass="77069" checksum="1F3582D948BECFCD" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PYY4</accession>
    <name>A0A370PYY4_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_271718</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PYY4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827521" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="257" mass="23300" checksum="571E806031CB5501" modified="2018-11-07" version="1">MKTFSLSLALLAAASMVSADVSVSDCAQMCLSNMSAKASELGCSSGDLSCLCSKPDYSYGIRDCTAQACPNDDANAVVSSALASCPTSSGSSDSASATGASSTGSGASGAGSTTSASSASSASGSGASSASGTNSGNTSGATTGATTSGATSGATTLSTITSTSTSTGTVSGQTTLSTITGTSTSTGTVSGATSGSSGSSTSGSGSGSGSGSSGSGGSSSATGTAPSSSETTGAAPKLNVASSGIAGALGLAAMFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZA1</accession>
    <name>A0A370PZA1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_322588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZA1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF8">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK47523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="523" mass="59060" checksum="1148243C50C716F0" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZB9</accession>
    <name>A0A370PZB9_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M752DRAFT_272973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851845">
        <property type="protein sequence ID" value="RDK47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZB9"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDK47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="114" mass="12628" checksum="D8A15F4DE0423B34" modified="2018-11-07" version="1">MLSFRSVFGASTGALRQILPSFSRRSAALVSRPFSQIARLSLGNGLRLLRSGKQTNNVGVASVGSTLRQVEQVRGMKTRSSVKRLCDGCKPVRRKNRVYIICSKNPKHKQRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZX5</accession>
    <name>A0A370PZX5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_4724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZX5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK47740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="245" mass="27798" checksum="5AA2A53B02F8FF67" modified="2018-11-07" version="1">MPTFWPSITPELRDWALRQSVFFVASAPLQGKHVNVSPKGFPDSSFAILGPNEAAYVDATGSGSETISHVRENGRLTIMFCSFDASPGIVRFFCTGSVMEYDEPEFSDYLERMGGKKVVGARAIIRLNVFKVQRSCGYGVPRLSLQVDSETNNTKPYLQDRDTLGHWTGKRVEANELRTYQKEWNVRSLDGLPGLHRALKDNHQLVWVKRLGNWTRRHRDEIEMVKTSILLLFVSMAILQWAGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PZX6</accession>
    <name>A0A370PZX6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_322736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PZX6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016828631" description="Arylsulfotransferase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76529" checksum="A4B2420DFE00EB10" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q003</accession>
    <name>A0A370Q003_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair protein rhp54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_331331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q003"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="237"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="570"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="813" mass="91333" checksum="788DE45EEEAD6CB8" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q0P0</accession>
    <name>A0A370Q0P0_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_8960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q0P0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="111" mass="13108" checksum="063E8164C4AC73FE" modified="2018-11-07" version="1">MSNKFRSLQRKKNARSLVSEDPWKVDTPFGPPRIPHFPGRGMRRLRSTLQKLSPSARAERELLRQKNRYKIPLTERNVDALVTEQLFTDACYPDKHSRELQISAWLERLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370Q1J0</accession>
    <name>A0A370Q1J0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M752DRAFT_244583</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KZ851844">
        <property type="protein sequence ID" value="RDK48317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370Q1J0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="432"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="570"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDK48317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="659" mass="73199" checksum="56483DB5CBEA1A14" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3P5</accession>
    <name>A0A370P3P5_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_226420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851885">
        <property type="protein sequence ID" value="RDK36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3P5"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016886178" evidence="2">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="239" mass="26368" checksum="DC841AE292D9B872" modified="2018-11-07" version="1">MGFLGLFFTAGALLLMFLTLLGGARNSRPLNEIFFLQVDTSNIPGAPSLSRWTFWEICAVTANGKNLCGSSYPDFPFDPPSHRNFDTTQNIPSAFIGTNHYFLTSRFSFPFLIIALFFGVVSLFTGFLAMCTRIGSYVSSLMAWIALVFQIITTCLITAVYVQGRNKFNANGQSASVGVKAFAFMWTAVACLMLACMFYCMGGAVGRKERGYSGREHRRRGFFSSARSNSVRSNKETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3U6</accession>
    <name>A0A370P3U6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M752DRAFT_322392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KZ851880">
        <property type="protein sequence ID" value="RDK36524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3U6"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="371"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="543"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDK36524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="694" mass="77334" checksum="192764C38DAAA049" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P3Z0</accession>
    <name>A0A370P3Z0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_311145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P3Z0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="348" mass="39764" checksum="3A79729A46CB7C53" modified="2018-11-07" version="1">MWPDDIGSQVGSQLSRPVTYVITSFLSIALYNVVELTFILLLTFKRRKGLYFWSFVVATWGIAIYSIGFILKDFNLVDNAISYFYVTLIVTGWCAMVTGQSMVLYSRLHLVVRHHIMLRFILGMILCDVFLLQVPTIILCYGANSSTSDRFVLPYAIYERIQVTVFFIQEAIISGVYVYETFRLLRSEDEILEGTHREAARRLMLHLILMNIIVILLDIAILVLEWAGRYASQTAVKGFIYSVKLKLEFDILNQLVTFVYHSHISNSANLEGESSSRNFWDINQQAEQNNAPARHTHPRHCAWADAANRIRRDFTISAEKKMIKIIQSARKQSSSSGSPQDADSDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P411</accession>
    <name>A0A370P411_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_260224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P411"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="298" mass="33538" checksum="C48624A00E737034" modified="2018-11-07" version="1">MDDFPGDALRWFGEEHDLDLALDKDITHTVNSPMKMPHRKLKRPCIRRTLSLNSATFIRQPSFTASHKNHRHSSQSPVTSSFLTNLLIRESKSRPLSSQAQGHHASQSSFCSIDPGAQHYQDPEARLKLRLYLASPHNFDEAIEFGFPTPADGTTSVRPSLPKQSLKPQNKRRKLYTAVAQNADLCTETDGTISDAVQPSQLLGPPISNKSISLSDTQQFCAVDRGSGKRLDPNNREMTLKMTLTRPDLRTSYWEDVPSGTPMSIESHSAEGNPHICNADENIRHKMRTVWCKLRVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P417</accession>
    <name>A0A370P417_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_280287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P417"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="142" mass="15215" checksum="037F46C2411B0A01" modified="2018-11-07" version="1">MVHAADHLSAQELETLSTKAIAAKDTAYCPYSKFRVGACILTESGEFVQGANVENASYPVGTCAERVAFGSAIVAGHRNFKAIAVATDIKPPASPCGMCRQFMSEFTTPEFPIFMYDGEGNYTLTTMGELLPSSFGPSDFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P428</accession>
    <name>A0A370P428_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_280326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P428"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK36547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="565" mass="60778" checksum="1AC2CB31AC430A79" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P442</accession>
    <name>A0A370P442_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M752DRAFT_299091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851879">
        <property type="protein sequence ID" value="RDK36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P442"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDK36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="756" mass="84448" checksum="AC781954556C3296" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P489</accession>
    <name>A0A370P489_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_340323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KZ851878">
        <property type="protein sequence ID" value="RDK36607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P489"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK36607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="362" mass="40956" checksum="9492DCAFB0ADD24B" modified="2018-11-07" version="1">MVTQRDRELFREDIRSRGTKLNAAERENLLRPYLPDPSDLPRKPPQRRKKVPRKTPIRTFIKSQLHLLTYTVVHIIFGIFSRLILSYYAVVDRIFAIVYYHHRTPELIRKDVKGLKRLPEHLSVILSLRKEDDALAILMDEVAELSAWSVSSGIPVLSVYEKTGVLKSCIPVLHQAITSKLSSYYGSPAQQPTLQLFAPHHPIYNTQQDVPPSDRHNASSLTLLLLSATDGRETFVDLTKTLAEMSQSGKLSPEDITMELVDAEISEITTQPTQPTAPVNQGSTRMGLSRQVSLVKPEPDLLLVFGSFLKLDGYPPWHIRLTEMYCTGGRNSGITNSDEAVEYHGFLRGLWHYAGAQMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P4G8</accession>
    <name>A0A370P4G8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_280215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851877">
        <property type="protein sequence ID" value="RDK36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P4G8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="173" mass="18944" checksum="7AF8763C9ED43681" modified="2018-11-07" version="1">MDVSNNRLFRWSKPEWLNNSAVRNAGVYTSGALFSLGFFFLIDAAAFSHSARNGSFVHVKFVDWIPGICSALGMLVINSIEKSRLHADSFSYSGSGVAWKARFVLFLGFALLAGGLAGSVTVMVLKYLVQGYPLPTLYFGIANVIANGLVMLSTIVLWISQNIEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P500</accession>
    <name>A0A370P500_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_225424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851875">
        <property type="protein sequence ID" value="RDK36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P500"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="496" mass="55518" checksum="B609428991362713" modified="2018-11-07" version="1">MIKTVSPKCLNCPTFRAGKCAGTAKRLVATDTSPITRKDKKEGDISSVFTSFSGRKSAPLPERFRDLKRNLTTGFEDQIQKSWDELVEVLKVRTEEVATKRENIIPQLNFSDIRAGNVSPADIAAIRRTGVAVVRGVVEKDVTEKLLSDVRQYLTSRPFKGFPSTSDKKVIYESYWSPSQVKARSHPNMLATQSWMNQLYTADANQKINLSVPLSYCDRVQIRPPGDKLFGLPPHVDGGGVERWEDRAYNHTYRKIFQGKWQEYNPWDLTGRLDANMNMYDAPGGCSVFHTFQSWLGLSRHGPQQGTLVVHPILQPTTAYWMLRPFFKPTRKDSLDGWKFSLDDDEGDVFLHGANPGTAQEHTPTLHPHLRLSETMIPYPTVEPGDTVFWSADTIHGTEMENTGDIDACVFYIPSVPLTPNNMQYVKQQREAFLKGVPPPDFPGGLGESQFSDRATIADIQSEAGKVAMGLSAIKLDGKDENSKKLGQEMNAMLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P570</accession>
    <name>A0A370P570_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M752DRAFT_339996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P570"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDK36994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="109" mass="12261" checksum="F6EB74C609DA028B" modified="2018-11-07" version="1">MKISLPLLETGKLDPSLEDQDGFTPLTYATEYGNKRIIKLFLDASDPRAAKTATTELEMFAATRATPELQPVNERTVVEAKPSELVSRTSPRDVVRLRWRKNPALNPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P582</accession>
    <name>A0A370P582_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_280000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P582"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="372" mass="41197" checksum="A601246F4A07DB1A" modified="2018-11-07" version="1">MSKRISTFFQPLPSKKLKPDATTTAQSSSSSTTTVPPKPSTYTHHPSYPIPIRDPPSTIATPLLSNPAPRPPKALTDHPHLDLLYFQPFLPSPLARDLFQFLRNELPFYRVRYTIRRGGTETSINTPRYTTVFGVDDTSTFVIENSESTSSNSETSVRDDTTNNLLDPPPANSPILVDSKTRTPLTESKSKSKYRCRPRPIPPCLDILRQAVEKATDDGTRYNFVLVNYYATGDDSISYHSDDERFLGQNPTIASLSLGAGRDFLLKHKPGAAGGTTDTDRAIANAAAKPLKFPLKSGDMLIMRGETQSNWLHSVPKRKGLQGSAGALGRINITFRRAVVPGGTENYYRYNVGDGEVYRWRDEEGKMVATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5I3</accession>
    <name>A0A370P5I3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M752DRAFT_259421</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="KZ851874">
        <property type="protein sequence ID" value="RDK36987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5I3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000823">
        <property type="entry name" value="Cell cycle control protein (Cwf8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDK36987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="476" mass="49823" checksum="7706E9512A9F1090" modified="2018-11-07" version="1">MLCAISGEAPQVPVVSPKSGSVFEKRLIEAYIAENGKDPVNGEELSTDDLIDVKSQRVVRPRPPTLTSIPSLLSVFQEEWDALALETYTLRQTLAQTRQELSSALYQHDAAVRVIARLTKERDEARDALSKVTVGARSAAASGGEAMQVDSTGLPEAVLARVESTQASLSKTRRKRPVPEGWATGDAISTFKPTESSNPLYPGSKAFAVNSSGELALIGGADGAVGIYSIPQKQVVQNLQANGPVTDAAWAGEKAIVASSTGSVKVFENGNEVANFNSHAGAATALAVHATGDIVASVGADKSYVLYDLTTNSVITQIFSDASLLSVKIHPDGHLVAAGGVDGQIKIFDIKTGASAATFTMSGPVKSLFFSENGVFLAAVTENSTTVSIWDLRSAQESKVLETGSQVDSINWDYTGQFLLTAGPSGLTVHQYTKASKSWSEPLRSAVPAVAAAWGSAAQAIVALNSEGGVTELTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5Q0</accession>
    <name>A0A370P5Q0_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_241784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5Q0"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="597" mass="64602" checksum="B594D2D5CDA4CE56" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P5R4</accession>
    <name>A0A370P5R4_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_106208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851873">
        <property type="protein sequence ID" value="RDK37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P5R4"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="145" mass="16103" checksum="2AB8BF1116ED81A5" modified="2018-11-07" version="1">MSPSTRRLLKESADLQTNPSPYFHAAPVSESNLFDWHFTLLGPPPPSPYAGGIYHGRITLPPTYPLRPPSFRFLTPSGRFEVNREICLSISGHHEETWQPAWGIRTALIALRSFMDGDAKGQVGGLDVGEEVRRAYARRGEGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P622</accession>
    <name>A0A370P622_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_259117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851872">
        <property type="protein sequence ID" value="RDK37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P622"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="478" mass="53673" checksum="C2018701A24298CF" modified="2018-11-07" version="1">MPDLRRQVLESGKTISRKAASREGSRRTSRANSTQNSRHSSQNQSRHASDEEDLDSLSDDTAMSIGSLDDLTDNPDLDNHDWVEELGDVIEDILDRKRSSNLSREEAYAAFCRLAKYHYVEEQIRGRVLDLVAAFNRSIKFETSVRETTLALRAVELLAISAYDNTIYEHVEPLLTRTVRDSTSNTVKAAAIHCLGVCTIHAGASEDGILDQMTFFLDIAASDGQSIGAGDDAASVVAALQEWGVLATYIDDLEGESEDAVQIFMDQLNSGDSAVQIAAGENIALLYEKSYTPQEDDEDDEDEEEESEEETFLSGGRGNGPKLIKRYNAYHNTHELEQQLHSLAKVHSKRISKRDKKSLHSNFASILTTVENPRRGPMYNTAIDQDTNRHYGSKLTVKIGRQGVMNIDRWWKWTRLSSLRRTLQGGFAAHYYQGNRAVLESLPVIMRMDTPSDRGYAKRTAKHRDSRRWAVHEASDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P659</accession>
    <name>A0A370P659_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_339641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851871">
        <property type="protein sequence ID" value="RDK37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P659"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27697" checksum="B1FFC0AF2F9918A2" modified="2018-11-07" version="1">MSQASTVVSEMTTHPSSPFHLRPAKPTPTDHAFILSAFDSSLPLLASIGSHEQWGSTPFSQRGDFPQETLKELDQSEEYRLTGKSNMDGLRIFIVERKYHHDDKEHTGSLSSHLRVTSDGQCFLPVGFAYVRENWIPNYVKSQHHLPMPIIHSSTEIGGFLYLEVMVTDTRVGRLCRGAGSALIRGMREYGQGRGMKALWVDGWAGNERKLIRYYEQQGFRAVGDWSHTRANNVPWLGTLMCMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P6T6</accession>
    <name>A0A370P6T6_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase M</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M752DRAFT_90327</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ851870">
        <property type="protein sequence ID" value="RDK37588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P6T6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579711" description="Probable beta-glucosidase M" evidence="19">
        <location>
            <begin position="20"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="688"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDK37588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="765" mass="82130" checksum="4F8940B05D6FDE68" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7N6</accession>
    <name>A0A370P7N6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">A1pp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_321679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ851869">
        <property type="protein sequence ID" value="RDK37717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7N6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF121">
        <property type="entry name" value="ADP-RIBOSE 1''-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Macro" evidence="6">
        <location>
            <begin position="93"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK37717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="600" mass="66368" checksum="86DBD32FCE48A4E4" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P7P6</accession>
    <name>A0A370P7P6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M752DRAFT_329925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851866">
        <property type="protein sequence ID" value="RDK38195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P7P6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF7">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDK38195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="422" mass="45515" checksum="9DC63055E0951B59" modified="2018-11-07" version="1">MTVTDLVNHPAQGISYFTPAQNTPAGTAANPQSSGKPVPKLFHPLTVRGVTFQNRLGLAPLCQYSAQDGHMTPYHIAHLGGIAQRGPGLMMIEATAVQPEGRITPQDVGLWKDSQIGPMRQVVEFAHSQNQKIGVQLAHAGRKASTVAPWISATAMATEELGGWPDRVIGPSDIPFADTFPKPKAMTKDDIVQFKNDWAAAVKRALEVGVDFIEIHGAHGYLISSFLSPAANNRADEYGGSFENRIRLPLEIAQITRDIVGPNVPVFLRVSASDWLEETLPEQSWGTEDTVKFAKALADQGAIDLIDISTGGVHAAQKVKSGPLFQAPFAVAVKQAVGDKLLVSAVGAITNGRQANDLLEKEGLDVALVGRGFQKDPGLTWTFAQHLDTEISMASQIRWGFTRRGGREFIDPSVYKPSIFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P821</accession>
    <name>A0A370P821_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_222120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P821"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="491" mass="55489" checksum="311945BC501B2833" modified="2018-11-07" version="1">METPEDSNKGPIDRFSSVNEHLSVEIRPEDERALVWRLDCFFLVVGFLGYAFKYLDQTNISNAYVSGMETDLELYGNEYNYFTTFFNIGYMIMLYPSCIIISHIGPSIWLPACEVLWGILTCCLSTVTSAKQVYGLRFLIGFFEGATWPGYFTIISQWYLPHEMALRMSLYNMAQPVGAMLSGAMQGAMSTNLEGVMGRSGWRWAFIINGVCTIFIALLAFIILPGFPERQNPLSKIYLRPQHIKTAIARTRRVGRKPQIGIQVKSFLRCFRFWHLWLFAIAWAIGTGTTPTSYFNLWLKSLKNPDGTAKYSVAMLDYLPIAGQAIQLVAEILFSGFSDYFGVRLPFLLLHAVINIVSLIILTIQPSNEHAYMAGWYMDYVGAVSTMLLCAWASAHLETEPQVRTVLFATGTLFSYLLSAFLPIAAYPASEAPHWRIGAKLYLGLSCLAAVLFVCIHFAFKWEEQKKAKTRRVEDWNVTADEDRVSEGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P822</accession>
    <name>A0A370P822_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M752DRAFT_278970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P822"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDK38332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="661" mass="73413" checksum="076804327DDA0EF1" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P832</accession>
    <name>A0A370P832_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M752DRAFT_338926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P832"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDK38340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="234" mass="26574" checksum="2B87E554573656ED" modified="2018-11-07" version="1">MEVLYTKPQSSPYFFGGPQPWSSFSWASSDDRVRGGSSHSYLTINEDTNTATFHGNLDIKTLGGAGFASQHTASTTELWDLSSYAGLELSIPKSDGHTYTLNLRDELQDPRPDGRQRSGLVWEAKFKVEKGQTKVRLGWKEFRPTYRGREVHMGRPLILAGVKRFEIMIRSFFGEQEGDFELEIESIKGIEQEKGRYRDDPNDSGDDDKYYDEKQQPYSEDEDTGLGWLCCGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8D3</accession>
    <name>A0A370P8D3_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_78945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ851865">
        <property type="protein sequence ID" value="RDK38445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8D3"/>
    <dbReference type="ESTHER" id="aspna-g3y5a6">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="152"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="511"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDK38445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="800" mass="89043" checksum="25AC5FBFBEBFC706" modified="2018-11-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P8Z6</accession>
    <name>A0A370P8Z6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M752DRAFT_278902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ851864">
        <property type="protein sequence ID" value="RDK38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P8Z6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016664011" evidence="5">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="36"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDK38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="412" mass="45511" checksum="D46EE79B8FAAC417" modified="2018-11-07" version="1">MHLGNSLSLLCLAAPGLVASISSSPLSTSGRWIVDTDGNNVTYAGVNWPGAEVAMLPEGLQYQSIEYIVGKIKDLGMNVIRLTFAIEMIDDIYETGADVPIKTSLTNALGETNGTKIYDDVVSNNPQFGENTTRLEVYDAVANECYSQGIYVHLDNHVSKASWCCSTTDGNAWFGDTYFNVSNWHRGWKYMAEHVKSLPAVKSIGMRNELRSPDDNTTLADDTYNWETWYSNMVENANQVHSVNSDLLLFFSGLNYDVTLSPIPTASDLGDGTVFKKSDFDFADKIVLELHNYDSSATSCSSLSSSLLSDGFDALETNDSSIVNVLPVVMTEFGYAQDDTTYTEVYASCLREWLPSVHAGWMIWVLSGSYYVREGIQDYDETWGLLDHTWSGWRSTEAIDNGIIPMVNASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9N1</accession>
    <name>A0A370P9N1_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_278744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9N1"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="114" mass="12462" checksum="634467CA3024AAA1" modified="2018-11-07" version="1">MNACKRMLPGLRSVATKSVFVPARSFSVSSPFMREAAPTLPTKKPVGAFRGGLFGFLTGAIAASAGVYFYILGEYRIANEMLTEDIIALQGATQKLQTYIGELERKVDQLQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9S6</accession>
    <name>A0A370P9S6_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M752DRAFT_269531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 13157</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ851863">
        <property type="protein sequence ID" value="RDK38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9S6"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDK38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="236" mass="27181" checksum="7A004192FE375701" modified="2018-11-07" version="1">MPVIPTETFGVANELGVQGRFVQNALHPWGVNRRKGNKKKKHGRDESEDEVNPKGGKRGTLIPDIVLVESQRHTIWALCEVKTHWGFQPGKNETWKTFMSQKMGQLARYMDDNYCRYGIYTVYEYTWFLKRVDDTHFAVSQAISASTISTSSIGSLRECLLAMVIRAAHEEWSYYPVRYGKRLYVPALTSQLHRKHEMIERMTFIQSSNALFGPRQNGNNKGYILSRTLEHQAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370P9Z8</accession>
    <name>A0A370P9Z8_ASPPH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M752DRAFT_296562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370P9Z8"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDK39002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000254937"/>
        </source>
    </evidence>
    <sequence length="286" mass="31821" checksum="B8046148EAA11574" modified="2018-11-07" version="1">MSSSYELYRYTPSLGAAILFLVLFIFITAYHAYQMAQARAWYFTCFVLGGIFQIIGYITRALAHSNTQSVTIYAIQDILILLAPPLYAATIYMTLGRLITFLDAERQSLIPIRWLTTIFVTGDVLSFLLQGAGGGIMASGTLSGMTTGENVVMGGLAVQLIFFSVFVIVATLFHFRIHQNPTEKSLSTCIARSGWRNPNWETTIVGLYIASMLILIRSVFRMIEYAGGNDGYLMSHEAFSYVFDAVLMFFAMVVISVLHPSKVLGSGKAGEMNKRESVQLQRLYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A370PA80</accession>
    <name>A0A370PA80_ASPPH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M752DRAFT_256123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus phoenicis ATCC 13157</name>
        <dbReference type="NCBI Taxonomy" id="1353007"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-07" db="EMBL/GenBank/DDBJ databases">
            <title>Section-level genome sequencing of Aspergillus section Nigri to investigate inter- and intra-species variation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Frisvad J.C."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Hoof J.B."/>
                <person name="Brandl J."/>
                <person name="Salamov A."/>
                <person name="Riley R."/>
                <person name="Gladden J.M."/>
                <person name="Phatale P."/>
                <person name="Nielsen M.T."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Strasser K."/>
                <person name="McDonnell E."/>
                <person name="Barry K."/>
                <person name="Clum A."/>
                <person name="Chen C."/>
                <person name="Nolan M."/>
                <person name="Sandor L."/>
                <person name="Kuo A."/>
                <person name="Lipzen A."/>
                <person name="Hainaut M."/>
                <person name="Drula E."/>
                <person name="Tsang A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="Simmons B.A."/>
                <person name="Makela M.R."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 13157</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ851862">
        <property type="protein sequence ID" value="RDK39076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A370PA80"/>
    <dbReference type="Proteomes" id="UP000254937">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
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